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Paraoxonase activity and polymorphisms

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https://www.readbyqxmd.com/read/28467805/paraoxonase-1-pon1-induces-metastatic-potential-and-apoptosis-escape-via-its-antioxidative-function-in-lung-cancer-cells
#1
Mark Borris D Aldonza, Yeon Sung Son, Hye-Jin Sung, Jung-Mo Ahn, Young-Jin Choi, Yong-In Kim, Sukki Cho, Je-Yoel Cho
Paraoxonase-1 (PON1) gene polymorphisms have been closely associated with the development of advanced cancers while PON1 secretion to the serum is linked with inhibition of oxidized high-density lipoprotein by its antioxidative function. Our group previously demonstrated that post-translational modification of serum PON1 in form of fucosylated PON1 is a potential biomarker of small cell lung cancer. Here, we interrogated the role of PON1 in the pathobiology of lung cancer (LC) by addressing cell-autonomous mechanisms using gain-of-function and loss-of-function approaches and protein expression profiling of tissue samples in our clinical biobank...
April 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399619/association-of-paraoxonase-1-pon1-l55m-and-pon1-q192r-gene-polymorphisms-and-risk-of-psoriasis
#2
Göknur Kalkan, Havva Y Seçkin, İsmail Benli, Ali Akbaş, Ömer Ateş, Hüseyin Özyurt, Yalçın Baş, Atiye Oğrum, Günseli Ş Pancar
BACKGROUND: Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new aetiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1) activity. In this study, we aimed to examine the possible associations between the both PON1 L55M and PON1 Q192R polymorphisms and psoriasis susceptibility and disease progression in Turkish population...
April 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28196109/associations-between-pon1-enzyme-activities-in-human-ovarian-follicular-fluid-and-serum-specimens
#3
Keewan Kim, Michael S Bloom, Victor Y Fujimoto, Richard W Browne
The importance of high-density lipoprotein (HDL) particle components to reproduction is increasingly recognized, including the constituent paraoxonase 1 (PON1). However, the reliability characteristics of PON1 enzymes in ovarian follicular fluid (FF) as biomarkers for clinical and epidemiologic studies have not been described. Therefore, we characterized PON1 enzymes in FF and serum and assessed the impact of the PON1 Q192R polymorphism on associations between enzyme activities in two compartments. We also evaluated associations between HDL particle size and enzyme activities...
2017: PloS One
https://www.readbyqxmd.com/read/28185016/association-between-paraoxonase-1-gene-q192r-and-l55m-polymorphisms-in-systemic-lupus-erythematosus-sle-and-anti-phospholipid-syndrome-aps-in-a-population-from-cairo-of-egypt
#4
Alshaymaa Ahmed Ibrahim, Dalia El-Lebedy, Ingy Ashmawy, Maha Abdel Hady
Paraoxonase-1 (PON1) is involved in the oxidative stress process that cause tissue damage observed in systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). The aim of the present study was to investigate the association of PON1 Q192R and L55M polymorphisms with risk of SLE and associated APS among Egyptian sample. The study included 120 SLE patients (45 without APS and 75 with APS) and 120 healthy subjects. PON1 Q192R and L55M polymorphisms were genotyped by real-time PCR. No significant differences in Q192R genotypes or allele frequencies were found between patients and controls (p = 0...
February 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27863895/paraoxonase-1-q192r-gene-polymorphism-coronary-heart-disease-and-the-risk-of-a-new-acute-coronary-event
#5
Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores
INTRODUCTION: Paraoxonase 1 (PON1) plays a major role in the oxidation of low density lipoprotein and in the prevention of coronary atherogenesis. In this context, coding region polymorphisms of PON1 gene, responsible for the enzyme activity, has become of interest as a marker for atherogenesis. METHODS: A study and follow-up was conducted on 529 patients with an acute coronary event in order to assess the association between the PON1 Q192R (rs662;A/G) polymorphism, the type of acute coronary syndrome, cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidaemia, and smoking), the extent and severity of coronary atherosclerosis, and the medium-term clinical follow-up...
November 15, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27812605/paraoxonase-1-pon1-q192r-genotypes-and-their-interaction-with-smoking-strongly-increase-atherogenicity-and-the-framingham-risk-score
#6
Andre de Souza-Nogueira, Alissana Ester Camargo, Felipe Assan Remondi, Monica Maria Bastos Paoliello, Rebecca J Richter, Clement E Furlong, Decio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
Objective: Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PON1 status (functional 192 genotype and plasma activity levels) and atherogenicity in urbans residents aged 40 years or more. Materials and methods: Anthropometric data, lipid profiles, the atherogenic index of the plasma (AIP) and Framingham score risk were measured...
