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Isabelle Ray-Coquard, Delphine Serre, Peter Reichardt, Javier Martín-Broto, Sebastian Bauer
Management of soft tissue sarcoma is increasingly subtype-dependent. Surgery is recommended for uterine leiomyosarcoma, with trabectedin being the preferred option for advanced disease when the treatment goal is long-term tumor stabilization. Liposarcoma subgroups are characterized by distinctive morphologies and genetics, different patterns of disease progression and clinical behavior, and variable responses to treatment. Genetic analysis of sarcomas has provided insights into pathogenesis with potential for developing new molecular targets...
May 2018: Future Oncology
Giorgio Bogani, Antonino Ditto, Fabio Martineli, Mauro Signorelli, Valentina Chiappa, Caterina Fonatella, Roberta Sanfilippo, Umberto Leone Roberti Maggiore, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
In the recent years, angiogenetic inhibitors have emerged for the treatment of several malignancies. In particular, bevacizumab has proved to be effective in many types of cancers (including sarcoma), but the limitations of antiangiogenic therapy have been shown in practice. Here, we sought to review the current evidence on the role and efficacy of bevacizumab in patients affected by uterine leiomyosarcoma. On April 2017, Literature was searched in order to identify studies reporting outcomes of patients affected either by early stage or advanced/recurred uterine leiomyosarcoma undergoing treatment with bevacizumab, alone or in combination with other chemotherapeutic regimens...
June 2018: Critical Reviews in Oncology/hematology
Koichi Torihashi, Chin Masaki, Kazumichi Yoshida, Osamu Narumi, Sen Yamagata
BACKGROUND: Primary intracranial leiomyosarcoma is a very rare occurrence. And primary leiomyosarcoma with intra-tumoral hemorrhage has not been published. We firstly present a case report of a rapidly enlarging primary intracranial leiomyosarcoma with intra-tumoral hemorrhage. CASE DESCRIPTION: A 41-yr old female presented with right hemiparesis and gait disturbance. And she has the brain tumor on frontal lobe. And the tumor was increasing rapidly. Intra-tumoral hemorrhage was suddenly occurred...
May 10, 2018: World Neurosurgery
Umesh Jayarajah, Manoj Hilary Fernando, Kasun Bandara Herath, Vipula Chandu de Silva, Serozsha Anura Sahadeva Goonewardena
Partial cystectomy with wide local excision may be considered a suitable option for selective cases of locally advanced bladder leiomyosarcoma without evidence of distant metastasis; thereby preserving the functional outcome and quality of life. A negative margin, complete tumor resection, and frequent follow-up in such patients are mandatory.
May 2018: Clinical Case Reports
Rohan C Parikh, Maria Lorenzo, Lisa M Hess, Sean D Candrilli, Steven Nicol, James A Kaye
Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes. Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011...
2018: Clinical Sarcoma Research
Vijaya Kumar Jayaram, J Parikshith, Geeta Sowmya Narayanan, Richa Tiwari, R Veena, S Prathima, M S Ganesh, Chattakonda Sai Snehith, Esther Praisy
We present the case of a young female patient who presented to the outpatient department with a history of bleeding per vagina, diagnosed with leiomyosarcoma of the cervix; the patient underwent total abdominal hysterectomy with pelvic lymph node dissection. In this article, we mainly discuss multimodality therapy in the management of an unusual variety of tumour in the uterine cervix.
2018: Ecancermedicalscience
Ana Ortins-Pina, Luís Soares-de-Almeida, Arno Rütten
Primary smooth muscle malignancies in the skin account for approximately 2-3% of all soft tissue sarcomas1,2 . We read with interest a recent JCP report on a vascular leiomyosarcoma arising from vena saphena magna3 . We report herein a case of primary cutaneous vascular leiomyosarcoma arising from a small-caliber dermal vein.
