keyword
https://read.qxmd.com/read/38344954/sex-differences-in-androgen-receptor-estrogen-receptor-alpha-and-c-fos-co-expression-with-corticotropin-releasing-factor-expressing-neurons-in-restrained-adult-mice
#21
JOURNAL ARTICLE
Krystyna A Rybka, Jennifer J Lafrican, Zachary J Rosinger, Deborah O Ariyibi, Mecca R Brooks, Jason S Jacobskind, Damian G Zuloaga
Gonadal hormone actions through androgen receptor (AR) and estrogen receptor alpha (ERα) regulate sex differences in hypothalamic-pituitary-adrenal (HPA) axis responsivity and stress-related behaviors. Here we tested whether corticotropin releasing factor (CRF) expressing neurons, which are widely known to regulate neuroendocrine and behavioral stress responses, co-express AR and ERα as a potential mechanism for gonadal hormone regulation of these responses. Using Crh-IRES-Cre::Ai9 reporter mice we report high co-localization of AR in CRF neurons within the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BST), medial amygdala (MeA), and ventromedial hypothalamus (VMH), moderate levels within the central amygdala (CeA) and low levels in the paraventricular hypothalamus (PVN)...
November 2023: Hormones and Behavior
https://read.qxmd.com/read/38341198/immunoassay-interferences-laboratory-pitfall-in-the-diagnosis-of-adrenocortical-carcinoma
#22
JOURNAL ARTICLE
Mafalda Martins Ferreira, Carolina Moreno, Patrícia Oliveira, Isabel Paiva
A woman in her late 50s with recent onset of hypertension, diabetes, lumbar pain and unintentional weight loss was diagnosed with a cortisol and androgen-producing adrenal mass. Despite this, serum adrenocorticotropic hormone (ACTH) concentration was inappropriately elevated, which was investigated thoroughly. Investigations included a brain magnetic resonance imaging to exclude concomitant pituitary adenoma, a corticotropin-releasing hormone stimulation test and a gallium- 68 DOTATATE and 18F-FDOPA PET scan, both excluding ectopic ACTH production...
February 10, 2024: BMJ Case Reports
https://read.qxmd.com/read/38341156/larger-hypothalamic-subfield-volumes-in-patients-with-chronic-insomnia-disorder-and-relationships-to-levels-of-corticotropin-releasing-hormone
#23
JOURNAL ARTICLE
Yucai Luo, Liyong Yu, Pan Zhang, Wenting Lin, Hao Xu, Zeyang Dou, Guangli Zhao, Wei Peng, Fang Zeng, Siyi Yu
The hypothalamus is a well-established core structure in the sleep-wake cycle. While previous studies have not consistently found whole hypothalamus volume changes in chronic insomnia disorder (CID), differences may exist at the smaller substructural level of the hypothalamic nuclei. The study aimed to investigate the differences in total and subfield hypothalamic volumes, between CID patients and healthy controls (HCs) in vivo, through an advanced deep learning-based automated segmentation tool. A total of 150 patients with CID and 155 demographically matched HCs underwent T1-weighted structural magnetic resonance scanning...
February 8, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38339042/the-lack-of-trpa1-ion-channel-does-not-affect-the-chronic-stress-induced-activation-of-the-locus-ceruleus
#24
JOURNAL ARTICLE
Milica Milicic, Balázs Gaszner, Gergely Berta, Erika Pintér, Viktória Kormos
We have previously proven the involvement of transient receptor potential ankyrin 1 (TRPA1) in stress adaptation. A lack of TRPA1 affects both urocortin 1 (member of the corticotropin-releasing hormone (CRH) family) content of the Edinger-Westphal nucleus. The noradrenergic locus ceruleus (LC) is also an important player in mood control. We aimed at investigating whether the TRPA1 is expressed in the LC, and to test if the response to chronic variable mild stress (CVMS) is affected by a lack of TRPA1. The TRPA1 expression was examined via RNAscope in situ hybridization...
February 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38330420/hypothalamic-pituitary-adrenal-axis-and-epilepsy
#25
REVIEW
Xueying Bian, Wenxian Yang, Jiannan Lin, Biao Jiang, Xiaoli Shao
Epilepsy is a recurrent, transient seizure disorder of the nervous system that affects the intellectual development, life and work, and psychological health of patients. People with epilepsy worldwide experience great suffering. Stressful stimuli such as infection, mental stress, and sleep deprivation are important triggers of epilepsy, and chronic stressful stimuli can lead to frequent seizures and comorbidities. The hypothalamic-pituitary-adrenal (HPA) axis is the most important system involved in the body's stress response, and dysfunction thereof is thought to be associated with core epilepsy symptoms and related psychopathology...
