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https://www.readbyqxmd.com/read/28641566/is-it-possible-to-treat-osteosarcoma-using-oligonucleotides-confined-into-controlled-release-drug-delivery-systems
#1
Savas Topuk, Yener Akyuva, Numan Karaaslan, Cagri Ata Mutlu, Ibrahim Yilmaz, Mehmet Isyar, Duygu Yasar Sirin, Semih Akkaya, Hanefi Özbek, Mahir Mahirogullari
PURPOSE: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small interfering-/micro- ribonucleic acid. METHODS: Without any language preference, we searched US National Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1843 to May 25, 2016 and traced all the references of incorporated documents...
June 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28639700/systematic-review-health-related-quality-of-life-in-children-and-adults-with-eosinophilic-oesophagitis-instruments-for-measurement-and-determinant-factors
#2
REVIEW
A J Lucendo, L Arias-González, J Molina-Infante, Á Arias
BACKGROUND: Several measures have been used to assess the health-related quality of life (HRQoL) of patients with eosinophilic oesophagitis (EoE). AIMS: To systematically review these HRQoL measures, to appraise measurement properties of specific instruments and to evaluate determinant factors influencing HRQoL in paediatric and adult EoE patients. METHODS: We searched the PubMed, Embase, Scopus, Web of Science (WOS) and PsycINFO databases for documents providing original information on the development of measurement tools and/or evaluation of HRQoL outcomes in EoE patients of all ages...
June 22, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28637055/a-pilot-study-on-professional-documentation-do-we-write-from-a-strengths-perspective
#3
Matthew J Braun, Winnie Dunn, Scott D Tomchek
Purpose: There is growing evidence supporting the use of strengths-based practices when serving families. The purpose of this study was to examine the use of strengths-based approaches in the context of written professional documentation. We specifically explored whether or not interdisciplinary clinicians in one university-based medical center clinic write from a strengths perspective (e.g., writing focuses on abilities rather than on deficits) when documenting child behavior in autism diagnostic clinics...
June 20, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28633441/bioqueue-a-novel-pipeline-framework-to-accelerate-bioinformatics-analysis
#4
Li Yao, Heming Wang, Yuanyuan Song, Guangchao Sui
Motivation: With the rapid development of Next-Generation Sequencing, a large amount of data is now available for bioinformatics research. Meanwhile, the presence of many pipeline frameworks makes it possible to analyse these data. However, these tools concentrate mainly on their syntax and design paradigms, and dispatch jobs based on users' experience about the resources needed by the execution of a certain step in a protocol. As a result, it is difficult for these tools to maximize the potential of computing resources, and avoid errors caused by overload, such as memory overflow...
June 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28630972/using-the-international-classification-of-functioning-disability-and-health-in-assessment-and-intervention-of-school-aged-children-with-language-impairments
#5
Carol Westby, Karla N Washington
Purpose: The aim of this tutorial is to support speech-language pathologists' (SLPs') application of the International Classification of Functioning, Disability and Health (ICF) in assessment and treatment practices with children with language impairment. Method: This tutorial reviews the framework of the ICF, describes the implications of the ICF for SLPs, distinguishes between students' capacity to perform a skill in a structured context and the actual performance of that skill in naturalistic contexts, and provides a case study of an elementary school child to demonstrate how the principles of the ICF can guide assessment and intervention...
June 18, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28625288/no-96-the-reproductive-care-of-women-living-with-hepatitis-c-infection
#6
Marc Boucher, Andrée Gruslin
OBJECTIVE: hepatitis C virus (HCV) is an increasingly important public health problem worldwide. Health care workers providing care to women of childbearing age are uniquely placed in their practices to identify a significant proportion of at-risk patients and to provide appropriate screening and counselling. The primary objective of this guideline is to provide accurate, current information to those offering reproductive care to women living with HCV. This document is also intended to raise awareness of HCV in both the medical and general populations...
July 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28623665/position-paper-on-olfactory-dysfunction
#7
T Hummel, K L Whitcroft, P Andrews, A Altundag, C Cinghi, R M Costanzo, M Damm, J Frasnelli, H Gudziol, N Gupta, A Haehner, E Holbrook, S C Hong, D Hornung, K B Hüttenbrink, R Kamel, M Kobayashi, I Konstantinidis, B N Landis, D A Leopold, A Macchi, T Miwa, R Moesges, J Mullol, C A Mueller, G Ottaviano, G C Passali, C Philpott, J M Pinto, V J Ramakrishnan, P Rombaux, Y Roth, R A Schlosser, B Shu, G Soler, P Stjärne, B A Stuck, J Vodicka, A Welge-Luessen
BACKGROUND: Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration and death. However, translational research in this field is limited by heterogeneity in methodological approach, including definitions of impairment, improvement and appropriate assessment techniques. Accordingly, effective treatments for smell loss are limited. In an effort to encourage high quality and comparable work in this field, among others, we propose the following ideas and recommendations...
