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https://www.readbyqxmd.com/read/28644630/expanding-the-therapeutic-potential-of-the-iron-chelator-deferasirox-in-the-development-of-aqueous-stable-ti-iv-anticancer-complexes
#1
Sergio A Loza-Rosas, Alexandra M Vázquez-Salgado, Kennett I Rivero, Lenny J Negrón, Yamixa Delgado, Josué A Benjamín-Rivera, Angel L Vázquez-Maldonado, Timothy B Parks, Charlene Munet-Colón, Arthur D Tinoco
The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells. Deferasirox, a drug used for iron overload disease, is a cTfm ligand that models STf coordination to Fe(III), favoring Fe(III) binding versus Ti(IV)...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28643881/virucides-in-apiculture-persistence-of-surrogate-enterovirus-under-simulated-field-conditions
#2
Jana Prodělalová, Hana Malenovská, Romana Moutelíková, Dalibor Titěra
BACKGROUND: Honeybee viruses were recognized among the most important factors leading to colony losses worldwide. Colony food and faeces were regarded as possible source of infectious viruses able to contaminate environment and equipment of apiaries. Thus, methods for elimination of viruses are required. No cell culture assay for testing the effect of disinfectants on honeybee viruses is available yet. Therefore, surrogate virus was employed for testing of iodophor- and peracetic acid-based disinfectants efficacy in combination with six organic contaminants at +6 °C and +22 °C...
June 23, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28630706/effects-of-feeding-untreated-pasteurized-and-acidified-waste-milk-and-bunk-tank-milk-on-the-performance-serum-metabolic-profiles-immunity-and-intestinal-development-in-holstein-calves
#3
Yang Zou, Yajing Wang, Youfei Deng, Zhijun Cao, Shengli Li, Jiufeng Wang
BACKGROUND: The present experiment was performed to assess the effects of different sources of milk on the growth performance, serum metabolism, immunity, and intestinal development of calves. Eighty-four Holstein male neonatal calves were assigned to one of the following four treatment groups: those that received bunk tank milk (BTM), untreated waste milk (UWM), pasteurized waste milk (PWM), and acidified waste milk (AWM) for 21 d. RESULTS: Calves in the BTM and AWM groups consumed more starter (P < 0...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28607507/urinary-lipidomics-evidence-for-multiple-sources-and-sexual-dimorphism-in-healthy-individuals
#4
J Graessler, C S Mehnert, K-M Schulte, S Bergmann, S Strauss, T D Bornstein, J Licinio, M-L Wong, A L Birkenfeld, S R Bornstein
Urinary lipidomics may add new valuable biomarkers to the diagnostic armamentarium for early detection of metabolic and kidney diseases. Sources and composition of urinary lipids in healthy individuals, however, have not been investigated in detail. Shotgun lipidomics was used to quantify lipidomic profiles in native urine samples from 16 individuals (eight men, eight women) collected in five fractions over 24 h. All probands were comprehensively characterized by urinary and clinical indices. The mean total urinary lipid concentration per sample was 0...
June 13, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28603877/effects-of-moringa%C3%A2-oleifera-leaves-as-a-substitute-for-alfalfa-meal-on-nutrient-digestibility-growth-performance-carcass-trait-meat-quality-antioxidant-capacity-and-biochemical-parameters-of-rabbits
#5
B Sun, Y Zhang, M Ding, Q Xi, G Liu, Y Li, D Liu, X Chen
This contribution reports the effects of Moringa oleifera leaves (MOLs) meal on the growth performances, nutrient digestibility, carcass trait, meat quality, antioxidant capacity and biochemical parameters of growing New Zealand white rabbits. The MOL was substituted for alfalfa meal at levels of 0, 10%, 20% and 30% to obtain respective diets MOL0, MOL10, MOL20 and MOL30. Each treatment was replicated five times with 10 rabbits per replicate. Results showed the average daily weight gain (ADWG) and feed conversion ratio (FCR) of rabbits fed MOL20 diet were significantly better (p < 0...
