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https://www.readbyqxmd.com/read/29789718/pdlim7-and-cdh18-regulate-the-turnover-of-mdm2-during-cdk4-6-inhibitor-therapy-induced-senescence
#1
Mary E Klein, Mark A Dickson, Cristina Antonescu, Li-Xuan Qin, Scott J Dooley, Afsar Barlas, Katia Manova, Gary K Schwartz, Aimee M Crago, Samuel Singer, Andrew Koff, William D Tap
CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is associated with their ability to downregulate the MDM2 protein. The downregulation of MDM2 following treatment with CDK4/6 inhibitors also induces many cultured tumor cell lines derived from different types of malignancies to progress from quiescence into senescence. Here we used cultured human cell lines and defined a role for PDLIM7 and CDH18, regulating MDM2 protein in CDK4/6 inhibitor-treated cells...
May 23, 2018: Oncogene
https://www.readbyqxmd.com/read/29788010/metaplastic-breast-cancer-masquerading-as-liposarcoma-of-the-breast-a-case-report-following-oncoplastic-treatment
#2
Maiar Elghobashy, Naren Basu, Robert Warner, John Dickson, Abeer M Shaaban
Mammary liposarcoma is among the rarest of breast tumours. Here we report the presentation, macroscopic, microscopic, and immunohistochemical features of an extremely rare case of metaplastic carcinoma with extensive pleomorphic liposarcomatous differentiation. A 47-year-old woman presented with bilateral grade III breast ptosis and a 3 × 4 cm mass in the lower outer quadrant of the left breast. Mammography and ultrasound confirmed a well-defined mass. A core biopsy performed was diagnosed as pleomorphic liposarcoma...
May 22, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29785138/a-review-of-soft-tissue-sarcomas-translation-of-biological-advances-into-treatment-measures
#3
REVIEW
Ngoc T Hoang, Luis A Acevedo, Michael J Mann, Bhairavi Tolani
Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an overall incidence of about five per 100,000 per year. While this diverse family of malignancies comprises over 100 histological subtypes and many molecular aberrations are prevalent within specific sarcomas, very few are therapeutically targeted. Instead of utilizing molecular signatures, first-line sarcoma treatment options are still limited to traditional surgery and chemotherapy, and many of the latter remain largely ineffective and are plagued by disease resistance...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29784880/arginine-methylation-of-translocated-in-liposarcoma-tls-inhibits-its-binding-to-long-noncoding-rna-abrogating-tls-mediated-repression-of-cbp-p300-activity
#4
Wei Cui, Ryoma Yoneda, Naomi Ueda, Riki Kurokawa
Translocated in liposarcoma (TLS) is an RNA-binding protein and a transcription-regulatory sensor of DNA damage. TLS binds promoter-associated noncoding RNA (pncRNA) and inhibits histone acetyltransferase (HAT) activity of CREB-binding protein (CBP)/E1A-binding protein P300 (p300) on the cyclin D1 (CCND1) gene. Although post-translational modifications of TLS, such as arginine methylation, are known to regulate TLS's nucleocytoplasmic shuttling and assembly in stress granules, its interactions with RNAs remain poorly characterized...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29774221/magnetic-resonance-imaging-findings-for-differential-diagnosis-of-perianal-plexiform-schwannoma-case-report-and-review-of-the-literature
#5
Xue-Liang Sun, Ke Wen, Zhi-Zhong Xu, Xiao-Peng Wang
Plexiform schwannoma is an extremely rare variant of schwannoma, accounting for approximately 5% of cases. Due to the rarity and lack of typical symptoms, signs and radiological images, a definite diagnosis of plexiform schwannoma may not be made by clinicians prior to biopsy. In the present study, we report the first case (to our knowledge) of perianal plexiform schwannoma arising from the overlapped skin of the ischioanal fossa, and we propose an intratumorally nonenhanced circumferential capsule dividing the tumour into multiple homogeneously enhanced nodules as a magnetic resonance imaging feature to aid in the differential diagnosis of plexiform schwannoma from ancient schwannoma, cavernous haemangioma, liposarcoma and plexiform neurofibroma...
