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https://www.readbyqxmd.com/read/29330023/unraveling-the-differential-structural-stability-and-dynamics-features-of-t7-endolysin-partially-folded-conformations
#1
Meenakshi Sharma, Dinesh Kumar, Krishna Mohan Poluri
BACKGROUND: Characterization of partially collapsed protein conformations at atomic level is a daunting task due to their inherent flexibility and conformational heterogeneity. T7 bacteriophage endolysin (T7L) is a single-domain amidase that facilitates the lysis of Gram-negative bacteria. T7L exhibits a pH-dependent structural transition from native state to partially folded (PF) conformation. In the pH range 5-3, T7L PF states display differential ANS binding characteristics. METHODS: CD, fluorescence, NMR spectroscopy and lysis assays were used to investigate the structure-stability- dynamics relationships of T7L PF conformations...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29305015/alternative-splicing-in-genetic-diseases-improved-diagnosis-and-novel-treatment-options
#2
Atze J Bergsma, Erik van der Wal, Mike Broeders, Ans T van der Ploeg, W W M Pim Pijnappel
Alternative splicing is an important mechanism to regulate gene expression and to expand the repertoire of gene products in order to accommodate an increase in complexity of multicellular organisms. It needs to be precisely regulated, which is achieved via RNA structure, splicing factors, transcriptional regulation, and chromatin. Changes in any of these factors can lead to disease. These may include the core spliceosome, splicing enhancer/repressor sequences and their interacting proteins, the speed of transcription by RNA polymerase II, and histone modifications...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29303373/cardiac-autonomic-function-and-reactivity-tests-in-physically-active-subjects-with-moderately-severe-copd
#3
Jibril Mohammed, Eric Derom, Tine De Backer, Inge De Wandele, Patrick Calders
Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated...
January 5, 2018: COPD
https://www.readbyqxmd.com/read/29298773/the-phenomenon-of-albumin-mediated-hepatic-uptake-of-organic-anion-transport-polypeptide-substrates-prediction-of-the-in-vivo-uptake-clearance-from-the-in-vitro-uptake-by-isolated-hepatocytes-using-a-facilitated-dissociation-model
#4
Seiji Miyauchi, Masayuki Masuda, Soo-Jin Kim, Yuudai Tanaka, Kyeong Ryoon Lee, Shouko Iwakado, Momoko Nemoto, Shotaro Sasaki, Kazumi Shimono, Yoshio Tanaka, Yuichi Sugiyama
The effects of bovine serum albumin (BSA) and human serum albumin (HSA) on the unbound hepatic uptake clearance (PSu,inf) of the organic anion transporting polypeptide (Oatp/OATP) substrates 1-anilino-8-naphthalene sulfonate (ANS) and pitavastatin (PTV) were determined using primary cultured hepatocytes of rat and isolated hepatocytes of human, respectively. The PSu,inf value of hepatocytes was estimated by dividing the initial uptake rate of these anions by their unbound concentrations. The PSu,inf values for ANS and PTV were enhanced in the presence of albumin, thereby demonstrating the phenomenon of "albumin-mediated" hepatic uptake...
January 3, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29297327/the-factors-affecting-the-evolution-of-the-anthocyanin-biosynthesis-pathway-genes-in-monocot-and-dicot-plant-species
#5
Olesya Yu Shoeva, Anastasiya Yu Glagoleva, Elena K Khlestkina
BACKGROUND: The available data demonstrate that even in universal metabolic pathways, some species-specific regulatory features of structural genes are present. For instance, in the anthocyanin biosynthesis pathway (ABP), genes may be regulated by ABP-specific regulatory factors, and their expression levels may be strongly associated with anthocyanin pigmentation, or they may be expressed independently of pigmentation. A dataset of orthologous ABP genes (Chs, Chi, F3h, F3'h, Dfr, Ans) from monocot and dicot plant species that have distinct gene regulation patterns and different types of pollination was constructed to test whether these factors affect the evolution of the genes...
December 28, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29291263/overexpression-of-anthocyanidin-synthase-ans-gene-in-strawberry-enhances-antioxidant-capacity-and-cytotoxic-effects-on-human-hepatic-cancer-cells
#6
Francesca Giampieri, Massimiliano Gasparrini, Tamara Yuliett Forbes-Hernandez, Luca Mazzoni, Franco Capocasa, Silvia Sabbadini, José M Alvarez-Suarez, Sadia Afrin, Carlo Rosati, Tiziana Pandolfini, Barbara Molesini, José F Sanchez-Villa, Iraida Amaya, Bruno Mezzetti, Maurizio Battino
Food fortification through the increase and/or modulation of bioactive compounds has become a major goal for preventing several diseases, including cancer. Here, strawberry lines of cv. Calypso transformed with a construct containing an anthocyanidin synthase (ANS) gene were produced to study the effects on anthocyanin biosynthesis, metabolism and transcriptome. Three strawberry ANS transgenic lines (ANS L5, ANS L15 and ANS L18) were analysed for phytochemical composition and total antioxidant capacity (TAC), and their fruit extracts assessed for cytotoxic effects on hepatocellular carcinoma...
