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Adiposity and meningioma

Ziming Du, Ryan Brewster, Parker H Merrill, Juliann Chmielecki, Josh Francis, Ayal Aizer, Malak Abedalthagafi, Lynette M Sholl, Lars Geffers, Brian Alexander, Sandro Santagata
Background: Tumor cells recapitulate cell-lineage transcriptional programs that are characteristic of normal tissues from which they arise. It is unclear why such lineage programs are fatefully maintained in tumors and if they contribute to cell proliferation and viability. Methods: Here, we used the most common brain tumor, meningioma, which is strongly associated with female gender and high body mass index (BMI), as a model system to address these questions. We screened expression profiling data to identify the transcription factor (TF) genes which are highly enriched in meningioma, and characterized the expression pattern of those TFs and downstream genes in clinical meningioma samples as well as normal brain tissues...
April 12, 2018: Neuro-oncology
Emily Lenczowski, Morgan L Wilson
No abstract text is available yet for this article.
May 2018: Journal of Cutaneous Pathology
Graham A Colditz, Lindsay L Peterson
BACKGROUND: Mounting evidence, particularly from prospective epidemiologic studies but with additional support from animal models and mechanistic studies, supported conclusions in 2016 by the International Agency for Research on Cancer (IARC) in their review of the preventive effects of weight control on cancer risk. CONTENT: The workgroup concluded that obesity is causally related to cancer at 13 anatomic sites (esophagus: adenocarcinoma; gastric cardia; colon and rectum; liver; gallbladder; pancreas; breast: postmenopausal; uterine endometrial; ovary; kidney: renal cell; meningioma; thyroid; and multiple myeloma)...
January 2018: Clinical Chemistry
Chibuike Enwereuzo, Luis Moral, Jean M Henneberry
Meningioma is a neoplasm of the meninges, which usually occurs in intracranial sites. Extracranial meningioma has been frequently reported in the sinonasal tract and skull bone, often as extension of intracranial meningiomas. Isolated heterotopic meningioma without contiguous intracranial lesion is extremely rare. A 56-year-old woman presented in December 2015 with 2 firm subcutaneous scalp masses; one in the left lateral (temporal) and the other in the left superior (parietal) region. The clinical impression was that of lipoma...
April 2018: American Journal of Dermatopathology
Tuomo Thesleff, Kai Lehtimäki, Tero Niskakangas, Sanna Huovinen, Bettina Mannerström, Susanna Miettinen, Riitta Seppänen-Kaijansinkko, Juha Öhman
Several alternative techniques exist to reconstruct skull defects. The complication rate of the cranioplasty procedure is high and the search for optimal materials and techniques continues. To report long-term results of patients who have received a cranioplasty using autologous adipose-derived stem cells (ASCs) seeded on beta-tricalcium phosphate (betaTCP) granules. Between 10/2008 and 3/2010, five cranioplasties were performed (four females, one male; average age 62.0 years) using ASCs, betaTCP granules and titanium or resorbable meshes...
July 2017: Stem Cells Translational Medicine
Melina Arnold, Andrew G Renehan, Graham A Colditz
No abstract text is available yet for this article.
May 2017: Cancer Epidemiology, Biomarkers & Prevention
Corinna Seliger, Christoph R Meier, Claudia Becker, Susan S Jick, Martin Proescholdt, Ulrich Bogdahn, Peter Hau, Michael F Leitzmann
BACKGROUND: Meningioma is a frequent primary intracranial tumor, the etiology of which is potentially related to adiposity. Metabolic syndrome (MetS) is an increasingly common disease characterized by having at least three of the following conditions: central adiposity, arterial hypertension, dyslipidemia, and insulin resistance. Only one prior study investigated MetS in relation to meningioma risk and found a positive association between the two. RESULTS: Among 2,027 cases and 20,269 controls, body mass index was positively associated with meningioma (p-value for trend < 0...
