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omega-3 fatty acids and depression

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https://www.readbyqxmd.com/read/29783176/%C3%AF-3-and-folic-acid-act-against-depressive-like-behavior-and-oxidative-damage-in-the-brain-of-rats-subjected-to-early-or-late-life-stress
#1
Gislaine Z Réus, Amanda L Maciel, Helena M Abelaira, Airam B de Moura, Thays G de Souza, Thais R Dos Santos, Ana Caroline Darabas, Murilo Parzianello, Danyela Matos, Mariane Abatti, Ana Carolina Vieira, Vanessa Fucillini, Monique Michels, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: To investigate the antidepressant and antioxidant effects of omega-3, folic acid and n-acetylcysteine (NAC) in rats which were subjected to early or late life stress. METHODS: Early stress was induced through maternal deprivation (MD), while late life stress was induced using the chronic mild stress (CMS) protocol. Young rats which were subjected to MD and the adult rats which were subjected to CMS were treated with omega-3 fatty acids (0.72 g/kg), NAC (20 mg/kg) or folic acid (50 mg/kg) once/day, for a period of 20 days...
March 30, 2018: Nutrition
https://www.readbyqxmd.com/read/29768974/brain-phospholipid-precursors-administered-post-injury-reduce-tissue-damage-and-improve-neurological-outcome-in-experimental-traumatic-brain-injury
#2
Orli Thau-Zuchman, Rita Noutel Gomes, Simon Christopher Dyall, Meirion Davis, John V Priestley, Martine Groenendijk, Martijn DE Wilde, Jordi Lopez-Tremoleda, Adina T Michael-Titus
Traumatic brain injury (TBI) leads to cellular loss, destabilisation of membranes, disruption of synapses and altered brain connectivity, and increased risk of neurodegenerative disease. A significant and long-lasting decrease in phospholipids (PL), essential membrane constituents, has recently been reported in plasma and brain tissue, in human and experimental TBI. We hypothesised that supporting PL synthesis post-injury could improve outcome after TBI. We tested this hypothesis using a multi-nutrient combination designed to support the biosynthesis of phospholipids and available for clinical use...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29710835/eicosahexanoic-acid-epa-and-docosahexanoic-acid-dha-in-muscle-damage-and-function
#3
REVIEW
Eisuke Ochi, Yosuke Tsuchiya
Nutritional supplementation not only helps in improving and maintaining performance in sports and exercise, but also contributes in reducing exercise fatigue and in recovery from exhaustion. Fish oil contains large amounts of omega-3 fatty acids, eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (DHA; 22:6 n-3). It is widely known that omega-3 fatty acids are effective for improving cardiac function, depression, cognitive function, and blood as well as lowering blood pressure. In the relationship between omega-3 fatty acids and exercise performance, previous studies have been predicted improved endurance performance, antioxidant and anti-inflammatory responses, and effectivity against delayed-onset muscle soreness...
April 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29651972/n-3-omega-3-fatty-acids-effects-on-brain-dopamine-systems-and-potential-role-in-the-etiology-and-treatment-of-neuropsychiatric-disorders
#4
Beth Levant, Michelle Healy-Stoffel
A number of neuropsychiatric disorders, including Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder, and, to some extent, depression, involve dysregulation of the brain dopamine systems. The etiology of these diseases is multifactorial, involving genetic and environmental factors. Evidence suggests that inadequate levels of n-3 (omega-3) polyunsaturated fatty acids (PUFA) in the brain may represent a risk factor for these disorders. These fatty acids, which are derived from the diet, are a major component of neuronal membranes and are of particular importance in brain development and function...
April 12, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29627596/omega-3-fatty-acids-for-a-better-mental-state-in-working-populations-happy-nurse-project-a-52-week-randomized-controlled-trial
#5
Norio Watanabe, Yutaka Matsuoka, Mie Kumachi, Kei Hamazaki, Masaru Horikoshi, Toshi A Furukawa
The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrolment...
April 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29602331/the-association-of-omega-3-fatty-acid-levels-with-personality-and-cognitive-reactivity
#6
Carisha S Thesing, Mariska Bot, Yuri Milaneschi, Erik J Giltay, Brenda W J H Penninx
OBJECTIVE: Low omega (n)-3 polyunsaturated fatty acid (PUFA) levels have been found in patients with various major psychiatric disorders. This study aims to identify whether psychological vulnerabilities (personality and cognitive reactivity) underlying these psychiatric conditions are also associated with n-3 PUFA blood levels. METHODS: Data was used from 2912 subjects (mean age 41.9 years, 66.4% female) from the Netherlands Study of Depression and Anxiety (NESDA)...
