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micronucleus biomarkers obesity

Nishu Sekar, Manju Nair, Glory Francis, Parvathy Raj Kongath, Sandhya Babu, Sudhakaran Raja, Abilash Valsala Gopalakrishnan
BACKGROUND: The polycystic ovary syndrome (PCOS), characterized by hyperandrogenism and chronic anovulation, is a common endocrine disorder in women. PCOS, which is associated with polycystic ovaries, hirsutism, obesity and insulin resistance, is a leading cause of female infertility. In this condition there is an imbalance in female sex hormones. All the sequelae symptoms of PCOS gradually lead to cancer in the course of time. It is heterogeneous disorder of unknown etiology so it is essential to find the exact cause...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Elisabeth Müllner, Helmut Brath, Armen Nersesyan, Marlies Nitz, Alice Petschnig, Marlies Wallner, Siegfried Knasmüller, Karl-Heinz Wagner
This study aimed to compare the frequencies of nuclear anomalies in buccal cells between diabetic and non-diabetic individuals and to assess the impact of a 'healthy diet'-a cornerstone in the treatment of diabetes. Seventy-six diabetic and 21 non-diabetic individuals participated in this parallel, randomised, intervention trial. All participants received information about the importance of a healthy diet, while participants randomly assigned to the intervention group received additionally 300g of vegetables and 25ml of plant oil rich in polyunsaturated fatty acids (PUFA) per day for 8 weeks...
January 2014: Mutagenesis
Maria Grazia Andreassi, Roberto Barale, Patricia Iozzo, Eugenio Picano
Obesity and metabolic syndrome (MetS) are serious and growing health care problems worldwide, leading an increased risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). Over the past decade, emerging evidence has shown that an increased chromosomal damage, as determined by the cytokinesis-block micronucleus (CBMN) assay, is correlated to the pathogenesis of metabolic and CVD. An increased micronuclei (MN) frequency has been demonstrated in peripheral blood lymphocytes of patients with polycystic ovary syndrome, a common condition in reproductive-aged women associated with impaired glucose tolerance, T2D mellitus and the MetS...
January 2011: Mutagenesis
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