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Osteointegration

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https://www.readbyqxmd.com/read/28798870/histopathological-and-imageological-studies-on-clinical-outcomes-of-mineralized-collagen-reconstruction-rod-for-femoral-head-necrosis-with-one-case-report
#1
Baogang Xie, Hao Wang, Jianhua Hao, Ping Wang, Na Zhang, Jingjing Wu, Zhiye Qiu, Fuzhai Cui
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head, interface between the host bone and implant and the bone reconstruction process. The results showed that the density of rods increased closed to that of host bones after 1 year implanting, and the interface between them turns to blurring...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28793006/osteointegration-of-porous-absorbable-bone-substitutes-a-systematic-review-of-the-literature
#2
Maria Júlia Escanhoela Paulo, Mariana Avelino Dos Santos, Bruno Cimatti, Nelson Fabrício Gava, Marcelo Riberto, Edgard Eduard Engel
Biomaterials' structural characteristics and the addition of osteoinductors influence the osteointegration capacity of bone substitutes. This study aims to identify the characteristics of porous and resorbable bone substitutes that influence new bone formation. An Internet search for studies reporting new bone formation rates in bone defects filled with porous and resorbable substitutes was performed in duplicate using the PubMed, Web of Science, Scielo, and University of São Paulo Digital Library databases...
July 2017: Clinics
https://www.readbyqxmd.com/read/28783082/incorporation-of-collagen-in-calcium-phosphate-cements-for-controlling-osseointegration
#3
Ming-Hsien Hu, Pei-Yuan Lee, Wen-Cheng Chen, Jin-Jia Hu
In this study, we investigated the effect of supplementing a non-dispersive dicalcium phosphate-rich calcium phosphate bone cement (DCP-rich CPC) with type I collagen on in vitro cellular activities and its performance as a bone graft material. Varying amounts of type I collagen were added during the preparation of the DCP-rich CPC. In vitro cell adhesion, morphology, viability, and alkaline phosphatase (ALP) activity were evaluated using progenitor bone cells. Bone graft performance was evaluated via a rat posterolateral lumbar fusion model and osteointegration of the implant...
August 6, 2017: Materials
https://www.readbyqxmd.com/read/28773906/novel-resorbable-and-osteoconductive-calcium-silicophosphate-scaffold-induced-bone-formation
#4
Patricia Ros-Tárraga, Patricia Mazón, Miguel A Rodríguez, Luis Meseguer-Olmo, Piedad N De Aza
This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5-1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material's interior...
September 20, 2016: Materials
https://www.readbyqxmd.com/read/28773884/novel-osteointegrative-sr-substituted-apatitic-cements-enriched-with-alginate
#5
Simone Sprio, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Wanda Lattanzi, Enrico Pola, Giandomenico Logroscino, Anna Tampieri
The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration...
September 8, 2016: Materials
https://www.readbyqxmd.com/read/28765800/fortifying-the-bone-implant-interface-part-2-an-in-vivo-evaluation-of-3d-printed-and-tps-coated-triangular-implants
#6
Regina F MacBarb, Derek P Lindsey, Shane A Woods, Peggy A Lalor, Mukund I Gundanna, Scott A Yerby
BACKGROUND: Minimally invasive surgical fusion of the sacroiliac (SI) joint using machined solid triangular titanium plasma spray (TPS) coated implants has demonstrated positive clinical outcomes in SI joint pain patients. Additive manufactured (AM), i.e. 3D-printed, fenestrated triangular titanium implants with porous surfaces and bioactive agents, such as nanocrystalline hydroxyapatite (HA) or autograft, may further optimize bony fixation and subsequent biomechanical stability. METHODS: A bilateral ovine distal femoral defect model was used to evaluate the cancellous bone-implant interfaces of TPS-coated and AM implants...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28757936/three-point-bending-test-simulation-on-implant-fpds-with-a-bio-faithful-model
#7
V Vertucci, M Montani, C Arcuri, P Cardelli
AIM OF THE STUDY: It is well known by previous important studies that mandible flexes during different jaw movements. According to this assumption it is very important to know how implant supported fixed partial dentures could restrict mandibular movements and, could lead to excess strain accumulation that could modify the resolution of implant treatment. The aim of our project is to create a bio-faithful model able to recreate mandibular movements, during three point bending test methods of (FIXED -PARTIAL -DENTURES) FPDs, to avoid a not flexible metal base, where models' properties doesn't allow to obtain a bio-faithful simulation during testing phases...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28753275/osteoconductive-amine-functionalized-graphene-poly-methylmethacrylate-bone-cement-composite-with-controlled-exothermic-polymerization
#8
Rakesh Sharma, Govinda Kapusetti, Sayali Y Bhong, Partha Roy, Santosh Kumar Singh, Shikha Singh, Biswajit Ray, Pralay Maiti, Nira Misra
Bone cement finds its extensive usage in joint arthroplasty since last 50 years, still, the development of bone cement with essential properties like high fatigue resistance, lower exothermic temperature, and bioactivity has been an unsolved problem. In our present work, we have addressed all the mentioned shortcomings of bone cement by reinforcing it with graphene (GR), graphene oxide (GO) and surface modified amino graphene (AG) fillers. These nanocomposites have shown hypsochromic shifts suggesting strong interactions between the filler material and the polymer matrix...
