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https://www.readbyqxmd.com/read/28088609/leukemia-inhibitory-factor-impairs-structural-and-neurochemical-development-of-rat-visual-cortex-in-vivo
#1
Maren Engelhardt, Graziella di Cristo, Jochen Grabert, Silke Patz, Lamberto Maffei, Nicoletta Berardi, Petra Wahle
Minipump infusions into visual cortex in vivo at the onset of the critical period have revealed that the proinflammatory cytokine leukemia inhibitory factor (LIF) delays the maturation of thalamocortical projection neurons of the lateral geniculate nucleus, and tecto-thalamic projection neurons of the superior colliculus, and cortical layer IV spiny stellates and layer VI pyramidal neurons. Here, we report that P12-20 LIF infusion inhibits somatic maturation of pyramidal neurons and of all interneuron types in vivo...
January 11, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28088288/a-novel-mouse-model-of-staphylococcus-aureus-vascular-graft-infection-noninvasive-imaging-of-biofilm-development-in%C3%A2-vivo
#2
Hélène Van de Vyver, Philipp R Bovenkamp, Verena Hoerr, Katrin Schwegmann, Lorena Tuchscherr, Silke Niemann, Laura Kursawe, Christina Grosse, Annette Moter, Uwe Hansen, Ute Neugebauer, Michael T Kuhlmann, Georg Peters, Sven Hermann, Bettina Löffler
Staphylococcus aureus causes very serious infections of vascular grafts. Knowledge of the molecular mechanisms of this disease is largely lacking because of the absence of representable models. Therefore, the aim of this study was to set up a mouse model of vascular graft infections that closely mimics the human situation. A catheter was inserted into the right carotid artery of mice, which acted as a vascular graft. Mice were infected i.v. using 8 different S. aureus strains, and development of the infection was followed up...
January 4, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28088004/a-catechin-nanoformulation-inhibits-wm266-melanoma-cell-proliferation-migration-and-associated-neo-angiogenesis
#3
Nicoletta di Leo, Matteo Battaglini, Liron Berger, Martina Giannaccini, Luciana Dente, Silke Hampel, Orazio Vittorio, Giuseppe Cirillo, Vittoria Raffa
We validated the anticancer potential of a nanoformulation made by (+)-catechin, gelatin and carbon nanotubes in terms of inhibition of cancer cell proliferation, migration and associated neo-angiogenesis. Gelatin was selected to stabilize the catechin without compromising its anti-oxidant potential and the carbon nanotubes were used to increase its intracellular bioavailability. The anticancer potential of the resulting nanohybrid was validated on an aggressive melanoma cell line, in vitro and in zebrafish xenotransplants...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28087489/neurite-density-index-is-sensitive-to-age-related-differences-in-the-developing-brain
#4
Sila Genc, Charles B Malpas, Scott K Holland, Richard Beare, Timothy J Silk
PURPOSE: White matter development during childhood and adolescence is characterised by increasing white matter coherence and organisation. Commonly used scalar metrics, such as fractional anisotropy (FA), are sensitive to multiple mechanisms of white matter change and therefore unable to distinguish between mechanisms that change during development. We investigate the relationship between age and neurite density index (NDI) from neurite orientation dispersion and density imaging (NODDI), and the age-classification accuracy of NDI compared with FA, in a developmental cohort...
January 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28079070/biomaterials-silk-gland-mimic-spins-strong-fibres
#5
(no author information available yet)
No abstract text is available yet for this article.
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28077479/obstructive-sleep-apnoea-as-a-cause-of-nocturnal-nondipping-blood-pressure-recent-evidence-regarding-clinical-importance-and-underlying-mechanisms
#6
EDITORIAL
Sophie J Crinion, Silke Ryan, Walter T McNicholas
No abstract text is available yet for this article.
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28075434/diagnosis-and-surgical-correction-of-congenital-bilateral-patellar-luxation-in-two-dwarf-zebu-calves
#7
Göknil Kalayci, Cagri Binici, Julia Tünsmeyer, Silke Stein, Ahmad Al Aiyan, Kerstin Müller, Leo Brunnberg
This case study presents two female dwarf zebu calves with permanent bilateral flexion of the stifle joint secondary to bilateral congenital lateral patellar luxation. The patella could be manually repositioned bilaterally in the first calf (14 days old), but re-luxated immediately with release of manual pressure (luxation grade III). In the second calf (28 days old) both patellae were permanently luxated laterally (grade IV). The right and left stifles of each calf were operated in a staged procedure with approximately 14 days between surgery of the two sides...
January 11, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28073976/effects-of-carriers-emulsifiers-and-biopesticides-for-direct-silk-treatments-on-caterpillar-feeding-damage-and-ear-development-in-sweet-corn
#8
P J Westgate, B B Schultz, R V Hazzard
In the northeastern United States, control of Lepidopteran pests of sweet corn, particularly corn earworm [Helicoverpa zea (Boddie)], is difficult using organic methods. The direct application of corn oil and Bacillus thuringiensis (Bt) to corn silk has been shown to reduce ear damage from corn earworm in past studies; these studies sought to optimize this method by evaluating additional carrier and biopesticide mixtures that comply with the United States Federal Insecticide, Fungicide, and Rodenticide Act and National Organic Standards...
