keyword
MENU ▼
Read by QxMD icon Read
search

Silk

keyword
https://www.readbyqxmd.com/read/28723752/full-covered-self-expandable-metal-stents-for-the-treatment-of-anastomotic-leak-using-a-silk-thread
#1
Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Sun Hwi Hwang, Si Hak Lee
To evaluate the safety and effectiveness of fixation of the fully covered self-expandable metal stent (SEMS) placement using a silk thread for complete closure of an anastomotic leak. An anastomotic leak is a life-threatening complication after gastrectomy. Although the traditional treatment of choice was surgical re-intervention, an endoscopic SEMS can be used alternatively.During the study period, we retrospectively reviewed consecutive patients who received a modified covered SEMS capable of being fixed using a silk thread (Shim technique) due to an anastomotic leak after gastrectomy to prevent stent migration...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723569/xiap-loss-triggers-ripk3-and-caspase-8-driven-il-1%C3%AE-activation-and-cell-death-as-a-consequence-of-tlr-myd88-induced-ciap1-traf2-degradation
#2
Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP suppresses these events remains unclear. Here, we show that TLR-MyD88 causes the proteasomal degradation of the related IAP, cIAP1, and its adaptor, TRAF2, by inducing TNF and TNF Receptor 2 (TNFR2) signaling. Genetically, we define that myeloid-specific cIAP1 loss promotes TLR-induced RIPK3-caspase-8 and IL-1β activity in the absence of XIAP...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28723387/sigma-1-receptor-activation-modifies-intracellular-calcium-exchange-in-the-g93a-hsod1-als-model
#3
Vedrana Tadić, Ayse Malci, Nadine Goldhammer, Beatrice Stubendorff, Saikata Sengupta, Tino Prell, Silke Keiner, Jingyu Liu, Madlen Guenther, Christiane Frahm, Otto W Witte, Julian Grosskreutz
Aberrations in intracellular calcium (Ca(2+)) have been well established within amyotrophic lateral sclerosis (ALS), a severe motor neuron disease. Intracellular Ca(2+) concentration is controlled in part through the endoplasmic reticulum (ER) mitochondria Ca(2+) cycle (ERMCC). The ER supplies Ca(2+) to the mitochondria at close contacts between the two organelles, i.e. the mitochondria-associated ER membranes (MAMs). The Sigma 1 receptor (Sig1R) is enriched at MAMs, where it acts as an inter-organelle signalling modulator...
July 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28723195/lanthanide-labeled-immunochromatographic-strip-assay-for-the-on-site-identification-of-ancient-silk
#4
Qiushi You, Miaomiao Liu, Yang Liu, Hailing Zheng, Zhiwen Hu, Yang Zhou, Bing Wang
The on-site identification of ancient silks has long been a key challenge in archeology. Therefore, a rapid, cost-effective, sensitive analytical approach is highly desirable. In this paper, a lanthanide-labeled immunochromatographic strip which is suitable for the on-site identification of ancient silks is described. Compared with the conventional colloidal gold-based immunochromatographic strip, this strip shows much higher analytical sensitivity and better quantitative discrimination. The limit of detection (LOD) of the strip for silk fibroin (SF) was calculated as 8...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723068/biomimetic-hybridization-of-kevlar-into-silk-fibroin-nanofibrous-strategy-for-improved-mechanic-properties-of-flexible-composites-and-filtration-membranes
#5
Lili Lv, Xiangsheng Han, Lu Zong, Mingjie Li, Jun You, Xiaochen Wu, Chaoxu Li
Silk, one of the strongest natural biopolymers, was hybridized with Kevlar, one of the strongest synthetic polymers, through a biomimetic nanofibrous strategy. Regenerated silk materials have outstanding properties in transparency, biocompatibility, biodegradability and sustainability, and promised the applications as diverse as in pharmaceutics, electronics, photonic devices and membranes. To compete with super mechanic properties of their natural counterpart, regenerated silk materials have been hybridized with inorganic fillers such as graphene and carbon nanotubes, but frequently losing essential mechanic flexibility...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28722016/silk-micrococoons-for-protein-stabilisation-and-molecular-encapsulation
#6
Ulyana Shimanovich, Francesco S Ruggeri, Erwin De Genst, Jozef Adamcik, Teresa P Barros, David Porter, Thomas Müller, Raffaele Mezzenga, Christopher M Dobson, Fritz Vollrath, Chris Holland, Tuomas P J Knowles
Naturally spun silks generate fibres with unique properties, including strength, elasticity and biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk, obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules with controllable geometry and variable levels of intermolecular β-sheet content in their protein shells. We demonstrate that such micrococoons can store internally the otherwise highly unstable liquid native silk for several months and without apparent effect on its functionality...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28721663/influence-of-direct-or-indirect-contact-for-the-cytotoxicity-and-blood-compatibility-of-spider-silk
#7
J W Kuhbier, V Coger, J Mueller, C Liebsch, F Schlottmann, V Bucan, P M Vogt, S Strauss
Spider silk became one of the most-researched biomaterials in the last years due to its unique mechanical strength and most favourable chemical composition for tissue engineering purposes. However, standardized analysis of cytocompatibility is missing. Therefore, the aim of this study was to investigate hemolysis, cytotoxicity of native spider silk as well as influences on the cell culture medium. Changes of cell culture medium composition, osmolarity as well as glucose and lactate content were determined via ELISA measurement...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28721519/variations-of-cocoon-external-lipids-during-wolf-spiderlings-development
#8
F Ruhland, S Schulz, Marie Trabalon
This study presents the first characterisation of the silk lipids of the cocoons of a wolf spider (Pardosa saltans). Wolf spiders' maternal behaviour is complex and involves guarding a cocoon for several weeks, and so cocoons must emit cues to ensure their care and the development of juveniles. We investigated cues associated with the cocoon silk. We assessed qualitative changes of the lipid contents and the composition of cocoon silk in relation to the development of P. saltans wolf spider juveniles. Gas chromatography-mass spectrometry of P...
