keyword
MENU ▼
Read by QxMD icon Read
search

Silk

keyword
https://www.readbyqxmd.com/read/29792681/protein-based-electronic-skin-akin-to-biological-tissues
#1
Minsik Jo, Kyungtaek Min, Biswajit Roy, Sookyoung Kim, Sangmin Lee, Ji-Yong Park, Sunghwan Kim
Human skin provides an interface that transduces external stimuli into electrical signals for communication with the brain. There has been considerable effort to produce soft, flexible, and stretchable electronic skin (E-skin) devices. However, common polymers cannot imitate human skin perfectly due to their poor biocompatibility, biofunctionality, and permeability to many chemicals and biomolecules. Herein, we report on highly flexible, stretchable, conformal, molecule-permeable, and skin-adhering E-skins that combine a metallic nanowire (NW) network and silk protein hydrogel...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791566/cytidine-phosphate-guanosine-oligodeoxynucleotides-in-combination-with-cd40-ligand-decrease-periodontal-inflammation-and-alveolar-bone-loss-in-a-tlr9-independent-manner
#2
Qian Zhao, Yang Hu, Shu Deng, Pei Yu, Bowen Chen, Zuomin Wang, Xiaozhe Han
Local administration of toll-like receptor 9 (TLR9), agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG ODNs), and CD40 ligand (CD40L) can decrease ligature-induced periodontal inflammation and bone loss in wild type (WT) mouse. OBJECTIVE: This study aimed to explore whether such effect is dependent on TLR9 signaling. MATERIAL AND METHODS: Purified spleen B cells isolated from WT C57BL/6J mice and TLR9 knockout (KO) mice were cultured for 48 hours under the following conditions: CD40L, CpG+CD40L, CpG at low, medium and high doses...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29791250/interview-the-new-silk-road-health-as-soft-power
#3
Ilona Kickbusch, Mustafa Bayram, Özgür Bayram, Nezih Hekim, Bülent Kayalı, Vural Özdemir
No abstract text is available yet for this article.
May 23, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29791031/ocean-acidification-stimulates-particulate-organic-carbon-accumulation-in-two-antarctic-diatom-species-under-moderate-and-high-natural-solar-radiation
#4
Jasmin P Heiden, Silke Thoms, Kai Bischof, Scarlett Trimborn
Impacts of rising atmospheric CO2 concentrations and increased daily irradiances from enhanced surface water stratification on phytoplankton physiology in the coastal Southern Ocean remain still unclear. Therefore, in the two Antarctic diatoms Fragilariopsis curta and Odontella weissflogii the effects of moderate and high natural solar radiation combined with either ambient or future pCO2 on cellular particulate organic carbon (POC) contents and photophysiology were investigated. Results showed that increasing CO2 concentrations had greater impacts on diatom physiology than exposure to increasing solar radiation...
May 23, 2018: Journal of Phycology
https://www.readbyqxmd.com/read/29790257/functionalized-silk-fibers-from-transgenic-silkworms-for-wound-healing-applications-surface-presentation-of-bioactive-epidermal-growth-factor
#5
Michael Wöltje, Melanie Böbel, Michaela Bienert, Sabine Neuss, Dilibaier Aibibu, Chokri Cherif
Growth factors play a crucial role in wound healing in general and are promising tools for the treatment of chronic wounds as they can restore the physiological wound healing process. In growth factor-loaded wound dressings, human epidermal growth factor (EGF) is released in a burst and washed out quickly. The developed matrix consists of recombinant EGF produced in transgenic silkworms as a fusion protein with the fibroin light chain. The covalent linkage prevents EGF from draining into the surrounding tissue while presenting the growth factor on the surface...