July 28, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28739150/plasma-assisted-surface-treatments-of-biomaterials
#9
L Minati, C Migliaresi, L Lunelli, G Viero, M Dalla Serra, G Speranza
The biocompatibility of an implant depends upon the material it is composed of, in addition to the prosthetic device's morphology, mechanical and surface properties. Properties as porosity and pore size should allow, when required, cells penetration and proliferation. Stiffness and strength, that depend on the bulk characteristics of the material, should match the mechanical requirements of the prosthetic applications. Surface properties should allow integration in the surrounding tissues by activating proper communication pathways with the surrounding cells...
July 12, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28735526/the-biocompatibility-of-bone-cements-progress-in-methodological-approach
#10
Carlo Dall'Oca, Tommaso Maluta, Gian Mario Micheloni, Matteo Cengarle, Giampaolo Morbioli, Paolo Bernardi, Andrea Sbarbati, Daniele Degl'Innocenti, Franco Lavini, Bruno Magnan
The ideal bone graft substitute should have certain properties and there are many studies dealing with mixture of polymethylmetacrilate (PMMA) and β-tricalciumphospate (β-TCP) presenting the best characteristics of both. Scanning Electron Microscopy (SEM), for ultra-structural data, resulted a very reliable in vivo model to better understand the bioactivity of a cement and to properly evaluate its suitability for a particular purpose. The present study aims to further improve the knowledge on osteointegration development, using both parameters obtained with the Environmental Scanning Electron Microscopy (ESEM) and focused histological examination...
May 4, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28709036/hydroxyapatite-and-bioactive-glass-surfaces-for-fiber-reinforced-composite-implants-via-surface-ablation-by-excimer-laser
#11
Julia Kulkova, Niko Moritz, Hannu Huhtinen, Riina Mattila, Ivan Donati, Eleonora Marsich, Sergio Paoletti, Pekka K Vallittu
In skeletal reconstructions, composites, such as bisphenol-A-glycidyldimethacrylate resin reinforced with glass fibers, are potentially useful alternatives to metallic implants. Recently, we reported a novel method to prepare bioactive surfaces for these composites. Surface etching by Excimer laser was used to expose bioactive glass granules embedded in the resin. The purpose of this study was to analyze two types of bioactive surfaces created by this technique. The surfaces contained bioactive glass and hydroxyapatite granules...
July 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28697864/porous-coated-metaphyseal-sleeves-for-severe-femoral-and-tibial-bone-loss-in-revision-tka
#12
Tyler S Watters, John R Martin, Daniel L Levy, Charlie C Yang, Raymond H Kim, Douglas A Dennis
BACKGROUND: Metaphyseal bone loss is commonly encountered in revision total knee arthroplasty (TKA). Anderson Orthopaedic Research Institute types 2 and 3 defects generally require some form of metaphyseal fixation or augmentation. This study evaluates the midterm results of stepped, porous-coated metaphyseal sleeves in revision TKA in the setting of severe bone loss. METHODS: Patients who underwent revision TKA using metaphyseal sleeves from March 2006 to May 2014 at our institution were identified from a prospective research database...
June 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28688825/three-dimensional-bio-printed-scaffold-sleeves-with-mesenchymal-stem-cells-for-enhancement-of-tendon-to-bone-healing-in-anterior-cruciate-ligament-reconstruction-using-soft-tissue-tendon-graft
#13
Sin Hyung Park, Yeong-Jin Choi, Sang Won Moon, Byung Hoon Lee, Jin-Hyung Shim, Dong-Woo Cho, Joon Ho Wang
PURPOSE: To investigate the efficacy of the insertion of 3-dimensional (3D) bio-printed scaffold sleeves seeded with mesenchymal stem cells (MSCs) to enhance osteointegration between the tendon and tunnel bone in anterior cruciate ligament (ACL) reconstruction in a rabbit model. METHODS: Scaffold sleeves were fabricated by 3D bio-printing. Before ACL reconstruction, MSCs were seeded into the scaffold sleeves. ACL reconstruction with hamstring tendon was performed on both legs of 15 adult rabbits (aged 12 weeks)...
July 5, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28677938/alveolar-splitting-with-piezosurgery-bone-bank-grafts-and-nobelactive-implants-as-an-alternative-to-major-bone-grafting-for-maxillary-reconstruction
#14
Massimo Albanese, Giulia Ricciardi, Dario Donadello, Alessandra Lucchese, Federico Gelpi, Alessandro Zangani, Daniele DE Santis, Alessandro Rizzini, Alberto Rossetto, Dario Bertossi
BACKGROUND: Piezo-surgery represents a novel alternative technique. The Piezo-surgery is well tolerated and permits a large number of applications in decribed literature. The principle of piezo-surgery consists into inducing micro-vibrations to a metallic insert with a particular custom. The aim of this article is to study and to evaluate the use of Nobelactive implants in combination with piezosurgical split-crest technique in severe atrophy of the upper maxilla. This approach allows avoiding the use of onlay grafts, due to rise the trasversal width of the crestal bone, which could have more complications and uncertain prognosis...
