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Ki Chul Park, Chang-Wug Oh, Young-Hoon Jo
INTRODUCTION: Managing subchondral bone defects in proximal tibia fractures after plateau reduction is an important consideration.ChronOSInjectis a recently developed calcium phosphate bone substitute that shows relatively fast osteointegration. HYPOTHESIS: UsingchronOS Inject during internal fixation of proximal tibial fractures provides a satisfactory treatment option that is both clinically and radiologically safe. MATERIALS AND METHODS: Patients enrolled in this study were treated with ChronOS Injectbone void filler, during internal fixation of proximal tibial fractures...
November 21, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen, Chih-Yu Wu, Shih-Torng Ding, Hsien-Yeh Chen
The ability to induce osteointegration was introduced to a parylene-C surface via the simple and intuitive process of protein adsorption mediated by hydrophobic interactions. In this way, bone morphogenetic protein (BMP)-2, fibronectin, and platelet-rich plasma (PRP) could be immobilized on parylene-C surfaces. This approach alleviates concerns related to the use of potentially harmful substances in parylene-C modification processes. The adsorbed protein molecules were quantitatively characterized with respect to adsorption efficacy and binding affinity, and the important biological activities of the proteins were also examined using both early and late markers of osteogenetic activity, including alkaline phosphatase expression, calcium mineralization and marker gene expression...
October 26, 2016: Biomaterials Science
Julia Hehn, Thomas Schwenk, Markus Striegel, Markus Schlee
BACKGROUND: Previous studies have shown that adequate thickness or initial augmentation of soft tissue has a positive effect on the stability of peri-implant bone. This randomized, controlled trial aimed to evaluate the influence of augmenting soft tissue with platelet-rich fibrin (PRF) on crestal bone and soft tissue around implants. METHODS: After randomization, 31 fully threaded titanium implants were inserted in 31 patients (16 men and 15 women) in the lower mandible using a split-flap technique...
December 2016: International Journal of Implant Dentistry
Philippe Bousquet, Hélène Ansermino, Pierre Canal, Matthieu Renaud, Christèle Artz
Using implant to replace a tooth is a well known treatment. However, the practitioner must keep in mind that osteointegrated implants behave like ankylosed teeth, and their evolution does not follow the alveolar processes of the adjacent teeth during growth. This growth decreases after 20 years, but remains present. This can lead to infraposition functionally and aesthetically failure for the implant therapy. Risk factors, like patient's age, sex and shape of the face must be evaluated. Most palatal implant positioning and use of screwed prosthetic tooth can permit the infraposition treatment during years of aging...
September 2016: L' Orthodontie Française
Gao Ying, Lian Bo, Jiao Yanjun, Wu Lina, Wang Binquan
INTRODUCTION: Local application of bisphosphonates has been proven to be safer than systemic administration to promote implant fixation. The objective of this study was to introduce such a simple, convenient and efficient method to enhance titanium (Ti) implant osseointegration in ovariectomized (OVX) rats. MATERIAL AND METHODS: Twenty female Sprague-Dawley rats sequentially underwent bilateral ovariectomy and tibia implantation, and injection of 30 µg/implant zoledronic acid (ZOL) at the site of implantation was performed...
October 1, 2016: Archives of Medical Science: AMS
Ujjal K Bhawal, Ryoichiro Uchida, Noboru Kuboyama, Tetsuo Asakura, Koichi Hiratsuka, Norihiro Nishiyama
Existing scaffolds cannot adequately satisfy the simultaneous requirements for the regeneration of bone. The challenge remains of how to improve the integration of newly formed bone with the surrounding tissues. The purpose of this study was to investigate the effects of two silk fibroin scaffolds, a hexafluoro isopropanol-based silk fibroin (HFIP-F) and an aqueous-based silk fibroin (A-F), for their osteoinductive potentials in large critical size bone defects in vivo. β-tricalcium phosphate (β-TCP) was used as a positive control...
September 28, 2016: Bio-medical Materials and Engineering
Antonio Cortese, Giuseppe Pantaleo, Antonio Borri, Mario Caggiano, Massimo Amato
INTRODUCTION: Some studies have demonstrated that platelet rich fibrin (PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions and may be used alone or in combination with bone grafts, promoting hemostasis, bone growth, and maturation. PRF appears as a natural and satisfactory aid in bone regenerative surgery in elderly patients with favorable results and low risks. AIM: This study wants to demonstrate how PRF in association with a new split crest augmentation technique can be a great aid in implant rehabilitation, especially in the elderly patients, when bone regeneration is required...