June 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28597189/a-podocyte-view-of-membranous-nephropathy-from-heymann-nephritis-to-the-childhood-human-disease
#6
REVIEW
Pierre Ronco, Hanna Debiec
Membranous nephropathy (MN) is characterized by an accumulation of immune deposits on the subepithelial side of the glomerular basement membrane, which results in complement activation and proteinuria. Since 2002, several major antigens of the podocyte have been identified in human MN, the first one being neutral endopeptidase (NEP), the alloantigen involved in neonatal cases of MN that occur in newborns from NEP-deficient mothers. This discovery opened the field to the major advances that have occurred since then in the pathophysiology and treatment of MN...
June 8, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28594924/multiple-extracellular-vesicle-types-in-peritoneal-dialysis-effluent-are-prominent-and-contain-known-biomarkers
#7
Lachlan James Pearson, I-Yanut Klaharn, Bussakorn Thongsawang, Wasin Manuprasert, Thunvarat Saejew, Poorichaya Somparn, Piyatida Chuengsaman, Talerngsak Kanjanabuch, Trairak Pisitkun
Peritoneal dialysis inevitability results in activation of inflammatory processes and its efficiency is highly variable between patients. An improved method to isolate biomarkers and study pathophysiological mechanisms in peritoneal dialysis effluent (PDE) is expected to be of much benefit for the development of this treatment approach and help with patient management. Extracellular vesicles (EVs) are released as part of normal cellular processes. Their proteome is expected to reflect both type and health of their cell of origin...
2017: PloS One
https://www.readbyqxmd.com/read/28587287/a-routine-top-down-approach-to-analysis-of-the-human-serum-proteome
#8
Arlene M D'Silva, Jon A Hyett, Jens R Coorssen
Serum provides a rich source of potential biomarker proteoforms. One of the major obstacles in analysing serum proteomes is detecting lower abundance proteins owing to the presence of hyper-abundant species (e.g., serum albumin and immunoglobulins). Although depletion methods have been used to address this, these can lead to the concomitant removal of non-targeted protein species, and thus raise issues of specificity, reproducibility, and the capacity for meaningful quantitative analyses. Altering the native stoichiometry of the proteome components may thus yield a more complex series of issues than dealing directly with the inherent complexity of the sample...
June 6, 2017: Proteomes
https://www.readbyqxmd.com/read/28579938/the-connected-steady-state-model-and-the-interdependence-of-the-csf-proteome-and-csf-flow-characteristics
#9
Fabian Metzger, Daniel Mischek, Frédéric Stoffers
Here we show that the hydrodynamic radii-dependent entry of blood proteins into cerebrospinal fluid (CSF) can best be modeled with a diffusional system of consecutive interdependent steady states between barrier-restricted molecular flux and bulk flow of CSF. The connected steady state model fits precisely to experimental results and provides the theoretical backbone to calculate the in-vivo hydrodynamic radii of blood-derived proteins as well as individual barrier characteristics. As the experimental reference set we used a previously published large-scale patient cohort of CSF to serum quotient ratios of immunoglobulins in relation to the respective albumin quotients...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28571728/light-source-is-critical-to-induce-glioblastoma-cell-death-by-photodynamic-therapy-using-chloro-aluminiumphtalocyanine-albumin-based-nanoparticles
#10
Nathalia Nossi Davanzo, Diogo Silva Pellosi, Leonardo Pereira Franchi, Antônio Cláudio Tedesco
Selection of an efficient light source is fundamental in the development of photodynamic therapy (PDT) protocols. However, few studies provide a comparison of different light sources with regard to phototoxic effects. Here, we compared the cell death induced by photoactivation of chloro-aluminiumphtalocyanine (AlClPc)-loaded human serum albumin nanoparticles under irradiation with different light sources: continuous laser (CL), pulsed laser (PL), and light-emitting diode (LED). Cells were exposed to three different AlClPc concentrations (1, 3, and 5μM) and three different light doses (200, 500, and 700mJ/cm(2)) for each light source...
