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https://www.readbyqxmd.com/read/28512556/pediatric-tuberculosis-in-northern-sardinia
#1
Maria Grazia Clemente, Elena Dore, Lidia Abis, Paola Molicotti, Stefania Zanetti, Paolina Olmeo, Roberto Antonucci
BACKGROUND AND OBJECTIVES: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor. DESIGN: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28480389/evaluation-of-the-anti-inflammatory-capacity-of-beta-sitosterol-in-rodent-assays
#2
Rogelio Paniagua-Pérez, Gabriela Flores-Mondragón, Celia Reyes-Legorreta, Brígida Herrera-López, Isabel Cervantes-Hernández, Osiris Madrigal-Santillán, José Antonio Morales-González, Isela Álvarez-González, Eduardo Madrigal-Bujaidar
BACKGROUND: Beta-sitosterol (BS) is a compound discovered to be present in numerous plants. A number of interesting biomedical properties have been attributed to BS, including immuno-modulating and anti-inflammatory activities. Therefore, the aim of this report was to evaluate its anti-inflammatory capacity by applying various rodent experimental tests. METHODS: To carry out the objective of the study we applied the methods indicated here. Two of the adopted methods were based on the passive reverse Arthus reaction: the rat paw edema test and the rat pleurisy assay...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28461340/inhibition-of-inflammasome-activation-improves-lung-acute-injury-induced-by-carrageenan-in-a-mouse-model-of-pleurisy
#3
Roberta Fusco, Enrico Gugliandolo, Flavia Biundo, Michela Campolo, Rosanna Di Paola, Salvatore Cuzzocrea
The inflammasome NLRP3 is a molecular pathway activated by a wide range of cellular insults to elicit innate immune defenses through the activation of caspase-1 and the maturation of proinflammatory cytokines, such as IL-1β and IL-18. The expression of NRLP3 is abnormally elevated in numerous human inflammatory diseases, including pulmonary diseases. An injection of carrageenan (CAR) into the pleural cavity triggered an acute inflammatory response, leading to tissue damage, inflammatory exudates, leukocyte infiltration, and increased myeloperoxidase activity...
May 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28460230/peripheral-blood-mononuclear-cells-from-rat-model-of-pleurisy-the-effects-of-hesperidin-on-ectoenzymes-activity-apoptosis-cell-cycle-and-reactive-oxygen-species-production
#4
Stephen Adeniyi Adefegha, Daniela Bitencourt Rosa Leal, Pedro Henrique Doleski, Pauline Christ Ledur, Assis Ecker
The present study investigates the effect of hesperidin; a flavonone commonly found in citrus fruits, on the ectoenzymes (ectonucleotidase and ecto-adenosine deaminase) activity, cell viability, apoptosis, cell cycle arrest and reactive oxygen species production in peripheral blood mononuclear cells (PBMCs) from rat model of pleurisy. Wistar rats were pretreated with either saline or hesperidin (80mg/kg) by oral gavage for 21days and injected intrapleurally with 2% carrageenan or saline on the 22nd day. PBMCs were subsequently prepared after 4h of carrageenan induction...
April 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28452739/-experimental-model-and-currency-of-experiment-of-distant-results-of-lead-exposition
#5
G Pataraia, T Bagashvili, G Andronikashvili, T Gurashvili, K Gogeshvili, M Avalishvili
In order to explore the distant results of exposition of little doses of lead, for the objective of the experiment model we have selected 32 mongral rats, of different age, but aged of both sex. Experimental animals were divided in two groups. During first two month from the beginning of the experiment, together with permissible food, animals were given the water, in which was open Pb(NO3)2 - to first group 1.5 mg on kg/weight and to II group 15 mg on kg/weight during the day and night. Before the beginning of the experiment, in the time of process and after it, observation was conducted, description and collection of photo-video materials about the behavior of animals, physiological parameters, possible change of weight, clear-sighted changes in appearance...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28451022/-pleuropulmonary-metastases-originating-from-extra-thoracic-neoplasia
#6
Farid Badri, Salma Ait Batahar, Safae El Idrissi, Hafsa Sajiai, Hind Serhane, Lamyae Amro
The lungs receive the entire venous drainage of the body. This explains the high incidence of pleuropulmonary metastases originating from several cancers. The goal of this is to study the clinical manifestations of pleuro-pulmonary metastases originating from extra-thoracic cancers. We conducted a retrospective study of patients with pleuro-pulmonary metastasis whose data were collected in our department between January 2006 and december 2014. 76 patient medical records were studied. The average age was 50 years (aged 21-89 years) with a male predominance in 57...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28420071/pleuropulmonary-involvement-in-patients-with-systemic-lupus-erythematosus-from-a-latin-american-inception-cohort-gladel
#7
M J Haye Salinas, F Caeiro, V Saurit, A Alvarellos, D Wojdyla, H R Scherbarth, A C de O E Silva, J C Tavares Brenol, L T Lavras Costallat, O J Neira, A Iglesias Gamarra, G Vásquez, G A Reyes Llerena, L A Barile-Fabris, L H Silveira, M J Sauza Del Pozo, E M Acevedo Vásquez, J L Alfaro Lozano, M H Esteva Spinetti, G S Alarcón, B A Pons-Estel
Objectives The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients. Materials and methods The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28412475/potential-anti-inflammatory-effect-of-lqfm-021-in-carrageenan-induced-inflammation-the-role-of-nitric-oxide
#8
Iziara F Florentino, Daiany P B Silva, Dayane M Silva, Carina Sofia Cardoso, André L E Moreira, Clayton L Borges, Célia M de A Soares, Pablinny M Galdino, Luciano M Lião, Paulo C Ghedini, Ricardo Menegatti, Elson A Costa
The pyrazole compound LQFM-021 exhibits vasorelaxant, antinociceptive and anti-inflammatory activities. Furthermore, it has low toxicity, indicating that this compound may be considered to be a good prototype for the development of new analgesic/anti-inflammatory drugs. Therefore, the aim of this study was to investigate the potential anti-inflammatory activity of LQFM-021 using a model of carrageenan-induced inflammation as well as the mechanism of action and role of nitric oxide in this effect. Acute treatments with LQFM-021 (30 and 60 mg/kg p...
