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Limb salvage

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https://www.readbyqxmd.com/read/29030830/function-and-quality-of-life-among-primary-osteosarcoma-survivors-in-iran-amputation-versus-limb-salvage
#1
S Solooki, S M Mostafavizadeh Ardestani, H Mahdaviazad, B Kardeh
PURPOSE: This study aimed to evaluate the psychometric properties of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in Iranian osteosarcoma patients and apply this to compare the functional level, quality of life, symptoms and financial burden of the patients who underwent amputation and limb-salvage operations. METHODS: This study was conducted at the main referral orthopedic centers in the southwest of Iran from 2006 to 2016...
October 13, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29025216/assisted-salvage-of-ischemic-fasciocutaneous-flap-using-adipose-derived-mesenchymal-stem-cells-in-situ-revascularization
#2
Michael H Carstens, Mauricio Mendieta, Cecilia Pérez, Esperanza Villareal, Rodolfo Garcia
Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia. We will show that this concept can be applied to augment blood flow in zones of flap ischemia. We presented a case study of a 26-year-old man with a complex hand injury covered by a reverse radial perforator fasciocutaneous flap, which developed ischemic necrosis and was treated by debridement, transplantation of ASCs to enhance vascular support, and saline dressings...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29022281/isolated-limb-perfusion-and-infusion-for-extremity-soft-tissue-sarcoma-a-contemporary-systematic-review-and-meta-analysis
#3
Madalyn G Neuwirth, Yun Song, Andrew J Sinnamon, Douglas L Fraker, Jonathan S Zager, Giorgos C Karakousis
BACKGROUND: Isolated limb perfusion (ILP) and isolated limb infusion (ILI) have been variably used in recent years for the treatment of locally advanced or marginally resectable extremity soft tissue sarcomas (STSs). We performed a systematic review and meta-analysis of contemporary studies to further characterize treatment patterns and outcomes. METHODS: PubMed was queried for articles published in or after the year 2000, in the English language, with > 10 patients, and with adequate outcome data following ILP/ILI...
October 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29021882/primary-osteosarcoma-of-the-distal-fibula-treated-with-distal-fibulectomy-with-a-five-year-follow-up-a-case-report
#4
I Saadon, B Amit, A Zolquarnian, F Muhamad
Musculoskeletal tumours of the lower limbs especially malignant tumours are not common. The fibula is the site of primary bone tumours as reported in 2.4% of lower limb tumours with the proximal third being more frequently involved than the distal segment. Osteosarcoma is the most common primary malignant bone tumour of nonhaematopoietic origin, with distal fibular involvement in 0.47% of patients. The advances in imaging techniques and neo-adjuvant chemotherapy have now made it possible to accurately define the extent of tumour and plan limb salvage with tumour resection...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29021730/case-report-of-a-high-voltage-electrical-injury-and-review-of-the-indications-for-early-fasciotomy-in-limb-salvage-of-an-electrically-injured-limb
#5
T J Huei, S J Mohd Yussof, H T C Lip, I Salina
Electrical injuries make up a relatively small portion of burn injuries. Safety measures in place on domestic electricity supply have reduced the occurrence of high voltage electrical injuries. We present the case of a young man who sustained a high voltage electrical injury on all four limbs. Early fasciotomy was performed on both his hands and forearms. Despite early compartment release, the left upper limb deteriorated and required amputation. In this article we discuss the indications, outcomes and complications of early fasciotomy...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29019175/isolated-limb-infusion-a-single-center-experience-with-over-200-infusions
#6
Cristina O'Donoghue, Matthew C Perez, John E Mullinax, Danielle Hardman, Sean Sileno, Syeda Mahrukh Hussnain Naqvi, Youngchul Kim, Ricardo J Gonzalez, Jonathan S Zager
BACKGROUND: Isolated limb infusion (ILI) is a minimally invasive technique for delivering regional chemotherapy to an extremity for patients with locally advanced cutaneous malignancies and sarcoma. METHODS: A single-institution, prospectively collected database was analyzed for intention-to-treat with ILI. RESULTS: From 2007 to 2016, 163 patients underwent 205 procedures (201 were successfully completed), and four malignancies were treated: melanoma (72...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29018173/a-pilot-study-of-surgical-telementoring-for-leg-fasciotomy
#7
Max Talbot, E J Harvey, G K Berry, R Reindl, H Tien, D J Stinner, G Slobogean
INTRODUCTION: Acute extremity compartment syndrome requires rapid decompression. In remote locations, distance, weather and logistics may delay the evacuation of patients with extremity trauma beyond the desired timeline for compartment release. The aim of this study was to establish the feasibility of performing telementored surgery for leg compartment release and to identify methodological issues relevant for future research. METHODS: Three anaethetists and one critical care physician were recruited as operators...
