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Luke Gerges, Dorota Popiolek, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study is to assess the utility of texture analysis of multiple MRI sequences for the differentiation of uterine leiomyomas and leiomyosarcomas. MATERIALS AND METHODS: Seventeen leiomyosarcomas and 51 leiomyomas undergoing MRI before resection were included. Whole-lesion volumes of interest were placed on T2-weighted images, contrast-enhanced T1-weighted images, and apparent diffusion coefficient (ADC) maps. The diagnostic performance of histogram metrics was assessed...
March 16, 2018: AJR. American Journal of Roentgenology
Eugene M Ko, Jonathan B McHugh
This clinicopathologic study of primary oral leiomyosarcoma of the buccal mucosa involves a literature review of 15 cases with the addition of our report of a case. The demographic details, tumor size, treatment and outcome are documented for all the cases. In addition, this review examines the histologic features of leiomyosarcoma while noting that differentiation from other spindle cell tumors can be challenging, underscoring the necessity of an immunohistochemical work up for an accurate diagnosis. The unpredictability of the clinical behavior of these aggressive tumors requires, at the very least, wide local surgical excision and prolonged follow up...
March 13, 2018: Head and Neck Pathology
Min Hyun Baek, Jeong Yeol Park, Yangsoon Park, Kyu Rae Kim, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: To investigate the expression of androgen receptor (AR) and its correlation with disease status and survival outcome in uterine leiomyosarcoma with other hormone receptors. METHODS: The medical records and paraffin blocks of 42 patients were reviewed. The immunohistochemical expression of AR, estrogen receptor (ER), progesterone receptor (PR), gonadotropin releasing hormone (GnRH), and cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1) were assessed using tissue microarray...
February 5, 2018: Journal of Gynecologic Oncology
Andrew J Gall, June E Olds, Arno Wünschmann, Laura E Selmic, James Rasmussen, Anne D Lewis
Reproductive lesions have been described in various nonhuman primate species, including rhesus macaques ( Macaca mulatta), cynomolgus macaques ( Macaca fascicularis), baboons ( Papio spp.), squirrel monkeys ( Saimiri sciureus), and chimpanzees ( Pan spp.); however, there are few publications describing reproductive disease and pathology in Japanese macaques ( Macaca fuscata). A retrospective evaluation of postmortem reports for two captive M. fuscata populations housed within zoos from 1982 through 2015 was completed, comparing reproductive diseases diagnosed by gross pathology and histopathology...
March 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Viktoria-Anna Nteli, Wolfgang Knauf, Anja Janton-Klein, Samer El-Safadi
Background: Uterine leiomyosarcoma (uLMS) is a rare tumor that accounts for 1% of all uterine malignancies. In spite of adequate surgical resection of uLMS, even in the early stage, patients remain at high risk for local and distant recurrence. Therefore, the treatment of advanced uLMS represents a considerable challenge. Methods: We report the case of a 47-year-old woman who presented with uLMS with abnormal vaginal bleeding. Results: The patient underwent a total hysterectomy and bilateral adnexectomy, which was followed by 1 year progression-free survival without adjuvant therapy...
January 2018: Case Reports in Oncology
Fouzia Siraj, Shruti Sharma, Chandra Bhushan Rai, Pawan Vasudeva
A 27-year-old male presented with a gradually increasing left scrotal mass. There was no significant past medical history. Ultrasonography of the left scrotum showed a hypoechoic, intratesticular mass with solid and cystic components. Laboratory investigations revealed normal serum levels of alpha-fetoprotein, beta human chorionic gonadotropin and lactate dehydrogenase. He underwent left high inguinal orchidectomy due to suspicion of testicular malignancy. After histopathologic examination and immunostaining, a diagnosis of high-grade primary testicular leimyosarcoma was ascertained...
March 2018: Turkish Journal of Urology
Marilla Dickfos, Stephanie B M Tan, Andrew R L Stevenson, Craig A Harris, Rachel Esler, Matthew Peters, David G Taylor
BACKGROUND: Over one-third of primary rectal cancers are locally advanced at diagnosis, and local recurrence of rectal cancer occurs at a rate of 3-10% following primary curative resection. Extended resectional surgery, including pelvic exenteration, is the only proven therapy with curative potential in the treatment of these cancers along with many other pelvic malignancies. A microscopically clear resection margin (R0 resection) is the predominant prognostic factor affecting overall and disease-free survival...
