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omega-3 fatty acids and depression

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https://www.readbyqxmd.com/read/27819485/pilot-randomized-controlled-trial-of-omega-3-and-individual-family-psychoeducational-psychotherapy-for-children-and-adolescents-with-depression
#1
Mary A Fristad, Anthony T Vesco, Andrea S Young, K Zachary Healy, Elias S Nader, William Gardner, Adina M Seidenfeld, Hannah L Wolfson, L Eugene Arnold
The goal of this study is to evaluate feasibility and estimate effect sizes of omega-3 fatty acids (Ω3), individual-family psychoeducational psychotherapy (PEP), their combination, and moderating effects of maternal depression and psychosocial stressors in youth with depression. In a pilot 2 × 2 randomized controlled trial, 72 youth (ages 7-14; 57% Caucasian, 57% male) with major depression, dysthymia, or depression not otherwise specified were randomized to 12 weeks of Ω3, PEP+placebo, Ω3+PEP, or placebo...
November 7, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27815837/fish-oil-prevents-lipopolysaccharide-induced-depressive-like-behavior-by-inhibiting-neuroinflammation
#2
Zhe Shi, Huixia Ren, Zhijian Huang, Yu Peng, Baixuan He, Xiaoli Yao, Ti-Fei Yuan, Huanxing Su
Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas...
November 4, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27812381/associations-between-omega-fatty-acid-consumption-and-depressive-symptoms-among-individuals-seeking-behavioural-weight-loss-treatment
#3
Anna K Luke, E Whitney Evans, Dale S Bond, J Graham Thomas
OBJECTIVE: The typical Western diet is deficient in omega-3 and high in omega-6 fatty acids (FAs). These FAs may play a role in depressive symptoms via inflammatory processes, especially in the context of obesity, a pro-inflammatory state. This study investigated associations between omega-3 and omega-6 FA intake and depressive symptoms in adults seeking behavioural weight loss treatment (BWLT). METHODS: One hundred eighty-eight persons with overweight or obesity (83...
March 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27806526/role-of-omega-3-unsaturated-fatty-acids-in-the-postpartum-depression-systematic-review-and-narrative-synthesis
#4
Fatima Mougharbel, Raywat Deonandan
BACKGROUND: Postpartum depression (PPD) is a complex mental health disorder that affects women during their childbearing years. It is a serious medical condition that occurs in approximately 15% of women after birth and has an adverse effect on both the mother and the infant. Hypotheses exist relating dietary deficiencies in a pregnant or postnatal woman's diet may cause postnatal depression. It is unclear whether Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are effective for treating or preventing PPD...
August 1, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27788314/reconsidering-dietary-polyunsaturated-fatty-acids-in-bipolar-disorder-a-translational-picture
#5
Erika F H Saunders, Christopher E Ramsden, Mostafa S Sherazy, Alan J Gelenberg, John M Davis, Stanley I Rapoport
Inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the proposed role of PUFA metabolism in neuroinflammation, modulation of brain PUFA metabolism by antimanic medications in rodent models, and anti-inflammatory pharmacotherapy in bipolar disorder and in major depressive disorder (MDD)...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27766299/role-of-omega-3-fatty-acids-in-the-etiology-treatment-and-prevention-of-depression-current-status-and-future-directions
#6
Robert K McNamara
Over the past three decades a body of translational evidence has implicated dietary deficiency in long-chain omega-3 (LCn-3) fatty acids, including eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of major depressive disorder (MDD). Cross-national and cross-sectional data suggest that greater habitual intake of preformed EPA+DHA is associated with reduced risk for developing depressive symptoms and syndromal MDD. Erythrocyte EPA and DHA composition is highly correlated with habitual fish or fish oil intake, and case-control studies have consistently observed lower erythrocyte EPA and/or DHA levels in patients with MDD...
September 2016: Journal of Nutrition & Intermediary Metabolism
https://www.readbyqxmd.com/read/27763934/omega-3-fatty-acids-clinical-applications-in-the-treatment-of-depression
#7
Stephanie Maxine Ross
No abstract text is available yet for this article.
November 2016: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27742581/oxidative-stress-predicts-depressive-symptom-changes-with-omega-3-fatty-acid-treatment-in-coronary-artery-disease-patients
#8
Graham Mazereeuw, Nathan Herrmann, Ana C Andreazza, Gustavo Scola, David W L Ma, Paul I Oh, Krista L Lanctôt
BACKGROUND: Antidepressant efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment in coronary artery disease (CAD) patients remains unpredictable. N-3 PUFA can mitigate oxidative stress, which is common in CAD and may contribute to depressive symptoms. This study investigated whether greater pre-treatment oxidative stress, measured by the ratios of late-stage lipid peroxidation markers (malondialdehyde [MDA], 4-hydroxy-2-nonenal [4-HNE], and 8-isoprostane [8-ISO]) to an early-stage marker (lipid hydroperoxides [LPH]), predicted n-3 PUFA antidepressant benefits in CAD...
