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Osteointegration

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https://www.readbyqxmd.com/read/29660634/comparison-of-osteointegration-property-between-pekk-and-peek-effects-of-surface-structure-and-chemistry
#1
Bo Yuan, Qinwen Cheng, Rui Zhao, Xiangdong Zhu, Xiao Yang, Xi Yang, Kai Zhang, Yueming Song, Xingdong Zhang
Weak osteointegration affects the long-term stability of polyaryletherketone (PAEK) implants. Surface modification provides a potential solution to improve the osteointegration property of PAEKs. Polyetheretherketone (PEEK) and polyetherketoneketone (PEKK) are two representative PAEK materials, but the former has more ketone groups and better potential for surface chemical modification than the latter. In this work, porous PEKK (PEKK-P) and PEEK (PEEK-P) were fabricated by a porogen leaching method. The samples were treated with 80% sulfuric acid (PEKK-SP and PEEK-SP) and then simulated body fluid (SBF) incubation (PEKK-BSP and PEEK-BSP)...
April 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29649637/angiogenesis-impairment-by-the-nadph-oxidase-triggered-oxidative-stress-at-the-bone-implant-interface-critical-mechanisms-and-therapeutic-targets-for-implant-failure-under-hyperglycemic-conditions-in-diabetes
#2
Xiao-Fan Hu, Lin Wang, Geng Xiang, Wei Lei, Ya-Fei Feng
Mechanism underlying the diabetes-induced poor osteointegration of implants remains elusive, making it a challenge to develop corresponding solutions. Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant interface (BII) and the related mechanisms. In vivo, titanium screws were implanted in the femurs of mice, and, in vitro, vascular endothelial cell (VEC) was cultured on titanium surface. Results showed that, compared with normal milieu (NM), diabetic milieu (DM) led to angiogenesis inhibition around implants which resulted in reduced osteoprogenitors and poor bone formation on BII in vivo...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29602957/nanotechnology-the-scope-and-potential-applications-in-orthopedic-surgery
#3
EDITORIAL
Ashok Gavaskar, D Rojas, F Videla
Nanotechnology involves manipulation of matter measuring 1-100 nm in at least one of its dimensions at the molecular level. Engineering and manipulation of matter at the molecular level has several advantages in the field of medicine (nanomedicine) since most of the biological molecules exist and function at a nanoscale. Though promising, questions still remain on how much of this will ultimately translate into achieving better patient care. Concerns of cost-effectiveness and nanotechnology safety still remain unclear...
March 30, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29596358/porous-polyethylene-coated-with-functionalized-hydroxyapatite-particles-as-a-bone-reconstruction-material
#4
H Fouad, Randa AlFotawi, Othman Y Alothman, Basheer A Alshammari, Musaad Alfayez, Mohamed Hashem, Amer Mahmood
In this study, porous polyethylene scaffolds were examined as bone substitutes in vitro and in vivo in critical-sized calvarial bone defects in transgenic Sprague-Dawley rats. A microscopic examination revealed that the pores appeared to be interconnected across the material, making them suitable for cell growth. The creep recovery behavior of porous polyethylene at different loads indicated that the creep strain had two main portions. In both portions, strain increased with increased applied load and temperature...
March 29, 2018: Materials
https://www.readbyqxmd.com/read/29572572/osseointegration-mechanisms-a-proteomic-approach
#5
N Araújo-Gomes, F Romero-Gavilán, I García-Arnáez, C Martínez-Ramos, A M Sánchez-Pérez, M Azkargorta, F Elortza, J J Martín de Llano, M Gurruchaga, I Goñi, J Suay
The prime objectives in the development of biomaterials for dental applications are to improve the quality of osseointegration and to short the time needed to achieve it. Design of implants nowadays involves changes in the surface characteristics to obtain a good cellular response. Incorporating osteoinductive elements is one way to achieve the best regeneration possible post-implantation. This study examined the osteointegrative potential of two distinct biomaterials: sandblasted acid-etched titanium and a silica sol-gel hybrid coating, 70% MTMOS-30% TEOS...
March 23, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29563493/accelerated-and-enhanced-osteointegration-of-mao-treated-implants-histological-and-histomorphometric-evaluation-in-a-rabbit-model
#6
Xin Li, Haiyang Xu, Baodong Zhao, Shuai Jiang
Microarc oxidation (MAO) has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface (SF) implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model, a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses...
March 22, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29549709/-risk-factors-generally-neglected-in-oral-surgery-and-implantology-the-high-ldl-cholesterol-and-the-insufficient-level-of-vitamin-d
#7
K Waskiewicz, O Oth, N Kochan, L Evrard
INTRODUCTION: Vitamin D deficiency is widespread throughout the world. Vitamin D has an important role in the regulation of phosphocalcic metabolism as well as in a large number of biological and metabolic processes. According to some studies, there is a correlation between vitamin D and LDL-cholesterol levels. A deficiency of vitamin D and / or a high level of LDL-cholesterol could represent risk factors for bone healing and osteointegration of dental implants. The purpose of our study is to demonstrate the reality of the problem of deficiency or deprivation in vitamin D in a population of patients requiring oral and / or implant surgery...
