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Osteointegration

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https://www.readbyqxmd.com/read/29231215/involvement-of-fak-mediated-bmp-2-smad-pathway-in-mediating-osteoblast-adhesion-and-differentiation-on-nano-ha-chitosan-composite-coated-titanium-implant-under-diabetic-conditions
#1
Xiang-Yu Ma, Ya-Fei Feng, Tian-Sheng Wang, Wei Lei, Xiang Li, Da-Peng Zhou, Xin-Xin Wen, Hai-Long Yu, Liang-Bi Xiang, Lin Wang
Chitosan (CS)-based hydroxyapatite (HA) composites have emerged as a novel strategy for promoting bone regeneration. Here nanophase HA/CS composite coated porous titanium implants (nCT) were fabricated and their biological behavior under diabetic conditions was investigated. We proposed that the focal adhesion kinase (FAK)-mediated BMP-2/Smad pathway played a role in mediating the promotive effect of nCTs on osteoblast adhesion and differentiation under diabetes-induced high reactive oxygen species (ROS) condition...
December 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29227620/nano-ag-zno-incorporated-hydroxyapatite-composite-coatings-highly-effective-infection-prevention-and-excellent-osteointegration
#2
Yanzhe Zhang, Xiangmei Liu, Zhaoyang Li, Shengli Zhu, Xu-Bo Yuan, Zhenduo Cui, Xianjin Yang, Paul K Chu, Shuilin Wu
The interfacial characterisics play an important role in infection prevention and osteointegration of artificial bone implants. In this work, both Ag and ZnO nanoparticles are incorporated into hydroxyapatite (HA) nano powders and deposited onto Ti6Al4V (Ti6) implants by laser cladding. The composite coatings possess a hierarchical surface structure with homogeneous distributions of Ag and ZnO. The Ag and ZnO nanoprticles are immobilized by laser cladding ensure long-term and gradual release of Ag and Zn ions at low cumulative concentrations of 36...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29221842/comparison-of-an-uncemented-tapered-stem-design-in-cobalt-chrome-vs-titanium-at-15-year-follow-up
#3
Ricardo Fernández-Fernández, Jesus M Martínez-Miranda, Enrique Gil-Garay
BACKGROUND: Cobalt-chromium (Co-Cr) and titanium (Ti) have been the most popular materials employed for cementless implants. The purpose of this study was to compare clinical and radiological results of a single stem design with both alloys at long-term follow-up. METHODS: Two hundred consecutive uncemented stems implanted in 171 patients (100 Co-Cr and 100 Ti implants) between 1999 and 2002 were studied. Mean age of the patients was 60.9 years (range, 20-84). Clinical results were evaluated using the Harris hip score...
November 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29205768/the-applications-of-regenerative-medicine-in-sinus-lift-procedures-a-systematic-review
#4
REVIEW
Francisco Correia, Daniel Humberto Pozza, Sónia Gouveia, António Felino, Ricardo Faria E Almeida
BACKGROUND: Findings in regenerative medicine applied to the sinus lift procedures. PURPOSE: Evaluate the effectiveness of regenerative medicine in sinus lift. MATERIALS AND METHODS: An extensive search for manuscripts were performed by using different combinations of keywords and MeSH terms (Pub-med; Embase; Scopus; Web of Science Core Collection; Medline; Current Contents Connect; Derwent Innovations Index; Scielo Citation Index; Cochrane library)...
December 3, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29198812/the-effect-of-a-radial-neck-notch-on-press-fit-stem-stability-a-biomechanical-study-on-7-cadavers
#5
Dave R Shukla, Dipit C Sahu, James S Fitzsimmons, Kai-Nan An, Shawn W O'Driscoll
BACKGROUND: Minimal micromotion is necessary for osteointegration of cementless radial head prostheses. When radial head fractures extend longitudinally, where the neck cut for prosthetic replacement should be made is uncertain. We hypothesized that complete resection of the notched portion of a radial neck confers no advantage in initial stability compared with not resecting the defect and inserting the implant into a notched radial neck. MATERIALS AND METHODS: The radii of 7 cadavers underwent radial head resection and implantation with a 25-mm-long press-fit radial head stem...
