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https://www.readbyqxmd.com/read/29143442/development-of-biomimetic-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-via-a-novel-electrospinning-approach
#1
Emily Yu, Hao-Yang Mi, Jue Zhang, James A Thomson, Lih-Sheng Turng
A new electrospinning approach for fabricating vascular grafts with a layered, circumferentially aligned, and micro-wavy fibrous structure similar to natural elastic tissues has been developed. The customized electrospinning collector was able to generate wavy fibers using the dynamic "jump rope" collecting process, which also solved the sample removal problem for mandrel-type collectors. In this study, natural silk fibroin and synthetic thermoplastic polyurethane (TPU) were combined at different weight ratios to produce hybrid small-diameter vascular grafts...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29143196/effect-of-low-dose-aspirin-on-chronic-acid-reflux-esophagitis-in-rats
#2
Takahiro Masuda, Fumiaki Yano, Nobuo Omura, Kazuto Tsuboi, Masato Hoshino, Se Ryung Yamamoto, Shunsuke Akimoto, Hideyuki Kashiwagi, Katsuhiko Yanaga
BACKGROUND: Clinical role of low-dose aspirin (LDA) in pathogenesis of gastroesophageal reflux disease is by far controversial. This can be attributed to the paucity of basic research detailing the mechanism of LDA-induced esophageal mucosal injury (EI) on underlying chronic acid reflux esophagitis (RE). AIM: The aim of this study was to clarify the effect of LDA on chronic RE in rats. METHODS: Esophagitis was induced in 8-week-old male Wistar rats by ligating the border between forestomach and glandular portion with a 2-0 silk tie and covering the duodenum with a small piece of 18-Fr Nélaton catheter...
November 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29142853/silk-suture-reaction-in-thyroid-surgery
#3
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Silk suture reaction (i.e., a benign granulomatous inflammatory foreign body reaction) is a rare complication of thyroid surgery. Here, two cases of post-thyroidectomy suture reaction are presented. Both of the patients were female, one is 48 and the other is 34 years old. The patients were presented with neck swelling and leakage of serous fluid from the Kocher's incision. Both patients had normal free T4, free T3, and TSH values. The 48-year-old female patient had a right subtotal and left near-total thyroidectomy 6 years ago and the other had bilateral total thyroidectomy 6 years ago...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142267/in-vivo-characterization-of-the-electrophysiological-and-astrocytic-responses-to-a-silicon-neuroprobe-implanted-in-the-mouse-neocortex
#4
Katrien Mols, Silke Musa, Bart Nuttin, Liesbet Lagae, Vincent Bonin
Silicon neuroprobes hold great potential for studies of large-scale neural activity and brain computer interfaces, but data on brain response in chronic implants is limited. Here we explored with in vivo cellular imaging the response to multisite silicon probes for neural recordings. We tested a chronic implant for mice consisting of a CMOS-compatible silicon probe rigidly implanted in the cortex under a cranial imaging window. Multiunit recordings of cortical neurons with the implant showed no degradation of electrophysiological signals weeks after implantation (mean spike and noise amplitudes of 186 ± 42 µVpp and 16 ± 3...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142078/candida-auris-a-review-of-the-literature
#5
REVIEW
Anna Jeffery-Smith, Surabhi K Taori, Silke Schelenz, Katie Jeffery, Elizabeth M Johnson, Andrew Borman, Rohini Manuel, Colin S Brown
The emerging pathogen Candida auris has been associated with nosocomial outbreaks on five continents. Genetic analysis indicates the simultaneous emergence of separate clades of this organism in different geographical locations. Invasive infection and colonization have been detected predominantly in patients in high-dependency settings and have garnered attention due to variable antifungal resistance profiles and transmission within units instituting a range of infection prevention and control measures. Issues with the identification of C...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29141914/proteotranscriptomics-reveal-signaling-networks-in-the-ovarian-cancer-microenvironment
#6
Thomas Worzfeld, Florian Finkernagel, Silke Reinartz, Anne Konzer, Till Adhikary, Andrea Nist, Thorsten Stiewe, Uwe Wagner, Mario Looso, Johannes Graumann, Rolf Müller
Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages (TAM) create a unique microenvironment promoting cancer progression, chemoresistance and immuno-suppression. However, the underlying signaling mechanisms remain largely obscure.  To chart these signaling networks, we performed comprehensive proteomic and transcriptomic analyses of TU, TAT and TAM from ascites of ovarian cancer patients...