January 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28073813/association-between-the-healthy-eating-index-2010-and-nutrient-and-energy-densities-of-german-households-food-purchases
#9
Jonas Peltner, Silke Thiele
BACKGROUND: The USDA Healthy Eating Index (HEI) is used widely to measure diet quality because it allows a number of different applications. Although several evaluations of the HEI-2010 have already been carried out, there is lack of those which focus on associations between the HEI and nutrient intakes. This study updates and expands upon previous findings on these associations. METHODS: Using German consumption data, where ∼12 million purchases from 13 131 households are recorded, HEI-2010 total and individual scores, as well as several energy and nutrient densities were calculated...
January 9, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28073449/harmful-algal-bloom-forecast-system-for-sw-ireland-part-ii-are-operational-oceanographic-models-useful-in-a-hab-warning-system
#10
Caroline Cusack, Tomasz Dabrowski, Kieran Lyons, Alan Berry, Guy Westbrook, Rafael Salas, Conor Duffy, Glenn Nolan, Joe Silke
This study investigated the application of a three-dimensional physical hydrodynamic model in a harmful algal bloom forecast system for Bantry Bay, southwest Ireland. Modelled oceanographic conditions were studied and used to help understand observed changes in the chemical and biological patterns from the national biotoxins and phytoplankton monitoring program. The study focused on two toxic events in 2013. An upwelling event was predicted by the model prior to the appearance and population increase of potentially toxic diatoms, Pseudo-nitzschia, and associated domoic acid in shellfish...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073447/potential-impact-of-an-exceptional-bloom-of-karenia-mikimotoi-on-dissolved-oxygen-levels-in-waters-off-western-ireland
#11
Shane O'Boyle, Georgina McDermott, Joe Silke, Caroline Cusack
In the summer of 2005 an exceptional bloom of the dinoflagellate Karenia mikimotoi occurred along Ireland's Atlantic seaboard and was associated with the mass mortality of both benthic and pelagic marine life. Oxygen depletion, cellular toxicity and physical smothering, are considered to be the main factors involved in mortality. In this paper we use a theoretical approach based on stoichiometry (the Anderson ratio) and an average K. mikimotoi cellular carbon content of 329pgCcell(-1) (n=20) to calculate the carbonaceous and nitrogenous oxygen demand following bloom collapse...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073446/harmful-algal-bloom-forecast-system-for-sw-ireland-part-i-description-and-validation-of-an-operational-forecasting-model
#12
Tomasz Dabrowski, Kieran Lyons, Glenn Nolan, Alan Berry, Caroline Cusack, Joe Silke
A 3D primitive equation coastal ocean model for southwest Ireland, called the Bantry Bay model, was developed and implemented operationally. Validated model outputs have multiple uses. One of the incentives to develop the model was to explore the possible transport pathways that carry harmful algae blooms (HAB) into Bantry Bay. The model is nested offline in a regional North East Atlantic operational model. Surface forcing is taken from the half-degree Global Forecasting System, available at three-hourly intervals...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073441/applied-simulations-and-integrated-modelling-for-the-understanding-of-toxic-and-harmful-algal-blooms-asimuth-integrated-hab-forecast-systems-for-europe-s-atlantic-arc
#13
Julie Maguire, Caroline Cusack, Manuel Ruiz-Villarreal, Joe Silke, Deirdre McElligott, Keith Davidson
Reasons for the emergent interest in HABs are abundant, including concerns associated with human health, adverse effects on biological resources, economic losses attributed to recreation, tourism and seafood related industries, and the cost of maintaining public advisory services and monitoring programs for shellfish toxins and water quality. The impact of HABs can potentially be mitigated by early warning of their development. In this regard the project ASIMUTH (Applied Simulations and Integrated Modelling for the Understanding of Toxic and Harmful algal blooms) was borne in order to develop short term HAB alert systems for Atlantic Europe...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073436/forecasting-the-risk-of-harmful-algal-blooms
#14
EDITORIAL
Keith Davidson, Donald M Anderson, Marcos Mateus, Beatriz Reguera, Joe Silke, Marc Sourisseau, Julie Maguire
The "Applied Simulations and Integrated Modelling for the Understanding of Harmful Algal Blooms" (Asimuth) project sought to develop a harmful algal bloom (HAB) alert system for Atlantic Europe. This was approached by combining, at a national or regional level, regulatory monitoring phytoplankton and biotoxin data with satellite remote sensing and other information on current marine conditions, coupled with regional scale models that included a representation of HAB transport. Synthesis of these products was achieved by expert interpretation within HAB risk alert bulletins that were prepared on a regular basis (typically weekly) for use by the aquaculture industry...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28071695/development-of-a-multiple-hybrid-population-for-genome-wide-association-studies-theoretical-consideration-and-genetic-mapping-of-flowering-traits-in-maize
