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https://www.readbyqxmd.com/read/29349620/fatal-talaromyces-marneffei-infection-in-a-patient-with-autoimmune-hepatitis
#1
Sally C Y Wong, Siddharth Sridhar, Antonio H Y Ngan, Jonathan H K Chen, Rosana W S Poon, Susanna K P Lau, Patrick C Y Woo
Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies...
January 18, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29274088/autopsy-and-biopsy-study-of-paracoccidioidomycosis-and-neuroparacoccidioidomycosis-with-and-without-hiv-coinfection
#2
Sergio Monteiro de Almeida, Thiago Henrique Roza, Gabriel L O Salvador, Luís Felipe Izycki, Giuliana Locatelli, Isaias Dos Santos, Afonso Aragão, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among immunocompetent patients in Latin America. OBJECTIVE: This study aimed to describe the frequency, demographics, and clinical characteristics of central nervous system PCM (NPCM) and PCM in an endemic region, and the impact of human immunosuppression virus (HIV) co-infection. PATIENTS/METHODS: This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29243020/effect-of-1064-nm-q-switched-nd-yag-laser-on-invasiveness-and-innate-immune-response-in-keratinocytes-infected-with-candida-albicans
#3
Baroni Adone, De Filippis Anna, Oliviero Giovanni, Fusco Alessandra, Perfetto Brunella, Buommino Elisabetta, Donnarumma Giovanna
Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal side effects. The Q-switched (Nd-YAG) laser at a wavelength of 1064 nm has been shown to be useful in dermatology, dentistry, and some other medical specialties. It is used to treat onychomycoses, warts, and wounds and in some other treatments...
December 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29222709/successful-treatment-of-canine-sporotrichosis-with-terbinafine-case-reports-and-literature-review
#4
Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Isabella Dib Ferreira Gremião, Luisa Helena Monteiro de Miranda, Isabela Maria da Silva Antonio, Jéssica Sepulveda Boechat, Ana Caroline de Sá Machado, Manoel Marques Evangelista de Oliveira, Sandro Antonio Pereira
Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. In this context, the effectiveness of terbinafine in the treatment of sporotrichosis in humans, as well as the promising results of in vitro susceptibility tests, inspired us to use this drug in the therapy of this mycosis in dogs...
December 8, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29188072/systemic-rasamsonia-piperina-infection-in-a-german-shepherd-cross-dog
#5
Joanna Lodzinska, Paola Cazzini, Claire S Taylor, Jenifer Harris, Scott Kilpatrick, Tiziana Liuti, Gavin K Paterson
Introduction. Infection with the Rasamsonia argillacea species complex represents an emerging problem in human and veterinary medicine with systemic mycoses presenting with significant clinical complications and being a cause of death. Case presentation. In this report, a case of systemic Rasamsonia piperina infection discovered in a 3-year-old male neutered, German shepherd cross dog is described together with the clinical presentation, the course of the disease and diagnosis. This report describes the first case of veterinary mycosis due to R...
October 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29068084/regional-incidences-of-adult-t-cell-leukemia-lymphoma-with-cutaneous-involvement-in-japan
#6
Toshihisa Hamada, Hayato Nomura, Keiji Iwatsuki
Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type...
October 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28992307/attempted-molecular-detection-of-the-thermally-dimorphic-human-fungal-pathogen-emergomyces-africanus-in-terrestrial-small-mammals-in-south-africa
#7
Nadine Cronjé, Ilan S Schwartz, Liezl Retief, Armanda D S Bastos, Sonja Matthee, Wolfgang Preiser, Nigel C Bennett, Tsidiso Maphanga, Nelesh P Govender, Robert Colebunders, Chris Kenyon
The ecological niche of Emergomyces africanus (formerly Emmonsia species), a dimorphic fungus that causes an AIDS-related mycosis in South Africa, is unknown. We hypothesized that natural infection with E. africanus occurs in wild small mammals. Using molecular detection with primers specific for E. africanus, we examined 1402 DNA samples from 26 species of mole-rats, rodents, and insectivores trapped in South Africa that included 1324 lung, 37 kidney, and 41 liver specimens. DNA of E. africanus was not detected in any animals...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28992125/a-new-method-for-studying-cryptococcosis-in-a-murine-model-using-99mtc-cryptococcus-gattii
#8
Marliete Carvalho Costa, Lays Murta Mata, Noelly de Queiroz Ribeiro, Anderson Philip Nonato Santos, Lorena Vivien Neves Oliveira, Raquel Virgínia Rocha Vilela, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Daniel Assis Santos
Cryptococcus gattii is one of the etiologic agents of cryptococcosis, a systemic mycosis that occurs in healthy and immunosuppressed humans and animals worldwide. Primary pulmonary infection caused by C. gattii is usually followed by fungal dissemination to the central nervous system, resulting in high mortality rates. In this context, animal models of cryptococcosis are useful in the study of fungal pathogenesis and host response against the pathogen, and for testing novel therapeutic options. The most frequently applied method to study fungal dissemination from the lungs to other organs is by culturing tissues, which is not accurate for the detection and quantification of fungal load at early stages of the infection...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28977697/expression-of-fk506-binding-protein-51-fkbp51-in-mycosis-fungoides
#9
M Mascolo, M F Romano, G Ilardi, S Romano, A Baldo, M Scalvenzi, G Argenziano, F Merolla, D Russo, S Varricchio, F Pagliuca, M Russo, G Ciancia, G De Rosa, S Staibano
BACKGROUND: Mycosis fungoides (MF) is the major subtype of cutaneous T-cell lymphomas (CTCL). It usually has a prolonged indolent clinical course with a minority of cases acquiring a more aggressive biological profile and resistance to conventional therapies, partially attributed to the persistent activation of nuclear factor-kappa B (NF-κB) pathway. In the last decade, several papers suggested an important role for the FK506-binding protein 51 (FKBP51), an immunophilin initially cloned in lymphocytes, in the control of NF-κB pathway in different types of human malignancies...
