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https://www.readbyqxmd.com/read/29147953/impact-of-perfluorochemicals-on-human-health-and-reproduction-a-male-s-perspective
#1
REVIEW
C Foresta, S Tescari, A Di Nisio
Perfluoroalkyl compounds (PFCs) are a class of organic molecules used in industry and consumer products. PFCs are non-biodegradable and bioaccumulate in the environment and for these reasons they have been a major subject of research regarding their toxicity, environmental fate, and sources of human exposure, since they have been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity and immunotoxicity. The aim of this review is to explore the existing knowledge of the interplay between PFCs exposure and human health, with a focus on male reproductive health, given the emerging gender differences in PFCs clearance and their interaction with sex hormones receptors...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29146197/illicit-drug-ketamine-induces-adverse-effects-from-behavioral-alterations-and-oxidative-stress-to-p53-regulated-apoptosis-in-medaka-fish-under-environmentally-relevant-exposures
#2
Pei-Han Liao, Wen-Kai Yang, Ching-Hsin Yang, Chun-Hon Lin, Chin-Chu Hwang, Pei-Jen Chen
With increasing problems of drug abuse worldwide, aquatic ecosystems are contaminated by human pharmaceuticals from the discharge of hospital or municipal effluent. However, ecotoxicity data and related toxic mechanism for neuroactive controlled or illicit drugs are still lacking, so assessing the associated hazardous risk is difficult. This study aims to investigate the behavioral changes, oxidative stress, gene expression and neurotoxic or apoptosis effect(s) in larvae of medaka fish (Oryzias latipes) with environmentally relevant exposures of ketamine (KET) solutions for 1-14 days...
November 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29138404/neonicotinoid-pesticide-limits-improvement-in-buzz-pollination-by-bumblebees
#3
P R Whitehorn, C Wallace, M Vallejo-Marin
Neonicotinoid pesticides have been linked to global declines of beneficial insects such as bumblebees. Exposure to trace levels of these chemicals causes sub-lethal effects, such as reduced learning and foraging efficiency. Complex behaviours may be particularly vulnerable to the neurotoxic effects of neonicotinoids. Such behaviours may include buzz pollination (sonication), in which pollinators, usually bees, use innate and learned behaviours to generate high-frequency vibrations to release pollen from flowers with specialised anther morphologies...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137973/exposure-to-polybrominated-diphenyl-ethers-pbdes-and-child-behavior-current-findings-and-future-directions
#4
REVIEW
Ann M Vuong, Kimberly Yolton, Kim N Dietrich, Joseph M Braun, Bruce P Lanphear, Aimin Chen
Polybrominated diphenyl ethers (PBDEs) are recognized neurotoxicants, but the extent to which PBDEs influence various domains of behavior in children is not fully understood. As such, we reviewed epidemiologic studies published to date to provide an overview of the current state of knowledge on PBDEs' potential role in behavioral development. We identified 19 epidemiologic studies reporting on associations of prenatal and childhood concentrations of PBDEs with behaviors assessed in children from 1 to 12years, including executive function, attention, externalizing and internalizing behaviors, adaptive skills, and social behaviors/Autism Spectrum Disorder (ASD)...
November 11, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29131611/synthesis-and-in-vitro-evaluation-of-monodisperse-amino-functional-polyester-dendrimers-with-rapid-degradability-and-antibacterial-properties
#5
Patrik Stenström, Erik Hjort, Yuning Zhang, Oliver C J Andrén, Simon Guette-Marquet, Marianne Schultzberg, Michael Malkoch
Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs and siRNA and simple functionalization in aqueous solutions. Dendrimers, a subclass of precision polymers, are monodisperse and exhibit a large and exact number of peripheral end groups in relation to their size and have shown promise in drug delivery, biomedical imaging and as anti-viral agents...
November 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29117435/overview-of-neurotoxicology
#6
Lucio G Costa
The nervous system has a central and primary function in the body, and its relevance and complexity make it a target for a large number of toxic substances. The most common forms of neurotoxicity are the death of neurons (neuronopathy), the degeneration of axons (axonopathy), damage to glial cells (e.g., myelinopathy), and interference with the axonal membrane or neurotransmission. Important neurotoxicants are found among pesticides, metals, solvents, natural substances, and industrial chemicals. Environmental chemicals may also contribute to the etiopathogenesis of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders...