January 1, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29274832/extremely-preterm-fetal-sheep-lung-responses-to-antenatal-steroids-and-inflammation
#7
Kevin Visconti, Paranthaman Senthamaraikannan, Matthew W Kemp, Masatoshi Saito, Boris W Kramer, John P Newnham, Alan H Jobe, Suhas G Kallapur
BACKGROUND: The efficacy of antenatal steroids for fetal lung maturation in the peri-viable period is not fully understood. OBJECTIVE(S): To determine the lung maturational effects of ANS and inflammation in early gestation sheep fetuses, similar to the peri-viable period in humans. STUDY DESIGN: Date-mated ewes with singleton fetuses were randomly assigned to one of 4 treatment groups (n=8/group): 1) maternal intramuscular injection (IM) of betamethasone (Beta), 2) intra-amniotic lipopolysaccharide (IA) (LPS), 3) Beta+LPS, 4) IA+IM Saline (controls)...
December 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29251663/pain-or-nociception-subjective-experience-mediates-the-effects-of-acute-noxious-heat-on-autonomic-responses
#8
Dominik Mischkowski, Esther E Palacios-Barrios, Lauren Banker, Troy C Dildine, Lauren Y Atlas
Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent one or two pain assessment tasks...
December 13, 2017: Pain
https://www.readbyqxmd.com/read/29250718/vertical-skeletal-changes-after-extraction-and-non-extraction-treatment-in-matched-class-i-patients-identified-by-a-discriminant-analysis-cephalometric-appraisal-and-procrustes-superimposition
#9
Philipp Beit, Dimitrios Konstantonis, Alexandros Papagiannis, Theodore Eliades
BACKGROUND: In the long-lasting debate of extraction versus non-extraction treatment, the impact of extractions on the skeletal vertical dimension remains rather unclear. The aim of this retrospective research study was to obtain a bias-free sample of morphologically similar borderline patients treated with or without extraction of the four first premolars and to retrospectively evaluate the vertical changes that occurred. METHODS: A borderline sample of 83 patients, 41 treated with four first premolar extractions and 42 treated without, was obtained by means of discriminant analysis applied to a previously investigated parent sample of 542 class I patients...
December 18, 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/29247728/glycine-rich-loop-encompassing-active-site-at-interface-of-hexameric-m-tuberculosis-eis-protein-contributes-to-its-structural-stability-and-activity
#10
Shashi Anand, Charu Sharma
RvEis is a crucial thermostable hexameric aminoglycoside acetyltransferase of Mycobacterium tuberculosis, overexpression of which confers Kanamycin resistance in clinical strains. The thermostability associated with hexameric RvEis is important for the enhanced intracellular survival of mycobacteria. However, the structural determinants responsible for its thermal stability remain unexplored. In this study, we have assessed the role of glycines of conserved glycine-rich motif (G123GIYG127) present at the oligomeric interface in the hydrophobic core of RvEis in sustenance of its structural stability, oligomerization and functional activity...
December 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29246267/autonomic-nervous-system-functioning-related-to-nocturnal-sleep-in-patients-with-chronic-fatigue-syndrome-compared-to-tired-controls
#11
Maija Orjatsalo, Anniina Alakuijala, Markku Partinen
STUDY OBJECTIVES: Autonomic nervous system (ANS) dysfunction is common in chronic fatigue syndrome (CFS). One of the main complaints in CFS is unrefreshing sleep. We aimed to study the nocturnal cardiac ANS in different sleep stages in patients filling the 2015 Institute of Medicine CFS diagnostic criteria. METHODS: In this case series study, the nocturnal heart rate variability and blood pressure (BP) variables in polysomnography were studied in groups of patients with CFS (n = 8) and tired controls (n = 8) aged 16-49 years...