October 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28961208/how-can-elispot-add-information-to-improve-knowledge-on-tropical-diseases
#10
REVIEW
Josué da Costa Lima-Junior, Fernanda Nazaré Morgado, Fátima Conceição-Silva
Elispot has been used as an important tool for detecting immune cells' products and functions and has facilitated the understanding of host-pathogen interaction. Despite the incredible diversity of possibilities, two main approaches have been developed: the immunopathogenesis and diagnosis/prognosis of infectious diseases as well as cancer research. Much has been described on the topics of allergy, autoimmune diseases, and HIV-Aids, however, Elispot can also be applied to other infectious diseases, mainly leishmaniasis, malaria, some viruses, helminths and mycosis usually classified as tropical diseases...
September 29, 2017: Cells
https://www.readbyqxmd.com/read/28948342/pediatric-mycosis-fungoides-a-study-of-the-human-leukocyte-antigen-system-among-israeli-jewish-patients
#11
Ofer Reiter, Dan Ben Amitai, Iris Amitay-Laish, Moshe Israeli, Lev Pavlovsky, Emmilia Hodak
Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. To evaluate the possible association of the HLA system with pediatric MF, 59 Israeli Jewish patients diagnosed with MF at age ≤ 18 years underwent high- and intermediate-resolution genotyping for HLA class I (HLA-A*, HLA-B*) and class II (HLA-DRB1*, DQB1*) loci...
September 25, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28919888/the-sporothrix-schenckii-gene-encoding-for-the-ribosomal-protein-l6-has-constitutive-and-stable-expression-and-works-as-an-endogenous-control-in-gene-expression-analysis
#12
Elías Trujillo-Esquivel, José A Martínez-Álvarez, Diana M Clavijo-Giraldo, Nahúm V Hernández, Alberto Flores-Martínez, Patricia Ponce-Noyola, Héctor M Mora-Montes
Sporothrix schenckii is one of the causative agents of sporotrichosis, a worldwide-distributed mycosis that affects humans and other mammals. The interest in basic and clinical features of this organism has significantly increased in the last years, yet little progress in molecular aspects has been reported. Gene expression analysis is a set of powerful tools that helps to assess the cell response to changes in the extracellular environment, the genetic networks controlling metabolic pathways, and the adaptation to different growth conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28912774/therapeutic-antibodies-to-kir3dl2-and-other-target-antigens-on-cutaneous-t-cell-lymphomas
#13
REVIEW
Christian Schmitt, Anne Marie-Cardine, Armand Bensussan
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. Beside its expression on NK cells, it is also found on rare circulating T lymphocytes, mainly CD8(+). Although the KIR gene number varies between haplotype, KIR3DL2 is a framework gene present in all individuals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28891112/candida-albicans-isolates-from-a-single-hospital-show-low-phenotypical-specialization
#14
Enikő Boros, Walter P Pfliegler, Renátó Kovács, Ágnes Jakab, László Majoros, Zoltán Barta, István Pócsi
Candida albicans is the best-studied opportunistic human pathogenic yeast species, and its virulence factors, susceptibility to antimycotics, the diversity of its physiological properties and the determinative factors of these traits are interesting from a clinical as well as from an evolutionary perspective. By applying statistical modeling for the phenotypical differences observed among a collection of 63 C. albicans isolates originating from different clinical care units, from a diverse group of patients with or without mycosis, collected in a Hungarian clinic, we found that (i) host-related aspects like anatomical source, care unit of isolation, patients' age, sex, and disease severity, or ABC genotypes of the isolates had less effect on the phenotypic features of this opportunistic pathogen than host-independent aspects, for example, year or month of isolation; (ii) different phenotypic traits did not show any significant correlations with each other; and (iii) different genotypes displayed no anatomical specialization and rarely showed any significant correlation with parameters of isolation either...
