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Osteointegration

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https://www.readbyqxmd.com/read/29021589/enhanced-cell-attachment-and-hemocompatibility-of-titanium-by-nanoscale-surface-modification-through-severe-plastic-integration-of-magnesium-rich-islands-and-porosification
#1
Masoud Rezaei, Elnaz Tamjid, Ali Dinari
Besides the wide applications of titanium and its alloys for orthopedic and biomedical implants, the biocompatible nature of titanium has emerged various surface modification techniques to enhance its bioactivity and osteointegration with living tissues. In this work, we present a new procedure for nanoscale surface modification of titanium implants by integration of magnesium-rich islands combined with controlled formation of pores and refinement of the surface grain structure. Through severe plastic deformation of the titanium surface with fine magnesium hydride powder, Mg-rich islands with varying sizes ranging from 100 nm to 1000 nm can be integrated inside a thin surface layer (100-500 µm) of the implant...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986950/modeling-of-the-interaction-between-osteoblasts-and-biocompatible-substrates-as-a-function-of-adhesion-strength
#2
D V Portan, D D Deligianni, K Deligianni, A A Kroustalli, M Tyllianakis, G C Papanicolaou
A goal of current implantology research is to design devices that induce controlled, guided, and rapid healing. Nano-scale structured substrates (e.g. titania nanotubes - TNTs or carbon nanotubes - CNTs) dramatically improve the functions of conventional biomaterials. The present investigation evaluated the behavior of osteoblasts cells cultured on smooth and nanostructured substrates, by measuring osteoblasts specific biomarkers (alkaline phosphatase and total protein) and cells adhesion strength to substrates, followed by semi-empirical modeling to predict the experimental results...
October 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28970533/enhancing-cell-proliferation-and-osteogenic-differentiation-of-mc3t3-e1-pre-osteoblasts-by-bmp-2-delivery-in-graphene-oxide-incorporated-plga-ha-biodegradable-microcarriers
#3
Chuan Fu, Xiaoyu Yang, Shulian Tan, Liangsong Song
Lack of bioactivity has seriously restricted the development of biodegradable implants for bone tissue engineering. Therefore, surface modification of the composite is crucial to improve the osteointegration for bone regeneration. Bone morphogenetic protein-2 (BMP-2), a key factor in inducing osteogenesis and promoting bone regeneration, has been widely used in various clinical therapeutic trials. In this study, BMP-2 was successfully immobilized on graphene oxide-incorporated PLGA/HA (GO-PLGA/HA) biodegradable microcarriers...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963015/human-osteoblasts-grow-transitional-si-n-apatite-in-quickly-osteointegrated-si3n4-cervical-insert
#4
Giuseppe Pezzotti, Naoki Oba, Wenliang Zhu, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Bryan McEntire, Kengo Yamamoto, B Sonny Bal
Silicon nitride (Si3N4) ceramics possesses surface chemistry that accelerates bone repair, as previously established by in vitro experiments using both osteosarcoma and mesenchymal cells. The release of silicic acid and nitrogen compounds from the surface Si3N4 enhanced in vitro cellular activity. The results of this study demonstrate for the first time that the osseointegration behavior previously observed is operative with a peculiar chemistry within the human milieu. Si and N elements stimulated progenitor cell differentiation and osteoblastic activity, which ultimately resulted in accelerated bone ingrowth...
September 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28941652/silk-scaffolds-in-bone-tissue-engineering-an-overview
#5
REVIEW
Promita Bhattacharjee, Banani Kundu, Deboki Naskar, Hae-Won Kim, Tapas K Maiti, Debasis Bhattacharya, Subhas C Kundu
Bone tissue plays multiple roles in our day-to-day functionality. The frequency of accidental bone damage and disorder is increasing worldwide. Moreover, as the world population continues to grow, the percentage of the elderly population continues to grow, which results in an increased number of bone degenerative diseases. This increased elderly population pushes the need for artificial bone implants that specifically employ biocompatible materials. A vast body of literature is available on the use of silk in bone tissue engineering...
September 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28933329/-mid-term-to-long-term-results-of-revision-total-hip-arthroplasty-using-the-oval-shaped-acetabular-cup-tc-type
#6
E Šťastný, T Trč, J Frýdl, Z Kopečný, T Philippou, J Lisý
INTRODUCTION The purpose of our paper is to evaluate the mid-term to long-term results and to confirm the basic criteria of a high-quality revision implant: safe bridging of bone defects, achievement of reliable primary fixation of revision acetabular cup, achievement of good secondary stability with documentable osteointegration of cup and demonstration of remodelling of transplanted bone tissue in the area of defects and in spaces between the implant ribs. MATERIAL AND METHODS Altogether 36 patients (38 cups) were evaluated who had undergone revision hip arthroplasty in the period from 2004 to 2010...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28923538/three-dimensional-nano-architected-scaffolds-with-tunable-stiffness-for-efficient-bone-tissue-growth
#7
Alessandro Maggi, Hanqing Li, Julia R Greer
The precise mechanisms that lead to orthopedic implant failure are not well understood; it is believed that the micromechanical environment at the bone-implant interface regulates structural stability of an implant. In this work, we seek to understand how the 3D mechanical environment of an implant affects bone formation during early osteointegration. We employed two-photon lithography (TPL) direct laser writing to fabricate 3-dimensional rigid polymer scaffolds with tetrakaidecahedral periodic geometry, herewith referred to as nanolattices, whose strut dimensions were on the same order as osteoblasts' focal adhesions (∼2μm) and pore sizes on the order of cell size, ∼10μm...