November 15, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29141006/the-mitochondrial-genome-of-muga-silkworm-antheraea-assamensis-and-its-comparative-analysis-with-other-lepidopteran-insects
#7
Deepika Singh, Debajyoti Kabiraj, Pragya Sharma, Hasnahana Chetia, Ponnala Vimal Mosahari, Kartik Neog, Utpal Bora
Muga (Antheraea assamensis) is an economically important silkmoth endemic to the states of Assam and Meghalaya in India and is the producer of the strongest known commercial silk. However, there is a scarcity of genomic and proteomic data for understanding the organism at a molecular level. Our present study is on decoding the complete mitochondrial genome (mitogenome) of A. assamensis using next generation sequencing technology and comparing it with other available lepidopteran mitogenomes. Mitogenome of A...
2017: PloS One
https://www.readbyqxmd.com/read/29140181/rational-design-of-a-high-strength-bone-scaffold-platform-based-on-in-situ-hybridization-of-bacterial-cellulose-nano-hydroxyapatite-framework-and-silk-fibroin-reinforcing-phase
#8
Pei Jiang, Jiabing Ran, Pan Yan, Lingyue Zheng, Xinyu Shen, Hua Tong
Bacterial cellulose/hydroxyapatite (BC/HAp) composite had favourable bioaffinity but its poor mechanical strength limited its widespread applications in bone tissue engineering (BTE). Silk fibroin, which possesses special crystalline structure, has been widely used as organic reinforcing material, and different SFs have different amino acid sequences, which exhibit different bioaffinity and mechanical properties. In this regard, bacterial cellulose-Antheraea yamamai silk fibroin/hydroxyapatite(BC-AYSF/HAp), bacterial cellulose-Bombyx mori silk fibroin/hydroxyapatite(BC-BMSF/HAp), and BC/HAp nano-composites were synthesized via a novel in situ hybridization method...
November 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29138940/silk-fibroin-pellethane%C3%A2-cardiovascular-patches-effect-of-silk-fibroin-concentration-on-vascular-remodeling-in-rat-model
#9
Pinkarn Chantawong, Takashi Tanaka, Akiko Uemura, Kazumi Shimada, Akira Higuchi, Hirokazu Tajiri, Kohta Sakura, Tomoaki Murakami, Yasumoto Nakazawa, Ryou Tanaka
Life-threatening cardiovascular anomalies require surgery for structural repair with cardiovascular patches. The biomaterial patch, derived from Bombyx mori silk fibroin (SF), is used as an alternative material due to its excellent tissue affinity and biocompatibility. However, SF lacks the elastomeric characteristics required for a cardiovascular patch. In order to overcome this shortcoming, we combined the thermoplastic polyurethane, Pellethane® (PU) with SF to develop an elastic biocompatible patch. Therefore, the purpose of this study was to investigate the feasibility of the blended SF/PU patch in a vascular model...
November 14, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29138566/studies-on-the-use-of-recombinant-spider-silk-protein-polyvinyl-alcohol-electrospinning-membrane-as-wound-dressing
#10
Liang Zhao, Denglong Chen, Qinghua Yao, Min Li
A series of wound membranes of polyvinyl alcohol and recombinant spider silk protein (pNSR16) was prepared by electrospinning. The membrane was analyzed by scanning electron microscopy, atomic force microscopy, and Fourier transform infrared spectroscopy. The result showed that the three factors that affected average fiber diameter from high to low were, voltage, flow speed, and solidification distance; and the three factors that affected fiber uniformity from high to low were, flow speed, solidification distance, and voltage...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29138464/bone-regeneration-is-associated-with-the-concentration-of-tumour-necrosis-factor-%C3%AE-induced-by-sericin-released-from-a-silk-mat
#11
You-Young Jo, HaeYong Kweon, Dae-Won Kim, Kyunghwa Baek, Min-Keun Kim, Seong-Gon Kim, Weon-Sik Chae, Je-Yong Choi, Horatiu Rotaru
To understand the osteogenic effect of the middle layer of the silk cocoon, sericin was examined for its cellular effects associated with tumor necrosis factor-α (TNF-α) signaling in this study. The fragmented sericin proteins in the silk mat were evaluated for the TNF-α expression level in murine macrophages. The concentration of protein released from silk mats was higher in the outermost and the innermost layers than in the middle layers, and the protein released from the silk mat was identified as sericin...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132420/substance-p-and-patterned-silk-biomaterial-stimulate-periodontal-ligament-stem-cells-to-form-corneal-stroma-in-a-bioengineered-three-dimensional-model
#12
Jialin Chen, Wei Zhang, Peyman Kelk, Ludvig J Backman, Patrik Danielson
BACKGROUND: We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane. METHODS: Human PDLSCs were isolated and identified. The neuropeptide substance P (SP) was added in keratocyte differentiation medium (KDM) to evaluate its effect on keratocyte differentiation of PDLSCs. PDLSCs were then seeded on patterned silk membrane and cultured with KDM and SP...