April 12, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28410823/the-case-for-performing-pleural-biopsies-for-the-aetiological-diagnosis-of-exudates-yes
#9
F Rodriguez-Panadero
Pleural biopsies are especially indicated in the following circumstances: a) inconclusive pleural fluid analysis and negative sputum study, if adenosine deaminase (ADA) levels are unavailable; b) suspected multi-resistant tuberculosis; c) a need for differentiating tuberculous pleurisy (if it progresses with neutrophilia) and complicated parapneumonic effusion; d) malignant pleural effusion coexisting with very high ADA levels; e) effusion coexisting with lung cancer and negative pleural cytology; f) suspected mesothelioma; and g) need for implementing re-treatment for patients with relapse after chemotherapy...
April 12, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28386290/analgesic-and-anti-inflammatory-activities-of-resveratrol-through-classic-models-in-mice-and-rats
#10
Guangxi Wang, Zhiqiang Hu, Xu Song, Qiankun Cui, Qiuting Fu, Renyong Jia, Yuanfeng Zou, Lixia Li, Zhongqiong Yin
Background. Inflammation and pain are closely related to humans' and animals' health. Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28364381/adalimumab-with-methotrexate-in-treatment-na%C3%A3-ve-japanese-patients-with-rheumatoid-arthritis-at-risk-of-progressive-structural-joint-damage-a-postmarketing-observational-study
#11
Yukiko Ito, Kaori Hozumi, Yukiko Okada, Sarina Kurimoto
INTRODUCTION: The objective of this study was to evaluate the real-world safety and effectiveness of adalimumab with methotrexate (MTX) in disease-modifying antirheumatic drug (DMARD)- and biologic-naïve Japanese patients with rheumatoid arthritis (RA) at risk of progressive structural joint damage. METHODS: This multicenter, prospective, observational, postmarketing surveillance study was conducted between February 2013 and April 2015 at 84 centers in Japan. Patients with RA at risk of progressive structural joint damage were enrolled and initiated treatment with adalimumab and MTX...
March 31, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28362977/anti-inflammatory-effects-of-essential-oils-from-mangifera-indica
#12
R M Oliveira, T S Dutra, E Simionatto, N Ré, C A L Kassuya, C A L Cardoso
Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. Twenty-three volatile compounds were identified via gas chromatography-mass spectrometry (GC-MS) in two essential oils from the leaves. Paw edema and myeloperoxidase (MPO) activity were evaluated using the carrageenan-induced paw model, while leukocyte migration was analyzed using the pleurisy model...
March 16, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28335760/midkine-is-a-potential-novel-marker-for-malignant-mesothelioma-with-different-prognostic-and-diagnostic-values-from-mesothelin
#13
Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima, Masatoshi Tagawa, Muzaffer Metintas
BACKGROUND: We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. METHODS: Serum mesothelin and midkine levels were determined with an enzyme-linked immunosorbent assay. We examined specimens from 95 Turkish cases with malignant pleural mesothelioma, 56 metastatic cancers to pleura, 27 other types of benign pleural diseases and 20 benign asbestos pleurisy...
March 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28317818/erratum-evaluation-of-different-laboratory-methods-for-rapid-diagnosis-of-tuberculous-pleurisy
#14
(no author information available yet)
[This corrects the article DOI: 10.1016/j.ijmyco.2016.07.001.].
