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Bayley scales

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https://www.readbyqxmd.com/read/28931055/serum-copeptin-and-neuron-specific-enolase-are-markers-of-neonatal-distress-and-long-term-neurodevelopmental-outcome
#1
Dorottya Kelen, Csilla Andorka, Miklós Szabó, Aleksander Alafuzoff, Kai Kaila, Milla Summanen
The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48, 72, and 168 hours after birth from 75 term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia for 72 hours...
2017: PloS One
https://www.readbyqxmd.com/read/28928195/reach-study-protocol-of-a-randomised-trial-of-rehabilitation-very-early-in-congenital-hemiplegia
#2
Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Iona Novak, Nadia Badawi, Kerstin Pannek, Catherine Elliott, Susan Greaves, Andrea Guzzetta, Koa Whittingham, Jane Valentine, Cathy Morgan, Margaret Wallen, Ann-Christin Eliasson, Lisa Findlay, Robert Ware, Simona Fiori, Stephen Rose
OBJECTIVES: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28925580/nutrition-hygiene-and-stimulation-education-to-improve-growth-cognitive-language-and-motor-development-among-infants-in-uganda-a-cluster-randomized-trial
#3
Grace K M Muhoozi, Prudence Atukunda, Lien M Diep, Robert Mwadime, Archileo N Kaaya, Anne B Skaare, Tiril Willumsen, Ane C Westerberg, Per O Iversen
Stunting is associated with impaired cognitive and motor function. The effect of an education intervention including nutrition, stimulation, sanitation, and hygiene on child growth and cognitive/language/motor development, delivered to impoverished mothers in Uganda, was assessed. In a community-based, open cluster-randomized trial, 511 mother/children dyads aged 6-8 months were enrolled to an intervention (n = 263) or control (n = 248) group. The primary outcome was change in length-for-age z-score at age 20-24 months...
September 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28924555/early-changes-in-brain-structure-correlate-with-language-outcomes-in-children-with-neonatal-encephalopathy
#4
Kevin A Shapiro, Hosung Kim, Maria Luisa Mandelli, Elizabeth E Rogers, Dawn Gano, Donna M Ferriero, A James Barkovich, Maria Luisa Gorno-Tempini, Hannah C Glass, Duan Xu
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28912368/neurodevelopment-of-hiv-exposed-and-hiv-unexposed-uninfected-children-at-24-months
#5
Sumona Chaudhury, Paige L Williams, Gloria K Mayondi, Jean Leidner, Penny Holding, Vicki Tepper, Sharon Nichols, Jane Magetse, Maureen Sakoi, Kebaiphe Moabi, Joseph Makhema, Charlotte Mdluli, Haruna Jibril, George R Seage, Betsy Kammerer, Shahin Lockman
BACKGROUND: We sought to determine if HIV-exposed uninfected (HEU) children had worse neurodevelopmental outcomes at 24 months compared with HIV-unexposed uninfected (HUU) children in Botswana. METHODS: HIV-infected and uninfected mothers enrolled in a prospective observational study ("Tshipidi") in Botswana from May 2010 to July 2012. Child neurodevelopment was assessed at 24 months with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III: cognitive, gross motor, fine motor, expressive language, and receptive language domains) and the Development Milestones Checklist (DMC), a caregiver-completed questionnaire (locomotor, fine motor, language and personal-social domains)...