May 8, 2018: Journal of Cutaneous Pathology
C Ma, P Y Li, N Zhang, C B Sun, L Hou, N Liu
Objective: To investigate the expression and prognostic value of alpha smooth muscle actin(α-SMA) and Ki-67 in retroperitoneal leiomyosarcoma. Methods: Fifty retroperitoneal leiomyosarcoma patients who underwent operation in Chinese People's Liberation Army General Hospital from May 2002 to December 2015 were retrospectively analyzed. There were 14 males and 36 females form 21 to 79 and an average age of 48. Kaplan-Meier estimations and Cox regression analyses were performed. Results: Of the 50 cases, 45 patients underwent complete resection, and others are not...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Mervat M Soltan, Abdelkader Mohammed Albasry, Maha K Eldosouky, Hanan S Abdelhamid
Uterine smooth muscle tumors constitute a spectrum of neoplasms. Diagnosis of leiomyomas (LMs) is usually straight forwards; however, atypical leiomyomas (ALMs) and smooth muscle tumors of uncertain malignant potential (STUMPs) have overlapping features and need to be distinguished from leiomyosarcoma. To evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R), and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcomas and to assess their possible role in differentiating those tumors...
April 30, 2018: Cellular and Molecular Biology
Kathryn E Engelhardt, Malcolm M DeCamp, Anthony D Yang, Karl Y Bilimoria, David D Odell
BACKGROUND: Primary mediastinal sarcomas are rare and deadly. Our objective was to describe the clinicopathological features, treatment strategies, and overall survival outcomes for a contemporary cohort of patients diagnosed with primary mediastinal sarcoma in the United States. METHODS: We queried the National Cancer Database for cases of mediastinal sarcoma diagnosed from 2004-2012. Five-year overall survival (OS) was examined using the Kaplan-Meier method. Differences in OS were assessed using log-rank analysis and Cox proportional hazards regression...
May 2, 2018: Annals of Thoracic Surgery
Xiaolei Ren, Chao Tu, Zhenchu Tang, Ruofei Ma, Zhihong Li
Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently associated with α-thalassemia syndrome. Cancer cells depend on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative programmed mortality...
May 2018: Oncology Letters
Matthew D Miller, Daniel Y Sze, Siddharth A Padia, Robert J Lewandowski, Riad Salem, Philani Mpofu, Paul M Haste, Matthew S Johnson
PURPOSE: To evaluate the effectiveness and safety of yttrium-90 transarterial radioembolization (TARE) for the treatment of primary and metastatic soft tissue sarcoma (STS) of the liver. MATERIALS AND METHODS: A retrospective review of 39 patients with primary (n = 2) and metastatic (n = 37) hepatic STS treated with TARE at 4 institutions was performed. Fourteen STS subtypes were included, with leiomyosarcoma being the most common (51%). TARE with glass (22 patients) or resin (17 patients) microspheres was performed, with single lobe (17 patients) or bilobar treatment (22 patients) based on disease burden...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
Nathalia Dias Negrão Murback, Luiz C Takita, Bruna Corrêa de Castro, Gunter Hans Filho
Leiomyosarcoma is a rare skin tumor, most common in white men in the fifth to eighth decades of life. Primary tumors are classified in dermal or subcutaneous, that differ by clinical and prognostic features. They may appear on any site of the body, but are rare on the face. A 54-year-old female was admitted with a 5cm exophytic nodular lesion of 8 months duration on the right cheek, site of previous chronic radiodermatitis. Histopathology revealed spindle-shaped cell neoplasia, positive for smooth muscle actin on immunohistochemistry...
March 2018: Anais Brasileiros de Dermatologia
Cynthia De Carvalho Fischer, Yue Hu, Michael Morreale, Wan Ying Lin, Akhil Wali, Maya Thakar, Enusha Karunasena, Rupashree Sen, Yi Cai, Lauren Murphy, Cynthia A Zahnow, Harold Keer, Manjusha Thakar, Nita Ahuja
Leiomyosarcomas are rare mesenchymal neoplasms characterized by a smooth muscle differentiation pattern. Due to the extremely poor prognosis in patients, the development of novel chemotherapeutic regimens remains critically important. In this study, multiple leiomyosarcoma cell lines, SK-UT1, SK-LMS1, and MES-SA were treated with varying doses of the DNA Methyltransferase Inhibitors (DNMTi) 5-azacitidine (Aza), 5-aza-2-deoxycytidine (DAC), and guadecitabine (SGI-110). The effect of these epigenetic modulators was measured using both in-vitro and in-vivo models...
