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https://www.readbyqxmd.com/read/27788268/a-sixth-modality-of-infectious-disease-contagious-cancer-from-devils-to-clams-and-beyond
#1
Michael J Metzger, Stephen P Goff
No abstract text is available yet for this article.
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27751970/varicella-zoster-virus-infections-in-pediatric-malignancy-patients-a-7-year-analysis
#2
Mine Düzgöl, Gülcihan Özek, Nuri Bayram, Yeşim Oymak, Ahu Kara, Bengü Demirağ, Tuba Hilkay Karapınar, Yılmaz Ay, Canan Vergin, İlker Devrim
Primary Varicella Zoster Virus infection is a benign self-limited disease. In this study, we aimed to review our experience with focusing on the outcome and treatment of the varicella zoster virus (VZV) infection in pediatric malignancy patients. During the study period; a total of 41 patients with pediatric malignancy had been hospitalized with the diagnosis of VZV infection. All the patients were treated with intravenous acyclovir for a median of 7 days (ranging from 5 to 21 days). The calculated attributable delay of chemotherapy due to VZV infections was 8 days (ranging from 2 to 60 days)...
October 18, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27699526/hpv-in-head-and-neck-cancer-30%C3%A2-years-of-history
#3
Stina Syrjänen, Jaana Rautava, Kari Syrjänen
The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Parsons and Kidd described the natural history of oral PV infections in rabbits already in 1942, but these findings were corroborated in humans only recently...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27501861/a-la-p%C3%A3%C2%AAche-aux-moules
#4
Bernard Perbal
In a recent manuscript, Goff and collaborators (Metzger et al. 2016) reported data arguing for the spread of contagious cancer cells among different species of shellfish. Although horizontal transmission of cancer cells has been observed in a few cases in higher organisms, it appears to be rather frequent among molluscs. Recent evidence supports the concept of inter-species horizontal infectious transmission of cancer cells both in molluscs but also in mammals, including humans.
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27417118/transmissible-cancers-in-an-evolutionary-context
#5
REVIEW
Beata Ujvari, Anthony T Papenfuss, Katherine Belov
Cancer is an evolutionary and ecological process in which complex interactions between tumour cells and their environment share many similarities with organismal evolution. Tumour cells with highest adaptive potential have a selective advantage over less fit cells. Naturally occurring transmissible cancers provide an ideal model system for investigating the evolutionary arms race between cancer cells and their surrounding micro-environment and macro-environment. However, the evolutionary landscapes in which contagious cancers reside have not been subjected to comprehensive investigation...
July 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27357231/the-lxr-ligand-gw3965-inhibits-newcastle-disease-virus-infection-by-affecting-cholesterol-homeostasis
#6
Xiang-Xiang Sheng, Ying-Jie Sun, Yuan Zhan, Yu-Rong Qu, Hua-Xia Wang, Miao Luo, Ying Liao, Xu-Sheng Qiu, Chan Ding, Hong-Jie Fan, Xiang Mao
Newcastle disease (ND) is a contagious disease that affects most species of birds. Its causative pathogen, Newcastle disease virus (NDV), also exhibits considerable oncolytic activity against mammalian cancers. A better understanding of the pathogenesis of NDV will help us design efficient vaccines and novel anticancer strategies. GW3965, a widely used synthetic ligand of liver X receptor (LXR), induces the expression of LXRs and its downstream genes, including ATP-binding cassette transporter A1 (ABCA1). ABCA1 regulates cellular cholesterol homeostasis...
September 2016: Archives of Virology
https://www.readbyqxmd.com/read/27353282/ovarian-cancer-patients-and-their-family-members-perspectives-on-novel-vaccine-and-virotherapy-trials
#7
Carmen Radecki Breitkopf, Jennifer L Ridgeway, Gladys B Asiedu, Katherine Carroll, Meaghan Tenney, Aminah Jatoi
BACKGROUND/AIMS: Some of the most promising avenues of cancer clinical investigation center on immunotherapeutic approaches. These approaches have provided notable gains in cancer therapeutics with recent Food and Drug Administration approvals of agents of this class in several types of cancers, although gains for ovarian cancer lag behind. This study examined perceptions of therapeutic trials including immunotherapy and virotherapy among ovarian cancer patients and their family members...
December 2016: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/27218794/infectious-disease-report-bordetella-pertussis-infection-in-patients-with-cancer
#8
Abraham Yacoub, Sowmya Nanjappa, Tyler Janz, John N Greene
We illustrate 2 cases of pneumonia associated with Bordetella pertussis infection in 72-year-old and 61-year-old patients with cancer receiving myelosuppressive therapy after hematopoietic stem cell transplantation. Bacterial infections are a significant cause of morbidity and mortality in patients with cancer, and those receiving hematopoietic stem cell transplant, solid organ transplant, or myelosuppressive therapy are at increased risk. The infection was detected and the 2 patients had good outcomes following azithromycin treatment...