October 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27771368/paraoxonase-and-atherosclerosis-related-cardiovascular-diseases
#7
REVIEW
Dimitry A Chistiakov, Alexandra A Melnichenko, Alexander N Orekhov, Yuri V Bobryshev
In humans, three paraoxonase (PON1, PON2, and PON3) genes are clustered on chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly homologous to each other and have a similar protein structural organization. PON2 is the intracellular enzyme, which is expressed in many tissues and organs, while two other members of PON gene family are produced by liver and associate with high density lipoprotein (HDL). The lactonase activity is the ancestral. Besides lactones and organic phosphates, PONs can hydrolyze and therefore detoxify oxidized low density lipoprotein and homocysteine thiolactone, i...
January 2017: Biochimie
https://www.readbyqxmd.com/read/27748147/letter-to-the-editor-regarding-the-article-serum-paraoxonase-1-gene-polymorphism-and-enzyme-activity-in-patients-with-urolithiasis
#8
Huseyin Besiroglu, Mustafa Kadihasanoglu, Emin Ozbek
No abstract text is available yet for this article.
November 2016: Renal Failure
https://www.readbyqxmd.com/read/27693409/serum-paraoxonase-activity-in-relation-to-lipid-profile-in-age-related-macular-degeneration-patients
#9
Kannadasan AnandBabu, S R Bharathidevi, Sarangapani Sripriya, Parveen Sen, Vadivelu Jaya Prakash, Appukuttan Bindu, Natarajan Viswanathan, Narayanasamy Angayarkanni
Age-related Macular Degeneration (AMD) is a multifactorial disease causing visual impairment in old age. Oxidative stress is one of the main contributors for the disease progression. Paraoxonase (PON), a HDL-resident antioxidant enzyme which removes oxidized low density lipoprotein (oxLDL), which is not studied much in AMD. This study assesses the PON activities in relation to the lipid status and genetic variants in AMD patients. In this prospective case-control study, a total of 48 AMD patients and 30 unrelated healthy controls were recruited...
September 28, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27640339/paraoxonase-1-gene-polymorphisms-and-enzyme-activities-in-coronary-artery-disease-and-its-relationship-to-serum-lipids-and-glycemia
#10
Osvaldo Fridman, Luis Gariglio, Stephanie Riviere, Rafael Porcile, Alicia Fuchs, Miguel Potenzoni
OBJECTIVES: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. METHODS: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR...
October 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/27633038/pharmacological-interactions-of-paraoxonase-1-pon1-a-hdl-bound-antiatherogenic-enzyme
#11
Abdolkarim Mahrooz
A growing interest exists in documenting the role of paraoxonase 1 (PON1) in different human diseases including, cardiovascular disease, obesity, diabetes mellitus, cancers, aging, and several neurological disorders. Three aspects of PON1 have attracted the attention of researchers: (1) hydrolyzing and detoxifying of toxic organophosphorous compounds such as nerve gases; (2) antioxidative activity in hydrolyzing oxidized phospholipids in high-density lipoprotein (HDL) and low-density lipoprotein (LDL); (3) interaction with various drugs...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27510818/the-effect-of-hdl-bound-and-free-pon1-on-copper-induced-ldl-oxidation
#12
Ahmet Bayrak, Tülin Bayrak, Ebru Bodur, Kamer Kılınç, Ediz Demirpençe
Oxidative modification of LDL plays an important role in the development of atherosclerosis. High-density lipoprotein (HDL) confers protection against atherosclerosis and the antioxidative properties of paraoxonase 1 (PON1) has been suggested to contribute to this effect of HDL. The PON1 exist in two major polymorphic forms (Q and R), which regulate the concentration and activity of the enzyme and alter its ability to prevent lipid oxidation. However, the association of Q192R polymorphism with PON1's capacity to protect against LDL lipoperoxidation is controversial...
September 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27325068/paraoxonase-1-and-early-life-environmental-exposures
#13
REVIEW
Judit Marsillach, Lucio G Costa, Clement E Furlong
Acute and chronic exposures to widely used organophosphorus (OP) insecticides are common. Children's detoxification mechanisms are not well developed until several years after birth. The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. Paraoxonase-1 (PON1) is an enzyme that can detoxify OPs but its catalytic efficiency for hydrolysis to certain OPs is modulated by the Q192R polymorphism...
