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Keywords Corticotropin releasing and ad...

Corticotropin releasing and addiction

https://read.qxmd.com/read/35503756/corticotropin-releasing-factor-crf-systems-promoting-cocaine-pursuit-without-distress-via-incentive-motivation
#21
JOURNAL ARTICLE
Hannah M Baumgartner, Madeliene Granillo, Jay Schulkin, Kent C Berridge
Corticotropin releasing factor (CRF) systems in limbic structures are posited to mediate stress-induced relapse in addiction, traditionally by generating distress states that spur drug consumption as attempts at hedonic self-medication. Yet evidence suggests that activating CRF-expressing neurons in the central amygdala (CeA) or nucleus accumbens (NAc) can magnify incentive motivation in absence of distress, at least for sucrose rewards. However, traditional CRF hypotheses in addiction neuroscience are primarily directed toward drug rewards...
2022: PloS One
https://read.qxmd.com/read/35487273/regulation-of-alcohol-drinking-by-ventral-striatum-and-extended-amygdala-circuitry
#22
REVIEW
Marissa B Borrego, Amy E Chan, Angela R Ozburn
Alcohol use disorder is a complex psychiatric disorder that can be modeled in rodents using a number of drinking paradigms. Drinking-in-the-dark (DID) is widely used to model the binge/intoxication stage of addiction, and chronic intermittent ethanol vapor procedures (CIE) are used to induce dependence and model withdrawal/negative affect induced escalation of drinking. We discuss experiments showing the ventral striatum (vStr) and extended amygdala (EA) are engaged in response to ethanol in rodents through c-Fos/Fos immunoreactivity studies...
July 1, 2022: Neuropharmacology
https://read.qxmd.com/read/35085692/hpa-axis-dysfunction-during-morphine-withdrawal-in-offspring-of-female-rats-exposed-to-opioids-preconception
#23
JOURNAL ARTICLE
Fair M Vassoler, Sara B Isgate, Kerri E Budge, Elizabeth M Byrnes
Opioid use and abuse remain a significant public health problem, particularly in the United States. Indeed, it is estimated that up to 10% of youths (age 12-18) have taken opioids illicitly. A growing body of evidence suggests that this level of widespread opioid exposure can have effects that extend to subsequent generations. Utilizing a well-established rodent model of preconception adolescent opioid exposure in females, we found decreased opioid self-administration coupled with increased cocaine self-administration in adult offspring...
March 16, 2022: Neuroscience Letters
https://read.qxmd.com/read/34924971/the-antagonism-of-corticotropin-releasing-factor-receptor-1-in-brain-suppress-stress-induced-propofol-self-administration-in-rats
#24
JOURNAL ARTICLE
Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin Wu
Propofol addiction has been detected in humans and rats, which may be facilitated by stress. Corticotropin-releasing factor acts through the corticotropin-releasing factor (CRF) receptor-1 (CRF1R) and CRF2 receptor-2 (CRF2R) and is a crucial candidate target for the interaction between stress and drug abuse, but its role on propofol addiction remains unknown. Tail clip stressful stimulation was performed in rats to test the stress on the establishment of the propofol self-administration behavioral model. Thereafter, the rats were pretreated before the testing session at the bilateral lateral ventricle with one of the doses of antalarmin (CRF1R antagonist, 100-500 ng/site), antisauvagine 30 (CRF2R antagonist, 100-500 ng/site), and RU486 (glucocorticoid receptor antagonist, 100-500 ng/site) or vehicle...
2021: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/34912198/corticotropin-releasing-factor-binding-protein-as-a-novel-target-to-restore-brain-homeostasis-lessons-learned-from-alcohol-use-disorder-research
#25
REVIEW
Dallece E Curley, Ashley E Webb, Douglas J Sheffler, Carolina L Haass-Koffler
Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative disease. The physio-pathology of stress is regulated by the corticotropin-releasing factor (CRF) system, the upstream component of the hypothalamic-pituitary-adrenal (HPA) axis. Extensive literature has shown that dysregulation of the CRF neuroendocrine system contributes to escalation of alcohol consumption and, similarly, chronic alcohol consumption contributes to disruption of the stress system...