October 11, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27689989/chlorella-sorokiniana-extract-improves-short-term-memory-in-rats
#9
Maria Grazia Morgese, Emanuela Mhillaj, Matteo Francavilla, Maria Bove, Lucia Morgano, Paolo Tucci, Luigia Trabace, Stefania Schiavone
Increasing evidence shows that eukaryotic microalgae and, in particular, the green microalga Chlorella, can be used as natural sources to obtain a whole variety of compounds, such as omega (ω)-3 and ω-6 polyunsatured fatty acids (PUFAs). Although either beneficial or toxic effects of Chlorella sorokiniana have been mainly attributed to its specific ω-3 and ω-6 PUFAs content, the underlying molecular pathways remain to be elucidated yet. Here, we investigate the effects of an acute oral administration of a lipid extract of Chlorella sorokiniana, containing mainly ω-3 and ω-6 PUFAs, on cognitive, emotional and social behaviour in rats, analysing possible underlying neurochemical alterations...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27651257/role-of-omega-3-pufas-in-neurobiological-health
#10
R Grant, J Guest
The importance of the essential, dietary-derived, polyunsaturated fatty acids (PUFAs) omega-6 and omega-3 to human health was first reported over 85 years ago. Subsequent research has revealed many beneficial effects of the omega-3 PUFAs in particular. This has been linked to their involvement in multiple biochemical functions, including synthesis of inflammatory mediators, cell membrane fluidity, intracellular signalling and gene expression. Through these pathways, the omega-3 PUFAs help modulate aspects of inflammation and immunity, cell growth and tissue repair...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27631140/omega-3-and-omega-6-polyunsaturated-fatty-acids-in-bipolar-disorder-a-review-of-biomarker-and-treatment-studies
#11
Erika F H Saunders, Christopher E Ramsden, Mostafa S Sherazy, Alan J Gelenberg, John M Davis, Stanley I Rapoport
OBJECTIVE: There is growing evidence that inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the data on PUFAs as biomarkers in bipolar disorder and n-3 PUFA used as treatment for bipolar disorder. DATA SOURCES: PubMed and CINAHL were searched for articles on PUFA and bipolar disorder published in the English language through November 6, 2013, with an updated search conducted on August 20, 2015...
September 13, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27630014/the-synchronized-trial-on-expectant-mothers-with-depressive-symptoms-by-omega-3-pufas-synchro-study-protocol-for-a-randomized-controlled-trial
#12
Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Yo Sano, Yoshiyuki Tachibana, Hiroe Ito, Keiich Isaka, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J Matsuoka
BACKGROUND: Maternal depression can be harmful to both mothers and their children. Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been investigated as an alternative intervention for pregnant women with depressive symptoms because of the supporting evidence from clinical trials in major depression, the safety advantage, and its anti-inflammatory and neuroplasticity effects. This study examines the efficacy of omega-3 PUFA supplementation for pregnant women with depressive symptoms in Taiwan and Japan, to provide evidence available for Asia...
September 15, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27621225/sex-specific-effects-of-docosahexaenoic-acid-dha-on-the-microbiome-and-behavior-of-socially-isolated-mice
#13
Daniel J Davis, Patrick M Hecht, Eldin Jasarevic, David Q Beversdorf, Matthew J Will, Kevin Fritsche, Catherine H Gillespie
Dietary supplementation with the long-chain omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been shown to have a beneficial effect on reducing the symptoms associated with several neuropsychiatric conditions including anxiety and depression. However, the mechanisms underlying this effect remain largely unknown. Increasing evidence suggests that the vast repertoire of commensal bacteria within the gut plays a critical role in regulating various biological processes in the brain and may contribute to neuropsychiatric disease risk...
September 9, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27608809/n-3-polyunsaturated-fatty-acids-through-the-lifespan-implication-for-psychopathology
#14
Matteo M Pusceddu, Philip Kelly, Catherine Stanton, John F Cryan, Timothy G Dinan
OBJECTIVE: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer's disease...
