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Autism spectrum disorder females

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https://www.readbyqxmd.com/read/29787855/dysbiosis-of-microbiome-and-probiotic-treatment-in-a-genetic-model-of-autism-spectrum-disorders
#1
Tabouy Laure, Getselter Dimitry, Ziv Oren, Karpuj Marcela, Tabouy Timothée, Maayouf Rasha, Werbner Nir, Ben-Amram Hila, Nuriel-Ohayon Meital, Koren Omry, Elliott Evan
Recent studies have determined that the microbiome has direct effects on behavior, and may be dysregulated in neurodevelopmental conditions. Considering that neurodevelopmental conditions, such as autism, have a strong genetic etiology, it is necessary to understand if genes associated with neurodevelopmental disorders, such as Shank3, can influence the gut microbiome, and if probiotics can be a therapeutic tool. In this study, we have identified dysregulation of several genera and species of bacteria in the gut and colon of both male and female Shank3 KO mice...
May 19, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29777472/circumscribed-interests-and-attention-in-autism-the-role-of-biological-sex
#2
Clare Harrop, Desiree Jones, Shuting Zheng, Sallie Nowell, Brian A Boyd, Noah Sasson
Recent studies suggest that circumscribed interests (CI) in females with Autism Spectrum Disorder (ASD) may align more closely with interests reported in typical female development than those typically reported for ASD males. We used eye-tracking to quantify attention to arrays containing combinations of male, female and neutral images in elementary-aged males and females with and without ASD. A number of condition × sex effects emerged, with both groups attending to images that corresponded with interests typically associated with their biological sex...
May 18, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29762671/motor-impairments-correlate-with-social-deficits-and-restricted-neuronal-loss-in-an-environmental-model-of-autism
#3
Tareq Al Sagheer, Obelia Haida, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Pierre-Olivier Fernagut, Mohamed Jaber
Background: Motor impairments are amongst the earliest and most consistent signs of autism spectrum disorders (ASD) but are not used as diagnostic criteria. In addition, the relationship between motor and cognitive impairments and their respective neural substrates remain unknown. Methods: Here, we aimed at determining whether a well-acknowledged animal model of ASD, the valproic acid (VPA) model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas...
May 12, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29752658/cytoplasmic-fmrp-interacting-protein-1-2-cyfip1-2-expression-analysis-in-autism
#4
Rezvan Noroozi, Mir Davood Omrani, Arezou Sayad, Mohammad Taheri, Soudeh Ghafouri-Fard
Cytoplasmic FMRP interacting proteins 1 and 2 (CYFIP1/2) have been previously shown to be associated with central nervous system (CNS) disorders such as autism spectrum disorder (ASD). Moreover, dysregulation of their expression levels results in disturbances in CNS maturation and neuronal interconnections. In the present study, we compared expression levels of CYFIP1/2 in peripheral blood of 30 ASD patients and 41 healthy subjects by means of real time PCR. Expression analysis showed significant over-expression of CYFIP1/2 in ASD patients compared with healthy subjects (Fold change = 3...
May 11, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29752629/brief-report-gender-and-age-of-diagnosis-time-trends-in-children-with-autism-using-australian-medicare-data
#5
Tamara May, Katrina Williams
Recent evidence suggests the male predominance in Autism Spectrum Disorder (ASD) may be decreasing. Secondary analyses of Australian Medicare data (paediatrician/child psychiatrist items for diagnosing ASD before age 13) were used (N = 73,463 unique children from 1-July-2008 to 30-June-2016). Cumulative incidence of ASD in 4-year-olds in 2015/2016 was 1.10% [95% CI 1.06-1.14], males 1.66% [95% CI 1.60-1.72] and females 0.51% [95% CI 0.47-0.55]. New diagnoses significantly increased in older (5-12 years) males and females but not younger (0-4 years) children, from 2010/2011 to 2015/2016...
