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Contagious cancers

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https://www.readbyqxmd.com/read/29751531/computational-analysis-of-the-interaction-energies-between-amino-acid-residues-of-the-measles-virus-hemagglutinin-and-its-receptors
#1
Fengqi Xu, Shigenori Tanaka, Hirofumi Watanabe, Yasuhiro Shimane, Misako Iwasawa, Kazue Ohishi, Tadashi Maruyama
Measles virus (MV) causes an acute and highly devastating contagious disease in humans. Employing the crystal structures of three human receptors, signaling lymphocyte-activation molecule (SLAM), CD46, and Nectin-4, in complex with the measles virus hemagglutinin (MVH), we elucidated computationally the details of binding energies between the amino acid residues of MVH and those of the receptors with an ab initio fragment molecular orbital (FMO) method. The calculated inter-fragment interaction energies (IFIEs) revealed a number of significantly interacting amino acid residues of MVH that played essential roles in binding to the receptors...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29560169/comparison-of-the-serum-and-salivary-antibodies-to-detect-gastric-helicobacter-pylori-infection-in-kashan-iran
#2
Ahmad Piroozmand, Babak Soltani, Mohsen Razavizadeh, Amir Hasan Matini, Hamid Reza Gilasi, Abbas Nassaji Zavareh, Siamak Soltani
Background and aim: Helicobacter pylori ( H. pylori ) is an important and common contagious human pathogen which may cause peptic ulcer and also gastric cancer. The definite diagnosis of it is made through invasive tests. Recently, non-invasive tests including serologic tests of serum and saliva have been conducted for diagnosis of H. pylori infection. In this research, the diagnostic values of serum and salivary serology were compared together to use salivary anti- H. pylori test as an alternative method in the future...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29520077/mhc-diversity-and-female-age-underpin-reproductive-success-in-an-australian-icon-the-tasmanian-devil
#3
Tracey Russell, Simeon Lisovski, Mats Olsson, Gregory Brown, Rebecca Spindler, Amanda Lane, Tamara Keeley, Chris Hibbard, Carolyn J Hogg, Frédéric Thomas, Katherine Belov, Beata Ujvari, Thomas Madsen
Devil Facial Tumour Disease (DFTD), a highly contagious cancer, has decimated Tasmanian devil (Sarcophilus harrisii) numbers in the wild. To ensure its long-term survival, a captive breeding program was implemented but has not been as successful as envisaged at its launch in 2005. We therefore investigated the reproductive success of 65 captive devil pair combinations, of which 35 produced offspring (successful pairs) whereas the remaining 30 pairs, despite being observed mating, produced no offspring (unsuccessful pairs)...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319454/death-contagion-and-shame-the-potential-of-cancer-survivors-advocacy-in-zambia
#4
Britta Wigginton, Kim Farmer, Sharon Kapambwe, Lisa Fitzgerald, Marina M Reeves, Sheleigh P Lawler
Cancer has become a global health concern with marked differences in the incidence and mortality rates between developing and developed countries. Understanding the factors that shape uptake of preventative and screening services is the key. We use in-depth interviews with 13 Zambian urban-based female cancer survivors to explore the facilitators and barriers to screening, diagnosis and treatment, with a particular focus on cultural influences. We identified a central theme (i.e. a story told about cancer) in all of the interviews: 'cancer is a death sentence'...