September 22, 2016: International Journal of Surgery Case Reports
Zongliang Wang, Li Chen, Yu Wang, Xuesi Chen, Peibiao Zhang
A nanocomposite of poly(lactide-co-glycolide) (PLGA) and hydroxyapatite (HA) with a different grafting ratio of l-lactic acid oligomer (op-HA) showed better interface compatibility, mineralization, and osteogenetic abilities. However, surface modification of the composite is crucial to improve the osteointegration for bone regeneration. In this study, a biomimetic process via poly(dopamine) coating was utilized to prepare functional substrate surfaces with immobilized bioactive peptides that efficiently regulate the osteogenic differentiation of preosteoblasts (MC3T3-E1)...
October 12, 2016: ACS Applied Materials & Interfaces
Lin Wang, Xiaofan Hu, Xiangyu Ma, Zhensheng Ma, Yang Zhang, Yizhao Lu, Xiang Li, Wei Lei, Yafei Feng
Clinical evidence indicates a high failure rate for titanium implants (TiI) in diabetic patients, involving the overproduction of reactive oxygen species (ROS) at the implant/bone interface. Tantalum coating on titanium (TaTi) has exerted better tissue integration properties than TiI, but its biological performance under diabetic conditions remains elusive. To investigate whether TaTi may ameliorate diabetes-induced implant destabilization and the underlying mechanisms, primary rabbit osteoblasts cultured on 3-dimensional printed TiI and TaTi were exposed to normal serum (NS), diabetic serum (DS), DS+NAC (a potent ROS inhibitor), and DS+SB203580 (a specific p38 MAPK inhibitor)...
September 14, 2016: Colloids and Surfaces. B, Biointerfaces
Norbert Harrasser, Michael de Wild, Johannes Gorkotte, Andreas Obermeier, Susanne Feihl, Melanie Straub, Ruediger von Eisenhart-Rothe, Hans Gollwitzer, Jasmine Rüegg, Walter Moser, Philipp Gruner, Rainer Burgkart
BACKGROUND: Silver ions (Ag+) have strong antibacterial effects, and silver-coated materials are in widespread clinical use. However, the application of silver-coated medical devices is not without concerns: its use with direct bone contact is not established, and systemic toxic side effects of released Ag+ have been described. Therefore, alternative bactericidal coatings with a more localized way of acting - e.g., calcium dihydroxide, Ca(OH)2 (CH) - would be advantageous. METHODS: A new rat model of the animal's tibial metaphysis was developed...
September 17, 2016: Journal of Applied Biomaterials & Functional Materials
F Diomede, N Zini, V Gatta, S Fulle, I Merciaro, M D'Aurora, R M La Rovere, T Traini, J Pizzicannella, P Ballerini, S Caputi, A Piattelli, O Trubiani
The purpose of this work was to test, in vitro and in vivo, a new tissue-engineered construct constituted by porcine cortico-cancellous scaffold (Osteobiol Dual Block) (DB) and xeno-free ex vivo culture of human Periodontal Ligament Stem Cells (hPDLSCs). hPDLSCs cultured in xeno-free media formulation preserved the stem cells' morphological features, the expression of stemness and pluripotency markers, and their ability to differentiate into mesenchymal lineage. Transmission electron microscopy analysis suggested that after one week of culture, both noninduced and osteogenic differentiation induced cells joined and grew on DB secreting extracellular matrix (ECM) that in osteogenic induced samples was hierarchically assembled in fibrils...
2016: European Cells & Materials
Sunil Kumar Karumuri, Trisha Rastogi, Kartheeki Beeraka, Mohan Raju Penumatcha, Sanjeeva Rao Olepu
An ultrasound (US) gives a visible image of the organs that are present inside the body. In medicine it serves for diagnosing and also its therapeutic benefits are well established for bone healing, osteointegration and soft tissue healing. In dentistry it is widely used for diagnostic purposes. When it was discovered it was introduced for therapeutic purposes, but due to lack of clinical studies its use as therapy was remittent in dentistry. The aim of the present paper was to establish the efficiency of therapeutic US in maxillofacial region for alleviating the pain and to see the other applications...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Shishu Huang, Nuanyi Liang, Yang Hu, Xin Zhou, Noureddine Abidi
Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed...
2016: BioMed Research International
Hao Tang, Dejin Yang, Shengjie Guo, Jing Tang, Jian Liu, Dacheng Wang, Yixin Zhou
OBJECTIVES: For postoperative imaging assessment of cementless hip arthroplasty, radiography and computed tomography (CT) were restricted by overlapping structures and metal artifacts, respectively. A new tomosynthesis with metal artifact reduction (TMAR) is introduced by using metal extraction and ordered subset-expectation maximization (OS-EM) reconstruction. This study investigated the effectiveness of TMAR in assessing fixation stability of cementless hip arthroplasty components. MATERIALS AND METHODS: We prospectively included 48 consecutive patients scheduled for revision hip arthroplasty in our hospital, with 41 femoral and 35 acetabular cementless components available for evaluation...