May 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29772614/-a-case-of-retroperitoneal-liposarcoma-in-which-magnetic-resonance-imaging-was-useful-in-the-decision-of-resection-of-primary-and-recurrenttumors
#6
Sohei Kuribayashi, Yasutomo Nakai, Hirotaka Tsuji, Satoru Yumiba, Koji Hatano, Masashi Nakayama, Kenichi Kakimoto, Chiaki Kubo, Kazuo Nishimura
A 47-year-old female was referred to our hospital because of retroperitoneal tumor which was detected by computer tomography (CT). Since the tumor was considered to be benign by magnetic resonance imaging (MRI), she was followed by MRI every 3 months. The site of the tumor was gradually increased, and 15 months after presentation, a lesion with high signal intensity on diffusion weighted image (DWI) appeared in the tumor. At that time, we performed tumor resection considering the tumor to be malignant. Pathological diagnosis was dedifferentiated liposarcoma...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29768052/options-for-treating-different-soft-tissue-sarcoma-subtypes
#7
Isabelle Ray-Coquard, Delphine Serre, Peter Reichardt, Javier Martín-Broto, Sebastian Bauer
Management of soft tissue sarcoma is increasingly subtype-dependent. Surgery is recommended for uterine leiomyosarcoma, with trabectedin being the preferred option for advanced disease when the treatment goal is long-term tumor stabilization. Liposarcoma subgroups are characterized by distinctive morphologies and genetics, different patterns of disease progression and clinical behavior, and variable responses to treatment. Genetic analysis of sarcomas has provided insights into pathogenesis with potential for developing new molecular targets...
May 2018: Future Oncology
https://www.readbyqxmd.com/read/29758120/concomitant-administration-of-radiation-with-eribulin-improves-the-survival-of-mice-harboring-intracerebral-glioblastoma
#8
Shunichiro Miki, Shoji Imamichi, Hiroaki Fujimori, Arata Tomiyama, Kenji Fujimoto, Kaishi Satomi, Yuko Matsushita, Sanae Matsuzaki, Masamichi Takahashi, Eiichi Ishikawa, Tetsuya Yamamoto, Akira Matsumura, Akitake Mukasa, Ryo Nishikawa, Kenkichi Masutomi, Yoshitaka Narita, Mitsuko Masutani, Koichi Ichimura
Glioblastoma is the most common and devastating type of malignant brain tumor. We recently found that eribulin suppresses glioma growth in vitro and in vivo and that eribulin is efficiently transferred into mouse brain tumors at a high concentration. Eribulin is a non-taxane microtubule inhibitor approved for breast cancer and liposarcoma. Cells arrested in M-phase by chemotherapeutic agents such as microtubule inhibitors are highly sensitive to radiation-induced DNA damage. Several recent case reports demonstrated the clinical benefits of eribulin combined with radiation therapy for metastatic brain tumors...
May 14, 2018: Cancer Science
https://www.readbyqxmd.com/read/29755284/the-value-of-mri-in-distinguishing-subtypes-of-lipomatous-extremity-tumors-needs-reassessment-in-the-era-of-mdm2-and-cdk4-testing
#9
Sean Ryan, Julia Visgauss, David Kerr, Joshua Helmkamp, Nicholas Said, Emily Vinson, Patrick O'Donnell, Xuechan Li, Sin-Ho Jung, Diana Cardona, William Eward, Brian Brigman
Introduction: Extremity lipomas and well-differentiated liposarcomas (WDLs) are difficult to distinguish on MR imaging. We sought to evaluate the accuracy of MRI interpretation using MDM2 amplification, via fluorescence in-situ hybridization (FISH), as the gold standard for pathologic diagnosis. Furthermore, we aimed to investigate the utility of a diagnostic formula proposed in the literature. Methods: We retrospectively collected 49 patients with lipomas or WDLs utilizing MDM2 for pathologic diagnosis...
