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https://www.readbyqxmd.com/read/28635083/clinically-distinct-trajectories-of-fatigue-and-their-longitudinal-relationship-with-the-disturbance-of-personal-goals-following-a-cancer-diagnosis
#1
Fabiola Müller, Marrit A Tuinman, Moniek Janse, Josué Almansa, Mirjam A G Sprangers, Ans Smink, Adelita V Ranchor, Joke Fleer, Mariët Hagedoorn
OBJECTIVES: Most studies on fatigue in patients with cancer aggregate its prevalence and severity on a group level, ignoring the possibility that subgroups of patients may differ widely in their development of fatigue. This study aimed to identify subgroups of patients with clinically distinct trajectories of fatigue from diagnosis to 18 months post-diagnosis. As fatigue might trigger goal disturbance, the study also identified trajectories of concrete and abstract goal disturbance and longitudinally examined their co-occurrence with fatigue...
June 21, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28633822/effects-of-pulsed-ultrasound-on-rheological-and-structural-properties-of-chicken-myofibrillar-protein
#2
Jing-Yu Wang, Yu-Ling Yang, Xiao-Zhi Tang, Wen-Xi Ni, Lei Zhou
The effects of pulsed ultrasound (PUS) (power: 240w) with varying time (0, 3, 6, 9, 12 and 15min) on rheological and structural properties of chicken myofibrillar protein (CMP) were examined. PUS treatment significantly caused a decrease in the viscosity coefficients (k) but an increase in the flow index (n) value of CMP solutions within short time (0-6min), while had no significant effect for longer time (9-15min). Besides, at 6min, the solubility and microstructure of CMP samples were optimum. The primary structure of CMP was not altered by PUS treatment...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28628383/cardiovascular-response-of-an-acute-exergame-session-in-prepubertal-obese-children
#3
Herikson Araújo Costa, Antonio Carlos Silva-Filho, Carlos José Dias, Vicenilma Andrade Martins, Thiago Mendes, André Rabelo, Francisco Navarro, Emerson Silami-Garcia, Cristiano Mostarda, Mario Sevílio
PURPOSE: We aimed to analyze the acute autonomic response of obese and eutrophic prepubertal boys to an exergame (EXG) session. MATERIALS AND METHOD: Nine eutrophic (8.89 ± 2.71 years of age and 16.42% ± 6.30% body fat) and nine obese boys (8.70 ± 1.16 years of age and 40.76% ± 4.2% body fat) participated. Nutritional state was determined using World Health Organization guidelines. Variables were collected at rest, immediately post (IP), and 60 minutes after a 20 minutes EXG session...
June 2017: Games for Health
https://www.readbyqxmd.com/read/28624228/antisense-oligonucleotides-promote-exon-inclusion-and-correct-the-common-c-32-13t-g-gaa-splicing-variant-in-pompe-disease
#4
Erik van der Wal, Atze J Bergsma, Joon M Pijnenburg, Ans T van der Ploeg, W W M Pim Pijnappel
The most common variant causing Pompe disease is c.-32-13T>G (IVS1) in the acid α-glucosidase (GAA) gene, which weakens the splice acceptor of GAA exon 2 and induces partial and complete exon 2 skipping. It also allows a low level of leaky wild-type splicing, leading to a childhood/adult phenotype. We hypothesized that cis-acting splicing motifs may exist that could be blocked using antisense oligonucleotides (AONs) to promote exon inclusion. To test this, a screen was performed in patient-derived primary fibroblasts using a tiling array of U7 small nuclear RNA (snRNA)-based AONs...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28624186/gaa-deficiency-in-pompe-disease-is-alleviated-by-exon-inclusion-in-ipsc-derived-skeletal-muscle-cells
#5
Erik van der Wal, Atze J Bergsma, Tom J M van Gestel, Stijn L M In 't Groen, Holm Zaehres, Marcos J Araúzo-Bravo, Hans R Schöler, Ans T van der Ploeg, W W M Pim Pijnappel
