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https://www.readbyqxmd.com/read/28650240/development-of-a-clinical-spasticity-scale-for-evaluation-of-dogs-with-chronic-thoracolumbar-spinal-cord-injury
#1
Melissa J Lewis, Natasha J Olby
OBJECTIVE To develop a spasticity scale for dogs with chronic deficits following severe spinal cord injury (SCI) for use in clinical assessment and outcome measurement in clinical trials. ANIMALS 20 chronically paralyzed dogs with a persistent lack of hind limb pain perception caused by an acute SCI at least 3 months previously. PROCEDURES Spasticity was assessed in both hind limbs via tests of muscle tone, clonus, and flexor and extensor spasms adapted from human scales. Measurement of patellar clonus duration and flexor spasm duration and degree was feasible...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28647869/muscular-viscoelastic-characteristics-of-athletes-participating-in-the-european-master-indoor-athletics-championship
#2
Marco Gervasi, Davide Sisti, Stefano Amatori, Marco Andreazza, Piero Benelli, Piero Sestili, Marco Bruno Luigi Rocchi, Anna Rita Calavalle
PURPOSE: To investigate how the viscoelastic characteristics of muscles (non-neural tone, elasticity and stiffness) vary as a function of age and gender in a sample of track and field master athletes. To compare these findings with data on related sedentary subjects in literature. METHODS: A total of 390 athletes (aged 35-99) were assessed during the European Master Athletics Indoor Championship 2016. A non-invasive measurement device called MyotonPro was used to measure tone, stiffness, and elasticity in the biceps brachii and rectus femoris muscles at rest...
June 24, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28638932/-treatment-of-recurrent-laryngeal-nerve-paralysis
#3
A H Müller
Whereas static vocal fold medialization or lateralization are currently the standard procedures, new dynamic treatment methods such as reinnervation and laryngeal pacing focus on better toning and remobilization of the paralyzed vocal folds. End-to-end or jump anastomoses of the recurrent laryngeal nerve can preserve muscle mass and avoid atrophy, thus enabling subsequent dynamic therapeutic options. Prognostic evaluation and the time point of therapeutic intervention are important issues in the management of patients with recurrent laryngeal nerve paralysis...
June 20, 2017: HNO
https://www.readbyqxmd.com/read/28635954/phenotypic-extremes-of-bicd2-opathies-from-lethal-congenital-muscular-atrophy-with-arthrogryposis-to-asymptomatic-with-subclinical-features
#4
Markus Storbeck, Beate Horsberg Eriksen, Andreas Unger, Irmgard Hölker, Ingvild Aukrust, Lilian A Martínez-Carrera, Wolfgang A Linke, Andreas Ferbert, Raoul Heller, Matthias Vorgerd, Gunnar Houge, Brunhilde Wirth
Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2). The disease is usually characterized by a benign or slowly progressive, congenital or early onset muscle weakness and atrophy that mainly affects the lower extremities, although some affected individuals show involvement of the arms and the shoulder girdle. Here we report unusual extremes of BICD2-related diseases: A severe form of congenital muscular atrophy with arthrogryposis multiplex, respiratory insufficiency and lethality within four months...
June 21, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28629415/kaps-kinematic-assessment-of-passive-stretch-a-tool-to-assess-elbow-flexor-and-extensor-spasticity-after-stroke-using-a-robotic-exoskeleton
#5
Andrew Centen, Catherine R Lowrey, Stephen H Scott, Ting-Ting Yeh, George Mochizuki
BACKGROUND: Spasticity is a common sequela of stroke. Traditional assessment methods include relatively coarse scales that may not capture all characteristics of elevated muscle tone. Thus, the aim of this study was to develop a tool to quantitatively assess post-stroke spasticity in the upper extremity. METHODS: Ninety-six healthy individuals and 46 individuals with stroke participated in this study. The kinematic assessment of passive stretch (KAPS) protocol consisted of passive elbow stretch in flexion and extension across an 80° range in 5 movement durations...
