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"Cluster headache"

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https://www.readbyqxmd.com/read/28074859/identifying-a-gene-expression-signature-of-cluster-headache-in-blood
#1
Else Eising, Nadine Pelzer, Lisanne S Vijfhuizen, Boukje de Vries, Michel D Ferrari, Peter A C 't Hoen, Gisela M Terwindt, Arn M J M van den Maagdenberg
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) or chronic (n = 20) cluster headache in comparison with headache-free controls (n = 20)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034970/cardiovascular-risk-factors-in-cluster-headache
#2
S Santos Lasaosa, E Bellosta Diago, J Navarro Calzada, A Velázquez Benito
BACKGROUND:  Patients with cluster headache tend to have a dysregulation of systemic blood pressure such as increased blood pressure variability and decreased nocturnal dipping. This pattern of nocturnal nondipping is associated with end-organ damage and increased risk of cardiovascular disease. OBJECTIVE:  To determine if cluster headache is associated with a higher risk of cardiovascular disease. METHODS:  Cross-sectional study of 33 cluster headache patients without evidence of cardiovascular disease and 30 age- and gender-matched healthy controls...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27995704/treatment-of-intractable-chronic-cluster-headache-by-occipital-nerve-stimulation-a-cohort-of-51-patients
#3
S Miller, L Watkins, M Matharu
BACKGROUND AND PURPOSE: Chronic cluster headache is a rare, highly disabling primary headache condition. When medically intractable, occipital nerve stimulation can offer effective treatment. Open-label series have provided data on small cohorts only. METHODS: We analyzed 51 subjects to evaluate the long-term outcomes of highly intractable chronic cluster headache with occipital nerve stimulation. Patients with intractable chronic cluster headache were implanted with occipital nerve stimulators during the period 2007-2014...
December 20, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27957625/a-genome-wide-analysis-in-cluster-headache-points-to-neprilysin-and-pacap-receptor-gene-variants
#4
Elena Bacchelli, Maria Michela Cainazzo, Cinzia Cameli, Simona Guerzoni, Angela Martinelli, Michele Zoli, Elena Maestrini, Luigi Alberto Pini
BACKGROUND: Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been identified. The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms. METHODS: We have performed a genome-wide association study (GWAS) in a clinically well-defined cohort of 99 Italian patients with CH and in a control sample of 360 age-matched sigarette smoking healthy individuals, using the Infinium PsychArray (Illumina), which combines common highly-informative genome-wide tag SNPs and exonic SNPs...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27940880/cgrp-in-human-models-of-primary-headaches
#5
Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
OBJECTIVE: To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. DISCUSSION: Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27925184/a-case-report-about-cluster-tic-syndrome-due-to-venous-compression-of-the-trigeminal-nerve
#6
Ilse de Coo, J Marc C van Dijk, Jan D M Metzemaekers, Joost Haan
BACKGROUND: The term "cluster-tic syndrome" is used for the rare ipsilateral co-occurrence of attacks of cluster headache and trigeminal neuralgia. Medical treatment should combine treatment for cluster headache and trigeminal neuralgia, but is very often unsatisfactory. CASE: Here, we describe a 41-year-old woman diagnosed with cluster-tic syndrome who underwent microvascular decompression of the trigeminal nerve, primarily aimed at the "trigeminal neuralgia" part of her pain syndrome...
December 7, 2016: Headache
https://www.readbyqxmd.com/read/27910088/the-efficacy-of-greater-occipital-nerve-blockade-in-chronic-migraine-a-placebo-controlled-study
#7
H L Gul, A O Ozon, O Karadas, G Koc, L E Inan
OBJECTIVE: GON blockade with local anesthetics is an effective treatment for a group of headaches, such as cervicogenic headache, cluster headache, occipital neuralgia, migraine. Our aim was to evaluate the efficacy of greater occipital nerve (GON) blockade in patients with chronic migraine (CM) by using a control group. MATERIALS AND METHODS: We included 44 CM patients and randomly divide the patients into two groups, as group A (bupivacaine) and group B (placebo) to our study...