February 23, 2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29525099/tuning-biological-properties-of-poly-vinyl-alcohol-with-amino-acids-and-studying-its-influence-on-osteoblastic-cell-adhesion
#8
S Mohanapriya, V Raj
A new class of bio composite materials for orthopedic applications were prepared by blending polyvinyl alcohol (PVA) with certain amino acids (AA) such as glycine, lysine and phenyl alanine followed by in-situ cross-linking with citric acid (CT). CT cross-linked PVA offers sufficient chemical, thermal, and morphological stability by establishing intermolecular interaction. These biocomposite films were characterized for mechanical and thermal behaviors as well as analyzed through SEM, TGA and AFM studies. Zwitterionic characteristics of AA create cell-adhesive hydrophilic domains that act as potential cell-adhesion sites and facilitate osteointegration...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29511448/co-injection-of-human-adipose-stromal-cells-and-rhbmp-2-fibrin-gel-enhances-tendon-graft-osteointegration-in-a-rabbit-anterior-cruciate-ligament-reconstruction-model
#9
Ping Chen, Jun Ouyang, Jiangwei Xiao, Zhongyu Han, Qiang Yu, Jing Tian, Li Zhang
The objective of this study was to investigate whether the co-injection of human adipose stromal cells (hASCs) and rhBMP-2/fibrin gel into the bone tunnels of anterior cruciate-ligament reconstructions can effectively enhance tendon graft osteointegration. We performed bilateral reconstructions using autologous semitendinosus tendons in 45 New Zealand rabbits, which we divided into three groups. We injected the bone tunnels with fibrin gel for group 1, rhBMP-2 (1 μg/ml)/fibrin gel for group 2, and hASCs wrapped in rhBMP-2 (1 μg/ml)/fibrin gel for group 3...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29489380/surface-functionalization-of-ti6al4v-via-self-assembled-monolayers-for-improved-protein-adsorption-and-fibroblast-adhesion
#10
Abshar Hasan, Varun Saxena, Lalit M Pandey
Although metallic biomaterials find numerous biomedical applications, their inherent low bioactivity and poor osteointegration had been a great challenge since decades. Surface modification via silanization can serve as an attractive method for improving aforementioned properties of such substrates. However, its effect on protein adsorption/conformation and subsequent cell adhesion and spreading, has rarely been investigated. This work reports the in-depth study of the effect of Ti6Al4V surface functionalization on protein adsorption and cell behaviour...
February 28, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29484904/dual-effect-biodegradable-ciprofloxacin-loaded-implantable-matrices-for-osteomyelitis-controlled-release-and-osteointegration
#11
Ahmed F Hanafy, Hany S M Ali, Samar N Elachy, El-Sayed E Habib
Ciprofloxacin biodegradable implantable matrices (CPX-IMs) of tailored porous surfaces were fabricated by hot melt injection molding of poly L-lactic acid (PLLA) followed by coating with PLLA/sodium chloride. CPX-IDs were designed to have a non-porous coat (NPC) or a porous coat of small pore size150-250 µm (SPC) or a large pore size 250-350µm (LPC). CPX-IMs surface pore size was confirmed by scanning electron microscope. Hardness of NPC, LPC and SPC CPX-IMs were 58±2.8, 53±1.9, and 50±2.1 N respectively...
February 27, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29477893/titanium-surface-bio-functionalization-using-osteogenic-peptides-surface-chemistry-biocompatibility-corrosion-and-tribocorrosion-aspects
#12
Luciana D Trino, Erika S Bronze-Uhle, Amsaveni Ramachandran, Paulo N Lisboa-Filho, Mathew T Mathew, Anne George
Titanium (Ti) is widely used in biomedical devices due to its recognized biocompatibility. However, implant failures and subsequent clinical side effects are still recurrent. In this context, improvements can be achieved by designing biomaterials where the bulk and the surface of Ti are independently tailored. The conjugation of biomolecules onto the Ti surface can improve its bioactivity, thus accelerating the osteointegration process. Ti was modified with TiO2 , two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) and dentin matrix protein 1 (DMP1) peptides...
February 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29473219/soft-tissue-dehiscence-coverage-at-peri-implant-sites
#13
REVIEW
Claudio Mazzotti, Martina Stefanini, Pietro Felice, Valentina Bentivogli, Ilham Mounssif, Giovanni Zucchelli
Soft-tissue dehiscence at the facial aspect of an osteointegrated implant is a common complication which impacts on the final esthetic result. The etiology and ways of diagnosing this condition are still controversial. Many factors seem to influence the position of the peri-implant soft-tissue margin, and some of these have been studied more carefully than others. Various surgical and combination surgical-prosthetic approaches have been described to treat soft-tissue dehiscence, with the latter appearing to be more predictable...