March 6, 2018: ANZ Journal of Surgery
Takao Sato, Kazuya Akahoshi, Naru Tomoeda, Norikatsu Kinoshita, Masaru Kubokawa, Kentaro Yodoe, Yuka Hiraki, Masafumi Oya, Hidetaka Yamamoto, Eikichi Ihara
There have been no reports of primary leiomyosarcoma of the stomach treated by endoscopic submucosal dissection (ESD). We report an extremely rare case of gastric leiomyosarcoma that was successfully treated by ESD. An asymptomatic 74-year-old female underwent esophagogastroduodenoscopy for screening in December 2013. A centrally depressed submucosal tumor 10 mm in diameter was detected at the posterior wall of the upper gastric body. Follow-up esophagogastroduodenoscopy conducted 5 months later showed that the tumor diameter had increased to 15 mm...
March 2, 2018: Clinical Journal of Gastroenterology
Gianluca Moroncini, Elena Maccaroni, Ilaria Fiordoliva, Chiara Pellei, Armando Gabrielli, Rossana Berardi
Lartruvo® (olaratumab) is a fully human immunoglobulin G subclass 1 (IgG1) monoclonal antibody that inhibits platelet-derived growth factor receptor alpha (PDGFRα). The antitumor activity of olaratumab has been tested in vitro and in vivo, and inhibition of tumor growth has been observed in cancer cell lines, including glioblastoma and leiomyosarcoma cells. It represents the first-in-class antibody to be approved by regulatory authorities for the treatment of advanced soft-tissue sarcomas (STSs) in combination with doxorubicin, based on the results of the Phase Ib/II trial by Tap et al...
2018: OncoTargets and Therapy
Jeong-Won Lee, Jeong-Yeol Park, Hyun Ju Lee, Jong Jin Lee, Seung Hwan Moon, Seo Young Kang, Gi Jeong Cheon, Hyun Hoon Chung
PURPOSE: We investigated the prognostic value of the tumour heterogeneity index determined on preoperative [18 F]FDG PET/CT in patients with uterine leiomyosarcoma (LMS). METHODS: We retrospectively reviewed patients with uterine LMS who underwent preoperative [18 F]FDG PET/CT scans at three tertiary referral hospitals. The PET/CT parameters maximum standardized uptake value of the primary tumour (SUVmax ), metabolic tumour volume (MTV) and total lesion glycolysis were assessed...
February 28, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Rahel A Kubik-Huch, Michael Weston, Stephanie Nougaret, Henrik Leonhardt, Isabelle Thomassin-Naggara, Mariana Horta, Teresa Margarida Cunha, Cristina Maciel, Andrea Rockall, Rosemarie Forstner
OBJECTIVE: The aim of the Female Pelvic Imaging Working Group of the European Society of Urogenital Radiology (ESUR) was to develop imaging guidelines for MR work-up in patients with known or suspected uterine leiomyomas. METHODS: Guidelines for imaging uterine leiomyomas were defined based on a survey distributed to all members of the working group, an expert consensus meeting at European Congress of Radiology (ECR) 2017 and a critical review of the literature...
February 28, 2018: European Radiology
Matthias B Stope, Victor Cernat, Anne Kaul, Karoline Diesing, Dominique Koensgen, Martin Burchardt, Alexander Mustea
BACKGROUND/AIM: Uterine leiomyosarcoma (uLMS) is a very rare mesenchymal tumor showing an aggressive clinical course and poor prognosis for patients. Due to the low incidence, little is known about molecular tumor biology and biomarkers of uLMS. Micro-RNA-1 (miR-1) has been identified as a pivotal tumor suppressor in numerous entities being suited as a molecular marker for tumor progression. MATERIALS AND METHODS: uLMS patient samples were analyzed regarding their miR-1 expression levels...
March 2018: Anticancer Research
Nilgün Yilmaz Demirci, Nurgül Naurzvai, Ismail Kirbaş, Nalan Akyürek, Gül Gürsel, Can Öztürk
Leiomyosarcomas are rare neoplasms of the smooth muscles. Primary pulmonary leiomyosarcomas, which constitute approximately 0.2%-0.5% of all primary lung malignancies, are extremely rare and highly lethal. They may originate from the smooth muscle cells of the bronchial wall, the blood vessels, or the pulmonary interstitium, and their rare occurrence, localization, and nonspecific clinical symptoms mean that correct diagnosis and proper management are often delayed. Here, we report a rapidly growing primary pulmonary leiomyosarcoma, which invaded the right atrium, vena cava superior, mediastinum, right hilar area, and left pulmonary artery within 4 months...
