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https://www.readbyqxmd.com/read/28346631/when-breath-becomes-air
#1
Hugh Silk
No abstract text is available yet for this article.
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28345851/high-resolution-adhesion-mapping-of-the-odd-even-effect-on-a-layer-by-layer-coated-biomaterial-by-atomic-force-microscopy
#2
Kirstin Casdorff, Tobias Keplinger, Herve Bellanger, Benjamin Michen, Silke Sch N, Ingo Burgert
The adhesion behavior of polyelectrolyte multilayers consisting of poly-(diallyldimethylammonium chloride), PDDA, and poly(styrene sulfonate), PSS, towards a silicon AFM tip was studied during their build-up on wood, a chemically heterogeneous, micrometer rough biomaterial and compared with a nanometer rough substrate, namely quartz. The Atomic Force Microscopy based force mapping approach generated high resolution topography-, and adhesion maps within the first bilayers, which point toward a homogeneous layer-by-layer build-up on the biomaterial surface, and therefore indicate an even charge distribution...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28343220/hemorrhagic-transformations-after-thrombectomy-risk-factors-and-clinical-relevance
#3
Johannes Kaesmacher, Mirjam Kaesmacher, Christian Maegerlein, Claus Zimmer, Alexandra S Gersing, Silke Wunderlich, Benjamin Friedrich, Tobias Boeckh-Behrens, Justus F Kleine
BACKGROUND: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated clinical relevance of minor and major HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. METHODS: This is a retrospective single-center analysis of 409 patients with isolated MCA occlusion treated with ET. Patients' and procedural characteristics, severity of HT according to the European Cooperative Acute Stroke Study criteria, and clinical outcomes were analyzed...
March 25, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28342150/expression-and-characterization-of-human-%C3%AE-1-4-galactosyltransferase-1-%C3%AE-4galt1-using-silkworm-baculovirus-expression-system
#4
Daisuke Morokuma, Jian Xu, Masato Hino, Hiroaki Mon, Jasmeen S Merzaban, Masateru Takahashi, Takahiro Kusakabe, Jae Man Lee
Baculovirus expression vector system (BEVS) is widely known as a mass-production tool to produce functional recombinant glycoproteins except that it may not be always suitable for medical practice due to the differences in the structure of N-linked glycans between insects and mammalian. Currently, various approaches have been reported to alter N-linked glycan structures of glycoproteins derived from insects into terminally sialylated complex-type N-glycans. In the light of those studies, we also proposed in vitro maturation of N-glycan with mass-produced and purified glycosyltransferases by silkworm-BEVS...
March 24, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28341902/red-flags-for-maltese-adults-with-congenital-heart-disease-poorer-dental-care-and-less-sports-participation-compared-to-other-european-patients-an-approach-is-substudy
#5
Maryanne Caruana, Silke Apers, Adrienne H Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Maayke Sluman, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Alexandra Soufi, Edward Callus, Philip Moons, Victor Grech
Studies in recent years have explored lifestyle habits and health-risk behaviours in adult congenital heart disease (ACHD) patients when compared to controls. The aim of this study was to investigate differences in lifestyle habits between Maltese and other European ACHD patients. Data on alcohol consumption, cigarette smoking, substance misuse, dental care and physical activity collected in 2013-2015 during "Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease-International Study" (APPROACH-IS) were analysed...
