keyword
MENU ▼
Read by QxMD icon Read
search

Corticotropin releasing hormone

keyword
https://www.readbyqxmd.com/read/29338944/histological-and-morphofunctional-parameters-of-the-hypothalamic-pituitary-adrenal-system-are-sensitive-to-daidzein-treatment-in-the-adult-rat
#1
Svetlana Trifunović, Milica Manojlović-Stojanoski, Nataša Nestorović, Nataša Ristić, Branka Šošić-Jurjević, Lazo Pendovski, Verica Milošević
The isoflavone, daidzein is a biologically active, plant-derived compound that interacts with estrogen receptors. Data from previous studies have suggested that daidzein exerts beneficial effects in many diseases; however, as an endocrine disrupter, it may also alter the functioning of the endocrine system. Data regarding the effect of daidzein on the morphofunctional and histological parameters of the hypothalamic-pituitary-adrenal (HPA) system is still lacking. Therefore, using the newCAST stereological software, we investigated the effects of chronic (21 days) daidzein treatment on corticotropin-releasing hormone (CRH) neurons within the hypothalamus and corticotropes (ACTH cells) in the pituitary, while image analysis was employed to-examine the intensity of fluorescence of CRH in the median eminence (ME) and adrenocorticotropin hormone in the pituitary in adult orchidectomized (Ovx) rats...
January 12, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29317694/murine-splenic-b-cells-express-corticotropin-releasing-hormone-receptor-2-that-affect-their-viability-during-a-stress-response
#2
Guillaume Harlé, Sandra Kaminski, David Dubayle, Jean-Pol Frippiat, Armelle Ropars
Chronic stress is now recognized as a risk factor for disease development and/or exacerbation. It has been shown to affect negatively the immune system and notably the humoral immune response. Corticotropin-releasing hormone (CRH) is known to play a crucial role in stress response. CRH receptors are expressed on different immune cells such as granulocytes, monocytes and T cells. However, up to now, no CRH receptor has been described on B cells which are key players of the humoral immune response. In order to highlight new pathways by which stress may impact immunity, we investigated the role of CRH in B cells...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315139/-dtpa-pabn-leu5-des-acyl-ghrelin-1-5-as-a-new-carrier-of-radionuclides-and-potential-precursor-of-radiopharmaceuticals
#3
Grzegorz Wójciuk, Marcin Kruszewski
BACKGROUND: Ghrelin is a peptide consisting of 28 aminoacids and an octadecyl side chain (acyl group) binding to the growth hormone secretagogue receptor type 1a (GHS-R1a). Its des-acylated form, des-acyl ghrelin (DAG) binds to the corticotropin releasing factor receptor type 2a (CRF2a) located on endocrine cancer cells such as the prostate carcinoma cell line DU 145. AIM: The aim of this study is to develop a new DAG-based carrier of radionuclides with potential application in therapy...
January 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29311741/social-transmission-and-buffering-of-synaptic-changes-after-stress
#4
Toni-Lee Sterley, Dinara Baimoukhametova, Tamás Füzesi, Agnieszka A Zurek, Nuria Daviu, Neilen P Rasiah, David Rosenegger, Jaideep S Bains
Stress can trigger enduring changes in neural circuits and synapses. The behavioral and hormonal consequences of stress can also be transmitted to others, but whether this transmitted stress has similar effects on synapses is not known. We found that authentic stress and transmitted stress in mice primed paraventricular nucleus of the hypothalamus (PVN) corticotropin-releasing hormone (CRH) neurons, enabling the induction of metaplasticity at glutamate synapses. In female mice that were subjected to authentic stress, this metaplasticity was diminished following interactions with a naive partner...
