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https://www.readbyqxmd.com/read/27913823/mathematical-models-suggest-facilitated-fatty-acids-crossing-of-the-luminal-membrane-in-the-cardiac-muscle
#1
Efrath Barta
Long-chain fatty acids cross a few membranes on their way from the capillary blood to the cardiomyocyte cytosol, where they are utilized as an essential source of energy. Details of the transport mechanism across those membranes remained elusive despite decades of laboratory and theoretical work. Here we inspect several optional scenarios for the crossing of the luminal membrane of the endothelial cell, the first barrier that should be crossed: a passive diffusion, facilitation by receptors for albumin and facilitation by fatty acids transporters...
December 3, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27903492/angiotensinogen-import-in-isolated-proximal-tubules-evidence-for-mitochondrial-trafficking-and-uptake
#2
Bryan A Wilson, Nildris Cruz-Diaz, Yixin Su, James C Rose, TanYa M Gwathmey, Mark C Chappell
The renal proximal tubules are a key functional component of the kidney and express the angiotensin precursor angiotensinogen; however, it is unclear the extent that tubular angiotensinogen reflects local synthesis or internalization. Therefore, the current study established the extent that angiotensinogen is internalized by proximal tubules and the intracellular distribution. Proximal tubules were isolated from the kidney cortex of male sheep by enzymatic digestion and a discontinuous Percoll gradient. Tubules were incubated with radiolabeled 125I-angiotensinogen for 2 hrs at 37°C in serum/phenol-free DMEM/F12 media...
November 30, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27895531/follicular-fluid-biomarkers-for-human-in-vitro-fertilization-outcome-proof-of-principle
#3
Fang Chen, Carl Spiessens, Thomas D'Hooghe, Karen Peeraer, Sebastien Carpentier
BACKGROUND: Human follicular fluid (FF) is a unique biological fluid in which the oocyte develops in vivo, and presents an optimal source for non-invasive biochemical predictors. Oocyte quality directly influences the embryo development and hence, may be used as a predictor of embryo quality. Peptide profiling of FF and its potential use as a biomarker for oocyte quality has never been reported. METHODS: This study screened FF for peptide biomarkers that predict the outcome of in vitro fertilization (IVF)...
2016: Proteome Science
https://www.readbyqxmd.com/read/27862254/hk2-proximal-tubule-epithelial-cells-synthesize-and-secrete-plasma-proteins-predominantly-through-the-apical-surface
#4
Ke-Wei Zhao, Elsa J Brochmann Murray, Samuel S Murray
Renal proximal tubule epithelial cells (PTECs) are known to reabsorb salts and small plasma proteins filtered through Bowman's capsule. Following acute kidney injury, PTECs assume some characteristics of hepatocytes in producing various plasma proteins. We now demonstrate that even at a resting state, a PTEC cell line, HK2 expresses mRNAs for and synthesizes and secretes plasma proteins in a complex with complement C3, an α2 -macroglobulin family chaperone, including albumin, transferrin, α1 -antitrypsin, α1 -antichymotrypsin, α2 -HS-glycoprotein, ceruloplasmin, haptoglobin, C1-inhibitor, secreted phosphoprotein-24, and insulin-like growth factor-1...
November 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27857516/sentinel-lymph-node-scintigraphy-in-cutaneous-melanoma-using-a-planar-calibration-phantom-filled-with-tc-99m-pertechnetate-solution-for-body-contouring
#5
Claudiu Peştean, Elena Bărbuş, Andra Piciu, Maria Iulia Larg, Alexandrina Sabo, Cristina Moisescu-Goia, Doina Piciu
BACKGROUND AND AIMS: Melanoma is a disease that has an increasing incidence worldwide. Sentinel lymph node scintigraphy is a diagnostic tool that offers important information regarding the localization of the sentinel lymph nodes offering important input data to establish a pertinent and personalized therapeutic strategy. The golden standard in body contouring for sentinel lymph node scintigraphy is to use a planar flood source of Cobalt-57 (Co-57) placed behind the patients, against the gamma camera...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27830352/antioxidant-and-antihypertensive-potential-of-protein-fractions-from-flour-and-milk-substitutes-from-canary-seeds-phalaris-canariensis-l
#6
María Elena Valverde, Domancar Orona-Tamayo, Blanca Nieto-Rendón, Octavio Paredes-López
Canary seed (Phalaris canariensis) is used to feed birds but it has been recently considered a promising cereal with nutraceutical potential for humans. The aim of this work was to analyze the protein fractions from canary seed flour and from milk substitutes (prepared by soaking the seeds in water 12 and 24 h), and to evaluate antioxidant and antihypertensive capacity of peptides obtained after in vitro digestion. Prolamins were the major protein fraction, followed by glutelins. After digestion, albumins and prolamins fractions from milks presented higher levels of peptides than flour, globulins showed more peptides in flour and glutelins were found in similar concentrations in all samples; 24 h milk prolamins had the highest concentration of peptides...
