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https://www.readbyqxmd.com/read/29327257/biomechanical-characterisation-of-bone-anchored-implant-systems-for-amputation-limb-prostheses-a-systematic-review
#1
REVIEW
Alexander Thesleff, Rickard Brånemark, Bo Håkansson, Max Ortiz-Catalan
Bone-anchored limb prostheses allow for the direct transfer of external loads from the prosthesis to the skeleton, eliminating the need for a socket and the associated problems of poor fit, discomfort, and limited range of movement. A percutaneous implant system for direct skeletal attachment of an external limb must provide a long-term, mechanically stable interface to the bone, along with an infection barrier to the external environment. In addition, the mechanical integrity of the implant system and bone must be preserved despite constant stresses induced by the limb prosthesis...
January 11, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29319405/does-stroke-rehabilitation-really-matter-part-a-proportional-stroke-recovery-in-the-rat
#2
Matthew Strider Jeffers, Sudhir Karthikeyan, Dale Corbett
BACKGROUND: In human upper-limb stroke, initial level of functional impairment or corticospinal tract injury can accurately predict the degree of poststroke recovery, independent of rehabilitation practices. This proportional recovery rule implies that current rehabilitation practices may play little or no role in brain repair, with recovery largely a result of spontaneous biological recovery processes. OBJECTIVE: The present study sought to determine if similar biomarkers predict recovery of poststroke function in rats, indicating that an endogenous biological recovery process might be preserved across mammalian species...
January 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29309334/retrospective-review-of-free-anterolateral-thigh-flaps-for-limb-salvage-in-severely-injured-high-voltage-electrical-burn-patients
#3
Jing-Chun Zhao, Kai Shi, Lei Hong, Zheng-Hua Jin, Xi Zhang, Xin-Xin Gao, Jia-Ao Yu
BACKGROUND: High-voltage electrical injuries usually cause extensive and devastating damages to the extremities. Timely and effective coverage of the wounds to maximally preserve the viable tissue is important for salvage and the ultimate functional outcome of the involved extremities. In this study, free anterolateral thigh flaps with a single-perforator pedicle were conducted to maximize tissue salvage and decrease late skeletal and neuromuscular complications of the involved extremities injured by high-voltage electricity...
January 5, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29301545/personalized-upper-limb-training-combined-with-anodal-tdcs-for-sensorimotor-recovery-in-spastic-hemiparesis-study-protocol-for-a-randomized-controlled-trial
#4
Mindy F Levin, Melanie C Baniña, Silvi Frenkel-Toledo, Sigal Berman, Nachum Soroker, John M Solomon, Dario G Liebermann
BACKGROUND: Recovery of voluntary movement is a main rehabilitation goal. Efforts to identify effective upper limb (UL) interventions after stroke have been unsatisfactory. This study includes personalized impairment-based UL reaching training in virtual reality (VR) combined with non-invasive brain stimulation to enhance motor learning. The approach is guided by limiting reaching training to the angular zone in which active control is preserved ("active control zone") after identification of a "spasticity zone"...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29298705/motor-modules-during-adaptation-to-walking-in-a-powered-ankle-exoskeleton
#5
Daniel A Jacobs, Jeffrey R Koller, Katherine M Steele, Daniel P Ferris
BACKGROUND: Modules of muscle recruitment can be extracted from electromyography (EMG) during motions, such as walking, running, and swimming, to identify key features of muscle coordination. These features may provide insight into gait adaptation as a result of powered assistance. The aim of this study was to investigate the changes (module size, module timing and weighting patterns) of surface EMG data during assisted and unassisted walking in an powered, myoelectric, ankle-foot orthosis (ankle exoskeleton)...