Pompe disease is a metabolic myopathy caused by deficiency of the acid α-glucosidase (GAA) enzyme and results in progressive wasting of skeletal muscle cells. The c.-32-13T>G (IVS1) GAA variant promotes exon 2 skipping during pre-mRNA splicing and is the most common variant for the childhood/adult disease form. We previously identified antisense oligonucleotides (AONs) that promoted GAA exon 2 inclusion in patient-derived fibroblasts. It was unknown how these AONs would affect GAA splicing in skeletal muscle cells...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28620054/an-assessment-of-the-autonomic-nervous-system-in-the-electrohypersensitive-population-a-heart-rate-variability-and-skin-conductance-study
#6
Soafara Andrianome, Jonathan Gobert, Laurent Hugueville, Erwan Stéphan-Blanchard, Frederic Telliez, Brahim Selmaoui
The aim of the study was twofold: first, to compare the activity of the autonomic nervous system (ANS) between the population self-declared as electrohypersensitive (EHS) and their matched control individuals without intended exposure to electromagnetic fields (EMF). The second objective was to determine whether acute exposure to different radiofrequency signals modifies ANS activity in EHS. For that purpose, two different experiments were undertaken, in which ANS activity was assessed through heart rate variability (HRV) and skin conductance (SC)...
June 15, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28616855/respiratory-sinus-arrhythmia-predicts-restricted-repetitive-behavior-severity
#7
Emma E Condy, Angela Scarpa, Bruce H Friedman
In addition to social communication deficits, restricted repetitive behaviors (RRBs) are a key diagnostic feature of autism spectrum disorder (ASD). Dysfunction of the autonomic nervous system (ANS) in ASD has been posited as a mechanism of RRBs; however, most studies investigating ANS activity in ASD have focused on its relation to social functioning. This study used respiratory sinus arrhythmia (RSA) patterns to measure ANS functioning and analyze its relation to RRBs in children with and without an ASD diagnosis...
June 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28616394/new-method-of-sudomotor-function-measurement-to-detect-microvascular-disease-and-sweat-gland-nerve-or-unmyelinated-c-fiber-dysfunction-in-adults-with-retinopathy
#8
John E Lewis, Steven E Atlas, Ammar Rasul, Ashar Farooqi, Laura Lantigua, Oscar L Higuera, Andrea Fiallo, Lianette Laria, Renata Picciani, Ken Wals, Zohar Yehoshua, Armando Mendez, Janet Konefal, Sharon Goldberg, Judi Woolger
BACKGROUND: Diabetes-associated microvascular complications such as retinopathy and neuropathy often lead to end-organ and tissue damage. Impaired skin microcirculation often precedes the detection of other advanced diabetic complications. The ANS-1 system contains a redesigned sympathetic skin response (ANS-1 SSR) device that measures sudomotor function, a photoplethysmography sensor, and a blood pressure device to comprehensively assess cardiac autonomic neuropathy and endothelial dysfunction...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28612516/autonomic-nervous-system-function-in-adolescent-migraineurs
#9
Seiji Yoshida, Hidetaka Tanaka, Midori Mizutani, Ryota Nakao, Naoyuki Okamoto, Mitsugu Kajiura, Yukiko Kanbara, Hiroshi Tamai
BACKGROUND: Migraine is a common and disabling neurological disorder. Studies attempting to determine a relationship between migraine and the autonomic nervous system (ANS) have been inconclusive. Moreover, pediatric studies are extremely limited. Therefore, the present study investigated interictal ANS function in adolescent migraineurs. METHODS: We studied 21 patients with migraine and 26 healthy controls. Beat-to-beat blood pressure (BP) and heart rate (HR) were noninvasively and continuously measured in the supine and standing positions...