May 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28557353/generation-of-carbamoyl-phosphate-synthetase-1-reporter-cell-lines-for-the-assessment-of-ammonia-metabolism
#11
Yi Wang, Le Chang, Jiahui Zhai, Qiao Wu, Donggen Wang, Yunfang Wang
Both primary hepatocytes and stem cells-derived hepatocyte-like cells (HLCs) are major sources for bioartificial liver (BAL). Maintenance of hepatocellular functions and induction of functional maturity of HLCs are critical for BAL's support effect. It remains difficult to assess and improve detoxification functions inherent to hepatocytes, including ammonia clearance. Here, we aim to assess ammonia metabolism and identify ammonia detoxification enhancer by developing an imaging strategy. In hepatoma cell line HepG2, and immortalized hepatic cell line LO2, carbamoyl phosphate synthetase 1 (CPS1) gene, the first enzyme of ammonia-eliminating urea cycle, was labelled with fluorescence protein via CRISPR/Cas9 system...
May 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28538363/the-effect-of-alpha-linolenic-acid-on-glycemic-control-in-individuals-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#12
REVIEW
Elena Jovanovski, Dandan Li, Hoang Vi Thanh Ho, Vladimir Djedovic, Any de Castro Ruiz Marques, Esra Shishtar, Sonia Blanco Mejia, John L Sievenpiper, Russell J de Souza, Lea Duvnjak, Vladimir Vuksan
BACKGROUND: Polyunsaturated fats (PUFAs) have been shown to reduce type 2 diabetes (T2DM) risk and improve insulin responsiveness in T2DM subjects, but whether the plant sources of omega-3 PUFA (alpha-linolenic acid [ALA]) have an effect on glycemic control requires further investigation. METHODS: The parameters of interest were glycated hemoglobin (HbA1c), fasting blood glucose (FBG), fasting blood insulin (FBI), homeostatic model assessment for insulin resistance (HOMA-IR), fructosamine, and glycated albumin...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28536266/two-proteins-for-the-price-of-one-structural-studies-of-the-dual-destiny-preproalbumin-with-sunflower-trypsin-inhibitor-1
#13
Bastian Franke, Amy M James, Mehdi Mobli, Michelle L Colgrave, Joshua S Mylne, K Johan Rosengren
Seed storage proteins are both an important source of nutrition for humans and essential for seedling establishment. Interestingly, unusual napin-type 2S seed storage albumin precursors in sunflower contain a sequence that is released as a macrocyclic peptide during post-translational processing. The mechanism by which such peptides emerge from linear precursors proteins has received increased attention, however the structural characterization of intact precursor proteins has been limited. Here we report the 3D NMR structure of the Helianthus annuus PreproAlbumin With Sunflower trypsin inhibitor-1 (PawS1), and provide new insights into the processing of this remarkable dual-destiny protein...
May 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28501217/edta-functionalized-magnetic-nanoparticles-a-suitable-platform-for-the-analysis-of-low-abundance-urinary-proteins
#14
Paulo Bastos, Fábio Trindade, Rita Ferreira, Adelino Leite-Moreira, Inês Falcão-Pires, Bruno Manadas, Ana L Daniel-da-Silva, Rui Vitorino
Urine is a highly attractive source of biological information and disease biomarkers, whose proteome characterization is ongoing. To that end, depletion/enrichment strategies for protein analysis can be of great convenience. We have thus developed a method based on the use of EDTA-functionalized magnetic nanoparticles (NPs@EDTA), to fractionate urine samples before liquid chromatography-mass spectrometry analysis and compared the identified proteins with those obtained from ultrafiltrated/unfractionated (UF) urine samples...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28493600/endurance-training-selectively-increases-hdl-bound-sphingosine-1-phosphate-in-the-plasma
#15
Monika Książek, Małgorzata Charmas, Andrzej Klusiewicz, Piotr Zabielski, Barbara Długołęcka, Adrian Chabowski, Marcin Baranowski
Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid that is found in relatively high concentration in human plasma. Erythrocytes, endothelial cells, and activated platelets are the main sources of circulating S1P. The majority of plasma S1P is transported bound to high-density lipoprotein (HDL) and albumin. In recent years HDL-bound S1P attracted much attention due to its cardioprotective and anti-atherogenic properties. We have previously found that endurance-trained athletes are characterized by higher plasma S1P concentration compared to untrained individuals...