November 9, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27806669/cell-expansion-during-directed-differentiation-of-stem-cells-toward-the-hepatic-lineage
#7
Ravali Raju, David Chau, Dong Seong Cho, Yonsil Park, Catherine Verfaillie, Wei-Shou Hu
The differentiation of human pluripotent stem cells (hPSCs) towards the hepatocyte lineage can potentially provide an unlimited source of functional hepatocytes for transplantation and extracorporeal bioartificial liver applications. It is anticipated that the quantities of cells needed for these applications will be in the order of 10<sup>9</sup>-10<sup>10</sup>cells, because of the size of the liver. An ideal differentiation protocol would be to enable directed differentiation to the hepatocyte lineage with simultaneous cell expansion...
November 2, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27797973/integrative-systemic-and-local-metabolomics-with-impact-on-survival-in-high-grade-serous-ovarian-cancer
#8
Anna Bachmayr-Heyda, Stefanie Aust, Katharina Auer, Samuel M Meier, Klaus G Schmetterer, Sabine Dekan, Christopher Gerner, Dietmar Pils
PURPOSE: Cancer metabolism is characterized by alterations including aerobic glycolysis, oxidative phosphorylation, and need of fuels and building blocks. EXPERIMENTAL DESIGN: Targeted metabolomics of pre-operative and follow-up sera, ascites, and tumor tissues, RNA sequencing of isolated tumor cells, local and systemic chemokine and local immune cell infiltration data from up to 65 high grade serous ovarian cancer patients and 62 healthy controls were correlated to overall survival and integrated in a Systems Medicine manner...
October 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27767181/efficient-recellularisation-of-decellularised-whole-liver-grafts-using-biliary-tree-and-foetal-hepatocytes
#9
Satoshi Ogiso, Kentaro Yasuchika, Ken Fukumitsu, Takamichi Ishii, Hidenobu Kojima, Yuya Miyauchi, Ryoya Yamaoka, Junji Komori, Hokahiro Katayama, Takayuki Kawai, Elena Yukie Yoshitoshi, Sadahiko Kita, Katsutaro Yasuda, Shinji Uemoto
A whole-organ regeneration approach, using a decellularised xenogeneic liver as a scaffold for the construction of a transplantable liver was recently reported. Deriving suitable scaffolds was the first step towards clinical application; however, effective recellularisation remains to be achieved. This report presents a strategy for the improvement of the recellularisation process, using novel cell-seeding technique and cell source. We evaluated recellularised liver grafts repopulated through the portal vein or the biliary duct with mice adult hepatocytes or E14...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27764914/the-effects-of-high-fat-diets-composed-of-different-animal-and-vegetable-fat-sources-on-the-health-status-and-tissue-lipid-profiles-of-male-japanese-quail-coturnix-coturnix-japonica
#10
Janine Donaldson, Michael Taurai Madziva, Kennedy Honey Erlwanger
Objective: The current study aimed to investigate the impact of high-fat diets composed of different animal and vegetable fat sources on serum metabolic health markers in Japanese quail, as well as the overall lipid content and fatty acid profiles of the edible bird tissues following significantly increased dietary lipid supplementation. Methods: Fifty seven male quail were divided into six groups and fed either a standard diet or a diet enriched with one of five different fats (22 % coconut oil, lard, palm oil, soybean oil or sunflower oil) for 12 weeks...
