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https://www.readbyqxmd.com/read/28432085/acute-myeloid-leukaemia-in-a-case-with-tatton-brown-rahman-syndrome-the-peculiar-dnmt3a-r882-mutation
#1
Iris H I M Hollink, Ans M W van den Ouweland, H Berna Beverloo, Susan T C J M Arentsen-Peters, C Michel Zwaan, Anja Wagner
BACKGROUND: Recently a novel syndromic form of overgrowth with intellectual disability and distinct facial features was identified caused by constitutional mutations in the epigenetic regulator DNA-methyltransferase 3A (DNMT3A), referred to as Tatton-Brown-Rahman syndrome (TBRS). Somatically acquired mutations in DNMT3A occur in haematological malignancies and are frequently present in acute myeloid leukaemia (AML) affecting in more than 50% the arginine residue at position 882 (R882)...
April 21, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28427618/effects-of-high-intensity-unltrasound-on-structural-and-physicochemical-properties-of-myosin-from-silver-carp
#2
Ru Liu, Qing Liu, Shanbai Xiong, Yicheng Fu, Liang Chen
Myosin from silver carp was sonicated with varying power output (100, 150, 200 and 250W) for 3, 6, 9, and 12min. The changes in the structure and physicochemical properties of myosin were evaluated by dynamic light scattering, SDS-PAGE and some physicochemical indexes. The ultrasound treatments induced a significant conversion of myosin aggregates to smaller ones with a more uniform distribution, and obvious enhancement in solubility. The structure of myosin was also notably changed by sonication, with a decrease in Ca(2+)-ATPase activity and SH content, and an increase in surface hydrophobicity...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28424927/development-of-new-extra-glandular-manifestations-or-associated-auto-immune-diseases-after-establishing-the-diagnosis-of-primary-sj%C3%A3-gren-s-syndrome-a-long-term-study-of-the-antonius-nieuwegein-sj%C3%A3-gren-ans-cohort
#3
E J Ter Borg, J C Kelder
To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015...
April 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28414110/rifampicin-as-a-novel-tyrosinase-inhibitor-inhibitory-activity-and-mechanism
#4
Wei-Ming Chai, Mei-Zhen Lin, Fang-Jun Song, Ying-Xia Wang, Kai-Li Xu, Jing-Xin Huang, Jian-Ping Fu, Yi-Yuan Peng
In this study, the inhibitory effect and mechanism of rifampicin on the activity of tyrosinase were investigated for developing a novel tyrosinase inhibitor. It was found to have a significant inhibition on the activity of tyrosinase (IC50=90±0.6μM). From the kinetics analysis, it was proved to be a reversible and noncompetitive type inhibitor of the enzyme with the KI value of 94±3.5μM. The results obtained from intrinsic fluorescence quenching indicated that rifampicin could interact with tyrosinase. In particular, the drastic decrease of fluorescence intensity was due to the formation of a rifampicin-enzyme complex in a static procedure which was mainly driven by hydrophobic forces and hydrogen bonding...
April 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28411199/impact-of-fabp1-scp-2-scp-x-gene-ablation-tko-on-hepatic-phytol-metabolism-in-mice
#5
Stephen M Storey, Huan Huang, Avery L McIntosh, Gregory G Martin, Ann B Kier, Friedhelm Schroeder
Studies in vitro have suggested that both sterol carrier protein-2/sterol carrier protein-x (Scp-2/Scp-x) and liver fatty acid binding protein (Fabp1) gene products facilitate hepatic uptake and metabolism of lipotoxic dietary phytol. However, interpretation of physiological function in mice singly gene ablated in the Scp-2/Scp-x has been complicated by concomitant upregulation of FABP1. The work presented herein provides several novel insights: i) An ANS displacement assay showed that neither SCP-2 nor L-FABP bound phytol, but both had high affinity for its metabolite, phytanic acid; ii) GC/MS studies with phytol-fed wild-type (WT) and Fabp1/Scp-2/SCP-x gene ablated (TKO) mice showed that TKO exacerbated hepatic accumulation of phytol metabolites in vivo in females and less so in males...
