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stroke and depression

Shenshen Li, James A Blumenthal, Chuan Shi, Danielle Millican, Xian Li, Xin Du, Anushka Patel, Pei Gao, Elizabeth Delong, Pallab K Maulik, Runlin Gao, Xin Yu, Yangfeng Wu
Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrate depression care into the management of ACS patients to reduce depression and improve ACS outcomes are critically needed. Integrating Depression Care in ACS patients in Low Resource Hospitals in China (I-CARE) is a multicenter, randomized controlled trial to evaluate the efficacy of an 11-month integrated care (IC) intervention compared to usual care (UC) in management of ACS patients...
May 21, 2018: American Heart Journal
Chen-Chen Zhang, Fang Lu, Jia-Qiang Liang, Yan-Fang Zhou
The protein acetylation by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a significant role in the development and maturation of the nervous system. HDAC6, belonging to class II HDACs, by regulating the survival, differentiation and maturation of neural cells, plays an important role in the development of the nervous system and participates in multiple pathological processes of cerebral ischemic injury. In addition, HDAC6 participates in the regulation of cognition and emotion of the brain...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Pavlos Texakalidis, Stefanos Giannopoulos, Damianos G Kokkinidis, Giuseppe Lanzino
PURPOSE: To compare periprocedural complications and in-stent restenosis rates associated with open- vs closed-cell stent designs used in carotid artery stenting (CAS). METHODS: A systematic search was conducted to identify all randomized and observational studies published in English up to October 31, 2017, that compared open- vs closed-cell stent designs in CAS. Identified studies were included if they reported the following outcomes: stroke, transient ischemic attack (TIA), myocardial infarction (MI), hemodynamic depression, new ischemic lesions detected on imaging, and death within 30 days, as well as the incidence of in-stent restenosis...
June 1, 2018: Journal of Endovascular Therapy
Hande Gezer, Ozgur Zeliha Karaahmet, Eda Gurcay, Deniz Dulgeroglu, Aytul Cakci
BACKGROUND AND AIMS: To compare the effects of aerobic exercise and conventional exercise that were applied during the rehabilitation process on the aerobic capacity, motor function, activity limitation, quality of life, depression level, and sleep quality in subacute stroke patients. METHODS: The patients were divided into two groups; aerobic exercise group (n = 22) or conventional exercise group (n = 20). Both groups participated in a conventional stroke rehabilitation program; however, aerobic exercise program was applied only for the patients in group 1...
June 19, 2018: Irish Journal of Medical Science
Barbara Grabowska-Fudala, Krystyna Jaracz, Krystyna Górna, Izabela Miechowicz, Izabela Wojtasz, Jan Jaracz, Radosław Kaźmierski
INTRODUCTION: This is a prospective study, first to compare the frequency of depressive symptoms in stroke survivors treated, and non-treated, with intravenous thrombolysis and second, to explore relationships between post-stroke depression (PSD) and stroke treatment modalities, taking into account other possible determinants of PSD, including post-traumatic stress symptoms. METHODS: Groups of 73 thrombolysed and 73 non-thrombolysed patients matched for age and gender were examined at 3 and 12 months after discharge...
June 18, 2018: Journal of Neurology
Kyungjoon Lee, Inah Kim
Background: As job stress is associated with various diseases and psychiatric conditions, we aimed to estimate the job stress-attributable burden of disease in Korea based on the concept of disability-adjusted life years (DALY). Methods: We selected ischemic heart disease (IHD), stroke, major depressive disorder (MDD), and suicide as health outcomes from job stress, because of the ease of access to data estimating burdens and of important meaning of them in Korean occupational background...
June 18, 2018: Journal of Korean Medical Science
Yusuf Olgar, Sinan Degirmenci, Aysegul Durak, Deniz Billur, Belgin Can, Gizem Kayki Mutlu, Ebru Arioglu Inan, Belma Turan
Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose...
June 13, 2018: Experimental Gerontology
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
Gianni Allais, Giulia Chiarle, Silvia Sinigaglia, Gisella Airola, Paola Schiapparelli, Chiara Benedetto
Migraine has a predilection for female sex and the course of symptoms is influenced by life stage (presence of menstrual cycle, pregnancy, puerperium, menopause) and use of hormone therapy, such as hormonal contraception and hormone replacement therapy. Hormonal changes figure among common migraine triggers, especially sudden estrogen drop. Moreover, estrogens can modulate neuronal excitability, through serotonin, norepinephrine, dopamine, and endorphin regulation, and they interact with the vascular endothelium of the brain...
June 2018: Neurological Sciences
Min-Young Kim, Seunghoon Lee, You Ho Myong, Yoon Jae Lee, Me-Riong Kim, Joon-Shik Shin, Jinho Lee, In-Hyuk Ha
OBJECTIVES: Although sleep, chronic disease and its related mortality are extensively studied areas, the association between stroke and sleep duration is relatively unknown. The aim of this study was to investigate the association between long and short sleep duration and stroke prevalence. DESIGN: A cross-sectional survey study. SETTING AND PARTICIPANTS: Adult surveyees (aged ≥19 years) who answered items relating to sleep duration and stroke in the 2010-2014 Korean National Health and Nutrition Surveys (n=17 601)...
