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https://www.readbyqxmd.com/read/29153098/high-amplification-levels-of-mdm2-and-cdk4-correlate-with-poor-outcome-in-patients-with-dedifferentiated-liposarcoma-a-cytogenomic-microarray-analysis-of-47-cases
#1
Robert W Ricciotti, Aaron J Baraff, George Jour, McKenna Kyriss, Yu Wu, Yuhua Liu, Shao-Chun Li, Benjamin Hoch, Yajuan J Liu
Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. To this end, we studied 49 cases of DDLS in our institutional archives and performed cytogenomic microarray analysis on 47 cases. Gene copy numbers for 12 loci were evaluated and correlated with outcome data retrieved from our institutional electronic medical records...
December 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29142149/liposarcoma-of-the-spermatic-cord-in-a-toy-poodle
#2
Daji Noh, Wooson Choi, Woochan Son, Manhee Lee, Seungchun Park, Kija Lee
Liposarcoma of the spermatic cord is extremely rare in dogs and humans. This report describes the clinical signs, typical diagnostic imaging including ultrasound and computed tomography, and treatment of a liposarcoma of the spermatic cord of a Toy Poodle confirmed by histological examination after a surgical procedure. This case highlights the importance of preoperative diagnostic imaging and histopathological examination in dogs with an inguinal or scrotal mass.
November 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29139652/liposarcoma-of-the-spermatic-cord-%C3%A2-a-rare-pathological-entity
#3
Nikola Radović, Arianna Bizatzki, Rajka Turner
Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Ultrasonography revealed a homogenous isodense mass measuring 4...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29132397/kinase-profiling-of-liposarcomas-using-rnai-and-drug-screening-assays-identified-druggable-targets
#4
Deepika Kanojia, Manoj Garg, Jacqueline Martinez, Anand M T, Samuel B Luty, Ngan B Doan, Jonathan W Said, Charles Forscher, Jeffrey W Tyner, H Phillip Koeffler
BACKGROUND: Liposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic targets. However, very limited knowledge exists of therapeutic critical kinase targets in liposarcoma that could be potentially used in disease management. METHODS: Large RNAi and small-molecule tyrosine kinase inhibitor screens were performed against the proliferative capacity of liposarcoma cell lines of different subtypes...
November 13, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29128479/adipocyte-size-variability-in-benign-and-malignant-lipomatous-tumors-and-morphologic-mimics-a-quantitative-definition-using-digital-pathology
#5
Gregory R Bean, Kwun Wah Wen, Andrew E Horvai
Among well-differentiated lipomatous lesions, variability in adipocyte size has been proposed as a morphologic feature of malignancy. Specifically, normal adipose tissue and benign lipomas tend to contain adipocytes of uniform size, whereas atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) are described as containing adipocytes with a conspicuous variation in cell size. However, this proposed variance has never been objectively, quantitatively correlated with diagnosis. Using whole slide scanning combined with semiautomated digital image analysis, we aimed to quantitatively test the hypothesis that variance in adipocyte size is a feature of malignancy in well-differentiated lipomatous tumors...
November 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/29127917/a-giant-mediastinal-liposarcoma-weighing-3500g-resected-with-clam-shell-approach-a-case-report-with-review-of-literature
#6
Yasoo Sugiura, Toshinori Hashizume, Hiroyuki Fujimoto, Etsuo Nemoto
INTRODUCTION: Liposarcoma is rare in the mediastinum and is less than 1% of all mediastinal tumors. In the present report, we demonstrated our case and summarized the principal treatment of the mediastinal liposarcoma with literature review. PRESENTATION OF CASE: A 50-year-old man presented at our hospital with complain of dyspnea. Chest radiography showed remarkable cardiomegaly. Computed tomography revealed an anterior mediastinal tumor from the level of the cephalic vein to the diaphragm of bilateral thoracic cavity with fat component...