December 2, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27861832/cluster-headache-with-accompanying-migraine-like-features-a-possible-clinical-phenotype
#8
Arens Taga, Marco Russo, Gian Camillo Manzoni, Paola Torelli
BACKGROUND: There are limited literature data on migraine-like accompanying features (MLF) in patients with cluster headache (CH). These symptoms are frequently reported by patients and may delay CH diagnosis. OBJECTIVE: The aim of the present study was to investigate the occurrence of migraine-like symptoms in an Italian case series of CH patients and to determine whether these features influence the clinical phenotype of CH. METHODS: A cross-sectional study was performed in all consecutive patients referred to the Parma Headache Centre between 1975 and 2013 affected by CH; the cases were subsequently reviewed applying the ICHD3-beta criteria...
November 10, 2016: Headache
https://www.readbyqxmd.com/read/27861830/hemicrania-continua-beneficial-effect-of-non-invasive-vagus-nerve-stimulation-in-a-patient-with-a-contraindication-for-indomethacin
#9
Ozan Eren, Andreas Straube, Florian Schöberl, Christoph Schankin
Hemicrania continua (HC) is a primary chronic headache disorder, characterized by a continuous and strictly unilateral headache, with possible cranial autonomic symptoms during episodes of pain exacerbation. The unilateral headache generally responds well to indomethacin; however, continuous indomethacin intake is often not tolerated due to severe adverse effects, like hypertension, gastrointestinal discomfort (especially if combined with aspirin), slightly increased risk of vascular events, and bronchial spasms...
November 11, 2016: Headache
https://www.readbyqxmd.com/read/27834408/-headache-classification-and-diagnosis
#10
P A T Carbaat, E G M Couturier
There are many types of headache and, moreover, many people have different types of headache at the same time. Adequate treatment is possible only on the basis of the correct diagnosis. Technically and in terms of content the current diagnostics process for headache is based on the 'International Classification of Headache Disorders' (ICHD-3-beta) that was produced under the auspices of the International Headache Society. This classification is based on a distinction between primary and secondary headaches...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27815646/ipsilateral-alteration-of-resting-state-activity-suggests-that-cortical-dysfunction-contributes-to-the-pathogenesis-of-cluster-headache
#11
Péter Faragó, Nikoletta Szabó, Eszter Tóth, Bernadett Tuka, András Király, Gergő Csete, Árpád Párdutz, Délia Szok, János Tajti, Csaba Ertsey, László Vécsei, Zsigmond Tamás Kincses
The pathomechanism of cluster headache (CH) is not entirely understood, but central and peripheral components were suggested. A recent report showed that transcranial magnetic stimulation measured cortical excitability was increased in the hemisphere ipsilalteral to the pain. In the current study we set out to investigate the amplitude of resting brain fMRI activity to find signatures of the increased excitability. High resolution T1 weighted and resting state functional MRI images were acquired from seventeen patients with CH in pain free period and from twenty-six healthy volunteers...
November 4, 2016: Brain Topography
https://www.readbyqxmd.com/read/27786243/new-strategies-for-the-treatment-and-prevention-of-primary-headache-disorders
#12
REVIEW
Nathaniel M Schuster, Alan M Rapoport
The primary headache disorders, which include migraine, cluster headache and tension-type headache, are among the most common diseases and leading causes of disability worldwide. The available treatment options for primary headache disorders have unsatisfactory rates of efficacy, tolerability and patient adherence. In this Review, we discuss promising new approaches for the prevention of primary headache disorders, such as monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor, and small-molecule CGRP receptor antagonists...
October 27, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27747725/high-dose-verapamil-in-episodic-and-chronic-cluster-headaches-and-cardiac-adverse-events-is-it-as-safe-as-we-think
#13
Joachim Alexandre, Xavier Humbert, Marion Sassier, Paul Milliez, Antoine Coquerel, Sophie Fedrizzi
Cluster headache (CH) is a primary headache disorder with relatively effective treatments. Although few sufficiently controlled trials are available, verapamil is recommended as the first-line prophylactic drug for CH by the French Headache Society (with a low level of evidence, level B) and by the EFNS (European Federation of Neurological Societies, level A). Daily doses of more than 480 mg (and up to 1200 mg daily) are frequently used off-label, while 360 mg daily is the only dosage to have demonstrated its effectiveness in a double-blind trial against placebo, and the usual label posology used by cardiologists is 240 mg daily in hypertension...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27698153/long-term-use-of-daily-sumatriptan-injections-in-severe-drug-resistant-chronic-cluster-headache
#14
Werner R Verslegers, Massimo Leone, Alberto Proietti Cecchini
No abstract text is available yet for this article.