May 11, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29748736/long-term-social-skills-group-training-for-children-and-adolescents-with-autism-spectrum-disorder-a-randomized-controlled-trial
#6
Ulf Jonsson, Nora Choque Olsson, Christina Coco, Anders Görling, Oskar Flygare, Anna Råde, Qi Chen, Steve Berggren, Kristiina Tammimies, Sven Bölte
Social skills group training (SSGT) is widely used for intellectually able children and adolescents with autism spectrum disorder (ASD). Previous studies indicate small to moderate effects on social communication capacities. The duration of most available programs is relatively short, and extended training might lead to further improvement. This randomized controlled trial compared an extended 24-week version of the SSGT program KONTAKT with standard care. The weekly sessions gradually shifted in content from acquisition of new skills to real-world application of the acquired skills...
May 10, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29741976/self-reported-autism-spectrum-disorder-symptoms-among-adults-referred-to-a-gender-identity-clinic
#7
Lieke E W Vermaat, Anna I R van der Miesen, Annelou L C de Vries, Thomas D Steensma, Arne Popma, Peggy T Cohen-Kettenis, Baudewijntje P C Kreukels
PURPOSE: The purpose of this study was to (1) investigate autism spectrum disorder (ASD) symptoms in a sample of adults referred for gender dysphoria (GD) compared to typically developing (TD) populations, (2) see whether males assigned at birth with GD (MaBGD s) and females assigned at birth with GD (FaBGD s) differ in ASD symptom levels, (3) study the role of sexual orientation, and (4) investigate ASD symptoms' correlation with GD symptoms. METHODS: The Autism-Spectrum Quotient (AQ) was used to measure ASD symptoms, and the Utrecht Gender Dysphoria Scale (UGDS) was used to measure the intensity of GD...
May 9, 2018: LGBT Health
https://www.readbyqxmd.com/read/29736809/prevalence-of-the-wish-to-be-of-the-opposite-gender-in-adolescents-and-adults-with-autism-spectrum-disorder
#8
Anna I R van der Miesen, Hannah Hurley, Anneloes M Bal, Annelou L C de Vries
Several studies have suggested an overrepresentation of (symptoms of) autism spectrum disorder (ASD) among individuals with gender dysphoria. Three studies have taken the inverse approach in children with ASD and showed increased parent report of the wish to be of the opposite gender in this group. This study compared the self-reported wish to be of the opposite gender (one item of the Youth Self-Report [YSR] and the Adult Self-Report [ASR]) of 573 adolescents (469 assigned boys and 104 assigned girls) and 807 adults (616 assigned males and 191 assigned females) with ASD to 1016 adolescents and 846 adults from the general population...
May 7, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29730431/mayer-rokitansky-kuster-hauser-syndrome-and-16p11-2-recurrent-microdeletion-a-case-report-and-review-of-the-literature
#9
Marta Gatti, Gianluca Tolva, Silvia Bergamaschi, Claudia Giavoli, Susanna Esposito, Paola Marchisio, Donatella Milani
BACKGROUND: Mayer-Rokitansky-Kuster-Hauser syndrome (OMIM #277000) is a rare disorder of the female reproductive tract. Its etiology is still unknown for the majority of patients, even if the genetic background of this condition has been intensively studied. Chromosome 16p11.2 deletion syndrome (OMIM # 611913) is a well-known recurrent deletion syndrome that can present with various clinical phenotypes, including developmental delay, intellectual disability, autism spectrum disorder, obesity, and an increased frequency of congenital defects...
May 3, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29717186/novel-nexmif-pathogenic-variant-in-a-boy-with-severe-autistic-features-intellectual-disability-and-epilepsy-and-his-mildly-affected-mother
#10
Nelle Lambert, Corinne Dauve, Emmanuelle Ranza, Periklis Makrythanasis, Federico Santoni, Frédérique Sloan-Béna, Stefania Gimelli, Jean-Louis Blouin, Michel Guipponi, Armand Bottani, Stylianos E Antonarakis, Markus M Kosel, Joel Fluss, Ariane Paoloni-Giacobino
Intellectual disability (ID) and autism spectrum disorders are complex neurodevelopmental disorders occurring among all ethnic and socioeconomic groups. Pathogenic variants in the neurite extension and migration factor (NEXMIF) gene (formerly named KIAA2022) on the X chromosome are responsible for ID, autistic behavior, epilepsy, or dysmorphic features in males. Most affected females described had a milder phenotype or were asymptomatic obligate carriers. We report here for the first time mother-to-son transmission of a novel NEXMIF truncating variant without X-inactivation skewing in the blood...