November 29, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29164531/biphasic-bioresorbable-scaffold-trufit-%C3%A2-in-knee-osteochondral-defects-3-t-mri-evaluation-of-osteointegration-in-patients-with-a-5-year-minimum-follow-up
#6
G Bugelli, F Ascione, G Dell'Osso, V Zampa, S Giannotti
PURPOSE: The aim of this study is to follow morphological imaging characteristics and osteointegration of TruFit(®) bone graft substitute (BGS) plugs in cases of chondral and osteochondral defects of the articular surface of the knee joint, using high-quality cartilage-sensitive 3-T magnetic resonance imaging (MRI), linked to clinical outcomes. METHODS: The MRI was used to assess osteointegration and biological evolution of the TruFit(®) BGS plugs in cases with minimum 5-year follow-up: The TruFit(®) plug was used in 46 patients for a total of 47 cases with mean age of 57...
November 21, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29153382/a-pilot-study-alternative-biomaterials-in-critical-sized-bone-defect-treatment
#7
Magdalena Tarchala, Victor Engel, Jake Barralet, Edward J Harvey
BACKGROUND: Critical-sized bone defects are a significant challenge with limited effective reconstructive options. The Masquelet Technique (MT) offers a solution to help restore form and function. Although this technique has produced promising results; a clear mechanism has not been determined. Theories include that the induced membrane has osteogenic potential or the membrane acts as a physical barrier to prevent fibrous tissue ingrowth. We hypothesize the induced membrane acts primarily as a physical barrier and that a synthetic non-biological membrane will allow a comparable amount of bone volume in the defect site...
November 9, 2017: Injury
https://www.readbyqxmd.com/read/29149388/problems-of-reconstructive-cranioplasty-after-traumatic-brain-injury-in-children
#8
Paolo Frassanito, Gianpiero Tamburrini, Luca Massimi, Simone Peraio, Massimo Caldarelli, Concezio Di Rocco
Cranial repair after traumatic brain injury in children is still burdened by unsolved problems and controversial issues, mainly due to the high rate of resorption of autologous bone as well as the absence of valid alternative material to replace the autologous bone. Indeed, inert biomaterials are associated to satisfactory results in the short period but bear the continuous risk of complications related to the lack of osteointegration capacity. Biomimetic materials claiming osteoconductive properties that could balance their mechanical limits seem to allow good cranial bone reconstruction...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149082/the-biological-properties-of-ogi-surfaces-positively-act-on-osteogenic-and-angiogenic-commitment-of-mesenchymal-stem-cells
#9
Paolo Ghensi, Eriberto Bressan, Chiara Gardin, Letizia Ferroni, Maria Costanza Soldini, Federico Mandelli, Claudio Soldini, Barbara Zavan
Osteogenesis process displays a fundamental role during dental implant osteointegration. In the present work, we studied the influence of Osteon Growth Induction (OGI) surface properties on the angiogenic and osteogenic behaviors of Mesenchymal Stem cells (MSC). MSC derived from dental pulp and HUVEC (Human Umbilical Vein Endothelial Cells) were grown in on OGI titanium surfaces, and cell proliferation and DNA synthesis were evaluated by MTT [3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide] test and DNA quantification...
November 17, 2017: Materials
https://www.readbyqxmd.com/read/29137166/antimicrobial-and-osseointegration-properties-of-nanostructured-titanium-orthopaedic-implants
#10
REVIEW
Marcus Jäger, Herbert P Jennissen, Florian Dittrich, Alfons Fischer, Hedda Luise Köhling
The surface design of titanium implants influences not only the local biological reactions but also affects at least the clinical result in orthopaedic application. During the last decades, strong efforts have been made to improve osteointegration and prevent bacterial adhesion to these surfaces. Following the rule of "smaller, faster, cheaper", nanotechnology has encountered clinical application. It is evident that the hierarchical implant surface micro- and nanotopography orchestrate the biological cascades of early peri-implant endosseous healing or implant loosening...
