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https://www.readbyqxmd.com/read/27911325/autonomic-nervous-system-dysfunctions-as-a-basis-for-a-predictive-model-of-risk-of%C3%A2-neurological-disorders-in-subjects-with%C3%A2-prior-history-of-traumatic-brain-injury-implications-in-alzheimer-s-disease
#1
Lap Ho, Marc Legere, Tongbin Li, Samara Levine, Ke Hao, Breanna Valcarcel, Giulio M Pasinetti
Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease (AD) are also implicated in the central autonomic nervous system (ANS) regulation. For example, deficits in central cholinergic function in AD could likely lead to autonomic dysfunction. We recently developed a simple, readily applicable evaluation for monitoring ANS disturbances in response to traumatic brain injury (TBI)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909347/cancer-among-american-indians-identifying-priority-areas-in-oklahoma
#2
Sydney A Martinez, Amanda E Janitz, Julie Erb-Alvarez, Dana S Mowls, Janis E Campbell, Tom Anderson
BACKGROUND: We describe and compare cancer incidence and mortality among American Indians (AI/ANs) and whites in nine Indian Health Service (IHS) Service Units in Oklahoma. METHODS: Using data from the Oklahoma Central Cancer Registry and the web-based OK2SHARE database, we obtained age-adjusted cancer incidence rates from 1997 to 2012 and cancer mortality rates from 1999 to 2009 for AI/ANs and whites in Oklahoma. We examined differences in primary site, percentage of late stage diagnoses, and trends over time...
July 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27895588/influence-of-heart-rate-in-non-linear-hrv-indices-as-a-sampling-rate-effect-evaluated-on-supine-and-standing
#3
Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón
The purpose of this study is to characterize and attenuate the influence of mean heart rate (HR) on nonlinear heart rate variability (HRV) indices (correlation dimension, sample, and approximate entropy) as a consequence of being the HR the intrinsic sampling rate of HRV signal. This influence can notably alter nonlinear HRV indices and lead to biased information regarding autonomic nervous system (ANS) modulation. First, a simulation study was carried out to characterize the dependence of nonlinear HRV indices on HR assuming similar ANS modulation...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27895475/transcranial-direct-current-stimulation-improves-the-qt-variability-index-and-autonomic-cardiac-control-in-healthy-subjects-older-than-60-years
#4
Gianfranco Piccirillo, Cristina Ottaviani, Claudia Fiorucci, Nicola Petrocchi, Federica Moscucci, Claudia Di Iorio, Fabiola Mastropietri, Ilaria Parrotta, Matteo Pascucci, Damiano Magrì
BACKGROUND: Noninvasive brain stimulation technique is an interesting tool to investigate the causal relation between cortical functioning and autonomic nervous system (ANS) responses. OBJECTIVE: The objective of this report is to evaluate whether anodal transcranial direct current stimulation (tDCS) over the temporal cortex influences short-period temporal ventricular repolarization dispersion and cardiovascular ANS control in elderly subjects. SUBJECTS AND METHODS: In 50 healthy subjects (29 subjects younger than 60 years and 21 subjects older than 60 years) matched for gender, short-period RR and systolic blood pressure spectral variability, QT variability index (QTVI), and noninvasive hemodynamic data were obtained during anodal tDCS or sham stimulation...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27891327/analysis-of-fetal-palate-to-assist-pre-natal-ultrasound
#5
Anjali Shastry, Yogitha Ravindranath, Roopa Ravindranath
INTRODUCTION: Cleft palate is one of the major facial congenital malformation in newborns. Pre-natal detection of this malformation is limited to detection of clefting of hard palate but isolated soft palate clefting still remains challenge for sonologists. As Indian literature is limited present study was attempted to provide dimensions and position of fetal palate by digitized images. AIM: To study dimensions, position and differences in parameters between second and third trimester fetuses...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27881783/multivariate-brain-prediction-of-heart-rate-and-skin-conductance-responses-to-social-threat
#6
Hedwig Eisenbarth, Luke J Chang, Tor D Wager
: Psychosocial stressors induce autonomic nervous system (ANS) responses in multiple body systems that are linked to health risks. Much work has focused on the common effects of stress, but ANS responses in different body systems are dissociable and may result from distinct patterns of cortical-subcortical interactions. Here, we used machine learning to develop multivariate patterns of fMRI activity predictive of heart rate (HR) and skin conductance level (SCL) responses during social threat in humans (N = 18)...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27880695/the-association-of-birth-weight-and-infant-growth-with-childhood-autonomic-nervous-system-activity-and-its-mediating-effects-on-energy-balance-related-behaviours-the-abcd-study
#7
Arend W van Deutekom, Mai Jm Chinapaw, Maaike Gj Gademan, Jos Wr Twisk, Reinoud Jbj Gemke, Tanja Gm Vrijkotte
BACKGROUND: The purpose of this study was to examine the association of birth weight and infant growth with childhood autonomic nervous system (ANS) activity and to assess whether ANS activity mediates the associations of birth weight and infant growth with energy-balance-related behaviours, including energy intake, satiety response, physical activity and screen time. METHODS: In 2089 children, we prospectively collected birth weight, infant growth defined as conditional weight and height gain between birth and 12 months and-at 5 years-indices of cardiac ANS activity and parent-reported energy-balance-related behaviours...
