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https://www.readbyqxmd.com/read/29779268/variation-in-polyphenolic-profiles-antioxidant-and-antimicrobial-activity-of-different-achillea-species-as-natural-sources-of-antiglycative-compounds
#1
Mahvash Afshari, Mehdi Rahimmalek, Mehran Miroliaei
A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC50 = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC...
May 19, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29779026/uromodulin-mrna-from-urinary-extracellular-vesicles-correlate-to-kidney-function-decline-in-type-2-diabetes-mellitus
#2
Cindy M Yamamoto, Taku Murakami, Melanie L Oakes, Masato Mitsuhashi, Colleen Kelly, Robert R Henry, Kumar Sharma
BACKGROUND: Extracellular vesicles (EVs) enclose mRNA derived from their cell of origin and are considered a source of potential biomarkers. We examined urinary EV mRNA from individuals with diabetic kidney disease (DKD), chronic kidney disease, type 2 diabetes (T2DM), and obese and healthy controls to determine if such biomarkers had the potential to classify kidney disease and predict patients at higher risk of renal function decline. METHODS: A total of 242 participants enrolled in this study...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29755300/the-effect-of-gel-microstructure-on-simulated-gastric-digestion-of-protein-gels
#3
Mauricio Opazo-Navarrete, Marte D Altenburg, Remko M Boom, Anja E M Janssen
The objective of this study was to analyse the impact of the gel structure obtained by different heat-induced temperatures on the in vitro gastric digestibility at pH 2. To achieve this, gels were prepared from soy protein, pea protein, albumin from chicken egg white and whey protein isolate at varying temperatures (90, 120 and 140 °C) for 30 min. Gels were characterised prior to digestion via microstructure and SDS-PAGE analysis. Subsequently, the gastric digestion process was followed via the protein hydrolysis and HPSEC analysis up to 180 min...
2018: Food Biophysics
https://www.readbyqxmd.com/read/29718255/mitochondrial-dna-is-a-pro-inflammatory-damage-associated-molecular-pattern-released-during-active-ibd
#4
Ray K Boyapati, David A Dorward, Arina Tamborska, Rahul Kalla, Nicholas T Ventham, Mary K Doherty, Philip D Whitfield, Mohini Gray, Joseph Loane, Adriano G Rossi, Jack Satsangi, Gwo-Tzer Ho
Background: Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA. MtDNA is recognized as a pro-inflammatory damage-associated molecular pattern (DAMP) with a pathogenic role in several inflammatory diseases. We hypothesised that mtDNA is released during active disease, serving as a key pro-inflammatory factor in inflammatory bowel disease (IBD). Methods: Between 2014 and 2015, we collected plasma separated within 2 hours of sampling from 97 prospectively recruited IBD patients (67 ulcerative colitis [UC] and 30 Crohn's disease [CD]) and 40 non-IBD controls...
May 1, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29713565/increased-chemical-acetylation-of-peptides-and-proteins-in-rats-after-daily-ingestion-of-diacetyl-analyzed-by-nano-lc-ms-ms
#5
Leticia Dias Lima Jedlicka, Sheila Barreto Guterres, Aleksandro Martins Balbino, Giuseppe Bruno Neto, Richardt Gama Landgraf, Liliam Fernandes, Emanuel Carrilho, Etelvino José Henriques Bechara, Nilson A Assuncao
Background: Acetylation alters several protein properties including molecular weight, stability, enzymatic activity, protein-protein interactions, and other biological functions. Our previous findings demonstrating that diacetyl/peroxynitrite can acetylate L-lysine, L-histidine, and albumin in vitro led us to investigate whether diacetyl-treated rats suffer protein acetylation as well. Methods: Wistar rats were administered diacetyl daily for four weeks, after which they were sacrificed, and their lung proteins were extracted to be analysed by Nano-LC-MS/MS (Q-TOF)...