November 13, 2017: Materials
https://www.readbyqxmd.com/read/29103060/use-of-antibiotic-impregnated-bone-grafts-in-a-rabbit-osteomyelitis-model
#11
Akos Zahar, György Kocsis, Mustafa Citak, Gábor Puskás, Mónika Domahidy, Mária Hajdú, István Antal, Miklós Szendrői
BACKGROUND: Both osteomyelitis and prosthetic joint infection can be treated surgically with the use of antibiotic loaded bone grafts, as part of local antimicrobial therapy. OBJECTIVE: The purpose of the study was to evaluate and to report on a novel, biodegradable, long-acting (4-6 weeks) antibiotic-impregnated bone graft (AIBG). A novel drug delivery system, containing vancomycin, was utilized in a rabbit osteomyelitis model in order to evaluate the antimicrobial efficacy of the antibiotic bone graft...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29083348/cementless-knee-arthroplasty
#12
Lorenzo Ponziani, Francesco Di Caprio, Renato Meringolo
Total knee replacement is a common treatment for advanced knee osteoarthritis. The most common and widespread method is cemented arthroplasty. As in the prosthetic hip a gradual transition from cemented to uncemented fixation techniques occurred over time, increasing interest is growing also around cementless knee fixation, with the theoretical advantages of preserving the bone stock and obtaining a biological fixation avoiding cement fragmentation. On the basis of the actual knowledge, the uncemented knee prosthesis represents an interesting alternative especially for the patient under 65 years of age, with viable bone quality, in which a biological bone-prosthesis fixation is desirable, while avoiding the drawbacks of cement fragmentation and of the possible future revision of a cemented implant...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29068320/osteogenic-effects-of-simvastatin-loaded-mesoporous-titania-thin-films
#13
Miriam Lopez-Alvarez, Vanesa López-Puente, Cosme Rodriguez-Valencia, Paula C Angelomé, Luis M Liz-Marzan, Julia Serra, Isabel Pastoriza-Santos, Pio Gonzalez
The use of statins in the field of bone regeneration is under current investigation due to the existing demand for non-toxic anabolic agents capable of enhancing bone formation in cases of substantial loss. Simvastatin, a coenzyme currently prescribed in clinics to inhibit cholesterol biosynthesis, has been proven to promote osteogenic differentiation by stimulating bone formation and inhibiting osteoclasts activity. We present the loading of simvastatin in mesoporous TiO2 thin films toward combining the pro-osteogenic properties of this molecule with the demonstrated bioactivity of titania...
October 25, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29066107/clinical-and-radiographic-outcomes-at-25-30-years-of-a-hip-stem-fully-coated-with-hydroxylapatite
#14
Laurent Jacquot, Michel P Bonnin, Alain Machenaud, Julien Chouteau, Mo Saffarini, Jean-Pierre Vidalain
BACKGROUND: Little is known about the survival of total hip arthroplasty implants with bioactive coatings beyond the first 20 years. The authors aimed to report survival of a tapered hip stem fully coated with hydroxylapatite (HA) at follow-up of 25-30 years. METHODS: Of the original series of 320 patients (347 hips), 12 patients (12 hips) had stem and cup revisions, 54 patients (55 hips) had cup revisions, 17 patients (17 hips) had liner exchange. A total of 207 patients (225 hips) died with stems in place and 21 patients (24 hips) could not be reached...
September 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29063963/does-oxidative-stress-play-a-role-in-altered-characteristics-of-diabetic-bone-a-systematic-review
#15
REVIEW
Miljana Bacevic, Bozidar Brkovic, Adelin Albert, Eric Rompen, Regis P Radermecker, France Lambert
Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected...