February 23, 2018: Periodontology 2000
https://www.readbyqxmd.com/read/29461402/management-of-mangled-extremities-and-orthopaedic-war-injuries
#14
Todd O McKinley, Jean-Claude DʼAlleyrand, Ian Valerio, Seth Schoebel, Kevin Tetsworth, Eric A Elster
In 16 years of conflict, primarily in Iraq and Afghanistan, wounded warriors have primarily been subjected to blast type of injuries. Evacuation strategies have led to unprecedented survival rates in blast-injured soldiers, resulting in large numbers of wounded warriors with complex limb trauma. Bone and soft tissue defects have resulted in increased use of complex reconstructive algorithms to restore limbs and function. In addition, in failed salvage attempts, advances in amputation options are being developed...
March 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29450763/effects-of-915-nm-laser-irradiation-on-human-osteoblasts-a-preliminary-in-vitro-study
#15
Giovanni Mergoni, Paolo Vescovi, Silvana Belletti, Jacopo Uggeri, Samir Nammour, Rita Gatti
Photobiomodulation (PBM) is a non-invasive treatment that uses laser or led devices making its effects a response to light and not to heat. The possibility of accelerating dental implant osteointegration and orthodontic movements and the need to treat refractory bone lesions, such as bisphosphonate related osteonecrosis of the jaws, has led researchers to consider the effects of PBM on bone for dentistry purposes. The aim of our study was to investigate the effects of 915 nm light supplied with a GaAs diode laser on human osteoblasts in vitro...
February 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29366729/accuracy-of-digital-tomosynthesis-with-metal-artifact-reduction-for-detecting-osteointegration-in-cementless-hip-arthroplasty
#16
Shengjie Guo, Hao Tang, Yixin Zhou, Yong Huang, Hongyi Shao, Dejin Yang
BACKGROUND: Cementless hip arthroplasty is increasingly gaining popularity worldwide. Radiologic identification of osteointegration is key to confirming biologic fixation. We conducted the study reported here to determine the sensitivity and specificity of digital tomosynthesis with metal artifact reduction (TMAR), radiography, and conventional computed tomography in detecting osteointegration in cementless hip arthroplasty. METHODS: We prospectively included data for 24 patients who underwent revision hip arthroplasty in our hospital, with 13 femoral and 14 acetabular cementless components retrieved that contained solid evidence of biologic fixation...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29331906/strontium-hydroxyapatite-scaffolds-engineered-with-stem-cells-aid-osteointegration-and-osteogenesis-in-osteoporotic-sheep-model
#17
Sunitha Chandran, Sachin J Shenoy, Suresh Babu S, Renjith P Nair, Varma H K, Annie John
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs)...
March 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29326508/effect-of-ultraviolet-irradiation-on-the-osseointegration-of-a-titanium-alloy-with-bone
#18
Ashish Yadav, Ranjana Yadav, Aratee Gupta, Akash Baranwal, Atul Bhatnagar, Vakil Singh
Introduction: Attempt has been made to analyze the potential of titanium (Ti) alloy for osteointegration by the effect of surface photo functionalization in different aspects as follows: in Ringer's solution, in vitro cell growth, and in vivo study on rabbit. The present study was aimed to investigate the influence of ultraviolet (UV) light on surface topography, corrosion behavior, and bioactivity of indigenously manufactured samples of Ti alloy mini-implant. Materials and Methods: The study includes surface modification of Ti samples by UV treatment, corrosion testing of the specimens using Potentiostat (GAMRY System), qualitative examination of modified surface topography using scanning electron microscope, and cellular viability test on Ti alloy surface (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ASSAY)...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29273059/biomechanical-properties-of-3d-printed-bone-scaffolds-are-improved-by-treatment-with-crfp
#19
Carlos G Helguero, Vamiq M Mustahsan, Sunjit Parmar, Sahana Pentyala, John L Pfail, Imin Kao, David E Komatsu, Srinivas Pentyala
BACKGROUND: One of the major challenges in orthopedics is to develop implants that overcome current postoperative problems such as osteointegration, proper load bearing, and stress shielding. Current implant techniques such as allografts or endoprostheses never reach full bone integration, and the risk of fracture due to stress shielding is a major concern. To overcome this, a novel technique of reverse engineering to create artificial scaffolds was designed and tested. The purpose of the study is to create a new generation of implants that are both biocompatible and biomimetic...
December 22, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29237352/influence-of-patterned-titanium-coatings-on-polarization-of-macrophage-and-osteogenic-differentiation-of-bone-marrow-stem-cells
#20
Zequan Zhang, Youtao Xie, Houhua Pan, Liping Huang, Xuebin Zheng
Biomaterial surface topography plays a vital role in the osteointegration of implants by regulating the early cell responses and tissue growth-in. However, most of the previous researches focused on the effects of osteogenic cells, only a little is known about the immune cells which dominate osteogenesis after implanting. In this paper, patterned titanium coatings were fabricated and the effects of surface topography on the macrophage behaviors were investigated. On patterned titanium surface, macrophages preferred to polarize to M2, while macrophages on traditional titanium coatings presented higher M1 polarization...
February 2018: Journal of Biomaterials Applications
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