2018: PeerJ
https://www.readbyqxmd.com/read/29695308/the-presence-of-human-mesenchymal-stem-cells-of-renal-origin-in-amniotic-fluid-increases-with-gestational-time
#6
Md Shaifur Rahman, Lucas-Sebastian Spitzhorn, Wasco Wruck, Carsten Hagenbeck, Percy Balan, Nina Graffmann, Martina Bohndorf, Audrey Ncube, Pascale V Guillot, Tanja Fehm, James Adjaye
BACKGROUND: Established therapies for managing kidney dysfunction such as kidney dialysis and transplantation are limited due to the shortage of compatible donated organs and high costs. Stem cell-based therapies are currently under investigation as an alternative treatment option. As amniotic fluid is composed of fetal urine harboring mesenchymal stem cells (AF-MSCs), we hypothesized that third-trimester amniotic fluid could be a novel source of renal progenitor and differentiated cells...
April 25, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29693144/preliminary-analysis-of-the-protein-profile-in-saliva-during-physiological-term-and-preterm-delivery
#7
Maciej Łopucki, Jacek Wawrzykowski, Tomasz Gęca, Andrzej Miturski, Monika Franczyk, Marta Kankofer
From a clinical point of view, easily obtainable and useful markers of a particular pathological status are required for appropriate diagnosis and treatment. Analysis of the proteomic profile of saliva may allow for the selection of potential marker of preterm delivery in humans. Saliva samples were collected from 12 patients diagnosed with threatened preterm delivery and 10 controls with uncomplicated pregnancies at the same gestational age. Samples were analysed using 2D electrophoresis. Based on statistical analysis, spots of interest were selected and collected from gels...
April 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29672963/butein-protects-the-nonalcoholic-fatty-liver-through-mitochondrial-reactive-oxygen-species-attenuation-in-rats
#8
Ghedeir M Alshammari, Aristatile Balakrishnan, Thirunavukkarasu Chinnasamy
One of the worldwide metabolic health dilemma is nonalcoholic fatty liver diseases (NAFLD). Researchers are searching effective drug to manage NAFLD patients. One of the best way to manage the metabolic imperfection is through natural principal isolated from different sources. Butein, a natural compound known to have numerous pharmacological application. In the current study we assessed the therapeutic effect of butein administration on liver function tests, oxidative stress, antioxidants, lipid abnormalities, serum inflammatory cytokines, and mitochondrial reactive oxygen species levels, in rats with methionine-choline deficient (MCD) diet induced NAFLD...
April 19, 2018: BioFactors
https://www.readbyqxmd.com/read/29663181/effects-of-dietary-organic-inorganic-and-nanoparticulate-selenium-sources-on-growth-hemato-immunological-and-serum-biochemical-parameters-of-common-carp-cyprinus-carpio
#9
Sadegh Saffari, Saeed Keyvanshokooh, Mohammad Zakeri, Seyed Ali Johari, Hossein Pasha-Zanoosi, Mansour Torfi Mozanzadeh
An 8-week feeding trial was conducted to compare the effects of supplementing (0.7 mg kg-1 ) different dietary selenium (Se) sources including organic [selenomethionine (SeMet)], inorganic [sodium selenite (Na2 SeO3 )], and nanoparticulate Se (nano-Se) on physiological responses of common carp, Cyprinus carpio juveniles (9.7 ± 0.1 g). Basal diet without Se supplementation used as control. Fish fed nano-Se supplemented diet had the highest weight gain (97.2 ± 10.8%) and feed efficiency ratio (42...
April 16, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29625371/purification-of-human-erythropoietin-by-affinity-chromatography-using-cyclic-peptide-ligands
#10
William S Kish, Matthew K Roach, Hiroyuki Sachi, Amith D Naik, Stefano Menegatti, Ruben G Carbonell
Prior work described the identification and characterization of erythropoietin-binding cyclic peptides SLFFLH, VVFFVH, FSLLHH and FSLLSH (all of the form cyclo[(Nα -Ac)Dap(A)-X1 -X6 -AE], wherein X1 -X6 is the listed sequences). In this work, the peptide ligands were synthesized on Toyopearl chromatographic resins and utilized for purifying recombinant human erythropoietin (rHuEPO) from complex sources. Elution buffer pH and composition were optimized to maximize the recovery of standard rHuEPO from the peptide resins...