2018: Sarcoma
https://www.readbyqxmd.com/read/29750003/dedifferentiated-retroperitoneal-liposarcoma-spontaneously-occurring-in-an-aged-sd-rat
#10
Tomoharu Naito, Tsuyoshi Saito, Tamami Higuchi, Akira Inomata, Takuo Hayashi, Yasuhiro Shimada, Atsuko Yamauchi-Ohguchi, Sayaka Kenmochi, Chihaya Kakinuma, Takashi Yao
Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Microscopically, the tumor had a well-differentiated component and dedifferentiated high-grade component...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29744029/treatment-patterns-and-survival-among-older-adults-in-the-united-states-with-advanced-soft-tissue-sarcomas
#11
Rohan C Parikh, Maria Lorenzo, Lisa M Hess, Sean D Candrilli, Steven Nicol, James A Kaye
Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes. Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29740489/dedifferentiated-liposarcoma-of-the-oral-floor-a-case-study-and-literature-review-of-50-cases-of-head-and-neck-neoplasm
#12
Fumikazu Nimura, Toshiyuki Nakasone, Hirofumi Matsumoto, Tessho Maruyama, Akira Matayoshi, Nobuyuki Maruyama, Naoki Yoshimi, Akira Arasaki, Kazuhide Nishihara
Dedifferentiated liposarcoma (DDLS) has a relatively poor prognosis, however this neoplasm rarely occurs in the head and neck. To date, no definite protocol has been established for the diagnosis and treatment of head and neck DDLS. The present study reports the case of a 69-year-old male patient with DDLS of the oral floor. To the best of our knowledge, this is the first documented case of oral floor DDLS. In addition, this is the first reported case with the development of a second primary malignancy following the treatment of head and neck DDLS...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29738363/pancreatic-lipomatous-hamartoma-a-hitherto-unrecognized-variant
#13
Mariko Tanaka, Tetsuo Ushiku, Masako Ikemura, Yutaka Takazawa, Toru Igari, Michio Shimizu, Hiroshi Yamaguchi, Noriyoshi Fukushima, Kei Sakuma, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Takeyuki Watadani, Yousuke Nakai, Kazuhiko Koike, Masashi Fukayama
Pancreatic masses consisting of lipomatous components clinically include lipoma, liposarcoma, lipomatous pseudohypertrophy of the pancreas, fat-containing neoplasms such as perivascular epithelioid cell tumor, and malignant neoplasm with lipoid degeneration. We present pancreatic lipomatous hamartoma, which has not been reported hitherto. A solid pancreatic mass was detected from a computed tomographic scan check-up in each of 3 cases of Japanese men. Macroscopically, well-demarcated solid lipomatous masses were detected at the uncus, body, and tail of the pancreas, respectively...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738182/-epididymal-liposarcoma-with-metastases-to-the-retroperitoneal-space-and-peritoneal-cavity-a-case-report-and-literature-review
#14
Jun-Long Li, Jie Fan
Objective: To report a rare case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity for the purpose of improving the diagnosis and treatment of the disease. METHODS: We retrospectively analyzed the clinical data about a case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity, reviewed relevant literature at home and abroad, and investigated the presentation, diagnosis and treatment of the disease...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29734868/para-anal-lipoma-as-a-rare-consequence-to-perineal-trauma-case-report-and-review-of-the-literature
#15
Ewelina Uscilowska, Nora Abbes Orabi, Daniel Léonard, Anne Mourin-Jouret, Louis Libbrecht, Pierre Trefois, Marie-Armelle Denis, Radu Bachmann, Christophe Remue, Alex Kartheuser
INTRODUCTION: Lipomas are the most common benign mesenchymal tumors which can be found in any part of the body. Nevertheless, their etiology and pathogenesis remain unknown. It is hypothesized that some of these lesions could result from an acute or chronic trauma. PATIENTS AND METHODS: We report a case of a 54-year-old man presenting a perineal lipoma which volume grew rapidly after he fell on his buttock, in the context of inaugural epileptic seizure. Pelvic MRI showed a voluminous fatty mass, measuring 6...