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28304239/immunoglobulin-g4-related-epidural-inflammatory-pseudotumor-presenting-with-pulmonary-complications-and-spinal-cord-compression-case-report
#15
Kavelin Rumalla, Kyle A Smith, Paul M Arnold
Immunoglobulin G4-related disease (IgG4-RD) is a recently defined condition characterized by inflammatory tumefactive lesions in various organ systems. IgG4-RD is a clinical and radiological diagnosis of exclusion and requires the presence of specific histopathological criteria for diagnosis. A 50-year-old man presented to an outside hospital with a 3-month history of progressively worsening back pain and symptoms of pleurisy, nasal crusting, and hematochezia. Radiological workup revealed an epidural-paraspinal mass with displacement of the spinal cord, destruction of the T5-6 vertebrae, and extension into the right lung...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28290161/corticosteroids-for-tuberculous-pleurisy
#16
REVIEW
Hannah Ryan, Jinho Yoo, Padmapriya Darsini
BACKGROUND: Corticosteroids used in addition to antituberculous therapy have been reported to benefit people with tuberculous pleurisy. However, research findings are inconsistent and raise doubt as to whether such treatment is worthwhile. There is also concern regarding the potential adverse effects of corticosteroids, especially in HIV-positive people. OBJECTIVES: To evaluate the effects of adding corticosteroids to drug regimens for tuberculous pleural effusion...
March 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28284315/long-term-outcome-of-patients-with-nonspecific-pleurisy-at-medical-thoracoscopy
#17
Yuan Yang, Yan-Bing Wu, Zhen Wang, Xiao-Juan Wang, Li-Li Xu, Zhao-Hui Tong, Huan-Zhong Shi
BACKGROUND: Medical thoracoscopy is an effective and safe procedure for diagnosing pleural effusions of undetermined causes. But there are still a part of patients with pleural effusions were diagnosed as nonspecific pleurisy when no specific biopsy results were found after undergoing thoracoscopic biopsy. The long-term outcome of these patients is unclear, and anxieties about undiagnosed malignancy persist. METHODS: Between July 2005 and June 2014, medical thoracoscopy using the semi-rigid instrument was performed and pleural biopsy was taken in 833 patients with pleural effusions...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28282613/design-synthesis-and-evaluation-of-novel-feruloyl-donepezil-hybrids-as-potential-multitarget-drugs-for-the-treatment-of-alzheimer-s-disease
#18
Kris Simone T Dias, Cynthia T de Paula, Thiago Dos Santos, Isis N O Souza, Marina S Boni, Marcos J R Guimarães, Fernanda M R da Silva, Newton G Castro, Gilda A Neves, Clarice C Veloso, Márcio M Coelho, Ivo Souza F de Melo, Fabiana C V Giusti, Alexandre Giusti-Paiva, Marcelo L da Silva, Laurent E Dardenne, Isabella A Guedes, Letizia Pruccoli, Fabiana Morroni, Andrea Tarozzi, Claudio Viegas
A novel series of feruloyl-donepezil hybrid compounds were designed, synthesized and evaluated as multitarget drug candidates for the treatment of Alzheimer's Disease (AD). In vitro results revealed potent acetylcholinesterase (AChE) inhibitory activity for some of these compounds and all of them showed moderate antioxidant properties. Compounds 12a, 12b and 12c were the most potent AChE inhibitors, highlighting 12a with IC50 = 0.46 μM. In addition, these three most promising compounds exhibited significant in vivo anti-inflammatory activity in the mice paw edema, pleurisy and formalin-induced hyperalgesy models, in vitro metal chelator activity for Cu(2+) and Fe(2+), and neuroprotection of human neuronal cells against oxidative damage...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28275073/rapid-detection-of-cell-free-mycobacterium-tuberculosis-dna-in-tuberculous-pleural-effusion
#19
Nanying Che, Xinting Yang, Zichen Liu, Kun Li, Xiaoyou Chen
Tuberculous pleurisy is one of the most common types of extrapulmonary tuberculosis, but its diagnosis remains difficult. In this study, we report for the first time on the detection of cell-free Mycobacterium tuberculosis DNA in pleural effusion and an evaluation of a newly developed molecular assay for the detection of cell-free Mycobacterium tuberculosis DNA. A total of 78 patients with pleural effusion, 60 patients with tuberculous pleurisy, and 18 patients with alternative diseases were included in this study...
May 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28242648/identification-of-novel-chondroprotective-mediators-in-resolving-inflammatory-exudates
#20
Magdalena K Kaneva, Karin V Greco, Sarah E Headland, Trinidad Montero-Melendez, Prashant Mori, Kevin Greenslade, Costantino Pitzalis, Adrian Moore, Mauro Perretti
We hypothesized that exudates collected at the beginning of the resolution phase of inflammation might be enriched for tissue protective molecules; thus an integrated cellular and molecular approach was applied to identify novel chondroprotective bioactions. Exudates were collected 6 h (inflammatory) and 24 h (resolving) following carrageenan-induced pleurisy in rats. The resolving exudate was subjected to gel filtration chromatography followed by proteomics, identifying 61 proteins. Fractions were added to C28/I2 chondrocytes, grown in micromasses, ions with or without IL-1β or osteoarthritic synovial fluids for 48 h...
April 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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