April 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27154541/jaagsiekte-sheep-retrovirus-can-reach-peyer-s-patches-and-mesenteric-lymph-nodes-of-lambs-nursed-by-infected-mothers
#9
M Borobia, M De Las Heras, J J Ramos, L M Ferrer, D Lacasta, A De Martino, A Fernández, A Loste, D Marteles, A Ortín
Ovine pulmonary adenocarcinoma (OPA) is a contagious lung cancer of sheep caused by jaagsiekte sheep retrovirus (JSRV). It is generally accepted that transmission by the respiratory route occurs under natural conditions. However recent studies strongly indicate that JSRV can also be transmitted to lambs perinatally via colostrum and milk (C/M). The aim of this work was to confirm that C/M can transmit JSRV infection to lambs under natural conditions and investigate the initial events associated with this transmission route...
May 6, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/26935418/chicken-gga-mir-103-3p-targets-ccne1-and-tfdp2-and-inhibits-mdcc-msb1-cell-migration
#10
Bo Han, Ling Lian, Xin Li, Chunfang Zhao, Lujiang Qu, Changjun Liu, Jiuzhou Song, Ning Yang
Marek's disease (MD) is a highly contagious viral neoplastic disease caused by Marek's disease virus (MDV), which can lead to huge economic losses in the poultry industry. Recently, microRNAs (miRNAs) have been found in various cancers and tumors. In recent years, 994 mature miRNAs have been identified through deep sequencing in chickens, but only a few miRNAs have been investigated further in terms of their function. Previously, gga-miR-103-3p was found downregulated in MDV-infected samples by using Solexa deep sequencing...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/26689946/the-tasmanian-devil-microbiome-implications-for-conservation-and-management
#11
Yuanyuan Cheng, Samantha Fox, David Pemberton, Carolyn Hogg, Anthony T Papenfuss, Katherine Belov
BACKGROUND: The Tasmanian devil, the world's largest carnivorous marsupial, is at risk of extinction due to devil facial tumour disease (DFTD), a fatal contagious cancer. The Save the Tasmanian Devil Program has established an insurance population, which currently holds over 600 devils in captive facilities across Australia. Microbes are known to play a crucial role in the health and well-being of humans and other animals, and increasing evidence suggests that changes in the microbiota can influence various aspects of host physiology and development...
2015: Microbiome
https://www.readbyqxmd.com/read/26611278/breast-cancer-knowledge-among-male-high-school-students-in-saudi-arabia
#12
Samia Al-Amoudi, Moaiad Tariq Abdul-Aziz AlHomied, Nasser Youssef Nasser AlSayegh, Osama Naseem Ismail Radi, Mohammed Majed Suliman Zagzoog, Omar Faisal Mubarak Aloufi, Abdullah Abdulkarim Ali Al-Harbi, Safwan Tayeb, Mohammed Hassanien, Mahmoud Al-Ahwal, Basem Eldeek, Steve Harakeh
Breast cancer (BC) accounts for 24 % of all women cancer cases diagnosed in Saudi Arabia each year. Awareness is extremely important in combating this disease. This study was undertaken to assess male high school students' response to BC. This cross-sectional survey was performed on male high school students across schools in Jeddah. A questionnaire gathered data on respondent demographics, beliefs about BC, BC risk factors, early screening methods, and role of men in BC. Statistical analysis was done using SPSS 20...
December 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/26467759/development-of-a-snp-based-assay-for-measuring-genetic-diversity-in-the-tasmanian-devil-insurance-population
#13
Belinda Wright, Katrina Morris, Catherine E Grueber, Cali E Willet, Rebecca Gooley, Carolyn J Hogg, Denis O'Meally, Rodrigo Hamede, Menna Jones, Claire Wade, Katherine Belov
BACKGROUND: The Tasmanian devil (Sarcophilus harrisii) has undergone a recent, drastic population decline due to the highly contagious devil facial tumor disease. The tumor is one of only two naturally occurring transmissible cancers and is almost inevitably fatal. In 2006 a disease-free insurance population was established to ensure that the Tasmanian devil is protected from extinction. The insurance program is dependent upon preserving as much wild genetic diversity as possible to maximize the success of subsequent reintroductions to the wild...