November 13, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29132177/an-insight-on-silk-protein-sericin-from-processing-to-biomedical-application
#13
Farogh Ahsan, Tarique Mahmood Ansari, Shazia Usmani, Paramdeep Bagga
Silks are naturally occurring polymers that have been used clinically as sutures for hundreds of years. It's so for obtained from insects or worms, silk consists of a filament core protein, termed fibroin, and a glue-like coating made up of sericin proteins. An important component of silk has an extended history of being discarded as a waste in the course of silk processing. The cost of sericin for tissue engineering is underestimated and its capability in using as regenerative remedy has simply began to be explored...
November 13, 2017: Drug Research
https://www.readbyqxmd.com/read/29132106/silver-oxide-nanoparticles-embedded-silk-fibroin-spuns-microwave-mediated-preparation-characterization-and-their-synergistic-wound-healing-and-anti-bacterial-activity
#14
Punuri Jayasekhar Babu, Mukesh Doble, Ashok M Raichur
The synergistic wound healing and antibacterial activity of silver oxide nanoparticles embedded silk fibroin (Ag2O-SF) spuns is reported here. UV-Vis spectro photometric analysis of these spuns showed the surface plasmon resonance (SPR) confirming the formation of the silver oxide nanoparticles (Ag2O NPs) on the surface of the silk fibroin (SF). Scanning electron microscope (SEM) and Differential scanning calorimetry (DSC) also confirmed the presence of Ag2O NPs on surface of SF. X-ray diffraction (XRD) analysis revealed the crystalline nature of both SF and Ag2O-SF...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29131636/template-guided-assembly-of-silk-fibroin-on-cellulose-nanofibers-for-robust-nanostructures-with-ultrafast-water-transport
#15
Rui Xiong, Ho Shin Kim, Shuaidi Zhang, Sunghan Kim, Volodymyr F Korolovych, Ruilong Ma, Yaroslava G Yingling, Canhui Lu, Vladimir V Tsukruk
The construction of multi-length scaled hierarchical nanostructures from diverse natural components is critical in the progress towards all-natural nanocomposites with structural robustness and versatile added functionalities. Here, we report a spontaneous formation of peculiar shish kebab nanostructures via the periodic self-assembly of silk fibroin along straight segments of cellulose nanofibers. We suggest that the formation of these "shish-kebab" nanostructures is facilitated by the preferential organization of heterogeneous silk domains along the crystalline cellulose nanofiber driven by modulated axial distribution of crystalline planes, hydrogen bonding and hydrophobic interactions as supported by all-atom molecular dynamic simulations...
November 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29131010/blockade-of-experimental-multiple-sclerosis-by-inhibition-of-the-acid-sphingomyelinase-ceramide-system
#16
Katrin Anne Becker, Ramona Halmer, Laura Davies, Brian D Henry, Regan Ziobro-Henry, Yann Decker, Yang Liu, Erich Gulbins, Klaus Fassbender, Silke Walter
BACKGROUND: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are not fully understood. METHODS: We tested the role of the acid sphingomyelinase/ceramide system in a model of MS, i.e. experimental autoimmune encephalomyelitis (EAE). Mice were immunized with myelin-oligodendrocyte glycoprotein and the development of the disease was analyzed by histology, immunological tests and clinical assessment in wildtype and acid sphingomyelinase (Asm)-deficient mice...
