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Osteointegration

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https://www.readbyqxmd.com/read/28341184/global-fit-concept-in-revision-hip-arthroplasty-for-cementless-press-fit-femoral-stems
#1
F Canovas, P LeBeguec, J Batard, F Gaillard, L Dagneaux
A revision stem may be required after a femoral extended trochanteric osteotomy (ETO) is made during revision hip arthroplasty. The two main complications of straight cementless femoral stems are subsidence due to inadequate osteointegration and stress-shielding. We will describe an original revision method with ETO that uses a straight cementless stem. The goal of this method was to achieve the most extensive press-fit possible during stem implantation to improve the transmission of stresses to the bone and to prevent reduction in bone density...
March 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28323714/osteointegration-and-resorption-of-intravertebral-and-extravertebral-calcium-phosphate-cement
#2
Roman Klein, Ralf Tetzlaff, Christel Weiss, Meike-Kristina Schäfer, Michael Tanner, Bernd Wiedenhöfer, Ingo Grafe, Peter-Jürgen Meeder, Gerd Noeldge, Peter P Nawroth, Christian Kasperk
STUDY DESIGN: Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial. OBJECTIVE: This study investigates long-term radiomorphologic features of intraosseous CaP cement implants and of extraosseous CaP cement leakages for up to 3 years after implantation by kyphoplasty. SUMMARY OF BACKGROUND DATA: Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28321783/biological-and-mechanical-effects-of-micro-nanostructured-titanium-surface-on-an-osteoblastic-cell-line-in-vitro-and-osteointegration-in-vivo
#3
Jingzu Hao, Ying Li, Baoe Li, Xiaolin Wang, Haipeng Li, Shimin Liu, Chunyong Liang, Hongshui Wang
Hybrid micro-nanostructure implant surface was produced on titanium (Ti) surface by acid etching and anodic oxidation to improve the biological and mechanical properties. The biological properties of the micro-nanostructure were investigated by simulated body fluid (SBF) soaking test and MC3T3-E1 cell co-culture experiment. The cell proliferation, spreading, and bone sialoprotein (BSP) gene expression were examined by MTT, SEM, and reverse transcription-polymerase chain reaction (RT-PCR), respectively. In addition, the mechanical properties were evaluated by instrumented nanoindentation test and friction-wear test...
March 20, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28300879/behavior-study-of-the-doped-castor-bean-polymer-rod-with-bioactive-glass-and-hidroxyapatite-in-mice-femur-medullary-canal
#4
Viviani Teixeira Dos Santos, Gilberto Gonçalves Facco, Hudman Cunha Ortiz, Iandara Schettert da Silva
Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A - doped castor bean polymer with bioactive glass; group B - castor bean polymer and; group C - castor bean polymer doped with bioactive glass and hydroxyapatite. After 15 and 60 evaluation days, the femurs were removed and sent for histology and scanning electron microscopy...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28293511/de-novo-reconstruction-of-a-hybrid-patella-by-staged-fabrication-of-a-microvascular-bone-transplant-with-an-osteointegrated-prosthetic-socket
#5
Goetz A Giessler, Christian Hendrich
Total patellectomy is sometimes unavoidable but usually results in severely impaired function, pain, and instability in the affected knee. Any patellar prosthetic solutions rely on a certain amount of remaining bone and therefore are not applicable after total patellectomy. Traditionally, reconstruction of a neopatella by avascular or allogeneic bone grafts is hampered by mechanical failure, resorption, or infection. We developed a new, 3-stage approach to reconstruct a hybrid patella composed of a revascularized scapula tip transplant fabricated with a prosthetic socket...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28228785/mesenchymal-stem-cells-in-post-surgical-cavities-of-large-maxillary-bone-lesions
#6
Roberto Bertolai, Carlo Catelani, Mattia Signorini, Alessandro Rossi, Domenico Giannini
BACKGROUND: Recent studies have highlighted that MSCs are capable of regenerating large bone defects when used in combination with bone substitutes and increasing allo-graft osteointegration. We investigated the hypothesis that autologous MSCs may lead to increased bone regeneration and reduced healing time in post-surgical cavities of large maxillary bone lesions. METHODS: This study involved 10 patients (TEST GROUP) (6 males and 4 females). All patients had expansive mandibular lesions larger than 3 cm...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28221007/ionic-colloidal-molding-as-a-biomimetic-scaffolding-strategy-for-uniform-bone-tissue-regeneration
