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Jane A Shaw, Elvis M Irusen, Andreas H Diacon, Coenraad Fn Koegelenberg
Tuberculosis (TB) is the leading infectious cause of death worldwide, and the commonest cause of death in people living with HIV. Globally, pleural TB remains one of the most frequent causes of pleural exudates, particularly in TB-endemic areas and in the HIV positive population. Most TB pleural effusions are exudates with high adenosine deaminase (ADA), lymphocyte-rich, straw-coloured and free flowing, with a low yield on mycobacterial culture. TB pleurisy can also present as loculated neutrophil-predominant effusions which mimic parapneumonic effusions...
April 16, 2018: Clinical Respiratory Journal
Tomáš Soukup, Tomáš Veleta
Systemic sclerosis is classed as a diffuse (systemic) disease of connective tissue. It is a heterogeneous disease significantly shortening life expectancy. Its etiology is unknown. Pathogenetic interplay is assumed to involve a triad of pathological autoimmune inflammation, vasculopathy and fibrosis. Clinical manifestations can be classed based on the preponderant pathogenetic process. Vasculopathy is manifested by secondary Raynauds phenomenon with abnormal findings on the nailfold capillaroscopy, skin telangiectasias, gastric antral vascular ectasia, life threatening scleroderma renal crisis, digital ulcerations and prognostically severe pulmonary arterial hypertension...
2018: Vnitr̆ní Lékar̆ství
A Toleuova, D Tayzhanova, R Toyynbekova, Zh Beysenbekova
Fungal pneumonia is considered as one of the most serious forms of pneumonia, the number of which has recently increased despite the use of new antimycotic drugs in pulmonology. Specificity of pathogens and torpid current of pneumomycosis represent great difficulties for accurate diagnosis and delay the timely onset of therapy, exacerbating inflammatory changes. In this article we present a rare case of isolated infection of the lungs parenchyma with Candida albicans in the form of focal pneumonia of the right lung lower lobe complicated by a clotted pleurisy...
February 2018: Georgian Medical News
Fanny Pandolfi, Sandra A Edwards, Dominiek Maes, Ilias Kyriazakis
This study aimed to provide an overview of the interconnections between biosecurity, health, welfare, and performance in commercial pig farms in Great Britain. We collected on-farm data about the level of biosecurity and animal performance in 40 fattening pig farms and 28 breeding pig farms between 2015 and 2016. We identified interconnections between these data, slaughterhouse health indicators, and welfare indicator records in fattening pig farms. After achieving the connections between databases, a secondary data analysis was performed to assess the interconnections between biosecurity, health, welfare, and performance using correlation analysis, principal component analysis, and hierarchical clustering...
2018: Frontiers in Veterinary Science
Qing Liu, Yan-Xia Yu, Xiao-Juan Wang, Zheng Wang, Zhen Wang
BACKGROUND: The concentration assay of pleural effusion interleukin-27 (IL-27) has raised concern for diagnosing tuberculous pleurisy. Compared with malignant pleural effusion (MPE), the concentration of IL-27 in tuberculous pleural effusion (TPE) increased significantly. Accurate differentiating diagnosis is essential for choosing treatment for pleural effusion. OBJECTIVE: The present meta-analysis is aimed at determining the accuracy of IL-27 in the differential diagnosis between TPE and MPE...
March 14, 2018: Respiration; International Review of Thoracic Diseases
Atsushi Nagayasu, Satoshi Kubo, Kazuhisa Nakano, Shingo Nakayamada, Shigeru Iwata, Ippei Miyagawa, Shunsuke Fukuyo, Kazuyoshi Saito, Yoshiya Tanaka
An 81-year-old man was admitted with bilateral pleural effusion. A clinical examination showed lymphocytic pleura effusion and elevated serum IgG4 levels, so that IgG4-related disease was suggested, whereas tuberculous pleurisy was suspected because of high adenosine deaminase (ADA) levels in the pleural effusion. A surgical pleural biopsy revealed that there were large numbers of IgG4-positive cells and IgG4/IgG positive cell ratio exceeded 40% in several sites. Accordingly, we diagnosed IgG4-related pleuritis and treated with the patient with glucocorticoid therapy...
March 9, 2018: Internal Medicine
Xiao Zhang, Yi Sun, Caiyun He, Xiaofen Qiu, Dalei Zhou, Zulu Ye, Yakang Long, Tao Tang, Xuan Su, Jiangjun Ma
We aimed to assess the immunoregulatory effects of IFN-β in patients with tuberculous pleurisy. IFN-β, IFN-γ and IL-17 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid mononuclear cells (PFMCs) from tuberculous pleural effusions, but not peripheral blood mononuclear cells (PBMCs) from healthy donors, spontaneously expressed IFN-β, IL-17 and IFN-γ. Moreover, exogenous IFN-β significantly inhibited the expression of IL-17 in PFMCs...
