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https://www.readbyqxmd.com/read/29779220/human-intrabony-defect-regeneration-with-micro-grafts-containing-dental-pulp-stem-cells-a-randomized-controlled-clinical-trial
#1
Francesco Ferrarotti, Federica Romano, Mara Noemi Gamba, Andrea Quirico, Marta Giraudi, Martina Audagna, Mario Aimetti
AIM: The goal of this study was to evaluate if dental pulp stem cells (DPSCs) delivered into intrabony defects in a collagen scaffold would enhance the clinical and radiographic parameters of periodontal regeneration. MATERIALS AND METHODS: In this randomized controlled trial, 29 chronic periodontitis patients presenting one deep intrabony defect and requiring extraction of one vital tooth were consecutively enrolled. Defects were randomly assigned to test or control treatments which both consisted of the use of minimally invasive surgical technique...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29776890/burch-schneider-ring-associated-with-morselized-bone-allografts-survival-and-clinical-outcomes-after-acetabular-revision-surgery
#2
A Torres-Campos, J Albareda Albareda, B Seral García, N Blanco Rubio, J Gómez Vallejo, L Ezquerra Herrando
INTRODUCTION AND OBJECTIVES: Acetabular revision surgery is a challenge due to the appearance of bone defects that make primary fixation of implants difficult when extracting loosened components. Reinforcement rings, such as Burch-Schneider (BS), have been shown to be allies in moderate or severe bone defects. The objective of the study is to evaluate the results and survival of these types of implants in acetabular revision surgery in the medium follow-up. MATERIAL AND METHODS: Retrospective study on a cohort of 64 patients (67 replacements) with BS rings associated with morselized bone allografts in a 2 years minimum follow-up...
May 15, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29776425/combined-application-of-latissimus-dorsi-myocutaneous-flap-and-iliac-bone-flap-in-the-treatment-of-chronic-osteomyelitis-of-the-lower-extremity
#3
Jihui Ju, Lei Li, Rong Zhou, Ruixing Hou
BACKGROUND: To evaluate the clinical efficacy and safety of latissimus dorsi myocutaneous flap (stage I) combined with iliac bone flap (stage II) in the treatment of chronic osteomyelitis of the lower extremity. METHODS: Clinical data of 18 patients undergoing latissimus dorsi myocutaneous flap in combination with iliac bone flap grafting were retrospectively analyzed. Among them, 2 patients developed chronic osteomyelitis of the lower segment of the femur, 4 were diagnosed with chronic osteomyelitis of the tibial plateau, and 12 with chronic osteomyelitis of the lower segment of the tibia...
May 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29775983/classification-and-microvascular-flap-selection-for-anterior-cranial-fossa-reconstruction
#4
James D Vargo, Wojciech Przylecki, Paul J Camarata, Brian T Andrews
BACKGROUND:  Microvascular reconstruction of the anterior cranial fossa (ACF) creates difficult challenges. Reconstructive goals and flap selection vary based on the defect location within the ACF. This study evaluates the feasibility and reliability of free tissue transfer for salvage reconstruction of low, middle, and high ACF defects. METHODS:  A retrospective review was performed. Reconstructions were anatomically classified as low (anterior skull base), middle (frontal bar/sinus), and high (frontal bone/soft tissue)...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29774969/combined-effect-of-parathyroid-hormone-and-strontium-ranelate-on-bone-healing-in-ovariectomized-rats
#5
Funda Göker, Selim Ersanlı, Volkan Arısan, Erdal Cevher, Emine Elif Güzel, Halim İşsever, Beyhan Ömer, Gülay Durmuş Altun, Deniz Morina, Tuğba Ekiz Yılmaz, Elmire Dervişoğlu, Massimo Del Fabbro
OBJECTIVE: Parathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical sized defects of ovariectomized rats. MATERIALS AND METHODS: PTH- and/or SR-containing poloxamer implant tablets with/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats...
May 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29773404/large-tibial-geode-which-developed-several-years-after-a-left-medial-oxford-unicondylar-knee-arthroplasty-treated-with-curettage-and-bone-grafting
#6
Matthew K Curran, James R Murray
BACKGROUND: Tibial geodes are rare, and usually reported in association with rheumatoid arthritis. This case study reported the rare occurrence of a tibial geode in association with a left unicondylar knee arthroplasty (UKA). The patient, a 55-year-old male, was initially pleased with his UKA, which was performed at another institution. However, just over one year after the operation he began experiencing pain and discomfort. He did not present to the current institution until he was six years after UKA...
