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https://www.readbyqxmd.com/read/29327940/the-different-faces-of-renal-angiomyolipomas-on-radiologic-imaging-a-pictorial-review
#1
Shanigarn Thiravit, Wanwarang Teerasamit, Phakphoom Thiravit
Renal angiomyolipoma (AML) is an uncommon renal tumour, generally composed of mature adipose tissue, dysmorphic blood vessels, and smooth muscle. Identification of intratumoural fat on unenhanced CT images (UECT) is the most reliable finding for establishing the diagnosis of renal AML. However, AMLs sometimes exhibit atypical findings, including cystic as well as solid forms; some of these variants overlap with the appearance of other renal tumours. A rare type of AML, the epithelioid type, possesses malignant potential...
January 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29309298/clarifying-the-distinction-between-malignant-peripheral-nerve-sheath-tumor-and-dedifferentiated-liposarcoma-a-critical-reappraisal-of-the-diagnostic-utility-of-mdm2-and-h3k27me3-status
#2
Naohiro Makise, Masaya Sekimizu, Takashi Kubo, Susumu Wakai, Nobuyoshi Hiraoka, Motokiyo Komiyama, Masashi Fukayama, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
Malignant peripheral nerve sheath tumor (MPNST) and dedifferentiated liposarcoma (DDLPS) are 2 major types of pleomorphic spindle cell sarcoma. The differentiation of MPNST and DDLPS by histomorphology alone can be problematic. Although MDM2 amplification and PRC2 alteration leading to H3K27me3 deficiency are genetic hallmarks of DDLPS and MPNST, respectively, a small number of MDM2-amplified MPNSTs and H3K27me3-deficient DDLPSs have been reported in the literature. We systematically compared MDM2 and H3K27me3 status in 68 MPNSTs and 47 DDLPSs...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29307627/dedifferentiated-liposarcoma-composed-predominantly-of-rhabdoid-epithelioid-cells-a-frequently-misdiagnosed-highly-aggressive-variant
#3
Abbas Agaimy, Michael Michal, Ladislav Hadravsky, Michal Michal
Dedifferentiated liposarcoma is one of the most common sarcoma types in adults with a predilection for the retroperitoneum. We have recently encountered 6 cases of DDL composed predominantly of rounded, rhabdoid or epithelioid cells mimicking rhabdoid melanoma, epithelioid rhabdomyosarcoma or undifferentiated carcinoma. Patients were 5 males and one female aged 64 to 81 years (median, 68). Tumors originated in the retroperitoneum (n=5; 3 in the psoas muscle) and deep soft tissue of the thigh (n=1). All 3 patients with follow-up died of metastatic disease within 4 to 8 months...
January 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29303371/the-management-of-deep-seated-low-grade-lipomatous-lesions
#4
Zeid Al-Ani, Malee Fernando, Victoria Wilkinson, Nikhil Kotnis
Deep-seated, low grade lipomatous lesions detected on imaging often cause uncertainty for diagnosis and treatment. Confidently distinguishing lipomas from well-differentiated liposarcomas (WDL) is often not possible on imaging. The approach to management of such lesions varies widely between institutions. Applying an evidenced-based approach set around published literature that clearly highlights how criteria such as lesion size, location, age and imaging features can be used to predict the risk of WDL and subsequent de-differentiation would seem sensible...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29300200/lipoblastoma-like-tumor-of-the-vulva-an-important-benign-mimic-of-myxoid-liposarcoma
#5
David Creytens
No abstract text is available yet for this article.
January 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29280411/the-potential-of-the-cmb305-vaccine-regimen-to-target-ny-eso-1-and-improve-outcomes-for-synovial-sarcoma-and-myxoid-round-cell-liposarcoma-patients
#6
Seth M Pollack
Synovial Sarcoma (SS) and Myxoid Round Cell Liposarcoma (MRCL) are devastating sarcoma subtypes with few treatment options and poor outcomes in the advanced setting. However, both these diseases may be ideal for novel immunotherapies targeting the cancer-testis antigen, NY-ESO-1. Areas covered: In this review, we discuss the novel NY-ESO-1 targeted vaccine regimen, CMB305. This regimen uses a unique integration-deficient, dendritic-cell targeting lentiviral vector from the ZVex® platform, LV305, in order to prime NY-ESO-1 specific T cells...
