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Chondrosarcoma

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https://www.readbyqxmd.com/read/29342030/mesenchymal-chondrosarcoma-of-the-lacrimal-gland
#1
Hayyam Kiratli, Yağmur Deniz, Berrin Büyükeren, Gökhan Gedikoğlu
A 23-year-old woman presented with right-sided painless proptosis that developed in 12 months. MRI studies demonstrated a well-delineated tumorous enlargement of the right lacrimal gland with homogenous signal intensity and compressing the globe. The tumor was removed totally and in 1 piece with the tentative diagnosis of a pleomorphic adenoma. Pathologic examination revealed biphasic neoplastic elements, which were composed of the cartilaginous matrix and small round cell component. Immunohistopathological examination showed positive CD99 staining and negative reaction to S100, panCK, and CD15...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29339836/the-role-of-metabolic-enzymes-in-mesenchymal-tumors-and-tumor-syndromes-genetics-pathology-and-molecular-mechanisms
#2
REVIEW
Inga-Marie Schaefer, Jason L Hornick, Judith V M G Bovée
The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur in enchondromas and chondrosarcomas in patients with the non-hereditary enchondromatosis syndromes Ollier disease and Maffucci syndrome and in sporadic tumors. IDH1/2 mutations result in excess production of the oncometabolite (D)-2-hydroxyglutarate...
January 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29332366/molecular-landscape-in-laryngeal-chondrosarcoma
#3
Eleftheria Gletsou, Panagiotis P Fotiades, Evangelos Tsiambas, Vasileios Ragos
No abstract text is available yet for this article.
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332118/primary-extraskeletal-mesenchymal-chondrosarcoma-arising-from-the-iliac-vein
#4
Mahmood D Al-Mendalawi
[No Abstract Available].
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29327709/insm1-expression-and-its-diagnostic-significance-in-extraskeletal-myxoid-chondrosarcoma
#5
Akihiko Yoshida, Naohiro Makise, Susumu Wakai, Akira Kawai, Nobuyoshi Hiraoka
Extraskeletal myxoid chondrosarcoma is a rare subtype of sarcoma that affects the soft tissue and bones in middle-aged and elderly adults. Its diagnosis can be challenging, with the differential diagnoses including a wide variety of mesenchymal tumors. The line of differentiation of extraskeletal myxoid chondrosarcoma has been controversial, but recent evidence suggests a neuroendocrine phenotype. INSM1 is a zinc-finger transcription factor that plays a pivotal role in neuroendocrine differentiation, and has been proposed as a promising immunohistochemical marker of neuroendocrine carcinoma...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29318761/suitability-of-the-cellienttm-cell-block-method-for-diagnosing-soft-tissue-and-bone-tumors
#6
W Song, B M van Hemel, A J H Suurmeijer
BACKGROUND: The diagnosis of tumors of soft tissue and bone (STB) heavily relies on histological biopsies, whereas cytology is not widely used. CellientTM cell blocks often contain small tissue fragments. In addition to Hematoxylin and Eosin (H&E) interpretation of histological features, immunohistochemistry (IHC) can be applied after optimization of protocols. The objective of this retrospective study was to see whether this cytological technique allowed us to make a precise diagnosis of STB tumors...
January 10, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29316907/expression-of-mmp-9-decreases-metastatic-potential-of-chondrosarcoma-an-immunohistochemical-study
#7
Dominik Malcherczyk, Thomas J Heyse, Bilal F El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann, Jürgen R J Paletta
BACKGROUND: Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that will allow for a more accurate estimation of prognosis in patients with these tumors. Matrix metalloproteinases (MMP) play a crucial role in tumor progression, invasion and metastasis. The mechanism of tumor progression dependent of MMPs is complex and influences malignant transformation, angiogenesis and tumor growth at the primary and metastatic sites...
