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Chondrosarcoma

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https://www.readbyqxmd.com/read/29783007/intracranial-mesenchymal-chondrosarcoma-report-of-16-cases
#1
Xiujian Ma, Ke Wang, Teng-Xian Guo, Liang Wang, Da Li, Shu-Yu Hao, Gui-Jun Jia, Wang Jia, Jun-Ting Zhang, Li-Wei Zhang, Zhen Wu
OBJECTIVES: Limited data about intracranial mesenchymal chondrosarcoma (MCS) are available. The goal of this study was to report the clinical characteristics, challenges in management and poor outcomes of intracranial MCS. METHODS: Clinical data of 16 patients with MCS were reviewed retrospectively to evaluate their clinical characteristics, management and outcomes. RESULTS: This study included 11 male and 5 female patients with a mean age of 22...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29782347/current-questions-in-bone-sarcomas
#2
Sandra J Strauss, Jeremy S Whelan
PURPOSE OF REVIEW: Osteosarcoma and Ewing sarcoma, the most common primary bone tumours in young people, are curable in most patients. However, these tumours remain a significant challenge due to the complexity and intensity of treatment and its long-term morbidity and the significant proportion of patients in whom treatment is unsuccessful. This review addresses questions about current management and emerging therapeutic targets for patients with osteosarcoma, Ewing sarcoma and chondrosarcoma, the commonest bone sarcoma but more common in older patients...
May 17, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29774790/clear-cell-chondrosarcoma-with-chondroblastoma-like-features-a-case-for-team-diagnosis
#3
Ryan M Kiefer, John Wojcik, Kumarasen Cooper, Kristy L Weber, Ronnie Sebro
Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Magnetic resonance imaging demonstrated a marrow-infiltrative lesion with periosteal reaction and thickened enhancing periosteum...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29774752/effects-of-ethanol-on-the-anticancer-function-of-doxorubicin-in-jj012-cells
#4
Hui Huang, Yanze Li, Mingjuan Wu, Jing Luo, Junhui Nie, Baoyu Hou, Qi He, Yan Diao, Lin Qi, Yuanyuan Zhao, Ying Liu, Dan Yang, Lingyun Zhou
AIM: Chondrosarcoma is difficult to treat because of resistance to conventional chemotherapy and radiotherapy. This study evaluated the effects of ethanol in combination with doxorubicin in chondrosarcoma cells. MATERIALS & METHODS: JJ012, was treated with doxorubicin alone or in combination with ethanol. Effects on cellular proliferation, migration, invasion, apoptosis, and the cell cycle were evaluated. RESULTS: Treatment of JJ012 cells with 100 mM ethanol and doxorubicin resulted in reduced cell growth, invasion, and migration...
May 18, 2018: Future Oncology
https://www.readbyqxmd.com/read/29773061/development-of-novel-therapeutics-targeting-isocitrate-dehydrogenase-mutations-in-cancer
#5
Horrick Sharma
Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (αKG). IDH 1 and IDH2 regulate several cellular processes, including oxidative respiration, glutamine metabolism, lipogenesis, and cellular defense against oxidative damage. Mutations in IDH1 and IDH2 have recently been observed in multiple tumor types, including gliomas, acute myeloid leukemia, myelodysplastic syndromes, and chondrosarcoma. IDH1 and IDH2 mutations involve a gain in neomorphic activity that catalyze αKG conversion to (R)-2-hydroxyglutarate ((R)-2HG)...
May 17, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29771927/computer-assisted-surgery-compared-to-fluoroscopy-in-curettage-of-atypical-cartilaginous-tumors-chondrosarcoma-grade-1-in-the-long-bones
#6
J G Gerbers, E F Dierselhuis, M Stevens, J J W Ploegmakers, S K Bulstra, P C Jutte
INTRODUCTION: Fluoroscopy is currently the standard imaging modality for curettage of atypical cartilaginous tumors/chondrosarcoma grade 1 (ACT/CS1). Computer-assisted surgery (CAS) is a possible alternative, offering higher resolution imaging and continuous three-dimensional feedback without ionizing radiation use. CAS hypothetically makes curettage more accurate, thereby decreasing residue or recurrence rate. This study aims to compare CAS and fluoroscopy in curettage of ACT/CS1. PATIENTS AND METHODS: A single center retrospective cohort study was performed...
