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rheumatoid arthritis extraarticular manifestation

Massimo Cugno, Roberta Gualtierotti, Pier Luigi Meroni, Angelo Valerio Marzano
Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates...
July 22, 2017: Clinical Reviews in Allergy & Immunology
Lisa Theander, Britt-Marie Nyhäll-Wåhlin, Jan-Åke Nilsson, Minna Willim, Lennart T H Jacobsson, Ingemar F Petersson, Carl Turesson
OBJECTIVE: The aims of this study were to evaluate whether treatment with tumor necrosis factor (TNF) inhibitors in patients with rheumatoid arthritis (RA) affects the risk of developing severe extraarticular rheumatoid arthritis (ExRA) manifestations and to investigate potential predictors for developing ExRA. METHODS: A dynamic community-based cohort of patients with RA was studied (n = 1977). Clinical records were reviewed and cases of severe ExRA were identified...
July 2017: Journal of Rheumatology
Anne-Mette Kristensen, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Per Höllsberg, Bent Deleuran, Malene Hvid
Rheumatoid arthritis (RA) is an autoimmune disease which may lead to severe disabilities due to structural joint damage and extraarticular manifestations The dendritic cell marker CD83 belongs to the immunoglobulin superfamily and has previously been associated with autoimmune diseases. In RA the levels of soluble CD83 (sCD83) are elevated in synovial fluid, however little is known about CD83 expression and regulation in RA. Therefore, we studied how CD83 is expressed in RA and further evaluated the effect of anti-TNF-α therapy hereon...
March 3, 2017: Cytokine
Emeline Minichiello, Luca Semerano, Marie-Christophe Boissier
INTRODUCTION: Rheumatoid arthritis (RA) generates a heavy socioeconomic burden. The ability to predict the frequency and severity of socioeconomic effects due to RA is crucial to the development of public health policies. OBJECTIVE: To conduct a systematic literature review of data on the prevalence, incidence, and severity of RA. METHODS: Medline, EMBASE, the Cochrane Library, and online American College of Rheumatology communications were searched for articles on the prevalence and incidence of RA, as well as on selected severity and activity criteria...
December 2016: Joint, Bone, Spine: Revue du Rhumatisme
Boris Kubuschok, Klaus-Dieter Preuss, Kerstin Baier-Thoenes, Evi Regitz, Lorenz Thurner, Gunter Assmann, Michael Pfreundschuh
OBJECTIVES: Autoantibodies may play a role in the pathogenesis of primary vasculitides (PVs) like giant cell arteritis (GCA). We recently identified 3 cytoskeletal proteins (lamin C [laC], nuclear autoantigen of 14kD [NA14] and cytokeratin 15 [CK15]) as autoantigens in GCA and postulated a frequent autoantibody response against these antigens in PVs. METHODS: To test this hypothesis we studied a cohort of patients with PVs (n=61) and healthy individuals (n=27) for the presence of these autoantibodies using a recombinant cDNA expression library...
May 2016: Clinical and Experimental Rheumatology
Agnieszka Matuszewska, Marta Madej, Piotr Wiland
Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and death mainly due to premature cardiovascular disease. Early diagnosis and appropriate treatment are essential for prognosis and quality of life improvement. In 2010 the American College of Rheumatology (ACR) and The European League Against Rheumatism (EULAR) established new RA classification criteria...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Zsuzsa Schmidt, Gyula Poór
Polymyalgia rheumatica is an inflammatory musculoskeletal disorder of people aged 50 years or over, characterised by pain, aching and morning stiffness in the shoulder girdle and often hip girdle and neck. Marked systemic inflammation and rapid response to corticosteroid therapy are characteristic features. Giant cell arteritis is a well-known association of polymyalgia rheumatica. Recent clinical evidence and scientific results in the field have provided new challenges for rheumatologists. Besides the aspecific - although characteristic - proximal syndrome, less well recognizable and more variable distal musculoskeletal manifestations were observed...
January 3, 2016: Orvosi Hetilap
Chung-Ming Huang, Shih-Yin Chen, Po-Hao Huang, Fuu-Jen Tsai
OBJECTIVE: This study examined the role of SNP rs2858056 of the MPG gene on the incidence and severity of rheumatoid arthritis (RA). METHODS: This cohort study enrolled 365 RA patients and 375 age- and gender-matched healthy controls, all of whom had Han Chinese ethnicity and were from Taiwan. Gene polymorphism of the SNP rs2858056 of MPG was determined from genomic DNA. Allelic frequencies and genotypes were compared among cases and controls. Quantitation of rs2858056 copy number variation (CNV) was determined...