December 27, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29279582/histopathological-diagnoses-in-soft-tissue-tumours-an-experience-from-a-tertiary-centre-in-malaysia
#7
N D Jalaludin, N Mohd Dusa, M R Hassan, N Abd Shukor
Soft tissue tumours are a group of remarkably diverse neoplasms that frequently pose significant diagnostic challenges to general pathologists. This study aimed to compare the agreement of histopathological diagnoses between general pathologists from various referral institutes and the referred soft tissue pathologist in a tertiary centre. The common discrepancies and their causes are also presented here. A retrospective study was conducted on 243 cases of potential soft tissue tumours referred to Hospital Kuala Lumpur, Malaysia over a period of 5 years...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279323/the-hidden-genomic-and-transcriptomic-plasticity-of-giant-marker-chromosomes-in-cancer
#8
Gemma Macchia, Marco Severgnini, Stefania Purgato, Doron Tolomeo, Hilen Casciaro, Ingrid Cifola, Alberto L'Abbate, Anna Loverro, Orazio Palumbo, Massimo Carella, Laurence Bianchini, Giovanni Perini, Gianluca De Bellis, Fredrik Mertens, Mariano Rocchi, Clelia T Storlazzi
Genome amplification in the form of rings or giant rod-shaped marker chromosomes is a common genetic alteration in soft tissue tumours. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to cancer progression. Here, we disentangled the genomic architecture of many neocentromeres stabilizing marker chromosomes in well-differentiated liposarcoma and lung sarcomatoid carcinoma samples. In cells carrying heavily rearranged RGMs, these structures were assembled as patchworks of multiple short amplified sequences, disclosing an extremely high level of complexity and definitely ruling out the existence of regions prone to the neocentromere seeding...
December 26, 2017: Genetics
https://www.readbyqxmd.com/read/29275455/early-detection-of-metastases-using-whole-body-mri-for-initial-staging-and-routine-follow-up-of-myxoid-liposarcoma
#9
Natalia Gorelik, Santhosh Mauvva Venkatesh Reddy, Robert E Turcotte, Krista Goulding, Sungmi Jung, Thierry Alcindor, Thomas I Powell
OBJECTIVE: To define the role of whole-body MRI (WBMRI) for initial staging and routine follow-up of myxoid liposarcoma (MLS). MATERIALS AND METHODS: A retrospective review of all the patients with MLS who underwent WBMRI for initial staging and routine follow-up at our institution between October 1, 2006, and September 30, 2016 was performed. Patient demographics, clinical presentation, imaging findings, tumor histology, and occurrence and location of metastatic disease were recorded...
December 23, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29273375/the-impact-of-lipomatous-tumors-on-type-2-diabetes-are-adipose-derived-tumors-metabolically-active
#10
Fedra Fallahian, Ali Ardestani, Elisha Pranckevicius, Chandrajit P Raut, Ali Tavakkoli, Eric G Sheu
BACKGROUND: The metabolic and immunologic properties of adipose tissue are linked to the pathogenesis of type 2 diabetes mellitus. Lipomatous tumors, such as liposarcomas, are rare but can reach significant size. We hypothesized that some lipomatous tumors are metabolically active and can alter systemic glucose homeostasis. METHODS: We performed a retrospective study of patients who underwent resection of a lipomatous tumor at a tertiary cancer referral center (2004-2015)...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29250486/systemic-therapy-in-metastatic-or-unresectable-well-differentiated-dedifferentiated-liposarcoma
#11
REVIEW
Yevette McGovern, Charlie D Zhou, Robin L Jones
Liposarcoma is one of the most common subtypes of soft-tissue sarcoma and consists of three main subtypes, of which well-differentiated liposarcoma and dedifferentiated liposarcoma account for 40-45%. The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting. Recently, eribulin and trabectedin have been approved by the US Food and Drug Administration for recurrent liposarcomas and progress in molecular characterization of these tumors has opened up new and potential novel treatment targets...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29249787/-anterior-mediastinal-myxoid-liposarcoma-detected-by-chest-computed-tomogram-in-the-patient-with-pneumothorax
#12
Shinji Nakashima, Toshiyuki Maeda, Satoshi Muraki, Taku Sakurada, Jun Sasaki, Eiji Araki, Hisayoshi Osawa, Atsushi Watanabe
A 57-year-old woman visited our hospital with left chest pain. Chest computed tomography (CT) scanning showed left pneumothorax with apical bullae and a nodular shadow in the left anterior mediastinum accidentally. However, a week later, we could not detect a mediastinal shadow on chest CT image after healing of left pneumothorax. Video assisted thoracoscopic surgery was scheduled in order to remove bullae and evaluate an anterior mediastinal lesion. The mediastinal lesion was tumorous and resected with around pericardial fat tissue...