August 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27876406/adenotonsillectomy-can-decrease-enuresis-and-sympathetic-nervous-activity-in-children-with-obstructive-sleep-apnea-syndrome
#8
Hao Ding, Mengmei Wang, Ke Hu, Jing Kang, Si Tang, Wen Lu, Lifang Xu
BACKGROUND: The nocturnal intermittent hypoxia caused by obstructive sleep apnea syndrome (OSAS) can provoke the sympathetic nervous activity (SNA). Salivary alpha-amylase (sAA) is a sensitive, non-invasive biomarker for reflecting the SNA, and a useful marker for pediatric OSAS subjects. Adenotonsillar hypertrophy (ATH) is the most commonly identified risk factor in OSAS childhood, therefore, several studies showed that the adenotonsillectomy (T&A) may alleviate nocturnal enuresis (NE) in children with OSAS...
November 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27875744/identification-of-protein-secondary-structures-by-laser-induced-autofluorescence-a-study-of-urea-and-gnhcl-induced-protein-denaturation
#9
Manjunath Siddaramaiah, Kapaettu Satyamoorthy, Bola Sadashiva Satish Rao, Suparna Roy, Subhash Chandra, Krishna Kishore Mahato
In the present study an attempt has been made to interrogate the bulk secondary structures of some selected proteins (BSA, HSA, lysozyme, trypsin and ribonuclease A) under urea and GnHCl denaturation using laser induced autofluorescence. The proteins were treated with different concentrations of urea (3M, 6M, 9M) and GnHCl (2M, 4M, 6M) and the corresponding steady state autofluorescence spectra were recorded at 281nm pulsed laser excitations. The recorded fluorescence spectra of proteins were then interpreted based on the existing PDB structures of the proteins and the Trp solvent accessibility (calculated using "Scratch protein predictor" at 30% threshold)...
November 14, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27875540/improving-preschoolers-arithmetic-through-number-magnitude-training-the-impact-of-non-symbolic-and-symbolic-training
#10
Nastasya Honoré, Marie-Pascale Noël
The numerical cognition literature offers two views to explain numerical and arithmetical development. The unique-representation view considers the approximate number system (ANS) to represent the magnitude of both symbolic and non-symbolic numbers and to be the basis of numerical learning. In contrast, the dual-representation view suggests that symbolic and non-symbolic skills rely on different magnitude representations and that it is the ability to build an exact representation of symbolic numbers that underlies math learning...
2016: PloS One
https://www.readbyqxmd.com/read/27875235/concept-factorization-with-adaptive-neighbors-for-document-clustering
#11
Xiaobing Pei, Chuanbo Chen, Weihua Gong
In this paper, a novel concept factorization (CF) method, called CF with adaptive neighbors (CFANs), is proposed. The idea of CFAN is to integrate an ANs regularization constraint into the CF decomposition. The goal of CFAN is to extract the representation space that maintains geometrical neighborhood structure of the data. Similar to the existing graph-regularized CF, CFAN builds a neighbor graph weights matrix. The key difference is that the CFAN performs dimensionality reduction and finds the neighbor graph weights matrix simultaneously...