November 2016: Skeletal Radiology
Paolo Trisi, Marco Berardini, Marco Colagiovanni, Davide Berardi, Giorgio Perfetti
PURPOSE: The aim of the present histological and biomechanical analysis was to compare, in vivo, the strength and quality of osseointegration between a laser-treated implant surface and a standard machined surface. MATERIAL AND METHODS: Customized titanium implants, having 2 different surfaces, were used. Implants were longitudinally split in the 2 surfaces: one side was laser treated and the opposite one had a machined surface. Eight implants were inserted in the iliac crest of 2 sheep: 4 with a split laser and machined surfaces, 2 with a completely laser-treated surface, and 2 with fully machined surfaces...
October 2016: Implant Dentistry
Y-M Chang, Y-H Pan, Y-F Shen, J-K Chen, N F ALDeek, F-C Wei
We have evaluated the survival of dental implants placed in vascularised fibular flap onlay grafts placed over marginal mandibulectomies and the effects on marginal bone loss of different types of soft tissue around implants under functional loading. From 2001-2009 we studied a total of 11 patients (1 woman and10 men), three of whom had had ameloblastoma and eight who had had squamous cell carcinomas resected. A total of 38 dental implants were placed either at the time of transfer of the vascularised fibular ostoseptocutaneous flaps (nine patients with 30 implants) or secondarily (two patients with eight implants)...
August 8, 2016: British Journal of Oral & Maxillofacial Surgery
D Liu, Y J Gong, Q Xiao, Z A Li
OBJECTIVE: To study the effect of poly(ethylene glycol)methacrylate(PEG)-arginine-glycine-aspartic(RGD)polymer brushes graft on bacterial adhesion and MC3T3 osteoblast cell attachment on titanium, and to investigate if the modification of titanium will enable the implant to be anti-fouling and promot osteointegration. METHODS: PEG was tethered on titanium surface modified with 2-bromoisobutyryl bromide(denoted as Ti-Br)to form Ti-PEG brushes. Functionalization of the Ti-PEG surface with RGD was performed to form Ti-PEG-RGD brushes...
August 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Miriam López-Álvarez, Eva Vigo, Cosme Rodríguez-Valencia, Verónica Outeiriño-Iglesias, Pío González, Julia Serra
OBJECTIVE: The present work proposes the shark teeth as a new source of bioapatites for bone filler applications in maxillary sinus elevation, periodontal regeneration or implants placement. This abundant fishing by-product provides an improved hydroxyapatite (HA) with fluorine contributions. The in vivo evaluation of osteointegration and bone mineral density levels promoted by these marine bioapatites was the main objective. MATERIALS AND METHODS: Marine bioapatite granules of two sizes (1 mm, <20 μm) were obtained and characterized (XRD, SEM, ICP-OES) to determine morphology and composition...
August 5, 2016: Clinical Oral Implants Research
Sepideh Mostofi, Ehsan Bonyadi Rad, Helmar Wiltsche, Ulrike Fasching, Gabor Szakacs, Claudia Ramskogler, Sriveena Srinivasaiah, Muammer Ueçal, Regine Willumeit, Annelie-Martina Weinberg, Ute Schaefer
This study investigated the effect of biodegradable Mg and Mg alloys on selected properties of MC3T3-E1 cells elicited by direct cell/material interaction. The chemical composition and morphology of the surface of Mg and Mg based alloys (Mg2Ag and Mg10Gd) were analysed by scanning electron microscopy (SEM) and EDX, following corrosion in cell culture medium for 1, 2, 3 and 8 days. The most pronounced difference in surface morphology, namely crystal formation, was observed when Pure Mg and Mg2Ag were immersed in cell medium for 8 days, and was associated with an increase in atomic % of oxygen and a decrease of surface calcium and phosphorous...
2016: PloS One
Stephan F Schindele, Christoph M Sprecher, Stefan Milz, Stefanie Hensler
INTRODUCTION: Primary press fit and secondary osteointegration is a precondition for component anchoring in articular surface replacements, also in the case of proximal interphalangeal (PIP) joint. Nevertheless, many existing prostheses for the PIP joint have failed to show sufficient osteointegration. CapFlex-PIP(©) implant is a modular metal-polyethylene surface replacement for the PIP joint consisting of a proximal and distal component each having a titanium pore backside, which allows secondary osteointegration at the bone-implant interface...
September 2016: Archives of Orthopaedic and Trauma Surgery
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