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Limb preservation

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https://www.readbyqxmd.com/read/29784780/early-fossil-record-of-euarthropoda-and-the-cambrian-explosion
#1
Allison C Daley, Jonathan B Antcliffe, Harriet B Drage, Stephen Pates
Euarthropoda is one of the best-preserved fossil animal groups and has been the most diverse animal phylum for over 500 million years. Fossil Konservat-Lagerstätten, such as Burgess Shale-type deposits (BSTs), show the evolution of the euarthropod stem lineage during the Cambrian from 518 million years ago (Ma). The stem lineage includes nonbiomineralized groups, such as Radiodonta (e.g., Anomalocaris ) that provide insight into the step-by-step construction of euarthropod morphology, including the exoskeleton, biramous limbs, segmentation, and cephalic structures...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29776846/moderators-of-angiogenesis-in-muscle-flaps-a-non-randomised-animal-study
#2
Kimberley Bradshaw, Michael Wagels
INTRODUCTION: A muscle flap can survive a pedicle injury under favourable conditions. In the reconstruction of compound limb injuries, the wound milieu is variable and may affect the rate and manner of neovascularisation. Our aim is to determine the effect of some key clinical variables on neovascularisation in muscle flaps in an animal model. METHODOLOGY: The pectoralis profundus was raised in 60 rats and covered with a skin graft. Fifteen rats were allocated to each of the following groups: separation of the flap from the skin inset (S), inflammation by inoculation with Staphylococcus aureus (I), flap elevation with harmonic scalpel (H) and preservation of the motor nerve (N) as well as compared to controls (C)...
April 23, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29776002/the-chaos-of-hospitalisation-for-patients-with-critical-limb-ischaemia-approaching-major-amputation
#3
Susan Monaro, Sandra West, Jana Pinkova, Janice Gullick
AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families when major amputation has been advised for critical limb ischaemia (CLI). BACKGROUND: CLI creates significant burden to the health system and the family, particularly as the person with CLI approaches amputation. Major amputation is often offered as a late intervention for CLI in response to the marked deterioration of an ischaemic limb, and functional decline from reduced mobility, intractable pain, infection and/or toxaemia...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29772318/endovascular-management-of-a-large-persistent-sciatic-artery-aneurysm
#4
Tazo Inui, Andrew Picel, Andrew Barleben, John S Lane
The persistent sciatic artery (PSA) is a remnant of the fetal circulatory system that is preserved in less than 0.1% of the population. Up to 60% of patients with this vascular anomaly will go on to development of a PSA aneurysm (PSAA), which can produce a variety of symptoms including neuropathy, claudication, and acute limb-threatening ischemia. Historical management is by open operation and interposition grafting, which can be highly morbid. We describe successful management of a large, symptomatic PSAA by endovascular stent-grafting with intermediate term follow-up...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29761295/a-startling-acoustic-stimulus-facilitates-voluntary-lower-extremity-movements-and-automatic-postural-responses-in-people-with-chronic-stroke
#5
Milou J M Coppens, Jolanda M B Roelofs, Nicole A J Donkers, Jorik Nonnekes, Alexander C H Geurts, Vivian Weerdesteyn
A startling acoustic stimulus (SAS) involuntary releases prepared movements at accelerated latencies, known as the StartReact effect. Previous work has demonstrated intact StartReact in paretic upper extremity movements in people after stroke, suggesting preserved motor preparation. The question remains whether motor preparation of lower extremity movements is also unaffected after stroke. Here, we investigated StartReact effects on ballistic lower extremity movements and on automatic postural responses (APRs) following perturbations to standing balance...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29748592/novel-erythrocyte-clumps-revealed-by-an-orphan-gene-newtic1-in-circulating-blood-and-regenerating-limbs-of-the-adult-newt