January 10, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29135134/treating-the-incurables-cancer-asylums-in-18th-and-19th-century
#5
Marianna Karamanou, Theodora Psaltopoulou, Kostas Markatos, Georgios Karaoglanis, George Androutsos
For centuries several hypotheses were formulated on cancer's pathogenesis such as contagiousness, melancholy, heredity and sexuality. In the 18th and 19th century, despite the advent of medical thought and practice, cancer was considered an incurable and contagious disease. Hospitals were refusing to treat cancer patients while the social stigma which followed the disease made primordial the need for the establishment of special institutions. In our article we will present the cancer asylums which counterbalanced the prejudices of the time and contributed to the establishment of modern cancer hospitals...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29094085/awareness-and-perception-about-cancer-among-the-public-in-chennai-india
#6
Vidhubala Elangovan, Swaminathan Rajaraman, Barsha Basumalik, Dhivya Pandian
Purpose: Cancer-related stigma influences the way people perceive cancer, which renders cancer control-beginning with prevention and proceeding to palliation-a challenging task. This study aimed to assess the current levels of awareness and perceptions about cancer among people with various socioeconomic status and diverse backgrounds in the city of Chennai, India. Patients and Methods: The sample population (N = 2,981; 18 to 88 years of age) was stratified into four groups: patients (n = 510), caregivers (n = 494) consulting at the Cancer Institute (Women Indian Association), college students (n = 978), and general public (n = 999)...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28860661/long-intergenic-non-coding-rna-galmd3-in-chicken-marek-s-disease
#7
Bo Han, Yanghua He, Li Zhang, Yi Ding, Ling Lian, Chunfang Zhao, Jiuzhou Song, Ning Yang
Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences. Studies have revealed that aberrant expressions of lincRNAs are associated with various types of cancers and neurological disorders. Marek's disease (MD) is a highly contagious T-cell lymphoid neoplasia of chicken induced by Marek's disease virus (MDV). In this study, we first identified and validated linc-GALMD3 highly expressed in MDV-infected CD4+ T cells by RNA-Seq and qRT-PCR. By RNA-Seq analysis in MDCC-MSB1 cells after loss of function of linc-GALMD3 by shRNA, we found that linc-GALMD3 could positively cis-regulate its downstream gga-miR-223 gene expression...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28769911/vp2-of-infectious-bursal-disease-virus-induces-apoptosis-via-triggering-oral-cancer-overexpressed-1-oraov1-protein-degradation
#8
Yao Qin, Zhichao Xu, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive avian disease caused by IBD virus (IBDV). Cell apoptosis triggered by IBDV contributes to the dysfunction of immune system in host. VP2 of IBDV is known to induce cell death but the underlying mechanism remains unclear. Here we demonstrate that VP2 interacts with the oral cancer overexpressed 1 (ORAOV1), a potential oncoprotein. Infection by IBDV or ectopic expression of VP2 causes a reduction of cellular ORAOV1 and induction of apoptosis, so does knockdown of ORAOV1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28695294/the-role-of-mhc-genes-in-contagious-cancer-the-story-of-tasmanian-devils
#9
REVIEW
Alison Caldwell, Hannah V Siddle
The Tasmanian devil, a marsupial species endemic to the island of Tasmania, harbours two contagious cancers, Devil Facial Tumour 1 (DFT1) and Devil Facial Tumour 2 (DFT2). These cancers pass between individuals in the population via the direct transfer of tumour cells, resulting in the growth of large tumours around the face and neck of affected animals. While these cancers are rare, a contagious cancer also exists in dogs and five contagious cancers circulate in bivalves. The ability of tumour cells to emerge and transmit in mammals is surprising as these cells are an allograft and should be rejected due to incompatibility between Major Histocompatibility Complex (MHC) genes...
August 2017: Immunogenetics
https://www.readbyqxmd.com/read/28608726/stigma-and-work-discrimination-among-cancer-survivors-a-scoping-review-and-recommendations
#10
Mary Stergiou-Kita, Xueqing Qie, Hau Ki Yau, Sally Lindsay
BACKGROUND: Stigma and workplace discrimination can hinder employment opportunities for cancer survivors. PURPOSE: This study explored perceptions of stigma and workplace discrimination for cancer survivors to understand the impact on survivors' engagement in paid work and to identify strategies to address stigma and workplace discrimination. METHOD: Using Arksey and O'Malley's framework, we searched Medline, Embase, PsycINFO, Scopus, and CINAHL for evidence that intersected three concepts: cancer, stigma, and employment/workplace discrimination...
