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https://www.readbyqxmd.com/read/28894264/seasonal-variation-of-the-dominant-allergenic-fungal-aerosols-one-year-study-from-southern-indian-region
#1
Hema Priyamvada, Raj Kamal Singh, M Akila, R Ravikrishna, Rama Shanker Verma, Sachin S Gunthe
Quantitative estimations of fungal aerosols are important to understand their role in causing respiratory diseases to humans especially in the developing and highly populated countries. In this study we sampled and quantified the three most dominantly found allergenic airborne fungi, Aspergillus fumigatus, Cladosporium cladosporioides, and Alternaria alternata from ambient PM10 samples using the quantitative PCR (qPCR) technique in a southern tropical Indian region, for one full year. Highest concentrations of A...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870728/clinical-use-of-fungal-pcr-from-deep-tissue-samples-in-the-diagnosis-of-invasive-fungal-diseases-a-retrospective-observational-study
#2
Mari Ala-Houhala, Pirkko Koukila-Kähkölä, Jenni Antikainen, Jaana Valve, Juha Kirveskari, Veli-Jukka Anttila
OBJECTIVES: We evaluated the clinical use of panfungal polymerase chain reaction (PCR) for diagnosis of invasive fungal diseases (IFDs). We focused on the deep tissue samples. METHODS: We first described the design of panfungal PCR, which is in clinical use at Helsinki University Hospital. Secondly, we retrospectively evaluated the results of 307 fungal PCR tests performed from 2013-2015. Samples were taken from normally sterile tissues and fluids. The patient population was non-selected...
September 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28868834/recurrent-vulvovaginal-candidiasis-could-it-be-related-to-cell-mediated-immunity-defect-in-response-to-candida-antigen
#3
Zahra Talaei, Saba Sheikhbahaei, Vajihe Ostadi, Mazdak Ganjalikhani Hakemi, Mohsen Meidani, Elham Naghshineh, Majid Yaran, Alireza Emami Naeini, Roya Sherkat
Background: Recurrent vulvovaginal candidiasis (RVVC) is a common cause of morbidity affecting millions of women worldwide. Patients with RVVC are thought to have an underlying immunologic defect. This study has been established to evaluate cell-mediated immunity defect in response to candida antigen in RVVC cases. MATERIALS AND METHODS: Our cross-sectional study was performed in 3 groups of RVVC patients (cases), healthy individuals (control I) and known cases of chronic mucocutaneous candidiasis (CMC) (control II)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28853915/rgs4-overexpression-in-lung-attenuates-airway-hyper-responsiveness-in-mice
#4
Laura A Madigan, Gordon S Wong, Elizabeth M Gordon, Wei-Sheng Chen, Nariman Balenga, Cynthia J Koziol-White, Reynold A Panettieri, Stewart J Levine, Kirk M Druey
A cardinal feature of asthma is airway hyper-responsiveness (AHR) to spasmogens, many of which activate G protein-coupled receptors (GPCRs) on airway smooth muscle (ASM) cells. Asthma subtypes associated with allergy are characterized by eosinophilic inflammation in the lung due to the type 2 immune response to allergens and proinflammatory mediators that promote AHR. The degree to which intrinsic abnormalities of ASM contribute to this phenotype remains unknown. The Regulators of G protein signaling (RGS proteins) are a large group of intracellular proteins that inhibit GPCR signaling pathways...