March 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28341830/x-ray-dark-field-radiography-in-vivo-diagnosis-of-lung-cancer-in-mice
#6
Kai Scherer, Andre Yaroshenko, Deniz Ali Bölükbas, Lukas B Gromann, Katharina Hellbach, Felix G Meinel, Margarita Braunagel, Jens von Berg, Oliver Eickelberg, Maximilian F Reiser, Franz Pfeiffer, Silke Meiners, Julia Herzen
Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341613/radical-scavenging-activity-of-a-sunscreen-enriched-by-antioxidants-providing-protection-in-the-whole-solar-spectral-range
#7
Carla Souza, Patrícia Maia Campos, Sabine Schanzer, Stephanie Albrecht, Silke B Lohan, Juergen Lademann, Maxim E Darvin, Martina C Meinke
The literature claims that incorporation of antioxidants into sunscreens provides additional skin photoprotection by scavenging free radicals formed due to sun radiation, but there are limited in vivo studies that support this hypothesis. This study aims to examine whether addition of antioxidants to a broad-spectrum sunscreen increases its photoprotective effect in real-use conditions. Sunscreen formulations composed of stable UV filters (Tinosorb® S, Tinosorb® M, Uvinul® APlus, and Uvinul® T150) alone or in combination with antioxidants (Spirulina and dimethylmethoxy chromanol-loaded solid lipid nanoparticles) were developed and their appearance, odor, rheological behavior, Sun Protection Factor (SPF), and UVA protection were analyzed...
March 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28338795/-mom-i-don-t-want-to-hear-it-brain-response-to-maternal-praise-and-criticism-in-adolescents-with-major-depressive-disorder
#8
Jennifer S Silk, Kyung Hwa Lee, Rosalind D Elliott, Jill M Hooley, Ronald E Dahl, Anita Barber, Greg J Siegle
Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers' praise, criticism and neutral comments...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28337854/silk-fibroin-biomaterial-shows-safe-and-effective-wound-healing-in-animal-models-and-a-randomized-controlled-clinical-trial
#9
Wei Zhang, Longkun Chen, Jialin Chen, Lingshuang Wang, Xuexian Gui, Jisheng Ran, Guowei Xu, Hongshi Zhao, Mengfeng Zeng, Junfeng Ji, Li Qian, Jianda Zhou, Hongwei Ouyang, Xiaohui Zou
Due to its excellent biological and mechanical properties, silk fibroin has been intensively explored for tissue engineering and regenerative medicine applications. However, lack of translational evidence has hampered its clinical application for tissue repair. Here a silk fibroin film is developed and its translational potential is investigated for skin repair by performing comprehensive preclinical and clinical studies to fully evaluate its safety and effectiveness. The silk fibroin film fabricated using all green chemistry approaches demonstrates remarkable characteristics, including transmittance, fluid handling capacity, moisture vapor permeability, waterproofness, bacterial barrier properties, and biocompatibility...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28336960/co-expression-of-bira-with-biotin-bait-achieves-in-vivo-biotinylation-of-overexpressed-stable-n-glycosylated-srage-in-transgenic-silkworms
#10
Miyuki Kumano-Kuramochi, Ken-Ichiro Tatematsu, Mayumi Ohnishi-Kameyama, Mari Maeda-Yamamoto, Toshiro Kobori, Hideki Sezutsu, Sachiko Machida
Here, we demonstrated the expression of the N-glycosylated extracellular ligand binding domain of receptor for advanced glycation end products (sRAGE) in middle silk glands (MSGs) of transgenic silkworms using the GAL4/UAS system. Over 1 mg of sRAGE was obtained from one transgenic silkworm. sRAGE purified from the silkworm exhibited good stability and maintained specific ligand-binding ability. In addition, N-glycan analysis of sRAGE revealed that N-glucan completely lacked potentially allergenic fucose...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336603/high-quality-draft-genome-sequence-of-francisella-tularensis-subsp-holarctica-strain-08t0073-isolated-from-a-wild-european-hare
#11
Anne Busch, Prasad Thomas, Kerstin Myrtennäs, Mats Forsman, Silke Braune, Martin Runge, Herbert Tomaso
Here, we report a high-quality draft genome sequence of Francisella tularensis subsp. holarctica strain 08T0073, isolated from the cadaver of a wild European hare (Lepus europaeus) found near Helmstedt, Lower Saxony, Germany, in 2007. In Germany, infected hares are a major source of tularemia in humans.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28334613/role-of-mitochondrial-metabolism-in-the-control-of-early-lineage-progression-and-aging-phenotypes-in-adult-hippocampal-neurogenesis
#12
Ruth Beckervordersandforth, Birgit Ebert, Iris Schäffner, Jonathan Moss, Christian Fiebig, Jaehoon Shin, Darcie L Moore, Laboni Ghosh, Mariela F Trinchero, Carola Stockburger, Kristina Friedland, Kathrin Steib, Julia von Wittgenstein, Silke Keiner, Christoph Redecker, Sabine M Hölter, Wei Xiang, Wolfgang Wurst, Ravi Jagasia, Alejandro F Schinder, Guo-Li Ming, Nicolas Toni, Sebastian Jessberger, Hongjun Song, D Chichung Lie
No abstract text is available yet for this article.