2021: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/34901719/the-role-of-the-corticotropin-releasing-hormone-and-its-receptors-in-the-regulation-of-stress-response
#26
JOURNAL ARTICLE
E V Sukhareva
Stress is an essential part of everyday life. The neuropeptide corticotropin-releasing hormone (CRH, also called CRF and corticoliberin) plays a key role in the integration of neuroendocrine, autonomic and behavioral responses to stress. The activation of the hypothalamic-pituitary-adrenal axis (HPA axis) by neurons of the paraventricular hypothalamic nucleus (PVN), the primary site of synthesis CRH, triggers stress reactions. In addition to the hypothalamus, CRH is widespread in extrahypothalamic brain structures, where it functions as a neuromodulator for coordination and interaction between the humoral and behavioral aspects of a stress response...
March 2021: Vavilovskii Zhurnal Genetiki i Selektsii
https://read.qxmd.com/read/34856350/design-synthesis-structural-optimization-sar-in-silico-prediction-of-physicochemical-properties-and-pharmacological-evaluation-of-novel-potent-thiazolo-4-5-d-pyrimidine-corticotropin-releasing-factor-crf-receptor-antagonists
#27
JOURNAL ARTICLE
Md Rabiul Islam, Mohamed Teleb, Vlasios Karageorgos, Stelios Sakellaris, Minas Papadopoulos, Ioannis Pirmettis, Frank R Fronczek, George Liapakis, Hesham Fahmy
Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide secreted from the hypothalamus and is the main regulator of the hypothalamus-pituitary-adrenocortical (HPA) axis. CRF is the master hormone which modulates physiological and behavioral responses to stress. Many disorders including anxiety, depression, addictive disorders and others are related to over activation of the CRF system. This suggests that new molecules which can interfere with CRF binding to its receptors may be potential candidates for neuropsychiatric drugs to treat stress-related disorders...
February 1, 2022: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/34856204/at-the-heart-of-the-interoception-network-influence-of-the-parasubthalamic-nucleus-on-autonomic-functions-and-motivated-behaviors
#28
REVIEW
Tanvi Shah, Jeffery L Dunning, Candice Contet
The parasubthalamic nucleus (PSTN), a small nucleus located on the lateral edge of the posterior hypothalamus, has emerged in recent years as a highly interconnected node within the network of brain regions sensing and regulating autonomic function and homeostatic needs. Furthermore, the strong integration of the PSTN with extended amygdala circuits makes it ideally positioned to serve as an interface between interoception and emotions. While PSTN neurons are mostly glutamatergic, some of them also express neuropeptides that have been associated with stress-related affective and motivational dysfunction, including substance P, corticotropin-releasing factor, and pituitary adenylate-cyclase activating polypeptide...
February 15, 2022: Neuropharmacology
https://read.qxmd.com/read/34825430/repeated-cocaine-or-methamphetamine-treatment-alters-astrocytic-crf2-and-glast-expression-in-the-ventral-midbrain
#29
JOURNAL ARTICLE
Amanda L Sharpe, Marta Trzeciak, Nicole L Eliason, Harris E Blankenship, Bre' Ana M Byrd, Phillip D Douglas, Willard M Freeman, Michael J Beckstead
Dopamine neurons in the substantia nigra (SN) and ventral tegmental area (VTA) play a central role in the reinforcing properties of abused drugs including methamphetamine and cocaine. Chronic effects of psychostimulants in the SN/VTA also involve non-dopaminergic transmitters, including glutamate and the stress-related peptide corticotropin-releasing factor (CRF). In the SN/VTA, astrocytes express a variety of membrane-bound neurotransmitter receptors and transporters that influence neurotransmission. CRF receptor type 2 (CRF2) activity in the VTA is important for stress-induced relapse and drug-seeking behaviour, but the localization of its effects is incompletely understood...
November 25, 2021: Addiction Biology
https://read.qxmd.com/read/34801172/early-life-stress-and-susceptibility-to-addiction-in-adolescence
#30
REVIEW
K E Tschetter, L B Callahan, S A Flynn, S Rahman, T P Beresford, P J Ronan
Early life stress (ELS) is a risk factor for developing a host of psychiatric disorders. Adolescence is a particularly vulnerable period for the onset of these disorders and substance use disorders (SUDs). Here we discuss ELS and its effects in adolescence, especially SUDs, and their correlates with molecular changes to signaling systems in reward and stress neurocircuits. Using a maternal separation (MS) model of neonatal ELS, we studied a range of behaviors that comprise a "drug-seeking" phenotype. We then investigated potential mechanisms underlying the development of this phenotype...
