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https://www.readbyqxmd.com/read/29463075/adverse-effects-of-doping-with-anabolic-androgenic-steroids-aas-in-competitive-athletics-recreational-sports-and-bodybuilding
#1
Elena Vorona, Eberhard Nieschlag
Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes und haemoglobin concentration, which may lead to thromboembolism, intracardiac thrombosis and stroke...
February 19, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29462175/effect-of-cataract-surgery-on-cognitive-function-in-elderly-results-of-fujiwara-kyo-eye-study
#2
Kimie Miyata, Tadanobu Yoshikawa, Masayuki Morikawa, Masashi Mine, Nozomi Okamoto, Norio Kurumatani, Nahoko Ogata
PURPOSE: To determine whether there is a significant association between prior cataract surgery and cognitive function in an elderly Japanese cohort. SETTING: Nara Medical University, Nara, Japan. DESIGN: The Fujiwara-kyo Eye Study was a cross-sectional epidemiological study. METHODS: The subjects were ≥ 68-years who lived in the Nara Prefecture and responded to recruitment notices. All of the subjects received comprehensive ophthalmological examinations, and answered questionnaires on their socio-demographic and medical history including prior cataract surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29454341/treatment-of-depression-with-chai-hu-shu-gan-san-a-systematic-review-and-meta-analysis-of-42-randomized-controlled-trials
#3
Yan Sun, Xia Xu, Jinping Zhang, Yuanyuan Chen
BACKGROUND: Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. METHODS: Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017...
February 17, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29451587/diagnosing-dementia-in-lower-educated-older-persons-validation-of-a-brazilian-portuguese-version-of-the-rowland-universal-dementia-assessment-scale-rudas
#4
Narahyana B de Araujo, Thomas R Nielsen, Knut Engedal, Maria L Barca, Evandro S Coutinho, Jerson Laks
OBJECTIVE: To validate the Rowland Universal Dementia Assessment Scale for use in Brazil (RUDAS-BR). METHODS: We first completed an English-Brazilian Portuguese translation and back-translation of the RUDAS. A total of 135 subjects over 60 years of age were included: 65 cognitively healthy and 70 with Alzheimer's disease (AD) according to the DSM-IV and Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29451321/predicting-recovery-in-acute-post-stroke-aphasia
#5
Argye E Hillis, Yuan Ye Beh, Rajani Sebastian, Bonnie Breining, Donna C Tippett, Amy Wright, Sadhvi Saxena, Chris Rorden, Leonardo Bonilha, Alexandra Basilakos, Grigori Yourganov, Julius Fridriksson
OBJECTIVE: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in four studies. METHODS: We report two longitudinal studies that identified two variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first six months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and selective serotonin reuptake inhibitor (SSRI) use...
February 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29449128/meta-analysis-on-the-association-between-brain-derived-neurotrophic-factor-polymorphism-rs6265-and-ischemic-stroke-poststroke-depression
#6
Mei-Hua Bao, Shu-Zhen Zhu, Xin-Zheng Gao, Hong-Shuo Sun, Zhong-Ping Feng
BACKGROUND: Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent...
February 13, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29445281/suicidal-drug-overdose-following-stroke-in-elderly-patients-a-retrospective-population-based-cohort-study
#7
Chun-Hung Chang, Shaw-Ji Chen, Chieh-Yu Liu, Hsin-Chi Tsai
Purpose: The purpose of this study was to investigate the incidence and risk of suicidal drug overdose (SDO) after stroke in older patients. Methods: We enrolled patients aged 60-99 years who were diagnosed with new-onset stroke between 2002 and 2013 and age-, sex-, and index-year-matched controls who did not have stroke. Patients with a history of SDO before enrollment were excluded. Both groups were observed until December 31, 2013. The primary end point was the occurrence of newly diagnosed SDO...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29439160/co-occurrence-of-depressive-symptoms-and-executive-dysfunction-after-stroke-associations-with-brain-pathology-and-prognosis
#8
Elles Douven, Pauline Aalten, Julie Staals, Syenna H J Schievink, Robert J van Oostenbrugge, Frans R J Verhey, Sebastian Köhler
OBJECTIVE: To examine, first, whether the co-occurrence of executive dysfunction (ED) and poststroke depression (PSD) shows different associations with neuroimaging markers and the course of depression and executive function, and second, whether it is associated with a different course on other cognitive domains and quality of life. METHODS: The present study included 245 stroke patients (35.9% female, mean age 67.5 years (SD=11.9). All patients completed neuropsychological and neuropsychiatric assessment 3 months poststroke, which were repeated at 6-month and 12-month follow-up...