May 14, 2018: Knee
https://www.readbyqxmd.com/read/29773281/-cutaneous-and-systemic-t-cell-lymphoma-treated-with-haploidentical-bone-marrow-transplantation
#7
M Méchineaud, M Mercier, Y Le Corre, A Croué, N Ifrah, L Martin
BACKGROUND: Herein, we report a case of systemic cutaneous T-cell lymphoma refractory to standard therapy, the course of which resulted in haplo-identical bone marrow grafting. PATIENTS AND METHODS: A 53-year-old woman consulted for facial erythema with infiltration, keratotic lesions on the trunk, and adenopathies measuring around 1cm on the axilla and inguinal folds. A diagnosis was made of Sézary syndrome (SS), a leukaemic form of epidermotropic cutaneous T-cell lymphoma...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29772271/pain-management-after-bone-reconstruction-surgery-using-an-analgesic-bone-cement-a-functional-non-invasive-in-vivo-study-using-gait-analysis
#8
Manon Dupleichs, Martial Masson, Olivier Gauthier, Maeva Dutilleul, Jean-Michel Bouler, Elise Verron, Pascal Janvier
Postoperative pain following bone reconstruction is a serious complication that could jeopardize the global success of a surgery. This pain must be controlled and minimized during the first 3-4 postoperative days to prevent it from becoming chronic. In this study, a critical-size bone defect was created at the femoral distal end of rats and filled by an injectable calcium phosphate cement (CPC) loaded or not with local anesthetics (bupivacaine or ropivacaine). A functional evaluation of the gait was performed using the CatWalk system to compare the postoperative pain relief enhanced by the different CPCs after such a bone filling surgery...
May 14, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29771732/maxillary-sinus-floor-augmentation-with-synthetic-bone-substitutes-compared-with-other-grafting-materials-a-systematic-review-and-meta-analysis
#9
Thomas Starch-Jensen, Arne Mordenfeld, Jonas Peter Becktor, Simon Storgård Jensen
OBJECTIVE: To test the hypotheses of no differences in implant treatment outcome after maxillary sinus floor augmentation (MSFA) with synthetic bone substitutes (SBS) compared with other grafting materials applying the lateral window technique. MATERIALS AND METHODS: A MEDLINE/PubMed, Embase and Cochrane Library search in combination with hand-search of selected journals was conducted. RESULTS: Five randomized controlled trials with low risk of bias fulfilled the inclusion criteria...
May 15, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29770879/no-difference-in-the-graft-shift-between-a-round-and-a-rounded-rectangular-femoral-tunnel-for-anterior-cruciate-ligament-reconstruction-an-experimental-study
#10
Yasushi Takata, Junsuke Nakase, Takeshi Oshima, Kengo Shimozaki, Kazuki Asai, Hiroyuki Tsuchiya
INTRODUCTION: We developed a novel technique of creating a rounded rectangular femoral bone tunnel for anatomical, single-bundle, autologous hamstring tendon anterior cruciate ligament (ACL) reconstruction. Although this tunnel has many advantages, its non-circular shape has raised concerns regarding excessive graft shift within the bone tunnel. This study aimed to compare the graft shift between round and rounded rectangular tunnels using a graft diameter tester for simulating the femoral bone tunnel...
May 16, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29770578/effect-of-silicon-doped-calcium-phosphate-bone-grafting-materials-on-bone-regeneration-and-osteogenic-marker-expression-after-implantation-in-the-ovine-scapula
#11
Christine Knabe, Doaa Adel-Khattab, Wolf-Dietrich Hübner, Fabian Peters, Tom Knauf, Barbara Peleska, Dirk Barnewitz, Antje Genzel, Roderik Kusserow, Florian Sterzik, Michael Stiller, Christian Müller-Mai
Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29769782/graft-versus-host-disease-presenting-as-fibrosing-alopecia-in-a-pattern-distribution-a-model-for-pathophysiological-understanding-of-cicatricial-pattern-hair-loss
#12
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA)...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29769146/finite-element-analysis-of-the-tibial-bone-graft-in-cementless-total-knee-arthroplasty
#13
Koji Totoribe, Etsuo Chosa, Go Yamako, Hiroaki Hamada, Koki Ouchi, Shutaro Yamashita, Gang Deng
BACKGROUND: Achieving stability of the tibial implant is essential following cementless total knee arthroplasty with bone grafting. We investigated the effects of bone grafting on the relative micromotion of the tibial implant and stress between the tibial implant and adjacent bone in the immediate postoperative period. METHODS: Tibial implant models were developed using a nonlinear, three-dimensional, finite element method. On the basis of a preprepared template, several bone graft models of varying sizes and material properties were prepared...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29769090/comparing-morbidities-of-bone-graft-harvesting-from-the-anterior-iliac-crest-and-proximal-tibia-a-retrospective-study
#14
Ying-Cheng Huang, Chun-Yu Chen, Kai-Cheng Lin, Jenn-Huei Renn, Yih-Wen Tarng, Chien-Jen Hsu, Wei-Ning Chang, Shan-Wei Yang
BACKGROUND: The anterior iliac crest (AIC) and proximal tibia (PT) are common donor sites for autologous bone graft harvesting. We compared pain levels at these harvest sites on 1 day, 5 days, 2 weeks, 4 weeks, and 8 weeks post-harvest. METHODS: We retrospectively reviewed 18 patients undergoing autologous bone grafting surgery at a level I trauma center between June 2013 and October 2014. Ten grafts were harvested from the AIC group and eight from the PT group...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29767434/regenerative-surgical-therapy-for-peri-implantitis-using-deproteinized-bovine-bone-mineral-with-10-collagen-enamel-matrix-derivative-and-doxycycline-a-prospective-3-year-cohort-study
#15
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
OBJECTIVES: There is limited evidence regarding the long-term efficacy of regenerative treatment for peri-implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and Doxycycline in the regeneration of bone defects associated with peri-implantitis. METHODS: Thirty patients diagnosed with peri-implantitis (BoP/suppuration, probing depth greater than 4 mm, minimum radiographic bone loss of 20%, at least 2 years in function) were enrolled in the study...
