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Autism spectrum disorder females

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https://www.readbyqxmd.com/read/28429618/the-clinician-perspective-on-sex-differences-in-autism-spectrum-disorders
#1
Rene Jamison, Somer L Bishop, Marisela Huerta, Alycia K Halladay
Research studies using existing samples of individuals with autism spectrum disorders have identified differences in symptoms between males and females. Differences are typically reported in school age and adolescence, with similarities in symptom presentation at earlier ages. However, existing studies on sex differences are significantly limited, making it challenging to discern if, how, and at what point in development females with autism spectrum disorder actually exhibit a different behavioral presentation than males...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28418479/associations-of-maternal-antidepressant-use-during-the-first-trimester-of-pregnancy-with-preterm-birth-small-for-gestational-age-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-in-offspring
#2
Ayesha C Sujan, Martin E Rickert, A Sara Öberg, Patrick D Quinn, Sonia Hernández-Díaz, Catarina Almqvist, Paul Lichtenstein, Henrik Larsson, Brian M D'Onofrio
Importance: Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective: To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants: This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed up through 2013 or censored by death or emigration...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28417276/assessing-asd-in-adolescent-females-with-anorexia-nervosa-using-clinical-and-developmental-measures-a-preliminary-investigation
#3
Heather Westwood, William Mandy, Mima Simic, Kate Tchanturia
The aim of this study was to use standardised, clinical assessment tools to explore the presence of Autism Spectrum Disorder (ASD) symptoms in a sample of adolescent females with Anorexia Nervosa (AN), receiving either day-patient or inpatient treatment for their eating disorder and to determine whether any such symptoms were present during the early developmental period, a requirement for a diagnosis of ASD. Using a cross-sectional design, 40 females aged between 12 and 18 were recruited from inpatient and day-patient eating disorder services...
April 17, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28411125/hypersociability-in-the-angelman-syndrome-mouse-model
#4
David C Stoppel, Matthew P Anderson
Deletions and reciprocal triplications of the human chromosomal 15q11-13 region cause two distinct neurodevelopmental disorders. Maternally-derived deletions or inactivating mutations of UBE3A, a 15q11-13 gene expressed exclusively from the maternal allele in neurons, cause Angelman syndrome, characterized by intellectual disability, motor deficits, seizures, and a characteristic increased social smiling, laughing, and eye contact. Conversely, maternally-derived triplications of 15q11-13 cause a behavioral disorder on the autism spectrum with clinical features that include decreased sociability that we recently reconstituted in mice with Ube3a alone...
April 11, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28402749/mental-health-concerns-and-insurance-denials-among-transgender-adolescents
#5
Leena Nahata, Gwendolyn P Quinn, Nicole M Caltabellotta, Amy C Tishelman
PURPOSE: Transgender youth are at high risk for mental health morbidities. Based on treatment guidelines, puberty blockers and gender-affirming hormone therapy should be considered to alleviate distress due to discordance between an individual's assigned sex and gender identity. The goals of this study were to examine the: (1) prevalence of mental health diagnoses, self-injurious behaviors, and school victimization and (2) rates of insurance coverage for hormone therapy, among a cohort of transgender adolescents at a large pediatric gender program, to understand access to recommended therapy...
April 12, 2017: LGBT Health
https://www.readbyqxmd.com/read/28401654/is-there-sexual-dimorphism-of-hyperserotonemia-in-autism-spectrum-disorder
#6
Lauren C Shuffrey, Stephen J Guter, Shannon Delaney, Suma Jacob, George M Anderson, James S Sutcliffe, Edwin H Cook, Jeremy Veenstra-VanderWeele
Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as a quantitative trait have revealed sexual dimorphism. Few studies have examined the presence of a sex difference on hyperserotonemia within ASD. To assess whether the rate of hyperserotonemia is different in males than in females with ASD, we measured whole blood 5-HT levels in 292 children and adolescents with ASD, the largest sample in which this biomarker has been assessed...