February 5, 2024: Journal of Clinical Neurology
https://read.qxmd.com/read/38328253/resilience-to-early-life-adversity-effects-on-stress-reactivity-by-postnatal-knockdown-of-5-ht-1a-autoreceptors
#26
Rushell Dixon, Lauren Malave, Rory Thompson, Serena Wu, Noah Sadik, Christoph Anacker
Early Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that can protect from long-lasting effects of ELA are poorly understood. Serotonin 1A (5HT 1A ) autoreceptors in the raphé nuclei regulate adult stress vulnerability, but if 5HT 1A could be targeted to prevent ELA effects on susceptibility to future stressors is unknown. Here, we exposed mice with postnatal knockdown of 5HT 1A autoreceptors to the limited bedding and nesting model of ELA from postnatal day (P)3-10...
January 22, 2024: bioRxiv
https://read.qxmd.com/read/38326407/a-pan-cancer-analysis-uncovering-the-function-of-crhbp-in-tumor-immunity-prognosis-and-drug-response-especially-its-function-in-lihc
#27
JOURNAL ARTICLE
Bangjie Chen, Sanwei Chen, Xinyi Wang, Jianlin Zhang, Hanying Wang, Jiajin Li, Ziyu Zhang, Feng Yu, Weihao Kong
Corticotropin-releasing hormone-binding protein (CRHBP) is involved in many physiological processes. However, it is still unclear what role CRHBP has in tumor immunity and prognosis prediction. Using databases such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Tumor Protein Database, Timer Database, and Gene Expression Profiling Interactive Analysis (GEPIA), we evaluated the potential role of CRHBP in diverse cancers. Further research looked into the relationships between CRHBP and tumor survival prognosis, immune infiltration, immune checkpoint (ICP) indicators, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), DNA methylation, tumor microenvironment (TME), and drug responsiveness...
February 7, 2024: Scientific Reports
https://read.qxmd.com/read/38301651/small-molecule-cbp-p300-histone-acetyltransferase-inhibition-mobilizes-leukocytes-from-the-bone-marrow-via-the-endocrine-stress-response
#28
JOURNAL ARTICLE
Nikolai P Jaschke, Dorit Breining, Maura Hofmann, Sophie Pählig, Ulrike Baschant, Reinhard Oertel, Sofia Traikov, Tatyana Grinenko, Francesco Saettini, Andrea Biondi, Myrto Stylianou, Henrik Bringmann, Cuiling Zhang, Tomomi M Yoshida, Heike Weidner, Wolfram C Poller, Filip K Swirski, Andy Göbel, Lorenz C Hofbauer, Martina Rauner, Christoph Scheiermann, Andrew Wang, Tilman D Rachner
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive of a checkpoint of leukocyte compartment sizes. Here, we examined the impact of reversible inhibition of this domain by the small-molecule A485. We found that A485 triggered acute and transient mobilization of leukocytes from the bone marrow into the blood. Leukocyte mobilization by A485 was equally potent as, but mechanistically distinct from, granulocyte colony-stimulating factor (G-CSF), which allowed for additive neutrophil mobilization when both compounds were combined...
January 22, 2024: Immunity
https://read.qxmd.com/read/38289190/neuropeptide-expression-and-action-in-the-reproductive-system-of-the-starfish-asterias-rubens
#29
JOURNAL ARTICLE
Victor M Piñon Gonzalez, Yuling Feng, Michaela Egertová, Maurice R Elphick
Reproductive processes are regulated by a variety of neuropeptides in vertebrates and invertebrates. In starfish (phylum Echinodermata), relaxin-like gonad-stimulating peptide triggers oocyte maturation and spawning. However, little is known about other neuropeptides as potential regulators of reproduction in starfish. To address this issue, here, we used histology and immunohistochemistry to analyze the reproductive system of the starfish Asterias rubens at four stages of the seasonal reproductive cycle in male and female animals, investigating the expression of eight neuropeptides: the corticotropin-releasing hormone-type neuropeptide ArCRH, the calcitonin-type neuropeptide ArCT, the pedal peptide-type neuropeptides ArPPLN1b and ArPPLN2h, the vasopressin/ocytocin-type neuropeptide asterotocin, the gonadotropin-releasing hormone-type neuropeptide ArGnRH, and the somatostatin/allatostatin-C-type neuropeptides ArSS1 and ArSS2...