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28334411/first-report-of-mating-disruption-with-an-aggregation-pheromone-a-case-study-with-tetropium-fuscum-coleoptera-cerambycidae
#13
Jon Sweeney, Peter J Silk, Marc Rhainds, Wayne MacKay, Cory Hughes, Kate Van Rooyen, Wayne MacKinnon, Gaetan Leclair, Steve Holmes, Edward G Kettela
Tetropium fuscum (F.), native to Europe and established in Nova Scotia, Canada, since at least 1990, is considered a low-to-moderate threat to spruce (Picea spp.) forests in North America and regulated as a quarantine pest by the Canadian Food Inspection Agency. We tested broadcast applications of the aggregation pheromone racemic (5E)-6,10-dimethyl-5,9-undecadien-2-ol (fuscumol), formulated at 10% concentration in Hercon Bio-Flakes (Hercon International, Emigsville, PA), for efficacy in disrupting T. fuscum mating and suppressing populations...
March 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28334365/effect-of-kit-and-pdgfra-mutations-on-survival-in-patients-with-gastrointestinal-stromal-tumors-treated-with-adjuvant-imatinib-an-exploratory-analysis-of-a-randomized-clinical-trial
#14
Heikki Joensuu, Eva Wardelmann, Harri Sihto, Mikael Eriksson, Kirsten Sundby Hall, Annette Reichardt, Jörg T Hartmann, Daniel Pink, Silke Cameron, Peter Hohenberger, Salah-Eddin Al-Batran, Marcus Schlemmer, Sebastian Bauer, Bengt Nilsson, Raija Kallio, Jouni Junnila, Aki Vehtari, Peter Reichardt
Importance: Little is known about whether the duration of adjuvant imatinib influences the prognostic significance of KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor α (PDGFRA) mutations. Objective: To investigate the effect of KIT and PDGFRA mutations on recurrence-free survival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated with surgery and adjuvant imatinib. Design, Setting, and Participants: This exploratory study is based on the Scandinavian Sarcoma Group VIII/Arbeitsgemeinschaft Internistische Onkologie (SSGXVIII/AIO) multicenter clinical trial...
March 23, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28333618/increasing-evidence-of-tick-borne-encephalitis-tbe-virus-transmission-the-netherlands-june-2016
#15
Adriaan Cg Weststrate, Daan Knapen, Gozewijn D Laverman, Bart Schot, Jan Jw Prick, Silke A Spit, Johan Reimerink, Barry Rockx, Felix Geeraedts
We present a case of endemic tick-borne encephalitis (TBE) occurring in June 2016 in the eastern part of the Netherlands in an area where a strain of TBE virus, genetically different from the common TBE virus strains in Europe, was reported in ticks in 2016. With the start of the tick season in spring, this second autochthonous Dutch TBE case should remind physicians to consider the possibility of endemic TBE in patients with respective symptoms.