September 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/28901887/microcytosis-is-associated-with-low-cognitive-outcomes-in-healthy-2-year-olds-in-a-high-resource-setting
#6
Elaine K McCarthy, Mairead E Kiely, Geraldine Hannon, Caroline Ahearne, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case-control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28893979/exposure-to-unpredictable-maternal-sensory-signals-influences-cognitive-development-across-species
#7
Elysia Poggi Davis, Stephanie A Stout, Jenny Molet, Brian Vegetabile, Laura M Glynn, Curt A Sandman, Kevin Heins, Hal Stern, Tallie Z Baram
Maternal care is a critical determinant of child development. However, our understanding of processes and mechanisms by which maternal behavior influences the developing human brain remains limited. Animal research has illustrated that patterns of sensory information is important in shaping neural circuits during development. Here we examined the relation between degree of predictability of maternal sensory signals early in life and subsequent cognitive function in both humans (n = 128 mother/infant dyads) and rats (n = 12 dams; 28 adolescents)...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#8
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
September 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28878181/developmental-outcomes-at-24-months-of-age-in-toddlers-supplemented-with-arachidonic-acid-and-docosahexaenoic-acid-results-of-a-double-blind-randomized-controlled-trial
#9
Angela M Devlin, Cecil M Y Chau, Roger Dyer, Julie Matheson, Deanna McCarthy, Karin Yurko-Mauro, Sheila M Innis, Ruth E Grunau
Little is known about arachidonic acid (ARA) and docosahexaenoic acid (DHA) requirements in toddlers. A longitudinal, double blind, controlled trial in toddlers ( n = 133) age 13.4 ± 0.9 months (mean ± standard deviation), randomized to receive a DHA (200 mg/day) and ARA (200 mg/day) supplement (supplement) or a corn oil supplement (control) until age 24 months determined effects on neurodevelopment. We found no effect of the supplement on the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) cognitive and language composites and Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI) at age 24 months...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28866004/neurodevelopmental-outcomes-of-infants-with-very-low-birth-weights-are-associated-with-the-severity-of-their-extra-uterine-growth-retardation
#10
Han-Chun Chien, Chao-Huei Chen, Teh-Ming Wang, Ya-Chi Hsu, Ming-Chih Lin
BACKGROUND: For infants with very low birth weights (VLBW), their neurodevelopmental outcomes are thought to be associated with extra-uterine growth retardation (EUGR). In this study, based on a single institute, we analyzed the association between different levels or severity of EUGR of VLBW infants and their neurodevelopmental outcomes later at a corrected age of 24 months. METHODS: This is a hospital-based retrospective cohort study. The severity of EUGR was classified into three categories according to the z-score of discharge weight: z < -2...
August 11, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28851784/the-effects-of-vitamin-b12-supplementation-in-pregnancy-and-postpartum-on-growth-and-neurodevelopment-in-early-childhood-study-protocol-for-a-randomized-placebo-controlled-trial
#11
Ram K Chandyo, Manjeswori Ulak, Ingrid Kvestad, Merina Shrestha, Suman Ranjitkar, Sudha Basnet, Mari Hysing, Laxman Shrestha, Tor A Strand
INTRODUCTION: Vitamin B12 is crucial for normal cell division and differentiation, and necessary for the development and myelination of the central nervous system. Pregnant mothers in resource poor settings are at risk for poor vitamin B12 status. Poor vitamin B12 status in infancy is linked to poor growth and neurodevelopment. Brain development starts from conception, and pregnancy is a period of rapid growth and development for the brain. METHODS AND ANALYSIS: The study is an individually randomised double-blind placebo controlled trial in 800 pregnant Nepalese women randomised in a 1:1 ratio...
August 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28846688/effects-of-lay-support-for-pregnant-women-with-social-risk-factors-on-infant-development-and-maternal-psychological-health-at-12-months-postpartum
#12
Emma Popo, Sara Kenyon, Sophie-Anna Dann, Christine MacArthur, Jacqueline Blissett
BACKGROUND: The ELSIPS (Evaluation of Lay Support in Pregnant Women with Social Risk) RCT showed that lay support for women with social risk had a positive effect on maternal mental health and mother-infant bonding. This exploratory study examined whether these observed benefits would impact infant development at 1 year. METHODS: A sub-sample of women whose infants were under one year who had participated in the ELSIPS RCT which randomised women to receive either standard care or the services of a Pregnancy Outreach Worker (POW), and who were contactable, were eligible to participate in the follow up...
2017: PloS One
https://www.readbyqxmd.com/read/28839077/alcohol-consumption-in-a-general-antenatal-population-and-child-neurodevelopment-at-2-years
#13
Jane L Halliday, Evelyne Muggli, Sharon Lewis, Elizabeth J Elliott, David J Amor, Colleen O'Leary, Susan Donath, Della Forster, Cate Nagle, Jeffrey M Craig, Peter J Anderson
BACKGROUND: Prenatal alcohol exposure (PAE) is a community health problem with up to 50% of pregnant women drinking alcohol. The relationship between low or sporadic binge PAE and adverse child outcomes is not clear. This study examines the association between PAE in the general antenatal population and child neurodevelopment at 2 years, accounting for relevant contributing factors. METHODS: This prospective population-based cohort recruited 1570 pregnant women, providing sociodemographic, psychological and lifestyle information and alcohol use for five time periods...