September 21, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27604240/psychoeducational-psychotherapy-and-omega-3-supplementation-improve-co-occurring-behavioral-problems-in-youth-with-depression-results-from-a-pilot-rct
#15
Andrea S Young, L Eugene Arnold, Hannah L Wolfson, Mary A Fristad
This pilot randomized controlled trial (RCT) investigated benefits of omega-3 fatty acid supplementation and Individual-Family Psychoeducational Psychotherapy (PEP; a family-focused, cognitive-behavioral therapy) for behavior problems among youth with depression. Participants aged 7-14 with DSM-IV-TR depressive disorders (N = 72; 56.9 % male) were randomized to 1 of 4 treatment conditions: PEP + omega-3, PEP monotherapy (with pill placebo), omega-3 monotherapy, or placebo (without active intervention)...
September 8, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27592324/there-is-no-association-between-the-omega-3-index-and-depressive-symptoms-in-patients-with-heart-disease-who-are-low-fish-consumers
#16
Shaoxin Cai, Alison M Coates, Jonathan D Buckley, Narelle M Berry, Lisa Burres, John Beltrame, Peter R C Howe, Geoffrey Schrader
BACKGROUND: Long chain Omega-3 polyunsaturated fatty acids (LCn3PUFAs) may improve cardiovascular health and depression. This study investigated the relationships between erythrocyte membrane LCn3PUFA status, depression and angina symptoms in patients with heart disease. METHODS: We recruited 91 patients (65 males and 26 females, mean age 59.2±10.3 years) with heart disease and depressive symptoms (Center for Epidemiological Studies Depression Scale, CES-D ≥ 16) and low fish/fish oil intakes...
August 16, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27558477/maternal-nutritional-imbalance-between-linoleic-acid-and-alpha-linolenic-acid-increases-offspring-s-anxious-behavior-with-a-sex-dependent-manner-in-mice
#17
Nobuyuki Sakayori, Hisanori Tokuda, Kaichi Yoshizaki, Hiroshi Kawashima, Sheila M Innis, Hiroshi Shibata, Noriko Osumi
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients for normal brain development. The principal dietary n-6 and n-3 PUFAs are linoleic acid (LA) and α-linolenic acid (ALA), respectively, We have previously shown that maternal dietary imbalance between these PUFAs, i.e., rich in LA and poor in ALA, affected brain development and increased anxiety-related behavior in the mouse offspring. Here we further addressed sex difference in anxiety-related behavior in the offspring exposed to maternal LA:ALA imbalance...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27529771/omega-3-fatty-acids-depressive-symptoms-and-cognitive-performance-in-patients-with-coronary-artery-disease-analyses-from-a-randomized-double-blind-placebo-controlled-trial
#18
Graham Mazereeuw, Nathan Herrmann, Paul I Oh, David W L Ma, Cheng Tao Wang, Alexander Kiss, Krista L Lanctôt
This trial investigated the efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment for improving depressive symptoms and cognitive performance in patients with coronary artery disease (CAD) participating in cardiac rehabilitation. Patients with CAD aged 45 to 80 years were randomized to receive either 1.9-g/d n-3 PUFA treatment or placebo for 12 weeks. Depressive symptoms were measured using the Hamilton Depression Rating Scale (HAM-D, primary outcome) and the Beck Depression Inventory II (BDI-II)...
October 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27506081/-biological-review-of-completed-suicide
#19
REVIEW
Ikuo Otsuka, Ichiro Sora, Akitoyo Hishimoto
Family, twin and adoption studies have revealed genetic factors involved in suicide, while the accumulation of stress and mental illnesses are major contributing factors of suicide. Since higher lethality of suicidal behavior is considered to increase familial liability to suicidal behavior, we believe biological research of completed suicide is most important for a better understanding of the pathophysiology in suicide. Dysregulated hypothalamic-pituitary-adrenal axis has gained a special interest in the neurobiology of suicide, mostly because of the findings using a dexamethasone suppression test (DST), in which DST non-suppressors show a nearly 10-fold higher risk of completed suicide than DST suppressors in a depressed cohort...
June 2016: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27496183/the-importance-of-n-6-n-3-fatty-acids-ratio-in-the-major-depressive-disorder
#20
REVIEW
Kristian Søborg Husted, Elena V Bouzinova
This review aims to clarify the relation between the ratio of omega-6 to omega-3 fatty acids and the development of depression. It is explained how these fatty acids are involved in the production of eicosanoids and how these fatty acids can affect the membrane fluidity, by their incorporation into membrane phospholipids. In addition, it is described how omega-3 derivatives are shown to regulate gene transcription. In view of the pathophysiology of depression, the mechanisms of how an altered ratio of omega-6 to omega-3 could be involved in depression are discussed...
2016: Medicina
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