October 10, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28994569/carbon-coated-self-expandable-stents-in-patients-with-atherosclerotic-iliac-artery-disease
#8
Nicola Troisi, Leonardo Ercolini, Emiliano Chisci, Pierfrancesco Frosini, Filippo Turini, Stefano Michelagnoli
BACKGROUND: Aim of this study was to evaluate the safety and effectiveness of carbon-coated self- expandable stents in the revascularization of atherosclerotic iliac artery lesions. METHODS: Between January 2012 and June 2016 54 carbon-coated self-expandable stents (Easy HiFlype and Easy Flype; manufactured by CID S.p.A., a member of Alvimedica Group, Istanbul, Turkey) in 40 patients were implanted in our Center. Early and 2-year outcomes have been evaluated in terms of major morbidity, mortality, primary patency, primary assisted patency, secondary patency, absence of target lesion restenosis (TLR), healing of the lesions/relief of symptoms, and limb salvage...
October 10, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28990681/limb-shortening-as-a-strategy-for-limb-sparing-treatment-of-appendicular-osteosarcoma-of-the-distal-radius-in-a-dog
#9
Sarah E Boston, Owen T Skinner
OBJECTIVE: To develop and report a novel limb sparing technique for the distal radius in a dog. STUDY DESIGN: Case report. ANIMAL: A 14-year-old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full-course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28987672/volume-fractions-of-dce-mri-parameter-as-early-predictor-of-histologic-response-in-soft-tissue-sarcoma-a-feasibility-study
#10
Wei Xia, Zhuangzhi Yan, Xin Gao
OBJECTIVE: To find early predictors of histologic response in soft tissue sarcoma through volume transfer constant (K(trans)) analysis based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: 11 Patients with soft tissue sarcoma of the lower extremity that underwent preoperative chemoradiotherapy followed by limb salvage surgery were included in this retrospective study. For each patient, DCE-MRI data sets were collected before and two weeks after therapy initiation, and histologic tumor cell necrosis rate (TCNR) was reported at surgery...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28986075/the-scope-of-upper-limb-surgery-for-tetraplegics-role-of-tendon-transfers-and-universal-cuff
#11
Mukul Mohindra, Paritosh Gogna, Sukhbir Singh Sangwan, Sahil Gaba, Zile Singh Kundu
OBJECTIVE: The aim of this study was to evaluate the role of tendon transfers and universal cuff in restoring hand function in tetraplegic patients. METHODS: Twenty-one upper limbs on 12 tetraplegic patients (9 males and 3 females); mean age: 42.2 years (range 22-58 years) with a spinal cord injury at or distal to C6, were included in this study. Key pinch was restored using Brachioradialis to Flexor Pollicis Longus transfer and hook using Pronator Teres to Flexor Digitorum Profundus transfer...
October 4, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28985632/limb-and-flap-salvage-in-gustilo-iiic-injuries-treated-by-vascular-repair-and-emergency-free-flap-transfer
#12
Zoran Marij Arnež, Giovanni Papa, Vittorio Ramella, Federico Cesare Novati, Uros Ahcan, Chiara Stocco
No abstract text is available yet for this article.
October 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28979634/delayed-brachial-artery-reconstruction-after-traumatic-injury-a-case-for-sustainment-of-surgical-intervention
#13
Kelechi Emmanuel Okonta, Emmanuel Ossai Ocheli, Tombari Joseph Gbeneol
The brachial artery is the commonest artery injured in the extremities. Although the patients present late, nevertheless reconstructions is advocated in other to salvage the limb and maintain function of the hand. We retrospectively examined 25 consecutive patients with vascular injuries treated at The Cardiovascular and Thoracic Surgery Unit of a tertiary health centre over a period of 4 years. We assessed the pre-tertiary methods of stopping of bleeding injured brachial arteries, mechanisms of injury, associated injuries, treatment and the outcome following vascular repair in terms of functionality of the forearm and the volume of the radial pulsation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28974341/bubr1-insufficiency-impairs-angiogenesis-in-aging-and-in-experimental-critical-limb-ischemic-mice
#14
Jun Okadome, Takuya Matsumoto, Keiji Yoshiya, Daisuke Matsuda, Kouji Tamada, Mitsuho Onimaru, Kaku Nakano, Kensuke Egashira, Yoshikazu Yonemitsu, Yoshihiko Maehara
OBJECTIVES: Budding uninhibited by benzimidazole-related 1 (BubR1), a cell cycle-related protein, is an essential component of the spindle checkpoint that regulates cell division. Mice in which BubR1 expression is reduced to 10% of the normal level display the phenotypic features of progeria. However, the role of BubR1 in vascular diseases and angiogenesis remains unknown. To investigate the influence of BubR1 on angiogenesis, we generated a low-null-BubR1-expressing (BubR1(L/-)) mouse strain with reduced BubR1 expression as low as 15% of the normal level without any abnormalities in appearance...