January 8, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29306937/the-effects-of-stress-and-meditation-on-the-immune-system-human-microbiota-and-epigenetics
#5
Ayman Mukerji Househam, Christine Tara Peterson, Deepak Chopra
Context • Globally, more than 25% of individuals are affected by anxiety and depression disorders. Meditation is gaining popularity in clinical settings and its treatment efficacy is being studied for a wide array of psychological and physiological ailments. An exploration of stress physiology is an essential precursor to delineation of the mechanisms underlying the beneficial effects of meditation practices. Objective • The review outlines a model of interconnected physiological processes that might support the continued inclusion and expansion of meditation in the treatment of diverse medical conditions and to investigate the role that gut microbiota may play in realizing well-being through meditation...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29305536/pou6f1-mediates-neuropeptide-dependent-plasticity-in-the-adult-brain
#6
Cynthia K McClard, Mikhail Y Kochukov, Isabella Herman, Zhandong Liu, Aiden Eblimit, Yalda Moayedi, Joshua Ortiz-Guzman, Daniel Colchado, Brandon Pekarek, Sugi Paneerselvam, Graeme Mardon, Benjamin R Arenkiel
The mouse olfactory bulb (OB) features continued, activity-dependent integration of adult-born neurons, providing a robust model to examine mechanisms of plasticity in the adult brain. We previously reported that local OB interneurons secrete the neuropeptide corticotropin releasing hormone (CRH) in an activity-dependent manner onto adult-born granule neurons, and that local CRH signaling promotes expression of synaptic machinery in the bulb. This effect is mediated via activation of the CRH receptor 1 (CRHR1), which is developmentally regulated during adult-born neuron maturation...
January 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29277323/epigenetic-changes-in-the-crh-gene-are-related-to-severity-of-suicide-attempt-and-a-general-psychiatric-risk-score-in-adolescents
#7
Jussi Jokinen, Adrian E Boström, Ali Dadfar, Diana M Ciuculete, Andreas Chatzittofis, Marie Åsberg, Helgi B Schiöth
The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was measured in whole blood using the Illumina Infinium Methylation EPIC BeadChip. Subjects were stratified into high-risk and low-risk groups based on the severity of the suicidal behavior...
December 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29275218/myrcia-sylvatica-essential-oil-mitigates-molecular-biochemical-and-physiological-alterations-in-rhamdia-quelen-under-different-stress-events-associated-to-transport
#8
Etiane M H Saccol, Ismael Jerez-Cepa, Giovana M Ourique, Tanise S Pês, Luciane T Gressler, Rosa H V Mourão, Gonzalo Martínez-Rodríguez, Juan M Mancera, Bernardo Baldisserotto, Maria A Pavanato, Juan A Martos-Sitcha
The effects of pre-transport handling and addition of essential oil of Myrcia sylvatica (EOMS) during transport on stress pathways activation in Rhamdia quelen were investigated. Fish (n=400, 25.2±2.9g) were captured in production ponds and transferred to 100-L tank (density 100g L-1). After 24h, 10 fish were sampled (before transport group). The remaining fish were placed in plastic bags (n=30 or 32 fish per bag, density 150g L-1) containing 5L of water (control), ethanol (315μLL-1, vehicle) or EOMS (25 or 35μLL-1), in triplicate, transported for 6h and sampled (n=10 animals per group)...