May 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29565163/-depressive-symptoms-and-serum-levels-of-polyunsaturated-fatty-acids-omega-3-and-omega-6-among-college-students-from-northern-mexico
#7
María Rubí Vargas, Efraín Alonso Terrazas-Medina, Ahideé Guadalupe Leyva-López, Sandra Lidia Peralta-Peña, Lea Aurora Cupul-Uicab
INTRODUCTION: Previous studies suggest that low consumption as well as low serum levels of polyunsaturated fatty acids (PUFA) omega-3 and a high omega-6/omega-3 ratio may be implicated in the etiology of depressive disorders, however, epidemiologic evidence is inconclusive. OBJECTIVE: To assess the relationship of serum levels of omega-3 fatty acids (docosahexaenoic [DHA], eicosapentaenoic [EPA], alpha-linolenic fatty acid [ALA]) and the omega-6 (arachidonic acid [AA])/EPA ratio with depressive symptoms among Mexican college students...
November 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29549496/exploring-the-association-between-whole-blood-omega-3-index-dha-epa-dha-aa-and-n-6-dpa-and-depression-and-self-esteem-in-adolescents-of-lower-general-secondary-education
#8
I S M van der Wurff, C von Schacky, T Bergeland, R Leontjevas, M P Zeegers, P A Kirschner, R H M de Groot
PURPOSE: Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE)...
March 16, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29540267/systematic-review-and-meta-analysis-of-omega-3-fatty-acids-in-elderly-patients-with-depression
#9
REVIEW
Ji-Hyun Bae, Gaeun Kim
One of the typical symptoms of a psychological crisis is depression, an increasing concern in the elderly population. Although omega-3-polyunsaturated fatty acids (PUFAs) are reported to be promising nutrients for treating depression, currently, there are no systematic reviews or meta-analyses of randomized control trials that provide critical evidence regarding the potential benefits of omega-3 fatty acids in elderly patients with depression. This analysis was conducted to provide evidence for the clinical application of omega-3 fatty acids in the treatment of depressive symptoms of elderly subjects older than 65 years...
February 2018: Nutrition Research
https://www.readbyqxmd.com/read/29526608/the-vitamin-d-and-omega-3-trial-depression-endpoint-prevention-vital-dep-rationale-and-design-of-a-large-scale-ancillary-study-evaluating-vitamin-d-and-marine-omega-3-fatty-acid-supplements-for-prevention-of-late-life-depression
#10
Olivia I Okereke, Charles F Reynolds, David Mischoulon, Grace Chang, Nancy R Cook, Trisha Copeland, Georgina Friedenberg, Julie E Buring, JoAnn E Manson
RATIONALE: Depression is a leading cause of disease burden and disability for older adults; thus, prevention is a priority. Biologic and observational data support potential mental health benefits of vitamin D and omega-3 fatty acids; however, it is unclear whether these supplements can prevent late-life depression. DESIGN: We describe the novel methodology of a large-scale study: VITAL-DEP (VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention), an ancillary to the VITAL trial...
May 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29494205/how-does-high-dha-fish-oil-affect-health-a-systematic-review-of-evidence
#11
Samaneh Ghasemi Fard, Fenglei Wang, Andrew J Sinclair, Glenn Elliott, Giovanni M Turchini
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content, have attracted much scientific attention in the last four decades. Fish oils that contain higher amounts of eicosapentaenoic acid (EPA; 20:5n-3) than docosahexaenoic acid (DHA; 22:6n-3), in a distinctive ratio of 18/12, are typically the most abundantly available and are commonly studied. Although the two fatty acids have traditionally been considered together, as though they were one entity, different physiological effects of EPA and DHA have recently been reported...
March 1, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29479787/cardiometabolic-risks-and-omega-3-index-in-recent-onset-bipolar-i-disorder
#12
Lawson R Wulsin, Thomas J Blom, Michelle Durling, Jeffrey A Welge, Melissa P DelBello, Caleb M Adler, Robert K McNamara, Stephen M Strakowski
OBJECTIVES: The aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels. METHODS: Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56)...
February 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29397559/anti-oxidative-effects-of-melatonin-receptor-agonist-and-omega-3-polyunsaturated-fatty-acids-in-neuronal-sh-sy5y-cells-deciphering-synergic-effects-on-anti-depressant-mechanisms
#13
Senthil Kumaran Satyanarayanan, Yin-Hwa Shih, Yu-Chuan Chien, Shih-Yi Huang, Piotr Gałecki, Siegfried Kasper, Jane Pei-Chen Chang, Kuan-Pin Su
Omega-3 polyunsaturated fatty acids (n-3 or omega-3 PUFAs) and melatonin receptor agonist ramelteon (RMT) both display antidepressant effects, while their cellular effects on anti-oxidative and neuroprotective mechanisms might be different. In this study, we aimed to decipher the individual and synergistic actions of n-3 PUFAs and RMT, as compared with the conventional antidepressant fluoxetine (FLX), in a cellular model of oxidative stress, which might play an important role in the pathophysiology of depression and associated disorders...