May 7, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29731994/trabectedin-modulates-the-senescence-associated-secretory-phenotype-and-promotes-cell-death-in-senescent-tumor-cells-by-targeting-nf-%C3%AE%C2%BAb
#16
Simona Camorani, Laura Cerchia, Monica Fedele, Eugenio Erba, Maurizio D'Incalci, Elvira Crescenzi
Therapy-induced senescence is a major cellular response to chemotherapy in solid tumors. Senescent tumor cells acquire a secretory phenotype, or SASP, and produce pro-inflammatory factors, whose expression is largely under NF-κB transcriptional control. Secreted factors play a positive role in driving antitumor immunity, but also exert negative influences on the microenvironment, and promote tumor growth and metastasis. Moreover, subsets of cancer cells can escape the senescence arrest, driving tumor recurrence after treatments...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731991/targeted-next-generation-sequencing-of-well-differentiated-dedifferentiated-liposarcoma-reveals-novel-gene-amplifications-and-mutations
#17
Neeta Somaiah, Hannah C Beird, Andrea Barbo, Juhee Song, Kenna R Mills Shaw, Wei-Lien Wang, Karina Eterovic, Ken Chen, Alexander Lazar, Anthony P Conley, Vinod Ravi, Patrick Hwu, Andrew Futreal, George Simon, Funda Meric-Bernstam, David Hong
Well-differentiated/dedifferentiated liposarcoma is a common soft tissue sarcoma with approximately 1500 new cases per year. Surgery is the mainstay of treatment but recurrences are frequent and systemic options are limited. 'Tumor genotyping' is becoming more common in clinical practice as it offers the hope of personalized targeted therapy. We wanted to evaluate the results and the clinical utility of available next-generation sequencing panels in WD/DD liposarcoma. Patients who had their tumor sequenced by either FoundationOne ( n = 13) or the institutional T200/T200...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730066/semi-automated-segmentation-of-the-tumor-vasculature-in-contrast-enhanced-ultrasound-data
#18
Benjamin Theek, Tatjana Opacic, Twan Lammers, Fabian Kiessling
The vascular architecture in tumors contains relevant information for tumor classification and evaluation of therapy responses. To develop a reliable and user-independent analysis tool, a foreground detection algorithm was combined with a maximum-intensity projection to obtain a high signal-to-noise image from contrast-enhanced B-mode data sets, enabling vessel segmentation by thresholding. Parameters describing the density of the vascular network, the number of vessels and the number of branches were extracted...
May 2, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29725455/alternative-lengthening-of-telomeres-phenotype-and-loss-of-atrx-expression-in-sarcomas
#19
REVIEW
Xiaolei Ren, Chao Tu, Zhenchu Tang, Ruofei Ma, Zhihong Li
Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently associated with α-thalassemia syndrome. Cancer cells depend on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative programmed mortality...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29723411/the-clinical-behavior-of-well-differentiated-liposarcoma-can-be-extremely-variable-a-retrospective-cohort-study-at-a-major-sarcoma-center
#20
Emily Z Keung, Naruhiko Ikoma, Robert Benjamin, Wei-Lien Wang, Alexander J Lazar, Barry W Feig
BACKGROUND: The pathogenesis of well differentiated liposarcoma (WDLPS) is poorly understood and pathologic characterization is often challenging. Descriptive terms (such as sclerosing, myxoid, inflammatory, spindle cell) are frequently encountered in the pathology reports and are of unknown clinical significance. METHODS: Sixty-two patients with primary retroperitoneal WDLPS resected at our institution were identified (1996-2011). Pathology reports of surgical resection specimens were retrospectively reviewed and descriptive qualifiers to the WDLPS diagnosis noted...
May 3, 2018: Journal of Surgical Oncology
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