January 9, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29312725/contributing-factors-to-the-outcome-of-primary-malignant-chest-wall-tumors
#8
Abdel Rahman Mohamed Abdel Rahman, Mohamed Rahouma, Rabab Gaafar, Sherif Bahaa, Iman Loay, Mohamed Kamel, Hoda Abdelbaki, Maha Yahia
Background: Primary malignant chest-wall tumors (PMCWTs) are a heterogeneous group of tumors. They require a special experience in designing resection and reconstruction. They account for less than 1% of all primary malignant tumors. This study is designed to clarify different factors contributing to the outcome of patients with PMCWTs in our institution. Methods: A retrospective study included 98 patients with pathology proven PMCWTs, treated at the National Cancer Institute (NCI), Cairo University, Egypt, during the past 10 years...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29309691/prospective-study-to-evaluate-the-safety-of-the-world-first-spot-scanning-dedicated-small-360-degree-gantry-synchrotron-based-proton-beam-therapy-system
#9
Kentaro Nishioka, Anussara Prayongrat, Kota Ono, Shunsuke Onodera, Takayuki Hashimoto, Norio Katoh, Tetsuya Inoue, Rumiko Kinoshita, Koichi Yasuda, Takashi Mori, Rikiya Onimaru, Hiroki Shirato, Shinichi Shimizu
This is a report of a single-institution prospective study evaluating the safety of a spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy (PBT) system. Data collection was performed for 56 patients with 59 treatment sites who received proton beam therapy at Hokkaido University Hospital between March 2014 and July 2015. Forty-one patients were male and 15 were female. The median age was 66 years. The primary lesion sites were prostate (n = 17), bone/soft tissue (n = 10), liver (n = 7), lung (n = 6), central nervous system (n = 5), colon (n = 2), pancreas (n = 2), kidney (n = 2) and others (n = 5)...
December 22, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29309041/first-application-of-segmental-trabecular-metal-cones-in-a-custom-made-revision-tumor-prosthesis-of-the-knee-a-technical-note
#10
Roslind Karolina Hackenberg, Jochen Nessler, Dietmar Pierre König
BACKGROUND: Tumor prostheses are established as a standard procedure in tumors of the lower extremities. Septic and aseptic loosening remains the main reason for the failure of tumor prostheses. Due to bone defects, the possibilities of anchoring revision prostheses are limited. Trabecular metal cones are established in prosthetic revision surgery. However, the use of segmental trabecular metal cones in a custom-made tumor revision prosthesis has not yet been described. OBJECTIVE: A 58-year-old patient, who initially received a resection of the distal femur and reconstruction with a tumor prosthesis due to chondrosarcoma, attended our clinic...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29302765/anti-inflammatory-effect-of-dna-polymeric-molecules-in-a-cell-model-of-osteoarthritis
#11
Ahreum Baek, MinGi Kim, Sung Hoon Kim, Sung-Rae Cho, Hyun Jung Kim
The DNA polymeric molecules polydeoxynucleotide (PDRN) and polynucleotide (PN) can be used as new alternative treatment for osteoarthritis (OA); however, the underlying mechanisms are not fully understood. In this study, we investigated the effect of PDRN and PN on gene-expression profiles in a cell model of OA using transcriptome analysis. Under hypoxic conditions, human chondrosarcoma cells were stressed for 24 h in the presence of interleukin (IL)-1β and subsequently treated with PDRN, PN, or hyaluronic acid (HA) for another 24 h, followed by transcriptome analysis...
January 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29275381/maxillary-chondrosarcoma-mimicking-torus-palatinus
#12
Marina Brimioulle, Philippe Frederick Bowles, Andrew Pelser
No abstract text is available yet for this article.
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29274624/interferon-regulatory-factor-5-irf5-regulates-the-expression-of-matrix-metalloproteinase-3-mmp-3-in-human-chondrocytes
#13
Lin Guo, Ruihu Hao, Fengde Tian, Ning An, Kunzheng Wang
Matrix metalloproteinase-3 (MMP-3) plays a pivotal role in the destruction of articular cartilage in osteoarthritis (OA). The regulation of gene expression of MMP-3 is complicated. Interferon regulatory factor 5 (IRF5) is a member of the interferon regulatory factor family of transcription factors. Little information regarding the biological function of IRF5 on chondrocytes and the pathogenesis of OA has been reported. In the current study, for the first time, we report that IRF5 is expressed in human primary chondrocytes and human chondrosarcoma cell line SW1353 cells...
