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Chondrosarcoma

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https://www.readbyqxmd.com/read/27900545/functional-and-oncological-outcome-after-surgical-resection-of-the-scapula-and-clavicle-for-primary-chondrosarcoma
#1
S P F T Nota, M J A M Russchen, K A Raskin, H J Mankin, F J Hornicek, J H Schwab
PURPOSE: The scapula is a relatively common site for chondrosarcoma to develop in contrary to the clavicle, which is rarely affected by these tumors. The aim of this study is to determine the functional and oncological outcome for patients treated operatively for scapular or clavicular chondrosarcoma. METHODS: In this single-center retrospective study, we included a sample of 20 patients that received the diagnosis of a primary chondrosarcoma of the scapula or clavicle...
November 29, 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900099/effect-of-cytostatic-proline-rich-polypeptide-1-on-tumor-suppressors-of-inflammation-pathway-signaling-in-chondrosarcoma
#2
Karina Galoian, Shihua Luo, Amir Qureshi, Parthik Patel, Rachel Price, Ashlyn S Morse, Gor Chailyan, Silva Abrahamyan, H T Temple
Cytokines produced in the tumour microenvironment exert an important role in cancer pathogenesis and in the inhibition of disease progression. Cancer of the cartilage is termed metastatic chondrosarcoma; however, the signaling events resulting in mesenchymal cell transformation to sarcoma have yet to be fully elucidated. The present study aimed to characterize the cytokine expression profile in the human JJ012 chondrosarcoma cell line, as well as the effect of cytostatic proline-rich polypeptide-1 (PRP-1). Western blot experiments demonstrated that the levels of suppressor of cytokine signaling 3 (SOCS3) were upregulated in chondrocytes compared with chondrosarcoma cells...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27895770/classical-intracranial-chondrosarcoma-a-case-report
#3
Jingyang Chi, Mingchao Zhang, Jianmin Kang
Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had lasted for 2 years. Physical and neurological examinations were normal. Radiography of the skull identified an opaque lesion in the left frontal region of the brain. Cranial computed tomography and magnetic resonance imaging revealed a lesion with calcification and homogenous contrast enhancement in the left frontal region...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889461/intralesional-curettage-of-central-low-grade-chondrosarcoma-a-midterm-follow-up-study
#4
Yi-Chou Chen, Po-Kuei Wu, Cheng-Fong Chen, Wei-Ming Chen
BACKGROUND: The aim of this study was to review the experience of surgical treatment of low-grade chondrosarcoma and to assess the long-term oncological and functional outcomes between intralesional curettage and wide excision. METHODS: We included 11 patients with central low-grade chondrosarcoma lesions treated with intralesional curettage or wide excision from 1998 to 2013. Seven patients were treated with intralesional curettage and local adjuvant treatment (Group A), and four patients were treated with wide excision and reconstructive surgery (Group B)...
November 23, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27889090/focal-nodular-and-diffuse-haematopoietic-marrow-hyperplasia-in-patients-with-underlying-malignancies-a-radiological-mimic-of-malignancy-in-need-of-recognition
#5
L T C Chow, A W H Ng, S K C Wong
AIM: To report the authors' experience of focal nodular haematopoietic marrow hyperplasia (FNHMH) and diffuse haematopoietic marrow hyperplasia (DHMH) clinically masquerading as skip, distant, or disseminated metastasis in seven patients with underlying malignant neoplasms. MATERIALS AND METHODS: Five patients with FNHMH and two with DHMH mistaken radiologically as skip and disseminated metastasis, respectively, were compared and contrasted with four patients with osteosarcomas and two with chondrosarcomas harbouring skip metastasis, noting the temporal relationship with their haematological profile...