March 5, 2018: Microbiology and Immunology
Silvia M S Sandes, Luana Heimfarth, Renan G Brito, Priscila L Santos, Daniele N Gouveia, Alexandra M S Carvalho, Jullyana S S Quintans, Edeildo F da Silva-Júnior, Thiago M de Aquino, Paulo H B França, João X de Araújo-Júnior, Ricardo L C Albuquerque-Júnior, Gokhan Zengin, Martine Schmitt, Jean-Jacques Bourguignon, Lucindo J Quintans-Júnior
BACKGROUND: Indole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine. METHODS: Mice were treated with LQM01 (5, 10, 25 or 50 mg/kg, i.p.), vehicle (0.9% saline i.p.) or a standard drug. The mice were subjected to carrageenan-induced pleurisy, abdominal writhing induced by acetic acid, the formalin test and the hot-plate test. The model of non-inflammatory chronic muscle pain induced by saline acid was also used...
April 25, 2018: Chemico-biological Interactions
John I Alawneh, Christopher R Parke, Eduardo J Lapuz, Jose E David, Voltaire G Basinang, Augusto S Baluyut, Tamsin S Barnes, Edwin C Villar, Minnie L Lopez, Joanne Meers, Patrick J Blackall
A cross-sectional study of lungs from 1,887 randomly selected pigs from 471 farms from two provinces in the Philippines was carried out to estimate the prevalence of gross pathological lesions, identify potential risk factors and spatial clustering associated with high lung or pleurisy score farms. Lungs from pigs were scored at slaughter. Interviews with the farm managers were conducted to collect information about farm management and biosecurity practices. Of lungs examined, 48% had a lung score above 6 (maximum was 55) and 22% showed pleurisy...
2018: Frontiers in Veterinary Science
Rongxia Li, Eric Weintraub, Michael M McNeil, Martin Kulldorff, Edwin M Lewis, Jennifer Nelson, Stanley Xu, Lei Qian, Nicola P Klein, Frank Destefano
PURPOSE: The objective of our study was to conduct a data mining analysis to identify potential adverse events (AEs) following MENACWY-D using the tree-temporal scan statistic in the Vaccine Safety Datalink population and demonstrate the feasibility of this method in a large distributed safety data setting. METHODS: Traditional pharmacovigilance techniques used in vaccine safety are generally geared to detecting AEs based on pre-defined sets of conditions or diagnoses...
February 15, 2018: Pharmacoepidemiology and Drug Safety
Sorin Claudiu Man, Valentina Sas, Cristina Schnell, Camelia Florea, Adelina Ţuţu, Ariana Szilágyi, Sergiu Belenes, Amalia Hebriştean, Anca Bonaţ, Claudia Cladovan, Cornel Aldea
Background and aims: Community-acquired pneumonia (CAP) is a both common and serious childhood infection. Antibiotic treatment guidelines help to reduce inadequate antibiotics prescriptions. Methods: We conducted a retrospective study at the Clinical Emergency Hospital for Children, 3rd Pediatric Clinic, Cluj-Napoca and Dr. Gavril Curteanu Clinical City Hospital, in Oradea. All patients discharged with a diagnosis of CAP between December 1, 2014 and February 28, 2015, were included in the study...
2018: Clujul Medical (1957)
Mako Yamoto, Yukio Kawagishi, Akari Murata, Hiroshi Tsuji
We report two cases of pleurisy caused by non-tuberculous mycobacteria followed by pneumothorax. The onset of pleurisy was accompanied by acute fever. Cultured samples of the pleural effusions from the two patients, an 80-year-old man and an 87-year-old woman, were ultimately found to contain Mycobacterium intracellulare and Mycobacterium kansasii , respectively. Both patients were initially administered antibiotics, but their fevers persisted. Therefore, different combinations of antimycobacterial drugs were used, which reduced the fever in a few days...
February 8, 2018: BMJ Case Reports
Isano Hase, Kazuhiro Kurasawa, Hidenori Takizawa, Bunpei Yamaguchi, Hideo Sakuma, Yoshiki Ishii
Yellow nail syndrome (YNS) pleurisy is often difficult to control, and pathological examinations have rarely been reported. We herein report a case of bucillamine-induced YNS in which histopathology of the parietal pleura revealed hyperplasia of the lymphoid follicles and lymphangiectasia. Even after the discontinuation of bucillamine, the pleurisy and lymphedema showed no change. Based on the histopathological findings showing similarity to rheumatoid pleurisy, we administered corticosteroid treatments, and both the pleurisy and lymphedema improved...