September 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28919510/magnesium-mg-based-interference-screws-developed-for-promoting-tendon-graft-incorporation-in-bone-tunnel-in-rabbits
#8
Jiali Wang, Jiankun Xu, Bin Song, Dick Hokiu Chow, Patrick Shu-Hang Yung, Ling Qin
How to enhance tendon graft incorporation into bone tunnels for achieving satisfactory healing outcomes in patients with anterior cruciate ligament reconstruction (ACLR) is one of the most challenging clinical problems in orthopaedic sports medicine. Several studies have recently reported the beneficial effects of Mg implants in bone fracture healing, indicating the use potential of Mg devices in promoting the tendon graft osteointegration. Here, we developed an innovative Mg-based interference screws for fixation of the tendon graft in rabbits underwent ACLR and investigated the biological role of Mg-based implants in the graft healing...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28918664/outcomes-of-surface-replacement-proximal-interphalangeal-joint-arthroplasty-using-the-self-locking-finger-joint-implant-minimum-two-years-follow-up
#9
Issei Komatsu, Yoshiya Arishima, Hirotomo Shibahashi, Toshihito Yamaguchi, Yoshitaka Minamikawa
BACKGROUND: The Self Locking Finger Joint (SLFJ) implant is a new type of surface replacement implant. The purpose of this study was to evaluate midterm clinical outcomes of the proximal interphalangeal (PIP) arthroplasty with the SLFJ implant. METHODS: We retrospectively studied 26 PIP joint arthroplasties using the SLFJ implant in 17 patients with osteoarthritis or posttraumatic osteoarthritis. Preoperative and postoperative range of motion, grip strength and key pinch, radiographic findings, and complications were evaluated...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28917605/outcomes-using-wedge-stem-with-full-hydroxiapatite-coverage-with-a-minimum-of-5-years-follow-up
#10
D Godoy-Monzon, M Buttaro, F Comba, G Zanotti, F Piccaluga, I Neira-Borrajo
INTRODUCTION: Total Hip Arthroplsty (THA) using uncemented stems is a popular practice in the last decades. The implant survivorship is crtitical and a less than 10% revision at 10 years is been propesed for commercialization and use. OBJECTIVE: To analyse the clinicoradiological results of an uncemented hydroxiapatite covered wedge stem with a 5 years minimum follow up. MATERIAL AND METHODS: Prospective study, patients aged from 21-75years were included...
September 13, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28917431/results-of-toccata-%C3%A2-resurfacing-pip-joint-arthroplasty-a-series-of-32%C3%A2-cases-at-a-mean-follow-up-of-5-9%C3%A2-years
#11
W Kim, B Renaud, P Dumontier, J-L Condamine
The objective of this study was to evaluate the long-term results of proximal interphalangeal (PIP) resurfacing arthroplasty for treating osteoarthritis: the PIP Toccata implant(®). This was a retrospective study of 32 out of 33 PIP arthroplasty cases performed with a dorsolateral or a Chamay approach by two surgeons after a minimum follow-up of 24 months. Patients were reviewed using a standardized assessment of pain, function, mobility and radiological changes. The average follow-up was 5.9 years. The mean active range of motion was 67° (15-95)...
September 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28910556/probing-the-influence-of-sibling-proteins-on-collagen-i-fibrillogenesis-and-denaturation
#12
Chengyu Jiang, Kevin Zurick, Chunlin Qin, Matthew T Bernards
Bone tissue is comprised of collagen, non-collagenous proteins, and hydroxyapatite and the SIBLING (small integrin binding, N-linked glycoprotein) family of proteins is the primary group of non-collagenous proteins. By replicating the native interactions between collagen and the SIBLING family of proteins at the interface of an implant, it is believed that a bone scaffold will more easily integrate with the surrounding tissue. In this work bone sialoprotein (BSP), osteopontin (OPN), dentin sialoprotein (DSP), dentin phosphoprotein (DPP), C-terminal fragment of dentin matrix protein 1 (DMP1-C) and proteoglycan versions of DSP (DSP-PG) and DMP1 (DMP1-PG) were tested individually to determine their roles in collagen fibrillogenesis and the prevention of denaturation...