November 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27881681/a-novel-regulatory-mechanism-of-type-ii-collagen-expression-via-a-sox9-dependent-enhancer-in-intron-6
#6
Hideyo Yasuda, Chun-Do Oh, Di Chen, Benoit de Crombrugghe, Jin-Hoi Kim
Type II collagen α1 is specific for cartilaginous tissues, and mutations in its gene are associated with skeletal diseases. Its expression has been shown to be dependent on SOX9, a master transcription factor required for chondrogenesis that binds to an enhancer region in intron 1. However, ChIP-sequencing revealed that SOX9 does not strongly bind to intron 1, but rather it binds to intron 6 and a site 30 kb upstream of the transcription start site. Here, we aimed to determine the role of the novel SOX9-binding site in intron 6...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27871571/spine-tumor-resection-among-patients-who-refuse-blood-product-transfusion-a-retrospective-case-series
#7
Alexandra E Kisilevsky, Liam Stobart, Kristine Roland, Alana M Flexman
STUDY OBJECTIVE: To describe the perioperative blood conservation strategies and postoperative outcomes in patients who undergo complex spinal surgery for tumor resection and who also refuse blood product transfusion. DESIGN: A retrospective case series. SETTING: A single-center, tertiary care and academic teaching hospital in Canada. PATIENTS: All adult patients undergoing elective major spine tumor resection and refusing blood product transfusion who were referred to our institutional Blood Utilization Program between June 1, 2004, and May 9, 2014...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27852363/-hemothorax-caused-by-primary-pleural-chondrosarcoma-a-case-report-and-review-of-literatureyuan
#8
Y Q Yuan, L Y Zhu, H H Zeng, R Zhou, P Chen
Objective: To analyze the clinical features of one case of spontaneous hemothorax caused by primary pleural chondrosarcoma and therefore to improve the understanding of this disease. Methods: The clinical features of a case with primary pleural chondrosarcoma were analyzed retrospectively and the related literatures were reviewed.The literature review was carried out with "primary pleural, chondrosarcoma" in Chinese and English respectively, as the search terms in Wanfang Data, CNKI and PubMed database from January 1980 to October 2015...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27847738/temporomandibular-joint-chondrosarcoma-a-case-report-and-literature-review
#9
Kyungjin Lee, Seong Hwan Kim, Soung-Min Kim, Hoon Myoung
Chondrosarcoma is a malignant tumor that originates from cartilaginous cells and is characterized by cartilage formation. Only 5% to 10% of chondrosarcoma occurs in the head and neck area, and it is uncommon in the temporomandibular joint area. This report describes an unusual case with a rare, large chondrosarcoma in a 47-year-old woman who presented with painless swelling and trismus. Computed tomography showed a large mass approximately 8.5×6.0 cm in size arising adjacent to the lateral pterygoid plate and condyle...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27835579/a-novel-benzofuran-derivative-acdb-induces-apoptosis-of-human-chondrosarcoma-cells-through-mitochondrial-dysfunction-and-endoplasmic-reticulum-stress
#10
Chen-Ming Su, Chien-Yu Chen, Tingting Lu, Yi Sun, Weimin Li, Yuan-Li Huang, Chun-Hao Tsai, Chih-Shiang Chang, Chih-Hsin Tang
Chondrosarcoma is one of the bone tumor with high mortality in respond to poor radiation and chemotherapy treatment. Here, we analyze the antitumor activity of a novel benzofuran derivative, 2-amino-3-(2-chlorophenyl)-6-(4-dimethylaminophenyl)benzofuran-4-yl acetate (ACDB), in human chondrosarcoma cells. ACDB increased the cell apoptosis of human chondrosarcomas without harm in chondrocytes. ACDB also enhanced endoplasmic reticulum (ER) stress, which was characterized by varieties in the cytosolic calcium levels and induced the expression of glucose-regulated protein (GRP) and calpain...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832806/diagnosis-of-extraskeletal-myxoid-chondrosarcoma-in-the-thigh-using-ewsr1-nr4a3-gene-fusion-a-case-report
#11
Hiroki Kobayashi, Kazutaka Kikuta, Tetsuya Sekita, Michiro Susa, Kazumasa Nishimoto, Aya Sasaki, Kaori Kameyama, Shintaro Sugita, Tadashi Hasegawa, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
BACKGROUND: Extraskeletal myxoid chondrosarcoma is a rare soft tissue sarcoma that has unusual ultrastructural and molecular features. However, unlike other soft tissue sarcomas, it does not have specific clinical symptoms or radiological features, which can make its diagnosis difficult. Nevertheless, extraskeletal myxoid chondrosarcoma has a rare gene fusion (EWSR1-NR4A3) that is useful for making a differential diagnosis. CASE PRESENTATION: A 43-year-old Japanese man presented with a soft tissue mass in his right thigh...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27826039/amphiregulin-enhances-vegf-a-production-in-human-chondrosarcoma-cells-and-promotes-angiogenesis-by-inhibiting-mir-206-via-fak-c-src-pkc%C3%AE-pathway
#12
Chao-Qun Wang, Yu-Wen Huang, Shih-Wei Wang, Yuan-Li Huang, Chun-Hao Tsai, Yong-Ming Zhao, Bi-Fei Huang, Guo-Hong Xu, Yi-Chin Fong, Chih-Hsin Tang
Chondrosarcoma is the second most common primary malignancy of bone after myeloma and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). The expression of VEGF-A has been recognized as a prognostic marker in angiogenesis. Amphiregulin (AR), an epidermal growth factor receptor ligand, promotes tumor proliferation, metastasis and angiogenesis. However, the role of AR in VEGF-A expression and angiogenesis in human chondrosarcoma remains largely unknown...
November 5, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27825689/safety-and-effectiveness-of-cadaveric-allograft-sternochondral-replacement-after-sternectomy-a-new-tool-for-the-reconstruction-of-anterior-chest-wall
#13
Giuseppe Marulli, Andrea Dell'amore, Francesca Calabrese, Marco Schiavon, Niccolò Daddi, Giampiero Dolci, Franco Stella, Federico Rea
BACKGROUND: Surgical excision with wide margins, prevention of respiratory impairment, and protection of surrounding organs are primary goals in resection and reconstruction of the chest wall. We describe our experience of the use of cadaveric cryopreserved sternal allograft. METHODS: Eighteen patients underwent surgery. Indications for sternectomy were sternal metastases (n = 9), primary chondrosarcoma (n = 4), sternal dehiscence (n = 2), soft tissue sarcoma (n = 1), malignant solitary fibrous tumor (n = 1), and direct involvement of thymic carcinoma (n = 1)...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27821242/-primary-ovarian-mesenchymal-chondrosarcoma-report-of-a-case
#14
Z Y Yue, D X Song, J Miao, H Wang, Y G Dong
No abstract text is available yet for this article.
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27819877/benefit-of-radiotherapy-in-extraskeletal-myxoid-chondrosarcoma-a-propensity-score-weighted-population-based-analysis-of-the-seer-database
#15
Eric J Kemmerer, Elizabeth Gleeson, Jaganmohan Poli, Robert T Ownbey, Luther W Brady, Wilbur B Bowne
OBJECTIVES: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignancy for which the role of radiotherapy is not well-defined. We examine the effect of external beam radiotherapy (EBRT) on cancer-specific survival (CSS) for patients with localized EMC, in a propensity score weighted, population-based analysis. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database (1973 to 2012) was queried for cases of localized EMC arising from soft connective tissues of the trunk and extremities treated with surgery and/or EBRT...
November 4, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27817079/retraction-note-to-downregulation-of-mir-185-and-upregulation-of-mir-218-expression-may-be-potential-diagnostic-and-prognostic-biomarkers-of-human-chondrosarcoma
#16
Peyman Karimi Goudarzi, Afshin Taheriazam, Saeid Asghari, Mohammad Jamshidi, Mohammadreza Shakeri, Emad Yahaghi, Alireza Mirghasemi
No abstract text is available yet for this article.
November 5, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27815598/in-vitro-chondrocyte-toxicity-following-long-term-high-dose-exposure-to-gd-dtpa-and-a-novel-cartilage-targeted-mr-contrast-agent
#17
Sharon Midura, Erika Schneider, Gerald M Rosen, Carl S Winalski, Ronald J Midura
OBJECTIVE: To determine the concentrations exhibiting toxicity of a cartilage-targeted magnetic resonance imaging contrast agent compared with gadopentetate dimeglumine (Gd-DT-PA) in chondrocyte cultures. MATERIALS AND METHODS: A long-term Swarm rat chondrosarcoma chondrocyte-like cell line was exposed for 48 h to 1.0-20 mM concentrations of diaminobutyl-linked nitroxide (DAB4-DLN) citrate, 1.0-20 mM Gd-DTPA, 1.0 μM staurosporine (positive control), or left untreated...
November 4, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27793401/near-infrared-intraoperative-molecular-imaging-can-locate-metastases-to-the-lung
#18
Jane Keating, Andrew Newton, Ollin Venegas, Sarah Nims, Ryan Zeh, Jarrod Predina, Charuhas Deshpande, John Kucharczuk, Shuming Nie, E James Delikatny, Sunil Singhal
BACKGROUND: Pulmonary metastasectomy is widely accepted for many tumor types because it may prolong survival and potentially cure some patients. However, intraoperative localization of pulmonary metastases can be technically challenging. We propose that intraoperative near-infrared (NIR) molecular imaging can be used as an adjunct during disease localization. METHODS: We inoculated 50 C57BL/6 mice with Lewis lung carcinoma (LLC) flank tumors. After flank tumor growth, mice were injected through the tail vein with indocyanine green (ICG) before operation, and intraoperative imaging was used to detect pulmonary metastases...
October 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27791830/contralateral-osteotomy-of-the-pedicle-and-posterolateral-elements-for-en-bloc-resection-a-technique-for-oncological-resection-of-posterolateral-spinal-tumors
#19
Viren S Vasudeva, Alexander E Ropper, Samuel Rodriguez, Kyle C Wu, John H Chi
En bloc resection of tumors involving the spinal column is technically challenging and is associated with high morbidity to the patient due to the proximity of critical neurological and vascular structures and the destabilizing nature of this surgery. Nevertheless, evidence has shown improved progression-free survival with en bloc resection for certain low-grade malignant and aggressive benign musculoskeletal tumors. To avoid the morbidity of en bloc spondylectomy in patients with tumors localized to the lateral and posterolateral spinal column, the authors have found that the goals of surgery can be accomplished through a contralateral osteotomy of the pedicle and posterolateral elements for en bloc resection (COPPER)...
October 28, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27790706/clinical-outcomes-for-patients-after-surgery-and-radiation-therapy-for-mesenchymal-chondrosarcomas
#20
Karen De Amorim Bernstein, Norbert Liebsch, Yen-Lin Chen, Andrzej Niemierko, Joseph H Schwab, Kevin Raskin, Santiago A Lozano-Calderon, Gregory Cote, David C Harmon, Edwin Choy, Alex Haynes, John Mullen, Francis J Hornicek, Thomas F DeLaney
INTRODUCTION: We report the outcome of 23 patients with mesenchymal chondrosarcomas treated with surgery and radiation therapy +/- chemotherapy. The intent of the project was to review the impact of patient and treatment variables on treatment outcome, in particular with regard to extent of surgery and radiation dose. PATIENTS AND METHODS: Twenty-three patients with mesenchymal chondrosarcomas were treated with surgery and radiation therapy (min. dose 44 Gy; max...
October 28, 2016: Journal of Surgical Oncology
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