#6
Roman M Casco-Robles, Akihiko Watanabe, Ko Eto, Kazuhito Takeshima, Shuichi Obata, Tsutomu Kinoshita, Takashi Ariizumi, Kei Nakatani, Tomoaki Nakada, Panagiotis A Tsonis, Martin M Casco-Robles, Keisuke Sakurai, Kensuke Yahata, Fumiaki Maruo, Fubito Toyama, Chikafumi Chiba
The newt, a group of urodele amphibians, has outstanding ability to repeatedly regenerate various body parts, even in the terrestrial life-stage. In this animal, when the limb is amputated, a cell mass named the blastema appears on the stump and eventually gives rise to a new functional limb. Erythrocytes (red blood cells) in most non-mammalian vertebrates, including the newt, preserve their nucleus throughout their life-span, although physiological roles of such nucleated erythrocytes, other than oxygen delivery, are not known...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741098/monophosphoryl-lipid-a-prevents-impairment-of-medullary-thick-ascending-limb-hco-3-absorption-and-improves-plasma-hco-3-concentration-in-septic-mice
#7
Bruns A Watts, Thampi George, Edward R Sherwood, David W Good
Metabolic acidosis is the most common acid-base disorder in septic patients and is associated with increased mortality. Previously we demonstrated that sepsis induced by cecal ligation and puncture (CLP) impairs HCO3 - absorption in the MTAL by: 1) decreasing the intrinsic HCO3 - absorptive capacity, and 2) enhancing inhibition of HCO3 - absorption by LPS through upregulation of TLR4 signaling. Both effects depend on ERK activation. Monophosphoryl lipid A (MPLA) is a detoxified TLR4 agonist that enhances innate antimicrobial immunity and improves survival following sepsis...
May 9, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29738486/shoe-insole-technology-for-injury-prevention-in-walking
#8
REVIEW
Hanatsu Nagano, Rezaul K Begg
Impaired walking increases injury risk during locomotion, including falls-related acute injuries and overuse damage to lower limb joints. Gait impairments seriously restrict voluntary, habitual engagement in injury prevention activities, such as recreational walking and exercise. There is, therefore, an urgent need for technology-based interventions for gait disorders that are cost effective, willingly taken-up, and provide immediate positive effects on walking. Gait control using shoe-insoles has potential as an effective population-based intervention, and new sensor technologies will enhance the effectiveness of these devices...
May 8, 2018: Sensors
https://www.readbyqxmd.com/read/29733992/neuronavigation-guided-corticospinal-tract-mapping-in-brainstem-tumor-surgery-better-preservation-of-motor-function
#9
Zhibao Li, Mingran Wang, Liwei Zhang, Xing Fan, Xiaorong Tao, Lei Qi, Miao Ling, Xiong Xiao, Yuliang Wu, Dongze Guo, Hui Qiao
BACKGROUND: A new method in brainstem surgery, neuronavigation (NN)-guided corticospinal tract (CST) mapping, was used in a retrospective study of patients undergoing brainstem tumor surgery. METHODS: We studied 40 patients with a brainstem tumor who were enrolled in this study. Patients whose worst preoperative muscle strength of the four limbs was greater than three levels from normal on the Lovett scale were divided into two groups: a treatment group of 21 patients that included NN-guided CST mapping and routine intraoperative neurophysiology monitoring (IONM), and a control group of 19 patients that included routine NN and routine IONM...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29733702/a-new-type-of-familial-partial-lipodystrophy-distinctive-fat-distribution-and-proteinuria
#10
Banu Yurekli, Nilufer Ozdemir Kutbay, Canan Altay, Sadiye Mehtat Unlu, Sait Sen, Huseyin Onay, Tahir Atik, Baris Akinci
PURPOSE: To describe an interesting subtype of familial partial lipodystrophy (FPLD). METHODS: The phenotype of this distinctive FPLD subtype was studied in three Turkish female siblings. RESULTS: Mutation testing was negative for the genes associated with lipodystrophy syndromes. In MRI studies, fat loss was prominent in the posterior aspects of the proximal lower limbs, whilst some fat was preserved in the anterior, medial and lateral aspects...
