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https://www.readbyqxmd.com/read/29044689/behead-and-live-long-or-the-tale-of-cathepsin-l
#1
Maria Karolin Streubel, Johannes Bischof, Richard Weiss, Jutta Duschl, Wolfgang Liedl, Herbert Wimmer, Michael Breitenbach, Manuela Weber, Florian Geltinger, Klaus Richter, Mark Rinnerthaler
In the last decades S. cerevisiae has proven to be one of the most valuable model organisms of aging research. Pathways as autophagy or the effect of substances like resveratrol and spermidine that prolong the replicative as well as chronological lifespan of cells have been described for the first time in S. cerevisiae. In this study we describe the establishment of an aging reporter that allows a reliable and relative quick screening of substances and genes that have an impact on the replicative lifespan. A cDNA library of the flatworm Dugesia tigrina that can be immortalized by beheading was screened using this aging reporter...
October 17, 2017: Yeast
https://www.readbyqxmd.com/read/29044167/impact-of-heavy-metal-lead-stress-on-polyamine-levels-in-halomonas-bvr-1-isolated-from-an-industry-effluent
#2
Manasi, Sridev Mohapatra, N Rajesh, Vidya Rajesh
In living systems, environmental stress due to biotic and abiotic factors triggers the production of myriad metabolites as a potential mechanism for combating stress. Among these metabolites are the small polycationic aliphatic amine molecules - polyamines, which are ubiquitous in all living organisms. In this work, we demonstrate a correlation between cellular concentration of three major polyamines (putrescine, spermidine and spermine) with lead exposure on bacteria for a period of 6-24 h. We report that indigenously isolated Halomonas sp...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043098/spermidine-is-protective-against-kidney-ischemia-and-reperfusion-injury-through-inhibiting-dna-nitration-and-parp1-activation
#3
Jinu Kim
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring polyamine, protects yeast cells against aging through the inhibition of oxidative stress and necrosis. In the present study, spermidine supplementation markedly attenuated histological damage and kidney dysfunction during IRI. In addition, exogenous spermidine potently inhibited poly(ADP-ribose) polymerase 1 (PARP1) activation and DNA nitrative/oxidative stress following IRI...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042616/reduced-nitric-oxide-levels-during-drought-stress-promote-drought-tolerance-in-barley-and-is-associated-with-elevated-polyamine-biosynthesis
#4
Gracia Montilla-Bascón, Diego Rubiales, Kim H Hebelstrup, Julien Mandon, Frans J M Harren, Simona M Cristescu, Luis A J Mur, Elena Prats
Nitric oxide (NO) is a key messenger in plant stress responses but its exact role in drought response remains unclear. To investigate the role of NO in drought response we employed transgenic barley plants (UHb) overexpressing the barley non-symbiotic hemoglobin gene HvHb1 that oxidizes NO to NO3(-). Reduced NO production under drought conditions in UHb plants was associated with increased drought tolerance. Since NO biosynthesis has been related to polyamine metabolism, we investigated whether the observed drought-related NO changes could involve polyamine pathway...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029392/spermine-and-spermidine-reversed-age-related-cardiac-deterioration-in-rats
#5
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian, Yajun Zhao
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28983692/roseomonas-aeriglobus-sp-nov-isolated-from-an-air-conditioning-system
#6
Yunho Lee, Che Ok Jeon
A novel pale pink-coloured, strictly aerobic, Gram-stain negative bacterial strain, designated strain KER25-12(T), was isolated from a laboratory air-conditioning system in South Korea. Cells were observed to be non-motile cocci showing positive catalase and oxidase reactions. Strain KER25-12(T) was found to grow at 10-30 °C (optimum, 25-30 °C), at pH 4.0-9.0 (optimum, pH 6.0-7.0) and in the presence of 0-2% (w/v) NaCl (optimum, 0%). Ubiquinone-10 and spermidine were detected as the sole respiratory quinone and the predominant polyamine, respectively...
October 5, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28981578/potassium-not-lepidimoide-is-the-principal-allelochemical-of-cress-seed-exudate-that-promotes-amaranth-hypocotyl-elongation
#7
Stephen C Fry
Background and Aims: Imbibed cress ( Lepidium sativum L.) seeds exude 'allelochemicals' that promote excessive hypocotyl elongation and inhibit root growth in neighbouring competitors, e.g. amaranth ( Amaranthus caudatus L.) seedlings. The major hypocotyl promoter has recently been shown not to be the previously suggested acidic disaccharide, lepidimoic acid (LMA), a fragment of the pectic polysaccharide domain rhamnogalacturonan-I. The nature of the hypocotyl promoter has now been re-assessed...
