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https://www.readbyqxmd.com/read/28936909/predictors-of-chronic-pain-following-total-knee-replacement-in-females-and-males-an-exploratory-study
#1
Tanja Bossmann, Torsten Brauner, Scott Wearing, Thomas Horstmann
AIM: This study explored whether nociceptive (NS) and autonomic nervous system (ANS) dysregulation and psychological distress were predictive of pain 6 months after primary total knee replacement. PATIENTS & METHODS: ANS and NS regulation, psychological distress and self-reported pain, stiffness and function were evaluated preoperatively in 56 patients. Pain severity measured 6 months after surgery was used as the primary outcome in an analysis of covariance model...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28936220/de-novo-assembly-of-the-camellia-nitidissima-transcriptome-reveals-key-genes-of-flower-pigment-biosynthesis
#2
Xingwen Zhou, Jiyuan Li, Yulin Zhu, Sui Ni, Jinling Chen, Xiaojuan Feng, Yunfeng Zhang, Shuangquan Li, Hongguang Zhu, Yuanguang Wen
The golden camellia, Camellia nitidissima Chi., is a well-known ornamental plant that is known as "the queen of camellias" because of its golden yellow flowers. The principal pigments in the flowers are carotenoids and flavonol glycosides. Understanding the biosynthesis of the golden color and its regulation is important in camellia breeding. To obtain a comprehensive understanding of flower development in C. nitidissima, a number of cDNA libraries were independently constructed during flower development. Using the Illumina Hiseq2500 platform, approximately 71...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28934908/characterization-of-methylglyoxal-modified-human-igg-by-physico-chemical-methods
#3
Mohd Adnan Khan, Zarina Arif, Moin Uddin, Khursheed Alam
Human IgG is a defence protein and quite reactive to dicarbonyls. In this study, methylglyoxal-induced modification of IgG was examined by various biochemical and biophysical methods. The methylglyoxal-induced changes in IgG were monitored by UV-visible and fluorescence spectroscopy, Fourier transform infrared spectroscopy, 1-anilinonaphthalene-8-sulfonic acid (ANS) and thermal denaturation studies. Aggregate formation was studied by Thioflavin T (ThT), Congo red (CR) and scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
September 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28932132/central-sensitization-based-classification-for-temporomandibular-disorders-a-pathogenetic-hypothesis
#4
REVIEW
Annalisa Monaco, Ruggero Cattaneo, Maria Chiara Marci, Davide Pietropaoli, Eleonora Ortu
Dysregulation of Autonomic Nervous System (ANS) and central pain pathways in temporomandibular disorders (TMD) is a growing evidence. Authors include some forms of TMD among central sensitization syndromes (CSS), a group of pathologies characterized by central morphofunctional alterations. Central Sensitization Inventory (CSI) is useful for clinical diagnosis. Clinical examination and CSI cannot identify the central site(s) affected in these diseases. Ultralow frequency transcutaneous electrical nerve stimulation (ULFTENS) is extensively used in TMD and in dental clinical practice, because of its effects on descending pain modulation pathways...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28926794/depression-recognition-according-to-heart-rate-variability-using-bayesian-networks
#5
Danni Kuang, Rongqian Yang, Xiuwen Chen, Guohui Lao, Fengchun Wu, Xiong Huang, Ruixue Lv, Lei Zhang, Chuanxu Song, Shanxing Ou
BACKGROUND: Doctors mainly use scale tests and subjective judgment in the clinical diagnosis of depression. Researches have demonstrated that depression is associated with the dysfunction of the autonomic nervous system (ANS), where its modulation can be evaluated by heart rate variability (HRV). Depression patients have lower HRV than healthy subjects. Therefore, HRV may be used to distinguish depression patients from healthy people. METHODS: HRV signals were collected from 76 female subjects composed of 38 depression patients and 38 healthy people...
September 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28925865/structural-changes-of-human-serum-albumin-hsa-in-simulated-microgravity
#6
Azadeh Hekmat, Zahra Hajebrahimi, Amir Motamedzade
Nowadays, the biological effects of microgravity have been the subject of various experimental researches. The purpose of this study was to investigate the probable biological effects of microgravity on the human serum albumin (HSA) structure after 3 and 24 h exposure via various spectroscopic instruments. The UV-Visible, near-UV-CD and intrinsic fluorescence spectroscopy represented that microgravity can remarkably change the tertiary structure of HSA. Additionally, the ANS affinity for HSA incremented when the protein was exposed to simulate microgravity compared to unexposed HSA, which may possibly have appeared attributable to expansion of the structure of simulated HSA...
