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Namrita Lall, Vivek Kumar, Debra Meyer, Nomasomi Gasa, Chris Hamilton, Motlalepula Matsabisa, Carel Oosthuizen
ETHNOPHARMACOLOGICAL RELEVANCE: The Natal gwarri or Natal ebony (Euclea natalensis A.DC.) is a deciduous tree found widespread throughout southern Africa, especially in Kwazulu-Natal and the southern cost. It has been widely used by indigenous communities such as the Zulus, Tsongas and Vendas for symptoms related to tuberculosis (TB). The decoctions made from the plant parts are administered for chest diseases to treat complications such as chest pains, bronchitis, pleurisy and asthma...
October 20, 2016: Journal of Ethnopharmacology
Ming-Qiu Shan, Yan Qian, Sheng Yu, Shu-Chen Guo, Li Zhang, An-Wei Ding, Qi-Nan Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Schizonepeta tenuifolia Briq. (ST) herbs have been used as a Traditional Chinese Medicine (TCM) for treating colds for thousands of years. The volatile oil is considered as the main material basis responsible for the efficacy of ST and has attracted lots of attention on its anti-inflammatory effect recently. AIM OF STUDY: This paper investigated the anti-inflammatory effects of the distilled volatile oils from Schizonepeta tenuifolia (STVO) that were collected at different harvesting times on carrageenin-induced pleurisy in rats...
October 17, 2016: Journal of Ethnopharmacology
Atsushi Hata, Hidemi Suzuki, Takahiro Nakajima, Kazuhisa Tanaka, Taiki Fujiwara, Hironobu Wada, Takekazu Iwata, Shigetoshi Yoshida, Ichiro Yoshino
BACKGROUND: Lung carcinoma is often associated with interstitial lung disease (ILD), and the prognosis of lung cancer accompanied by ILD is unfavorable. In this study, cases of patients with primary lung cancer with or without ILD were reviewed to analyze surgical outcome, with special interest in the conformity of clinical and pathologic stages, pathologic findings of pleural invasion, malignant pleurisy first detected at the time of thoracotomy, and survival. METHODS: Retrospective chart review was performed for 1,264 primary lung cancer patients who underwent surgery from 2004 to 2015...
October 17, 2016: Annals of Thoracic Surgery
Ulku Aka Akturk, Dilek Ernam, Makbule Ozlem Akbay, Nagihan Durmus Koçak, Erhan Ogur, Ilim Irmak
OBJECTIVES: Pleural effusion is a common diagnostic and clinical problem. The differential diagnosis of pleural effusion may be difficult and may require several procedures, including invasive ones. Certain studies have investigated biochemical parameters to facilitate the diagnosis of exudative pleural effusion; however, it remains a challenging problem in clinical practice. We aimed to investigate the potential role of the neutrophil-lymphocyte ratio, which can be easily obtained by determining the cell count of the pleural fluid, in the differential diagnosis of exudative pleural effusion...
October 1, 2016: Clinics
Ari Polachek, Dafna D Gladman, Jiandong Su, Murray B Urowitz
OBJECTIVES: To define and identify a group of SLE patients with low disease activity (LDA) and to examine whether it is similar to patients in remission and different from a high disease activity group (HDA) in short term outcomes. METHODS: LDA group was defined as Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) <3 including only 1 clinical manifestation of: rash, alopecia, mucosal ulcers, pleurisy, pericarditis, fever, thrombocytopenia or leukopenia...
October 1, 2016: Arthritis Care & Research
Yuzo Suzuki, Masahiro Shirai, Kazuhiro Asada, Seiichi Miwa, Masato Karayama, Yutaro Nakamura, Naoki Inui, Toshihiro Shirai, Hiroshi Hayakawa, Satoshi Baba, Takafumi Suda
RATIONALE: Tuberculosis (TB) is a leading cause of death among infectious diseases worldwide. Accumulated knowledge has revealed that macrophages are deeply involved in the progression and pathogenesis of TB. We hypothesized that the evaluation of a macrophage activation marker may be useful in the diagnosis and assessment of pulmonary TB. OBJECTIVES: To examine the utility of the macrophage-activation marker sCD163 as a diagnostic tool and measure of disease severity for pulmonary TB and tuberculous pleurisy...
September 29, 2016: Annals of the American Thoracic Society
Renu Saigal, Rajat Bhargav, Laxmikant Goyal, Abhishek Agrawal, Pradeep Mital, Dileep Wadhwani
AIM: To study clinical and electrophysiological properties of peripheral neuropathy (PN) in systemic lupus erythematosus (SLE) and their association with disease activity parameters. METHODS: A hospital-based observational study done among 50 SLE patients after informed consent. History and clinical examination including a detailed neurological examination was carried out. Blood and urine investigation were done and modified SLE disease activity index (SLEDAI)-2000 score was calculated...