June 17, 2017: Rhinology
https://www.readbyqxmd.com/read/28621012/supporting-people-with-aphasia-to-settle-into-a-new-way-to-be-speech-and-language-therapists-views-on-providing-psychosocial-support
#8
Sarah Northcott, Alan Simpson, Becky Moss, Nafiso Ahmed, Katerina Hilari
BACKGROUND: People with aphasia are at risk of becoming depressed and isolated. Online surveys have found that the majority of speech and language therapists (SLTs) lack confidence in addressing the psychological needs of people with aphasia. AIMS: To explore how SLTs conceptualize the scope of their role; barriers and facilitators to SLTs addressing psychosocial needs; and SLTs' experiences of specialist training and support, and working with mental health professionals (MHPs)...
June 16, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28620876/english-orthographic-learning-in-chinese-l1-young-efl-beginners
#9
Yu-Lin Cheng
English orthographic learning, among Chinese-L1 children who were beginning to learn English as a foreign language, was documented when: (1) only visual memory was at their disposal, (2) visual memory and either some letter-sound knowledge or some semantic information was available, and (3) visual memory, some letter-sound knowledge and some semantic information were all available. When only visual memory was available, orthographic learning (measured via an orthographic choice test) was meagre. Orthographic learning was significant when either semantic information or letter-sound knowledge supplemented visual memory, with letter-sound knowledge generating greater significance...
June 15, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28613384/communication-skills-training-for-mental-health-professionals-working-with-people-with-severe-mental-illness
#10
REVIEW
Alexia Papageorgiou, Yoon K Loke, Michelle Fromage
BACKGROUND: Research evidence suggests that both mental health professionals and people with severe mental health illness such as schizophrenia or schizoaffective disorder find it difficult to communicate with each other effectively about symptoms, treatments and their side effects so that they reach a shared understanding about diagnosis, prognosis and treatment. Effective use of communication skills in mental health interactions could be associated with increased patient satisfaction and adherence to treatment...
June 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28611885/american-association-for-emergency-psychiatry-task-force-on-medical-clearance-of-adult-psychiatric-patients-part-ii-controversies-over-medical-assessment-and-consensus-recommendations
#11
REVIEW
Michael P Wilson, Kimberly Nordstrom, Eric L Anderson, Anthony T Ng, Leslie S Zun, Jennifer M Peltzer-Jones, Michael H Allen
INTRODUCTION: The emergency medical evaluation of psychiatric patients presenting to United States emergency departments (ED), usually termed "medical clearance," often varies between EDs. A task force of the American Association for Emergency Psychiatry (AAEP), consisting of physicians from emergency medicine, physicians from psychiatry and a psychologist, was convened to form consensus recommendations for the medical evaluation of psychiatric patients presenting to U.S.EDs. METHODS: The task force reviewed existing literature on the topic of medical evaluation of psychiatric patients in the ED and then combined this with expert consensus...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28606104/unlocking-echocardiogram-measurements-for-heart-disease-research-through-natural-language-processing
#12
Olga V Patterson, Matthew S Freiberg, Melissa Skanderson, Samah J Fodeh, Cynthia A Brandt, Scott L DuVall
BACKGROUND: In order to investigate the mechanisms of cardiovascular disease in HIV infected and uninfected patients, an analysis of echocardiogram reports is required for a large longitudinal multi-center study. IMPLEMENTATION: A natural language processing system using a dictionary lookup, rules, and patterns was developed to extract heart function measurements that are typically recorded in echocardiogram reports as measurement-value pairs. Curated semantic bootstrapping was used to create a custom dictionary that extends existing terminologies based on terms that actually appear in the medical record...
June 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28602605/vaccination-in-newly-arrived-immigrants-to-the-european-union
#13
Roman Prymula, Jana Shaw, Roman Chlibek, Ingrid Urbancikova, Karolina Prymulova
The challenge of assimilating millions of immigrants in the European region each year presents significant socioeconomic issues. Among them is the threat of vaccine preventable diseases (VPDs) disease transmission within immigrant groups and the broader population given the permeability of nation state borders. A total of 3.8 million people immigrated to the European Union (EU) in 2014, among those were 1.6 million non-EU nationals. While vaccines have markedly reduced the transmission of disease, clusters of under-vaccinated individuals potentiate the rapid transmission of once-eradicated or controlled diseases...