2015: BMC Genomics
https://www.readbyqxmd.com/read/26365162/snps-in-candidate-genes-mx-dynamin-like-gtpase-and-chemokine-c-c-motif-receptor-5-are-associated-with-ovine-pulmonary-adenocarcinoma-progression-in-latxa-sheep
#14
A Larruskain, A Esparza-Baquer, E Minguijón, R A Juste, B M Jugo
Ovine pulmonary adenocarcinoma (OPA) is a contagious lung cancer in sheep caused by Jaagsiekte sheep retrovirus (JSRV). OPA is present in many sheep-rearing countries causing economic and welfare issues, as currently no efficient vaccines or treatments are available. Breed differences suggest a host genetic component may influence the pathogenesis of OPA, but so far few genes have been identified. In this work, a genetic association study was carried out in Latxa dairy sheep which were classified as cases/controls based on the presence/absence of OPA lung tumours...
December 2015: Animal Genetics
https://www.readbyqxmd.com/read/26300316/characterization-of-antibody-v-segment-diversity-in-the-tasmanian-devil-sarcophilus-harrisii
#15
Beata Ujvari, Katherine Belov
The Tasmanian devil (Sarcophilus harrisii) immune system has recently been under scrutiny because of the emergence of a contagious cancer, which has decimated devil numbers. Here we provide a comprehensive description of the Tasmanian devil immunoglobulin variable regions. We show that heavy chain variable (VH) and light chain variable (VL) repertoires are similar to those described in other marsupial taxa: VL diversity is high, but VH diversity is restricted and belongs only to clan III. As in other mammals, one VH and one Vλ germline family and multiple incomplete Vκ germline sequences were identified in the genome...
October 15, 2015: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/26251032/molecular-characterization-of-an-apoptotic-strain-of-newcastle-disease-virus-isolated-from-an-outbreak-in-india
#16
U Kumar, S Kumar
Newcastle disease (ND) is a highly contagious disease of poultry. The ND virus (NDV) encodes an error-prone RNA-dependent RNA polymerase which can cause high mutation rate leading to the emergence of its new antigenic variants. Antigenic difference of NDV strains may result in massive outbreak in vaccinated and unvaccinated poultry flocks around the globe. Apart from its pathogenic potential NDV has been explored as an oncolytic agent for a broad range of human cancers. In the present study, we isolated a novel NDV strain from an outbreak in chicken flock from the eastern part of India...
August 2015: Cancer Gene Therapy
https://www.readbyqxmd.com/read/26027792/genomic-insights-into-a-contagious-cancer-in-tasmanian-devils
#17
REVIEW
Catherine E Grueber, Emma Peel, Rebecca Gooley, Katherine Belov
The Tasmanian devil faces extinction due to a contagious cancer. Genetic and genomic technologies revealed that the disease arose in a Schwann cell of a female devil. Instead of dying with the original host, the tumour was passed from animal to animal, slipping under the radar of the immune system. Studying the genomes of the devil and the cancer has driven our understanding of this unique disease. From characterising immune genes and immune responses to studying tumour evolution, we have begun to uncover how a cancer can be 'caught' and are using genomic data to manage an insurance population of disease-free devils for the long-term survival of the species...
September 2015: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/25708088/evidence-for-induction-of-humoral-and-cytotoxic-immune-responses-against-devil-facial-tumor-disease-cells-in-tasmanian-devils-sarcophilus-harrisii-immunized-with-killed-cell-preparations
#18
A Kreiss, G K Brown, C Tovar, A B Lyons, G M Woods
Tasmanian devils (Sarcophilus harrisii) risk extinction from a contagious cancer, devil facial tumour disease (DFTD) in which the infectious agent is the tumor cell itself. Because devils are unable to produce an immune response against the tumor cells no devil has survived 'infection'. To promote an immune response we immunized healthy devils with killed DFTD tumor cells in the presence of adjuvants. Immune responses, including cytotoxicity and antibody production, were detected in five of the six devils. The incorporation of adjuvants that act via toll like receptors may provide additional signals to break 'immunological ignorance'...
June 12, 2015: Vaccine
https://www.readbyqxmd.com/read/25557811/bovine-genome-wide-association-study-for-genetic-elements-to-resist-the-infection-of-foot-and-mouth-disease-in-the-field
#19
Bo-Young Lee, Kwang-Nyeong Lee, Taeheon Lee, Jong-Hyeon Park, Su-Mi Kim, Hyang-Sim Lee, Dong-Su Chung, Hang-Sub Shim, Hak-Kyo Lee, Heebal Kim
Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle...
February 2015: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/25512152/cancer-burden-in-latin-america-and-the-caribbean
#20
REVIEW
Maria Paula Curado, Dyego Leandro Bezerra de Souza
BACKGROUND: In Latin America and the Caribbean, the epidemiological transition has been occurring in an unequal manner. Infectious-contagious diseases share space with the increase of chronic nontransmissible diseases, such as cancer, which already represents the second most common cause of death, after cardiovascular illnesses. OBJECTIVES: This study provides a global picture of the burden of cancer in Latin America and the Caribbean, as well as the challenges faced when controlling this disease in these regions...
September 2014: Annals of Global Health
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