September 11, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28719322/case-report-disseminated-talaromyces-penicillium-marneffei-and-mycobacterium-tuberculosis-coinfection-in-a-japanese-patient-with-acquired-immunodeficiency-syndrome
#15
Shuji Hatakeyama, Takeshi Yamashita, Toshiyasu Sakai, Katsuhiko Kamei
Talaromyces marneffei is a dimorphic fungus endemic mainly in southeast and south Asia. It causes severe mycosis, usually in immunocompromised individuals, such as those with human immunodeficiency virus (HIV) infection. Concomitant infection with T. marneffei and other opportunistic pathogens is plausible because the majority of T. marneffei infections occur in patients with advanced HIV infection. Nonetheless, coinfection in the same site has rarely been reported, and poses a considerable diagnostic and therapeutic challenge...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28698667/phylogenetic-analysis-reveals-two-genotypes-of-the-emerging-fungus-mucor-indicus-an-opportunistic-human-pathogen-in-immunocompromised-patients
#16
Saad J Taj-Aldeen, Muna Almaslamani, Bart Theelen, Teun Boekhout
Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28633410/cryptococcus-neoformans-and-gattii-promote-dna-damage-in-human-peripheral-blood-mononuclear-cells
#17
Jéssica Cristina Bilizario Noguerol Andrade, Mariana Gatto, Daniela Ramos Rodrigues, Ângela Maria Victoriano de Campos Soares, Sueli Aparecida Calvi
Cryptococcosis, a systemic mycosis capable of disseminating to the central nervous system with frequent lethal effects, is caused by the species Cryptococus neoformans and Cryptococcus gattii. Several infectious agents such as virus, bacteria, and parasites may be associated to DNA damage and carcinogenesis in humans. Products of the oxidative metabolism, such as NO, produced as a host defense mechanism to destroy these pathogens, have been implicated in this damage process, due to excessive production related to an established chronic inflammatory response...
June 15, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28627488/diversity-of-veronaea-botryosa-from-different-hosts-and-evaluation-of-laboratory-challenge-models-for-phaeohyphomycosis-in-acipenser-transmontanus
#18
Esteban Soto, Christine Richey, Stephen R Reichley, Brittany Stevens, Kirsten V Kenelty, Janiee Lewis, Barbara Byrne, Nathan P Wiederhold, Thomas B Waltzek, Matthew F Sheley, Alvin C Camus, Matt J Griffin
Veronaea botryosa has been identified as a pathogen of cultured white sturgeon Acipenser transmontanus. In 2015, samples from 19 white sturgeon were received for diagnosis, of which 14 cultured positive for V. botryosa. Intraspecific variability among V. botryosa isolates from different clinically affected hosts and geographic regions was investigated using repetitive extragenic palindromic PCR fingerprinting (rep-PCR). The rep-PCR profiles of 16 V. botryosa isolates from a human, sea turtles, and cultured fish were distinct from those of other phaeoid fungi belonging to the genera Cladophialophora and Exophiala...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28627095/sporotrichosis-masquerading-as-pyoderma-gangrenosum
#19
R B Lima, M A J Jeunon-Sousa, T Jeunon, J C Oliveira, M M E Oliveira, R M Zancopé-Oliveira, A C S Moraes
Sporotrichosis is a subcutaneous mycosis with a worldwide distribution caused by species of the Sporothrix schenkii complex. Since 1998, it has reached epidemic proportions in the city of Rio de Janeiro, Brazil, via transmission from infected cats to humans. The species identified as the primary cause was Sporothrix brasiliensis. This article is protected by copyright. All rights reserved.
June 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28584987/peptide-vaccine-against-paracoccidioidomycosis
#20
Carlos P Taborda, Luiz R Travassos
The chapter reviews methods utilized for the isolation and characterization of a promising immunogen candidate, aiming at a human vaccine against paracoccidioidomycosis. Peptide P10 carries a T-CD4+ epitope and was identified as an internal sequence of the major diagnostic antigen known as gp43 glycoprotein. It successfully treated massive intratracheal infections by virulent Paracoccidioides brasiliensis in combination with chemotherapy.An introduction about the systemic mycosis was found essential to understand the various options that were considered to design prophylactic and therapeutic vaccine protocols using peptide P10...
2017: Methods in Molecular Biology
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