#15
Hui Wang, Cheng Xu, Xiaogang Liu, Zifeng Guo, Xiaojie Xu, Shanhong Wang, Chuanxiao Xie, Wen-Xue Li, Cheng Zou, Yunbi Xu
Various types of populations have been used in genetics, genomics and crop improvement, including bi- and multi-parental populations and natural ones. The latter has been widely used in genome-wide association study (GWAS). However, inbred-based GWAS cannot be used to reveal the mechanisms involved in hybrid performance. We developed a novel maize population, multiple-hybrid population (MHP), consisting of 724 hybrids produced using 28 temperate and 23 tropical inbreds. The hybrids can be divided into three subpopulations, two diallels and NC (North Carolina Design) II...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071193/screening-of-esbl-producing-enterobacteriacae-concomitant-with-low-degree-of-transmission-in-intensive-care-and-bone-marrow-transplant-units
#16
Giuseppe Valenza, Monika Schulze, Petra Friedrich, Wulf Schneider-Brachert, Thomas Holzmann, Silke Nickel, Verena Lehner-Reindl, Christiane Höller
BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are spreading worldwide in both hospital and community settings. In this study, the molecular epidemiology and the transmission modalities of ESBL-E in intensive care- and bone marrow transplant were investigated. METHODS: All patients included in this study were screened for presence of ESBL-E on admission and weekly. Relevant β-lactamase genes were identified by PCR and sequencing...
January 10, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28070066/molecular-structural-analysis-of-spider-s-capture-thread-and-viscid-droplets-studied-by-microscopic-ft-ir-spectroscopy
#17
Hironobu Yabe, Norihisa Katayama, Mitsuhiro Miyazawa
The molecular structural analysis of capture thread, including its viscid droplets of oriental golden orb-web spider Nephila clavata, has been performed by microscopic FT-IR spectroscopy. The obtained spectra of capture threads with and without viscid droplets indicate that the features in the region of 1400 - 1000 cm(-1) will be useful as marker bands for the degree of the dissolving of viscid droplet; further, the bands at 1395 and 1335 cm(-1) are attributable to the components of anchoring granules located at the inner side of viscid droplets...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28069914/survival-analysis-of-weekend-emergency-medical-admissions
#18
Richard Conway, Sean Cournane, Declan Byrne, Deirdre O'Riordan, Bernard Silke
BACKGROUND: We previously reported weekend emergency admissions to have a higher mortality; we have now examined the time profile of deaths, by weekday or weekend admission, in all emergency medical patients admitted between 2002 - 2014. METHODS: We divided admissions by a weekday or weekend (After 17.00 Friday-Sunday) hospital arrival. We examined survival following an admission using Cox proportional hazard models and Kaplan-Meier time to event analysis. RESULTS: 82,368 admissions were recorded in 44,628 patients...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28068904/long-term-kinetics-of-zika-virus-rna-and-antibodies-in-body-fluids-of-a-vasectomized-traveller-returning-from-martinique-a-case-report
#19
Guenter Froeschl, Kristina Huber, Frank von Sonnenburg, Hans-Dieter Nothdurft, Gisela Bretzel, Michael Hoelscher, Lothar Zoeller, Matthias Trottmann, Francisco Pan-Montojo, Gerhard Dobler, Silke Woelfel
BACKGROUND: The magnitude of the current Zika virus (ZIKV) epidemic has led to a declaration of a Public Health Emergency of International Concern by the WHO. Findings of viable viral particles in semen for several weeks are corroborating reports of sexual transmission of ZIKV. Serious consequences of a positive diagnostic result particularly in the pregnant patient are calling for precise diagnostic tools also at later time points after infection. Currently, recommendations suggest a diagnostic period of direct viral detection of 5 to 7 days after onset of symptoms in serum or plasma, and up to 3 weeks in urine samples...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28068357/role-of-bmdredd-during-apoptosis-of-silk-gland-in-silkworm-bombyx-mori
#20
Rui-Ting Chen, Peng Jiao, Zhen Liu, Yan Lu, Hu-Hu Xin, Deng-Pan Zhang, Yun-Gen Miao
Silk glands (SGs) undergo massive apoptosis driven degeneration during the larval-pupal transformation. To better understand this event on molecular level, we investigated the expression of apoptosis-related genes across the developmental transition period that spans day 4 in the fifth instar Bombyx mori larvae to day 2 pupae. Increases in the expression of BmDredd (an initiator caspase homolog) closely followed the highest BmEcR expression and resembled the expression trend of BmIcE. Simultaneously, we found that BmDredd expression was significantly higher in SG compared to other tissues at 18 h post-spinning, but reduced following injection of the apoptosis inhibitor (Z-DEVD-fmk)...
2017: PloS One
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