February 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29396909/comparative-study-of-different-polar-groups-of-epa-enriched-phospholipids-on-ameliorating-memory-loss-and-cognitive-deficiency-in-aged-samp8-mice
#14
Miao-Miao Zhou, Hong-Xia Che, Jia-Qi Huang, Tian-Tian Zhang, Jie Xu, Chang-Hu Xue, Yu-Ming Wang
SCOPE: Recent studies have shown that omega-3 PUFAs enriched phospholipids (n-3 PUFA-PLs) have beneficial effects on memory and cognition. However, most reports only attribute the benefit to docosahexaenoic acid (DHA) and pay little attention to eicosapentaenoic acid (EPA). METHODS AND RESULTS: We investigate the effect of EPA-enriched phospholipids on cognitive deficiency in senescence-accelerated prone 8 (SAMP8) mouse. Ten-month-old SAMP8 mice are fed with 2% (w/w) EPA-enriched phosphatidylcholine/phosphatidyl ethanolamine (EPA-PC/PE; EPA:DHA = 46...
April 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29350557/omega-3-polyunsaturated-fatty-acids-and-their-health-benefits
#15
Fereidoon Shahidi, Priyatharini Ambigaipalan
Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3). In the past few decades, many epidemiological studies have been conducted on the myriad health benefits of omega-3 PUFAs. In this review, we summarized the structural features, properties, dietary sources, metabolism, and bioavailability of omega-3 PUFAs and their effects on cardiovascular disease, diabetes, cancer, Alzheimer's disease, dementia, depression, visual and neurological development, and maternal and child health...
March 25, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29336895/alterations-in-peripheral-fatty-acid-composition-in-bipolar-and-unipolar-depression
#16
Gustavo Scola, Amelia Versace, Adam H Metherel, Luz A Monsalve-Castro, Mary L Phillips, Richard P Bazinet, Ana C Andreazza
BACKGROUND: Lipid metabolism has been shown to play an important role in unipolar and bipolar depression. In this study, we aimed to evaluate levels of fatty acids in patients with unipolar (MDD) and bipolar depression (BDD) in comparison to patients with bipolar disorder in euthymia (BDE) and non-psychiatric controls. METHODS: Levels of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) were assessed in serum of (87) patients with BD (31 euthymic, 22 depressive) or MDD (34) and (31) non-psychiatric controls through GC-FID...
June 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29321047/effects-of-concentrated-long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-before-radical-prostatectomy-on-prostate-cancer-proliferation-inflammation-and-quality-of-life-study-protocol-for-a-phase-iib-randomized-double-blind-placebo-controlled-trial
#17
Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising intervention for prostate cancer patients. The aim of the study is to evaluate the effects of long-chain omega-3 polyunsaturated fatty acids (LCn3), more precisely eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation, on prostate cancer proliferation, inflammation mediators and quality of life among men who will undergo radical prostatectomy...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29306057/the-effects-of-omega-3-and-vitamin-e-co-supplementation-on-parameters-of-mental-health-and-gene-expression-related-to-insulin-and-inflammation-in-subjects-with-polycystic-ovary-syndrome
#18
Mehri Jamilian, Azadeh Shojaei, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Maryam Karamali, Mohsen Taghizadeh, Hamidreza Jamilian, Somayeh Alaeinasab, Sadegh Jafarnejad, Zatollah Asemi
OBJECTIVE: The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). METHODS: Forty PCOS women were allocated into two groups and treated with 1000mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention...
March 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29278623/depression-and-heart-diseases-leading-health-problems
#19
Matea Raič
Depression is the most common psychiatric disorder in the world population and the most frequent mental disorder in a primary health care. Unrecognized and untreated depression is associated with a poor outcome of treated chronic diseases which co-exist with depression. Depression and cardiovascular diseases are bidirectional related conditions, risks are for each other, and they often co-exist. Depression is a common disorder in cardiovascular patients with a prevalence of 20% to 45%, which is much more frequent than in the general population...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29245334/fatty-acid-components-in-asian-female-patients-with-irritable-bowel-syndrome
#20
Chian Sem Chua, Shih-Yi Huang, Chiao-Wen Cheng, Chyi-Huey Bai, Chien-Yeh Hsu, Hung-Wen Chiu, Jung-Lung Hsu
Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS...
December 2017: Medicine (Baltimore)
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