July 18, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28720421/assessment-of-the-hiv-1-reservoir-in-cd4-regulatory-t-cells-by-a-droplet-digital-pcr-based-approach
#9
Gábor Artúr Dunay, Anastasia Solomatina, Silke Kummer, Anja Hüfner, Julia Katharina Bialek, Johanna Maria Eberhard, Eva Tolosa, Joachim Hauber, Julian Schulze Zur Wiesch
The relative contribution of regulatory T cells (Treg) as reservoir of HIV-1 in patients on chronic antiretroviral therapy is unclear to date. The aim of the current study was to assess the total HIV DNA burden and replication competent viral reservoir in Treg in comparison to central and effector memory cells (Tcm and Tem). Peripheral blood mononuclear cells were obtained from 10 HIV patients treated with antiretroviral therapy and one HIV elite controller. Droplet Digital PCR (ddPCR) was used to quantify total HIV DNA loads in FACS sorted CD4+ Treg (CD25+CD127lo) as compared with Tcm (CD45RO+CCR7+) and Tem (CD45RO+CCR7-)...
July 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28718615/development-of-nanofiber-sponges-containing-nerve-guidance-conduit-for-peripheral-nerve-regeneration-in-vivo
#10
Binbin Sun, Zi-Fei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo, Yinxian Yu
In the study of hollow nerve guidance conduit (NGC), the dispersion of regenerated axons always confused the researchers. To address this problem, filler-containing NGC was prepared, which showed better effect in the application of nerve tissue engineering. In this study, nanofiber sponges with abundant macro-pores, high porosity, and superior compressive strength were fabricated by electrospinning and freeze-drying. Poly (l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) nanofiber sponges were used as filler to prepare three-dimensional nanofiber sponges-containing (NS-containing) NGC...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718444/tumor-host-cell-interactions-in-ovarian-cancer-pathways-to-therapy-failure
#11
REVIEW
Elke Pogge von Strandmann, Silke Reinartz, Uwe Wager, Rolf Müller
Although most ovarian cancer patients are highly responsive to chemotherapy, they frequently present with recurrent metastatic lesions that result in poor overall survival, a situation that has not changed in the last 20 years. This review discusses new insights into the regulation of ovarian cancer chemoresistance with a focus on the emerging role of immune and other host cells. Here, we summarize the complex molecular pathways that regulate the interaction between tumor and host cells, discuss the limitations of current in vitro and in vivo models for translational studies, and present perspectives for the development of innovative therapies...
February 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28718104/nicht-auf-raas-blocker-verzichten
#12
Silke Wedekind
No abstract text is available yet for this article.
July 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28716122/systematic-evaluation-of-oligodeoxynucleotide-binding-and-hybridization-to-modified-multi-walled-carbon-nanotubes
#13
Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann
BACKGROUND: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to the urothelium and then into cancer cells might be achieved by the local application of multi-walled carbon nanotubes (MWCNT). In the present study, pristine MWCNT and MWCNT functionalized with hydrophilic moieties were synthesized and then investigated regarding their physicochemical characteristics, dispersibility, biocompatibility, cellular uptake and mucoadhesive properties...
