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https://www.readbyqxmd.com/read/29050778/the-expressions-and-roles-of-different-forms-of-il-22-in-mycobacterium-tuberculosis-infection
#1
Yuanyuan Liu, Qinfang Ou, Qianqian Liu, Yan Gao, Jing Wu, Bingyan Zhang, Xinhua Weng, Lingyun Shao, Wenhong Zhang
Despite evidence suggesting an anti-Mycobacterium tuberculosis effector function of CD4+ T cells that produce and retain IL-22 in macaques, the general role of IL-22 in tuberculosis infection is still poorly characterized. To explore the immune mechanism in the pathogenesis of tuberculosis in humans, here we evaluated different forms of IL-22 in populations with different tuberculosis infection statuses. We enrolled 156 subjects including 49 patients with pulmonary tuberculosis, 27 patients with tuberculous pleurisy (TPE), 38 individuals with latent tuberculous infection (LTBI) and 42 healthy controls (HC)...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29047238/identification-of-10-candidate-biomarkers-distinguishing-tuberculous-and-malignant-pleural-fluid-by-proteomic-methods
#2
Chang Youl Lee, Ji Young Hong, Myung Goo Lee, In Bum Suh
PURPOSE: Pleural effusion, an accumulation of fluid in the pleural space, usually occurs in patients when the rate of fluid formation exceeds the rate of fluid removal. The differential diagnosis of tuberculous pleurisy and malignant pleural effusion is a difficult task in high tuberculous prevalence areas. The aim of the present study was to identify novel biomarkers for the diagnosis of pleural fluid using proteomics technology. MATERIALS AND METHODS: We used samples from five patients with transudative pleural effusions for internal standard, five patients with tuberculous pleurisy, and the same numbers of patients having malignant effusions were enrolled in the study...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29033441/bilateral-tuberculous-pleurisy-with-subsequent-upper-lobe-predominant-pulmonary-fibrosis-mimicking-pleuroparenchymal-fibroelastosis
#3
Takako Kawaguchi, Keishi Oda, Takashi Kido, Toshinori Kawanami, Yoshinori Kawabata, Kazuhiro Yatera
Although the majority of patients with Mycobacterium tuberculosis have pulmonary involvement, some cases have pleural involvement as extra-pulmonary sites of infection. We herein report a case of upper lobe-predominant pulmonary fibrosis that developed in a 47-year-old male with a history of bilateral tuberculous pleurisy. Based on his chest radiological findings, pleuroparenchymal fibroelastosis (PPFE) was most strongly suspected, and a surgical lung biopsy (SLB) was performed to obtain a pathological diagnosis...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29033435/clinical-features-of-nontuberculous-mycobacterial-pleurisy-a-review-of-12-cases
#4
Maiko Naito, Toshiya Maekura, Yu Kurahara, Masahiro Tahara, Naoya Ikegami, Yohei Kimura, Shoko Sonobe, Takehiko Kobayashi, Shojiro Minomo, Taisuke Tsuji, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
Objective The incidence of pulmonary nontuberculous mycobacterial (NTM) infections has increased in recent decades. Nevertheless, NTM pleurisy is still a rare disease. The objective of the present study was to elucidate the clinical features and outcomes of NTM pleurisy. Methods A retrospective study was undertaken of consecutive patients whose pleural effusion culture yielded NTM, from 2002 to 2016 at a respiratory hospital in Japan. The clinical features, treatment, and outcomes of these patients were analyzed...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28992933/early-life-indicators-predict-mortality-illness-reduced-welfare-and-carcass-characteristics-in-finisher-pigs
#5
Julia Adriana Calderón Díaz, Laura Ann Boyle, Alessia Diana, Finola Catherine Leonard, John Patrick Moriarty, Máire Catríona McElroy, Shane McGettrick, Denis Kelliher, Edgar García Manzanilla
The objective of this study was to investigate associations between early life indicators, lactation management factors and subsequent mortality, health, welfare and carcass traits of offspring. A total of 1016 pigs from a batch born during one week were used. During lactation, number of liveborn piglets, stillborn and mummies, sow parity, number of times cross-fostered, weaning age, birth and weaning body weight (BW) were collected. Mortality was recorded throughout the offspring production cycle. Prior to slaughter, pigs were scored for lameness (1=non-lame to 3=severely lame)...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28957888/usefulness-of-medical-thoracoscopy-in-the-management-of-pleural-effusion-caused-by-chronic-renal-failure
#6
Sara Colella, Federica Fioretti, Chiara Massaccesi, Gian L Primomo, Gianluca Panella, Vittorio D'Emilio, Riccardo Pela
INTRODUCTION: Although pleural effusion (PE) can be caused by several pathologies like congestive heart failure, infections, malignancies, and pulmonary embolism, it is also a common finding in chronic kidney disease (CKD). Diagnostic thoracentesis is of limited value in the differential diagnosis, and the role of more invasive investigations like medical thoracoscopy (MT) is still unclear. AIM: To evaluate the usefulness of MT in unexplained PE in CKD. MATERIALS AND METHODS: In the electronic database of our Institution, we retrospectively searched for patients with CKD who underwent MT for unexplained PE between January 2008 and August 2016...