December 13, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29245180/factors-influencing-cane-use-for-the-management-of-knee-osteoarthritis-a-cross-sectional-survey
#12
Julia Hart, Rana S Hinman, Ans Van Ginckel, Michelle Hall, Rachel Nelligan, Kim L Bennell
OBJECTIVE: To investigate demographic, symptom-related and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritise the factors that could facilitate cane use in people with no previous cane use. METHODS: A survey of people aged ≥45 years with a clinical diagnosis of knee OA was conducted. The survey included two sections: i) demographic and cognitive determinants of cane use assessed via subscales of the Cane Cognitive Mediator Scale; ii) 19 statements, underpinned by the Behaviour Change Wheel theoretical framework, relating to factors that could facilitate regular cane use...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29242602/altered-heart-rate-regulation-by-the-autonomic-nervous-system-in-mice-lacking-natriuretic-peptide-receptor-c-npr-c
#13
Motahareh Moghtadaei, Ellen Langille, Sara A Rafferty, Oleg Bogachev, Robert A Rose
Natriuretic peptides (NPs) play essential roles in the regulation of cardiovascular function. NP effects are mediated by receptors known as NPR-A, NPR-B or NPR-C. NPs have potent effects on regulation of heart rate (HR) by the autonomic nervous system (ANS), but the role of NPR-C in these effects has not been investigated. Accordingly, we have used telemetric ECG recordings in awake, freely moving wildtype and NPR-C knockout (NPR-C-/-) mice and performed heart rate variability (HRV) analysis to assess alterations in sympatho-vagal balance on the heart following loss of NPR-C...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239633/spatial-but-not-temporal-numerosity-thresholds-correlate-with-formal-math-skills-in-children
#14
Giovanni Anobile, Roberto Arrighi, Elisa Castaldi, Eleonora Grassi, Lara Pedonese, Paula A M Moscoso, David C Burr
Humans and other animals are able to make rough estimations of quantities using what has been termed the approximate number system (ANS). Much evidence suggests that sensitivity to numerosity correlates with symbolic math capacity, leading to the suggestion that the ANS may serve as a start-up tool to develop symbolic math. Many experiments have demonstrated that numerosity perception transcends the sensory modality of stimuli and their presentation format (sequential or simultaneous), but it remains an open question whether the relationship between numerosity and math generalizes over stimulus format and modality...
December 14, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29238330/an-assessment-of-different-genomic-approaches-for-inferring-phylogeny-of-listeria-monocytogenes
#15
Clémentine Henri, Pimlapas Leekitcharoenphon, Heather A Carleton, Nicolas Radomski, Rolf S Kaas, Jean-François Mariet, Arnaud Felten, Frank M Aarestrup, Peter Gerner Smidt, Sophie Roussel, Laurent Guillier, Michel-Yves Mistou, René S Hendriksen
Background/objectives: Whole genome sequencing (WGS) has proven to be a powerful subtyping tool for foodborne pathogenic bacteria like L. monocytogenes. The interests of genome-scale analysis for national surveillance, outbreak detection or source tracking has been largely documented. The genomic data however can be exploited with many different bioinformatics methods like single nucleotide polymorphism (SNP), core-genome multi locus sequence typing (cgMLST), whole-genome multi locus sequence typing (wgMLST) or multi locus predicted protein sequence typing (MLPPST) on either core-genome (cgMLPPST) or pan-genome (wgMLPPST)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237491/cost-effectiveness-of-enzyme-replacement-therapy-with-alglucosidase-alfa-in-adult-patients-with-pompe-disease
#16
Tim A Kanters, Ans T van der Ploeg, Michelle E Kruijshaar, Dimitris Rizopoulos, W Ken Redekop, Maureen P M H Rutten-van Mӧlken, Leona Hakkaart-van Roijen
BACKGROUND: Pompe disease is a rare, progressive, metabolic disease, and the first treatable inheritable muscle disorder. Enzyme replacement therapy (ERT) with alglucosidase alfa is disease specific and the only medicinal product authorized for the treatment of Pompe disease. Costs of ERT are very high as for most orphan drugs. This study investigates the cost-effectiveness of ERT compared to supportive treatment in adult patients with Pompe disease. METHODS: Survival probabilities were estimated from an international observational dataset (n = 283) using a time-dependent Cox model...
December 13, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29234894/amputation-neuroma-mimicking-lymph-node-metastasis-of-remnant-gastric-cancer-a-case-report
#17
Kenichiro Furukawa, Yutaka Tanizawa, Kimihide Kusafuka, Noriyuki Nishiwaki, Keiichi Fujiya, Hayato Omori, Sanae Kaji, Makoto Hikage, Rie Makuuchi, Tomoyuki Irino, Masanori Tokunaga, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: Amputation neuromas (ANs) are reactive hyperplasia of nerve tissues that occur after a trauma or surgery involving the peripheral nerves. Only two previous reports of ANs occurring around the stomach and post gastrectomy have been reported. We report the case of a patient with AN near the remnant stomach who underwent distal gastrectomy for gastric cancer. CASE PRESENTATION: A 76-year-old man underwent distal gastrectomy, D1+ lymphadenectomy, and Billroth-I reconstruction for early gastric cancer in another hospital at 63 years of age...