April 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28403478/non-animal-approaches-for-toxicokinetics-in-risk-evaluations-of-food-chemicals
#6
Ans Punt, Ad A C M Peijnenburg, Ron L A P Hoogenboom, Hans Bouwmeester
The objective of the present work was to review the availability and predictive value of non-animal toxicokinetic approaches and to evaluate their current use in European risk evaluations of food contaminants, additives and food contact materials, as well as pesticides and medicines. Results revealed little use of quantitative animal or human kinetic data in risk evaluations of food chemicals, compared with pesticides and medicines. Risk evaluations of medicines provided sufficient in vivo kinetic data from different species to evaluate the predictive value of animal kinetic data for humans...
April 12, 2017: ALTEX
https://www.readbyqxmd.com/read/28399705/biophysical-insight-reveals-tannic-acid-as-amyloid-inducer-and-conformation-transformer-from-amorphous-to-amyloid-aggregates-in-concanavalin-a-cona
#7
Mohsin Vahid Khan, Mohd Ishtikhar, Mohammad Khursheed Siddiqui, Masihuz Zaman, Tajalli Ilm Chandel, Nabeela Majid, Mohd Rehan Ajmal, Ali Saber Abdelhameed, Yasser E Shahein, Rizwan Hasan Khan
The aggregation phenomenon (amyloid and amorphous) is associated with several pathological complications in human, such as Alzheimer's, Parkinson's, Huntington, Cataract diseases and Diabetes mellitus type 2. In the present study we are offering evidence and breaking the general belief with regard to the polyphenols action as protein aggregate inhibitors. Herein we confirm that tannic acid (TA) is not only an amyloid inducer, but also it switches one type of conformation, ultimately morphology, into another...
April 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28396269/serotonin-abrogates-dopamine-induced-aggregation-of-cytochrome-c
#8
Mohammad Furkan, Asim Rizvi, Md Tauqir Alam, Masihuz Zaman, Rizwan Hasan Khan, Aabgeena Naeem
Importance of cytochrome c arises from its involvement in apoptosis, sequence homology and conservedness during molecular evolution. The effect of dopamine gives the clue about the conformational changes taking place in cytochrome c, resulting in aggregation. Dopamine at 25μM concentration for 30hours resulted in cytochrome c aggregation as evident by increase in ANS, ThT binding, structural transition from α helix to β sheet and shift in congo red assay. Interestingly serotonin at 25μM concentration incubated for 60hours abrogates the aggregatory effect on cytochrome c...
April 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28395142/tax-avoidance-and-evasion-cigarette-purchases-from-indian-reservations-among-us-adult-smokers-2010-2011
#9
Xu Wang, Xin Xu, Michael A Tynan, Robert B Gerzoff, Ralph S Caraballo, Gabbi R Promoff
Excise taxes are the primary public health strategy used to increase the price of cigarettes in the United States. Rather than quitting or reducing consumption of cigarettes, some price-sensitive smokers may avoid state and local excise taxes by purchasing cigarettes from Indian reservations. The objectives of this study were to (1) provide the most recent state-specific prevalence of purchases made on Indian reservations by non-American Indians/Alaska Natives (non-AI/ANs) and (2) assess the impact of these purchases on state tax revenues...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28392518/development-of-tetrahydrofuran-water-optical-waveguide-and-its-application-to-the-observation-of-extraction-behavior-of-1-anilino-8-naphtalene-sulfonate-at-the-tetrahydrofuran-water-interface
#10
Hiromi Takiguchi, Soto Asanuma, Junya Kamiyama, Hiroyasu Murata, Yuki Hasegawa, Satoshi Yoshizawa, Hiroki Hotta, Tamao Odake, Tomonari Umemura, Kiichi Sato, Kin-Ichi Tsunoda
A stable two-phase sheath flow using tetrahydrofuran (THF) for an inner flow and water for an outer flow was formed in a glass capillary, and worked as a stable liquid-core/liquid-cladding optical waveguide (THF/water LLW). Although THF and water were miscible with any ratio, the length of the stable THF/water LLW at 0.9 - 2.1 cm s(-1) reached at least 150 mm. The THF/water LLW was applied to the observation of extraction behavior of solvatochromic fluorescence dye, 1-anilino-8-naphtalene sulfonate (ANS), through the THF/water interface...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28392310/the-role-of-the-autonomic-nervous-system-in-arrhythmias-and-sudden-cardiac-death
#11
REVIEW
Sonia Franciosi, Frances K G Perry, Thomas M Roston, Kathryn R Armstrong, Victoria E Claydon, Shubhayan Sanatani
The autonomic nervous system (ANS) is complex and plays an important role in cardiac arrhythmia pathogenesis. A deeper understanding of the anatomy and development of the ANS has shed light on its involvement in cardiac arrhythmias. Alterations in levels of Sema-3a and NGF, both growth factors involved in innervation patterning during development of the ANS, leads to cardiac arrhythmias. Dysregulation of the ANS, including polymorphisms in genes involved in ANS development, have been implicated in sudden infant death syndrome...