November 18, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27872322/hiv-care-and-treatment-of-american-indians-alaska-natives-with-diagnosed-hiv-infection-27-states-and-the-district-of-columbia-2012
#12
Andrew Mitsch, Aruna Surendera Babu, Dean Seneca, Y Omar Whiteside, Donald Warne
The objective of this study was to measure linkage to care, retention in care, and suppressed viral load (VL) among American Indians/Alaska Natives (AIs/ANs) aged ≥13 years with diagnosed HIV infection. We used national HIV case surveillance data to measure linkage to care, defined as ≥1 CD4 or VL test ≤1 month after HIV diagnosis during 2013; retention in care, defined as ≥2 CD4 or VL tests ≥3 months apart during 2012; and suppressed VL, defined as <200 copies/mL at the most recent VL test during 2012...
November 21, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27871792/dual-inhibition-of-bace1-and-a%C3%AE-aggregation-by-%C3%AE-ecdysone-application-of-a-phytoecdysteroid-scaffold-in-alzheimer-s-disease-therapeutics
#13
Sandipan Chakraborty, Soumalee Basu
Current medications for the complex neurological disorder, Alzheimer's disease (AD), can neither stop disease progression nor revert back disease pathogenesis. The present study demonstrates the applicability of a phytoecdysteroid, β-ecdysone, as a multi-potent agent in AD therapeutics. β-ecdysone strongly binds to the active site cavity of BACE1 with calculated dissociation constant of 1.75±0.1μM. Steady-state and time-resolved fluorescence spectroscopy reveal that binding of β-ecdysone induces conformational transition of the protein from open to closed form thereby blocking substrate binding...
November 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27866807/genome-wide-analysis-of-the-nucleus-accumbens-identifies-dna-methylation-signals-differentiating-low-binge-from-heavy-alcohol-drinking
#14
Rita Cervera-Juanes, Larry J Wilhelm, Byung Park, Kathleen A Grant, Betsy Ferguson
Alcohol use disorders encompass a range of drinking levels and behaviors, including low, binge and heavy drinking. In this regard, investigating the neural state of individuals who chronically self-administer lower doses of alcohol may provide insight into mechanisms that prevent the escalation of alcohol use. DNA methylation is one of the epigenetic mechanisms that stabilizes adaptations in gene expression and has been associated with alcohol use. Thus, we investigated DNA methylation, gene expression and the predicted neural effects in the nucleus accumbens core (NAcc) of male rhesus macaques categorized as "low" or "binge" drinkers, compared to "alcohol-naïve" and "heavy" drinkers based on drinking patterns during a 12 month alcohol self-administration protocol...
November 10, 2016: Alcohol
https://www.readbyqxmd.com/read/27858873/dexrazoxane-improves-cardiac-autonomic-function-in-epirubicin-treated-breast-cancer-patients-with-type-2-diabetes
#15
Fangyi Sun, Jing Shi, Cuizhi Geng
OBJECTIVE: The study objective was to investigate the protective effects of dexrazoxane (DRZ) on the cardiac autonomic nervous system (ANS) activity in anthracycline-treated breast cancer patients with diabetes. METHODS: A total of 110 early stage breast cancer patients with type 2 diabetes were divided randomly into 2 even groups: chemotherapy alone (Chemo) and chemotherapy + DRZ (Chemo + DRZ). All patients underwent adjuvant chemotherapy (80 mg/m epirubicin and 500 mg/m cyclophosphamide) for a total of 6 cycles with 21 days/cycle...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858112/effects-of-sabbagh-universal-spring-2-fixed-functional-appliance-on-class-ii-1-patients-at-their-postpubertal-peak-growth-period-compared-with-the-extraction-method-a-randomized-clinical-trial
#16
Siamak Hemmatpour, Ali Mokhtar, Vahid Rakhshan
OBJECTIVE: The aim of this study was to evaluate the therapeutic effects of the Sabbagh Universal Spring 2 (SUS 2) fixed functional appliance compared to the premolar extraction method in correcting class II/1 malocclusion in patients who had passed their peak of postpubertal growth (stages 4-6 of Cervical Vertebral Maturation Index). METHODS: In all, 40 class II/1 patients were randomized to receive SUS 2 application (7 males, 13 females, age 15.75 ± 1.02 years) or maxillary premolar extraction (8 males, 12 females, age 15...