July 11, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28971766/ornithine-decarboxylase-inhibition-a-strategy-to-combat-various-diseases
#8
Priyanshu R Rai, Rakesh R Somani, Pooja S Kandpile
Ornithine decarboxylase is the first enzyme in the polyamine biosynthetic pathway. It is the rate-limiting enzyme which is included in the change of ornithine to putrescine which is the first polyamine. Polyamines (putrescine, spermidine, spermine) are natural and synthetic compounds which contains two or more amino group. Polyamines are highly implicated in cellular functions such as cell-growth & multiplication, DNA stabilization, gene transcription and translation, ion-channel activity, etc. Elevated levels of polyamines were found in highly proliferating tumour cells...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28965950/spermine-and-spermidine-act-as-chemical-chaperones-and-enhance-chaperone-like-and-membranolytic-activities-of-major-bovine-seminal-plasma-protein-pdc-109
#9
Bhanu Pratap Singh, Ishita Saha, Indrani Nandi, Musti J Swamy
The major bovine seminal plasma protein, PDC-109, binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids (cholesterol efflux), which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity (CLA) and protects target proteins against various kinds of stress. Here we show that the polyamines spermine (Spm) and spermidine (Spd), present in high concentration in the seminal plasma of various mammals, increase the ability of PDC-109 to perturb membrane structure as well as its CLA...
September 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28941402/copper-ii-ions-interactions-in-the-systems-with-triamines-and-atp-potentiometric-and-spectroscopic-studies
#10
S K Hoffmann, J Goslar, R Bregier-Jarzebowska, A Gasowska, A Zalewska, L Lomozik
The mode of interaction and thermodynamic stability of complexes formed in binary and ternary Cu(II)/ATP/triamines systems were studied using potentiometric and spectroscopic (NMR, EPR, UV-Vis) methods. It was found that in binary metal-free systems ATP/HxPA species are formed (PA: Spd=spermidine or 3,3-tri=1,7-diamino-4-azaheptane) where the phosphate groups from nucleotides are preferred negative centers and protonated amine groups of amines are positive centers of reaction. In the ternary systems Cu/ATP/Hx(PA) as well as Cu/(ATP)(PA) species are formed...
September 9, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28932114/spermidine-mediated-poly-lactic-co-glycolic-acid-nanoparticles-containing-fluorofenidone-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#11
Jing Tang, Jianming Li, Guo Li, Haitao Zhang, Ling Wang, Dai Li, Jinsong Ding
Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival. The advances made in deciphering this disease have led to the approval of different antifibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles (liposomes, nanoparticles [NPs], microspheres, nanopolymersomes, and nanoliposomes) modified with different functional groups have demonstrated improvement in lung-targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine (Spd)-modified poly(lactic-co-glycolic acid) (PLGA) NPs as carriers for fluorofenidone (AKF) to improve the antifibrotic efficacy of this drug in the lung...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28914418/spermidine-rescues-proximal-tubular-cells-from-oxidative-stress-and-necrosis-after-ischemic-acute-kidney-injury
#12
Jinu Kim
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring polyamine, protects yeast cells against aging through the inhibition of oxidative stress and necrosis. In the present study, spermidine supplementation markedly attenuated increases in plasma creatinine concentration and tubular injury score after IRI. In addition, exogenous spermidine potently inhibited oxidative stress, especially lipid peroxidation after IRI in kidneys and exposure to hydrogen peroxide in kidney proximal tubular cells, suppressing plasma membrane disruption and necrosis...
September 15, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28888960/complete-genome-sequence-of-endophyte-bacillus-flexus-klbmp-4941-reveals-its-plant-growth-promotion-mechanism-and-genetic-basis-for-salt-tolerance
#13
Tian-Tian Wang, Peng Ding, Pan Chen, Ke Xing, Juan-Luan Bai, Wen Wan, Ji-Hong Jiang, Sheng Qin
Bacillus flexus KLBMP 4941 is a halotolerant endophyte isolated from the halophyte Limonium sinense. This strain can improve host seedling growth under salt stress conditions. We here report the complete genome information of endophyte KLBMP 4941. It has a circular chromosome and two plasmids for a total genome 4,104,242 bp in size with a G+C content of 38.09%. Genes related to plant growth promotion (PGP), such as those associated with nitrogen fixation, siderophore, spermidine, and acetoin synthesis were found in the KLBMP 4941 genome...
September 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28886510/polyamine-based-analogs-and-conjugates-as-antikinetoplastid-agents
#14
REVIEW
Elodie Jagu, Sébastien Pomel, Stéphanie Pethe, Philippe M Loiseau, Raphaël Labruère
Naturally occurring polyamines: putrescine, spermidine and spermine are crucial for Kinetoplastid growth and persistence. These aliphatic polycations are either biosynthesized or internalized into Kinetoplastid by active transport. Impairing the polyamine metabolism using polyamine derivatives is an interesting path in the search of new antikinetoplastid chemotherapy. In the past 30 years, research interest in this field has been constantly expanding and recent results demonstrated that the discovery of a polyamine-based antikinetoplastid drug is undoubtedly possible...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28886181/activation-of-endoplasmic-reticulum-stress-response-by-enhanced-polyamine-catabolism-is-important-in-the-mediation-of-cisplatin-induced-acute-kidney-injury
#15
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R Doherty, Mark A Hall, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleimani
Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with cisplatin. We hypothesized that enhanced polyamine catabolism contributes to tissue damage in cisplatin acute kidney injury (AKI). Using gene knockout and chemical inhibitors, the role of polyamine catabolism in cisplatin AKI was examined. Deficiency of SSAT, SMOX or neutralization of the toxic products of polyamine degradation, H2O2 and aminopropanal, significantly diminished the severity of cisplatin AKI...