August 24, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28836705/survival-and-neurodevelopmental-outcomes-in-extremely-preterm-infants-22-24%C3%A2-weeks-of-gestation-born-in-western-australia
#14
Mary Sharp, Noel French, Judy McMichael, Catherine Campbell
AIM: The management of births at borderline viability continues to present dilemmas for health professionals and parents. The aim of the study was to review local outcomes of infants born between 22 and 24 weeks of gestation between 2004 and 2010 in Western Australia (WA) to aid perinatal counselling. METHODS: Survival data for the study were sourced retrospectively from the Neonatal Clinical Care Unit and Department of Health records of births in WA. Neurodevelopmental follow-up outcomes were assessed using the most recent standardised assessment (Griffiths, Bayley-III and Wechsler Preschool and Primary Scale of Intelligence, 3rd Ed) and medical examination of infants/children 12 months to 8 years from follow-up clinic appointments...
August 24, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28835912/use-of-the-bayley-scales-of-infant-and-toddler-development-third-edition-to-assess-developmental-outcome-in-infants-and-young-children-in-an-urban-setting-in-south-africa
#15
Daynia E Ballot, Tanusha Ramdin, David Rakotsoane, Faustine Agaba, Victor A Davies, Tobias Chirwa, Peter A Cooper
BACKGROUND: The Bayley Scales of Infant and Toddler Development (III) is a tool developed in a Western setting. AIM: To evaluate the development of a group of inner city children in South Africa with no neonatal risk factors using the Bayley Scales of Infant and Toddler Development (III), to determine an appropriate cut-off to define developmental delay, and to establish variation in scores done in the same children before and after one year of age. METHODS: Cohort follow-up study...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28822941/selenium-status-during-pregnancy-influential-factors-and-effects-on-neuropsychological-development-among-spanish-infants
#16
Rubén Amorós, Mario Murcia, Ferran Ballester, Karin Broberg, Carmen Iñiguez, Marisa Rebagliato, Helena Skröder, Llúcia González, Maria-Jose Lopez-Espinosa, Sabrina Llop
Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005)...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28820348/where-to-now-avert-answered-an-important-question-but-raised-many-more
#17
Mark T Bayley, Audrey Bowen, Coralie English, Robert Teasell, Janice J Eng
A Very Early Rehabilitation Trial (AVERT) was a Phase 3 randomized trial with over 2100 subjects post stroke that had unexpected results with better outcomes for usual care than those receiving very early mobilization. This review of published stroke clinical practice guidelines highlights that recommendations for mobilization have changed after publication of AVERT but also that developers have struggled to provide recommendations for appropriate dose, duration and intensity of mobilization in the acute post stroke period with available analyses from AVERT and other literature...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28813555/analysis-of-item-level-bias-in-the-bayley-iii-language-subscales-the-validity-and-utility-of-standardized-language-assessment-in-a-multilingual-setting
#18
Shaun K Y Goh, Elaine K H Tham, Iliana Magiati, Litwee Sim, Shamini Sanmugam, Anqi Qiu, Mary L Daniel, Birit F P Broekman, Anne Rifkin-Graboi
Purpose: The purpose of this study was to improve standardized language assessments among bilingual toddlers by investigating and removing the effects of bias due to unfamiliarity with cultural norms or a distributed language system. Method: The Expressive and Receptive Bayley-III language scales were adapted for use in a multilingual country (Singapore). Differential item functioning (DIF) was applied to data from 459 two-year-olds without atypical language development...
September 18, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28804749/morphine-versus-methadone-treatment-for-neonatal-withdrawal-and-impact-on-early-infant-development
#19
Sharon Burke, Anna Malia Beckwith
Objective. Compare developmental outcomes in infants treated with morphine versus methadone. Method. Retrospective chart review of newborns identified through use of ICD-9 code for neonatal abstinence syndrome (NAS). Thirty-six infants were evaluated-17 treated with methadone and 19 treated with morphine. Assessment was completed following treatment using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III). Scores in Cognitive, Language, and Motor domains were compared. Results. Comparison of scores between morphine- and methadone-treated groups revealed differences in mean Cognitive Composite (91...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28803151/sex-specific-differences-in-effect-of-prenatal-exposure-to-dioxin-like-compounds-on-neurodevelopment-in-japanese-children-sapporo-cohort-study
#20
Sonomi Nakajima, Yasuaki Saijo, Chihiro Miyashita, Tamiko Ikeno, Seiko Sasaki, Junboku Kajiwara, Reiko Kishi
BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects...
August 10, 2017: Environmental Research
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