September 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28969190/groin-flap-in-paediatric-age-group-to-salvage-hand-after-electric-contact-burn-challenges-and-experience
#15
Pradeep Gupta, Rakesh Singh Tawar, Manohar Malviya
INTRODUCTION: Electric contact burn is characterised by multiple wounds produced by entrance and exit of the current. Hand is most commonly involved in the same and children are particularly susceptible to such accidents. AIM: To document effectiveness and challenges associated with the use of groin flap as an initial definitive treatment of electric contact burn in paediatric age group. MATERIALS AND METHODS: From January 2015 to December 2016, 25 children up to 12 years of age, who were admitted at SMS Medical College, Jaipur, Rajasthan, India, after electric burn injury with hand defect and who were treated by pedicled groin flap at the Department of Plastic and Reconstructive Surgery, were included in the study...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965798/evaluation-of-paramalleolar-and-inframalleolar-bypasses-in-dialysis-and-nondialysis-dependent-patients-with-critical-limb-ischemia
#16
Shinsuke Kikuchi, Tadahiro Sasajima, Masashi Inaba, Daiki Uchida, Taku Kokubo, Yukihiro Saito, Atsuhiro Koya, Hisashi Uchida, Nobuyoshi Azuma
OBJECTIVE: The aim of this study was to elucidate the efficacy of paramalleolar or inframalleolar bypass (PIMB) in hemodialysis-dependent (HD) patients with critical limb ischemia (CLI) and nonhemodialysis-dependent (NHD) patients in terms of clinical outcomes. METHODS: Between January 2000 and December 2013, there were 333 consecutive arteriosclerosis obliterans patients with CLI who underwent 401 PIMB procedures for limb salvage (LS). Of the 333 patients, 188 (56...
September 28, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28964617/tibiodistal-vein-bypass-in-critical-limb-ischemia-and-its-role-after-unsuccessful-tibial-angioplasty
#17
Florian K Enzmann, Sebastian K Eder, Thomas Aschacher, Manuela Aspalter, Patrick Nierlich, Klaus Linni, Thomas J Hölzenbein
OBJECTIVE: Technical progress in angioplasty expanded its application to very distal arterial lesions of the lower extremity. In cases of unsuccessful angioplasty tibiodistal bypass surgery may be required for limb salvage. We investigated the long-term outcome of this technique in patients with critical limb ischemia. The purpose of this study was to evaluate whether tibiodistal bypasses done after unsuccessful tibial angioplasty had inferior patency, limb salvage, or survival rates compared with primary tibiodistal bypasses...
September 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28953683/classic-hodgkin-lymphoma-in-pelvis-a-case-report-highlights-diagnosis-and-treatment-challenges
#18
Fan Tang, Li Min, Yunxia Ye, Bo Tang, Yong Zhou, Wenli Zhang, Chongqi Tu
RATIONALE: Classic Hodgkin lymphoma with pelvic involvement is a rare entity. Diagnosis and treatment for such an uncommon disease are challenging. Here we report a special case of classic Hodgkin lymphoma in pelvis. PATIENT CONCERNS: A 20-year-old woman was admitted to our department due to left hip symptoms. The patient reported a history of drenching night sweats, low-grade fever, pruritic rash on the body, and an almost 15% weight loss during the previous 3 months...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28952794/management-of-a-tibial-plafond-lung-cancer-metastasis-using-an-intramedullary-hindfoot-fusion-nail
#19
Andrew R Hsu, Adam D Lindsay
Metastatic disease to the tibial plafond is rare with few reports in the literature. No consensus exists regarding surgical reconstruction of large structural defects of the ankle due to these lesions, as each treatment must be tailored to the individual patient's goals and prognosis. Cancer metastases pose a unique challenge to limb salvage as there is often bone loss and poor soft tissue quality combined with the need for postoperative adjuvant therapy. The goal of surgery is to obtain early weightbearing, pain relief, and a durable reconstruction that will outlive the patient...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28943899/surgical-management-of-pelvic-ewing-s-sarcoma-in-children-and-adolescents
#20
Hongbin Fan, Zheng Guo, Jun Fu, Xiangdong Li, Jing Li, Zhen Wang
The present study describes a novel surgical strategy used to treat immature pelvic Ewing's sarcoma (ES), one made possible owing to the intrinsic structure of the skeletally immature pelvis. A total of 12 children and adolescents with open triradiate cartilage received limb-salvage surgeries following a diagnosis of pelvic ES. In total, 3 patients with iliac lesions (2 lesions with extension into the sacrum) received surgical tumor excisions and allograft reconstructions. Another 8 patients with periacetabular lesions received trans-acetabular osteotomies and allograft reconstructions...
October 2017: Oncology Letters
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