January 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38283729/remission-of-ectopic-cushing-syndrome-secondary-to-medullary-thyroid-cancer-with-vandetanib-and-selpercatinib
#30
Aria Jazdarehee, Omar Abdel-Rahman, Jennifer E Jacquier
Medullary thyroid cancer (MTC) is a neuroendocrine tumor associated with activating mutations of the rearranged during transfection ( RET ) proto-oncogene. These tumors may rarely secrete adrenocorticotropin or corticotropin-releasing hormone, resulting in a paraneoplastic ectopic Cushing syndrome (ECS). Paraneoplastic ECS carries a high risk of mortality, and management is difficult due to the lack of response to antiadrenal therapies. We report on a 37-year-old man who was diagnosed with metastatic MTC and reported symptoms of cortisol excess with laboratory testing in keeping with ECS...
February 2024: JCEM Case Rep
https://read.qxmd.com/read/38277891/floor-eggs-in-goose-breeders-patterns-genetic-and-environmental-influences-and-physiological-indexes
#31
JOURNAL ARTICLE
Wang Gu, Rongxin Chang, Qi Xu, Wenming Zhao, Guohong Chen
A floor egg is an egg that is not laid in the nest, which is a prevalent issue in many fowl breeder farms, lowering egg collection efficiency, hatching performance, and economic benefits. Although the pattern and influencing factors of floor laying have been extensively reported in chickens and ducks, it is not clear in geese. Herein, the Yangzhou goose breeders were selected, and the time and location preferences, genetic and environmental influences, and physiological indexes in floor laying were investigated...
January 17, 2024: Poultry Science
https://read.qxmd.com/read/38277725/psychological-stress-induces-hair-regenerative-disorders-through-corticotropin-releasing-hormone-mediated-autophagy-inhibition
#32
JOURNAL ARTICLE
Wenzi Liang, Yinglin Zhao, Bozhi Cai, Yuxin Huang, Xiuwen Chen, Na Ni, Yingshan Wang, Zhaoping Lin, Changmin Lin, Keng Huang
Psychosocial stress is increasing, causing a growing number of people to suffer from hair loss. Stress-related corticotropin-releasing hormone (CRH) is associated with hair loss, but the mechanism by which hair follicles respond to stress and CRH remain poorly understood. The aim of the study is to elucidate the association between CRH and stress-related hair regenerative disorders, and reveal the potential pathological mechanisms. A chronic unpredictable stress mouse model and a chronic social defeat stress mouse model were used to examine the role of CRH and stress-related hair regrowth...
January 23, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38248278/chronic-nicotine-consumption-and-withdrawal-regulate-melanocortin-receptor-crf-and-crf-receptor-mrna-levels-in-the-rat-brain
#33
JOURNAL ARTICLE
Oguz Gozen, Buket Aypar, Meliha Ozturk Bintepe, Fulya Tuzcu, Burcu Balkan, Ersin O Koylu, Lutfiye Kanit, Aysegul Keser
Alterations in the various neuropeptide systems in the mesocorticolimbic circuitry have been implicated in negative effects associated with drug withdrawal. The corticotropin-releasing factor (CRF) and α-melanocyte-stimulating hormone are two peptides that may be involved. This study investigated the regulatory effects of chronic nicotine exposure and withdrawal on the mRNA levels of melanocortin receptors (MC3R, MC4R), CRF, and CRF receptors (CRFR1 and CRFR2) expressed in the mesocorticolimbic system...
January 9, 2024: Brain Sciences
https://read.qxmd.com/read/38241961/early-life-adversity-accelerates-hypothalamic-drive-of-pubertal-timing-in-female-rats-with-associated-enhanced-acoustic-startle
#34
JOURNAL ARTICLE
Lauren Granata, Michaela Fanikos, Heather C Brenhouse
Early life adversity in the form of childhood maltreatment in humans or as modeled by maternal separation (MS) in rodents is often associated with an earlier emergence of puberty in females. Earlier pubertal initiation is an example of accelerated biological aging and predicts later risk for anxiety in women, especially in populations exposed to early life trauma. Here we investigated external pubertal markers as well as hypothalamic gene expression of pubertal regulators kisspeptin and gonadotropin-releasing hormone, to determine a biological substrate for MS-induced accelerated puberty...
January 18, 2024: Hormones and Behavior
https://read.qxmd.com/read/38241377/corticotropin-releasing-hormone-neurons-control-trigeminal-neuralgia-induced-anxiodepression-via-a-hippocampus-to-prefrontal-circuit
#35
JOURNAL ARTICLE
Su-Su Lv, Xue-Jing Lv, Ya-Qi Cai, Xin-Yu Hou, Zhi-Zhe Zhang, Guo-Hong Wang, Li-Qiang Chen, Ning Lv, Yu-Qiu Zhang
Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits and mechanisms underlying this association are poorly understood. Here, we identified a dedicated neural circuit from the ventral hippocampus (vHPC) to the medial prefrontal cortex (mPFC) that mediates TN-related anxiodepression. We found that TN caused an increase in excitatory synaptic transmission from vHPCCaMK2A neurons to mPFC inhibitory neurons marked by the expression of corticotropin-releasing hormone (CRH)...