2022: International Review of Neurobiology
https://read.qxmd.com/read/34624301/corticotropin-releasing-factor-and-norepinephrine-related-circuitry-changes-in-the-bed-nucleus-of-the-stria-terminalis-in-stress-and-alcohol-and-substance-use-disorders
#31
REVIEW
Angela E Snyder, Yuval Silberman
Alcohol Use Disorder (AUD) affects around 14.5 million individuals in the United States, with Substance Use Disorder (SUD) affecting an additional 8.3 million individuals. Relapse is a major barrier to effective long-term treatment of this illness with stress often described as a key trigger for a person with AUD or SUD to relapse during a period of abstinence. Two signaling molecules, norepinephrine (NE) and corticotropin releasing factor (CRF), are released during the stress response, and also play important roles in reward behaviors and the addiction process...
December 15, 2021: Neuropharmacology
https://read.qxmd.com/read/34384845/anthocyanins-in-lycium-ruthenicum-murray-reduce-nicotine-withdrawal-induced-anxiety-and-craving-in-mice
#32
JOURNAL ARTICLE
Jing Luo, Li-Hua Bian, Zi-Wei Yao, Xiao-Mei Wang, Qiu-Yu Li, Jian-You Guo, Jin-Li Shi
Lycium ruthenicum Murray is widely used in traditional Chinese medicine and is believed to have antimicrobial, antioxidant, and anti-fatigue effects. Anthocyanins are considered to be one of the main active components. The previous work by our research team found that the anthocyanins in Lycium ruthenicum extract (ALRM) produce a stable anti-anxiety effect. The mechanisms of action include reducing the level of corticotropin-releasing factor (CRF) as well as regulating extracellular signal-regulated kinase/mitogen activation, protein kinase (ERK/MAPK) pathways, and others, all of which are related to the mechanisms of nicotine addiction...
October 15, 2021: Neuroscience Letters
https://read.qxmd.com/read/34075665/sex-specific-plasticity-in-crf-regulation-of-inhibitory-control-in-central-amygdala-crf1-neurons-after-chronic-voluntary-alcohol-drinking
#33
JOURNAL ARTICLE
Abigail E Agoglia, ManHua Zhu, Sema G Quadir, Maya N Bluitt, Eliza Douglass, Tyger Hanback, Jyoshitha Tella, Rose Ying, Clyde W Hodge, Melissa A Herman
Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may limit the translation of preclinical CRF1 research to patients, including reliance on experimenter-administered alcohol instead of voluntary consumption, a preponderance of evidence collected in male subjects only and an inability to assess the effects of alcohol on specific brain circuits...
June 2, 2021: Addiction Biology
https://read.qxmd.com/read/33961872/time-dependent-changes-in-striatal-monoamine-levels-and-gene-expression-following-single-and-repeated-amphetamine-administration-in-rats
#34
JOURNAL ARTICLE
Andrey Sequeira-Cordero, Juan C Brenes
As drug addiction may result from pathological usurpations of learning and memory's neural mechanisms, we focused on the amphetamine-induced time-dependent neurochemical changes associated with neural plasticity. We used juvenile rats as the risk for drug abuse is higher during adolescence. Experiment 1 served to define the appropriate amphetamine dose and the neurochemical effects of a single administration. In experiment 2, rats received seven amphetamine or saline injections in the open-field test throughout a twelve-day period...
August 5, 2021: European Journal of Pharmacology
https://read.qxmd.com/read/33919862/acupuncture-alleviates-anxiety-and-22-khz-ultrasonic-vocalizations-in-rats-subjected-to-repeated-alcohol-administration-by-modulating-the-brain-derived-neurotrophic-factor-corticotropin-releasing-hormone-signaling-pathway
#35
JOURNAL ARTICLE
Su Yeon Seo, Se Kyun Bang, Suk Yun Kang, Seong Jin Cho, Kwang Ho Choi, Yeon Hee Ryu
The Shenmen point (acupuncture point heart 7: HT7), located in the heart meridian, is frequently used to treat mental disorders, including drug addiction, anxiety, and depression. This study aimed to determine how HT7 regulates anxiety and negative emotions caused by repeated alcohol administration, focusing on the amygdala and paraventricular nucleus (PVN). Repeated administration of alcohol (ETOH; 2 g/kg, i.p. injection, 16% v / v ) for 14 days increased the corticosterone (CORT) levels, and HT7 stimulation reduced the plasma CORT levels...
