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Genital human papillomavirus in men

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https://www.readbyqxmd.com/read/29208707/recurring-infection-with-ecologically-distinct-hpv-types-can-explain-high-prevalence-and-diversity
#1
Sylvia L Ranjeva, Edward B Baskerville, Vanja Dukic, Luisa L Villa, Eduardo Lazcano-Ponce, Anna R Giuliano, Greg Dwyer, Sarah Cobey
The high prevalence of human papillomavirus (HPV), the most common sexually transmitted infection, arises from the coexistence of over 200 genetically distinct types. Accurately predicting the impact of vaccines that target multiple types requires understanding the factors that determine HPV diversity. The diversity of many pathogens is driven by type-specific or "homologous" immunity, which promotes the spread of variants to which hosts have little immunity. To test for homologous immunity and to identify mechanisms determining HPV transmission, we fitted nonlinear mechanistic models to longitudinal data on genital infections in unvaccinated men...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29165581/acquisition-persistence-and-clearance-of-human-papillomavirus-infection-among-male-virgins-residing-in-brazil-mexico-and-the-united-states
#2
Zhiyue Liu, Alan G Nyitray, Lu-Yu Hwang, Michael D Swartz, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L Villa, Anna R Giuliano
Background: Little is known about the natural history of HPV infection in male virgins. This study estimated incidence and clearance of genital HPV, and factors associated with HPV, among men who deny ever engaging in penetrative sex at baseline. Methods: A cohort of 4123 men residing in Brazil, Mexico, and the USA were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis...
November 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29063590/the-prevalence-and-concordance-of-human-papillomavirus-infection-in-different-anogenital-sites-among-men-and-women-in-liuzhou-china-a-population-based-study
#3
Feixue Wei, Mingqiang Li, Xin Wu, Kai Yin, Jian Lan, Wei Sheng, Meng Guo, Shoujie Huang, Ying Wang, Yanping Li, Rongcheng Li, Yingying Su, Ting Wu, Jun Zhang, Ningshao Xia
Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2309 men and 2378 women aged 18-55 were enrolled from a community in Liuzhou, China. Penis/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) specimens of men, and vaginal (VA), vulvar (VU) and PA specimens of women, were collected and genotyped for HPV...
October 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29063507/awareness-and-knowledge-levels-of-18-year-old-and-older-individuals-regarding-human-papillomavirus-hpv-and-hpv-vaccine-in-hatay-turkey
#4
Ebru Turhan, Sirin Cetin, Meryem Cetin, Fatma Abacigil
The aim of this study was to evaluate the knowledge and awareness levels of 18-year-old and older women and men on HPV infection, HPV vaccine, and the potential risk factors in Hatay, Turkey. In our study, it was found that overall 27.0 and 23.2% of the participants reported having heard of HPV infection and HPV vaccine. The rate of participants who had heard of HPV infection and HPV vaccine was higher in women than in men (p < 0.000). Thirteen percent of the participants was aware of the fact that HPV triggers cervical cancer, 10...
October 23, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29049523/oral-human-papillomavirus-infection-differences-in-prevalence-between-sexes-and-concordance-with-genital-human-papillomavirus-infection-nhanes-2011-to-2014
#5
Kalyani Sonawane, Ryan Suk, Elizabeth Y Chiao, Jagpreet Chhatwal, Peihua Qiu, Timothy Wilkin, Alan G Nyitray, Andrew G Sikora, Ashish A Deshmukh
Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown. Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U.S...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28956542/prevalence-genotype-distribution-and-temporal-dynamics-of-human-papillomavirus-infection-in-a-population-in-southern-italy
#6
Raffaele Del Prete, Luigi Ronga, Grazia Addati, Raffaella Magrone, Domenico Di Carlo, Giuseppe Miragliotta
Human papillomavirus (HPV) is considered the most important risk factor for the development of ano-genital region cancer in both women and men. Whereas low-risk genotypes are responsible for cutaneous and genital lesions, high-risk genotypes are associated with ano-genital cancer. The aim of this study was to retrospectively analyse the prevalence, genotype distribution and temporal dynamics of HPV infection in 2312 specimens from 2312 subjects (2149 women and 163 men) who attended the laboratory of molecular biology, UOC Microbiology and Virology, Azienda Ospedaliera-Universitaria, Policlinico of Bari, Italy...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28956458/9-valent-human-papillomavirus-vaccine-a-review-of-the-clinical-development-program
#7
Alain Luxembourg, Erin Moeller
The 9-valent human papillomavirus (9vHPV) vaccine covers the same HPV types (6/11/16/18) as the quadrivalent HPV (qHPV) vaccine and 5 additional cancer-causing types (31/33/45/52/58). Epidemiological studies indicate that the 9vHPV vaccine could prevent approximately 90% of cervical cancers, 70-85% of high-grade cervical dysplasia (precancers), 85-95% of HPV-related vulvar, vaginal, and anal cancers, and 90% of genital warts. Areas covered: Study design features and key findings from the 9vHPV vaccine clinical development program are reviewed...