December 15, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29251255/effects-of-genetic-factors-to-inhaled-corticosteroid-response-in-children-with-asthma-a-literature-review
#9
Huong Duong-Thi-Ly, Ha Nguyen-Thi-Thu, Long Nguyen-Hoang, Hanh Nguyen-Thi-Bich, Timothy J Craig, Sy Duong-Quy
Numerous studies have examined the association between pharmacogenetic effects and the response to inhaled corticosteroids (ICS) in patients with asthma. In fact, several single nucleotide polymorphisms of a number of candidate genes have been identified that might influence the clinical response to ICS in children with asthma. Their direct or indirect effects depend on their role in the inflammatory process in asthma or the anti-inflammatory action of corticosteroids, respectively. Among the genes identified, variants in T-box 21 ( TBX21) and Fc fragment of IgE receptor II ( FCER2) contribute indirectly to the variability in the response to ICS by altering the inflammatory mechanisms in asthma, while other genes such as corticotropin releasing hormone receptor 1 ( CRHR1), nuclear receptor subfamily 3 group C member 1 ( NR3C1), stress induced phosphoprotein 1 ( STIP1), dual specificity phosphatase 1 (DUSP1), glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory mechanisms of ICS...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29241359/antidepressant-outcomes-predicted-by-genetic-variation-in-corticotropin-releasing-hormone-binding-protein
#10
Chloe P O'Connell, Andrea N Goldstein-Piekarski, Charles B Nemeroff, Alan F Schatzberg, Charles Debattista, Tania Carrillo-Roa, Elisabeth B Binder, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Leanne M Williams
OBJECTIVE: Genetic variation within the hypothalamic-pituitary-adrenal (HPA) axis has been linked to risk for depression and antidepressant response. However, these associations have yet to produce clinical gains that inform treatment decisions. The authors investigated whether variation within HPA axis genes predicts antidepressant outcomes within two large clinical trials. METHOD: The test sample comprised 636 patients from the International Study to Predict Optimized Treatment in Depression (iSPOT-D) who completed baseline and 8-week follow-up visits and for whom complete genotyping data were available...
December 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29230947/dietary-slowly-digestible-starch-triggers-the-gut-brain-axis-in-obese-rats-with-accompanied-reduced-food-intake
#11
Like Y Hasek, Robert J Phillips, Genyi Zhang, Kimberly P Kinzig, Choon Young Kim, Terry L Powley, Bruce R Hamaker
SCOPE: Slowly digestible starch (SDS), as a functional carbohydrate providing a slow and sustained glucose release, may be able to modulate food intake through activation of the gut-brain axis. METHODS AND RESULTS: Diet-induced obese rats were used to test the effect on feeding behavior of high fat (HF) diets containing a SDS, fabricated to digest into the ileum, as compared to rapidly digestible starch (RDS). Ingestion of the HF-SDS diet over an 11-week period reduced daily food intake, through smaller meal size, to the same level as a lean body control group, while the group consuming the HF-RDS diet remained at a high food intake...
December 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29186699/seizure-induced-activation-of-the-hpa-axis-increases-seizure-frequency-and-comorbid-depression-like-behaviors
#12
Andrew Hooper, Rumzah Paracha, Jamie Maguire
Our laboratory recently demonstrated that seizures activate the hypothalamic-pituitary-adrenal (HPA) axis, increasing circulating levels of corticosterone (O'Toole et al., 2013). Given the well-established proconvulsant actions of corticosterone, we hypothesized that seizure-induced activation of the HPA axis may contribute to future seizure susceptibility. Further, since hypercortisolism is associated with depression, we propose that seizure-induced activation of the HPA axis may contribute to comorbid depression and epilepsy...
November 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29183827/complex-environmental-rearing-enhances-social-salience-and-affects-hippocampal-corticotropin-releasing-hormone-receptor-crhr-1-crhr2-expression-in-a-sex-specific-manner
#13
Amanda C Kentner, Erika Lima, Mattia M Migliore, Junyoung Shin, Stephanie Scalia
Methods for understanding the neurocircuitry of ethologically relevant behaviors have advanced substantially; however renovations to standard animal laboratory housing, in the form of enhanced enrichment, have lagged behind. This is despite evidence that environmental enrichment (EE) reduces stress, stereotypy, and promotes healthy species typical behaviors. While many scientists express interest for increased EE as a standard for animal caging systems, there are concerns that its effects on brain, behavior, and cognition are not well characterized...