March 31, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28389403/how-the-presence-of-a-small-molecule-affects-the-complex-coacervation-between-lactoferrin-and-%C3%AE-lactoglobulin
#12
Guilherme M Tavares, Thomas Croguennec, Pascaline Hamon, Antônio F Carvalho, Saïd Bouhallab
Heteroprotein complex coacervation corresponds to the formation of two liquid phases in equilibrium induced by the interaction of two oppositely charged proteins. The more concentrated phase known as coacervate phase, has attracted interest from several fields of science due to its potential applications for example for encapsulation and delivery of bioactives. Prior such application, it is necessary to understand how the presence of small ligands affects the complex coacervation. In this work, we report on the interaction of small ligand with individual proteins β-lactoglobulin (β-LG) and lactoferrin (LF) and consequences on their complex coacervation...
April 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28387711/descriptive-analysis-of-lap1-distribution-and-that-of-associated-proteins-throughout-spermatogenesis
#13
Joana B Serrano, Filipa Martins, João C Sousa, Cátia D Pereira, Ans M M van Pelt, Sandra Rebelo, Odete A B da Cruz E Silva
Spermatogenesis comprises highly complex differentiation processes. Nuclear envelope (NE) proteins have been associated with these processes, including lamins, lamina-associated polypeptide (LAP) 2 and the lamin B-receptor. LAP1 is an important NE protein whose function has not been fully elucidated, but several binding partners allow predicting putative LAP1 functions. To date, LAP1 had not been associated with spermatogenesis. In this study, LAP1 expression and cellular/subcellular localization during spermatogenesis in human and mouse testes is established for the first time...
April 7, 2017: Membranes
https://www.readbyqxmd.com/read/28384496/approximate-number-sense-correlates-with-math-performance-in-gifted-adolescents
#14
Jinjing Jenny Wang, Justin Halberda, Lisa Feigenson
Nonhuman animals, human infants, and human adults all share an Approximate Number System (ANS) that allows them to imprecisely represent number without counting. Among humans, people differ in the precision of their ANS representations, and these individual differences have been shown to correlate with symbolic mathematics performance in both children and adults. For example, children with specific math impairment (dyscalculia) have notably poor ANS precision. However, it remains unknown whether ANS precision contributes to individual differences only in populations of people with lower or average mathematical abilities, or whether this link also is present in people who excel in math...
April 3, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28384191/differences-in-arithmetic-performance-between-chinese-and-german-adults-are-accompanied-by-differences-in-processing-of-non-symbolic-numerical-magnitude
#15
Jan Lonnemann, Su Li, Pei Zhao, Peng Li, Janosch Linkersdörfer, Sven Lindberg, Marcus Hasselhorn, Song Yan
Human beings are assumed to possess an approximate number system (ANS) dedicated to extracting and representing approximate numerical magnitude information. The ANS is assumed to be fundamental to arithmetic learning and has been shown to be associated with arithmetic performance. It is, however, still a matter of debate whether better arithmetic skills are reflected in the ANS. To address this issue, Chinese and German adults were compared regarding their performance in simple arithmetic tasks and in a non-symbolic numerical magnitude comparison task...