November 17, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27853259/comparative-transcriptome-analysis-of-chinary-assamica-and-cambod-tea-camellia-sinensis-types-during-development-and-seasonal-variation-using-rna-seq-technology
#17
Ajay Kumar, Vandna Chawla, Eshita Sharma, Pallavi Mahajan, Ravi Shankar, Sudesh Kumar Yadav
Tea quality and yield is influenced by various factors including developmental tissue, seasonal variation and cultivar type. Here, the molecular basis of these factors was investigated in three tea cultivars namely, Him Sphurti (H), TV23 (T), and UPASI-9 (U) using RNA-seq. Seasonal variation in these cultivars was studied during active (A), mid-dormant (MD), dormant (D) and mid-active (MA) stages in two developmental tissues viz. young and old leaf. Development appears to affect gene expression more than the seasonal variation and cultivar types...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852594/hip-strength-as-an-intrinsic-risk-factor-for-lateral-ankle-sprains-in-youth-soccer-players-a-3-season-prospective-study
#18
Roel De Ridder, Erik Witvrouw, Mieke Dolphens, Philip Roosen, Ans Van Ginckel
BACKGROUND: Numerous epidemiological studies have emphasized the burden of lateral ankle sprains in youth soccer players. However, no prospective study has identified intrinsic physical and modifiable risk factors for these injuries in this particular population. Although injury prevention programs in soccer incorporate proximal hip and core stability exercises, it is striking that the relationship between impaired proximal hip function and ankle sprains has not yet been prospectively investigated in youth soccer players...
November 16, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27849113/late-night-exercise-affects-the-autonomic-nervous-system-activity-but-not-the-hypothalamo-pituitary-adrenal-axis-in-the-next-morning
#19
Cihat Ucar, Tuba Özgöçer, Sedat Yildiz
BACKGROUND: Exercise activates hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS) and generally causes beneficial changes in homeostatic balance. However, the health benefits of late-night exercise programs on the activity of HPA and ANS is not known. The aim of this study was to assess effects of late-night exercise on sleep quality and on the activities of the HPA axis (as cortisol awakening response, CAR) and the ANS (as heart rate variability, HRV) measurements in the following morning...
November 16, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27845421/rs2735383-located-at-a-microrna-binding-site-in-the-3-utr-of-nbs1-is-not-associated-with-breast-cancer-risk
#20
Jingjing Liu, Ivona Lončar, J Margriet Collée, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Irene L Andrulis, Monica Barile, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang-Claude, Shou-Tung Chen, Georgia Chenevix-Trench, Ching Y Cheng, Ji-Yeob Choi, Fergus J Couch, Angela Cox, Simon S Cross, Katarina Cuk, Kamila Czene, Thilo Dörk, Isabel Dos-Santos-Silva, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G Giles, Gord Glendon, Mark S Goldberg, Anna González-Neira, Pascal Guénel, Christopher A Haiman, Ute Hamann, Steven N Hart, Mikael Hartman, Sigrid Hatse, John L Hopper, Hidemi Ito, Anna Jakubowska, Maria Kabisch, Daehee Kang, Veli-Matti Kosma, Vessela N Kristensen, Loic Le Marchand, Eunjung Lee, Jingmei Li, Artitaya Lophatananon, Jan Lubinski, Arto Mannermaa, Keitaro Matsuo, Roger L Milne, Susan L Neuhausen, Heli Nevanlinna, Nick Orr, Jose I A Perez, Julian Peto, Thomas C Putti, Katri Pylkäs, Paolo Radice, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Andreas Schneeweiss, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Anthony Swerdlow, Soo H Teo, Daniel C Tessier, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Celine Vachon, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Wei Zheng, Per Hall, Alison M Dunning, Douglas F Easton, Maartje J Hooning, Ans M W van den Ouweland, John W M Martens, Antoinette Hollestelle
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1...
November 15, 2016: Scientific Reports
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