2015: PloS One
María Jezabel Haye Salinas, Soledad Retamozo, Ana Cecilia Alvarez, Hernán Maldonado Ficco, Fernando Dal Pra, Gustavo Citera, Mariana Benegas, Rafael Chaparro del Moral, Oscar Rillo, Anastasia Secco, Lucila Marino Claverie, Antonio Catalan Pellet, Josefina Marcos, Mercedes Argentina García, Juan Carlos Marcos, Ana Barbaglia, Verónica Bellomio, Alberto Berman, Cristian Quiroz, Enrique R Soriano, Federico Ceccato, Sergio Paira, Doralia Vazquez, Vicente Ricardo Juarez, Edson Javier Velozo, Gabriela Salvatierra, Francisco Caeiro
Our objective was to analyze the effects of cigarette smoking on disease activity, functional capacity, radiographic damage, serology and presence of extraarticular manifestations in patients with rheumatoid arthritis and undifferentiated arthritis. This is a cross-sectional study of 1,305 patients (729 with rheumatoid arthritis and 576 with undifferentiated arthritis) from CONAART, the Argentine Consortium for Early Arthritis that includes patients older than 16 years with <2 years of disease. Sociodemographic data, clinical characteristics of the disease and smoking history were collected...
May 2015: Rheumatology International
Branimir Anić, Miroslav Mayer
Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA patients there is no clear predisposing factor present. Environmental factors involved in RA pathogenesis are cigarette smoke, industrial pollutants like silica crystals, disturbances of intestinal, lung, and oral microbiota and some specific bacterial and viral infectious agents and their components...
2014: Reumatizam
Agnieszka Paradowska-Gorycka, Monika Jurkowska, Anna Felis-Giemza, Katarzyna Romanowska-Próchnicka, Malgorzata Manczak, Slawomir Maslinski, Marzena Olesinska
OBJECTIVE: The aim of the study was to identify 2 polymorphic variants in the promoter region of the Foxp3 gene and their possible association with susceptibility to and severity of rheumatoid arthritis (RA). The association between genetic factors and pathogenesis suggests that T cells take part in the induction of RA. The CD4+CD25highFoxp3+ subset of regulatory T cells plays an essential role in preventing autoimmunity and maintaining immune homeostasis. METHODS: Patients with RA (n = 274) and healthy individuals (n = 295) were examined for -3279 C/A and -924 A/G Foxp3 gene polymorphisms by the polymerase chain reaction-restriction fragment-length polymorphism method...
February 2015: Journal of Rheumatology
Branimir Anić, Miroslav Mayer
Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA patients there is no clear predisposing factor present. Environmental factors involved in RA pathogenesis are cigarette smoke, industrial pollutants like silica crystals, disturbances of intestinal, lung, and oral microbiota and some specific bacterial and viral infectious agents and their components...
2014: Reumatizam
Juan Chen, Tracy J Doyle, Yongliang Liu, Rohit Aggarwal, Xiaoping Wang, Yonghong Shi, Sheng Xiang Ge, Heqing Huang, Qingyan Lin, Wen Liu, Yongjin Cai, Diane Koontz, Carl R Fuhrman, Maria F Golzarri, Yushi Liu, Hiroto Hatabu, Mizuki Nishino, Tetsuro Araki, Paul F Dellaripa, Chester V Oddis, Ivan O Rosas, Dana P Ascherman
OBJECTIVE: Interstitial lung disease (ILD) is a relatively common extraarticular manifestation of rheumatoid arthritis (RA) that contributes significantly to disease burden and excess mortality. The purpose of this study was to identify peripheral blood markers of RA-associated ILD that can facilitate earlier diagnosis and provide insight regarding the pathogenesis of this potentially devastating disease complication. METHODS: Patients with RA who were enrolled in a well-characterized Chinese identification cohort or a US replication cohort were subclassified as having RA-no ILD, RA-mild ILD, or RA-advanced ILD, based on high-resolution computed tomography scans of the chest...
January 2015: Arthritis & Rheumatology
Andra Florina Negoescu, Dilrukshi Tennekone, Michael Anthony Soljak, Sonya Marie Abraham
OBJECTIVE: To assess the evolution of preexisting extraarticular manifestations of rheumatoid arthritis (EA-RA) in patients treated with anti-tumor necrosis factor-α (TNF-α), as well as the development of new EA-RA. METHODS: We assessed EA-RA in 152 patients receiving anti-TNF-α treatment. RESULTS: In 22 cases, a new EA-RA developed. In 5 cases, there was evidence of progression of preexisting EA-RA. Regression was found in 4 cases. Some patients were in disease remission when they developed EA-RA, whereas some patients had moderate/high disease activity...