#7
Jian Zhang, Jinpeng Jia, Jimin P Kim, Hong Shen, Fei Yang, Qiang Zhang, Meng Xu, Wenzhi Bi, Xing Wang, Jian Yang, Decheng Wu
Inspired by the highly ordered nanostructure of bone, nanodopant composite biomaterials are gaining special attention for their ability to guide bone tissue regeneration through structural and biological cues. However, bone malformation in orthopedic surgery is a lingering issue, partly due to the high surface energy of traditional nanoparticles contributing to aggregation and inhomogeneity. Recently, carboxyl-functionalized synthetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins in stabilizing hydroxyapatite and directing intrafibrillar mineralization in-vitro...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28194875/nanophase-bone-substitute-for-craniofacial-load-bearing-application-pilot-study-in-the-rodent
#8
Jonathan Z Baskin, Yohannes Soenjaya, James McMasters, Alvin Ko, Amit Vasanji, Nathan Morris, Steven J Eppell
An exploratory pilot study shows that a rodent mandibular defect model is useful in determining the biological response to a nanophase collagen/apatite composite designed as a biomimetic load-bearing bone substitute. Using a critical size defect, eight groups of rats (n = 3) were implanted with four renditions of the nanophase bone substitute (NBS) biomaterial. Each rendition was tested with and without recombinant human bone morphogenetic protein 2 (BMP2). NBS biomaterial renditions were: baseline, hyper-densified, d-ribose crosslinked, and d-ribose crosslinked and hyper-densified...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28183675/mechanistic-investigation-on-microbial-toxicity-of-nano-hydroxyapatite-on-implant-associated-pathogens
#9
K Baskar, T Anusuya, G Devanand Venkatasubbu
The use of atomic scale inorganic nanoparticles (NPs) to fight against pathogenic microorganisms is a recent trend in biomedical area which overcomes the limitations of organic compounds in terms of stability, shelf life and bioactivity. One such Calcium phosphate based biomaterial is hydroxyapatite (HA), considered as potential bioactive compound with excellent biocompatibility, osteointegrity and biodegradability. Osteomyelitis, the implant associated infection, is the major problem worldwide responsible for the majority of implant failure cases...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28130134/nanoceramics-on-osteoblast-proliferation-and-differentiation-in-bone-tissue-engineering
#10
REVIEW
Sai Nievethitha S, Subhapradha N, Saravanan D, Selvamurugan N, Wei-Bor Tsai, Srinivasan N, Murugesan R, Moorthi A
Bone, a highly dynamic connective tissue, consist of a bioorganic phase comprising osteogenic cells and proteins which lies over an inorganic phase predominantly made of CaPO4 (biological apatite). Injury to bone can be due to mechanical, metabolic or inflammatory agents also owing pathological conditions like fractures, osteomyelitis, osteolysis or cysts may arise in enameloid, chondroid, cementum, or chondroid bone which forms the intermediate tissues of the body. Bone tissue engineering (BTE) applies bioactive scaffolds, host cells and osteogenic signals for restoring damaged or diseased tissues...
January 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28116421/-experimental-study-of-double-root-implantation-with-the-aid-of-template-in-rabbits
#11
Hai-Yan Xu, Qing Zhang, Li-Hua Fang, Jia You
PURPOSE: To evaluate the feasibility of double-root implantation with the aid of template. METHODS: Implant templates were fabricated based on CT data from the tibia of 12 rabbits. 12 double-root implants were placed in the tibia of rabbits under the guidance of implant templates, and single-root implants were placed in contralateral tibia of the same rabbits. Rabbits were sacrificed at 8 and 12 weeks. Implant mobility was checked directly. Specimens were examined by X-ray to measure bone gray value using Image Pro-Plus6...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28111942/osteogenesis-catalyzed-by-titanium-supported-silver-nanoparticles
#12
Huiliang Cao, Wenjie Zhang, Fanhao Meng, Jinshu Guo, Donghui Wang, Shi Qian, Xinquan Jiang, Xuanyong Liu, Paul K Chu
Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium...