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27697849/occipital-nerve-stimulation-improves-the-quality-of-life-in-medically-intractable-chronic-cluster-headache-results-of-an-observational-prospective-study
#15
Denys Fontaine, Serge Blond, Christian Lucas, Jean Regis, Anne Donnet, Stéphane Derrey, Evelyne Guegan-Massardier, Bechir Jarraya, Bich Dang-Vu, Frederic Bourdain, Dominique Valade, Caroline Roos, Christèle Creach, Stéphan Chabardes, Pierric Giraud, Jimmy Voirin, Jocelyne Bloch, Alda Rocca, Sophie Colnat-Coulbois, Francois Caire, Coralie Roger, Sylvie Romettino, Michel Lanteri-Minet
BACKGROUND: Occipital nerve stimulation (ONS) has been proposed to treat chronic medically-intractable cluster headache (iCCH) in small series of cases without evaluation of its functional and emotional impacts. METHODS: We report the multidimensional outcome of a large observational study of iCCH patients, treated by ONS within a nationwide multidisciplinary network (https://clinicaltrials.gov NCT01842763), with a one-year follow-up. Prospective evaluation was performed before surgery, then three and 12 months after...
October 3, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27695567/anterior-cervical-discectomy-and-fusion-with-titanium-cages-for-simple-or-multilevel-herniated-discs-and-spur-of-the-cervical-spine-report-of-2-cases-and-experience-in-bali
#16
G B Mahadewa Tjokorda, Golden Nyoman, Maliawan Sri, Mizuno Junichi
This report presents two cases of cervicobrachialgia and radiculopathy due to multiple cervical herniated discs and spur formation that dealt with anterior cervical discectomy and fusion (ACDF) using different titanium interbody cages. The description of the clinical presentation, magnetic resonance imaging (MRI) appearances and management strategy are discussed. Both cases showed chronic neck pain and radiating pain from the shoulder to the arm. They had a history of blurry vision, cluster head ache, weakness, and numbness on the shoulder for 2 years...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27694264/cluster-headache-and-depression
#17
Mark A Louter, Leopoldine A Wilbrink, Joost Haan, Erik W van Zwet, Willebrordus P J van Oosterhout, Frans G Zitman, Michel D Ferrari, Gisela M Terwindt
OBJECTIVE: As cluster headache (CH) is often referred to as "suicide headache," we wanted to assess the prevalence of depression in CH patients, and to investigate determinants of depression such as sleep disturbances. METHODS: In a cross-sectional, web-based, validated questionnaire study among 462 well-defined CH patients and 177 controls, we diagnosed CH according to the ICHD-III. We assessed depression using the Hospital Anxiety and Depression Scale (HADS-D) and the Center for Epidemiologic Studies Depression scale (CES-D) with supplementary questions to assess lifetime depression...
September 30, 2016: Neurology
https://www.readbyqxmd.com/read/27687372/transnasal-sphenopalatine-ganglion-block-for-the-treatment-of-postdural-puncture-headache-in-obstetric-patients
#18
Sheffield Kent, Gregory Mehaffey
STUDY OBJECTIVE: To demonstrate a possible alternative treatment for postdural puncture headache (PDPH). DESIGN: Postdural puncture headache is a common complication associated with neuraxial anesthesia and unintentional dural puncture. Epidural blood patch (EBP) is the standard therapy for PDPH but has risks including pain, dural puncture, and infection. Transnasal sphenopalatine ganglion block (SPGB) has been successfully used to treat migraine, cluster headache, and trigeminal neuralgia...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27678260/invasive-and-non-invasive-electrical-pericranial-nerve-stimulation-for-the-treatment-of-chronic-primary-headaches
#19
REVIEW
Kevin D'Ostilio, Delphine Magis
Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modulation which has been recently applied to headache management. In this review, we summarise recent advances in invasive and non-invasive neurostimulation techniques targeting pericranial structures for the treatment of chronic primary headaches, chiefly migraine and cluster headache: occipital nerve, supraorbital nerve, vagus nerve, and sphenopalatine ganglion stimulations...
November 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27678213/what-is-cluster-headache-fact-sheet-for-patients-and-their-families-a-publication-to-mark-cluster-headache-day-2016
#20
Paolo Rossi, J Whelan, A Craven, E Ruiz De La Torre
No abstract text is available yet for this article.
July 2016: Functional Neurology
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