March 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28333039/corrigendum-to-in-vivo-evaluation-of-copper-release-and-acute-local-tissue-reactions-after-implantation-of-copper-coated-titanium-implants-in-rats
#16
Andreas Hoene, Cornelia Prinz, Uwe Walschus, Silke Lucke, Maciej Patrzyk, Lutz Wilhelm, Hans-Georg Neumann, Michael Schlosser
In the "Materials and methods" chapter of the article given above, in section 2.1 titled "Implant samples and preparation" on page 2 (top paragraph of the right column), an incorrect value of 1 μg mm-2 for the average Cu load of the surface was inadvertently specified. This was due to an accidental mix-up of electronic data sets from examination of different implant series. The correct value is 0.2 μg mm-2. No other data given in the article are affected. The authors kindly apologize for this mistake.
March 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28332482/development-of-novel-silk-fibroin-polyvinyl-alcohol-sol-gel-bioactive-glass-composite-matrix-by-modified-layer-by-layer-electrospinning-method-for-bone-tissue-construct-generation
#17
B N Singh, K Pramanik
The worldwide occurrence of bone tissue related defects as well as diseases and lack of successful perpetual cure has attracted attention and accelerated exploration of composite scaffolding material with superior bioactivity, osteoinductivity and osteoconductivity properties. Among such biomaterials, silk fibroin and bioglass composite attained special emphasis to develop tissue engineered construct with a hierarchical structure ranging from nano to microscale thereby mimicking bone tissue extracellular matrix...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28332447/the-effect-of-native-silk-fibroin-powder-on-the-physical-properties-and-biocompatibility-of-biomedical-polyurethane-membrane
#18
Yan Zhuang, Qian Zhang, Jinqi Feng, Na Wang, Weilin Xu, Hongjun Yang
Naturally derived fibers such as silk fibroin can potentially enhance the biocompatibility of currently used biomaterials. This study investigated the physical properties of native silk fibroin powder and its effect on the biocompatibility of biomedical polyurethane. Native silk fibroin powder with an average diameter of 3 µm was prepared on a purpose-built machine. A simple method of phase inversion was used to produce biomedical polyurethane/native silk fibroin powder hybrid membranes at different blend ratios by immersing a biomedical polyurethane/native silk fibroin powder solution in deionized water at room temperature...
April 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28331969/which-factors-contribute-to-environmental-behaviour-of-landowners-in-southwestern-ontario-canada
#19
Silke Nebel, Jeff Brick, Van A Lantz, Ryan Trenholm
Loss of natural heritage is a problem that is particularly prevalent in areas of high population density. We used a survey to understand the factors that drive environmental behavior of landowners in southwestern Ontario, Canada. The survey, which contained questions about environmental attitude, pro-environmental behavior and demographics, was mailed to 18,090 rural route addresses, and we received 3256 completed surveys (18% response rate). Two types of environmental behavior, namely voluntarily increasing the area of land set aside for conservation, and enrollment in a conservation stewardship program, were significantly correlated with a positive attitude towards conservation...
March 22, 2017: Environmental Management
https://www.readbyqxmd.com/read/28331312/investigation-of-silk-fibroin-nanoparticle-decorated-poly-l-lactic-acid-composite-scaffolds-for-osteoblast-growth-and-differentiation
#20
Biao-Qi Chen, Ranjith Kumar Kankala, Ai-Zheng Chen, Ding-Zhu Yang, Xiao-Xia Cheng, Ni-Na Jiang, Kai Zhu, Shi-Bin Wang
Attempts to reflect the physiology of organs is quite an intricacy during the tissue engineering process. An ideal scaffold and its surface topography can address and manipulate the cell behavior during the regeneration of targeted tissue, affecting the cell growth and differentiation significantly. Herein, silk fibroin (SF) nanoparticles were incorporated into poly(l-lactic acid) (PLLA) to prepare composite scaffolds via phase-inversion technique using supercritical carbon dioxide (SC-CO2). The SF nanoparticle core increased the surface roughness and hydrophilicity of the PLLA scaffolds, leading to a high affinity for albumin attachment...
2017: International Journal of Nanomedicine
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