February 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28107234/comparison-between-acrylic-cage-and-polyetheretherketone-peek-cage-in-single-level-anterior-cervical-discectomy-and-fusion-a-randomized-clinical-trial
#13
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28102294/novel-bio-functional-magnesium-coating-on-porous-ti6al4v-orthopaedic-implants-in-vitro-and-in-vivo-study
#14
Xiaokang Li, Peng Gao, Peng Wan, Yifeng Pei, Lei Shi, Bo Fan, Chao Shen, Xin Xiao, Ke Yang, Zheng Guo
Titanium and its alloys with various porous structures are one of the most important metals used in orthopaedic implants due to favourable properties as replacement for hard tissues. However, surface modification is critical to improve the osteointegration of titanium and its alloys. In this study, a bioactive magnesium coating was successfully fabricated on porous Ti6Al4V by means of arc ion plating, which was proved with fine grain size and high film/substrate adhesion. The surface composition and morphology were characterized by X-ray diffraction and SEM equipped with energy dispersive spectroscopy...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28095523/effects-of-titanium-surface-microtopography-and-simvastatin-on-growth-and-osteogenic-differentiation-of-human-mesenchymal-stem-cells-in-estrogen-deprived-cell-culture
#15
Premjit Arpornmaeklong, Prisana Pripatnanont, Chonticha Chookiatsiri, Boonsin Tangtrakulwanich
PURPOSE: This study aimed to investigate the effects of titanium surface topography and simvastatin on growth and osteogenic differentiation of human bone marrow stromal cells (hBMSCs) in estrogen-deprived (ED) cell culture. MATERIALS AND METHODS: Human BMSCs were seeded on cell culture plates, smooth-surface titanium (Ti) disks, and sandblasted with large grits and acid etched (SLA)-surface Ti disks; and subsequently cultured in regular (fetal bovine serum [FBS]), ED, and ED-with 100 nM simvastatin (ED-SIM) culture media for 14 to 21 days...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28094026/nanoporous-hydroxyapatite-sodium-titanate-bilayer-on-titanium-implants-for-improved-osteointegration
#16
A Carradò, F Perrin-Schmitt, Q V Le, M Giraudel, C Fischer, G Koenig, L Jacomine, L Behr, A Chalom, L Fiette, A Morlet, G Pourroy
OBJECTIVE: The aim of this study was to improve the strength and quality of the titanium-hydroxyapatite interface in order to prevent long-term failure of the implanted devices originating from coating delamination and to test it in an in-vivo model. METHODS: Ti disks and dental commercial implants were etched in Kroll solution. Thermochemical treatments of the acid-etched titanium were combined with sol-gel hydroxyapatite (HA) coating processes to obtain a nanoporous hydroxyapatite/sodium titanate bilayer...
March 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28093043/electrospun-yarn-reinforced-nanoha-composite-matrix-as-a-potential-bone-substitute-for-enhanced-regeneration-of-segmental-defects
#17
Anitha A Nair, John Joseph, Deepthy Menon, Shantikumar Nair, Manitha Nair
Nanohydroxyapatite (HA) is a well-established synthetic bone substitute with excellent osteoconduction and osteointegration. However, brittleness coupled with slow degradation curtail its load bearing and bone regeneration potential respectively. To address these limitations, nanoHA composite matrix reinforced with electrospun 1D fibrous yarns was fabricated and tested in vitro and in vivo. Different weight percentages (5, 10, 15 wt%) and varying lengths (short and continuous) of PLLA yarns were randomly dispersed in a gelatinous matrix containing nanoHA...
January 17, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28081293/role-of-pyridoxal-5-phosphate-at-the-titanium-implant-interface-in-vivo-increased-hemophilicity-inactive-platelet-adhesion-and-osteointegration
#18
Jung Seung Lee, Kyuri Kim, Joseph P Park, Seung-Woo Cho, Haeshin Lee
Titanium is the most biocompatible inorganic biomaterial with a long history of use in orthopedic and dental implants. However, promoting rapid and effective bone formation and integration onto etched, rough TiO2 surfaces has been a challenging topic. Here, 21 commercially available molecules are examined that met the following criteria: (1) contain phosphonic acid for stable immobilization onto TiO2 surfaces and (2) have a molecular weight less than 500 Da for negligible coating thickness. Of these molecules, the surface immobilization of pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28060095/virtual-surgery-planning-and-three-dimensional-printing-template-to-customize-bone-graft-toward-implant-insertion
#19
Nathalie Pham Dang, Agathe Lafarge, Arnaud Depeyre, Laurent Devoize, Isabelle Barthélémy
Premaxillary tooth loss and bone deficiency or atrophy often occur in facial trauma. Onlay bone graft and implants have so far been the best means of restoring function and esthetic appearance. Void space between the graft and the jaw bone, over projection and mucosal trauma can cause mucosal dehiscence, bone exposure, or resorption and can compromise implant survival. Virtual surgical planning using 3-dimensional printing technology has improved the efficiency of craniofacial surgery. The drawbacks of this technology are its cost and time-consuming preparation...
March 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28013335/hydroxyapatite-ceramic-implants-for-cranioplasty-in-children-a-single-center-experience
#20
Laura Zaccaria, Sasha Job Tharakan, Stefan Altermatt
PURPOSE: The use of hydroxyapatite ceramic (HAC) implants for the treatment of skull defects in pediatric patients started 2010 at our institution. Ceramic implants facilitate osteoblast migration and therefore optimize osteointegration with the host bone. The purpose of this study is to report a single-center experience with this treatment modality. METHODS: A retrospective review of all patients from July 2010 through June 2014 undergoing a cranioplasty using hydroxyapatite ceramic implant and managed at a single institution was performed...
February 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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