December 12, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29233092/heart-rate-variability-after-radiofrequency-ablation-of-epicardial-ganglionated-plexuses-on-the-ovine-left-atrium
#18
Vilius Kviesulaitis, Aras Puodziukynas, Dainius Haroldas Pauza, Vytautas Zabiela, Tomas Kazakevicius, Raimundas Vaitkevicius, Evaldas Diržinauskas, Vytenis Semaška, Antanas Strazdas, Ruta Unikaite, Kristina Rysevaite, Neringa Pauziene, Remigijus Zaliunas
BACKGROUND: Ganglionated plexuses (GP) are terminal parts of cardiac autonomous nervous system (ANS). Radiofrequency ablation (RFA) for atrial fibrillation (AF) possibly affects GP. Changes in heart rate variability (HRV) after RFA can reflect ANS modulation. METHODS: Epicardial RFA of GP on the left atrium (LA) was performed under the general anesthesia in 15 mature Romanov sheep. HRV was used to assess the alterations in autonomic regulation of the heart. A 24 - hour ECG monitoring was performed before the ablation, 2 days after it and at each of the 12 following months...
December 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29232439/body-mass-index-and-breast-cancer-survival-a-mendelian-randomization-analysis
#19
Qi Guo, Stephen Burgess, Constance Turman, Manjeet K Bolla, Qin Wang, Michael Lush, Jean Abraham, Kristiina Aittomäki, Irene L Andrulis, Carmel Apicella, Volker Arndt, Myrto Barrdahl, Javier Benitez, Christine D Berg, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Judith S Brand, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Carlos Caldas, Daniele Campa, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Fergus J Couch, Angela Cox, Simon S Cross, Cezary Cybulski, Kamila Czene, Hatef Darabi, Peter Devilee, W Ryan Diver, Alison M Dunning, Helena M Earl, Diana M Eccles, Arif B Ekici, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Henrik Flyger, Susan M Gapstur, Mia M Gaudet, Graham G Giles, Gord Glendon, Mervi Grip, Jacek Gronwald, Lothar Haeberle, Christopher A Haiman, Per Hall, Ute Hamann, Susan Hankinson, Jaana M Hartikainen, Alexander Hein, Louise Hiller, Frans B Hogervorst, Bernd Holleczek, Maartje J Hooning, Robert N Hoover, Keith Humphreys, David J Hunter, Anika Hüsing, Anna Jakubowska, Arja Jukkola-Vuorinen, Rudolf Kaaks, Maria Kabisch, Vesa Kataja, Julia A Knight, Linetta B Koppert, Veli-Matti Kosma, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Jan Lubinski, Mitchell J Machiela, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Federik Marme, John W M Martens, Catriona McLean, Primitiva Menéndez, Roger L Milne, Anna Marie Mulligan, Taru A Muranen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Børge G Nordestgaard, Janet E Olson, Jose I A Perez, Paolo Peterlongo, Kelly-Anne Phillips, Christopher J Poole, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Thomas Rüdiger, Anja Rudolph, Elinor J Sawyer, Fredrick Schumacher, Petra Seibold, Caroline Seynaeve, Mitul Shah, Ann Smeets, Melissa C Southey, Rob A E M Tollenaar, Ian Tomlinson, Helen Tsimiklis, Hans-Ulrich Ulmer, Celine Vachon, Ans M W van den Ouweland, Laura J Van't Veer, Hans Wildiers, Walter Willett, Robert Winqvist, M Pilar Zamora, Georgia Chenevix-Trench, Thilo Dörk, Douglas F Easton, Montserrat García-Closas, Peter Kraft, John L Hopper, Wei Zheng, Marjanka K Schmidt, Paul D P Pharoah
Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry...
December 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29226016/civic-engagement-and-political-participation-among-american-indians-and-alaska-natives-in-the-us
#20
Kimberly R Huyser, Gabriel R Sanchez, Edward D Vargas
Within the growing literature seeking to understand civic and political engagement among racial and ethnic minorities, our understanding of political behavior among American Indian and Alaska Native's (AI/AN) remains limited. We use the Current Population Survey Civic Engagement and Voting and Registration supplements (2006-2012) to compare AI/AN voter registration, voting, and overall civic engagement to other racial and ethnic groups and to assess whether factors that predict higher levels of civic engagement vary across these populations...
2017: Politics, Groups & Identities
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