Cognitio

Inbred mice (C57Bl/6) display wide variability in performance on hippocampal-dependent cognitive tasks. Examination of micro-dissected dentate gyrus (DG) after cognitive testing showed a highly significant negative correlation between levels of bone morphometric protein (BMP) signaling and recognition memory. Cognitive performance decline during the aging process, and the degree of cognitive decline is strongly correlated with aging-related increases in BMP signaling. Further, cognitive performance was impaired when the BMP inhibitor, noggin, was knocked down in the DG...

Cognition is derived from the Latin 'cognitio', meaning the process of acquiring knowledge, with related meanings such as study, recognition, social connectivity and discovery. The most crucial components of cognition are the ability to learn and remember new information, and to function adequately in daily intellectual and interactive aspects of life.Maintenance of normal functional cognitive activity is vitally important in everyday activities. Conversely, cognitive decline, as normally occurs during the ageing process, is a handicap...

Sir John Vane named vascular endothelium 'the maestro of blood circulation'. Recently, 'the maestro' has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardio-vascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors, HMG CoA reductase inhibitors or beta1-Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs. It is not a simple verbal change in the nomenclature. It means that these drugs apart from their well defined mechanisms of action, as indicated in their regular names, in addition they act in an unknown mechanism at the level of vascular endothelium preventing angina, myocardial infarction and stroke...

The close linkage between empiric knowledge and its magic religious background in the archaic period appears clearly as a main feature characterizing the medical ars at its beginning, at least till it advances to a full secular approach during the fifth and fourth century B.C. The medical knowledge, which had been a privileged inheritance of the ruling class underwent a rapid transformation with the rise of the Roman Empire and its hegemonic politics that reached its climax during the Punic wars. As it was spread to all social classes it achieved an ever increasing importance leading to its specialisation and trading...