November 8, 2017: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29112453/new-animal-free-concepts-and-test-methods-for-developmental-toxicity-and-peripheral-neurotoxicity
#7
Marcel Leist
The complex toxicological fields of repeat dose organ toxicity (RDT) and developmental and reproductive toxicity (DART) still require new concepts and approaches to achieve a fully animal-free safety assessment of chemicals. One novel approach is the generation of relevant human cell types from pluripotent stem cells, and the use of such cells for the establishment of phenotypic test methods. Due to their broad endpoints, such tests capture multiple types of toxicants, i.e. they are a readout for the activation of many adverse outcome pathways (AOPs)...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29107351/drinking-water-disinfection-by-products-during-pregnancy-and-child-neuropsychological-development-in-the-inma-spanish-cohort-study
#8
Cristina M Villanueva, Esther Gracia-Lavedan, Jordi Julvez, Loreto Santa-Marina, Nerea Lertxundi, Jesús Ibarluzea, Sabrina Llop, Ferran Ballester, Ana Fernández-Somoano, Adonina Tardón, Martine Vrijheid, Mònica Guxens, Jordi Sunyer
BACKGROUND: Disinfection by-products (DBPs) constitute a complex mixture of prevalent chemicals in drinking water and there is evidence of neurotoxicity for some of them. OBJECTIVES: We evaluated the association between estimates of DBP exposure during pregnancy and child neuropsychological outcomes at 1 and 4-5years of age. METHODS: We conducted a population-based mother-child cohort study in Spain with recruitment at first trimester of gestation (INMA Project, 2003-2008)...
January 2018: Environment International
https://www.readbyqxmd.com/read/29107229/seasonal-implications-on-toxicity-biomarkers-of-loricariichthys-anus-valenciennes-1835-from-a-subtropical-reservoir
#9
Aline Monique Blank do Amaral, Jeane de Lima Costa Gomes, Gustavo Henrique Weimer, Aline Teixeira Marins, Vania Lucia Loro, Renato Zanella
Cropping systems based on intensive land use and continuous application of agricultural chemicals inflict a threat to aquatic organisms since these substances will inevitably be carried in to water bodies where they can accumulate, particularly in lentic sites. Pesticides exposure in aquatic animals can cause changes that can be quantified through biomarkers. Thus, this study aimed to investigate the effects of season on oxidative stress and neurotoxicity biomarkers in Loricariichthys anus from a subtropical reservoir surrounded by agricultural areas in southern Brazil...
October 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/29105512/changes-in-the-metabolome-and-microrna-levels-in-biological-fluids-might-represent-biomarkers-of-neurotoxicity-a-trimethyltin-study
#10
Syed Z Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M Lantz, Sumit Sarkar, James Raymick, Bonnie Robinson, Joseph P Hanig, David Herr, Denise MacMillan, Aaron Smith, Serguei Liachenko, Sherry Ferguson, James O'Callaghan, Diane Miller, Christopher Somps, Ingrid D Pardo, William Slikker, Jennifer B Pierson, Ruth Roberts, Binsheng Gong, Weida Tong, Michael Aschner, Mary J Kallman, David Calligaro, Merle G Paule
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29104222/practical-synthesis-of-chalcone-derivatives-and-their-biological-activities
#11
Jae-Chul Jung, Yongnam Lee, Dongguk Min, Mankil Jung, Seikwan Oh
Practical synthesis and biological activities of 4-hydroxy-3-methoxy-2-propene derivatives are described. The novel chalcone derivatives were prepared by acid catalysed one-step condensation of 1,3- or 1,4-diacetylbenzene and 1,3,5-triacetylbenzene with 4-hydroxy-3-methoxybenzaldehyde. They were then evaluated for free radical scavenging activity, suppression of lipopolysaccharides (LPS)-induced NO generation, and anti-excitotoxicity in vitro. It was found that all compounds showed good effects for 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, LPS-induced NO generation, and anti-neurotoxicity...
November 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29098534/impairment-of-astrocytic-glutaminolysis-in-glutaric-aciduria-type-i
#12
Shoko Komatsuzaki, Raga Deepthi Ediga, Jürgen G Okun, Stefan Kölker, Sven W Sauer
Glutaric aciduria type I is a rare, autosomal recessive, inherited defect of glutaryl-CoA dehydrogenase. Deficiency of this protein in L-lysine degradation leads to the characteristic accumulation of nontoxic glutarylcarnitine and neurotoxic glutaric acid (GA), glutaryl-CoA, and 3-hydroxyglutaric acid. Untreated patients develop bilateral lesions of basal ganglia resulting in a complex movement disorder with predominant dystonia in infancy and early childhood. The current pathomechanistic concept strongly focuses on imbalanced neuronal energy metabolism due to accumulating metabolites, whereas little is known about the pathomechanistic role of astrocytes, which are thought to be in constant metabolic crosstalk with neurons...
November 2, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29096375/solid-lipid-nanoparticles-for-delivery-of-andrographolide-across-the-blood-brain-barrier-in-vitro-and-in-vivo-evaluation
#13
Giulia Graverini, Vieri Piazzini, Elisa Landucci, Daniela Pantano, Pamela Nardiello, Fiorella Casamenti, Domenico E Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi
Andrographolide is a major diterpenoid of Andrographis paniculata and possesses several biological activities, including protection against oxidative stress mediated neurotoxicity, inflammation-mediated neurodegeneration, and cerebral ischemia. However, this molecule shows low bioavailability, poor water solubility, and high chemical and metabolic instability. The present study reports preparation of solid lipid nanoparticles (SLN) to deliver andrographolide (AG) into the brain. SLN were prepared using Compritol 888 ATO as solid lipid and Brij 78 as surfactant and applying emulsion/evaporation/solidifying method as preparative procedure...