October 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28953412/sexually-transmitted-infections-active-component-u-s-armed-forces-2007-2016
#8
Shauna Stahlman, Alexis A Oetting
This report summarizes incidence rates of the five most commonly diagnosed sexually transmitted infections (STIs) among active component service members of the U.S. Armed Forces during 2007-2016. Chlamydia diagnoses were the most common, followed in decreasing order of frequency by diagnoses associated with genital human papillomavirus (HPV), gonorrhea, herpes simplex virus (HSV), and syphilis. Compared to men, women had higher rates of all STIs except for syphilis. In general, compared to their respective counterparts, younger service members, non-Hispanic blacks, soldiers, and enlisted members had higher incidence rates of STIs...
September 2017: MSMR
https://www.readbyqxmd.com/read/28898279/lifestyle-factors-and-oncogenic-papillomavirus-infection-in-a-high-risk-male-population
#9
Elena Lopez-Diez, Sonia Perez, Manuel Carballo, Amparo Iñarrea, Angel de la Orden, Maximo Castro, Moises Rodríguez, Sheila Almuster, Ruben Montero, Miguel Perez, Jorge Sanchez, Antonio Ojea
BACKGROUND: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28893935/tumour-virus-vaccines-hepatitis-b-virus-and-human-papillomavirus
#10
REVIEW
Margaret Stanley
Two of the most important human oncogenic viruses are hepatitis B virus (HBV) and human papillomavirus (HPV). HBV infection has been preventable by vaccination since 1982; vaccination of neonates and infants is highly effective, resulting already in decreased rates of new infections, chronic liver disease and hepato-cellular carcinoma. Nonetheless, HBV remains a global public health problem with high rates of vertical transmission from mother to child in some regions. Prophylactic HPV vaccines composed of virus-like particles (VLPs) of the L1 capsid protein have been licensed since 2006/2007...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28876311/human-immunodeficiency-virus-status-differentially-associated-with-genital-and-anal-human-papillomavirus-infection-among-chinese-men-who-have-sex-with-men-a-cross-sectional-survey
#11
Han-Zhu Qian, Yifei Hu, James G Carlucci, Lu Yin, Xiangwei Li, Anna R Giuliano, Dongliang Li, Lei Gao, Yiming Shao, Sten H Vermund
BACKGROUND: Little is known about human papillomavirus (HPV) infection and genotypes when considering both anatomic site and human immunodeficiency virus (HIV) status among men who have sex with men (MSM) in low- and middle-income countries. METHODS: A cross-sectional study was conducted among MSM in Beijing, China. HIV serostatus was determined, and genital and anal HPV genotyping were performed from respective swabs. RESULTS: Of 1155 MSM, 817 (70...
November 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28866637/detection-of-human-papillomavirus-in-urine-among-heterosexual-men-in-relation-to-location-of-genital-warts-and-circumcision-status
#12
Ei T Aung, Christopher K Fairley, Sepehr N Tabrizi, Jennifer A Danielewski, Jason J Ong, Marcus Y Chen, Catriona S Bradshaw, Eric P F Chow
OBJECTIVE: Human papillomavirus (HPV) surveillance is important to monitor the effectiveness of national HPV vaccination programmes. Positivity of HPV in urine in men varies with different sampling methods. We aimed to determine the positivity for detection of HPV-6/11 in urine samples among men in relation to the position of genital warts and circumcision status. METHOD: We analysed stored chlamydia-positive urine specimens in young heterosexual men aged less than 25 years attending Melbourne Sexual Health Centre, Australia, between 2004 and 2015, for HPV genotypes...
September 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28832285/prevalence-of-anogenital-hpv-infection-related-disease-and-risk-factors-among-hiv-infected-men-in-inner-city-johannesburg-south-africa-baseline-findings-from-a-cohort-study
#13
Admire Chikandiwa, Lucy Chimoyi, Pedro T Pisa, Matthew F Chersich, Etienne E Muller, Pamela Michelow, Philippe Mayaud, Sinead Delany-Moretlwe
BACKGROUND: Persistent high-risk human papillomavirus (HR-HPV) infection is associated with the development of anogenital cancers, particularly in men living with HIV (MLWH). We describe the prevalence of anogenital HPV infection, abnormal anal cytology and anogenital warts (AGWs) in MLWH in Johannesburg, and explore whether HPV infection and receipt of antiretroviral treatment is associated with detection of abnormal anal cytology and AGWs. METHODS: We enrolled a cohort of 304 sexually-active MLWH ≥18 years, who completed a questionnaire and physical examination...