October 2014: Journal of Rheumatology
E V Gerasimova, T V Popkova, D S Novikova, E L Nasonov
AIM: To compare the prevalence of risk factors, clinical and subclinical manifestations of cardiovascular diseases (CVD) and their complications in methotrexate (MT)-treated and untreated patients with rheumatoid arthritis. SUBJECTS AND METHODS: The investigation enrolled 193 patients (168 women and 25 men) less than 60 years of age (mean age 49 [44; 53] years) with RA. The patients were divided into 2 groups: 1) 69 patients who received MT in a dose of 15.1 [10...
2014: Terapevticheskiĭ Arkhiv
Martin Soubrier, Nicolas Barber Chamoux, Zuzana Tatar, Marion Couderc, Jean-Jacques Dubost, Sylvain Mathieu
The objectives of this review are to discuss data on the cardiovascular risk increase associated with rheumatoid arthritis (RA), the effects of RA treatments on the cardiovascular risk level, and the management of cardiovascular risk factors in patients with RA. Overall, the risk of cardiovascular disease is increased 2-fold in RA patients compared to the general population, due to the combined effects of RA and conventional risk factors. There is some evidence that the cardiovascular risk increase associated with nonsteroidal anti-inflammatory drug therapy may be smaller in RA patients than in the general population...
July 2014: Joint, Bone, Spine: Revue du Rhumatisme
Clément Prati, Céline Demougeot, Xavier Guillot, Marie Godfrin-Valnet, Daniel Wendling
Inflammatory joint diseases and autoimmune diseases with joint manifestations are associated with premature and accelerated atherogenesis. Patients with rheumatoid arthritis (RA) have a 5- to 10-year decrease in life expectancy compared to the general population, and those exhibiting extraarticular manifestations have the greatest excess mortality. RA is now established as an independent cardiovascular risk factor. Complex interactions linking conventional cardiovascular risk factors, systemic inflammation, and vascular function may explain the increased cardiovascular risk among RA patients...
October 2014: Joint, Bone, Spine: Revue du Rhumatisme
Sophie Mavrogeni, Theodoros Dimitroulas, Chiara Bucciarelli-Ducci, Stacy Ardoin, Petros P Sfikakis, Genovefa Kolovou, George D Kitas
Rheumatoid arthritis (RA) is a systemic, inflammatory disease with female preponderance, characterized by severe articular and extraarticular manifestations. Cardiovascular (CV) disease in RA usually occurs a decade earlier than age- and sex-matched controls and patients with RA are twice more likely to develop myocardial infarction irrespective of age, history of prior CVD events and traditional CV risk factors. It has been shown that atherosclerotic CV disease in RA shares similarities with CV disease in diabetes mellitus (DM) in terms of clinical presentation and preclinical atherosclerosis...
2014: Inflammation & Allergy Drug Targets
Kaisa E Happonen, Tore Saxne, Lennart Jacobsson, Gunnar Sturfelt, Johan Rönnelid, Tom Eirik Mollnes, Dick Heinegård, Carl Turesson, Anna M Blom
OBJECTIVE: To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular manifestations. METHODS: Cartilage oligomeric matrix protein (COMP), COMP-C3b, and soluble terminal complement complexes (sTCC) were measured by ELISA. RESULTS: COMP-C3b levels were higher in patients with RA than in healthy controls and lower in extraarticular RA (ExRA) than in RA controls. In patients with ExRA, sTCC levels were higher than in RA controls, and correlated inversely with serum COMP-C3b levels in the ExRA group...
December 2013: Journal of Rheumatology
Chuanhui Xu, Xiuru Wang, Rong Mu, Li Yang, Ye Zhang, Shuling Han, Xiaofeng Li, Yongfu Wang, Guochun Wang, Ping Zhu, Hongtao Jin, Lin Sun, Haiying Chen, Liufu Cui, Zhuoli Zhang, Zhenbin Li, Junfang Li, Fengxiao Zhang, Jinying Lin, Xiaomin Liu, Shaoxian Hu, Xiuyan Yang, Bei Lai, Xingfu Li, Xiaoyuan Wang, Yin Su, Zhanguo Li
OBJECTIVE: To estimate the annual direct and indirect costs of rheumatoid arthritis (RA) in China and identify the predictors for cost of illness. METHODS: A cross-sectional study of cost of illness from the societal perspective was conducted on 829 patients with RA in 21 tertiary care hospitals in China between July 2009 and December 2010. Data on demographics, clinical variables, and components of costs were collected by physician interview. Costs were represented in 2009 US dollars using purchasing power parity estimates...
April 2014: Arthritis Care & Research
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