March 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29624009/the-concentration-of-free-amino-acids-in-blood-serum-of-dairy-cows-with-primary-ketosis
#11
J Marczuk, P Brodzki, A Brodzki, Ł Kurek
Ketosis is a common condition found in the initial stages of lactation in high-yielding dairy cows. The major cause of ketosis is a negative energy balance. During the energy deficiency, proteolysis processes develop parallel to lipolysis. During proteolysis, muscle tissue can be used as a source of amino acid. To date, the participation of amino acids in gluconeogenesis (glucogenic amino acids) and ketogenesis (ketogenic amino acids) has not been determined in detail. This paper presents the study on determination of the parameters of protein and free amino acid metabolism in blood serum of dairy cows with primary ketosis compared to healthy cows...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29613958/the-impact-of-age-on-the-innate-immune-response-and-outcomes-after-severe-sepsis-septic-shock-in-trauma-and-surgical-intensive-care-unit-patients
#12
Scott C Brakenridge, Philip A Efron, Julie A Stortz, Teczan Ozrazgat-Baslanti, Gabriela Ghita, Zhongkai Wang, Azra Bihorac, Alicia M Mohr, Babette A Brumback, Lyle L Moldawer, Frederick A Moore
INTRODUCTION: Advancing age is a strong risk factor for adverse outcomes across multiple disease processes. However, septic surgical and trauma patients are unique in they incur two or more inflammatory insults. The effects of advanced age on sepsis pathophysiology and outcomes remain unclear. METHODS: We performed a single center, prospective observational cohort study of Surgical ICU patients with severe sepsis/septic shock. Peripheral blood was collected for genomic, cytokine and biomarker analysis at 0...
April 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29564928/cryptides-latent-peptides-everywhere
#13
Federica Iavarone, Claudia Desiderio, Alberto Vitali, Irene Messana, Claudia Martelli, Massimo Castagnola, Tiziana Cabras
Proteomic surveys with top-down platforms are today revealing thousands of naturally occurring fragments of bigger proteins. Some of them have not functional meaning because they derive from pathways responsible for protein degradation, but many have specific functions, often completely different from that one of the parent proteins. These peptides encrypted in the protein sequence are nowadays called cryptides. They are frequent in the animal and plant kingdoms and represent a new interesting -omic field of investigation...
March 22, 2018: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29562935/a-pooled-analysis-of-mesenchymal-stem-cell-based-therapy-for-liver-disease
#14
REVIEW
Lu Zhao, Shanquan Chen, Xiaowei Shi, Hongcui Cao, Lanjuan Li
BACKGROUND: Liver disease is a major cause of death and disability. Mesenchymal stem cells (MSCs) show promise for the treatment of liver disease. However, whether MSC-based therapy is more effective than conventional treatment is unclear, as are the optimal MSC source, the administration frequency, and the most effective MSC delivery route. We therefore undertook a systematic review and meta-analysis of the therapeutic efficacy of MSCs against liver disease and the related factors. METHODS: We systematically searched Medline (PubMed), Cochrane Library, EMBASE, ClinicalTrials...
March 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29562678/atypical-kinetics-and-albumin-effect-of-glucuronidation-of-5-n-butyl-4-4-2-1h-tetrazole-5-yl-1h-pyrrol-1-yl-phenylmethyl-2-4-dihydro-2-2-6-dichlorophenyl-3h-1-2-4-triazol-3-one-a-novel-nonpeptide-angiotensin-type-1-receptor-antagonist-in-liver-microsomes-and
#15
Ying Peng, Xueyuan Zhang, Yinci Zhu, Hui Wu, Shiyin Gu, Qingqing Chang, Yi Zhou, Guangji Wang, Jianguo Sun
Ib is a new nonpeptide AT1 receptor antagonist, which plays an active role in cardiovascular protection. Ib monoglucuronide has been identified as its main metabolite. A detailed study of Ib glucuronidation is important for predicting potential DDI. Besides, the elucidation of the "BSA effect" in Ib glucuronidation would make obtained kinetic parameters more predictive in IVIVE. "BSA effect" means that there is a significant change in in vitro kinetic parameters when generated from incubations performed in the presence of bovine serum albumin (BSA)...