January 10, 2017: Oncotarget
Tobias Niedermaier, Gundula Behrens, Daniela Schmid, Inga Schlecht, Beate Fischer, Michael F Leitzmann
OBJECTIVE: Whether adiposity and lack of physical activity affect the risk for developing meningioma and glioma is poorly understood. Our objective was to characterize these associations in detail. METHODS: We conducted a systematic review and meta-analysis of adiposity and physical activity in relation to meningioma and glioma using cohort and case-control studies published through February 2015. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
October 13, 2015: Neurology
Weiqiang Tang, Yan Hei, Lihua Xiao
OBJECTIVE: To analyze the clinical features, histopathologic classification and frequencies of various types of recurrent orbital space-occupying lesions. METHODS: A retrospective study was carried out in 253 consecutive patients with recurrent orbital space-occupying lesions treated by surgical excision in the Institute of Orbital Diseases, the General Hospital of the Armed Police Force from January 2009 to December 2010. RESULTS: The patients included 123 males and 130 females aged 2 to 78 years (mean, 36...
August 2013: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Joni K Doherty, Fred H Linthicum
No abstract text is available yet for this article.
February 2013: Otology & Neurotology
Vasily A Cherekaev, Denis A Golbin, Alexander I Belov
BACKGROUND: Problem of closure of skull base defects after removal of craniobasal lesions, especially, craniofacial, is one of the most challenging in neurosurgery. Persistent skull base defect produces extremely high risk of cerebrospinal fluid leaks and consecutive infectious complications. Local pedicled grafts are the preferred material for plasty. In this study, the authors present original technique of using a pedicled buccal fat pad (BFP) graft. Anatomy and functions of BFP are discussed in details as well as surgical technique illustrated by 2 case reports...
January 2012: Journal of Craniofacial Surgery
Ahmed Nageeb M Taha, Rami Almefty, Svetlana Pravdenkova, Ossama Al-Mefty
BACKGROUND: The use of an autologous free fat graft is a widely applied technique to obliterate dead space and reinforce dural closure during skull base reconstructions. The associated complications and outcomes of this practice have not been studied. Dissemination of fat in the subarachnoid space resulting in lipoid meningitis has been reported after translabyrinthine approaches, and leakage of liquefied fat is seldom reported in the literature. This study aims to evaluate the morbidity associated with the usage of autologous fat graft in reconstruction of skull base defects based on an extensive experience...
May 2011: World Neurosurgery
Klaus Weber, Robert H Garman, Paul-Georg Germann, Jerry F Hardisty, Georg Krinke, Peter Millar, Ingrid D Pardo
Neoplasms of the nervous system, whether spontaneous or induced, are infrequent in laboratory rodents and very rare in other laboratory animal species. The morphology of neural tumors depends on the intrinsic functions and properties of the cell type, the interactions between the neoplasm and surrounding normal tissue, and regressive changes. The incidence of neural neoplasms varies with sex, location, and age of tumor onset. Although the onset of spontaneous tumor development cannot be established in routine oncogenicity studies, calculations using the time of diagnosis (day of death) have revealed significant differences in tumor biology among different rat strains...
January 2011: Toxicologic Pathology
Hilary L Somerset, B K Kleinschmidt-DeMasters, David Rubinstein, R E Breeze
Intracranial chondromas are uncommon benign lesions usually attached to dura and located over the convexity of the skull. Osteochondromas are even rarer and additionally contain a benign bony component. Both lesions are reportedly difficult to distinguish from meningiomas on pre-operative neuroimaging studies, although few detailed pathologic-neuroimaging correlation studies have appeared in the literature, particularly for intracranial osteochondromas. A 33-year-old woman with a 4-year history of headaches presented with recent onset of left-sided muscle spasms and weakness...