May 1, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29713261/transcranial-direct-current-stimulation-tdcs-can-modulate-eeg-complexity-of-children-with-autism-spectrum-disorder
#11
Jiannan Kang, Erjuan Cai, Junxia Han, Zhen Tong, Xin Li, Estate M Sokhadze, Manuel F Casanova, Gaoxiang Ouyang, Xiaoli Li
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which affects the developmental trajectory in several behavioral domains, including impairments of social communication, cognitive and language abilities. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, and it was used for modulating the brain disorders. In this paper, we enrolled 13 ASD children (11 males and 2 females; mean ± SD age: 6.5 ± 1.7 years) to participate in our trial. Each patient received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) once every 2 days...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29704141/2d-4d-ratio-in-neurodevelopmental-disorders-a-twin-study
#12
Lynnea Myers, Annelies Van't Westeinde, Ralf Kuja-Halkola, Kristiina Tammimies, Sven Bölte
The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex...
April 27, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29701730/prevalence-of-autism-spectrum-disorder-among-children-aged-8-years-autism-and-developmental-disabilities-monitoring-network-11-sites-united-states-2014
#13
Jon Baio, Lisa Wiggins, Deborah L Christensen, Matthew J Maenner, Julie Daniels, Zachary Warren, Margaret Kurzius-Spencer, Walter Zahorodny, Cordelia Robinson Rosenberg, Tiffany White, Maureen S Durkin, Pamela Imm, Loizos Nikolaou, Marshalyn Yeargin-Allsopp, Li-Ching Lee, Rebecca Harrington, Maya Lopez, Robert T Fitzgerald, Amy Hewitt, Sydney Pettygrove, John N Constantino, Alison Vehorn, Josephine Shenouda, Jennifer Hall-Lande, Kim Van Naarden Braun, Nicole F Dowling
PROBLEM/CONDITION: Autism spectrum disorder (ASD). PERIOD COVERED: 2014. DESCRIPTION OF SYSTEM: The Autism and Developmental Disabilities Monitoring (ADDM) Network is an active surveillance system that provides estimates of the prevalence of autism spectrum disorder (ASD) among children aged 8 years whose parents or guardians reside within 11 ADDM sites in the United States (Arizona, Arkansas, Colorado, Georgia, Maryland, Minnesota, Missouri, New Jersey, North Carolina, Tennessee, and Wisconsin)...
April 27, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29696527/prevalence-and-characteristics-of-autism-spectrum-disorder-among-spanish-school-age-children
#14
Paula Morales-Hidalgo, Joana Roigé-Castellví, Carmen Hernández-Martínez, Núria Voltas, Josefa Canals
The present study aims to assess the prevalence of autism spectrum disorder (ASD) in preschool and school-age children following a two-phase procedure. The screening phase was performed on a sample of 5555 children taking into account parent and teacher information. The individual assessment included the ADI-R, ADOS-2 and Wechsler scales. The estimated prevalence was 1.55% in preschoolers and 1.00% in school-age children. Between 1.84 and 2.59% of the children exhibited subclinical diagnosis. The male-to-female ratio was around 4:1...