February 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29438112/executive-functioning-and-daily-living-of-individuals-with-chronic-stroke-measurement-and-implications
#9
Lena Lipskaya-Velikovsky, Gabi Zeilig, Harold Weingarden, Clara Rozental-Iluz, Debbie Rand
Deficits in executive functioning (EF) are often still present at the chronic stage after stroke, which may negatively impact independent living. The objectives of this study were (a) to characterize the EF and independence in daily living of community-dwelling individuals with chronic stroke by using pen-and-paper and performance-based EF assessments, (b) to explore correlations between scores detected by different EF assessments and (c) to assess the correlations between EF and independence in basic activities of daily living (BADL) and instrumental activities of daily living (IADL)...
February 12, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29438084/polygenic-risk-for-depression-increases-risk-of-ischemic-stroke-from-the-stroke-genetics-network-study
#10
Sylvia Wassertheil-Smoller, Qibin Qi, Tushar Dave, Braxton D Mitchell, Rebecca D Jackson, Simin Liu, Ki Park, Joel Salinas, Erin C Dunn, Enrique C Leira, Huichun Xu, Kathleen Ryan, Jordan W Smoller
BACKGROUND AND PURPOSE: Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis. METHODS: We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association study of ischemic stroke in the Stroke Genetics Network of National Institute of Neurological Disorders and Stroke...
February 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29434802/an-investigation-of-the-mechanism-of-dexmedetomidine-in-improving-postoperative-cognitive-dysfunction-from-the-perspectives-of-alleviating-neuronal-mitochondrial-membrane-oxidative-stress-and-electrophysiological-dysfunction
#11
Jie Chen, Na Shen, Xiaohui Duan, Yaning Guo
The aim of this study was to investigate the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction. A total of 120 patients undergoing elective surgery under general anesthesia from June 2013 to May, 2016 were selected as the subjects of the study and randomly divided into the propofol + remifentanil and dexmedetomidine groups. The Rey Auditory Verbal Learning Test (AVLT) and Beck Depression Inventory (BDI) were performed at day 1 before operation and at day 1, 3, 5 and 15 after operation...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432698/long-term-depression-induced-by-endogenous-cannabinoids-produces-neuroprotection-via-astroglial-cb1r-after-stroke-in-rodents
#12
Feng Wang, Jing Han, Haruki Higashimori, Jingyi Wang, Jingjing Liu, Li Tong, Yongjie Yang, Hailong Dong, Xia Zhang, Lize Xiong
Ischemia not only activates cell death pathways but also triggers endogenous protective mechanisms. However, it is largely unknown what is the essence of the endogenous neuroprotective mechanisms induced by preconditioning. In this study we demonstrated that systemic injection of JZL195, a selective inhibitor of eCB clearance enzymes, induces in vivo long-term depression at CA3-CA1 synapses and at PrL-NAc synapses produces neuroprotection. JZL195-elicited long-term depression is blocked by AM281, the antagonist of cannabinoid 1 receptor (CB1R) and is abolished in mice lacking cannabinoid CB1 receptor (CB1R) in astroglial cells, but is conserved in mice lacking CB1R in glutamatergic or GABAergic neurons...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29431126/repetitive-transcranial-magnetic-stimulation-for-depression-after-basal-ganglia-ischaemic-stroke-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial
#13
Ying Tang, Aimin Chen, Shuzhen Zhu, Li Yang, Jiyuan Zhou, Suyue Pan, Min Shao, Lianxu Zhao
INTRODUCTION: Studies suggest that repetitive transcranial magnetic stimulation (rTMS) is effective for the treatment of depression and promotes the repair of white matter. This study aims to assess the effectiveness of rTMS in treating depression after basal ganglia ischaemic stroke and to examine whether such effects are related to restoration of white matter integrity. METHODS AND ANALYSIS: Sixty-six participants will be recruited from Zhujiang Hospital, Nanfang Hospital and Sichuan Bayi Rehabilitation Hospital and randomised in a 1:1 ratio to receive active rTMS treatment or sham rTMS treatment in addition to routine supportive treatments...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29429905/health-related-quality-of-life-in-patients-with-poststroke-epilepsy
#14
Yaroslav Winter, Naeimeh Daneshkhah, Nikolaus Galland, Isabel Kotulla, Anna Krüger, Sergiu Groppa
BACKGROUND: Lesional epilepsy is an important long-term sequela of stroke. Data on health-related quality of life (HrQoL) in patients with poststroke epilepsy are limited. We investigated HrQoL in patients with epilepsy after ischemic stroke and identified independent HrQoL-determinants. METHODS AND PATIENTS: All patients with acute ischemic stroke, who were permanent residents in the district Marburg-Biedenkopf (Hessia, Germany, reference population 240,000 inhabitants) were recruited within 12months in the population-based Marburg Stroke Register (MARSTREG)...