January 1, 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#11
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
June 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28500329/no-evidence-of-inbreeding-depression-in-a-tasmanian-devil-insurance-population-despite-significant-variation-in-inbreeding
#12
Rebecca Gooley, Carolyn J Hogg, Katherine Belov, Catherine E Grueber
Inbreeding depression occurs when inbred individuals experience reduced fitness as a result of reduced genome-wide heterozygosity. The Tasmanian devil faces extinction due to a contagious cancer, devil facial tumour disease (DFTD). An insurance metapopulation was established in 2006 to ensure the survival of the species and to be used as a source population for re-wilding and genetic rescue. The emergence of DFTD and the rapid decline of wild devil populations have rendered the species at risk of inbreeding depression...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300197/significant-decline-in-anticancer-immune-capacity-during-puberty-in-the-tasmanian-devil
#13
Yuanyuan Cheng, Kim Heasman, Sarah Peck, Emma Peel, Rebecca M Gooley, Anthony T Papenfuss, Carolyn J Hogg, Katherine Belov
Tasmanian devils (Sarcophilus harrisii) are at risk of extinction in the wild due to Devil Facial Tumour Disease (DFTD), a rare contagious cancer. The prevalence of DFTD differs by age class: higher disease prevalence is seen in adults (2-3 years) versus younger devils (<2 years). Here we propose that immunological changes during puberty may play a role in susceptibility to DFTD. We show that the second year of life is a key developmental period for Tasmanian devils, during which they undergo puberty and pronounced changes in the immune system...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250131/measles-virus-enters-breast-and-colon-cancer-cell-lines-through-a-pvrl4-mediated-macropinocytosis-pathway
#14
Sebastien Delpeut, Gary Sisson, Karen M Black, Christopher D Richardson
Measles virus (MeV) is a member of the family Paramixoviridae that causes a highly contagious respiratory disease but has emerged as a promising oncolytic platform. Previous studies of MeV entry focused on the identification of cellular receptors. However, the endocytic and trafficking pathways utilized during MeV entry remain poorly described. The contribution of each endocytic pathway has been examined in cells that express the MeV receptors SLAM (signaling lymphocyte-activating molecule) and PVRL4 (poliovirus receptor-like 4) (nectin-4)...
May 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28212650/skin-cancer-knowledge-and-attitudes-in-the-region-of-fez-morocco-a-cross-sectional-study
#15
Awatef Kelati, Hanane Baybay, Mariam Atassi, Samira Elfakir, Salim Gallouj, Mariame Meziane, Fatima Zahra Mernissi
BACKGROUND: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco. METHODS: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014)...
February 17, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28205368/cancer-as-a-contagious-disease
#16
REVIEW
H V Siddle
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism...
April 2017: HLA
https://www.readbyqxmd.com/read/28127390/weird-genotypes-don-t-discard-them-transmissible-cancer-could-be-an-explanation
#17
Florentine Riquet, Alexis Simon, Nicolas Bierne
Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. Parasitic cancers were thought to be rare exceptions, only reported in dogs (Murgia et al., Cell, 2006, 126, 477; Rebbeck et al., Evolution, 2009, 63, 2340), Tasmanian devils (Pearse and Swift, Nature, 2006, 439, 549; Pye et al...
February 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28107820/evidence-against-a-role-for-jaagsiekte-sheep-retrovirus-in-human-lung-cancer
#18
A Dusty Miller, Marcelo De Las Heras, Jingyou Yu, Fushun Zhang, Shan-Lu Liu, Andrew E Vaughan, Thomas L Vaughan, Raul Rosadio, Stefano Rocca, Giuseppe Palmieri, James J Goedert, Junya Fujimoto, Ignacio I Wistuba
BACKGROUND: Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retroviruses, the JSRV Env protein is also a potent oncoprotein and is responsible for lung cancer in animals. Of concern, Hyal2 is a functional receptor for JSRV in humans. RESULTS: We show here that JSRV is fully capable of infecting human cells, as measured by its reverse transcription and persistence in the DNA of cultured human cells...
January 20, 2017: Retrovirology
https://www.readbyqxmd.com/read/27788268/a-sixth-modality-of-infectious-disease-contagious-cancer-from-devils-to-clams-and-beyond
#19
REVIEW
Michael J Metzger, Stephen P Goff
No abstract text is available yet for this article.
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27751970/varicella-zoster-virus-infections-in-pediatric-malignancy-patients-a-seven-year-analysis
#20
Mine Düzgöl, Gülcihan Özek, Nuri Bayram, Yeşim Oymak, Ahu Kara, Bengü Demirağ, Tuba Hilkay Karapınar, Yılmaz Ay, Canan Vergin, İlker Devrim
Primary varicella-zoster virus (VZV) infection is a benign self-limited disease. In this study, we review our experience in focusing on the outcome and treatment of VZV infection in pediatric malignancy patients. During the study period, a total of 41 patients with pediatric malignancy had been hospitalized with the diagnosis of VZV infection. All the patients were treated with intravenous acyclovir for a median of 7 days (ranging from 5 to 21 days). The calculated attributable delay of chemotherapy due to VZV infections was 8 days (ranging from 2 to 60 days)...
December 1, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
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