May 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#16
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29766671/point-of-care-treatment-of-focal-cartilage-defects-with-selected-chondrogenic-mesenchymal-stromal-cells-an-in-vitro-proof-of-concept-study
#17
Oliver Petters, Christian Schmidt, Christian Thuemmler, Frank Peinemann, Matthias Zscharnack, Jeremy S Somerson, Ronny M Schulz
Due to the poor self-healing capacities of cartilage, innovative approaches are a major clinical need. The use of in vitro expanded MSCs in a two-stage approach is accompanied by cost, time and personnel-intensive GMP production. A one-stage intra-operative procedure could overcome these drawbacks. The aim was to prove the feasibility of a point-of-care concept for the treatment of cartilage lesions using defined MSC subpopulations in a collagen hydrogel without prior MSC monolayer expansion. We tested four single marker candidates (MSCA-1, W4A5, CD146, CD271) for their effectiveness of separating colony-forming units of ovine MSCs via magnetic cell separation...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29766558/a-cure-rate-model-for-q-learning-estimating-an-adaptive-immunosuppressant-treatment-strategy-for-allogeneic-hematopoietic-cell-transplant-patients
#18
Erica E M Moodie, David A Stephens, Shomoita Alam, Mei-Jie Zhang, Brent Logan, Mukta Arora, Stephen Spellman, Elizabeth F Krakow
Cancers treated by transplantation are often curative, but immunosuppressive drugs are required to prevent and (if needed) to treat graft-versus-host disease. Estimation of an optimal adaptive treatment strategy when treatment at either one of two stages of treatment may lead to a cure has not yet been considered. Using a sample of 9563 patients treated for blood and bone cancers by allogeneic hematopoietic cell transplantation drawn from the Center for Blood and Marrow Transplant Research database, we provide a case study of a novel approach to Q-learning for survival data in the presence of a potentially curative treatment, and demonstrate the results differ substantially from an implementation of Q-learning that fails to account for the cure-rate...
May 16, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29766258/treatment-of-osteochondral-defects-with-a-combination-of-bone-grafting-and-amic-technique
#19
Arnd Hoburg, Julia Marcella Leitsch, Gerd Diederichs, Rex Lehnigk, Carsten Perka, Roland Becker, Sven Scheffler
INTRODUCTION: Osteochondral defects of the knee may cause functional impairment of young and sportively active patients. Different surgical treatment options have been proposed using either one or two step procedures. The aim of the current study was to evaluate mid-term outcomes of combined bone grafting with autologous matrix-associated chondrogenesis (AMIC) for the treatment of large osteochondral defects. MATERIALS AND METHODS: 15 Patients with osteochondrosis dissecans of the medial femoral condyle grade III or IV according to ICRS classification were treated with a single step surgical procedure combining bone grafting and the AMIC procedure...
May 15, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29765486/use-of-hyaluronic-acid-based-biological-bilaminar-matrix-in-wound-bed-preparation-a-case-series
#20
Richard Simman, Walid Mari, Sara Younes, Michael Wilson
Objective: Hyalomatrix, a matrix that consists of esterified hyaluronic acid, covered with a removable, semipermeable silicone top layer, was used to generate granulation tissue in a series of 12 serious, surgical wounds of different etiologies. Methods: Many defects showed exposed muscle, tendons, and/or bone. After thorough debridement, the matrix was applied, in a number of cases, combined with negative pressure wound therapy. Results: All wounds developed granulation tissue in and on top of the matrix. Nine wounds were then closed with a split skin autograft...
2018: Eplasty
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