December 2015: Journal of the Association of Physicians of India
Amar Singh, Anant Mohan, Aprajit B Dey, Dipendra K Mitra
BACKGROUND: Optimal T cell activation is vital for the successful resolution of microbial infections. Programmed death-1 (PD-1) is key immune checkpoint receptor expressed by activated T cells. Aberrant/excessive inhibition mediated by PD-1 may impair host immunity to M. tuberculosis infection, leading to disseminated disease like miliary tuberculosis (MTB). PD-1 mediated inhibition of T cells in pulmonary tuberculosis and TB pleurisy is reported. However, their role in MTB, particularly at the pathologic sites remains to be addressed...
September 26, 2016: Clinical and Experimental Immunology
Huijun Zhang, Zenghui Lu
This is a case report of spinal tuberculosis combined with sacroiliac joint tuberculosis, pulmonary tuberculosis, chest wall tuberculosis and tuberculous pleurisy and the image of the patient is rare, special and not typical and it looks like a halo sign. It has an important reference value for the diagnosis of spine tuberculosis although it is a rare imaging manifestation and diagnosis was confirmed by pathology after the surgery. Therefore atypical imaging is often appeared in clinical practice and it is meaningful and necessary for the diagnosis of atypical spinal tuberculosis combined with multiple organ tuberculosis...
2016: Pan African Medical Journal
Adriana Lama, Lucía Ferreiro, María E Toubes, Antonio Golpe, Francisco Gude, José M Álvarez-Dobaño, Francisco J González-Barcala, Esther San José, Nuria Rodríguez-Núñez, Carlos Rábade, Carlota Rodríguez-García, Luis Valdés
BACKGROUND: Pseudochylothorax (PCT) (cholesterol pleurisy or chyliform effusion) is a cholesterol-rich pleural effusion (PE) that is commonly associated with chronic inflammatory disorders. Nevertheless, the characteristics of patients with PCT are poorly defined. METHODS: A systematic review was performed across two electronic databases searching for studies reporting clinical findings, PE characteristics, and the most effective treatment of PCT. Case descriptions and retrospective studies were included...
August 2016: Journal of Thoracic Disease
Lucas Noboru Fatori Trevizan, Kamilla Felipe do Nascimento, Joyce Alencar Santos, Candida Aparecida Leite Kassuya, Claudia Andrea Lima Cardoso, Maria do Carmo Vieira, Flora Martinez Figueira Moreira, Julio Croda, Anelise Samara Nazari Formagio
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk. (Sapindaceae) are traditionally used as a natural anti-inflammatory agent; however, there are no scientific studies demonstrating its activity essential oil. The content of essential oil in A. edulis may be the chemical basis to explain its ethnobotanical uses, since infusions of this plant are used to treat inflammation in the traditional medicine in Brazil. AIM OF THE STUDY: This study evaluated the anti-inflammatory, antioxidant and anti-mycobacterial activities of the essential oil (EOAE) and viridiflorol, its main compound...
November 4, 2016: Journal of Ethnopharmacology
C Grozavu, A Fera, M Iliaş, D Pantile
INTRODUCTION: Bronchogenic cysts, commonly located in the mediastinum or lung parenchyma, arise from abnormal budding of the tracheobronchial tree. Since an unknown percentage of asymptomatic adult patients with bronchogenic cysts remain undiagnosed, the true natural history ofthese cysts in adults is uncertain and the available series reflect a significant selection bias in favor of the symptomatic individual. CASE REPORT: We present the case of a 42-year-old female who presented with adull central chest pain, which gradually worsened overseveral weeks...
July 2016: Chirurgia
Kana Hashimoto, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima
BACKGROUND: Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5-10 % of cases. It has a poor prognosis, with direct invasion of the chest wall or lungs and distant metastases. Its pathological characteristics include dense collagen fibers in a storiform pattern. Its pretreatment pathological diagnosis is difficult, with fibrous pleuritis and reactive mesothelial hyperplasia as potential differential diagnoses...
2016: BMC Cancer
Amanda F Cidade, Patrícia A Vasconcelos, Daiany P B Silva, Iziara F Florentino, Géssica A Vasconcelos, Boniek G Vaz, Elson A Costa, Luciano M Lião, Ricardo Menegatti
Inflammatory diseases and pain are among the main problems that significantly influence the lifestyle of millions of people and existing therapies are not always effective and can cause several adverse effects. In this context, the molecular modifications or synthesis of compounds continue being the best strategies for the identification of new compounds for the treatment of pain and inflammation. The aim of this study was to evaluate the analgesic and anti-inflammatory activities of new analogues of pyrazole compounds containing subunits N-phenyl-1-H-pirazoles and 1,3,4-oxadiazole-2(3H)-thione, LQFM-146, LQFM-147 and LQFM-148...