May 11, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28493490/the-protective-effect-of-humic-rich-substances-on-atypical-aeromonas-salmonicida-subsp-salmonicida-infection-in-common-carp-cyprinus-carpio-l
#16
G Yamin, R Falk, R R Avtalion, N Shoshana, T Ofek, R Smirnov, G Rubenstein, J van Rijn
When challenged with atypical Aeromonas salmonicida subsp. salmonicida, exposure of the common carp (Cyprinus carpio L.) to different humic-rich compounds resulted in a significant reduction in infection rates. Specifically, in fish exposed to (i) humic-rich water and sludge from a recirculating system, (ii) a synthetic humic acid, and (iii) a Leonardite-derived humic-rich extract, infection rates were reduced to 14.9%, 17.0% and 18.8%, respectively, as compared to a 46.8% infection rate in the control treatment...
May 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28476156/nutritional-deficiencies-in-homeless-persons-with-problematic-drinking-a-systematic-review
#17
REVIEW
Sharea Ijaz, Joni Jackson, Helen Thorley, Katie Porter, Clare Fleming, Alison Richards, Adrian Bonner, Jelena Savović
BACKGROUND: A significant proportion of homeless people drink alcohol excessively and this can lead to malnutrition and consequent medical problems. The aim of this review was to assess the evidence on the range of nutritional deficiencies in the homeless problem-drinking populations. METHODS: We conducted a comprehensive search of nine scientific literature databases and 13 grey literature sources. We included studies of any design that included homeless population with problem-drinking and reported measures of nutritional deficiencies in urine or blood...
May 5, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28474540/generation-of-canine-induced-extraembryonic-endoderm-like-cell-line-that-forms-both-extraembryonic-and-embryonic-endoderm-derivatives
#18
Toshiya Nishimura, Naoya Unezaki, Ryoji Kanegi, Daluthgamage Patsy Himali Wijesekera, Shingo Hatoya, Kikuya Sugiura, Noritoshi Kawate, Hiromichi Tamada, Hiroshi Imai, Toshio Inaba
Extraembryonic endoderm (XEN) cells are stem cell lines derived from primitive endoderm cells of inner cell mass in blastocysts. These cells have self-renewal properties and differentiate into visceral endoderm (VE) and parietal endoderm (PE) of the yolk sac. Recently, it has been reported that XEN cells can contribute to fetal embryonic endoderm, and their unique potency has been evaluated. In this study, we have described the induction and characterization of new canine stem cell lines that closely resemble to XEN cells...
April 25, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28467334/quality-control-on-radiochemical-purity-in-technetium-99m-radiopharmaceuticals-labelling-three-years-of-experience-on-2280-procedures
#19
Claudio Maioli, Giovanni Luciniani, Aldo Strinchini, Luca Tagliabue, Angelo Del Sole
OBJECTIVE: the purpose of this study was to offer an example of evaluations of the ISO9001 certified internal quality assurance (QA) system of 99mTc-radiopharmaceutical preparations and quality control in vivo use, using industrial kits and generators in order to identify possible sources of errors in the procedures labeling and quality control procedures. METHODS: The study was performed at a single institution over a period of three years (July 1st, 2011 - July 1st, 2014), and included a total of 2280 radiopharmaceutical preparations prepared by four different technologists...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28453249/complete-mapping-of-complex-disulfide-patterns-with-closely-spaced-cysteines-by-in-source-reduction-and-data-dependent-mass-spectrometry
#20
Christian N Cramer, Christian D Kelstrup, Jesper V Olsen, Kim F Haselmann, Peter Kresten Nielsen
Mapping of disulfide bonds is an essential part of protein characterization to ensure correct cysteine pairings. For this, mass spectrometry (MS) is the most widely used technique due to fast and accurate characterization. However, MS-based disulfide mapping is challenged when multiple disulfide bonds are present in complicated patterns. This includes the presence of disulfide bonds in nested patterns and closely spaced cysteines. Unambiguous mapping of such disulfide bonds typically requires advanced MS approaches...
June 6, 2017: Analytical Chemistry
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