November 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29104083/development-and-evaluation-of-a-pan-sarcoma-fusion-gene-detection-assay-using-the-nanostring-ncounter-platform
#7
Kenneth T E Chang, Angela Goytain, Tracy Tucker, Aly Karsan, Cheng-Han Lee, Torsten O Nielsen, Tony L Ng
The NanoString nCounter assay is a high-throughput hybridization technique using target-specific probes that can be customized to test for numerous fusion transcripts in a single assay using RNA from formalin-fixed, paraffin-embedded material. We designed a NanoString assay targeting 174 unique fusion junctions in 25 sarcoma types. The study cohort comprised 212 cases, 96 of which showed fusion gene expression by the NanoString assay, including all 20 Ewing sarcomas, 11 synovial sarcomas, and 5 myxoid liposarcomas tested...
November 17, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29076540/osteogenic-differentiation-in-dedifferentiated-liposarcoma-a-study-of-36-cases-in-comparison-to-the-cases-without-ossification
#8
Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Takeaki Ishii, Yoshihiro Nishida, Hiroshi Urakawa, Ichiro Ito, Mitsuru Takahashi, Takeshi Inoue, Masafumi Ito, Yuuki Ohara, Yoshinao Oda, Shinya Toyokuni
AIMS: Ossification is occasionally found in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumor cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. METHODS AND RESULTS: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27/28) using fluorescence in-situ hybridization, although morphological impression of ossification was mostly metaplastic looking (27/36) or high grade osteosarcoma like (6/36)...
October 27, 2017: Histopathology
https://www.readbyqxmd.com/read/29076490/-transhepatic-approach-for-recurrent-retroperitoneal-liposarcoma
#9
Yu I Patyutko, N E Kudashkin, V M Samoylenko, A G Kotelnikov
No abstract text is available yet for this article.
2017: Khirurgiia
https://www.readbyqxmd.com/read/29075871/-soft-tissue-tumors-epidemiology-classification-and-staging
#10
L Fenzl, M Mehrmann, K Kremp, G Schneider
Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. g. undifferentiated sarcomas have been formed into a new subgroup and are no longer assigned to the fibrohistiocytic tumors. The term malignant fibrous histiocytoma has been replaced by the undifferentiated sarcoma...
November 2017: Der Radiologe
https://www.readbyqxmd.com/read/29069637/redox-active-metals-and-h2o2-mediate-the-increased-efficacy-of-pharmacological-ascorbate-in-combination-with-gemcitabine-or-radiation-in-pre-clinical-sarcoma-models
#11
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Megan D Bradley, Brett A Wagner, Garry R Buettner, Varun Monga, Mohammed Milhem, Douglas R Spitz, Bryan G Allen
Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20mM plasma levels) is a potentially efficacious and easily integrable addition to current standard of care treatment strategies in preclinical models of fibrosarcoma and liposarcoma both in vitro and in vivo. Furthermore, enhanced ascorbate-mediated toxicity and DNA damage in these sarcoma models were found to be dependent upon H2O2 and intracellular labile iron...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/29067922/primary-adrenal-teratoma-an-unusual-tumor-challenges-in-diagnosis-and-surgical-management
#12
P Ramakant, C Rana, K R Singh, A Mishra
We report a rare case of a 25-year-old lady who presented with right hypochondriac pain associated with weakness for 3 months. Her hormonal evaluation was normal. Computed tomography scan revealed an adrenal mass for which a right open transperitoneal adrenalectomy was performed, and the lesion was diagnosed as mature teratoma on histopathological examination. Teratoma is an unusual neoplasm which arises from one or all the three germ layers. Extragonadal teratomas are rare in adults as compared to children and are mostly retroperitoneal in location, constituting only 4% of all primary teratomas...
October 23, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29067605/surgical-management-of-primary-retroperitoneal-sarcomas-rationale-for-selective-organ-resection
#13
Mark Fairweather, Jiping Wang, Vickie Y Jo, Elizabeth H Baldini, Monica M Bertagnolli, Chandrajit P Raut
BACKGROUND: Recently, some have argued for routine resection of adjacent but uninvolved organs in patients with retroperitoneal sarcoma (RPS) without stipulating the rationale for such organ resection (beyond the need to achieve a macroscopically complete resection) or examining histopathologic organ invasion (HOI). This study reviewed the authors' experience with primary RPS to investigate the rate and rationale for individual organ resection and the rate of HOI. METHODS: Operative and pathology reports for patients with primary RPS who underwent resection at our institution were retrospectively reviewed...