May 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29789802/successful-formulation-and-application-of-plant-growth-promoting-kosakonia-radicincitans-in-maize-cultivation
#6
Beatrice Berger, Sascha Patz, Silke Ruppel, Kristin Dietel, Sebastian Faetke, Helmut Junge, Matthias Becker
The global market for biosupplements is expected to grow by 14 percent between 2014 and 2019 as a consequence of the proven benefits of biosupplements on crop yields, soil fertility, and fertilizer efficiency. One important segment of biosupplements is plant growth-promoting bacteria (PGPB). Although many potential PGPB have been discovered, suitable biotechnological processing and shelf-life stability of the bacteria are challenges to overcome for their successful use as biosupplements. Here, the plant growth-promoting Gram-negative strain Kosakonia radicincitans DSM 16656T (family Enterobacteriaceae) was biotechnologically processed and applied in the field...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789336/illness-identity-a-novel-predictor-for-healthcare-use-in-adults-with-congenital-heart-disease
#7
Liesbet Van Bulck, Eva Goossens, Koen Luyckx, Leen Oris, Silke Apers, Philip Moons
BACKGROUND: To optimize healthcare use of adults with congenital heart disease, all important predictors of healthcare utilization should be identified. Clinical and psychological characteristics (eg, age and depression) have been found to be associated with healthcare use. However, the concept of illness identity, which assesses the degree to which congenital heart disease is integrated into one's identity, has not yet been investigated in association with healthcare use. Hence, the purpose of the study is to examine the predictive value of illness identity for healthcare use...
May 22, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29787338/learning-to-cope-with-mirror-movements-in-unilateral-spastic-cerebral-palsy-a-brief-report
#8
Caroline Adler, Melanie Hessenauer, Johanna Lipp, Silke Kunze, Carina Geigenberger, Andrea Hörning, Martina Schaudeck, Steffen Berweck, Martin Staudt
PURPOSE: Mirror movements (MM) in unilateral spastic cerebral palsy (USCP) interfere with many bimanual activities of daily living. METHODS: Here, we developed a specific bimanual therapeutic regimen, focusing on asymmetric simultaneous movements of the two hands. Twelve children (6-17 years old; complete data available in ten children) with USCP and MM were included. RESULTS: After three weeks of inpatient rehabilitation, we observed significant improvements for two self-defined bimanual goal activities (Goal Attainment Scaling, Canadian Occupational Performance Measure) and for bimanual performance in general (Assisting Hand Assessment)...
May 22, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29783766/finite-element-analysis-of-electrospun-nanofibrous-mats-under-biaxial-tension
#9
Yunlei Yin, Jie Xiong
Due to the non-uniform material properties of electrospun nanofibrous mats and the non-linear characteristics of single fibers, establishing a numerical model that can fully explain these features and correctly describe their properties is difficult. Based on the microstructure of electrospun nanofibrous mats, two macroscopic continuum finite element (FE) models with a uniform or oriented nanofiber distribution were established to describe the mechanical behavior of nanofibrous mats under biaxial tension. The FE models were verified by biaxial tension experiments on silk fibroin/polycaprolactone nanofibrous mats...
May 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783089/self-stabilized-silk-sericin-based-nanoparticles-in-vivo-biocompatibility-and-reduced-doxorubicin-induced-toxicity
#10
Doudou Hu, Ting Li, Zongpu Xu, Di Liu, Mingying Yang, Liangjun Zhu
A variety of colloid stabilizers and cryoprotectants confer improved nanoparticle (NP) colloidal stability and redisperability. However, the discounted tumor targetability, delivery efficacy and possible side effects limit the application in the vascular delivery of NPs. Here we present the water-soluble silk sericin (SS) not only as a material for the preparation of NPs, but also both a dispersion stabilizer and a cryoprotectant. In the absence of any stabilizers, SS-based NPs (SSC@NPs) could resist to the serum protein adsorption, preventing the formation of particle agglomerates...