June 19, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28626302/the-immediate-effect-of-diaphragm-taping-with-breathing-exercise-on-muscle-tone-and-stiffness-of-respiratory-muscles-and-spo2-in-stroke-patient
#6
Joong-San Wang, Kyun-Hee Cho, Shin-Jun Park
[Purpose] This study aimed to examine the immediate effects of diaphragm taping with breathing exercise on the tone and stiffness in the respiratory muscles of patient with stroke. [Subjects and Methods] A total of 28 subjects, 14 in the diaphragm taping with breathing exercise group and 14 in the breathing exercise group, were administered respective intervention methods. Subsequently, the muscle tone and stiffness in upper trapezius, scalene, external oblique abdominal and ractus abdominis muscle of both the respiratory muscles were measured...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28626301/effect-of-neurodevelopmental-treatment-based-physical-therapy-on-the-change-of-muscle-strength-spasticity-and-gross-motor-function-in-children-with-spastic-cerebral-palsy
#7
Eun-Young Park, Won-Ho Kim
[Purpose] This study aimed to investigate the effectiveness of neurodevelopmental treatment-based physical therapy on muscle tone, strength, and gross motor function in children with spastic cerebral palsy. [Subjects and Methods] One-hundred-seventy-five children with spastic cerebral palsy (88 diplegia; 78 quadriplegia) received neurodevelopmental treatment-based physical therapy for 35 minutes per day, 2-3 times per week for 1 year. Spasticity, muscle strength, and gross motor function were measured before and after treatment with the Modified Ashworth Scale, Manual Muscle Testing, and Gross Motor Function Measure, respectively...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28625735/analgesic-and-physiological-effect-of-electroacupuncture-combined-with-epidural-lidocaine-in-goats
#8
Lu-Ying Cui, Ni-Ni Guo, Yu-Lin Li, Meng Li, Ming-Xing Ding
OBJECTIVE: To investigate physiological and antinociceptive effects of electroacupuncture (EA) with lidocaine epidural nerve block in goats. STUDY DESIGN: Prospective experimental trial. ANIMALS: Forty-eight hybrid male goats weighing 27 ± 2 kg. METHODS: The goats were randomly assigned to six groups: L2.2, epidural lidocaine (2.2 mg kg(-1)); L4.4, epidural lidocaine (4.4 mg kg(-1)); EA; EA-L1.1, EA with epidural lidocaine (1...
January 12, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28625615/efficacy-and-safety-of-abobotulinumtoxina-dysport%C3%A2-for-the-treatment-of-hemiparesis-in-adults-with-upper-limb-spasticity-previously-treated-with-botulinum-toxin-sub-analysis-from-a-phase-3-randomized-controlled-trial
#9
Christina Marciniak, Peter McAllister, Heather Walker, Allison Brashear, Steven Edgley, Thierry Deltombe, Svetlana Khatkova, Marta Banach, Fatma Gul, Claire Vilain, Philippe Picaut, Anne-Sophie Grandoulier, Jean-Michel Gracies
OBJECTIVE: To assess the efficacy and safety of abobotulinumtoxinA in adults with upper limb spasticity previously treated with botulinum toxin A (BoNT-A). DESIGN: A post-hoc analysis from a Phase 3, prospective, double-blind, randomized, placebo-controlled study SETTING: 34 neurology or rehabilitation clinics in nine countries. PARTICIPANTS: Adults aged 18-80 years with hemiparesis, ≥6 months after stroke or traumatic brain injury. This analysis focused on a subgroup of subjects with previous onabotulinumtoxinA or incobotulinumtoxinA treatment (n=105 of 243 in the total trial population) in the affected limb...
June 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28623614/abobotulinumtoxina-a-review-in-pediatric-lower-limb-spasticity
#10
Yahiya Y Syed
AbobotulinumtoxinA (Dysport(®)) is currently the only botulinum toxin A formulation approved by the US FDA for the treatment of lower limb spasticity in pediatric patients aged ≥2 years. Intramuscular abobotulinumtoxinA was approved based on the results of a pivotal phase 3 trial in children with lower limb spasticity due to cerebral palsy. In this trial, a single treatment cycle with abobotulinumtoxinA 10-15 U/kg/leg injected into the gastrocnemius and soleus muscles significantly improved ankle plantar flexor muscle tone (primary endpoint), with abobotulinumtoxinA recipients showing a significant response to treatment relative to placebo...