July 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28715214/exploiting-carbonyl-groups-to-control-intermolecular-rhodium-catalyzed-alkene-and-alkyne-hydroacylation
#14
Thomas J Coxon, Maitane Fernández, James Barwick-Silk, Alasdair I McKay, Louisa E Britton, Andrew S Weller, Michael C Willis
Readily available β-carbonyl-substituted aldehydes are shown to be exceptional substrates for Rh-catalyzed intermolecular alkene and alkyne hydroacylation reactions. By using cationic rhodium catalysts incorporating bisphosphine ligands, efficient and selective reactions are achieved for β-amido, β-ester, and β-keto aldehyde substrates, providing a range of synthetically useful 1,3-dicarbonyl products in excellent yields. A correspondingly broad selection of alkenes and alkynes can be employed. For alkyne substrates, the use of a catalyst incorporating the Ampaphos ligand triggers a regioselectivity switch, allowing both linear and branched isomers to be prepared with high selectivity in an efficient manner...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28715169/fabrication-of-biocompatible-functional-and-transparent-hybrid-films-based-on-silk-fibroin-and-epoxy-silane-for-biophotonics
#15
Robson Rosa da Silva, Mauricio Cavicchioli, Lais Rocalho de Lima, Caio Gomide Otoni, Hernane da Silva Barud, Silvia Helena Santagneli, Agnieszka Tercjak, André Capaldo Amaral, Renata Aquino Carvalho, Sidney José Lima Ribeiro
In this work we explored the fabrication of flexible and transparent hybrids of silk fibroin and epoxy modified siloxane for photonic applications. It is well known that regenerated silk fibroin (SF) solutions can form free-standing films with high transparency. Although SF has a restricted number of chemically reactive side groups, the main issues of as-casted pristine SF films regard the high solubility into aqueous media, brittleness, and low thermal stability. The design of SF films with enhanced functionality but yet highly transparent triggers new opportunities on broader range of applications in biophotonics...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714141/intrinsic-3d-prestressing-a-new-route-for-increasing-strength-and-improving-toughness-of-hybrid-inorganic-biocements
#16
Martha Schamel, Jake E Barralet, Michael Gelinsky, Jürgen Groll, Uwe Gbureck
Cement is the most consumed resource and is the most widely used material globally. The ability to extrinsically prestress cementitious materials with tendons usually made from steel allows the creation of high-strength bridges and floors from this otherwise brittle material. Here, a dual setting cement system based on the combination of hydraulic cement powder with an aqueous silk fibroin solution that intrinsically generates a 3D prestressing during setting, dramatically toughening the cement to the point it can be cut with scissors, is reported...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28711420/-left-heart-catheterization-followed-by-other-invasive-procedures-regional-comparisons-reveal-peculiar-differences
#17
Silke Piedmont, Enno Swart, Rosie Kenmogne, Rüdiger C Braun-Dullaeus, Bernt-Peter Robra
BACKGROUND AND AIMS: Diagnostic left heart catheterization (LHC) is recommended if the therapeutic consequences of a bypass operation or percutaneous coronary intervention (PCI) are being considered. The present study examines regional differences in healthcare provision and therapeutic consequences of LHC, differentiated by counties and hospitals of the German federal state of Saxony-Anhalt. In addition, it looks at which patient-related factors influence the proportion of follow-up interventions...
July 12, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28710484/colored-and-fluorescent-nanofibrous-silk-as-a-physically-transient-chemosensor-and-vitamin-deliverer
#18
Kyungtaek Min, Sookyoung Kim, Chang Gun Kim, Sunghwan Kim
Biodegradable and physically transient optics represent an emerging paradigm in healthcare devices by harnessing optically active system and obviating issues with chronic uses. Light emitting components that can efficiently interact with their environments have advantages of high sensitivity, visibility, and wireless operation. Here, we report a novel combination of silk biopolymer and optically active organic dyes resulting in versatile fluorescent silk nanofibers (FSNs). FSNs generated by the electrospinning method exhibit attractive functions of the doped organic dyes along with programming the system that physically disappear at prescribed time...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710361/the-dental-phenotype-of-hairless-dogs-with-foxi3-haploinsufficiency
#19
Kornelius Kupczik, Alexander Cagan, Silke Brauer, Martin S Fischer
Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709421/health-related-quality-of-life-in-patients-with-idiopathic-pulmonary-fibrosis-in-clinical-practice-insights-ipf-registry
#20
Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Felix J F Herth, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Matthias Held, Thomas Bahmer, Marion Frankenberger, Jürgen Behr
BACKGROUND: The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations of various QoL instruments between each other and with patient characteristics at baseline. METHODS: Six hundred twenty-three IPF patients with available QoL data (St George's Respiratory Questionnaire SGRQ, UCSD Shortness-of-Breath Questionnaire SoB, EuroQol visual analogue scale and index EQ-5D, Well-being Index WHO-5) were analysed...
July 14, 2017: Respiratory Research
keyword
keyword
7652
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"