May 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29782987/chitin-silk-fibroin-tio-2-bio-nanocomposite-as-a-biocompatible-wound-dressing-bandage-with-strong-antimicrobial-activity
#11
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Rasul Rakhshaei, Farzaneh Pakdel, Hosein Eslami, Vahid Fakhrzadeh, Mahdi Rahimi, Roya Salehi, Hossein Samadi Kafil
Interconnected microporous biodegradable and biocompatible chitin/silk fibroin/TiO2 nanocomposite wound dressing with high antibacterial, blood clotting and mechanical strength properties were synthesized using freeze-drying method. The prepared nanocomposite dressings were characterized using SEM, FTIR, and XRD analysis. The prepared nanocomposite dressings showed high porosity above 90% with well-defined interconnected porous construction. Swelling and water uptake of the dressing were 93%, which is great for wound dressing applications...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782985/facile-preparation-of-recombinant-spider-eggcase-silk-spheres-via-an-hfip-on-oil-approach
#12
Jianming Chen, Jinlian Hu, Peijun Zuo, Jingyu Shi, Mo Yang
Versatile spider silk proteins have been prepared by various methods in morphology of spheres for functional applications. Inspired from natural spinning process, a facile approach for the fabrication of silk spheres is described. Distinct from the traditional emulsification method, silk spheres were assembled as rapidly as 10 s by using the HFIP-on-Oil method without any surfactants and agitation used. Notably, a series of factors, such as evaporation rate of HFIP, polarity and molecular weight of oils play central roles on the final silk morphologies...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29781871/early-onset-of-diffuse-melanosis-cutis-under-pembrolizumab-therapy-illustrates-the-limitations-of-anti-pd-1-checkpoint-inhibitors
#13
Alexander Thiem, Patrick Schummer, Simon Ueberschaar, Andreas Kerstan, Hermann Kneitz, David Schrama, Silke Appenzeller, Svenja Meierjohann, Bastian Schilling, Matthias Goebeler, Anja Gesierich
Anti-PD-1 targeted immunotherapies have revolutionized the treatment of advanced melanoma and other tumor entities, and long disease-free intervals have been reported in responding patients. However, a considerable number of patients still progress rapidly after the start of anti-PD-1 antibodies. Here, we document two patients, 78 and 85-year old, who suffered from advanced BRAF-V600 wild-type melanoma and received pembrolizumab 2 mg/kg every 3 weeks as the first systemic treatment. After only one, respectively, two infusions of pembrolizumab, both patients developed melanuria and diffuse melanosis cutis (DMC) on sun-exposed areas of their skin...
May 17, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29781251/de-novo-design-of-recombinant-spider-silk-proteins-for-material-applications
#14
REVIEW
Ke Zheng, Shengjie Ling
Spider silks are well known for their superior mechanical properties that are stronger and tougher than steel despite being assembled at close to ambient conditions and using water as the solvent. However, it is a significant challenge to utilize spider silks for practical applications due to their limited sources. Fortunately, genetic engineering techniques offer a promising approach to produce useable amounts of spider silk variants. Starting from these recombinant spider silk proteins, a series of experiments and simulations strategies were developed to improve the recombinant spider silk proteins (RSSP) material design and fabrication with the aim of biomimicking the structure-property-function relationships of spider silks...
May 21, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29779947/intermittent-pili-mediated-forces-fluidize-neisseria-meningitidis-aggregates-promoting-vascular-colonization
#15
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
Neisseria meningitidis, a bacterium responsible for meningitis and septicemia, proliferates and eventually fills the lumen of blood capillaries with multicellular aggregates. The impact of this aggregation process and its specific properties are unknown. We first show that aggregative properties are necessary for efficient infection and study their underlying physical mechanisms. Micropipette aspiration and single-cell tracking unravel unique features of an atypical fluidized phase, with single-cell diffusion exceeding that of isolated cells...