August 30, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28732432/intradermal-skin-testing-in-allergic-rhinitis-and-asthma-with-negative-skin-prick-tests
#5
Fuat Erel, Nurhan Sarioglu, Mehmet Kose, Mustafa Kaymakci, Mucahide Gokcen, Ahmet Hamdi Kepekci, Mehmet Arslan
Taking medical history, physical examination, and performing some in vivo and in vitro tests are necessary for the diagnosis of allergy. Skin prick test (SPT) is considered as the standard method and first-line approach for the detection of allergic sensitization. Although mainly SPT is used for the detection of allergic sensitization, intradermal skin test (IDST) may be necessary, especially in patients with a negative SPT result. IDST is quite safe; however, is nowadays seldom used for detection of inhalant allergy and its value remains controversial...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28676932/monitoring-of-airborne-fungal-spore-load-in-relation-to-meteorological-factors-air-pollutants-and-allergic-symptoms-in-farakka-an-unexplored-biozone-of-eastern-india
#6
Shipra Roy, Arindom Chakraborty, Saibal Maitra, Kashinath Bhattacharya
Fungi are important components of atmosphere which play a major role in causing respiratory allergy upon inhalation. An airborne fungal spore survey was carried out in two outdoor environments in Farakka-an unexplored township covering the National Thermal Power Station, West Bengal, India for a period of 2 years (October 2013 to September 2015). A Burkard personal volumetric air sampler was used at 15 days interval to collect the total fungal spore load. A fungal spore calendar has been prepared depicting monthly average spore concentration in the air...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28625008/the-role-of-local-allergy-in-the-nasal-inflammation
#7
REVIEW
Ke-Jia Cheng, Min-Li Zhou, Ying-Ying Xu, Shui-Hong Zhou
Local allergic inflammation (LAI) is recognized recently. 'entopy' was used to define LAI, which was positively correlated with allergen provocation testing, local sIgE up-regulation, inflammatory mediator secretion, and a lack of systemic allergy. The study of LAI is in its infancy and focuses mainly on the respiratory system. It is closely related to nasal inflammation and plays important roles in patients with nonallergic rhinitis (NAR), nonallergic chronic sinusitis with nasal polyps (CRSwNP), and nonallergic fungal rhinosinusitis (NAFRS)...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28572995/assessing-the-anti-fungal-efficiency-of-filters-coated-with-zinc-oxide-nanoparticles
#8
Stephen Decelis, Davide Sardella, Thomas Triganza, Jean-Pierre Brincat, Ruben Gatt, Vasilis P Valdramidis
Air filters support fungal growth, leading to generation of conidia and volatile organic compounds, causing allergies, infections and food spoilage. Filters that inhibit fungi are therefore necessary. Zinc oxide (ZnO) nanoparticles have anti-fungal properties and therefore are good candidates for inhibiting growth. Two concentrations (0.012 M and 0.12 M) were used to coat two types of filters (melt-blown and needle-punched) for three different periods (0.5, 5 and 50 min). Rhizopus stolonifer and Penicillium expansum isolated from spoiled pears were used as test organisms...
May 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28535995/inflammation-associated-gene-expression-in-raw-264-7-macrophages-induced-by-toxins-from-fungi-common-on-damp-building-materials
#9
Thomas G Rand, Carolyn T Chang, David R McMullin, J David Miller
Most fungi that grow on damp building materials produce low molecular weight compounds, some of which are known to be toxic. In this study, we tested the hypothesis that exposure to some metabolites of fungi common on damp building materials would result in time-, dose-, and compound-specific responses in the production of various chemokines by RAW 264.7 cells. Cell cultures were exposed to a 10(-7)M or 10(-8)M metabolite dose for 2, 4, 8 or 24h. Metabolite concentrations used were based on those that might be expected in alveolar macrophages due to inhalation exposure from living or working in a damp building...
May 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28453304/mold-allergy-is-it-real-and-what-do-we-do-about-it
#10
Amanda Rudert, Jay Portnoy
fungi produce substances that contain pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) which bind to pattern recognition receptors, stimulating innate immune responses in humans. they also produce allergens that induce production of specific ige. Areas covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause an intense and complex health effects...
May 17, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28437767/building-integrated-agriculture-a-first-assessment-of-aerobiological-air-quality-in-rooftop-greenhouses-i-rtgs
#11
Mireia Ercilla-Montserrat, Rebeca Izquierdo, Jordina Belmonte, Juan Ignacio Montero, Pere Muñoz, Concepción De Linares, Joan Rieradevall
Building-integrated rooftop greenhouse (i-RTG) agriculture has intensified in recent years, due to the growing interest in the development of new agricultural spaces and in the promotion of food self-sufficiency in urban areas. This paper provides a first assessment of the indoor dynamics of bioaerosols in an i-RTG, with the aim of evaluating biological air quality in a tomato greenhouse near Barcelona. It evaluates the greenhouse workers' exposure to airborne pollen and fungal spores in order to prevent allergy problems associated with occupational tasks...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28410152/fungal-immunomodulatory-proteins-in-the-context-of-biomedicine
#12
REVIEW
Paula Tatiana Uribe-Echeverry, German Ariel Lopez-Gartner
Fungi represent a large group of biodiverse microorganisms with potential applications ranging from industrial fields to the treatment for human diseases. A large number of pharmacologically active compounds including terpenoids, polysaccharides and proteins have been derived from these microorganisms. Fungal Immunomodulatory Proteins (FIPs) are a group of active compounds that are being considered for the treatment of asthma, allergy, autoimmune diseases and cancer. Here, we discuss the discovery, heterologous production bioactive mechanisms of action and their potential use in biomedicine...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28380479/serological-reactivity-and-identification-of-immunoglobulin-e-binding-polypeptides-of-ganoderma-applanatum-crude-spore-cytoplasmic-extract-in-puerto-rican-subjects
#13
Frances Vilá-Héreter, Félix E Rivera-Mariani, Benjamín Bolaños-Rosero
BACKGROUND: The allergenic potential of Ganoderma applanatum basidiospores has been demonstrated previously in Puerto Rico. However, basidiomycete allergens are not available for inclusion in allergy diagnostic panels. Therefore, we sought to confirm allergic sensitization to G. applanatum crude spore cytoplasmic extract through reactivity in serological assays and detection of immunoglobulin E (IgE)-binding polypeptides. METHODS: Via an indirect ELISA, serological reactivity was compared between groups of individuals with different allergic profiles...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28374407/cutaneous-manifestations-of-diabetes-mellitus-a-review
#14
REVIEW
Ana Luiza Lima, Tanja Illing, Sibylle Schliemann, Peter Elsner
Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Noninfectious as well as infectious diseases have been described as dermatologic manifestations of diabetes mellitus...