April 25, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29681085/two-novel-cases-expanding-the-phenotype-of-setd2-related-overgrowth-syndrome
#15
Maartje C van Rij, Iris H I M Hollink, Paulien Anna Terhal, Sarina G Kant, Claudia Ruivenkamp, Arie van Haeringen, J Anneke Kievit, Martine J van Belzen
The SETD2-related overgrowth syndrome is also called "Luscan-Lumish syndrome" (OMIM 616831) with the clinical characteristics of intellectual disability, speech delay, macrocephaly, facial dysmorphism, and autism spectrum disorders. We report on two novel patients a 4.5-year-old boy and a 23-year-old female adolescent with a speech and language developmental delay, autism spectrum disorder and macrocephaly, who were both diagnosed with SETD2-related overgrowth syndrome due to de novo frameshift mutations in the SETD2 gene...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29672866/the-development-of-autistic-social-traits-across-childhood-and-adolescence-in-males-and-females
#16
William Mandy, Liz Pellicano, Beate St Pourcain, David Skuse, Jon Heron
BACKGROUND: Autism is a dimensional condition, representing the extreme end of a continuum of social competence that extends throughout the general population. Currently, little is known about how autistic social traits (ASTs), measured across the full spectrum of severity, develop during childhood and adolescence, including whether there are developmental differences between boys and girls. Therefore, we sought to chart the trajectories of ASTs in the general population across childhood and adolescence, with a focus on gender differences...
April 19, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29662527/stimulant-withdrawal-in-a-child-with-autism-spectrum-disorder-and-adhd-a-case-report
#17
Aneta Krakowski, Abel Ickowicz
Objective: To consider whether the concepts of tolerance and withdrawal to stimulant medications apply to a preadolescent female, affected by autism spectrum disorder (ASD) and treated for associated attention-deficit/hyperactivity disorder (ADHD). Methods: We describe the case history and review scientific English language literature pertaining to acute withdrawal effects associated with methylphenidate and amphetamine derivatives in children. Results: An 11-year-old female with ASD and ADHD referred to our clinic experienced vomiting, headaches, and light sensitivity following abrupt discontinuation of methylphenidate; she subsequently presented with migraines and marked malaise immediately after a dose reduction in lisdexamfetamine...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29659141/risk-and-protective-factors-underlying-depression-and-suicidal-ideation-in-autism-spectrum-disorder
#18
Darren Hedley, Mirko Uljarević, Kitty-Rose Foley, Amanda Richdale, Julian Trollor
BACKGROUND: People with Autism Spectrum Disorder (ASD) are at significantly increased risk of suicidal thoughts and behavior. Given that social difficulties in ASD often lead to social isolation, which can in turn increase the risk for depression, this study examined loneliness and social support as potential risk and protective factors associated with depression and suicidal ideation. METHOD: The sample comprised 185 people (92 females) with ASD aged 14 to 80 years who were participating in a national survey...
April 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29655594/no-effect-of-prenatal-vitamin-d-deficiency-on-autism-relevant-behaviours-in-multiple-inbred-strains-of-mice
#19
M Langguth, M Fassin, S Alexander, K M Turner, T H J Burne
Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders commonly characterised by verbal and non-verbal communication deficits, impaired social interaction and repetitive, stereotypic behaviours. The aetiology of ASD is most likely a combination of genetic and environmental factors. Epidemiological evidence suggests that prenatal vitamin D deficiency is associated with an increased incidence of ASD. The overall aim of this study was to investigate prenatal vitamin D deficiency on ASD-related behavioural phenotypes in multiple inbred strains of mice...
April 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29651330/analysis-of-neuroanatomical-differences-in-mice-with-genetically-modified-serotonin-transporters-assessed-by-structural-magnetic-resonance-imaging
#20
Jacob Ellegood, Yohan Yee, Travis M Kerr, Christopher L Muller, Randy D Blakely, R Mark Henkelman, Jeremy Veenstra-VanderWeele, Jason P Lerch
Background: The serotonin (5-HT) system has long been implicated in autism spectrum disorder (ASD) as indicated by elevated whole blood and platelet 5-HT, altered platelet and brain receptor and transporter binding, and genetic linkage and association findings. Based upon work in genetically modified mice, 5-HT is known to influence several aspects of brain development, but systematic neuroimaging studies have not previously been reported. In particular, the 5-HT transporter (serotonin transporter, SERT; 5-HTT) gene, Slc6a4 , has been extensively studied...
2018: Molecular Autism
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