2018: PloS One
https://www.readbyqxmd.com/read/29759564/biological-aspects-of-chondrosarcoma-leaps-and-hurdles
#7
REVIEW
Benoîte Mery, Sophie Espenel, Jean-Baptiste Guy, Chloé Rancoule, Alexis Vallard, Marie-Thérèse Aloy, Claire Rodriguez-Lafrasse, Nicolas Magné
Chondrosarcomas are characterized by their chemo- and radioresistance leading to a therapeutic surgical approach which remains the only available treatment with a 10-year survival between 30% and 80% depending on the grade. Non-surgical treatments are under investigation and rely on an accurate biological understanding of drug resistance mechanisms. Novel targeted therapy which represents a new relevant therapeutic approach will open new treatment options by targeting several pathways responsible for processes of proliferation and invasion...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29755276/primary-mesenchymal-chondrosarcoma-of-the-orbit-histopathological-report-of-3-pediatric-cases
#8
Hind M Alkatan, Charles G Eberhart, Khalid M Alshomar, Sahar M Elkhamary, Azza M Y Maktabi
Mesenchymal chondrosarcoma (MCS) is an unusual tumor mainly found in the skeleton. Around third of the cases occur in extra-skeletal sites with the orbit being the third most common site in these cases. In previous reviews of the orbital cases, it has been concluded that orbital MCS tends to occur in women in the second or third decades of life. However, 8 cases of orbital MCS have been reported so far in the pediatric age group (age less than 18 years-old) one of which has been considered congenital MCS in a 5-days old newborn girl...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29744065/emergence-of-nasal-chondrosarcoma-in-a-dog-with-nasal-polyposis
#9
Judd A Sumner, Adrian I Witham, Andrew W Stent, Paul F Wightman, Caroline S Mansfield
Whilst the malignant transformation of nasal polyps or secondary development of nasal neoplasia after chronic inflammation is likely to be relatively rare, this potential complication should be considered, and the clinician should be vigilant for evidence of malignant transformation.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29737103/-therapeutic-effect-of-uncemented-allograft-prosthetic-composite-for-the-reconstruction-of-tumorous-bone-defect
#10
Yan-Ling Wang, Li Min, Hong Duan, Yong Zhou, Wei-Li Zhang, Rui Shi, Yi Luo, Chong-Qi Tu
OBJECTIVE: To investigate the surgical techniques and mid-term efficacy of reconstruction for proximal femur with allograft-prosthetic composite (APC) . METHODS: Fifteen patients who underwent uncemented APC reconstruction of proximal femur after bone tumor resection were retrospectively evaluated. Image and physical examinations were taken on the 1st,3rd,6th,9th and 12th month after surgery and every 6 months thereafter to assess union condition,greater trochanteric bone absorption and myodynamia of abductors...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29730230/resistin-facilitates-vegf-c-associated-lymphangiogenesis-by-inhibiting-mir-186-in-human-chondrosarcoma-cells
#11
Chen-Ming Su, Chih-Hsin Tang, Meng-Ju Chi, Chih-Yang Lin, Yi-Chin Fong, Yueh-Ching Liu, Wei-Cheng Chen, Shih-Wei Wang
Chondrosarcoma is a common primary malignant tumor of the bone that can metastasize through the vascular system to other organs. A key step in the metastatic process, lymphangiogenesis, involves vascular endothelial growth factor-C (VEGF-C). However, the effects of lymphangiogenesis in chondrosarcoma metastasis remain to be clarified. Accumulating evidence shows that resistin, a cytokine secreted from adipocytes and monocytes, also promotes tumor pathogenesis. Notably, chondrosarcoma can easily metastasize...
May 3, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29725455/alternative-lengthening-of-telomeres-phenotype-and-loss-of-atrx-expression-in-sarcomas
#12
REVIEW
Xiaolei Ren, Chao Tu, Zhenchu Tang, Ruofei Ma, Zhihong Li
Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently associated with α-thalassemia syndrome. Cancer cells depend on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative programmed mortality...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29724496/how-to-diagnose-enchondroma-bone-infarct-and-chondrosarcoma
#13
REVIEW
Michael E Mulligan
Enchondromas are among the most common benign tumors seen in the skeleton. They are encountered frequently in routine clinical practice. The purpose of this review is to help radiologists confidently diagnose enchondroma and distinguish it from other entities, such as bone infarct, bone graft, and low-grade chondrosarcoma.