November 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/29180955/dissociable-role-of-corticotropin-releasing-hormone-receptor-subtype-1-on-dopaminergic-and-d1-dopaminoceptive-neurons-in-cocaine-seeking-behavior
#14
Rick E Bernardi, Laura Broccoli, Natalie Hirth, Nicholas J Justice, Jan M Deussing, Anita C Hansson, Rainer Spanagel
The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system, in which CRH exerts its effects partly via the CRH receptor subtype 1 (CRHR1) in extra-hypothalamic areas. In fact, CRHR1 expressed in regions of the mesolimbic dopamine (DA) system have been demonstrated to modify cocaine-induced DA release and alter cocaine-mediated behaviors. Here we examined the role of neuronal selectivity of CRHR1 within the mesolimbic system on cocaine-induced behaviors...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29158579/rare-susceptibility-variants-for-bipolar-disorder-suggest-a-role-for-g-protein-coupled-receptors
#15
C Cruceanu, J-F Schmouth, S G Torres-Platas, J P Lopez, A Ambalavanan, E Darcq, F Gross, B Breton, D Spiegelman, D Rochefort, P Hince, J M Petite, J Gauthier, R G Lafrenière, P A Dion, C M Greenwood, B L Kieffer, M Alda, G Turecki, G A Rouleau
Bipolar disorder (BD) is a prevalent mood disorder that tends to cluster in families. Despite high heritability estimates, few genetic susceptibility factors have been identified over decades of genetic research. One possible interpretation for the shortcomings of previous studies to detect causative genes is that BD is caused by highly penetrant rare variants in many genes. We explored this hypothesis by sequencing the exomes of affected individuals from 40 well-characterized multiplex families. We identified rare variants segregating with affected status in many interesting genes, and found an enrichment of deleterious variants in G protein-coupled receptor (GPCR) family genes, which are important drug targets...
November 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#16
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29146410/cart-neurons-in-the-arcuate-nucleus-and-lateral-hypothalamic-area-exert-differential-controls-on-energy-homeostasis
#17
Jackie Lau, Aitak Farzi, Yue Qi, Regine Heilbronn, Mario Mietzsch, Yan-Chuan Shi, Herbert Herzog
OBJECTIVE: The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been reported. METHODS: By combining Cart-cre knock-in mice with a Cart adeno-associated viral vector designed using the flip-excision switch (AAV-FLEX) technology, specific reintroduction or overexpression of CART selectively in CART neurons in the arcuate nucleus (Arc) and lateral hypothalamic area (LHA), respectively, was achieved...
November 8, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29137551/environmental-manipulations-as-an-effective-alternative-treatment-to-reduce-endometriosis-progression
#18
Annelyn Torres-Reverón, Leslie L Rivera, Idhaliz Flores, Caroline B Appleyard
Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplantation rat model. Female rats were exposed to EE (endo-EE: toys and nesting materials, 4 rats per cage, larger area enclosure) or no enrichment (endo-NE: 2 rats per cage) starting on postnatal day 21. After 8 weeks, sham surgery or surgical endometriosis was induced by suturing uterine horn tissue next to the intestinal mesentery, then allowed to progress for 60 days during which EE or NE continued...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29137071/a-comparative-study-of-biological-and-metabolic-biomarkers-between-healthy-individuals-and-patients-with-acne-vulgaris-a-cross-sectional-study-protocol
#19
COMPARATIVE STUDY
Kyuseok Kim, Injin Ha, Eunok Kim, Kyunglee Kim
Acne is a multifactorial dermatosis, which is influenced not only by hormones but also by the biochemical relationship between them and the pilosebaceous unit. Inflammatory cytokines, chemokines, active oxygen, and zinc are known to be associated with the development of acne. Further, steroid metabolism is known as one of the important factors related to sebum secretion and comedone formation in acne. However, there is a lack of studies comparing these human biomarkers between healthy individuals and patients with acne...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134359/anxiety-depression-and-the-microbiome-a-role-for-gut-peptides
#20
REVIEW
Gilliard Lach, Harriet Schellekens, Timothy G Dinan, John F Cryan
The complex bidirectional communication between the gut and the brain is finely orchestrated by different systems, including the endocrine, immune, autonomic, and enteric nervous systems. Moreover, increasing evidence supports the role of the microbiome and microbiota-derived molecules in regulating such interactions; however, the mechanisms underpinning such effects are only beginning to be resolved. Microbiota-gut peptide interactions are poised to be of great significance in the regulation of gut-brain signaling...
November 13, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
keyword
keyword
76564
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"