May 15, 2018: Cell
https://www.readbyqxmd.com/read/29779013/treatment-of-sec62-over-expressing-tumors-by-thapsigargin-and-trifluoperazine
#16
Christina Körbel, Maximilian Linxweiler, Florian Bochen, Silke Wemmert, Bernhard Schick, Markus Meyer, Hans Maurer, Michael D Menger, Richard Zimmermann, Markus Greiner
Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. Therefore, we proposed the novel concept that e.g. lung-, prostate-, and thyroid-cancer patients should be tested for SEC62 over-expression, and developed a novel therapeutic strategy for a combinatorial treatment of SEC62 over-expressing tumors. The latter was based on the observations that treatment of SEC62 over-expressing tumor cells with SEC62-targeting siRNAs showed less resistance to Thapsigargin as well as a reduction in migratory potential and that the siRNA effects can be mimicked by the Calmodulin antagonist Trifluoperazine...
May 19, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29778323/is-there-a-flare-phenomenon-on-bone-scintigraphy-in-men-with-advanced-prostate-cancer-treated-with-radium-223
#17
Gesa Isensee, Anne Péporté, Joachim Müller, Sabine Schmid, Silke Gillessen, Aurelius Omlin
INTRODUCTION: Radium-223 is an approved survival-prolonging treatment option in men with castration-resistant prostate cancer (mCRPC) and bone metastases. In the registration trial (ALSYMPCA), no regular imaging was mandated. We aimed to analyze men with metastatic mCRPC treated with radium-223 who had bone scintigraphy for staging and treatment monitoring. PATIENTS AND METHODS: Retrospective chart review was performed of mCRPC patients who received 6 cycles of radium-223 and who underwent bone scintigraphy before start of radium-223 and after 3 and 6 cycles of treatment...
April 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29776993/tumor-immune-evasion-arises-through-loss-of-tnf-sensitivity
#18
Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro
Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a series of whole-genome clustered regularly interspaced short palindromic repeat (CRISPR)-based screens performed in vitro and in vivo to identify mechanisms of tumor immune evasion from cytotoxic lymphocytes [CD8+ T cells and natural killer (NK) cells]. Deletion of key genes within the tumor necrosis factor (TNF) signaling, interferon-γ (IFN-γ) signaling, and antigen presentation pathways provided protection of tumor cells from CD8+ T cell-mediated killing and blunted antitumor immune responses in vivo...
May 18, 2018: Science Immunology
https://www.readbyqxmd.com/read/29775504/biomimetic-supramolecular-fibers-exhibit-water-induced-supercontraction
#19
Yuchao Wu, Darshil U Shah, Baoyuan Wang, Ji Liu, Xiaohe Ren, Michael H Ramage, Oren A Scherman
Spider silk is a fascinating material, combining high strength and elasticity that outperforms most synthetic fibers. Another intriguing feature of spider silk is its ability to "supercontract," shrinking up to 50% when exposed to water. This is likely on account of the entropy-driven recoiling of secondary structured proteins when water penetrates the spider silk. In contrast, humidity-driven contraction in synthetic fibers is difficult to achieve. Here, inspired by the spider silk model, a supercontractile fiber (SCF), which contracts up to 50% of its original length at high humidity, comparable to spider silk, is reported...
May 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29774263/a-cross-cultural-analysis-of-posthumous-reproduction-the-significance-of-the-gender-and-margins-of-life-perspectives
#20
Yael Hashiloni-Dolev, Silke Schicktanz
The scholarly discussion of posthumous reproduction (PHR) focuses on informed consent and the welfare of the future child, for the most part overlooking cultural differences between societies. Based on a cross-cultural comparison of legal and regulatory documents, analysis of pivotal cases and study of scholarly and media discussions in Israel and Germany, this paper analyses the relevant ethical and policy issues, and questions how cultural differences shape the practice of PHR. The findings challenge the common classifications of PHR by highlighting the gender perspective and adding brain-dead pregnant women to the debate...
June 2017: Reproductive Biomedicine & Society Online
keyword
keyword
7652
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"