April 6, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29721355/pituitary-fossa-chondrosarcoma-an-unusual-cause-of-a-sellar-suprasellar-mass-masquerading-as-pituitary-adenoma
#14
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind Kumar Srivastava, Anita Jagetia, Deepashu Sachdeva
Background: Chondrosarcoma is a mesenchymal malignant tumor composed of tumor cells producing cartilage. It is more commonly found in older age group and usually affects the axial skeleton. Intracranial chondrosarcoma is extremely rare, and chondrosarcoma arising from the sellar region are even rarer with only a few cases described in the literature. We report a case of chondrosarcoma mimicking a sellar suprasellar mass with parasellar extension. Case Description: A 22-year old male presented with generalized intermittent headache along with diplopia and diminished visual acuity without any history of sexual dysfunction or galactorrhea...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29721343/secondary-chondrosarcoma-presenting-with-symptoms-similar-to-thoracic-outlet-syndrome
#15
Hiroshi Kobayashi, Masachika Ikegami, Tetsuo Ushiku, Masaki Anraku, Takahiro Ohki, Yusuke Shinoda, Sakae Tanaka, Hirotaka Kawano
Thoracic outlet syndrome (TOS) is caused by heterogeneous factors that compress the brachial plexus and subclavian artery; tumor is rarely a cause of TOS. Here, we present the case of a 26-year-old man with secondary chondrosarcoma arising from osteochondroma of the left clavicle causing TOS, with a direct compression of the brachial plexus and subclavian artery. Immediately after surgery, the symptoms of TOS reduced. To our knowledge, this is the first case of a secondary chondrosarcoma of the clavicle causing TOS, which is possibly the key symptom for diagnosing malignant transformation of osteochondroma of the clavicle...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29701260/c-reactive-protein-an-independent-predictor-for-dedifferentiated-chondrosarcoma
#16
Elena Nemecek, Philipp Theodor Funovics, Gerhard Martin Hobusch, Susanna Lang, Madeleine Willegger, Florian Sevelda, Thomas Brodowicz, Christoph Stihsen, Reinhard Windhager, Joannis Panotopoulos
Dedifferentiated chondrosarcoma is a rare primary bone malignancy with a very poor prognosis. The aim of the study was to identify pretreatment serum markers as prognostic factors for the overall survival (OS) of patients with dedifferentiated chondrosarcoma. We retrospectively reviewed 33 patients with histologically confirmed dedifferentiated chondrosarcoma treated at our department from 1977 to 2015. Kaplan-Meier estimation, uni- and multivariable Cox proportional hazard model were performed to evaluate the association between serum markers such as the C-reactive protein and OS...
April 27, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29701096/the-role-of-grade-in-local-recurrence-and-the-disease-specific-survival-in-chondrosarcomas
#17
M K Laitinen, J D Stevenson, M C Parry, V Sumathi, R J Grimer, L M Jeys
Aims The purpose of this study was to describe the effect of histological grade on disease-specific survival in patients with chondrosarcoma. Patients and Methods A total of 343 patients with a chondrosarcoma were included. The histological grade was assessed on the initial biopsy and on the resection specimen. Where the histology showed a mixed grade, the highest grade was taken as the definitive grade. When only small focal areas showed higher grade, the final grade was considered as both. Results The concordance between the highest preoperative biopsy grading and the highest final grading of the resection specimen in total was only 43% (146/343)...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29701086/longer-duration-of-symptoms-at-the-time-of-presentation-is-not-associated-with-worse-survival-in-primary-bone-sarcoma
#18
J M Lawrenz, J F Styron, M Parry, R J Grimer, N W Mesko
Aims The primary aim of this study was to determine the effect of the duration of symptoms (DOS) prior to diagnosis on the overall survival in patients with a primary bone sarcoma. Patients and Methods In a retrospective analysis of a sarcoma database at a single institution between 1990 and 2014, we identified 1446 patients with non-metastatic and 346 with metastatic bone sarcoma. Low-grade types of tumour were excluded. Our data included the demographics of the patients, the characteristics of the tumour, and the survival outcome of patients...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29697657/-a-clinical-observation-of-laryngeal-chondrosarcoma
#19
D M Mustafaev
No abstract text is available yet for this article.
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#20
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
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