June 16, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28619175/sodium-oxybate-treatment-in-narcolepsy-and-its-effect-on-muscle-tone
#11
Geert Mayer, Andrea Rodenbeck, Karl Kesper
AIMS: To estimate the effect of the compound sodium oxybate (SO) on chin muscle tone in sleep, a re-analysis of the results of the international multicenter study SXB-15 was performed, applying a validated semi-automatic analysis of muscle tone. This analysis distinguishes short (<0.5 s) and long (>0.5 s) muscle activity indices per hour (SMI, LMI) in 116 patients with narcolepsy-cataplexy. While stable stimulant medication was permitted, tricyclics and SSRIs were withdrawn. Polysomnographies were performed at baseline (V5), four weeks after titration of SO to 4...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28615966/acute-physiological-and-electrical-accentuation-of-vagal-tone-has-no-effect-on-pain-or-gastrointestinal-motility-in-chronic-pancreatitis
#12
Jacob Juel, Christina Brock, Søren S Olesen, Adnan Madzak, Adam D Farmer, Qasim Aziz, Jens B Frøkjær, Asbjørn Mohr Drewes
BACKGROUND: The effective management of pain in chronic pancreatitis (CP) remains a therapeutic challenge. Analgesic drugs, such as opioids, and the underlying pathology can impair gut function. The autonomic nervous system influences hormone secretion and gut motility. In healthy volunteers, electrical (using noninvasive transcutaneous vagal nerve stimulation [t-VNS]) and physiological (using deep slow breathing [DSB]) modulation of parasympathetic tone results in pain attenuation and enhanced gut motility...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28603637/t-type-voltage-gated-ca-2-channels-do-not-contribute-to-the-negative-feedback-regulation-of-myogenic-tone-in-murine-superior-epigastric-arteries
#13
Brendan Mullan, Jessica Pettis, William F Jackson
T-type voltage-gated Ca(2+) channels (CaV3.2 VGCC) have been hypothesized to control spontaneous transient outward currents (STOCs) through large-conductance Ca(2+)-activated K(+) channels (BKCa), and contribute to the negative-feedback regulation of myogenic tone. We tested this hypothesis in superior epigastric arteries (SEAs) isolated from male C57BL/6 mice. SEAs were isolated and enzymatically dissociated to obtain single smooth muscle cells (SMCs) for whole-cell recording of paxilline-sensitive (PAX, 1 μmol/L) STOCs at -30 mV, or cannulated and studied by pressure myography (80 cm H2O, 37°C)...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28603362/comparison-of-muscular-fatigue-and-tone-of-neck-according-to-craniocervical-flexion-exercise-and-suboccipital-relaxation-in-cervicogenic-headache-patients
#14
Dae Jung Yang, Da Haeng Kang
[Purpose] This study was conducted to compare and analyze influence of craniocervical flexion and suboccipitalis relaxation in cervicogenic headache patients of their cervical muscular fatigue, tone, and headache intensity. [Subjects and Methods] 30 patients with cervicogenic headache were selected and 10 subjects per group were randomly assigned to control group, craniocervical flexion exercise group, and suboccipitalis relaxation group. Intervention for each group was provided 5 times a week for 4 weeks. Muscular tone test and muscular fatigue test were conducted on both sides of upper trapezius and sternocleidomastoideus and visual analogue sclae on the headache intensity was conducted before the intervention, after 2 weeks, and after 4 weeks...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28601540/atrial-fibrilation-in-anaphylaxis
#15
Patricia Rojas-Perez-Ezquerra, Blanca Noguerado-Mellado, Cristina Morales-Cabeza, Gabriela Zambrano Ibarra, Tomas Datino Romaniega
BACKGROUND: The relationship between anaphylaxis and cardiovascular events has been reported in the past. While skin and respiratory symptoms are usually the most common and the first to appear, cardiovascular complications play a key role and represent the leading cause of death in anaphylaxis. METHODS: We report 3 episodes of atrial fibrillation triggered by anaphylaxis. Allergy and cardiology studies were performed. In both patients, the etiological agent was identified: Anisakis simplex hypersensitivity and food allergy...