October 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28942825/a-single-administration-of-fish-oil-inhibits-the-acute-inflammatory-response-in-rats
#7
Laura Lícia Milani de Arruda, Franciele Queiroz Ames, Damila Rodrigues de Morais, Renata Grespan, Ana Paula Maziero Gil, Maria Angélica Raffaini Covas Pereira Silva, Jesuí Vergílio Visentainer, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado
OBJECTIVE: To investigate the antiinflammatory effects of a single administration of fish oil (FO) on the acute inflammatory response. METHODS: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil (FOP) orally administered in a single dose in rats. Nitric oxide (NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28938508/-angina-pectoris-in-a-young-woman-with-lupus-erythematosus
#8
Simon Braumann, Malte P Bartram, Roman Pfister, Guido Michels
History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Treatment with NSAIDs was initiated and her immunosuppressive regimen intensified. The patient was discharged after resolution of her symptoms. A week later, the patient was seen at the rheumatology clinic with recurrence and aggravation of her symptoms...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28926021/the-economics-of-animal-welfare
#9
T J Gibson, E L Jackson
This paper examines four examples of animal welfare issues, demonstrating the interactions between welfare and economic principles. Welfare issues associated with purebred companion animals are examined in terms of predicted inherited diseases, highlighting the power of supply and demand in perpetuating traits in pets that compromise their well-being. The livestock industry is presented from the point of view of pig production and the impact that a major disease (pleurisy) has on production and the animals' welfare...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28904677/-pulmonary-nocardiosis-in-immunocompetent-patients-about-2-cases
#10
Yasmina Rhofir, Rachida Zahraoui, Nabil Tiress, Hicham Naji-Amrani, Mouna Soualhi, Jamal Eddine Bourkadi
Nocardiosis is a rare but severe infection caused by bacteria of the genus nocardia, which belong to the order actinomycetales. If they can affect immunocompetent adult, nocardioses are pathologies affecting the individuals with weakened immune system. Pulmonary involvement is the most common manifestation, its correct management is based on diagnosis, which is often delayed due to non-specific symptoms and inconclusive specimens. We here report two cases of nocardiosis in immunocompetent patients. The first case concerns a 24-year old man with a history of smoking and alcoholism, hospitalized for chest pain and hemoptysis of low abundance evolving for two months, associated with the occurrence of dorsal subcutaneous fistulized abscess...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903179/antinociceptive-anti-inflammatory-and-anxiolytic-like-effects-of-the-ethanolic-extract-fractions-and-hibalactone-isolated-from-hydrocotyle-umbellata-l-acari%C3%A3-oba-araliaceae
#11
Thiago Levi Silva Oliveira, Sandra Ribeiro de Morais, Stone de Sá, Matheus Gabriel de Oliveira, Iziara Ferreira Florentino, Dayane Moreira da Silva, Verônica Vale Carvalho, Vinícius Barreto da Silva, Boniek Gontijo Vaz, José Ricardo Sabino, Elson Alves Costa, José Realino de Paula
Hydrocotyle umbellata Linn. (Araliaceae) is specie used in the treatment of inflammatory diseases. Crude extract (E-HU) was prepared from H. umbellata subterraneous parts and fractionated by liquid-liquid partition, resulting hexane fraction (HF-HU), dichloromethane fraction (DF-HU), ethyl acetate fraction (EAF-HU) and aqueous fraction (AF-HU). The hibalactone (HU-1) was isolated from the DF-HU and its structure was elucidated by (1)H NMR and (13)C NMR Spectroscopy, mass spectrometry and crystallographic x-ray analysis...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28890718/transmembrane-tumor-necrosis-factor-controls-myeloid-derived-suppressor-cell-activity-via-tnf-receptor-2-and-protects-from-excessive-inflammation-during-bcg-induced-pleurisy
#12
Leslie Chavez-Galan, Dominique Vesin, Husnu Uysal, Guillaume Blaser, Mahdia Benkhoucha, Bernhard Ryffel, Valérie F J Quesniaux, Irene Garcia
Pleural tuberculosis (TB) is a form of extra-pulmonary TB observed in patients infected with Mycobacterium tuberculosis. Accumulation of myeloid-derived suppressor cells (MDSC) has been observed in animal models of TB and in human patients but their role remains to be fully elucidated. In this study, we analyzed the role of transmembrane TNF (tmTNF) in the accumulation and function of MDSC in the pleural cavity during an acute mycobacterial infection. Mycobacterium bovis BCG-induced pleurisy was resolved in mice expressing tmTNF, but lethal in the absence of tumor necrosis factor...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28858765/1-aryl-1h-and-2-aryl-2h-1-2-3-triazole-derivatives-blockade-p2x7-receptor-in%C3%A2-vitro-and-inflammatory-response-in%C3%A2-vivo
#13
Daniel Tadeu Gomes Gonzaga, Leonardo Braga Gomes Ferreira, Thadeu Estevam Moreira Maramaldo Costa, Natalia Lidmar von Ranke, Paulo Anastácio Furtado Pacheco, Ana Paula Sposito Simões, Juliana Carvalho Arruda, Luiza Pereira Dantas, Hércules Rezende de Freitas, Ricardo Augusto de Melo Reis, Carmen Penido, Murilo Lamim Bello, Helena Carla Castro, Carlos Rangel Rodrigues, Vitor Francisco Ferreira, Robson Xavier Faria, Fernando de Carvalho da Silva