March 2018: Lung India: Official Organ of Indian Chest Society
Angela C Hirbe, Jack Jennings, Nael Saad, Joseph D Giardina, Yu Tao, Jingqin Luo, Shellie Berry, Jacqui Toeniskoetter, Brian A Van Tine
LESSONS LEARNED: Ablation therapy appears to be a reasonably safe and effective approach to obtain a significant treatment-free interval for a subset of patients with limited sites of metastatic disease for which systemic control can be obtained with six cycles of chemotherapy. BACKGROUND: Metastatic sarcoma often becomes resistant to treatment by chemotherapy. There is sometimes prolonged stable disease from active chemotherapy that provides a window of opportunity for an intervention to prolong disease-free survival...
February 27, 2018: Oncologist
Kerry Thomas, Philippe Spiess, Jamie T Caracciolo
Penile cancer is an uncommon primary genitourinary malignancy, the vast majority representing superficial squamous cell carcinomas. However, less common skin cancers, secondary malignancies, mesenchymal neoplasms, and hematopoietic tumors do affect the penis. Medical history, atypical presentation, and deep epicenter of a penile mass may raise question of a nonepithelial neoplasm. We describe and discuss 2 examples of rare deep-seated penile malignancies, leiomyosarcoma and B-cell lymphoma.
December 2017: Radiology Case Reports
Andrzej Woźniak, Sławomir Woźniak
Uterine leiomyomas or uterine fibroids are the most common gynaecological tumours and occur in about 20-50% of women around the world. Ultrasonography (USG) is the first-line imaging examination in suspected fibroids and shows high sensitivity and specificity in diagnosing this condition. Ultrasound scans can be performed transvaginally (transvaginal scan - TVS) or transabdominally (transabdominal scan - TAS); both scans have advantages and limitations, but, in general, transvaginal sonography is superior to transabdominal sonography in most cases of pelvic pathology...
December 2017: Przeglad Menopauzalny, Menopause Review
Kosei Hasegawa
No abstract text is available yet for this article.
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jing Li, Pan Liang, Dandan Zhang, Jie Liu, Hongkai Zhang, Jinrong Qu, Jianbo Gao
BACKGROUND: Carcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of imaging features. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinicopathologic and imaging features of six cases of hepatic carcinosarcoma (HCS) confirmed by surgical pathologic evaluation. METHODS: We retrospectively studied the clinicopathologic and imaging features of six cases of HCS (matching the World Health Organization definition) and discussed the differential diagnosis on the basis of imaging findings...
February 27, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Valentina Sangiorgio, Vanna Zanagnolo, Giovanni Aletti, Luca Bocciolone, Simone Bruni, Fabio Landoni, Nicoletta Colombo, Angelo Maggioni, Enzo Ricciardi
Cervical sarcomas are rare neoplasms, accounting for <1% of all cervical malignancies and characterized by an aggressive course despite radical excision. We report the clinical and microscopic features of a spindle cell sarcoma arising as a polypoid endocervical mass in a 45-yr-old woman. The neoplasm was characterized by a monotonous, mildly atypical proliferation of spindle cells, displaying a fibrosarcoma-like parallel pattern of highly dense fascicles, growing under the cervical epithelium. Mitotic activity was conspicuous, with up to 40 mitoses per 10 HPF...
February 22, 2018: International Journal of Gynecological Pathology
Can Yin, Anqiang Yang, Ying Zhang, Lin Tao, Hong Zou, Yan Ren, Weihua Liang, Jinfang Jiang, Jin Zhao, Wenjie Zhang, Feng Li, Wei Jia
Primary cervical malignant melanoma (MM) is an extremely rare tumor, and we are only aware of 44 reported cases. Further information is needed with regard to this disease's clinicopathologic features. Two patients (55 and 81 yr old) with postmenopausal vaginal bleeding were diagnosed with primary cervical MM on the basis of hematoxylin-eosin staining and immunohistochemistry findings. Our literature review revealed that the average age in cases of primary cervical MM was 59 yr (range, 34-81 yr); 93% of patients presented with vaginal bleeding, and 82% of patients were diagnosed at an early clinical stage (International Federation of Gynecology and Obstetrics stages I-II)...
February 22, 2018: International Journal of Gynecological Pathology
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