January 3, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29290606/isolated-loss-of-active-external-rotation-a-distinct-entity-and-results-of-l-episcopo-tendon-transfer
#6
Pascal Boileau, Mohammed Baba, Walter B McClelland, Charles-Édouard Thélu, Christophe Trojani, Nicolas Bronsard
BACKGROUND: The purpose of this study was to characterize a subgroup of cuff-deficient patients with isolated loss of active external rotation (ILER) but preserved active elevation and to evaluate the outcomes of the L'Episcopo procedure to restore horizontal muscle balance. METHODS: During a 10-year period, 26 patients (14 men, 12 women) were identified with ILER in the setting of massive irreparable posterosuperior cuff tears. A modified L'Episcopo tendon transfer was performed to restore active external rotation and to improve shoulder function...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29285371/en-bloc-resection-intraoperative-extracorporeal-irradiation-and-re-implantation-of-involved-bone-for-the-treatment-of-limb-malignancies
#7
Shuai Zhang, Xu-Quan Wang, Jia-Jia Wang, Mei-Tao Xu
Reconstruction of the defect following limb-sparing resection of malignant bone tumors is controversial and extremely challenging. Extracorporeal irradiation (ECI) and re-implantation have been used for limb salvage surgery for patients, with major advantages, including biological reconstruction, ready availability and preservation of bone stock, over replacement with a megaprosthesis. The purpose of the present study was to present our experience and details of all patients treated with this surgery. Between June 2005 and December 2014, we followed-up 23 patients with limb malignancies who were treated with en bloc excision followed by 50-Gy single dose ECI and re-implantation of involved bone segments...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29261329/the-impact-of-stepfamily-relationship-quality-on-emerging-adult-non-medical-use-of-prescription-drugs
#8
Kaitlin P Ward, Cory B Dennis, Gordon E Limb
BACKGROUND: Emerging adults aged 18 to 25 are most at-risk for non-medical use of prescription drugs (NMUPD). While the literature dedicated to emerging-adult NMUPD has explored risk and protective factors at an individual level, much less is known regarding how interpersonal and familial factors relate to NMUPD. Because interpersonal bonds can have a significant impact on behavior, familial factors may be important predictors of NMUPD among emerging adults. OBJECTIVES: Inasmuch as growing up in a stepfamily is increasingly common for children, this study aimed to determine whether perceived stepfamily quality within three stepfamily subsystems - child-biological parent, child-stepparent, and child-stepsibling - decreased the likelihood of NMUPD in emerging adulthood...
December 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29251205/novel-endovascular-approach-using-the-gore-iliac-branch-endograft-for-short-iliac-anatomy
#9
Kejia Wang, Laura Dunkley, Michael Neale
PURPOSE: To report the use of a branched iliac endograft to maintain internal iliac artery (IIA) patency in a patient with an infrarenal aortic aneurysm and short common iliac arteries (CIA). CASE REPORT: A 74-year-old man presented with an asymptomatic, fusiform, 67-mm infrarenal aortic aneurysm confirmed on computed tomography. The right CIA was funnel shaped and only 15 mm in length, providing no appropriate stent-graft landing zone. The left CIA measured 14 mm in diameter and 25 mm in length...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29248237/the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-system-correlates-with-cost-of-care-for-diabetic-foot-ulcers-treated-in-a-multidisciplinary-setting
#10
Caitlin W Hicks, Joseph K Canner, Hikmet Karagozlu, Nestoras Mathioudakis, Ronald L Sherman, James H Black, Christopher J Abularrage
OBJECTIVE: We have previously demonstrated that the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification correlates with wound healing time in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. Our aim was to assess whether the charges and costs associated with DFU care increase with higher WIfI stages. METHODS: All patients presenting to our multidisciplinary diabetic limb preservation service from June 2012 to June 2016 were enrolled in a prospective database...
December 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#11
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29229672/detecting-differential-copy-number-variation-between-groups-of-samples
#12
Craig B Lowe, Nicelio Sanchez-Luege, Timothy R Howes, Shannon D Brady, Rhea R Richardson, Felicity C Jones, Michael A Bell, David M Kingsley
We present a method to detect copy number variants (CNVs) that are differentially present between two groups of sequenced samples. We use a finite-state transducer where the emitted read depth is conditioned on the mappability and GC-content of all reads that occur at a given base position. In this model, the read depth within a region is a mixture of binomials, which in simulations matches the read depth more closely than the often-used negative binomial distribution. The method analyzes all samples simultaneously, preserving uncertainty as to the breakpoints and magnitude of CNVs present in an individual when it identifies CNVs differentially present between the two groups...
December 11, 2017: Genome Research
https://www.readbyqxmd.com/read/29226200/long-term-results-of-osteoarticular-allograft-reconstruction-in-children-with-distal-femoral-bone-tumors
#13
Khodamorad Jamshidi, Mehrdad Bahrabadi, Alireza Mirzaei
Background: There is no consensus regarding the best method of reconstruction in pediatric population following the wide resection of malignant bone tumors. More exploration of the complications of osteoarticular reconstruction leads to less existing controversy of this type of reconstruction, which is the main point of this article. Methods: Long-term outcomes and complications of osteoarticular allograft reconstruction of primary distal femoral bone sarcomas in 22 children with mean age of 10...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29221684/ex-vivo-flush-of-the-limb-allograft-reduces-inflammatory-burden-prior-to-transplantation
#14
Kavit R Amin, Alexandra L Ball, Chandanpreet Chhina, Rebecca J Edge, John P Stone, William R Critchley, Jason K Wong, James E Fildes
BACKGROUND: Passenger leucocytes and inflammatory debris transferred from the donor limb to the recipient can induce allorecognition, which activates the host immune response. This is the first study to evaluate whether the transfer of this inflammatory burden can be reduced via post-preservation flush prior to revascularisation, and whether this is influenced by ischaemia. METHODS: Bilateral forelimbs from the same pig were procured and infused with preservation flush and stored on ice...