Fifty-one 1,2,3-triazole derivatives were synthesized and evaluated with respect to P2X7 receptor (P2X7R) activity and its associated pore. These triazoles were screened in vitro for dye uptake assay and its cytotoxicity against mammalian cell types. Seven 1,2,3-triazole derivatives (5e, 6e, 8h, 9d, 9i, 11, and 12) potently blocked P2X7 receptor pore formation in vitro (J774.G8 cells and peritoneal macrophages). All blockers displayed IC50 value inferior to 500 nM, and they have low toxicity in either cell types...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28844678/antioxidant-anti-inflammatory-antiproliferative-and-antimycobacterial-activities-of-the-essential-oil-of-psidium-guineense-sw-and-spathulenol
#14
Kamilla Felipe do Nascimento, Flora Martinez Figueira Moreira, Joyce Alencar Santos, Candida Aparecida Leite Kassuya, Julio Henrique Rosa Croda, Claudia Andrea Lima Cardoso, Maria do Carmo Vieira, Ana Lúcia Tasca Góis Ruiz, Mary Ann Foglio, João Ernesto de Carvalho, Anelise Samara Nazari Formagio
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity. AIM OF THE STUDY: To evaluate the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of P. guineense and spathulenol (a major constituent). The study was conducted in part to provide evidence supporting the ethnobotanical use of the leaves of this species...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28798953/the-ethanolic-stem-bark-extract-of-antrocaryon-micraster-inhibits-carrageenan-induced-pleurisy-and-pedal-oedema-in-murine-models-of-inflammation
#15
Leslie B Essel, David D Obiri, Newman Osafo, Aaron O Antwi, Babatunde M Duduyemi
We investigated the antioxidant and anti-inflammatory effects of a 70% v/v ethanol extract of the stem bark of Antrocaryon micraster on murine models of carrageenan-induced pleurisy and paw oedema. Rat pleural fluid was analysed for volume, protein content, and leucocytes, while lung histology was assessed for damage. Lung tissue homogenates were assayed for glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO). Phytochemical analysis was carried out on the stem bark...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28797003/pleural-effusion-in-multiple-myeloma-characteristics-and-practice-patterns
#16
Ja Min Byun, Ki Hwan Kim, In Sil Choi, Jin Hyun Park, Jin-Soo Kim, Dong-Yeop Shin, Youngil Koh, Inho Kim, Sung-Soo Yoon, Hyo Jeong Lim
In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Among 575 MM patients diagnosed during the study period, 80 (13.9%) that were associated with PE were identified and analyzed...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28795307/sex-symptom-severity-and-quality-of-life-in-rheumatology
#17
REVIEW
Marco Krasselt, Christoph Baerwald
Inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) show a striking female predominance ranging from 3:1 in RA up to 9:1 in SLE. The background for those gender bias is not fully understood yet, but seems to be the result of a complex interaction between sex hormones, (epi-)genetics, and possibly even the composition of gut microbiota. Moreover, time of disease onset, the clinical phenotype including co-morbidities as well as the course of the diseases during life differ between genders...
August 9, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28748883/epidemiology-and-outcome-of-tuberculosis-in-immunocompromised-patients
#18
Abdul Massiah Metry, Issa Al Salmi, Seif Al-Abri, Faisal Al Ismaili, Yaqoub Al Mahrouqi, Alan Hola, Faissal A M Shaheen
The United States Renal Data System showed 1.2% and 1.6% incidences of tuberculosis (TB) in patients on peritoneal dialysis and hemodialysis (HD), respectively. Kidney transplant (KTX) patients have higher rates. We studied the epidemiology and outcome of TB in patients with kidney dysfunction in a tertiary care hospital in the past decade. We examined data of patients with TB with and without kidney dysfunction from 2006 to 2015 through an electronic system. Statistical analysis was completed using Stata software, Chicago, IL, USA...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28746225/ulcerative-colitis-with-acute-pleurisy-a-case-report-and-review-of-the-literature
#19
REVIEW
Shuming Lu, Lihua Wang, Weisheng Zhang, Zhuqing Zhang, Lina Liu, Yingde Wang, Hua Meng
RATIONALE: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number of extraintestinal manifestations. Pulmonary manifestations are infrequently seen in patients with IBD. Moreover, serositis including pleural and pericardial manifestations in UC is rare. PATIENT CONCERNS: We report a case of UC with acute pleurisy in a 43-year-old man; review literature; and discuss the diagnosis, differential diagnosis, and treatment...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28731666/pulmonary-complications-of-chemical-pneumonia-a-case-report
#20
Semiha Bahceci Erdem, Hikmet T Nacaroglu, Rana Isgüder, Canan S Unsal Karkiner, Hüdaver Alper, Demet Can
Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner...
August 1, 2017: Archivos Argentinos de Pediatría
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