December 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29261626/18f-fdg-pet-ct-in-diagnostic-and-prognostic-evaluation-of-patients-with-suspected-recurrence-of-chondrosarcoma
#14
Shelvin Kumar Vadi, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Ashwani Sood, Rajender Kumar Basher, Apurva Sood, Nandita Kakkar, Ramesh K Sen
PURPOSE: The aim of the study was to analyze the diagnostic and prognostic utility of F-FDG PET/CT to predict the disease-specific survival (DSS) with FDG uptake and tumor grade in recurrent chondrosarcoma. METHODS: Retrospective analysis of FDG PET/CT findings in 31 previously treated patients (46 studies) with mean follow-up period of 40.7 ± 23.9 months (range, 3-77 months) from the date of first PET/CT study was done. Kaplan-Meier DSS analysis was made with respect to tumor grade, FDG uptake at the recurrent primary sites, and a combination of grade and FDG uptake as parameters...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29238848/biology-of-bone-sarcomas-and-new-therapeutic-developments
#15
REVIEW
Hannah K Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis...
December 13, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29236139/-notochordal-tumors-benign-notochordal-tumors-and-chordomas
#16
REVIEW
T F E Barth, A von Witzleben, P Möller, S Scheil-Bertram
Benign notochordal tumors (BNCT) and chordomas are primary bone tumors of the spine with a predominant localization in the sacrum and clival region followed by the vertebral bodies. Besides the most common variant (NOS [not otherwise specified] with hepatoid or renal carcinoma cell-like differentiation) chordomas with chondroid, and polymorphic to anaplastic morphology are described. An unfavorable variant are pediatric chordomas with a loss of INI-1. BNCT and chordomas are characterized by the following immunohistological profile: vimentin+, cytokeratin+/-, epithelial membrane antigen (EMA)+/-, S100 protein+/-, brachyury+...
December 13, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29234663/reconstruction-with-iliac-pedestal-cup-and-proximal-femur-tumor-prosthesis-after-wide-resection-of-chondrosarcoma-10-year-follow-up-results
#17
Diogo Lino Moura, Rúben Fonseca, João Freitas, António Figueiredo, José Casanova
Chondrosarcoma is a malignant cartilage-forming neoplasm. It is difficult to treat because of resistance to both chemotherapy and radiation, making wide local excision the only treatment. This report presents an active, 43 year-old man who was diagnosed with recurrent clear cell chondrosarcoma of the proximal left femur, previously reconstructed with a total hip prosthesis, extending to the weight-bearing dome of the acetabulum. Cancer staging study revealed no signs of tumor dissemination at distance. Given the excellent functional status of the patient, the authors performed a Enneking-Dunham type periacetabular pelvic resection and resected en bloc, with the total hip prosthesis including 22 cm of the femur and a portion of the hip abductor apparatus...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29232802/-sarcomatoid-urothelial-carcinoma-of-the-bladder-including-an-osteosarcoma-element
#18
Kouzaburou Tanuma, Koji Kawai, Haruki Tsuchiya, Yoshitaka Matsumoto, Shuya Kandori, Takahiro Kojima, Tomokazu Kimura, Akira Joraku, Jun Miyazaki, Hiroyuki Nishiyama, Akiko Sakata
A 68-year-old Japanese man was referred to Tsukuba University Hospital for bladder cancer treatment. He had undergone a transurethral resection of a bladder tumor (TURBT) at a local hospital, but the pathological specimen did not contain muscle layer. Abdominal computed tomography (CT) and magnetic resonance imaging revealed a 3 cm non-papillary bladder tumor with muscle invasion, but there was no apparent calcification. The patient underwent re-TURBT at our hospital for diagnosis and staging. A non-papillary pedunculated tumor was identified in the bladder dome, and it contained a small papillary part...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29230266/-shoulder-tumor-of-startling-appearance
#19
Ilhame Naciri, Baderddine Hassam
Chondrosarcoma is a malignant tumor of bone of mesenchymal origin which usually occurs in people after age 40 at the level of the pelvis and the shoulder. We report the case of a 65-year old female patient, with no particular past medical history, with impaired general condition, hospitalized for exploration of a large tumor of the right shoulder, evolving over 3 years. Clinical examination showed giant, humpbacked, hard, adherent tumor measuring 44 × 32 cm along its longer axis, with inflammatory signs associated with signs of vasculo-nervous compression...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229475/a-huge-mass-in-a-boy-s-chest-an-unusual-case-of-mesenchymal-chondrosarcoma
#20
Min Li, Rongchun Wang, Zhuang Luo
No abstract text is available yet for this article.
December 8, 2017: Archivos de Bronconeumología
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