May 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29733410/perioperative-multimodal-evaluation-and-surgical-tactics-of-tumor-related-epilepsy-2-dimensional-operative-video
#11
Chengxin Ma, Rui Feng, N U Farrukh Hameed, Jie Zhang, Dongxiao Zhuang, Jinsong Wu
Treatment of tumor-related epilepsy (TRE), especially for tumors near critical areas, requires surgeons to strike a balance between the epileptic benefit and functional outcome after surgery. Here, we present a case in which multimodal evaluation facilitated the achievement of such surgical balance. Informed patient consent was obtained. A 17-yr-old female presented with seizure attacks for 2 yr. Magnetic resonance imaging (MRI) revealed a right parietal mass lesion with hypointense signal on T1W imaging, hyperintense signal on T2W imaging, and homogeneous enhancement...
May 4, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29733065/impacto-de-la-revascularizaci%C3%A3-n-y-factores-asociados-en-el-salvamento-de-la-extremidad-en-pacientes-con-pie-diab%C3%A3-tico
#12
Carlos A Hinojosa, Estefanía Boyer-Duck, Javier E Anaya-Ayala, Ana E Núñez-Salgado, Hugo Laparra-Escareno, René Lizola
Introducción: El pie diabético es causa frecuente de hospitalización. Objetivo: Examinar el impacto de la revascularización en la preservación de los miembros inferiores. Método: Estudio retrospectivo de pacientes diabéticos con úlceras en el pie. Se evaluó extensión del tejido perdido conforme las clasificaciones PEDIS y de Wagner, así como indicaciones y técnicas de revascularización. Los factores involucrados en la amputación mayor y el salvamento de la extremidad fueron evaluados por pruebas Fisher y chi cuadrado...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29724252/synthetic-versus-autologous-reconstruction-syn-var-of-the-medial-patellofemoral-ligament-a-study-protocol-for-a-randomised-controlled-trial
#13
Adam Tucker, Sam McMahon, Bronwyn McArdle, Bridgeen Rutherford, Danny Acton
BACKGROUND: Recurrent patellar instability incidence is 5.8/100,000 population, and recurrent dislocations are reported in the range of 15-80%. Recurrent instability is multifactorial and can be associated with disorder of limb alignment, osseous development, congruity of the patella in the trochlea and soft tissue static and dynamic constraints. The multifactorial aetiology makes management challenging, and a lack studies in a heterogeneous population with robust clinical outcomes compounds this further...
May 3, 2018: Trials
https://www.readbyqxmd.com/read/29715354/effect-of-atropine-with-propofol-vs-atropine-with-atracurium-and-sufentanil-on-oxygen-desaturation-in-neonates-requiring-nonemergency-intubation-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Xavier Durrmeyer, Sophie Breinig, Olivier Claris, Pierre Tourneux, Cénéric Alexandre, Elie Saliba, Alain Beuchée, Camille Jung, Corinne Levy, Laetitia Marchand-Martin, Marie-Odile Marcoux, Agnes Dechartres, Claude Danan
Importance: Propofol or a combination of a synthetic opioid and muscle relaxant are both recommended for premedication before neonatal intubation but have yet to be compared. Objective: To compare prolonged desaturation during neonatal nasotracheal intubation after premedication with atropine-propofol vs atropine-atracurium-sufentanil treatment. Design, Setting, and Participants: Multicenter, double-blind, randomized clinical trial (2012-2016) in 6 NICUs in France that included 173 neonates requiring nonemergency intubation...