July 2010: Journal of Neuro-oncology
Irit Hochberg, Ze'ev Hochberg
Following extensive suprasellar operations for excision of hypothalamic tumors, some patients develop morbid obesity, the so-called hypothalamic obesity (HyOb). HyOb complicates disorders related to the hypothalamus, including those that cause structural damage to the hypothalamus, pituitary macroadenoma with suprasellar extension, glioma, meningioma, teratoma, germ cell tumors, radiotherapy, Prader-Willi syndrome, and mutations in leptin, leptin receptor, POMC, MC4R and CART genes. It is conceivable that a subgroup of patients with 'simple obesity' also have HyOb...
2010: Endocrine Development
Kenny Yu, James Van Dellen, Philip Idaewor, Federico Roncaroli
OBJECTIVE: We describe an intraosseous angiolipoma of the cranium and discuss the outcome. Angiolipomas are benign tumors that consist of mature adipose tissue and abnormal vessels. They occur predominantly in the subcutaneous tissue of the trunk and upper limbs. Only 4 examples of intraosseous angiolipomas have been reported in the literature, all of which involved the mandible and ribs. CLINICAL PRESENTATION: A 39-year-old man presented with a right parietal swelling...
January 2009: Neurosurgery
Hiroshi Kashimura, Hiroshi Arai, Kuniaki Ogasawara, Takaaki Beppu, Akira Kurose, Akira Ogawa
A 55-year-old man presented with a rare lipomatous meningioma associated with acute subdural hematoma manifesting as sudden onset of severe headache, but no neurological deficit. No evidence of trauma or underlying predisposition to hemorrhage was seen. Fluid-attenuated inversion-recovery magnetic resonance imaging showed a thin hyperintense area in the right temporal convexity, and an extra-axial mass appearing as mixed hypointensity and hyperintensity. Two weeks later, right temporal craniotomy was performed and the tumor was totally resected with the attached dura...
October 2008: Neurologia Medico-chirurgica
M A Reina, P Pulido, J Castedo, M C Villanueva, A López, J A De Andrés, R G Sola
Epidural fat is a reservoir of lipophilic substances that cushions the pulsatile movements of the dural sac, protects nerve structures, and facilitates the movement of the dural sac over the periosteum of the spinal canal during flexion and extension. Excessive epidural fat can compress the underlying structures, however, and affect the placement of catheters and the distribution of injected solutions. This review discusses changes in epidural fat related to various diseases and events: lipomatosis, epidural lymphoma, arachnoid cysts, epidural hematoma, meningiomas, angiolipomas, spondylolysis, scoliosis, spinal stenosis, and liposarcoma...
March 2007: Revista Española de Anestesiología y Reanimación
Taoufiq Harmouch, Magali Colombat, Aida El Amri, Antoine Feydy, Michel Kalamarides, Aimée Redondo, Claude Degott
Lipomatous meningiomas are rarely encountered and are included in the World Health Organization's (WHO) group of metaplastic meningiomas. We report two cases of these tumors. The presenting symptoms were headaches in one case and seizure in the other. Radiologically, these tumors were extra-axial and unique. One tumor displayed fat accumulation, while the other had the appearance of a conventional meningioma. Microscopically, these tumors corresponded to meningothelial and transitional meningiomas containing a variable proportion of adipose tissue composed of mature adipocytes or lipoblasts...
October 2005: Annales de Pathologie
E Matyja, E Naganska, M Zabek, J Jagielski
Meningiomas exhibit a broad spectrum of differentiation potency corresponding to different histological subtypes. The separate secretory or lipomatous transformation of meningothelial cells is uncommonly encountered in meningiomas classified into distinct secretory or lipomatous variants. The coexistence of these two different histological subtypes is extremely rare. We report an exceptional case of secretory meningioma associated with extensive lipomatous component in a 58-year-old woman. CT scan and MRI of the brain showed a well-defined tumor mass in the right temporal lobe with areas of adipose tissue and extensive surrounding brain edema...
November 2005: Clinical Neuropathology
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