June 14, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28611608/coping-style-modifies-general-and-affective-autonomic-reactions-of-domestic-pigs-in-different-behavioral-contexts
#10
Annika Krause, Birger Puppe, Jan Langbein
Based on individual adaptive strategies (coping), animals may react differently to environmental challenges in terms of behavior and physiology according to their emotional perception. Emotional valence as well as arousal may be derived by measuring vagal and sympathetic tone of the autonomic nervous system (ANS). We investigated the situation-dependent autonomic response of 16 domestic pigs with either a reactive or a proactive coping style, previously selected according to the backtest which is accepted in piglets to assess escape behavior...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28602714/functional-analysis-of-bas2108-2109-two-component-system-evidence-for-protease-regulation-in-bacillus-anthracis
#11
Vatika Gupta, Neha Chaudhary, Somya Aggarwal, Nidhi Adlakha, Pooja Gulati, Rakesh Bhatnagar
BACKGROUND: Bacillus anthracis (BA) is a major bioterrorism concern which has evolved complex regulatory mechanisms for its virulence factors. Secreted proteases play an imperative role in the pathogenesis of BA, however their regulation remains elusive. Two component systems (TCS) are often employed by bacteria to sense and adapt to the environmental perturbations. In several pathogens, TCS are commonly associated with the regulation of virulence factors including proteases. The genome of BA encodes 41 TCS pairs, however, the role of any TCS in regulation of its proteases is not known...
June 6, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28600207/conformational-behavior-of-alpha-2-macroglobulin-aggregation-and-inhibition-induced-by-tfe
#12
Ahmed Abdur Rehman, Masihuz Zaman, Mohammad Khalid Zia, Haseeb Ahsan, Rizwan Hasan Khan, Fahim Halim Khan
Alpha-2-macroglobulin (α2M), a pan-proteinase inhibitor, inhibits a variety of endogenous and exogenous proteinases and constitutes an important part of body's innate defense system. In the present study, we explored how trifluoroethanol (TFE) may modulate the structure, antiproteinase activity and aggregation of α2M. TFE was sequentially added over a range of 0-20% (v/v) and the effects induced were studied by activity assay, intrinsic fluorescence, ANS fluorescence, circular dichroism, turbidity assay, Rayleigh scattering measurement and ThT fluorescence measurement...
June 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28591754/changes-in-sleep-architecture-under-sustained-pain-in-adult-male-rats-subjected-to-neonatal-short-lasting-local-inflammatory-insult
#13
Cheryl C H Yang, Shiang-Suo Huang, Chun-Ting Lai, Terry B J Kuo, Ya-Chun Chu
Neonatal, short-lasting, local, nociceptive insult by carrageenan can cause long-term alterations in somatosensory and neurohumoral systems. We previously revealed hyporesponsiveness of the autonomic nervous system (ANS) after painful stimulation of adult rats in a neonatal carrageenan-induced pain model. Sleep disturbance has been highly correlated with pain and ANS activity. In the present study, adult rats that had received an intraplantar injection of carrageenan on postnatal day 1 were investigated to determine if there were alterations in their sleep architecture upon the stimulation of pain...
June 8, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28591590/salt-regulated-reversible-fibrillation-of-mycobacterium-tuberculosis-isocitrate-lyase-concurrent-restoration-of-structure-and-activity
#14
Harish Shukla, Ranjeet Kumar, Amit Sonkar, Kalyan Mitra, Md Sohail Akhtar, Timir Tripathi
Protein fibrillation is associated with a number of neurodegenerative diseases. Nevertheless, several proteins not related to disease can also form fibrils in vitro under specific conditions. In the present study, we demonstrate the reversible fibrillation of a globular protein that is modulated by salt under physiological pH. Mycobacterium tuberculosis Isocitrate lyase (MtbICL) is a crucial enzyme involved in the glyoxylate shunt and a potential drug target against M. tuberculosis infection. Under physiological pH, the enzyme self-assembles into a fibrillar structure in the absence of salt in vitro...