April 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28397802/the-connectomes-of-males-and-females-with-autism-spectrum-disorder-have-significantly-different-white-matter-connectivity-densities
#7
Andrei Irimia, Carinna M Torgerson, Zachary J Jacokes, John D Van Horn
Autism spectrum disorder (ASD) encompasses a set of neurodevelopmental conditions whose striking sex-related disparity (with an estimated male-to-female ratio of 4:1) remains unknown. Here we use magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) to identify the brain structure correlates of the sex-by-ASD diagnosis interaction in a carefully selected cohort of 110 ASD patients (55 females) and 83 typically-developing (TD) subjects (40 females). The interaction was found to be predicated primarily upon white matter connectivity density innervating, bilaterally, the lateral aspect of the temporal lobe, the temporo-parieto-occipital junction and the medial parietal lobe...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389756/reducing-listening-related-stress-in-school-aged-children-with-autism-spectrum-disorder
#8
Gary Rance, Donella Chisari, Kerryn Saunders, Jean-Loup Rault
High levels of stress and anxiety are common in children with Autism Spectrum Disorder (ASD). Within this study of school-aged children (20 male, 6 female) we hypothesised that functional hearing deficits (also pervasive in ASD) could be ameliorated by auditory interventions and that, as a consequence, stress levels would be reduced. The use of Ear-Level Remote Microphone devices and Classroom Amplification systems resulted in significantly improved listening, communication and social interaction and a reduction in physiologic stress levels (salivary cortisol) in both one-on-one and group listening situations...
April 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28376324/social-attention-and-autism-symptoms-in-high-functioning-women-with-autism-spectrum-disorders
#9
Mieke P Ketelaars, Anne In't Velt, Audrey Mol, Hanna Swaab, Fenne Bodrij, Sophie van Rijn
BACKGROUND: Research has suggested a different, less visible, clinical manifestation of Autism Spectrum Disorders (ASD) in females. There is, however, limited research into possible underlying mechanisms explaining the female phenotype. AIMS: This study investigates social attention in females with ASD. METHODS AND PROCEDURES: 26 women diagnosed with ASD and 26 typical female controls were shown three video clips containing intense emotions...
April 1, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28374929/age-related-differences-in-prevalence-of-autism-spectrum-disorder-symptoms-in-children-and-adolescents-with-costello-syndrome
#10
David D Schwartz, Jennifer M Katzenstein, Eric J Highley, Deborah L Stabley, Katia Sol-Church, Karen W Gripp, Marni E Axelrad
Dysregulation of the mitogen activated protein kinase (MAPK) pathway in Costello syndrome (CS) may contribute to increased risk for autism-spectrum disorder (ASD). We examined prevalence of ASD symptoms in 14 individuals (six females) age 1-18 years with molecularly confirmed CS. Caregivers completed the Modified Checklist for Autism in Toddlers (M-CHAT) for ages 0-4 years (n = 7), and the Social Communication Questionnaire (SCQ) for ages 4 and older (n = 7). Age was associated with meeting ASD criteria: 5/7 (71...
May 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28373848/the-current-status-of-the-ketogenic-diet-in-psychiatry
#11
REVIEW
Emmanuelle C S Bostock, Kenneth C Kirkby, Bruce V M Taylor
BACKGROUND: The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the 1920s. It has been researched in a variety of neurological conditions in both animal models and human trials. The aim of this review is to clarify the potential role of KD in psychiatry. METHODS: Narrative review of electronic databases PubMED, PsychINFO, and Scopus. RESULTS: The search yielded 15 studies that related the use of KD in mental disorders including anxiety, depression, bipolar disorder, schizophrenia, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28371743/atypical-sensory-profiles-as-core-features-of-adult-adhd-irrespective-of-autistic-symptoms
#12
D Bijlenga, J Y M Tjon-Ka-Jie, F Schuijers, J J S Kooij
BACKGROUND: Abnormal sensory sensitivity is a feature of autism-spectrum disorder (ASD), but is also reported in attention-deficit/hyperactivity disorder (ADHD). In many cases, ADHD and ASD are comorbid. This study investigated the prevalence of sensory hyper- and hyposensitivity among adults with ADHD, controlling for autistic symptoms. METHOD: One hundred and sixteen adults diagnosed with ADHD completed the Adolescent/Adult Sensory Profile-NL (AASP-NL) and the Autism-spectrum Quotient (AQ) questionnaires...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28369850/an-mri-study-of-the-corpus-callosum-in-monkeys-developmental-trajectories-and-effects-of-neonatal-hippocampal-and-amygdala-lesions
#13
Christa Payne, Laetitia Cirilli, Jocelyne Bachevalier
This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week-2 years of age; eight additional infants (4 males) were scanned once at 1-4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months...
May 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28367671/the-diagnosis-of-autism-and-autism-spectrum-disorder-in-low-and-middle-income-countries-experience-from-jamaica
#14
Maureen Samms-Vaughan, Mohammad H Rahbar, Aisha S Dickerson, Katherine A Loveland, Manouchehr Hessabi, Deborah A Pearson, Jan Bressler, Sydonnie Shakespeare-Pellington, Megan L Grove, Charlene Coore-Desai, Jody Reece, Eric Boerwinkle
The administration requirements of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised, widely used in high-income countries, make them less feasible for diagnosis of autism spectrum disorder in low- and middle-income countries. The flexible administration requirements of the Childhood Autism Rating Scale have resulted in its use in both high-income countries and low- and middle-income countries. This study examines the agreement between assessments using the Childhood Autism Rating Scale with those using the Autism Diagnostic Observation Schedule or Autism Diagnostic Observation Schedule, Second Edition and Autism Diagnostic Interview-Revised in Jamaica...