December 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29247978/advances-in-chromosomal-translocations-and-fusion-genes-in-sarcomas-and-potential-therapeutic-applications
#13
REVIEW
Xin Xiao, Cassandra C Garbutt, Francis Hornicek, Zheng Guo, Zhenfeng Duan
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in different tumors are due to the advancement of next-generation sequencing (NGS) technologies such as whole genome sequencing. Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches...
December 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#14
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29234568/long-term-quality-of-life-of-retroperitoneal-sarcoma-patients-treated-with-pre-operative-radiotherapy-and-surgery
#15
Philip Wong, Zahra Kassam, Amanda N Springer, Rebecca Gladdy, Peter Chung, Jolie Ringash, Charles Catton
PURPOSE: Retroperitoneal sarcomas (RPS) are connective tissue cancers that are often large and anatomically in close proximity to critical and radiation-sensitive normal structures and organs within the abdomen and pelvis. The management of RPS may include preoperative radiotherapy (RT) and surgery. We aimed to examine how treatment-related toxicities affect patient quality of life (QOL).  Methods and materials: Within two prospective cohort studies, 48 RPS patients who were treated with preoperative RT from 1998-2012 were recruited and assessed for QOL (EORTC-QLQ-C30) and to determine toxicities potentially related to RT and surgery (graded using CTCAE V...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29233581/giant-esophageal-liposarcoma-in-asymptomatic-young-patient
#16
Ana Rodríguez Pérez, Natalia Pérez Serrano, Aitana García Tejero, Blanca Escudero Nalda, Rafael Gil Albarellos
No abstract text is available yet for this article.
December 9, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29228466/concomitant-organ-resection-does-not-improve-outcomes-in-primary-retroperitoneal-well-differentiated-liposarcoma-a-retrospective-cohort-study-at-a-major-sarcoma-center
#17
Naruhiko Ikoma, Christina L Roland, Keila E Torres, Yi-Ju Chiang, Wei-Lien Wang, Neeta Somaiah, Gary N Mann, Kelly K Hunt, Janice N Cormier, Barry W Feig
BACKGROUND: We investigated whether concomitant organ removal as part of the primary resection of RP WDLPS confers an outcome advantage in patients treated at a major sarcoma center. METHODS: The departmental sarcoma database was reviewed to identify patients with RP WDLPS who underwent initial surgical resection for primary disease at MD Anderson Cancer Center during the study period 1995-2011. We retrospectively reviewed medical records and examined associations between clinicopathologic variables and overall survival (OS) as well as disease-free survival (DFS)...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29228461/imaging-of-liposarcomas-for-clinicians-characteristic-features-and-differential-considerations
#18
REVIEW
Oluwadamilola Teniola, Kevin Yuqi Wang, Wei-Lien Wang, WilliamW Tseng, Behrang Amini
Liposarcoma (LPS) is a malignancy of fat and one of the most common soft tissue sarcomas. There are three major subtypes of LPS: Well-differentiated / dedifferentiated, myxoid, and pleomorphic. We review the imaging features of LPS in the abdomen and extremities, describe features that help differentiate the subtypes, and provides alternative considerations for fat-containing lesions (many benign) that can mimic LPS.
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29225876/asymptomatic-giant-retroperitoneal-mass-detected-at-a-medical-checkup
#19
Tsutomu Takeda, Daisuke Asaoka, Yuki Fukumura, Sumio Watanabe
The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosis than other soft tissue sarcomas. Soft tissue sarcoma of retroperitoneal origin often remains asymptomatic until tumor enlargement, leading to diagnosis at advanced stages.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29223346/-combination-of-left-atrial-myxoma-and-retrocardiac-liposarcoma-with-right-atrial-infiltration
#20
Alejandra Rodríguez-Hernández, Francisco Martín Baranda-Tovar
No abstract text is available yet for this article.
December 6, 2017: Archivos de Cardiología de México
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