August 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28300143/estimating-the-abundance-of-airborne-pollen-and-fungal-spores-at-variable-elevations-using-an-aircraft-how-high-can-they-fly
#15
Athanasios Damialis, Evangelos Kaimakamis, Maria Konoglou, Ioannis Akritidis, Claudia Traidl-Hoffmann, Dimitrios Gioulekas
Airborne pollen and fungal spores are monitored mainly in highly populated, urban environments, for allergy prevention purposes. However, their sources can frequently be located outside cities' fringes with more vegetation. So as to shed light to this paradox, we investigated the diversity and abundance of airborne pollen and fungal spores at various environmental regimes. We monitored pollen and spores using an aircraft and a car, at elevations from sea level to 2,000 m above ground, in the region of Thesssaloniki, Greece...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299723/mold-and-human-health-a-reality-check
#16
REVIEW
Andrea T Borchers, Christopher Chang, M Eric Gershwin
There are possibly millions of mold species on earth. The vast majority of these mold spores live in harmony with humans, rarely causing disease. The rare species that does cause disease does so by triggering allergies or asthma, or may be involved in hypersensitivity diseases such as allergic bronchopulmonary aspergillosis or allergic fungal sinusitis. Other hypersensitivity diseases include those related to occupational or domiciliary exposures to certain mold species, as in the case of Pigeon Breeder's disease, Farmer's lung, or humidifier fever...
June 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28217107/modulation-of-human-immune-response-by-fungal-biocontrol-agents
#17
REVIEW
Cibele Konstantinovas, Tiago A de Oliveira Mendes, Marcos A Vannier-Santos, Jane Lima-Santos
Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation, resulting in IgE-mediated allergy and immune downmodulation induced by molecules such as cyclosporin A and mycotoxins. This review discusses the potential effects of biocontrol fungal components on human immune responses, possibly associated to infectious, inflammatory diseases, and defective defenses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28194062/performance-of-galactomannan-antigen-beta-d-glucan-and-aspergillus-lateral-flow-device-for-the-diagnosis-of-invasive-aspergillosis
#18
Gökhan Metan, Muzaffer Keklik, Gökçen Dinç, Çiğdem Pala, Afra Yıldırım, Berkay Saraymen, Mustafa Yavuz Köker, Leylagül Kaynar, Bülent Eser, Mustafa Çetin
Aspergillus lateral-flow device (LFD) was recently introduced as a practical tool for the diagnosis of invasive aspergillosis (IA). We investigated the performance of Aspergillus-LFD as a point-of-care test for the diagnosis of IA. Serum samples were collected twice weekly from patients who received intensive chemotherapy for acute leukemia, or recepients of allogeneic stem cell transplantation. Aspergillus galactomannan (GM) antigen, 1,3-beta-d-glucan and Aspergillus-LFD tests were carried out according to manufacturers' recommendations...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28190400/infant-fungal-communities-current-knowledge-and-research-opportunities
#19
REVIEW
Tonya L Ward, Dan Knights, Cheryl A Gale
The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for proper immune and metabolic development. However, most studies to date have focused on bacterial colonization events and have left out fungi, a clinically important sub-population of the microbiota...
February 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28188712/-viable-allergenic-fungi-in-a-documentary-deposit-of-the-national-archive-of-cuba
#20
Alian Molina-Veloso, Sofía F Borrego-Alonso
BACKGROUND: Intense and persistent exposure to indoor-air biological agents has been associated with the appearance of allergic diseases. Archives and libraries Indoor environments in tropical countries are an important reservoir of fungal propagules. OBJECTIVE: To evaluate the degree of air pollution with allergenic fungi in a repository of frequently-manipulated documents. METHODS: Air sampling was performed by two methods: active (biocollector) and passive (sedimentation plate)...
January 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
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