March 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29558429/antioxidant-activity-of-coconut-cocos-nucifera-l-protein-fractions
#16
Yan Li, Yajun Zheng, Yufeng Zhang, Jianguo Xu, Gang Gao
Coconut cake is an abundant and good potential edible protein source. However, until now it has not been extensively used in the food industry. To promote its usage, the characterization, nutrition value and antioxidant activity of coconut cake protein fractions (albumin, globulin, prolamine, glutelin-1 and glutelin-2) were studied. Results revealed that all the albumin, globulin, glutelin-1 and glutelin-2 fractions showed a high nutrition value. The prolamine, glutelin-1 and glutelin-2 all exhibited good radical scavenging activity and reducing power, and the globulin and prolamine showed high ion chelating ability (89...
March 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29552184/%C3%AE-%C3%AE-t-cell-mediated-individualized-immunotherapy-for-hepatocellular-carcinoma-considering-clinicopathological-characteristics-and-immunosuppressive-factors
#17
Wei Tian, Jun Ma, Ruyi Shi, Chongren Ren, Jiefeng He, Haoliang Zhao
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. γδ T cells have been revealed to be promising candidates for immunotherapy in patients with HCC. However, the use of these cells in clinical practice has been demonstrated to be challenging. In the present study, γδ T cells isolated from the peripheral blood of patients with HCC (n=83) and healthy donors (n=15) were characterized. Flow cytometry was used to analyze the proportion, phenotype, tumor-killing capacity and cytokine secretion of regulatory T cells (Tregs) and γδ T17 cells in peripheral blood samples prior to and following amplification...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29547375/promising-perspectives-for-ruminal-protection-of-polyunsaturated-fatty-acids-through-polyphenol-oxidase-mediated-crosslinking-of-interfacial-protein-in-emulsions
#18
N De Neve, B Vlaeminck, F Gadeyne, E Claeys, P Van der Meeren, V Fievez
Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (>80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato tuber peelings. However, until now, emulsions of only 2 wt% oil have been successfully protected, which implies serious limitations both from a research perspective (e.g. in vivo trials) as well as for further upscaling toward practical applications. Therefore, the aim of this study was to increase the oil/PPO ratio...
March 16, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29545737/mung-bean-proteins-and-peptides-nutritional-functional-and-bioactive-properties
#19
Zhu Yi-Shen, Sun Shuai, Richard FitzGerald
To date, no extensive literature review exists regarding potential uses of mung bean proteins and peptides. As mung bean has long been widely used as a food source, early studies evaluated mung bean nutritional value against the Food and Agriculture Organization of the United Nations (FAO)/the World Health Organization (WHO) amino acids dietary recommendations. The comparison demonstrated mung bean to be a good protein source, except for deficiencies in sulphur-containing amino acids, methionine and cysteine...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29533151/comparison-of-renal-function-and-other-predictors-in-lacto-ovo-vegetarians-and-omnivores-with-chronic-kidney-disease
#20
Chou-Yueh Chang, Horng-Rong Chang, Hsing-Chun Lin, Han-Hsin Chang
Objective Vegetarian diets have been shown to increase the risk of certain nutritional deficiencies, such as iron. As a number of patients with chronic kidney disease (CKD) in Taiwan are lacto-ovo vegetarians, the aim of this study was to investigate the effects of different proportions and sources of protein in lacto-ovo vegetarian and omnivorous diets, as well as the influence of adequate dietary protein intake, on renal function and nutritional status of Taiwanese patients with stage 3 to stage 5 CKD. Methods This is a cross-sectional study...
March 13, 2018: Journal of the American College of Nutrition
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