Nikolai P Jaschke, Dorit Breining, Maura Hofmann, Sophie Pählig, Ulrike Baschant, Reinhard Oertel, Sofia Traikov, Tatyana Grinenko, Francesco Saettini, Andrea Biondi, Myrto Stylianou, Henrik Bringmann, Cuiling Zhang, Tomomi M Yoshida, Heike Weidner, Wolfram C Poller, Filip K Swirski, Andy Göbel, Lorenz C Hofbauer, Martina Rauner, Christoph Scheiermann, Andrew Wang, Tilman D Rachner
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive of a checkpoint of leukocyte compartment sizes. Here, we examined the impact of reversible inhibition of this domain by the small-molecule A485. We found that A485 triggered acute and transient mobilization of leukocytes from the bone marrow into the blood. Leukocyte mobilization by A485 was equally potent as, but mechanistically distinct from, granulocyte colony-stimulating factor (G-CSF), which allowed for additive neutrophil mobilization when both compounds were combined...
January 22, 2024: Immunity