2017: PloS One
https://www.readbyqxmd.com/read/28884675/sphingomonas-frigidaeris-sp-nov-isolated-from-an-air-conditioning-system
#16
Yunho Lee, Che Ok Jeon
A strictly aerobic Gram-stain-negative bacterium, designated strain KER25-10T, was isolated from a laboratory air conditioning system in South Korea. Cells were yellow-pigmented, non-motile rods showing catalase- and oxidase-positive reactions. The strain grew at pH 4.0-9.0 (optimum, pH 6.0-7.0) and 10-40 °C (optimum, 30 °C) and in the presence of 0-3 % (w/v) NaCl (optimum, 0 %). The G+C content of the genomic DNA was 65.1 mol%. Strain KER25-10T contained ubiquinone-10 (Q-10) as the predominant isoprenoid quinone and C16 : 0, C17 : 1ω6c, summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c) and summed feature 8 (comprising C18 : 1ω7c and/or C18 : 1ω6c) as the major fatty acids...
September 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28881427/active-site-geometry-of-a-novel-aminopropyltransferase-for-biosynthesis-of-hyperthermophile-specific-branched-chain-polyamine
#17
Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara
Branched-chain polyamines are found exclusively in thermophilic bacteria and Euryarchaeota and play essential roles in survival at high temperatures. In the present study, kinetic analyses of a branched-chain polyamine synthase from the hyperthermophilic archaeon Thermococcus kodakarensis (Tk-BpsA) were conducted, showing that N(4) -bis(aminopropyl)spermidine was produced by sequential additions of decarboxylated S-adenosyladenosine (dcSAM) aminopropyl groups to spermidine, through bifunctional catalytic action...
September 7, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28875898/microbacterium-hibisci-sp-nov-isolated-from-rhizosphere-of-mugunghwa-hibiscus-syriacus-l
#18
Zheng-Fei Yan, Pei Lin, Kyung-Hwa Won, Jung-Eun Yang, Chang-Tian Li, MooChang Kook, Qi-Jun Wang, Tae-Hoo Yi
A Gram-stain-positive, aerobic, non-motile, short-rod shaped actinobacterium, designated THG-T2.14T, was isolated from soil sampled from the rhizosphere of mugunghwa. Growth occurred at 10-40 °C (optimum 30 °C), at pH 5.0-10.0 (optimum 7.0) and at 0-7.0 % NaCl (optimum 3.0 %). Based on 16S rRNA gene sequence analysis, the nearest phylogenetic neighbours of strain THG-T2.14T were identified as Microbacterium yannicii DSM 23203T (98.8 %), Microbacterium trichothecenolyticum DSM 8608T (98.8 %), Microbacterium arthrosphaerae DSM 22421T (98...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28873527/enzymes-loaded-chitosan-coconut-fibre-zinc-oxide-nanoparticles-strip-for-polyamine-determination
#19
Vinita Hooda, Archita
Most often, the immobilized enzyme based quantification is an attractive alternative to other chromatographic, electrochemical and mass spectrometry based methods due to its specificity and simplicity. In the present study, polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for putrescine, were co-immobilized onto a novel chitosan/coconut fibre/zinc oxide nanoparticles (CS/CF/nZnO) hybrid support to yield a polyamine sensing strip. The strip worked optimally at pH 7.0, temperature 25°C and 6min of incubation time...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28869871/biochemical-characterization-and-homology-modeling-of-polyamine-oxidase-from-cyanobacterium-synechocystis-sp-pcc-6803
#20
Khanittha Samasil, Leonor Lopes de Carvalho, Pirkko Mäenpää, Tiina A Salminen, Aran Incharoensakdi
The intracellular polyamine contents are regulated not only by polyamine biosynthesis and transport but also by polyamine degradation catalyzed by copper-dependent amine oxidase (DAO) and FAD-dependent polyamine oxidase (PAO). The genome sequence of Synechocystis sp. PCC 6803 reveals the presence of at least one putative polyamine oxidase gene, slr5093. The open reading frame of slr5093 encoding Synechocystis polyamine oxidase (SynPAO, E.C. 1.5.3.17) was expressed in Escherichia coli. The purified recombinant enzyme had the characteristic absorption spectrum of a flavoprotein with absorbance peaks at 380 and 450 nm...
August 26, 2017: Plant Physiology and Biochemistry: PPB
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