April 10, 2018: Oncotarget
Arun Ramdas Menon, Rajeev Thekke Puthalath, Nivedita Suresh, Suraj Hegde
Leiomyosarcomas (LMSs) account for <0.1% of all bladder malignancies. Due to the infrequent occurrence of these tumors, established guidelines for management are lacking. Conventionally, radical extirpative surgery has been advocated. We present our experience with organ preservation in a young male presenting with LMS bladder. A brief review of literature supporting organ preservation in selected cases has also been presented.
April 2018: Urology Annals
Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Eiichi Konishi, Toshikazu Kubo
INTRODUCTION: Leiomyosarcoma is a highly malignant soft tissue sarcoma. Most leiomyosarcomas of the extremities metastasize initially to the lungs, with few metastasizing to the liver. Also, it is difficult to diagnose metastases to other regions of the lung during follow-up. CASE PRESENTATION: The first patient was a 51-year-old Japanese woman diagnosed with a leiomyosarcoma of the left distal femur. She underwent chemotherapy, followed by wide tumor excision and reconstruction using frozen autograft with total knee arthroplasty...
May 2018: Medicine (Baltimore)
Keisuke Fukui, Nobuhisa Takase, Taiichiro Miyake, Koji Hisano, Eri Maeda, Tohru Nishimura, Koichiro Abe, Akihito Kozuki, Tomohiro Tanaka, Naoki Harada, Manabu Takamatsu, Kunihiko Kaneda
Metastatic hepatic leiomyosarcoma is a rare malignant smooth muscle tumor. We report a case of metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential (STUMP). A 68-year-old female presented with a liver mass (60 mm × 40 mm, Segment 4). She underwent left salpingo-oophorectomy for an ovary tumor with STUMP in a broad ligament 6 years ago. Though FDG-PET showed obvious metabolically active foci, abnormal metabolically active foci other than the lesion were not detected...
April 27, 2018: World Journal of Hepatology
Melissa Amberger, Timothy Park, Bert Petersen, Gerard A Baltazar
INTRODUCTION: Primary leiomyosarcomas of the breast are extremely rare. Because of this rarity, only a small number of studies have been published about the disease; diagnosis, treatment, and prognosis are not well-described. Our work has been reported in line with the SCARE criteria. PRESENTATION OF CASE: We present a 20-year-old female with primary breast leiomyosarcoma who despite mastectomy, developed lung metastases three years later. DISCUSSION: We discuss the rarity of breast leiomyosarcoma and risk of metastatic disease even with treatment...
April 16, 2018: International Journal of Surgery Case Reports
Di You, Qilin Wang, Wei Jiang, Lin Lin, Tianjin Yi, Lingjun Zhao, Maomao Li, Ping Wang
RATIONALE: Primary leiomyosarcoma (LMS) of the fallopian tube is extremely uncommon. To the best of our knowledge, so far only 21 cases of primary fallopian tube LMS have been reported in English-language literature. No new case has been reported in the past 7 years. PATIENT CONCERNS: A 44-year-old premenopausal patient presented with a 5-day history of lower abdominal pain. DIAGNOSES: Pelvic ultrasonography detected an 8.8 × 7.8 × 6...
April 2018: Medicine (Baltimore)
Cecilia L Dalle Ore, Christopher P Ames, Stephen T Magill, Vedat Deviren, Manish K Aghi, Darryl Lau
INTRODUCTION: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncological outcomes of malignant spinal tumor patients who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy. METHODS: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Complications, tumor recurrence, and survival were reviewed...
April 24, 2018: World Neurosurgery
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