June 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28587966/bio-composites-based-on-polylactic-acid-and-argan-nut-shell-production-and-properties
#15
Sana Ait Laaziz, Marya Raji, Elmokhtar Hilali, Hamid Essabir, Denis Rodrigue, Rachid Bouhfid, Abou El Kacem Qaiss
The aim of this work is to develop a new bio-composite based on polylactic acid (PLA) reinforced with argan nut shells (ANS). In this study, the effect of ANS chemical surface treatments on the morphological, mechanical, thermal, and rheological properties of PLA was investigated. In particular, a comparison between three chemical treatments (alkali, bleaching, and silane) is made for two filler concentrations (8 and 15% wt.). Scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, dynamic mechanical analysis, and tensile measurements were used to determine the morphology (particle distribution/dispersion/adhesion), thermal stability, mechanical behavior and rheological properties of the bio-composites compared with neat PLA...
June 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28585232/in-vitro-in-silico-based-analysis-of-the-dose-dependent-in-vivo-estrogenicity-of-the-soy-phytoestrogen-genistein-in-humans
#16
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens
BACKGROUND AND PURPOSE: In vivo estrogenicity of genistein and its glycoside genistin is still under debate. The present study aimed to develop a physiologically based kinetic (PBK) model that provides insight in dose-dependent plasma concentrations of genistein aglycone and its metabolites and enables prediction of in vivo estrogenic effective dose levels of genistein and genistin in humans. EXPERIMENTAL APPROACH: A PBK model for genistein and genistin in humans was developed based on in vitro metabolic parameters...
June 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28579207/peripheral-nerve-involvement-in-fabry-s-disease-which-investigations-a-case-series-and-review-of-the-literature
#17
J Franques, P Sahuc, B Dussol, G Penaranda, L Swiader, R Froissart, S Attarian, C Stavris, L Chiche, J Pouget
BACKGROUND: Peripheral nerve system (PNS) involvement is common in Fabry's disease (FD), predominantly affecting the small nerve fibers that are difficult to investigate with conventional electrophysiological methods. PATIENTS AND METHODS: Eighteen patients followed for Fabry's disease underwent a prospective series of electroneurophysiological explorations, including a study of the cardiac parasympathetic autonomic nervous system (ANS) and electrochemical skin conductance (ESC) tests...
June 1, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28569421/autonomic-nervous-system-modulation-and-clinical-outcome-after-pulmonary-vein-isolation-using-the-second-generation-cryoballoon
#18
Shinsuke Miyazaki, Hiroaki Nakamura, Hiroshi Taniguchi, Hitoshi Hachiya, Takatsugu Kajiyama, Tomonori Watanabe, Miyako Igarashi, Sadamitsu Ichijo, Kenzo Hirao, Yoshito Iesaka
BACKGROUND: The intrinsic cardiac autonomic nervous system (ANS) plays a significant role in atrial fibrillation (AF) mechanisms. This study evaluated the incidence and impact of intraprocedural vagal reactions and ANS modulation by pulmonary vein isolation (PVI) using second-generation cryoballoons on outcomes. METHODS: One hundred three paroxysmal AF patients underwent PVI with one 28-mm second-generation balloon. The median follow-up was 15.0 (12.0-18.0) months...
June 1, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28562838/residential-substance-abuse-treatment-for-urban-american-indians-and-alaska-natives-part-ii-costs
#19
Bentson H McFarland, Dale Walker, Patricia Silk-Walker
The present study examined costs of two residential substance abuse treatment programs designed for urban American Indians and Alaska Natives (AI/ANs). Costs for one agency were well within national norms, while costs at the other program were less than expected from nationwide data. Economies of scale accounted for much of the difference between observed and expected costs. Culturally specific residential substance abuse treatment services can be provided to urban AI/ANs within budgets typically found at mainstream programs...
2017: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/28562837/residential-substance-abuse-treatment-for-urban-american-indians-and-alaska-natives-part-i-services-and-staff
#20
Bentson H McFarland, Dale Walker, Patricia Silk-Walker
Although residential substance abuse treatment is utilized extensively by urban American Indians and Alaska Natives (AI/ANs), there are few detailed descriptions of this care. This study delineated services provided by and interviewed staff working at residential programs designed for chemically dependent urban AI/ANs. Study agencies were compared to national data from residential programs serving general population clients. Study agencies delivered arrays of services substantially broader than those provided by general population programs...
2017: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
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