G Paul Amminger, Simon Rice, Christopher G Davey, Amelia L Quinn, Daniel F Hermens, Natalia Zmicerevska, Alissa Nichles, Ian Hickie, Lisa Incerti, Amber Weller, Sarah Joseph, Zarah Hilton, Charlotte Pugh, Madeline Rayner, Nate Reid, Aswin Ratheesh, Alison R Yung, Hok Pan Yuen, Andrew Mackinnon, Sarah Hetrick, Alexandra Parker, Rebekah Street, Maximus Berger, Michael Berk, Patrick D McGorry, Ashleigh Lin
BACKGROUND: Clinical trials suggest long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA; 'fish oil') may reduce depressive symptoms in adults with MDD. Hence, n-3 PUFA may be a potential treatment for depression in youth. METHODS: Participants were aged 15-25 years with MDD who sought care in one of three government-funded mental health services for young people in metropolitan Melbourne, Perth, or Sydney, Australia. Participants were randomly assigned in a double-blind, parallel-arm design to receive 'fish oil' (840 mg of eicosapentaenoic acid and 560 mg of docosahexaenoic acid) or placebo capsules as adjunct to cognitive behavioural case management (CBCM)...
June 22, 2023: Biological Psychiatry