October 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29093363/prenatal-exposure-to-1-bromopropane-causes-delayed-adverse-effects-on-hippocampal-neuronal-excitability-in-the-ca1-subfield-of-rat-offspring
#14
Yukiko Fueta, Toru Ishidao, Susumu Ueno, Yasuhiro Yoshida, Yasunari Kanda, Hajime Hori
OBJECTIVES: Neurotoxicity of 1-bromopropane (1-BP) has been reported in occupational exposure, but whether the chemical exerts developmental neurotoxicity is unknown. We studied the effects of prenatal 1-BP exposure on neuronal excitability in rat offspring. METHODS: We exposed dams to 1-BP (700 ppm, 6 h a day for 20 days) and examined hippocampal slices obtained from the male offspring at 2, 5, 8, and 13 weeks of age. We measured the stimulation/response (S/R) relationship and paired-pulse ratios (PPRs) of the population spike (PS) at the interpulse intervals (IPIs) of 5 and 10 ms in the CA1 subfield...
November 1, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29092802/the-effects-of-mesna-on-the-facial-nerve-an-experimental-animal-study
#15
Deniz Baklacı, Rauf Oğuzhan Kum, Sezer Kulaçoğlu, Yavuz Fuat Yılmaz, Müge Özcan
OBJECTIVE: MESNA (Sodium-2-mercaptoethanesulfonate) is a mucolytic substance that is used for chemically assisted tissue dissection in various surgical operations. The aim of this study was to address the issue of possible neurotoxicity from topical administration of MESNA solution on the facial nerve. We used different concentrations of MESNA solution and evaluated their effects on facial nerve by histopathological and functional analysis. MATERIALS AND METHODS: These groups were the saline administered group (control) (3 rats, 6 facial nerves), the 25% MESNA solution group (3 rats, 6 facial nerves), and the 100% MESNA solution group (3 rats, 6 facial nerves)...
November 2, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29080611/annona-muricata-is-the-natural-therapy-to-most-disease-conditions-including-cancer-growing-in-our-backyard-a-systematic-review-of-its-research-history-and-future-prospects
#16
REVIEW
Yahaya Gavamukulya, Fred Wamunyokoli, Hany A El-Shemy
Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many medicinal uses. This review focuses on the research history of its traditional uses, phytochemicals, pharmacological activities, toxicological aspects of the extracts and isolated compounds, as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and treatment. A. muricata extracts have been identified in tropical regions to traditionally treat diverse conditions ranging from fever to diabetes and cancer...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29046125/pretreatment-with-n-acetyl-cysteine-suppresses-chronic-reactive-astrogliosis-following-maternal-nanoparticle-exposure-during-gestational-period
#17
Atsuto Onoda, Ken Takeda, Masakazu Umezawa
Early pregnant employees are potentially and unintendedly exposed to industrial chemicals including nanoparticles. Developmental toxicity of nanoparticle exposure has been concerned because exposure to fine particle including carbon black nanoparticle (CB-NP) during the brain developmental stage enhances the risk of brain disorders. Maternal CB-NP exposure dose-dependently induces astrogliosis, which is an abnormal increase in the reactive astrocytes with glial fibrillary acidic protein (GFAP) and aquaporin-4 overexpression due to the destruction of nearby neurons and blood vessels...
October 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29032222/molecular-mechanisms-of-nickel-induced-neurotoxicity-and-chemoprevention
#18
REVIEW
Xin Song, Samuel Selorm Fiati Kenston, Lu Kong, Jinshun Zhao
Nickel (Ni) is widely used in many industrial sectors such as alloy, welding, printing inks, electrical and electronics industries. Excessive environmental or occupational exposure to Ni may result in tumor, contact dermatitis, as well as damages to the nervous system. In recent years, more and more research has demonstrated that Ni induced nerve damages are related to mitochondrial dysfunction. In this paper, we try to characterize Ni induced neurotoxicity as well as the underlying mechanisms, and how to find new drugs for chemoprevention, by reviewing chemicals with neuroprotective effects on Ni induced neurotoxicity...
October 12, 2017: Toxicology
https://www.readbyqxmd.com/read/29020013/in-utero-and-lactational-exposure-to-low-doses-of-the-pyrethroid-insecticide-cypermethrin-leads-to-neurodevelopmental-defects-in-male-mice-an-ethological-and-transcriptomic-study
#19
Anthony Laugeray, Ameziane Herzine, Olivier Perche, Olivier Richard, Céline Montecot-Dubourg, Arnaud Menuet, Séverine Mazaud-Guittot, Laurianne Lesné, Bernard Jegou, