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Chondrosarcoma

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https://www.readbyqxmd.com/read/28733066/effective-use-of-levosimendan-in-anthracycline-induced-cardiomyopathy-a-case-report
#1
Nikolaos Miaris, Stefanos Zezas, Joseph Sgouros, Dimitra-Christina Zirou, Stefania Gkoura, George Stamoulis, Helen Angelopoulou, George Avgeropoulos, Epaminondas Samantas
BACKGROUND: Anthracycline-induced cardiomyopathy is a serious side effect that ranges from mild left ventricular systolic impairment to congestive heart failure and cardiogenic shock. Currently, there is no evidence indicating the effective use of levosimendan in these cases. OBJECTIVE: We aim to present a case of life-threatening doxorubicin-induced cardiomyopathy that was successfully managed with levosimendan. CASE: A 48-year-old female with formerly normal heart function, who had been treated with doxorubicin-based regimens for dedifferentiated chondrosarcoma, presented with cardiomyopathy with low left ventricular ejection fraction eight months after the last infusion...
July 18, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28728303/-enhancing-soft-tissue-reattachment-with-artificial-mesh-in-joint-endoprosthetic-reconstruction-for-bone-tumors
#2
J S Lin, R Chen, W Yan, D D Chen
Objective: To investigate the operative method and clinical application of the BARD(®) Mesh in enhancing joint stability and function of endoprosthetic reconstruction for bone tumors. Methods: From Jan 2013 to Jun 2015, the clinical data of 51 patients aged (44.75±23.18) years underwent wide resection of tumor and endoprosthetic reconstruction using the BARD(®) Mesh were collected. Among them, 27 were male and 24 were female. The surgical treatments received by these patients included 5 shoulder arthroplasties, 12 elbow replacements, 12 hip replacements and 32 knee replacements (including 24 femoral tumors and 8 tibial tumors)...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28723616/prognostic-value-of-programmed-death-ligand-1-in-sarcoma-a-meta-analysis
#3
Zhenhua Zhu, Zheng Jin, Mei Zhang, Yajun Tang, Guang Yang, Xiaowei Yuan, Jihang Yao, Dahui Sun
BACKGROUND: The prognostic role of programmed death-ligand 1 (PD-L1) in sarcoma remains controversial. We performed a meta-analysis so as to investigate the impact of PD-L1 on clinicopathlogical findings and survival outcomes in sarcoma. MATERIALS AND METHODS: A comprehensive search in PubMed, Embase and the Cochrane Library was conducted for relevant studies. The odds ratios or hazard ratios, at 95% confidence intervals were used as measures for investigation of the correlation between PD-L1 expression and clinicopathlogical features or survival outcomes...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721303/value-of-99m-tc-mdp-spect-ct-and-18-f-fdg-pet-ct-scanning-in-the-evaluation-of-malignantly-transformed-fibrous-dysplasia
#4
Wei-Jun Wei, Zhen-Kui Sun, Chen-Tian Shen, Xin-Yun Zhang, Juan Tang, Hong-Jun Song, Zhong-Ling Qiu, Quan-Yong Luo
Although fibrous dysplasia is not considered a potentially premalignant disorder, malignant transformation occurs. Because of its rarity, radiographic features of malignantly transformed fibrous dysplasia on cross-sectional imaging modalities are less recognized, making diagnosis and differential diagnosis of the disease quite difficult in clinical practice. In this study, we analyzed the clinical characteristics, imaging features, pathology findings and surgery strategies of 19 malignantly transformed fibrous dysplasia...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28720081/identification-of-an-easy-to-use-3d-culture-model-to-investigate-invasion-and-anticancer-drug-response-in-chondrosarcomas
#5
Eva Lhuissier, Céline Bazille, Juliette Aury-Landas, Nicolas Girard, Julien Pontin, Martine Boittin, Karim Boumediene, Catherine Baugé
BACKGROUND: Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from that of three-dimensional (3D) one. In the present study, an in vitro tumor tissue model was constructed using alginate hydrogel, and in vitro cytotoxic efficacy of two anticancer drugs (cisplatin and DZNep) was investigated in chondrosarcomas, and compared to in vivo response. METHODS: Three cell lines derived from human chondrosarcomas, CH2879, JJ012 and SW1353, were embedded in alginate hydrogel...
July 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28717079/severe-hypocalcemia-in-a-patient-with-recurrent-chondrosarcoma
#6
Jung Nam Eun, Yoo Duk Choi, Jeong Ho Lee, Yun Ah Jeong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
Hypocalcemia is relatively uncommon paraneoplastic syndrome. Only one case of hypocalcemia has been reported in a patient with chondrosarcoma. We herein report a case of a 32-year-old woman with metastatic chondrosarcoma with tetany. Her imaging findings revealed multiple calcific metastatic lesions in the lungs, pancreas, left atrium, and pulmonary vein. A laboratory examination showed hypocalcemia with no evidence of any other disease that could induce hypocalcemia. On the basis of the laboratory and clinical findings, we concluded the etiology of her severe hypocalcemia to be excessive calcium consumption by the tumor itself...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28709860/chondrosarcoma-extrinsic-compression-of-the-right-ventricle-and-pericardial-effusion
#7
Pablo Robles Velasco, Isabel Monedero Sánchez
No abstract text is available yet for this article.
July 11, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28707014/doxycycline-and-its-quaternary-ammonium-derivative-for-adjuvant-therapies-of-chondrosarcoma
#8
Imen Miladi, Magali Vivier, Marie-Mélanie Dauplat, Morgane Chatard, Sophie Besse, Aurélien Vidal, Karine Chassain, Betty Jean, Christiane Forestier, Jean-Michel Chezal, Francoise Rédini, Francoise Degoul, Elisabeth Miot-Noirault
PURPOSE: This study was conducted during the development of innovative treatment targeting the microenvironment of chondrosarcoma. In this context, MMP inhibitors were conjugated with a quaternary ammonium (QA) function as a targeting ligand to proteoglycans of chondrosarcoma extracellular matrix. Here we report the proof of concept of this strategy applied to the MMP13 inhibitor, doxycycline (Dox). METHODS: A quaternary ammonium derivative of the MMP13 inhibitor doxycycline (QA-Dox) was synthesized, and its anticancer activity was evaluated in the Swarm rat chondrosarcoma (SRC) model compared with the parent drug doxycycline, in vitro and in vivo...
July 13, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28706394/proximal-epithelioid-sarcomatous-dedifferentiation-in-secondary-chondrosarcoma-in-a-known-case-of-multiple-osteochondromatosis
#9
Biswajit Dey, Mangesh Chikhale, Prita Pradhan, Adarsh Barwad, Bhawana Ashok Badhe
Osteochondroma is the most common benign bone tumor. Approximately 15% of osteochondromas occur as multiple lesions. Multiple osteochondromatosis has a higher risk of developing chondrosarcomas, which are of low grade with good prognosis. About 10% of all chondrosarcomas may undergo dedifferentiated change, which has a poorer prognosis. Dedifferentiated peripheral chondrosarcoma developing within an osteochondroma is extremely rare. Dedifferentiation usually occurs in the form of osteosarcoma, malignant fibrous histiocytoma, fibrosarcoma, or rhabdomyosarcoma...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28704566/development-and-characterization-of-a-human-three-dimensional-chondrosarcoma-culture-for-in-vitro-drug-testing
#10
Aurélien Voissiere, Elodie Jouberton, Elise Maubert, Françoise Degoul, Caroline Peyrode, Jean-Michel Chezal, Élisabeth Miot-Noirault
It has been suggested that chemoresistance of chondrosarcoma (CHS), the cartilage tumor, is caused by the phenotypic microenvironmental features of the tumor tissue, mainly the chondrogenic extracellular matrix (ECM), and hypoxia. We developed and characterized a multicellular tumor spheroid (MCTS) of human chondrosarcoma HEMC-SS cells to gain insight into tumor cell biology and drug response. At Day 7, HEMC-SS spheroids exhibited a homogeneous distribution of proliferative Ki-67 positive cells, whereas in larger spheroids (Day 14 and Day 20), proliferation was mainly localized in the periphery...
2017: PloS One
https://www.readbyqxmd.com/read/28698435/-histology-specific-chemotherapy-in-soft-tissue-sarcomas
#11
Eisuke Kobayashi, Akira Kawai
Soft-tissue sarcomas(STSs)are rare mesenchymal tumors, accounting for less than 1%of all adult malignancies. STSs also have diversity, with more than 50 different histological subtypes. While surgical complete resection is a definitive treatment for localized STS, chemotherapy is the treatment option for managing locally advanced and metastatic STS. Although doxorubicin ±ifosfamide is still the first-line therapy for most STS subtypes, some STSs(alveolar soft part sarcoma, clear cell sarcoma, epithelioid sarcoma and extraskeletal myxoid chondrosarcoma)have been reported to have little response to these cytotoxic chemotherapies...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28695356/what-are-the-differentiating-clinical-and-mri-features-of-enchondromas-from-low-grade-chondrosarcomas
#12
Hassan Douis, M Parry, S Vaiyapuri, A M Davies
OBJECTIVES: To evaluate the role of clinical assessment, conventional and dynamic contrast-enhanced MRI in differentiating enchondromas from chondrosarcomas of long bone. METHODS: The following clinical and MRI findings were assessed: age, gender, pain, pain attributable to lesion, tumour location, tumour length, presence, depth of endosteal scalloping, bone marrow oedema, soft tissue oedema, cortical destruction, periosteal reaction, bone expansion, macroscopic fat, calcification, soft tissue mass, haemorrhage, dynamic contrast-enhanced MRI...
July 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28691010/management-of-chordoma-and-chondrosarcoma-with-fractionated-stereotactic-radiotherapy
#13
Harish N Vasudevan, David R Raleigh, Julian Johnson, Adam A Garsa, Philip V Theodosopoulos, Manish K Aghi, Christopher Ames, Michael W McDermott, Igor J Barani, Steve E Braunstein
OBJECTIVE: To evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) for chordoma and chondrosarcoma. METHODS: Twenty consecutive patients with a histopathologic diagnosis of chordoma (n = 16) or chondrosarcoma (n = 4) treated between 2010 and 2016 were retrospectively identified. All patients underwent FSRT in five fractions to a median dose of 37.5 Gy (range: 25-40 Gy) and followed with serial magnetic resonance imaging...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28690520/extraskeletal-chondroma-of-the-index-finger-a-case-report
#14
Masato Saito, Kazumasa Nishimoto, Robert Nakayama, Kazutaka Kikuta, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
Extraskeletal chondroma is defined as a rare, benign, cartilaginous tumor arising from soft tissues such as tendons, tendon sheath synovia, and joint capsules with no continuity to the periosteum or bone cortex. In histopathologic findings, the tumor exhibits many lobular structures and some parts similar to hyaline cartilage. Therefore, it is sometimes difficult to differentiate this tumor from low-grade chondrosarcoma because of their similar histopathologic findings. In order to prevent recurrence, it is necessary to remove the tumor as a whole, including the capsule, so as not to leave any remnants of the tumor...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28688724/pd-1-and-pd-l1-expression-in-bone-and-soft-tissue-sarcomas
#15
Alireza Torabi, Clarissa N Amaya, Frank H Wians, Brad A Bryan
PD-1 and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the Unites States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell lung carcinoma and recently expanded the use of immunotherapy for metastatic urothelial cell carcinoma and Hodgkin lymphoma. However, studies on expression of PD-1 and its ligand in malignant bone and soft tissue sarcoma are sparse. In this study, we evaluated PD-1 and PD-L1 expression on variants of liposarcomas and rhabdomyosarcomas, osteosarcomas and chondrosarcomas...
August 2017: Pathology
https://www.readbyqxmd.com/read/28686110/role-of-endoscopic-transnasal-surgery-for-skull-base-chondrosarcoma-a-retrospective-analysis-of-19-cases-at-a-single-institution
#16
Hirotaka Hasegawa, Masahiro Shin, Kenji Kondo, Shunya Hanakita, Akitake Mukasa, Taichi Kin, Nobuhito Saito
OBJECTIVE Skull base chondrosarcoma is one of the most intractable tumors because of its aggressive biological behavior and involvement of the internal carotid artery and cranial nerves (CNs). One of the most accepted treatment strategies for skull base chondrosarcoma has been surgical removal of the tumor in conjunction with proactive extensive radiation therapy (RT) to the original tumor bed. However, the optimal strategy has not been determined. The goal of this study was to evaluate the early results of endoscopic transnasal surgery (ETS)...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28684229/reverse-shoulder-endoprosthesis-for-pathologic-lesions-of-the-proximal-humerus-a-minimum-3-year-follow-up
#17
Simon Maclean, Shahbaz S Malik, Scott Evans, Jonathan Gregory, Lee Jeys
BACKGROUND: The Bayley Walker (Stanmore Implants, Elstree, UK) reversed polarity, linked shoulder replacement is designed to provide stable function in the treatment of a painful shoulder with poor soft tissue coverage. We reviewed the results of the prosthesis in destructive pathologic lesions of the proximal humerus at a United Kingdom tumor center. METHODS: We identified 8 patients (2 men, 6 women) in our database. Clinical information and functional outcome scores were collected, including range of movement, Toronto Extremity Salvage Score, the Musculoskeletal Tumor Score...
July 3, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28673141/a-case-of-chondrosarcoma-originating-from-the-pulmonary-artery
#18
Kenji Sakakibara, Hiroyuki Nakajima, Kazunari Kasai
No abstract text is available yet for this article.
June 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28672103/shingosine-1-phosphate-suppresses-chondrosarcoma-metastasis-by-up-regulation-of-tissue-inhibitor-of-metalloproteinase-3-through-suppressing-mir-101-expression
#19
Chun-Hao Tsai, Dong-Ying Yang, Chih-Yang Lin, Tsung-Ming Chen, Chih-Hsin Tang, Yuan-Li Huang
Chondrosarcoma is the second most common primary malignancy form of bone cancer, exhibiting resistance to chemotherapy and radiation therapy as well as developing high metastasis ability in late stage tumors. Thus, understanding the metastatic processes of chondrosarcoma is considered a strategy for treatment of this disease. Sphingosine 1-phosphate (S1P), a bioactive sphingolipid, is produced intracellularly by sphingosine kinase (SphK) and is regarded as a second signaling molecule that regulates inflammation, proliferation, angiogenesis, and metastasis...
July 3, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28666625/is-intralesional-resection-suitable-for-central-grade-1-chondrosarcoma-a-systematic-review-and-updated-meta-analysis
#20
X Chen, L J Yu, H M Peng, C Jiang, C H Ye, S B Zhu, W W Qian
BACKGROUND: The surgical choice for grade 1 chondrosarcoma has been debated for decades. Intralesional resection can minimize the damage caused by surgery and offer better functional outcome. However, controversy remains about whether it will result in higher rates of local recurrence and metastasis, fewer complications, and better functional outcome compared with resection with wide margin. This systematic review and updated meta-analysis therefore compared intralesional resection and resection with wide margin in terms of local recurrence, metastasis, complications, and functional outcome...
June 14, 2017: European Journal of Surgical Oncology
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