January 19, 2024: Science Advances
https://read.qxmd.com/read/38239406/the-expression-and-possible-role-of-corticotropin-releasing-hormone-family-peptides-and-their-corresponding-receptors-in-gynaecological-malignancies-and-premalignant-conditions-a-systematic-review
#36
REVIEW
Angelos Dimas, Chrysoula Margioula-Siarkou, Anastasia Politi, Alexandros Sotiriadis, Alexios Papanikolaou, Konstantinos Dinas, Stamatios Petousis
The aim of this systematic review is to investigate the impact of corticotropin-releasing hormone (CRH) family peptides and their corresponding receptors on human physiology and disease onset, with a specific focus on gynaecological malignancies such as breast, endometrial, ovarian, vulvar, and cervical cancer. A comprehensive systematic review of 3 medical databases was conducted by 2 independent reviewers. We reviewed studies that explored the expression and role of CRH peptides in various aspects of cancer biology, in the context of breast, endometrial, ovarian, vulvar, and cervical cancer...
December 2023: Menopause Review
https://read.qxmd.com/read/38232531/early-life-adversity-in-primates-behavioral-endocrine-and-neural-effects
#37
JOURNAL ARTICLE
Do P M Tromp, Andrew S Fox, Marissa K Riedel, Jonathan A Oler, Xiaojue Zhou, Patrick H Roseboom, Andrew L Alexander, Ned H Kalin
BACKGROUND: Evidence suggests that early life adversity is associated with maladaptive behaviors and is commonly an antecedent of stress-related psychopathology. This is particularly relevant to rearing in primate species as infant primates depend on prolonged, nurturant rearing by caregivers for normal development. To further understand the consequences of early life rearing adversity, and the relation among alterations in behavior, physiology and brain function, we assessed young monkeys that had experienced maternal separation followed by peer rearing with behavioral, endocrine and multimodal neuroimaging measures...
January 6, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38227343/metabolic-and-behavioral-alterations-associated-with-viral-vector-mediated-toxicity-in-the-paraventricular-hypothalamic-nucleus
#38
JOURNAL ARTICLE
Rohan Savani, Erin Park, Nidhi Busannagari, Yi Lu, Hyokjoon Kwon, Le Wang, Zhiping P Pang
OBJECTIVE: Combining adeno-associated virus (AAV)-mediated expression of Cre recombinase with genetically modified floxed animals is a powerful approach for assaying the functional role of genes in regulating behavior and metabolism. Extensive research in diverse cell types and tissues using AAV-Cre has shown it can save time and avoid developmental compensation as compared to using Cre driver mouse line crossings. We initially sought to study the impact of ablation of corticotropin-releasing hormone (CRH) in the paraventricular hypothalamic nucleus (PVN) using intracranial AAV-Cre injection in adult animals...
January 16, 2024: Bioscience Reports
https://read.qxmd.com/read/38199409/blood-mrna-expression-levels-of-glucocorticoid-receptors-and-fkbp5-are-associated-with-depressive-disorder-and-altered-hpa-axis
#39
JOURNAL ARTICLE
Hiroaki Hori, Fuyuko Yoshida, Ikki Ishida, Junko Matsuo, Shintaro Ogawa, Kotaro Hattori, Yoshiharu Kim, Hiroshi Kunugi
BACKGROUND: While depression has been associated with alterations in the hypothalamic-pituitary adrenal (HPA) axis function, there is still controversy regarding the nature and extent of the dysfunction, such as in the debate about hypercortisolism vs. hypocortisolism. It may therefore be necessary to understand whether and how HPA axis function in depression is linked to mRNA expression of key genes regulating this system. METHODS: We studied 163 depressed outpatients, most of whom were chronically ill, and 181 healthy controls...
January 9, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38191479/optogenetic-recruitment-of-hypothalamic-corticotrophin-releasing-hormone-crh-neurons-reduces-motivational-drive
#40
JOURNAL ARTICLE
Caitlin S Mitchell, Erin J Campbell, Simon D Fisher, Laura M Stanton, Nicholas J Burton, Amy J Pearl, Gavan P McNally, Jaideep S Bains, Tamás Füzesi, Brett A Graham, Elizabeth E Manning, Christopher V Dayas
Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational drive, the mechanisms underpinning this association remain unclear. One hypothesis is that the endocrine system, via corticotropin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN; PVNCRH ), initiates a hormonal cascade resulting in glucocorticoid release, and that excessive glucocorticoids change brain circuit function to produce depression-related symptoms...
January 8, 2024: Translational Psychiatry
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