June 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28596945/treatment-with-pcramoll-alone-and-in-combination-with-fluconazole-provides-therapeutic-benefits-in-c-gattii-infected-mice
#16
Jannyson J Jandú, Marliete C Costa, Julliana R A Santos, Fernanda M Andrade, Thais F Magalhães, Márcia V Silva, Maria C A B Castro, Luanna C B B Coelho, Aline G Gomes, Tatiane A Paixão, Daniel A Santos, Maria T S Correia
Cryptococcus gattii is one of the main causative agents of cryptococcosis in immunocompetent individuals. Treatment of the infection is based on the use of antimycotics, however, the toxicity of these drugs and the increase of drug-resistant strains have driven the search for more effective and less toxic therapies for cryptococcosis. pCramoll are isolectins purified from seeds of Cratylia mollis, a native forage plant from Brazil, which has become a versatile tool for biomedical application. We evaluated the effect of pCramoll alone and in combination with fluconazole for the treatment of mice infected with C...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28590525/effects-of-repeated-abobotulinumtoxina-injections-in-upper-limb-spasticity
#17
Jean-Michel Gracies, Michael O'Dell, Michele Vecchio, Peter Hedera, Serdar Kocer, Monika Rudzinska-Bar, Bruce Rubin, Sofiya L Timerbaeva, Anna Lusakowska, François Constant Boyer, Anne-Sophie Grandoulier, Claire Vilain, Philippe Picaut
INTRODUCTION: The efficacy of single injections of abobotulinumtoxinA (Dysport®) is established in adults with upper limb spasticity. This study aimed to assess the effects of repeated injections of abobotulinumtoxinA over 1 year. METHODS: Patients (n=258 safety population) received 500U, 1000U or 1500U (1500U dose included 500U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA ), angle of catch (XV3 ), Disability Assessment Scale (DAS), Modified Frenchay Scale (MFS) and Physician Global Assessment (PGA)...
June 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28588038/the-amp-related-kinase-ampk-induces-ca-2-independent-dilation-of-resistance-arteries-by-interfering-with-actin-filament-formation
#18
Kai M Schubert, Jiehua Qiu, Stephanie Blodow, Margarethe Wiedenmann, Lubomir T Lubomirov, Gabriele Pfitzer, Ulrich Pohl, Holger Schneider
Rationale: Decreasing Ca(2+) sensitivity of vascular smooth muscle (VSM) allows for vasodilation without lowering of cytosolic Ca(2+) This may be particularly important in states requiring maintained dilation such as hypoxia. AMPK is an important cellular energy sensor in VSM. Regulation of Ca(2+) sensitivity usually is attributed to myosin light chain phosphatase (MLCP) activity but findings in non-VSM identified changes in the actin cytoskeleton. The potential role of AMPK in this setting is widely unknown...
June 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28582916/the-force-control-and-path-planning-of-electromagnetic-induction-based-massage-robot
#19
Wendong Wang, Lei Zhang, Qinqin Jiang, Lijing He, Yikai Shi
BACKGROUND: Massage robot is considered as an effective physiological treatment to relieve fatigue, improve blood circulation, relax muscle tone, etc. The simple massage equipment quickly spread into market due to low cost, but they are not widely accepted due to restricted massage function. Complicated structure and high cost caused difficulties for developing multi-function massage equipment. OBJECTIVE: This paper presents a novel massage robot which can achieve tapping, rolling, kneading and other massage operations, and proposes an improved reciprocating path planning algorithm to improve massage effect...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28580075/role-of-vasopressin-in-current-anesthetic-practice
#20
REVIEW
Keun Suk Park, Kyung Yeon Yoo
Arginine vasopressin (AVP), also known as antidiuretic hormone, is a peptide endogenously secreted by the posterior pituitary in response to hyperosmolar plasma or systemic hypoperfusion states. When administered intravenously, it causes an intense peripheral vasoconstriction through stimulation of V1 receptors on the vascular smooth muscle. Patients in refractory shock associated with severe sepsis, cardiogenic or vasodilatory shock, or cardiopulmonary bypass have inappropriately low plasma levels of AVP ('relative vasopressin deficiency') and supersensitivity to exogenously-administered AVP...
June 2017: Korean Journal of Anesthesiology
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