April 14, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33867924/corticotropin-releasing-hormone-signaling-in-the-bed-nuclei-of-the-stria-terminalis-as-a-link-to-maladaptive-behaviors
#36
REVIEW
Claire Emily Young, Qingchun Tong
The bed nuclei of the stria terminalis (BST) is a limbic region in the extended amygdala that is heavily implicated in anxiety processing and hypothalamic-adrenal-pituitary (HPA) axis activation. The BST is complex, with many nuclei expressing different neurotransmitters and receptors involved in a variety of signaling pathways. One neurotransmitter that helps link its functions is corticotropin releasing hormone (CRH). BST CRH neuron activation may cause both anxiogenic and anxiolytic effects in rodents, and CRH neurons interact with other neuron types to influence anxiety-like responses as well as alcohol and drug-seeking behavior...
2021: Frontiers in Neuroscience
https://read.qxmd.com/read/33726937/activating-corticotropin-releasing-factor-systems-in-the-nucleus-accumbens-amygdala-and-bed-nucleus-of-stria-terminalis-incentive-motivation-or-aversive-motivation
#37
JOURNAL ARTICLE
Hannah M Baumgartner, Jay Schulkin, Kent C Berridge
BACKGROUND: Corticotropin-releasing factor (CRF) neural systems are important stress mechanisms in the central amygdala (CeA), bed nucleus of stria terminalis (BNST), nucleus accumbens (NAc), and related structures. CRF-containing neural systems are traditionally posited to generate aversive distress states that motivate overconsumption of rewards and relapse in addiction. However, CRF-containing systems may alternatively promote incentive motivation to increase reward pursuit and consumption without requiring aversive states...
January 21, 2021: Biological Psychiatry
https://read.qxmd.com/read/33704789/neurobiology-of-alcohol-seeking-behavior
#38
REVIEW
Esi Domi, Ana Domi, Louise Adermark, Markus Heilig, Eric Augier
Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse consequences. A main challenge of addiction treatment is to prevent relapse, which occurs in more than >50% of newly-abstinent patients with alcohol disorder within 3 months. In people suffering from alcohol addiction, stressful events, drug-associated cues and contexts, or re-exposure to a small amount of alcohol trigger a chain of behaviors that frequently culminates in relapse...
March 11, 2021: Journal of Neurochemistry
https://read.qxmd.com/read/33673448/oxytocin-signaling-as-a-target-to-block-social-defeat-induced-increases-in-drug-abuse-reward
#39
REVIEW
Carmen Ferrer-Pérez, Marina D Reguilón, José Miñarro, Marta Rodríguez-Arias
There is huge scientific interest in the neuropeptide oxytocin (OXT) due to its putative capacity to modulate a wide spectrum of physiological and cognitive processes including motivation, learning, emotion, and the stress response. The present review seeks to increase the understanding of the role of OXT in an individual's vulnerability or resilience with regard to developing a substance use disorder. It places specific attention on the role of social stress as a risk factor of addiction, and explores the hypothesis that OXT constitutes a homeostatic response to stress that buffers against its negative impact...
February 27, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33671048/dysregulation-of-nociceptin-orphanin-fq-and-dynorphin-systems-in-the-extended-amygdala-of-alcohol-preferring-marchigian-sardinian-msp-rats
#40
JOURNAL ARTICLE
Francesca Felicia Caputi, Serena Stopponi, Laura Rullo, Martina Palmisano, Massimo Ubaldi, Sanzio Candeletti, Roberto Ciccocioppo, Patrizia Romualdi
Previous studies have shown that genetically selected Marchigian Sardinian alcohol-preferring (msP) rats consume excessive amounts of ethanol to self-medicate from negative moods and to relieve innate hypersensitivity to stress. This phenotype resembling a subset of alcohol use disorder (AUD) patients, appears to be linked to a dysregulation of the equilibrium between stress and antistress mechanisms in the extended amygdala. Here, comparing water and alcohol exposed msP and Wistar rats we evaluate the transcript expression of the anti-stress opioid-like peptide nociceptin/orphanin FQ (N/OFQ) and its receptor NOP as well as of dynorphin (DYN) and its cognate κ-opioid receptor (KOP)...
February 28, 2021: International Journal of Molecular Sciences
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