October 20, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27749892/quantitation-and-identification-of-intact-major-milk-proteins-for-high-throughput-lc-esi-q-tof-ms-analyses
#11
Delphine Vincent, Aaron Elkins, Mark R Condina, Vilnis Ezernieks, Simone Rochfort
Cow's milk is an important source of proteins in human nutrition. On average, cow's milk contains 3.5% protein. The most abundant proteins in bovine milk are caseins and some of the whey proteins, namely beta-lactoglobulin, alpha-lactalbumin, and serum albumin. A number of allelic variants and post-translationally modified forms of these proteins have been identified. Their occurrence varies with breed, individuality, stage of lactation, and health and nutritional status of the animal. It is therefore essential to have reliable methods of detection and quantitation of these proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27743910/carbonylated-proteins-exposed-to-uva-and-to-blue-light-generate-reactive-oxygen-species-through-a-type-i-photosensitizing-reaction
#12
Taeko Mizutani, Hijiri Sumida, Yuki Sagawa, Yuri Okano, Hitoshi Masaki
BACKGROUND: Carbonylated proteins (CPs) are generated by the reaction of basic amino acid residues in proteins with aldehyde compounds produced during lipid peroxidation. CPs in the stratum corneum (SC) impact skin conditions such as skin moisture functions including water content and transepidermal water loss (TEWL). In addition, CPs can be frequently seen in the SC from sun-exposed sites compared with sun-protected sites. OBJECTIVE: The aim of this study was to reveal whether CPs could be a generation source of reactive oxygen species (ROS) in the SC following exposure to ultraviolet (UV) radiation and to identify the type of ROS and its generation mechanism...
September 28, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27738675/light-or-oxidation-triggered-co-release-from-mn-i-co-3-%C3%AE%C2%BA-3-l-complexes-reaction-intermediates-and-a-new-synthetic-route-to-mn-%C3%AE-o-2-l-2-compounds
#13
Ulf Sachs, Gerrit Schaper, Daniela Winkler, Daniel Kratzert, Philipp Kurz
The reaction products and intermediates of the three CO-releasing manganese(i) coordination compounds [Mn(tpm)(CO)3](+), [Mn(bpza)(CO)3] and [Mn(tpa)(CO)3](+) were analysed by combining IR-spectroscopy, electrochemical measurements and single-crystal XRD. The intermediate formation of manganese(i) biscarbonyl compounds and the rather facile oxidation of these species were identified as key reaction steps that accompany CO liberation. For the use of [Mn(I)(CO)3] complexes as light-triggered CO sources, the results indicate that in this case photo- and redox-chemistry seem to be strongly coupled which could be important and potentially even useful in the pharmacological context...
October 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27719953/protein-precipitating-capacity-and-antioxidant-activity-of-turkish-tombul-hazelnut-phenolic-extract-and-its-fractions
#14
Ebru Pelvan Pelitli, Michał Adam Janiak, Ryszard Amarowicz, Cesarettin Alasalvar
Natural (raw) hazelnut was extracted with 80% (v/v) acetone to obtain crude phenolic extract that was then fractionated for elution of low-molecular weight (LMW) and high-molecular weight (HMW) fractions. LMW fraction was further purified (LWM-FP) to remove sugars and organic acids. The crude extract and its fractions were determined by measuring their protein precipitating capacity (PPC) using two different proteins [bovine serum albumin (BSA) and gelatin], molecular weights, total phenolics, condensed tannins, and various antioxidant activities...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27689307/serum-protein-concentration-in-low-dose-total-body-irradiation-of-normal-and-malnourished-rats
#15
W C M Viana, D Lambertz, E S Borges, A M O Neto, K M F T Lambertz, A Amaral
Among the radiotherapeutics' modalities, total body irradiation (TBI) is used as treatment for certain hematological, oncological and immunological diseases. The aim of this study was to evaluate the long-term effects of low-dose TBI on plasma concentration of total protein and albumin using prematurely and undernourished rats as animal model. For this, four groups with 9 animals each were formed: Normal nourished (N); Malnourished (M); Irradiated Normal nourished (IN); Irradiated Malnourished (IM). At the age of 28 days, rats of the IN and IM groups underwent total body gamma irradiation with a source of cobalt-60...