2017: PloS One
https://www.readbyqxmd.com/read/28383536/variation-in-quality-report-viewing-by-providers-and-correlation-with-nicu-quality-metrics
#16
N Wahid, M V Bennett, J B Gould, J Profit, B Danielsen, H C Lee
BACKGROUND: To examine variation in quality report viewing and assess correlation between provider report viewing and neonatal intensive care unit (NICU) quality. METHODS: Variation in report viewing sessions for 129 California Perinatal Quality Care Collaborative NICUs was examined. NICUs were stratified into tertiles based on their antenatal steroid (ANS) use and hospital-acquired infection (HAI) rates to compare report viewing session counts. RESULTS: The number of report viewing sessions initiated by providers varied widely over a 2-year period (median=11; mean=25...
April 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28376495/postural-orthostatic-tachycardia-predicts-early-conversion-to-multiple-sclerosis-after-clinically-isolated-syndrome
#17
Mario Habek, Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Barbara Barun, Ivan Adamec
BACKGROUND/AIMS: There have been suggestions that interactions exist between the autonomic nervous system (ANS) and the immune system functions in multiple sclerosis (MS). We aimed to evaluate the ANS dysfunction, more specifically postural orthostatic tachycardia syndrome (POTS), as a possible predictor of conversion to MS in patients with clinically isolated syndrome (CIS). METHODS: In this observational, prospective, longitudinal study, 84 patients were enrolled (56 females, mean age 32...
April 5, 2017: European Neurology
https://www.readbyqxmd.com/read/28372177/hydrophilic-interaction-chromatography-and-evaporative-light-scattering-detection-for-the-determination-of-polar-analytes-in-belgian-endive
#18
Carlo Annaratone, Ans De Roeck, Maarten L A T M Hertog, Bart M Nicolaï
Belgian endive (Cichorium intybus L. var. foliosum Hegi), a popular produce in northern Europe, has been thoroughly studied in regard to its bitter sesquiterpene lactones content. Much less is known about on its sweetness and crunchiness, which are typically linked to the content of polar compounds such as sugars, organic acids and salts. Through HILIC-HPLC-MS, it was shown that simple sugars, amino acids, and potassium chloride are abundant in Belgian endive extracts. Subsequently, a HILIC-HPLC-ELSD method for the analysis of such compounds with run times below six minutes was developed...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28371560/differential-scanning-calorimetry-and-fluorimetry-measurements-of-monoclonal-antibodies-and-reference-proteins-effect-of-scanning-rate-and-dye-selection
#19
Brian E Lang, Kenneth D Cole
Differential scanning calorimetry (DSC) and differential scanning fluorimetry (DSF) were used to measure the transition temperatures of four proteins: RNase A, invertase, rituximab, and the NISTmAb (NIST Reference Material, RM 8671). The proteins were combined with several different fluorescent dyes for the DSF measurements. This study compares the results of DSC and DSF measurements of transition temperatures with different types of proteins, dye combinations, and thermal scan rates. As protein unfolding is often influenced by kinetic effects, we measured the transition temperatures of the proteins using DSC over a range of temperature scan rates and compared them to the data obtained from DSF over comparable temperature scan rates...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28346857/the-influence-of-epicardial-fat-and-nonalcoholic-fatty-liver-disease-on-heart-rate-recovery-in-metabolic-syndrome
#20
Kyoung Im Cho, Eun Ah Jo, Sang Hoon Cho, Bo Hyun Kim
BACKGROUND: Epicardial adipose tissues reflecting visceral fat accumulations of the heart are associated with metabolic syndrome (MetS) and can be a predictor of other cardiometabolic diseases. It can adversely influence autonomic nervous system (ANS) of heart. Heart rate recovery (HRR) is an easy method for measuring ANS dysfunction. The purpose of this study was to determine whether epicardial fat thickness (EFT) and nonalcoholic fatty liver disease (NAFLD) are related to HRR in patients with MetS...
March 27, 2017: Metabolic Syndrome and related Disorders
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