February 9, 2018: Internal Medicine
Meng Zhang, Dedong Xiong, Hongxia Li, Zonglan Wang, Renzhe Li
The purpose of the present study was to investigate the diagnostic value of T cells spot test (T-Spot TB) combined with interferon-γ (INF-γ) and interleukin-27 (IL-27) in tuberculous pleurisy. Sixty patients with tuberculous pleurisy (observation group) and 60 patients with non-tuberculous pleurisy (control group) were enrolled in this study. T-Spot TB was performed to detect the pleural effusion of two groups of patients. Levels of IFN-γ and IL-27 in serum and pleural effusion were detected by enzyme-linked immunosorbent assay (ELISA)...
February 2018: Experimental and Therapeutic Medicine
Tomoo Inoue, Atsushi Shimomura, Takuji Sugimoto, Shiori Wakamiya, Ukou Chou, Akira Fujiwara, Fumihiro Uchikoshi, Tarou Watanabe, Natsuko Kitamura
This study reports the treatment and local control of advanced breast cancer with a giant ulcer. A 53-year-old woman presented with a large left breast tumor and an associated giant ulcer, with massive exudates, bleeding, and an offensive odor. Histopathological examination revealed an invasive ductal carcinoma(Luminal B type). Computed tomography(CT) showed multiple metastases to the lymph nodes, lungs, liver and bones. The patient received chemotherapy with a combina- tion of paclitaxel(PTX 90mg/m / 2)and bevacizumab(BEV 10 mg/kg)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Min Li, Wenye Zhu, Rana Sami Ullah Khan, Ummair Saeed, Rongchun Wang, Shaoqing Shi, Zhuang Luo
BACKGROUND: The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE. METHODS: Primary diagnostic test studies of IL-27 for TPE was searched and identified from databases...
December 2017: Medicine (Baltimore)
Han-Yan Xu, Cheng-Ye Li, Shan-Shan Su, Li Yang, Min Ye, Jun-Ru Ye, Pei-Pei Ke, Cheng-Shui Chen, Yu-Peng Xie, Yu-Ping Li
The aim of this study was to identify the optimal cut-off value of T cell enzyme-linked immunospot assay for tuberculosis (T-SPOT.TB) and evaluate its diagnostic performance alone (in the peripheral blood) or in combination with the adenosine deaminase (ADA) activity test (in peripheral blood and the pleural fluid) in patients with tuberculous pleurisy.Adult patients presenting with pleural effusion were included in this prospective cohort study. Tuberculous pleurisy was diagnosed by T-SPOT.TB in peripheral blood and a combination of T-SPOT...
November 2017: Medicine (Baltimore)
Joke Leemans, Christophe Dooms, Vincent Ninane, Jonas Yserbyt
BACKGROUND AND OBJECTIVE: Malignant pleurisy is associated with advanced oncological disease and dyspnoea is the most common presenting symptom. Pleurodesis is the preferred palliative and supportive treatment option, targeting symptom relief. The identification of clinical and endoscopic features that determine the success of talc pleurodesis in malignant pleurisy could guide clinical decision-making. METHODS: All symptomatic patients with malignant pleurisy subjected to talc pleurodesis through medical thoracoscopy between January 2012 and December 2015 were included...
January 10, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Edmund Ekuadzi, Robert P Biney, Charles K Benneh, Bismark Osei Amankwaa, Jonathan Jato
This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M. discoidea and X. aethiopica are plants native in Ghana and the West-African region and used traditionally to treat different pathologies including inflammatory conditions. The antiinflammatory effect of BA and XA was established by an in vivo assay using the carrageenan-induced pleural inflammation model in mice. Also, the ability of BA and XA to increase catalase, superoxide dismutase, glutathione levels and decrease lipid peroxidation level in reactive oxidative assays was assessed...
March 2018: Phytotherapy Research: PTR
Ourania S Kotsiou, Panagiota Tzortzi, Rafailia A A Beta, Athanasios Kyritsis, Konstantinos I Gourgoulianis
BACKGROUND: A follow-up thoracentesis is proposed in suspected atypical tuberculosis cases. The study aimed to define the variability of pleural ADA values across repeated thoracenteses in different types of pleural effusions (PEs) and to evaluate whether ADA variance, in regard to the cutoff value of 40 U/L, affected final diagnosis. METHODS: A total of 131 patients with PEs of various etiologies underwent three repeated thoracenteses. ADA values were subsequently estimated...
December 7, 2017: Journal of Clinical Laboratory Analysis
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