September 17, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28922112/effects-of-flexible-dry-electrode-design-on-electrodermal-activity-stimulus-response-detection
#7
Peter A Haddad, Amir Servati, Saeid Soltanian, Frank Ko, Peyman Servati
OBJECTIVE: The focus of this research is to evaluate the effects of design parameters including surface area, distance between and geometry of dry flexible electrodes on electrodermal activity (EDA) stimulus response detection. METHODS: EDA is a result of the autonomic nervous system (ANS) being stimulated, which causes sweat and changes the electrical characteristics of the skin. Standard silver/silver chloride (Ag/AgCl) EDA electrodes are rigid and lack conformability in contact with skin...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28919529/acetylation-of-lysine-residues-in-apomyoglobin-structural-changes-amyloid-fibrillation-and-role-of-surface-charge
#8
Mehrnaz Azami-Movahed, Ali Akbar Meratan, Atiyeh Ghasemi, Azadeh Ebrahim-Habibi, Mohsen Nemat-Gorgani
Post-translational modifications play important roles in conformational properties and aggregation propensities of different peptides and proteins. In the present study, we have investigated the effects of acetylation of lysine residues on the structure and aggregation properties of apomyoglobin (apoMb).All of the 19 lysine residues were modified. Far-, near-UV CD, intrinsic and acrylamide quenching fluorescence studies indicated that acetylation significantly influences conformation of apoMb by altering both its secondary and tertiary structures...
September 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28912251/neuro-immune-interaction-and-the-regulation-of-intestinal-immune-homeostasis
#9
Simon Verheijden, Guy E Boeckxstaens
Many essential gastrointestinal functions, including motility, secretion and blood flow are regulated by the autonomic nervous system (ANS), both through intrinsic enteric neurons and extrinsic (sympathetic and parasympathetic) innervation. Recently identified neuro-immune mechanisms, in particular the interplay between enteric neurons and muscularis macrophages, are now considered to be essential for fine-tuning peristalsis. These findings shed new light on how intestinal immune cells can support enteric nervous function...
September 14, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28911792/facial-profile-and-frontal-changes-after-bimaxillary-surgery-in-patients-with-mandibular-prognathism
#10
Chun-Ming Chen, Michael Yuan-Chien Chen, Jung-Hsuan Cheng, Kwei-Jing Chen, Yu-Chuan Tseng
BACKGROUND/PURPOSE: Patients are always concerned about their postoperative appearance before surgery for facial deformity correction. The present study investigated the facial profile and frontal changes following two-jaw surgery. METHODS: Forty patients who underwent two-jaw surgery were divided by the amount of mandibular setback (group I: ≤8 mm and group II: >8 mm). Cephalometric radiograms (lateral and frontal) were collected and analyzed at three intervals: preoperatively (T1), immediately postoperatively (T2), and final follow-up (T3)...
September 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28905882/identification-of-causative-variants-in-txnl4a-in-burn-mckeown-syndrome-and-isolated-choanal-atresia
#11
Jacqueline A C Goos, Sigrid M A Swagemakers, Stephen R F Twigg, Marieke F van Dooren, A Jeannette M Hoogeboom, Christian Beetz, Sven Günther, Frank J Magielsen, Charlotte W Ockeloen, Maria A Ramos-Arroyo, Rolph Pfundt, Helger G Yntema, Peter J van der Spek, Philip Stanier, Dagmar Wieczorek, Andrew O M Wilkie, Ans M W van den Ouweland, Irene M J Mathijssen, Jane A Hurst
Burn-McKeown syndrome (BMKS) is a rare syndrome characterized by choanal atresia, prominent ears, abnormalities of the outer third of the lower eyelid, structural cardiac abnormalities, conductive and sensorineural hearing loss, and cleft lip. Recently, causative compound heterozygous variants were identified in TXNL4A. We analyzed an individual with clinical features of BMKS and her parents by whole-genome sequencing and identified compound heterozygous variants in TXNL4A (a novel splice site variant (c.258-2A>G, (p...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28898715/cortisol-and-salivary-alpha-amylase-trajectories-following-a-group-social-evaluative-stressor-with-adolescents
#12
Deirdre A Katz, Melissa K Peckins
Intraindividual variability in stress responsivity and the interrelationship of multiple neuroendocrine systems make a multisystem analytic approach to examining the human stress response challenging. The present study makes use of an efficient social-evaluative stress paradigm - the Group Public Speaking Task for Adolescents (GPST-A) - to examine the hypothalamic-pituitary-adrenocortical (HPA)-axis and Autonomic Nervous System (ANS) reactivity profiles of 54 adolescents with salivary cortisol and salivary alpha-amylase (sAA)...
August 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28895492/low-cardiac-vagal-tone-index-by-heart-rate-variability-differentiates-bipolar-from-major-depression
#13
Brandon Hage, Briana Britton, David Daniels, Keri Heilman, Stephen W Porges, Angelos Halaris
OBJECTIVES: Major depressive disorder (MDD) and depression in bipolar disorder (BD) are often difficult to distinguish from each other. Autonomic nervous system (ANS) dysregulation is associated with various depressive symptoms and inflammatory response disinhibition. The beat-to-beat pattern of heart rate (Heart Rate Variability) (HRV) offers a noninvasive portal to ANS function and provides a reliable index of resting cardiac vagal tone. We quantified HRV and measured inflammatory biomarkers in MDD and BD patients in an effort to derive potential diagnostic criteria for MDD and BD...
September 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28894928/enhanced-dendritic-cells-and-regulatory-t-cells-in-the-dermis-of-porokeratosis
#14
Kanako Matsuyama, Yoko Mizutani, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS)...