October 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29061812/tumor-suppression-efficacy-of-heat-shock-protein-90-inhibitor-17aag-in-a-liposarcoma-mouse-model
#14
Seunghoon Nam, Hyungjoon Kim, Doopyo Hong, Jae Berm Park, Sung Joo Kim
BACKGROUND/AIM: Heat shock protein 90 (HSP90) inhibitors have recently been tested as anticancer drugs in a variety of carcinomas. Yet, there exist only few reports about HSP90 inhibitor and its thepeutic effect on liposarcoma. The therapeutic effects of HSP90 inhibitors have been mainly observed in oncogenic and tumor angiogenic signaling cascades by observing tumor growth. MATERIALS AND METHODS: We used the the LPS 246 liposarcoma cell line and GS-076 PDC (patient-derived cell lines)...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29050100/-one-case-report-of-pleomorphic-liposarcoma-of-larynx
#15
Z D Hu, J Yan, W J Cai, D Zhang, X X Guo, Z Q Yin, M F Zhang
No abstract text is available yet for this article.
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29050077/-detection-of-fusion-gene-transcript-in-formalin-fixed-paraffin-embedded-myxoid-round-cell-liposarcoma-tissues-by-improved-reverse-transcription-polymerase-chain-reaction
#16
Y H Hao, X W Chen, L Wang, X B Tang
No abstract text is available yet for this article.
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29046788/a-rare-case-of-dedifferentiated-liposarcoma-of-the-sinonasal-cavity-a-case-report
#17
Masaru Miyazaki, Mikiko Aoki, Satoru Oba, Toshifumi Sakata, Takashi Nakagawa, Kazuki Nabeshima
Sarcoma is an uncommon histopathological presentation of sinonasal tumors, comprising ~15% of all cases; liposarcoma is particularly uncommon. An analysis of the available medical literature revealed no prior reports of dedifferentiated liposarcoma (DDLPS) of the sinonasal cavity. This case report presents a rare case of DDLPS of the sinonasal cavity. A 40-year old six-week pregnant female was admitted with a left nasal obstruction. Endoscopic evaluation of the left nasal cavity revealed a polypoid lesion. A computed tomography scan indicated a mass invading the left nasal cavity, maxillary sinus and anterior ethmoid sinus with focal destruction of the surrounding bone...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29040487/pedunculated-liposarcoma-of-the-esophagus
#18
G B Salis, J C Albertengo, M Bruno, G Palau, R González Villaveirán, D Lombardo, V Villafañe, C Zorraquín, M Ghigliani
Polypoid tumours of the esophagus present diagnostic and therapeutic problems. Liposarcomas are infrequent among them. We report a recent case. A 73-year-old male patient was seen in May 1995 in the Ear, Nose and Throat (ENT) Department, Clinica Modelo de Morón, with intermittent dysphagia and dyspnoea due to recurrent vomiting. A laryngeal lineal tomography showed a subglottic obstruction due to extrinsic compression. The patient was referred to the Gastroenterology Department, where an upper gastrointestinal (upper GI) series demonstrated mega-esophagus with abundant retained food...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29031176/a-case-of-dedifferentiated-liposarcoma-of-the-heart-and-stomach
#19
Yoichi Hisata, Yuichi Tasaki, Satoshi Kozaki, Takafumi Yamada
INTRODUCTION: Liposarcoma of the heart and stomach is rare. PRESENTAION OF CASE: We report a case of liposarcoma in both organs with dedifferentiated histology. A patient was referred to our hospital with anorexia and weight loss. Upper gastrointestinal tract endoscopy revealed 5-10-mm elevated lesions, and echocardiography and computed tomography showed tumorous lesions in the left atrium. Tumor resection and mitral valve replacement were performed, and biopsy was performed for the gastric tumor...
October 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29028101/topbp1-promotes-malignant-progression-and-correlates-with-poor-prognosis-in-osteosarcoma
#20
D-P Wu, X-B Yan, L-G Liu, C Tian, K Han, H Zhang, D-L Min
OBJECTIVE: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many cancer types. This study aimed to evaluate the biological role and clinicopathological significance of TopBP1 in OS. PATIENTS AND METHODS: TopBP1 expression in sarcoma patients was determined through the Oncomine database, and the prognostic role of TopBP1 expression was assessed in a retrospective cohort study...
September 2017: European Review for Medical and Pharmacological Sciences
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