November 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29219183/mechanical-unloading-reduces-microtubule-actin-crosslinking-factor-1-expression-to-inhibit-%C3%AE-catenin-signaling-and-osteoblast-proliferation
#15
Chong Yin, Yan Zhang, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang, Airong Qian, Cory J Xian
Mechanical unloading was considered a major threat to bone homeostasis, and has been shown to decrease osteoblast proliferation although the underlying mechanism is unclear. Microtubule actin crosslinking factor 1 (MACF1) is a cytoskeletal protein that regulates cellular processes and Wnt/β-catenin pathway, an essential signaling pathway for osteoblasts. However, the relationship between MACF1 expression and mechanical unloading, and the function and the associated mechanisms of MACF1 in regulating osteoblast proliferation are unclear...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29218386/anatomical-study-of-medial-sural-artery-and-its-perforators-in-nepalese-an-aid-to-reconstructive-surgery
#16
Laju Maya Basnet, Samit Kumar Ghosh, Sunara Shrestha, Shaligram Dhungel
OBJECTIVE: The present study was undertaken to know the anatomical basis of medial sural artery (MSA) and its perforators in Nepalese. METHODS: The popliteal arteries of 16 preserved cadaveric lower limbs were injected with a mixture of red ink and glycerine. The number, location, diameter of perforators; length and intramuscular course of pedicle; the branching pattern of MSA were observed and measured. RESULTS: The mean of 2.2 ± 1.2 perforators (range 0-4) was observed...
December 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29215949/laparoscopic-retroperitoneal-lymph-node-dissection-as-a-safe-procedure-for-postchemotherapy-residual-mass-in-testicular-cancer
#17
Eliney Ferreira Faria, Hugo Silva Neves, Breno Dauster, Roberto Dias Machado, Wesley Justino Magnabosco, Roberto Lodeiro Muller, Alexandre César Santos, Marcos Tobias-Machado
BACKGROUND: To evaluate the feasibility, clinical and perioperative outcomes of laparoscopic retroperitoneal lymph node dissection (L-RPLND) in the management of patients with germ cell tumors (GCT) and residual post-chemotherapy mass. METHODS: We report our experience of 25 patients treated with L-RPLND between 2008 and 2015. All 25 patients were diagnosed with GCT by primary pathological evaluation of the specimens after orchiectomy. All patients received cisplatin-based chemotherapy...
December 7, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29210895/characteristics-of-upper-limb-pull-power-and-power-endurance-in-japanese-female-wrestlers
#18
Tatsuki Naka, Masaaki Kanno, Shota Shidochi, Kazuhito Sakae, Norihiro Shima
This study aimed at elucidating the characteristics of upper-limb physical strength required by female wrestlers by comparing the pull power, power endurance, and number of repetitions between female wrestlers at world and national levels. The subjects were 20 female wrestlers (8 Olympic- and/or world-class and 12 national-class top-ranking individuals). The subjects assumed a lying prone (face down) position on a bench and pulled a bar from arms length until contact with underside of bench. The weight load was increased in 10-kg steps and the upper-limb pull power was measured for each lift...
November 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29209188/age-related-decline-of-wrist-position-sense-and-its-relationship-to-specific-physical-training
#19
Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L Keller-Ross
Perception of limb and body positions is known as proprioception. Sensory feedback, especially from proprioceptive receptors, is essential for motor control. Aging is associated with a decline in position sense at proximal joints, but there is inconclusive evidence of distal joints being equally affected by aging. In addition, there is initial evidence that physical activity attenuates age-related decline in proprioception. Our objectives were, first, to establish wrist proprioceptive acuity in a large group of seniors and compare their perception to young adults, and second, to determine if specific types of training or regular physical activity are associated with preserved wrist proprioception...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29205361/vascular-anatomy-of-the-jejunal-mesentery-and-complications-associated-with-division-of-the-first-jejunal-venous-trunk-during-pancreaticoduodenectomy
#20
Yuta Kobayashi, Yoshihiro Sakamoto, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Little is known about the anatomy of the jejunal veins (JVs) flowing into the superior mesenteric vein (SMV), and whether they can be safely divided during pancreaticoduodenectomy. METHODS: Computed tomography was used to review the jejunal branches off the superior mesenteric artery (SMA) and into the SMV in 123 consecutive patients. The common trunk of the JVs (jejunal venous trunk, JVT) was classified as ventral or dorsal to the SMA. RESULTS: The first JVT involved multiple JVs in 108 (87...
December 4, 2017: Journal of Surgical Oncology
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