May 1, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29710025/-a-survivor-of-hodgkin-lymphoma-manifesting-dropped-head-syndrome-as-a-late-onset-complication-of-radiotherapy-a-case-report
#15
Misako Kaido, Yoshihito Yuasa, Hiroshi Ikeda
We report the case of a 50-year-old female survivor of Hodgkin lymphoma (HL), who developed dropped head syndrome (DHS). The patient was diagnosed with HL at 20 years of age, and underwent chemo-radiotherapy, which led to complete remission. Undergoing supplemental therapy for post-radiation hypothyroidism, she had twin babies. She noticed white stains on her neck at the age of 30, and the decolored area gradually expanded. Sixteen years after the radiotherapy (RT), her posterior neck muscle strength began to decline...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29706552/flap-choice-does-not-affect-complication-rates-or-functional-outcomes-following-extremity-soft-tissue-sarcoma-reconstruction
#16
Jelena Slump, Stefan O P Hofer, Peter C Ferguson, Jay S Wunder, Anthony M Griffin, Harald J Hoekstra, Esther Bastiaannet, Anne C O'Neill
BACKGROUND: Flap reconstruction plays an essential role in facilitating limb preservation in patients with extremity soft tissue sarcoma (ESTS). However, the effect of flap choice on the rates of postoperative complications and functional outcomes has not been clearly established. This study directly compares the outcomes of free and pedicled flap reconstructions in patients with ESTS. METHODS: Two hundred sixty-six patients who underwent flap reconstruction following ESTS resection were included...
April 12, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29705080/no-relationship-between-mild-limb-length-discrepancy-and-spine-hip-or-knee-degenerative-disease-in-a-large-cadaveric-collection
#17
Raymond W Liu, Jonathan J Streit, Douglas S Weinberg, Jeremy D Shaw, Elyse LeeVan, Daniel R Cooperman
BACKGROUND: Although asymptomatic mild limb length discrepancy (LLD) in children is generally treated non-operatively, there is limited high quality follow up data to support this recommendation. HYPOTHESIS: We hypothesized that there would be no association between LLD and arthritic changes with mild limb length discrepancy. MATERIALS AND METHODS: We studied 576 well-preserved cadaveric skeletons ranging from 40 to 79 years of age. Limb length discrepancy was based on combined femoral and tibial lengths measured using digital calipers...
April 26, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29701407/creative-vascular-access-construction-in-same-patient
#18
Pedro Pinto Sousa, Paulo Almeida, Pedro Sá Pinto, Rui Almeida
INTRODUCTION: Creating and maintaining a functional vascular access(VA) is a critical factor in the survival of a dialysis patient. However, it will not function forever, implying a creative attitude from the vascular surgeon either to maintain its functionality or built a new one wherever possible, being it autologous or synthetic. METHODS: Describe the VA history of a 59years-old male with morbid obesity and end-stage chronic kidney disease. RESULTS: His VA construction started in2012 with failed attempts in both forearms until a functional brachiocephalic artery-venous fistula(AVF) in the right upper limb was achieved, but was deemed to ligation as severe venous hypertension secondary to central venous disease related to CVC use...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701383/aneurysms-of-the-upper-limb-review-of-an-experience
#19
Mafalda Correia, Luís Antunes, Óscar Gonçalves
INTRODUCTION: True arterial aneurysms of the upper limb are rare and their treatment is intended to avoid complications as distal embolization or compression of surrounding neurovascular structures. The purpose of this study is to review the experience in the surgical treatment of true arterial aneurysms of the upper limb. METHODS: Retrospective study of patients with true arterial aneurysms of the upper limb surgically treated between January 2007 and August 2017...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700404/preservation-of-rat-limbs-by-hyperbaric-carbon-monoxide-and-oxygen
#20
Naoyuki Hatayama, Shuichi Hirai, Munekazu Naito, Hayato Terayama, Jun Araki, Hiroki Yokota, Masayuki Matsushita, Xiao-Kang Li, Masahiro Itoh
Cold ischemia times ranging from <6 h to as long as 24 h are generally quoted as the limits for attempting the replantation of amputated extremities. In this study, we aimed to assess the effect of hyperbaric carbon monoxide (CO) and oxygen (O2 ) on rat limb preservation. Donor rat limbs were preserved in a chamber filled with hyperbaric CO and O2 for 3 days (CO + O2 3 days) or 7 days (CO + O2 7 days). Positive and negative control groups were created by using non-preserved limbs (NP) and limbs wrapped in saline-moistened gauze for 3 days (SMG 3 days), respectively...
April 26, 2018: Scientific Reports
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