September 20, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27630776/proteases-from-canavalia-ensiformis-active-and-thermostable-enzymes-with-potential-of-application-in-biotechnology
#16
Rayane Natshe Gonçalves, Suellen Duarte Gozzini Barbosa, Raquel Elisa da Silva-López
Extracts of leaves, seeds, roots, and stem from a tropical legume, C. ensiformis, were prepared employing buffers and detergent in aqueous solution. Leaf extracts had the highest protein content and the most pronounced peptidase activity with optimal pH in the neutral to alkaline range. All extracts exhibited peaks of activity at various pH values, suggesting the presence of distinctive classes of proteases. N-α-Tosyl-L-arginine methyl ester hydrolysis was maximal at 30°C to 60°C and peptidase activity from all extracts presented very good thermal stability after 24 h incubation at 70°C...
2016: Biotechnology Research International
https://www.readbyqxmd.com/read/27621524/general-unknown-screening-antioxidant-and-anti-inflammatory-potential-of-dendrobium-macrostachyum-lindl
#17
Nimisha Pulikkal Sukumaran, R Hiranmai Yadav
CONTEXT: D. macrostachyum is an epiphytic orchid abundant in Southern India and is reported for pain relief in folklore. AIMS: The objective of the present study was to determine in vitro free radical scavenging and anti-inflammatory activity of D. macrostachyum and to perform LCMS based metabolic profiling of the plant. SETTINGS AND DESIGN: Sequential stem and leaf extracts were assessed for its antioxidant and anti-inflammatory activity by in vitro methods...
April 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27619809/albumin-bilirubin-score-predicting-short-term-outcomes-including-bile-leak-and-post-hepatectomy-liver-failure-following-hepatic-resection
#18
Nikolaos Andreatos, Neda Amini, Faiz Gani, Georgios A Margonis, Kazunari Sasaki, Vanessa M Thompson, David J Bentrem, Bruce L Hall, Henry A Pitt, Ana Wilson, Timothy M Pawlik
INTRODUCTION: Post-operative bile leak (BL) and post hepatectomy liver failure (PHLF) are the major potential sources of morbidity among patients undergoing liver resection. We sought to define the incidence of BL and PHLF among a large cohort of patients, as well as examine the prognostic impact of model for end-stage liver disease (MELD) and albumin-bilirubin (ALBI) scores to predict these short-term outcomes. MATERIALS AND METHODS: Patients who underwent a hepatectomy between January 1, 2014 and December 31, 2014 were identified using the National Surgical Quality Improvement Program (NSQIP) liver-targeted database...
September 12, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27612992/the-comparison-of-animal-models-for-premature-ovarian-failure-established-by-several-different-source-of-inducers
#19
Ting Zhang, Dawei Yan, Yang Yang, Aicui Ma, Lei Li, Zhonghui Wang, Qi Pan, Zuyue Sun
The objective of this study was to compare premature ovarian failure animal models established by several different source of inducers. Female ICR mice, KM mice, and SD rats were treated by cyclophosphamide at 120 mg/kg, busulfan at 12 mg/kg, cisplatin at 3 or 4 mg/kg, 4-vinylcyclohexene diepoxide at 160 mg/kg, 35% galactose food pellet, and tripterygium glycosides at 50 mg/kg, respectively. Parameters were analyzed by body weight, serum concentration level of related hormones, ovarian and uterine pathological examination...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27610585/ischemia-modified-albumin-is-a-predictor-of-short-term-mortality-in-patients-with-severe-sepsis
#20
Mei Yin, Xuezhong Liu, Xiaomei Chen, Chen Li, Weidong Qin, Hui Han, Haipeng Guo, Hongna Yang, Dongming Cao, Zhanhui Du, Dawei Wu, Hao Wang
PURPOSE: One of the most important events leading to morbidity and mortality in patients with severe sepsis is the development of global tissue hypoperfusion and oxidative damage. Ischemia-modified albumin (IMA), an albumin generated under ischemic and oxidative conditions, is a marker of oxidative stress and hypoperfusion. Here, we investigated whether IMA level could predict short-term mortality with severe sepsis. METHODS: A prospective cohort study was conducted from April 2014 to October 2014 in intensive care units in a tertiary hospital...
August 11, 2016: Journal of Critical Care
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