January 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27313824/a-genetic-biomarker-of-oxidative-stress-the-paraoxonase-1-q192r-gene-variant-associates-with-cardiomyopathy-in-ckd-a-longitudinal-study
#14
E Dounousi, I Bouba, B Spoto, K Pappas, G Tripepi, I Georgiou, A Tselepis, M Elisaf, D Tsakiris, C Zoccali, K Siamopoulos
Background. Oxidative stress is a hallmark of CKD and this alteration is strongly implicated in LV hypertrophy and in LV dysfunction. Methods and Patients. We resorted to the strongest genetic biomarker of paraoxonase-1 (PON1) activity, the Q192R variant in the PON1 gene, to unbiasedly assess (Mendelian randomization) the cross-sectional and longitudinal association of this gene-variant with LV mass and function in 206 CKD patients with a 3-year follow-up. Results. The R allele of Q192R polymorphism associated with oxidative stress as assessed by plasma 8-isoPGF2α (P = 0...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27213056/paraoxonase-1-and-simvastatin-treatment-in-patients-with-stable-coronary-artery-disease
#15
Rafał Januszek
Background. Paraoxonase-1 (PON1) is the crucial antioxidant marker of high-density lipoproteins. The present study is aimed at assessing the effect of simvastatin treatment on PON1 activity and its relationship to Q192R and M55L polymorphisms in subjects with stable coronary artery disease (CAD). Methods. The patient group was composed of 53 individuals with stable CAD, and the control group included 53 sex-matched police officers without CAD. CAD patients were treated with simvastatin 40mg/day for 12 months...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/27197424/paraoxonase-1-activity-and-pleiotropic-properties-of-simvastatin-in-obese-and-non-obese-patients-with-stable-coronary-artery-disease-cad
#16
Rafał Januszek
OBJECTIVES: The study was aimed to assess paraoxonase-1 (PON1) activity, pleiotropic effects of simvastatin, and its relationship to Q192R and M55L polymorphisms in obese and non-obese subjects with stable coronary artery disease (CAD). PATIENTS AND METHODS: The study included 53 subjects (22 obese) aged from 35 to 65 years with CAD. The control group consisted of 53 (18 obese) police officers without CAD. Patients with CAD were treated with simvastatin 40 mg/day for 12 months...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27166546/q192r-paraoxonase1-polymorphism-is-a-risk-factor-for-cataract-in-pakistani-population
#17
Amena Baig, Muhammad Zohaib, Ata-ur Rehman, Shamshad Zarina
Cataract, the lens opacity, is among major causes of blindness in Pakistani population. In recent past, oxidative stress is suggested to play crucial role in loss of transparency. Along with other antioxidants, Paraoxonase 1 (PON1) has also shown decreased activity in patients suffering from cataract. The aim of current study was to examine the possible association of PON polymorphism with predisposition of cataract formation in local population. The study was conducted on 51 cataract patients and 50 control subjects considering all ethical issues...
May 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27087156/the-rs662-polymorphism-of-paraoxonase-1-affects-the-difference-in-the-inhibition-of-butyrylcholinesterase-activity-by-organophosphorus-pesticides-in-human-blood
#18
Dae Cheol Nam, Yu Mi Ha, Min Kyu Park, Sung Kweon Cho
OBJECTIVES: Organophosphorus pesticides (OPs) are a human health hazard. OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. High levels of ACh and long exposure promote cholinergic crisis. The hydrolysis of OPs by serum paraoxonase 1 (PON1) plays a role in cholinergic crisis in humans. Human serum PON1 can break down organophosphate before binding to ChE. We investigated the effect of PON1 polymorphisms on AChE activity after OP treatment...
August 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27069323/association-of-type-ii-5-monodeiodinase-thr92ala-single-nucleotide-gene-polymorphism-and-circulating-thyroid-hormones-among-type-2-diabetes-mellitus-patients
#19
Dhanunjaya Yalakanti, Pragna B Dolia
Diabetes mellitus and thyroid disorders are common endocrinopathies, which often occur parallel. Dyslipidemia is very common in both of these conditions. The development of hypothyroidism is well-known in type 1 diabetics, but it was not distinctly understood in type 2 diabetics. Thus we tried to examine the association between type II deiodinase (D2 or DIO2) Thr92Ala single nucleotide gene polymorphism and thyroid function among type 2 diabetes mellitus patients. A total of 130 type 2 diabetics were screened and genotyped for DIO2 Thr92Ala polymorphism...
April 2016: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/27062891/activity-and-determinants-of-cholinesterases-and-paraoxonase-1-in-blood-of-workers-exposed-to-non-cholinesterase-inhibiting-pesticides
#20
David Lozano-Paniagua, Antonio Gómez-Martín, Fernando Gil, Tesifón Parrón, Raquel Alarcón, Mar Requena, Marina Lacasaña, Antonio F Hernández
Pesticide exposure has been associated with different adverse health effects which may be modulated to some extent by paraoxonase-1 (PON1) activity and genetic polymorphisms. This study assessed seasonal variations in PON1 activity (using paraoxon -POase-, phenylacetate -AREase-, diazoxon -DZOase- and dihydrocoumarin -DHCase- as substrates), erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (using butyrylthiocholine -BuChE- and benzoylcholine -BeChE- as substrates. The study population consisted of intensive agriculture workers regularly exposed to pesticides other than organophosphates and non-exposed controls from Almería (Southeastern Spain)...
November 25, 2016: Chemico-biological Interactions
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