February 8, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29427767/an-assessment-of-the-relationship-of-physical-activity-obesity-and-chronic-diseases-conditions-between-active-obese-and-sedentary-normal-weight-american-women-in-a-national-sample
#15
J R Pharr, C A Coughenour, T J Bungum
OBJECTIVE: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. STUDY DESIGN: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data...
February 7, 2018: Public Health
https://www.readbyqxmd.com/read/29425407/the-importance-of-understanding-the-underlying-physiology-of-exercise-when-designing-exercise-interventions-for-brain-health
#16
Ashleigh E Smith, Ashlee M Hendy, Gavin D Tempest
The societal and economic costs of conditions associated with brain pathology (for example depression, dementia and stroke) are ever increasing. This article is protected by copyright. All rights reserved.
February 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29423535/the-population-impact-of-rheumatic-and-musculoskeletal-diseases-in-relation-to-other-non-communicable-disorders-comparing-two-estimation-approaches
#17
Daniela Simões, Fábio Azevedo Araújo, Teresa Monjardino, Milton Severo, Ivo Cruz, Loreto Carmona, Raquel Lucas
The aim of this study was to quantify the population impact of rheumatic and musculoskeletal diseases (RMDs) with other non-communicable diseases (NCDs), using two complementary strategies: standard multivariate models based on global burden of disease (GBD)-defined groups vs. empirical mutually exclusive patterns of NCDs. We used cross-sectional data from the Portuguese Fourth National Health Survey (n = 23,752). Six GBD-defined groups were included: RMDs, chronic obstructive pulmonary disease or asthma, cancer, depression, diabetes or renal failure, and stroke or myocardial infarction...
February 8, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29423385/association-of-the-anxiety-depression-with-nutrition-intake-in-stroke-patients
#18
Yoonji Kim, Myung-Chul Kim, Hang-Sik Park, Il-Hoon Cho, Jean Kyung Paik
Stroke patients often experience a walking dysfunction caused by decreased mobility, weakened muscular strength, abnormal posture control, and cognitive dysfunction. Anxiety/depression is the most important and prevalent neuropsychiatric complication of stroke survivors. Brain injury and the presence of malnutrition after stroke contribute to metabolic status and clinical outcome of patients. We examined the level of nutrition intake in stroke patients according to their degree of anxiety/depression. The data were obtained from 2013 to 2015 through the Korea National Health and Nutrition Examination Survey (KNHANES)...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29422883/detecting-cortical-spreading-depolarization-with-full-band-scalp-electroencephalography-an-illusion
#19
Jeannette Hofmeijer, C R van Kaam, Babette van de Werff, Sarah E Vermeer, Marleen C Tjepkema-Cloostermans, Michel J A M van Putten
Introduction: There is strong evidence suggesting detrimental effects of cortical spreading depolarization (CSD) in patients with acute ischemic stroke and severe traumatic brain injury. Previous studies implicated scalp electroencephalography (EEG) features to be correlates of CSD based on retrospective analysis of EEG epochs after having detected "CSD" in time aligned electrocorticography. We studied the feasibility of CSD detection in a prospective cohort study with continuous EEG in 18 patients with acute ischemic stroke and 18 with acute severe traumatic brain injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29422379/relation-among-psychopathological-symptoms-neuropsychological-domains-and-functional-disability-in-subacute-poststroke-rehabilitation
#20
Viviana Lo Buono, Lilla Bonanno, Rosanna Palmeri, Francesco Corallo, Sergio Parisi, Antonia Trinchera, Edoardo Sessa, Patrizia Pollicino, Bruno Galletti, Placido Bramanti, Silvia Marino
BACKGROUND: Neuropsychiatric disorders are commonly observed in patients following a stroke. Among 30%-60% of poststroke patients suffer from depression and anxiety (18%-25%). Some authors suggest an association between psychological symptoms and lesions in specific brain areas. In particular, lesions in left frontal cortex and left basal ganglia are frequently associated with poststroke depression and with comorbidity of anxiety and depression, whereas isolated anxiety symptoms are frequently observed after right hemispheric lesions...
February 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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