September 14, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28861193/comparison-of-poly-l-lactic-acid-and-poly-l-lactic-acid-hydroxyapatite-bioabsorbable-screws-for-tibial-fixation-in-acl-reconstruction-clinical-and-magnetic-resonance-imaging-results
#13
Dhong Won Lee, Ji Whan Lee, Sang Bum Kim, Jung Ho Park, Kyu Sung Chung, Jeong Ku Ha, Jin Goo Kim, Woo Jong Kim
BACKGROUND: The purpose of this study was to compare the clinical and radiological results of 2 different tibial fixations performed using bioabsorbable screws with added hydroxyapatite (HA) and pure poly-L-lactic acid (PLLA) screws in anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 394 patients who underwent arthroscopic ACL reconstruction between March 2009 and June 2012 were retrospectively reviewed. Of those, 172 patients who took the radiological and clinical evaluations at more than 2 years after surgery were enrolled and divided into 2 groups: PLLA group (n = 86) and PLLA-HA group (n = 86)...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28839352/reconstruction-of-traumatic-bone-loss-using-the-induced-membrane-technique-preliminary-results-about-11-cases
#14
Noufanangue Kanfitine Kombate, Atchi Walla, Gamal Ayouba, B Moïse Bakriga, Yaovi Yannick Dellanh, Anani Grégoire Abalo, Assang Michel Dossim
INTRODUCTION: The use of Masquelet technique is a serious option to consider for biologic reconstruction of severe bone loss. Here is exposed a continuous and prospective study on bone loss management using that technique. The aims of this study were to assess epidemiology of bone loss due either to trauma or to non-unions and to give preliminary results. PATIENTS AND METHODS: It was a prospective study from April 2015 to december 2016 involving patients treated using the induced membrane technique for a diaphyseal bone defect due either to trauma or non-unions...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28798870/histopathological-and-imageological-studies-on-clinical-outcomes-of-mineralized-collagen-reconstruction-rod-for-femoral-head-necrosis-with-one-case-report
#15
Baogang Xie, Hao Wang, Jianhua Hao, Ping Wang, Na Zhang, Jingjing Wu, Zhiye Qiu, Fuzhai Cui
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head, interface between the host bone and implant and the bone reconstruction process. The results showed that the density of rods increased closed to that of host bones after 1 year implanting, and the interface between them turns to blurring...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28793006/osteointegration-of-porous-absorbable-bone-substitutes-a-systematic-review-of-the-literature
#16
Maria Júlia Escanhoela Paulo, Mariana Avelino Dos Santos, Bruno Cimatti, Nelson Fabrício Gava, Marcelo Riberto, Edgard Eduard Engel
Biomaterials' structural characteristics and the addition of osteoinductors influence the osteointegration capacity of bone substitutes. This study aims to identify the characteristics of porous and resorbable bone substitutes that influence new bone formation. An Internet search for studies reporting new bone formation rates in bone defects filled with porous and resorbable substitutes was performed in duplicate using the PubMed, Web of Science, Scielo, and University of São Paulo Digital Library databases...
July 2017: Clinics
https://www.readbyqxmd.com/read/28783082/incorporation-of-collagen-in-calcium-phosphate-cements-for-controlling-osseointegration
#17
Ming-Hsien Hu, Pei-Yuan Lee, Wen-Cheng Chen, Jin-Jia Hu
In this study, we investigated the effect of supplementing a non-dispersive dicalcium phosphate-rich calcium phosphate bone cement (DCP-rich CPC) with type I collagen on in vitro cellular activities and its performance as a bone graft material. Varying amounts of type I collagen were added during the preparation of the DCP-rich CPC. In vitro cell adhesion, morphology, viability, and alkaline phosphatase (ALP) activity were evaluated using progenitor bone cells. Bone graft performance was evaluated via a rat posterolateral lumbar fusion model and osteointegration of the implant...
August 6, 2017: Materials
https://www.readbyqxmd.com/read/28773906/novel-resorbable-and-osteoconductive-calcium-silicophosphate-scaffold-induced-bone-formation
#18
Patricia Ros-Tárraga, Patricia Mazón, Miguel A Rodríguez, Luis Meseguer-Olmo, Piedad N De Aza
This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5-1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material's interior...
September 20, 2016: Materials
https://www.readbyqxmd.com/read/28773884/novel-osteointegrative-sr-substituted-apatitic-cements-enriched-with-alginate
#19
Simone Sprio, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Wanda Lattanzi, Enrico Pola, Giandomenico Logroscino, Anna Tampieri
The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration...
September 8, 2016: Materials
https://www.readbyqxmd.com/read/28765800/fortifying-the-bone-implant-interface-part-2-an-in-vivo-evaluation-of-3d-printed-and-tps-coated-triangular-implants
#20
Regina F MacBarb, Derek P Lindsey, Shane A Woods, Peggy A Lalor, Mukund I Gundanna, Scott A Yerby
BACKGROUND: Minimally invasive surgical fusion of the sacroiliac (SI) joint using machined solid triangular titanium plasma spray (TPS) coated implants has demonstrated positive clinical outcomes in SI joint pain patients. Additive manufactured (AM), i.e. 3D-printed, fenestrated triangular titanium implants with porous surfaces and bioactive agents, such as nanocrystalline hydroxyapatite (HA) or autograft, may further optimize bony fixation and subsequent biomechanical stability. METHODS: A bilateral ovine distal femoral defect model was used to evaluate the cancellous bone-implant interfaces of TPS-coated and AM implants...
2017: International Journal of Spine Surgery
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