July 4, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28665112/nacre-topography-produces-higher-crystallinity-in-bone-than-chemically-induced-osteogenesis
#15
Enateri V Alakpa, Karl E V Burgess, Peter Chung, Mathis O Riehle, Nikolaj Gadegaard, Matthew John Dalby, Maggie Cusack
It is counterintuitive that invertebrate shells can induce bone formation, yet nacre, or mother of pearl, from marine shells is both osteoinductive and osteointegrative. Nacre is composed of aragonite (calcium carbonate) and induces production of vertebrate bone (calcium phosphate). Exploited by the Mayans for dental implants, this remarkable phenomenon has been confirmed in vitro and in vivo, yet the characteristic of nacre that induces bone formation remains unknown. By isolating nacre topography from its inherent chemistry in the production of polycaprolactone (PCL) nacre replica, we show that, for mesenchymal stem cells, nacre topography is osteoinductive...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28650136/platform-switching-and-super-short-implants-an-effective-technique-to-manage-residual-jaws-bone-volume
#16
Graziano Montaruli, Michele Laurenziello, Lucio Lo Russo, Luigi Laino, Lorenzo Lo Muzio, Domenico Ciavarella
INTRODUCTION: Authors describe and analyze an implant-prosthetic rehabilitation of posterior partially edentulous jaw by using a super-short implant, according to the platform switching technique, on which a lithium disilicate made crown was cemented. METHODS: One event of partially edentulous jaw in 2.6 region needing implant-prosthetic rehabilitationwas selected for this treatment. Because of the lack of vertical bone, a super-short implant (6mm in diameter and 6mm in length) has been placed according to the platform switching technique by using surgical and prosthetic components lower in diameter compared to the diameter of the implant's platform...
June 23, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28624657/adiponectin-improves-the-osteointegration-of-titanium-implant-under-diabetic-conditions-by-reversing-mitochondrial-dysfunction-via-the-ampk-pathway-in-vivo-and-in-vitro
#17
Xiao-Fan Hu, Lin Wang, Yi-Zhao Lu, Geng Xiang, Zi-Xiang Wu, Ya-Bo Yan, Yang Zhang, Xiong Zhao, Yuan Zang, Lei Shi, Wei Lei, Ya-Fei Feng
Diabetes-induced reactive oxygen species (ROS) overproduction would result in compromised osteointegration of titanium implant (TI) and high rate of implant failure, yet the underlying mechanisms remain elusive. Adiponectin (APN) is a fat-derived adipocytokine with strong antioxidant, mitochondrial-protective and anti-diabetic efficacies. We hypothesized that mitochondrial dysfunction under diabetes may account for the oxidative stress in osteoblasts and titanium-bone interface (TBI) instability, which could be ameliorated by APN...
June 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28619648/biophysical-characterization-of-nanostructured-tio2-as-a-good-substrate-for-hbm-msc-adhesion-growth-and-differentiation
#18
L Petecchia, C Usai, M Vassalli, P Gavazzo
Mesenchymal stem cells from human bone marrow (hBM-MSC) are widely utilized for clinical applications involving bone healing. In this context, their use has been often optimized in association to variously designed titanium substrates, being this material of great use in orthopaedic implants. According to recent findings, the ability of hBM-MSC to differentiate towards a specific lineage is not only driven by biochemical signals, but physical stimuli, such as rigidity or roughness of the substrate, can also support a commitment towards osteogenic differentiation...
June 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28615491/enhanced-osteointegration-of-poly-methylmethacrylate-bone-cements-by-incorporating-strontium-containing-borate-bioactive-glass
#19
Xu Cui, Chengcheng Huang, Meng Zhang, Changshun Ruan, Songlin Peng, Li Li, Wenlong Liu, Ting Wang, Bing Li, Wenhai Huang, Mohamed N Rahaman, William W Lu, Haobo Pan
Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28613059/-experimental-study-of-transforming-growth-factor-%C3%AE-3-combined-with-dental-pulp-stem-cells-in-promoting-the-implant-s-osseointegration
#20
T Wang, Huojia Muhetaer, J Li
Objective: To investigate the effect of transforming growth factor-β3 (TGF-β3) and dental pulp stem cells (DPSC) in promoting the implant's osteointegration. Methods: Thirty-three New Zealand white rabbits were randomly divided into phosphate buffer saline (PBS) group, DPSC group and TGF-β3 + DPSC group (12 rabbits/group). Two teeth from the rabbits's mandibular incisors or molars were pulled out randomly, then implant were placed in the tooth extraction site immediately. In PBS group, the implant area was filled with Bio-Oss powder 0...
June 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
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