June 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28596702/document-retrieval-on-repetitive-string-collections
#14
Travis Gagie, Aleksi Hartikainen, Kalle Karhu, Juha Kärkkäinen, Gonzalo Navarro, Simon J Puglisi, Jouni Sirén
Most of the fastest-growing string collections today are repetitive, that is, most of the constituent documents are similar to many others. As these collections keep growing, a key approach to handling them is to exploit their repetitiveness, which can reduce their space usage by orders of magnitude. We study the problem of indexing repetitive string collections in order to perform efficient document retrieval operations on them. Document retrieval problems are routinely solved by search engines on large natural language collections, but the techniques are less developed on generic string collections...
2017: Information Retrieval
https://www.readbyqxmd.com/read/28588356/molecular-pathogenesis-of-alzheimer-s-disease-an-update
#15
REVIEW
Alfredo Sanabria-Castro, Ileana Alvarado-Echeverría, Cecilia Monge-Bonilla
Dementia is a chronic or progressive syndrome, characterized by impaired cognitive capacity beyond what could be considered a consequence of normal aging. It affects the memory, thinking process, orientation, comprehension, calculation, learning ability, language, and judgment; although awareness is usually unaffected. Alzheimer's disease (AD) is the most common form of dementia; symptoms include memory loss, difficulty solving problems, disorientation in time and space, among others. The disease was first described in 1906 at a conference in Tubingen, Germany by Alois Alzheimer...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28585453/cognitive-outcomes-following-anti-n-methyl-d-aspartate-receptor-encephalitis-a-systematic-review
#16
Gemma L McKeon, Gail A Robinson, Alexander E Ryan, Stefan Blum, David Gillis, Carsten Finke, James G Scott
INTRODUCTION: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an immune-mediated neurological disorder that (among other severe neuropsychiatric symptoms) affects cognition. This study aimed to summarize current knowledge regarding the rates, nature, and predictors of neuropsychological dysfunction in patients recovering from anti-NMDAR encephalitis. METHOD: A systematic review of studies describing neuropsychological outcomes following anti-NMDAR encephalitis was conducted...
June 6, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28584867/utilization-and-acceptance-of-virtual-patients-in-veterinary-basic-sciences-the-vetvip-project
#17
Christin Kleinsorgen, Marta Kankofer, Zbigniew Gradzki, Mira Mandoki, Tibor Bartha, Maren von Köckritz-Blickwede, Hassan Y Naim, Martin Beyerbach, Andrea Tipold, Jan P Ehlers
Context: In medical and veterinary medical education the use of problem-based and cased-based learning has steadily increased over time. At veterinary faculties, this development has mainly been evident in the clinical phase of the veterinary education. Therefore, a consortium of teachers of biochemistry and physiology together with technical and didactical experts launched the EU-funded project "vetVIP", to create and implement veterinary virtual patients and problems for basic science instruction. In this study the implementation and utilization of virtual patients occurred at the veterinary faculties in Budapest, Hannover and Lublin...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28583125/considerations-and-guidance-in-designing-equity-relevant-clinical-trials
#18
EDITORIAL
Lawrence Mbuagbaw, Theresa Aves, Beverley Shea, Janet Jull, Vivian Welch, Monica Taljaard, Manosila Yoganathan, Regina Greer-Smith, George Wells, Peter Tugwell
Health research has documented disparities in health and health outcomes within and between populations. When these disparities are unfair and avoidable they may be referred to as health inequities. Few trials attend to factors related to health inequities, and there is limited understanding about how to build consideration of health inequities into trials. Due consideration of health inequities is important to inform the design, conduct and reporting of trials so that research can build evidence to more effectively address health inequities and importantly, ensure that inequities are not aggravated...
June 5, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28579872/medicons-toward-clinical-examination-diagrams-standardization-in-medical-documentation
#19
Georgios Pafitanis, Michalis Hadjiandreou, Leo Withers, Helen Dent
BACKGROUND: Electronic patient records (EPRs) allow efficient and accurate medical documentation. Diagrams have traditionally been used to document clinical signs in patient notes. The interpretation of these diagrams may vary among doctors across a range of specialties, but this has never been tested previously. This study investigated how common diagrams were interpreted and explored the use of digitalized diagrams - Medicons in creating a common language to be used in digital clinical examination proformas...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28576748/automatic-recognition-of-symptom-severity-from-psychiatric-evaluation-records
#20
Travis R Goodwin, Ramon Maldonado, Sanda M Harabagiu
This paper presents a novel method for automatically recognizing symptom severity by using natural language processing of psychiatric evaluation records to extract features that are processed by machine learning techniques to assign a severity score to each record evaluated in the 2016 RDoC for Psychiatry Challenge from CEGS/N-GRID. The natural language processing techniques focused on (a) discerning the discourse information expressed in questions and answers; (b) identifying medical concepts that relate to mental disorders; and (c) accounting for the role of negation...
May 30, 2017: Journal of Biomedical Informatics
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