September 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28885552/structure-of-pigment-metabolic-pathways-and-their-contributions-to-white-tepal-color-formation-of-chinese-narcissus-tazetta-var-chinensis-cv-jinzhanyintai
#15
Yujun Ren, Jingwen Yang, Bingguo Lu, Yaping Jiang, Haiyang Chen, Yuwei Hong, Binghua Wu, Ying Miao
Chinese narcissus (Narcissus tazetta var. chinensis) is one of the ten traditional flowers in China and a famous bulb flower in the world flower market. However, only white color tepals are formed in mature flowers of the cultivated varieties, which constrains their applicable occasions. Unfortunately, for lack of genome information of narcissus species, the explanation of tepal color formation of Chinese narcissus is still not clear. Concerning no genome information, the application of transcriptome profile to dissect biological phenomena in plants was reported to be effective...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28884808/fraction-magnitude-understanding-and-its-unique-role-in-predicting-general-mathematics-achievement-at-two-early-stages-of-fraction-instruction
#16
Yingyi Liu
BACKGROUND: Prior studies on fraction magnitude understanding focused mainly on students with relatively sufficient formal instruction on fractions whose fraction magnitude understanding is relatively mature. AIM: This study fills a research gap by investigating fraction magnitude understanding in the early stages of fraction instruction. It extends previous findings to children with limited and primary formal fraction instruction. SAMPLE(S): Thirty-five fourth graders with limited fraction instruction and forty fourth graders with primary fraction instruction were recruited from a Chinese primary school...
September 8, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28880899/effects-of-sedation-on-subjective-perception-of-pain-intensity-and-autonomic-nervous-responses-to-pain-a-preliminary-study
#17
Hongling Kang, Aya Nakae, Hiroshi Ito, Piyasak Vitayaburananont, Takehiro Minamoto, Takashi Ikeda, Mariko Osaka, Takashi Mashimo, Yuji Fujino, Satoshi Hagihira
Rather than relying solely on subjective pain evaluation using means such as the visual analogue scale (VAS), in clinical situations it is possible to observe evoked responses of the autonomic nervous system (ANS) as objective indicators. Few studies, however, have reported these relationships under finely controlled sedation. 16 healthy male participants were administrated in intravenous sedation with either propofol or midazolam randomly. We initially determined, using pharmacokinetic simulation, the effect-site concentration (Ce) of anaesthetic at loss of response to verbal command and eyelash reflex (Ce-LOR)...
2017: PloS One
https://www.readbyqxmd.com/read/28875885/a-review-of-antenatal-corticosteroid-use-in-premature-neonates-in-a-middle-income-country
#18
A Laher, D E Ballot, T Ramdin, T Chirwa
BACKGROUND: Antenatal corticosteroid (ANS) use in premature neonates has become a standard of practice. However, there is low ANS coverage in low- to middle-income countries (LMICs). Recent studies have questioned the efficacy of ANSs in such countries. OBJECTIVE: To review the use of ANSs in preterm neonates at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), South Africa. METHODS: This was a retrospective observational study of all neonates with a birth weight of 500 - 1 800 g born at CMJAH between 1 January 2013 and 30 June 2016...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28873694/predicting-consumer-liking-and-preference-based-on-emotional-responses-and-sensory-perception-a-study-with-basic-taste-solutions
#19
Shilpa S Samant, Matthew J Chapko, Han-Seok Seo
Traditional methods of sensory testing focus on capturing information about multisensory perceptions, but do not necessarily measure emotions elicited by these food and beverages. The objective of this study was to develop an optimum model of predicting overall liking (rating) and preference (choice) based on taste intensity and evoked emotions. One hundred and two participants (51 females) were asked to taste water, sucrose, citric acid, salt, and caffeine solutions. Their emotional responses toward each sample were measured by a combination of a self-reported emotion questionnaire (EsSense25), facial expressions, and autonomic nervous system (ANS) responses...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28872299/comparison-of-%C3%AE-synuclein-fibril-inhibition-by-four-different-amyloid-inhibitors
#20
Narendra Nath Jha, Rakesh Kumar, Rajlaxmi Panigrahi, Ambuja Navalkar, Dhiman Ghosh, Shruti Sahay, Mrityunjoy Mondal, Ashutosh Kumar, Samir K Maji
Aggregation of α-synuclein (α-Syn) into toxic oligomers and fibrils leads to Parkinson's disease (PD) pathogenesis. Molecules that can inhibit the fibrillization and oligomerization of α-Syn have potential therapeutic value. Here, we studied four selective amyloid inhibitors: Dopamine (Dopa), Amphotericin-B (Amph), Epigallocatechingallate (EGCG) and Quinacrinedihydrochloride (Quin) for their effect on oligomerization, fibrillization and preformed fibrils of α-Syn. The aggregation kinetics of α-Syn using ThT fluorescence and conformational transition by circular dichroism (CD) in the presence and absence of these four compounds suggest that, except Quin, remaining three molecules inhibit α-Syn aggregation in concentration dependent manner...
September 5, 2017: ACS Chemical Neuroscience
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