June 14, 2018: BMJ Open
Nicola Veronese, Jacopo Demurtas, Stefano Celotto, Maria Gabriella Caruso, Stefania Maggi, Francesco Bolzetta, Joseph Firth, Lee Smith, Patricia Schofield, Ai Koyanagi, Lin Yang, Marco Solmi, Brendon Stubbs
BACKGROUND & AIMS: The literature regarding the potential health benefits of chocolate consumption are unclear and the epidemiological credibility has not been systematically scrutinized, while the strength of the evidence is undetermined. We therefore aimed to map and grade the diverse health outcomes associated with chocolate consumption using an umbrella review of systematic reviews. METHODS: Umbrella review of systematic reviews of observational and intervention studies (randomized placebo-controlled trials, RCTs)...
June 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Xiaoqin Duan, Gang Yao, Zhongliang Liu, Ranji Cui, Wei Yang
Post-stroke depression (PSD) is a neuropsychiatric affective disorder that can develop after stroke. Patients with PSD show poorer functional and recovery outcomes than patients with stroke who do not suffer from depression. The risk of suicide is also higher in patients with PSD. PSD appears to be associated with complex pathophysiological mechanisms involving both psychological and psychiatric problems that are associated with functional deficits and neurochemical changes secondary to brain damage. Transcranial magnetic stimulation (TMS) is a non-invasive way to investigate cortical excitability via magnetic stimulation of the brain...
2018: Frontiers in Human Neuroscience
Sripal Bangalore, Ruchit Shah, Elizabeth Pappadopulos, Chinmay G Deshpande, Ahmed Shelbaya, Rita Prieto, Jennifer Stephens, Roger S McIntyre
Aims: The association between depression care adequacy and the risk of subsequent adverse cardiovascular disease (CVD) outcomes among patients with a previous diagnosis of myocardial infarction (MI) or stroke is not well defined. Methods and Results: This retrospective cohort study used commercial claims data (2010-2015) and included adults with newly diagnosed and treated MDD following an initial MI or stroke diagnosis. Depression care adequacy was assessed during the 3-month period following the MDD diagnosis index date using two measures: antidepressant dosage adequacy and duration adequacy...
June 11, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
Linda P Bolin, Carolyn E Horne, Patricia B Crane, James R Powell
AIMS AND OBJECTIVES: The aim of this study was to identify health and physiological measures, depressive symptoms and locus of control (LOC) in adherence to a low salt (1500 mg sodium), diet in African American (AA) adults with hypertension (HTN). BACKGROUND: Adherence determinants to self-management behaviors among AA adults with HTN is essential in prevention of outcomes such as stroke. A low salt diet is one key factor in the successful management of HTN. DESIGN: A cross sectional correlational design...
June 12, 2018: Journal of Clinical Nursing
Tamara Tse, Thomas Linden, Leonid Churilov, Stephen Davis, Geoffrey Donnan, Leeanne M Carey
RESEARCH QUESTION: 1. Does activity participation improve over time in the first year after stroke? 2. What is the association of depressive symptoms on retained activity participation 12-months post-stroke adjusting for neurological stroke severity and age? 3. Is an improvement in activity participation associated with a decrease in depressive symptoms between 3- and 12-months post-stroke? DESIGN: Longitudinal observational study of activity participation and depressive symptoms in ischemic stroke survivors...
June 11, 2018: Disability and Rehabilitation
Alexandra M J Denham, Sean Halpin, Laura Twyman, Ashleigh Guillaumier, Billie Bonevski
OBJECTIVE: The prevalence of modifiable health risk factors and psychological distress following a stroke is high and markedly increase the chance of a second stroke. This study aimed to examine the usability and acceptability of an online secondary prevention program addressing modifiable psycho-behavioural risk factors for stroke survivors. METHODS: A pre-post pilot study was conducted in Australia between 2016 and 2017. Participants were recruited through the Australian Stroke Clinical Registry and completed measures of health-related quality of life, physical activity, smoking status, depression and anxiety, alcohol status, nutrition and internet use...
June 11, 2018: Australian and New Zealand Journal of Public Health
Eun-Jae Lee, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim, Ji Sung Lee
BACKGROUND AND PURPOSE: The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual's mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. METHODS: This study involved a post hoc analysis of data from EMOTION ( NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke...
May 2018: Journal of Stroke
Alessandra Sussulini, Rachel Ann Hauser-Davis
Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiology of these illnesses is not completely established and multiple factors are involved, metallomics, a bioanalytical strategy that allows the detection of metal ions and metalloproteins in diverse biological matrices, is of extreme relevance in identifying which elements are affected by a disease and/or treatment...
2018: Advances in Experimental Medicine and Biology
Andrew J Whalen, Ying Xiao, Herve Kadji, Markus A Dahlem, Bruce J Gluckman, Steven J Schiff
Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other active molecules, collapsing the resting membrane electro-chemical gradient of cells leading to spike inactivation and cellular swelling, and propagates independently of synaptic transmission. We demonstrate the modulation, suppression and prevention of spreading depression utilizing applied transcortical DC electric fields in brain slices, measured with intrinsic optical imaging and potassium dye epifluorescence...
June 8, 2018: Scientific Reports
Anna E Kirkland, Gabrielle L Sarlo, Kathleen F Holton
Magnesium is well known for its diverse actions within the human body. From a neurological standpoint, magnesium plays an essential role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity), and has been implicated in multiple neurological disorders. Due to these important functions within the nervous system, magnesium is a mineral of intense interest for the potential prevention and treatment of neurological disorders...
June 6, 2018: Nutrients
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