July 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28815421/knowledge-beliefs-and-attitudes-of-somali-men-in-olmsted-county-minnesota-u-s-on-the-human-papillomavirus-vaccine-and-cervical-cancer-screening-january-17-2015
#14
Uzoma Abakporo, Abdirahman Hussein, James W Begun, Tetyana Shippee
This study explores the general knowledge of Human Papillomavirus vaccine (HPV) and cervical cancer screening (CCS) among Somali men in the U.S., who are major decision-makers in Somali households. HPV infects both men and women, and causes genital warts and cervical cancer (CC). High mortality from CC persists among minorities due to low uptake of preventive tools. Eleven questions assessed general knowledge of HPV and CCS among 30 Somali male respondents. The knowledge of HPV and CCS by education level, age, and years lived in the U...
August 16, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28806741/risk-of-cancer-in-patients-with-genital-warts-a-nationwide-population-based-cohort-study-in-taiwan
#15
Ching-Yi Cho, Yu-Cheng Lo, Miao-Chiu Hung, Chou-Cheng Lai, Chun-Jen Chen, Keh-Gong Wu
BACKGROUND: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. METHODS AND FINDINGS: Between January 2000 and December 2013, approximately 3 million patients were reported to the National Health Insurance Research Database of Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28798073/the-human-papillomavirus-replication-cycle-and-its-links-to-cancer-progression-a-comprehensive-review
#16
REVIEW
Sheila V Graham
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. HPV infects dividing basal epithelial cells where its dsDNA episomal genome enters the nuclei. Upon basal cell division, an infected daughter cell begins the process of keratinocyte differentiation that triggers a tightly orchestrated pattern of viral gene expression to accomplish a productive infection...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28755837/missed-opportunities-for-catch-up-human-papillomavirus-vaccination-among-university-undergraduates-identifying-health-decision-making-behaviors-and-uptake-barriers
#17
Kathleen R Ragan, Robert A Bednarczyk, Scott M Butler, Saad B Omer
BACKGROUND: Suboptimal adolescent human papillomavirus (HPV) vaccine rates in the US highlight the need for catch-up vaccination. When teenagers enter college, there may be a shift in healthcare decision-making from parents and guardians to the students themselves. Little is known about factors influencing college students' healthcare decision-making processes. STUDY DESIGN: We evaluated HPV vaccine decision-making among 18-to-26-year-old college students through a self-administered, anonymous, cross-sectional survey...
July 26, 2017: Vaccine
https://www.readbyqxmd.com/read/28723467/human-papillomavirus-infection-and-vaccination-in-males
#18
REVIEW
Eugenio Ventimiglia, Simon Horenblas, Asif Muneer, Andrea Salonia
CONTEXT: Human papillomavirus (HPV) is the commonest sexually transmitted pathogen in humans and is linked to the aetiopathogenesis for both benign and malignant disease in men. OBJECTIVE: To evaluate and summarise the evidence for HPV infection and vaccination in men. EVIDENCE ACQUISITION: A search of Medline, PubMed, and Scopus was performed to identify articles published in English within the last 10 yr addressing HPV epidemiology, the natural history of HPV infection and its long-term consequences, and vaccination in men...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720451/high-diversity-of-alpha-beta-and-gamma-human-papillomaviruses-in-genital-samples-from-hiv-negative-and-hiv-positive-heterosexual-south-african-men
#19
Tracy L Meiring, Zizipho Z A Mbulawa, Maia Lesosky, David Coetzee, Anna-Lise Williamson
BACKGROUND: This study investigated the prevalence of HPVs in heterosexual South African men and the impact of HIV co-infection. METHODS: HPV was detected in penile swabs from 195 HIV-infected and 140 HIV-uninfected men using PCR with FAP59/64 primers and Roche Linear Array HPV genotyping (LA). Genotyping of FAP positive specimens was achieved by high-throughput sequencing of amplicons. RESULTS: HPV was detected by FAP PCR and LA in 79% (266/335) of the men...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28636869/association-between-sexual-mixing-and-genital-warts-in-heterosexual-men-in-australia-the-herd-protection-from-the-female-human-papillomavirus-vaccination-program
#20
Eric P F Chow, Christopher K Fairley
Australian-born women aged ≤32 years were eligible for the free female human papillomavirus (HPV) vaccination program introduced in 2007. A total of 1165 heterosexual couples attending the Melbourne Sexual Health Centre between 2011 and 2014 were included in this analysis. Findings showed the odds of having penile warts was 0.52-fold lower among men who had a female partner aged ≤32 years compared with men who had a female partners aged >32 years. This suggests men would have received herd protection from their female partners and hence they are at lower risk of acquiring genital warts...
October 2016: Sexual Health
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