August 30, 2016: European Journal of Pharmacology
Heni Rachmawati, Dewi Safitri, Aditya Trias Pradana, I Ketut Adnyana
Curcumin, a hydrophobic polyphenol compound derived from the rhizome of the Curcuma genus, has a wide spectrum of biological and pharmacological applications. Previously, curcumin nanoparticles with different stabilizers had been produced successfully in order to enhance solubility and per oral absorption. In the present study, we tested the anti-inflammatory effect of d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized curcumin nanoparticles in vivo. Lambda-carrageenan (λ-carrageenan) was used to induce inflammation in rats; it was given by an intraplantar route and intrapelurally through surgery in the pleurisy test...
August 16, 2016: Pharmaceutics
Lanussy Porfiro de Oliveira, Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, James Oluwagbamigbe Fajemiroye, Thiago Sardinha de Oliveira, Renato Ivan de Ávila Marcelino, Francine Pazini, Luciano Morais Lião, Paulo César Ghedini, Soraia Santana de Moura, Marize Campos Valadares, Verônica Vale de Carvalho, Boniek Gontijo Vaz, Ricardo Menegatti, Elson Alves Costa
The molecular modification and synthesis of compounds is vital to discovering drugs with desirable pharmacological and toxicity profiles. In response to pyrazole compounds' antipyretic, analgesic, and anti-inflammatory effects, this study sought to evaluate the analgesic, anti-inflammatory, and vasorelaxant effects, as well as the mechanisms of action, of a new pyrazole derivative, 5-[1-(4-fluorphenyl)-1H-pyrazol-4-yl]-2H-tetrazole (FPPT). During the acetic acid-induced abdominal writhing test, treatments with FPPT reduced abdominal writhing, while during the formalin test, FPPT reduced licking times in response to both neurogenic pain and inflammatory pain, all without demonstrating any antinociceptive effects, as revealed during the tail flick test...
August 16, 2016: Chemical Biology & Drug Design
Yan Liang, Ying Wang, Hang Li, Yourong Yang, Jianyang Liu, Ting Yu, Xueqiong Wu
The study explored the use of IP-10, MCP-1, and IFN-γ as biomarkers to improve the diagnoses of active pulmonary tuberculosis and tuberculous pleurisy. We enrolled 267 individuals, including 134 TB patients, 93 patients with non-tuberculous pulmonary diseases, and 40 healthy controls. Whole bloods were stimulated in vitro with rCFP-10/ESAT-6 protein antigen of Mycobacterium tuberculosis. The levels of IFN-γ, IP-10, and MCP-1 in cultured supernatants of whole bloods were detected by a chemiluminescence immunoassay...
October 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Jiangping Li, Sifei Yu, Yannan Zhang, Juan Shen, Suihua Lao, Baiqing Li, Binyan Yang, Changyou Wu
Control of infection with Mycobacterium tuberculosis (M.tb) requires effective antigen-specific immune response, including CD4(+) and CD8(+) T-cell responses; however, the local immune response of mucosal-associated invariant T (MAIT) cells at the site of infection is unclear. MAIT cells are a prevalent and unique, innate T-cell population that expresses the semi-invariant T-cell receptor TCRVα7.2. Our direct ex vivo analysis demonstrates that the frequency of MAIT cells in pleural fluid was much higher than that in peripheral blood from healthy donors, but much lower than that in peripheral blood from patients with tuberculosis...
August 9, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Joon Young Choi, Sung-Hwan Kim, Seung-Ki Kwok, Jung Im Jung, Kyo-Young Lee, Tae-Jung Kim, Ji Young Kang
Behçet's disease is a systemic disease which may involve various organs. We describe a case of a patient diagnosed as pleuropericardial involvement of Behçet's disease. A 30-year-old woman visited our clinic presented with left pleuritic chest pain for s days. She had been diagnosed as Behçet's disease and admitted to our clinic due to pericardial and pleural effusion repeatedly in past two years. In the previous studies, effusion analysis revealed to be lympho-dominant exudate with high adenosine deaminase level...
July 2016: Journal of Thoracic Disease
Yanna C F Teles, Jaime Ribeiro-Filho, Patrícia T Bozza, Maria de Fátima Agra, Weam Siheri, John O Igoli, Alexander I Gray, Maria de Fátima V de Souza
This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α...
August 2016: Natural Product Research
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