March 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28361913/multi-scale-radiomic-analysis-of-sub-cortical-regions-in-mri-related-to-autism-gender-and-age
#15
Ahmad Chaddad, Christian Desrosiers, Matthew Toews
We propose using multi-scale image textures to investigate links between neuroanatomical regions and clinical variables in MRI. Texture features are derived at multiple scales of resolution based on the Laplacian-of-Gaussian (LoG) filter. Three quantifier functions (Average, Standard Deviation and Entropy) are used to summarize texture statistics within standard, automatically segmented neuroanatomical regions. Significance tests are performed to identify regional texture differences between ASD vs. TDC and male vs...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28353224/what-have-proteomic-studies-taught-us-about-novel-drug-targets-in-autism
#16
Paul C Guest, Daniel Martins-de-Souza
Autism spectrum disorders (ASDs) are a heterogeneous group of conditions with complex behavioural phenotypes. Although ASDs show a high rate of heritability, genetic research alone has not provided a complete understanding of the underlying causes. Recent developments using imaging techniques and proteomic-based molecular profiling approaches have now begun to generate new insights into the underlying pathways affected in both the brain and the periphery in individuals with these conditions. Of potential high importance is the constant finding of gender-specific biomarker profiles in ASD patients...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28347488/targeted-interneuron-depletion-in-the-dorsal-striatum-produces-autism-like-behavioral-abnormalities-in-male-but-not-female-mice
#17
Maximiliano Rapanelli, Luciana Romina Frick, Meiyu Xu, Stephanie Mary Groman, Kantiya Jindachomthong, Nobuaki Tamamaki, Chiyoko Tanahira, Jane Rebecca Taylor, Christopher Pittenger
BACKGROUND: Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FSIs) and the large cholinergic interneurons (CINs), are affected in patients with TS and in preclinical models of both ASD and TS. METHODS: To test the causal importance of these neuronal abnormalities, we recapitulated them in vivo in developmentally normal mice using a combination transgenic-viral strategy for targeted toxin-mediated ablation...
February 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28342163/brief-report-sexual-attraction-and-relationships-in-adolescents-with-autism
#18
Tamara May, Ken C Pang, Katrina Williams
Past research suggests more variation in sexual attraction in Autism Spectrum Disorder (ASD) using clinical samples. This study utilised a population representative group of 14/15 year olds from the Longitudinal Study of Australian Children. Ninety-four adolescents (73 males, 21 females) with ASD and 3454 (1685 males, 1675 females) without self-reported on sexual attraction and past sexual relationships. Females with ASD reported lower rates of heterosexual preference (adjusted odds ratio: 0.14, p < ...
March 24, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28341015/impairment-of-social-function-in-young-females-with-recent-onset-anorexia-nervosa-and-recovered-individuals
#19
Mette Bentz, Jens Richardt Moellegaard Jepsen, Tine Pedersen, Cynthia M Bulik, Lennart Pedersen, Anne Katrine Pagsberg, Kerstin J Plessen
PURPOSE: A subgroup of individuals with anorexia nervosa (AN) displays social difficulties; however, it is not clear if individuals with comorbid autism spectrum disorders account for these difficulties. METHODS: We compared social function using the Autism Diagnostic Observation Schedule in 43 young females with first-episode AN who did not have comorbid autism spectrum disorder, 28 individuals recovered from adolescent-onset AN, and 41 healthy comparison individuals (age range 14-22 years)...
January 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28326792/-i-was-just-so-different-the-experiences-of-women-diagnosed-with-an-autism-spectrum-disorder-in-adulthood-in-relation-to-gender-and-social-relationships
#20
Lucie Kanfiszer, Fran Davies, Suzanne Collins
Existing literature exploring autism spectrum disorders within female populations predominantly utilises quantitative methodology. A limited number of small-scale, qualitative studies have explored the experiences of adolescent girls with autism spectrum disorder, but adult women have remained largely unheard. This study aims to broaden the stories told within autobiographical literature and empower those within the wider community of women with autism spectrum disorder. In doing so, it seeks to extend existing conceptualisations of experience to include socially and culturally located factors...
March 1, 2017: Autism: the International Journal of Research and Practice
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