November 6, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29130951/prehospital-computed-tomography-angiography-in-acute-stroke-management
#17
Michael Kettner, Stefan Alexander Helwig, Andreas Ragoschke-Schumm, Lenka Schwindling, Safwan Roumia, Isabel Keller, Daniel Martens, Johann Kulikovski, Matthias Manitz, Martin Lesmeister, Silke Walter, Iris Quasar Grunwald, Thomas Schlechtriemen, Wolfgang Reith, Klaus Fassbender
BACKGROUND: An ambulance equipped with a computed tomography (CT) scanner, a point-of-care laboratory, and telemedicine capabilities (mobile stroke unit [MSU]) has been shown to enable the delivery of thrombolysis to stroke patients directly at the emergency site, thereby significantly decreasing time to treatment. However, work-up in an MSU that includes CT angiography (CTA) may also potentially facilitate triage of patients directly to the appropriate target hospital and specialized treatment, according to their individual vascular pathology...
October 31, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29129733/doxorubicin-synergism-and-resistance-reversal-in-human-neuroblastoma-be-2-c-cell-lines-an-in-vitro-study-with-dextran-catechin-nanohybrids
#18
Orazio Vittorio, Marion Le Grand, Sami A Makharza, Manuela Curcio, Paola Tucci, Francesca Iemma, Fiore Pasquale Nicoletta, Silke Hampel, Giuseppe Cirillo
Hybrid nanocarrier consisting in nanographene oxide coated by a dextran-catechin conjugate was proposed in the efforts to find more efficient Neuroblastoma treatment with Doxorubicin chemotherapy. The dextran-catechin conjugate was prepared by immobilized laccase catalysis and its peculiar reducing ability exploited for the synthesis of the hybrid carrier. Raman spectra and DSC thermograms were recorded to check the physicochemical properties of the nanohybrid, while DLS measurements, SEM, TEM, and AFM microscopy allowed the determination of its morphological and dimensional features...
November 9, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29129255/regional-variation-in-quality-of-life-in-patients-with-a-fontan-circulation-a-multinational-perspective
#19
Nicholas D Fogleman, Silke Apers, Philip Moons, Stacey Morrison, Samuel G Wittekind, Martha Tomlin, Kathy Gosney, Maayke A Sluman, Bengt Johansson, Junko Enomoto, Mikael Dellborg, Chun-Wei Lu, Raghavan Subramanyan, Koen Luyckx, Werner Budts, Jamie Jackson, Adrienne Kovacs, Alexandra Soufi, Katrine Eriksen, Corina Thomet, Malin Berghammer, Edward Callus, Susan M Fernandes, Maryanne Caruana, Stephen C Cook, Andrew S Mackie, Kamila S White, Paul Khairy, Shelby Kutty, Gruschen Veldtman
BACKGROUND: Impaired quality of life (QOL) is associated with congenital heart disease (CHD) and country of residence; however, few studies have compared QOL in patients with differing complexities of CHD across regional populations. The current study examined regional variation in QOL outcomes in a large multinational sample of patients with a Fontan relative to patients with atrial septal defects (ASDs) and ventricular septal defects (VSDs). METHODS: From the Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease-International Study (APPROACH-IS), 405 patients (163 Fontan and 242 ASD/VSD) across Asia, Europe, and North America provided consent for access to their medical records and completed a survey evaluating QOL (0 to 100 linear analog scale)...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29129025/assessment-of-circulating-wnt1-inducible-signalling-pathway-protein-1-wisp-1-ccn4-as-a-novel-biomarker-of-obesity
#20
Christopher Tacke, Krasimira Aleksandrova, Miriam Rehfeldt, Veronica Murahovschi, Mariya Markova, Margrit Kemper, Silke Hornemann, Ulrike Kaiser, Caroline Honig, Christiana Gerbracht, Stefan Kabisch, Tina Hörbelt, D Margriet Ouwens, Martin O Weickert, Heiner Boeing, Andreas F H Pfeiffer, Olga Pivovarova, Natalia Rudovich
WNT1 inducible signaling pathway protein 1 (WISP-1/CCN4) is a novel adipokine, which is upregulated in obesity, and induces a pro-inflammatory response in macrophages in-vitro. Preclinical observations suggested WISP-1/CCN4 as a potential candidate for novel obesity therapy targeting adipose tissue inflammation. Whether circulating levels of WISP-1/CCN4 in humans are altered in obesity and/or type 2 diabetes (T2DM) and in the postprandial state, however, is unknown. This study assessed circulating WISP-1/CCN4 levels in a) paired liquid meal tests and hyperinsulinemic- euglycemic clamps (cohort I, n = 26), b) healthy individuals (cohort II, n = 207) and c) individuals with different stages of obesity and glucose tolerance (cohort III, n = 253)...
November 11, 2017: Journal of Cell Communication and Signaling
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