December 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29049874/balancing-bacteria-osteoblast-competition-through-selective-physical-puncture-and-biofunctionalization-of-zno-polydopamine-arginine-glycine-aspartic-acid-cysteine-nanorods
#16
Jun Li, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Bacterial infection and lack of bone tissue integration are two major concerns of orthopedic implants. In addition, osteoinductivity often decreases and toxicity may arise when antibacterial agents are introduced to increase the antibacterial ability. Here hybrid ZnO/polydopamine (PDA)/arginine-glycine-aspartic acid-cysteine (RGDC) nanorod (NR) arrays are designed and prepared on titanium (Ti) implants to not only enhance the osteoinductivity but also effectively kill bacteria simultaneously, which are ascribed to the selective physical puncture and the biofunctionalization of ZnO/PDA/RGDC nanorods during the competition between bacteria and osteoblasts...
October 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/29021589/enhanced-cell-attachment-and-hemocompatibility-of-titanium-by-nanoscale-surface-modification-through-severe-plastic-integration-of-magnesium-rich-islands-and-porosification
#17
Masoud Rezaei, Elnaz Tamjid, Ali Dinari
Besides the wide applications of titanium and its alloys for orthopedic and biomedical implants, the biocompatible nature of titanium has emerged various surface modification techniques to enhance its bioactivity and osteointegration with living tissues. In this work, we present a new procedure for nanoscale surface modification of titanium implants by integration of magnesium-rich islands combined with controlled formation of pores and refinement of the surface grain structure. Through severe plastic deformation of the titanium surface with fine magnesium hydride powder, Mg-rich islands with varying sizes ranging from 100 nm to 1000 nm can be integrated inside a thin surface layer (100-500 µm) of the implant...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986950/modeling-of-the-interaction-between-osteoblasts-and-biocompatible-substrates-as-a-function-of-adhesion-strength
#18
D V Portan, D D Deligianni, K Deligianni, A A Kroustalli, M Tyllianakis, G C Papanicolaou
A goal of current implantology research is to design devices that induce controlled, guided, and rapid healing. Nano-scale structured substrates (e.g. titania nanotubes - TNTs or carbon nanotubes - CNTs) dramatically improve the functions of conventional biomaterials. The present investigation evaluated the behavior of osteoblasts cells cultured on smooth and nanostructured substrates, by measuring osteoblasts specific biomarkers (alkaline phosphatase and total protein) and cells adhesion strength to substrates, followed by semi-empirical modeling to predict the experimental results...
October 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28970533/enhancing-cell-proliferation-and-osteogenic-differentiation-of-mc3t3-e1-pre-osteoblasts-by-bmp-2-delivery-in-graphene-oxide-incorporated-plga-ha-biodegradable-microcarriers
#19
Chuan Fu, Xiaoyu Yang, Shulian Tan, Liangsong Song
Lack of bioactivity has seriously restricted the development of biodegradable implants for bone tissue engineering. Therefore, surface modification of the composite is crucial to improve the osteointegration for bone regeneration. Bone morphogenetic protein-2 (BMP-2), a key factor in inducing osteogenesis and promoting bone regeneration, has been widely used in various clinical therapeutic trials. In this study, BMP-2 was successfully immobilized on graphene oxide-incorporated PLGA/HA (GO-PLGA/HA) biodegradable microcarriers...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963015/human-osteoblasts-grow-transitional-si-n-apatite-in-quickly-osteointegrated-si3n4-cervical-insert
#20
Giuseppe Pezzotti, Naoki Oba, Wenliang Zhu, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Bryan McEntire, Kengo Yamamoto, B Sonny Bal
Silicon nitride (Si3N4) ceramics possesses surface chemistry that accelerates bone repair, as previously established by in vitro experiments using both osteosarcoma and mesenchymal cells. The release of silicic acid and nitrogen compounds from the surface Si3N4 enhanced in vitro cellular activity. The results of this study demonstrate for the first time that the osseointegration behavior previously observed is operative with a peculiar chemistry within the human milieu. Si and N elements stimulated progenitor cell differentiation and osteoblastic activity, which ultimately resulted in accelerated bone ingrowth...
December 2017: Acta Biomaterialia
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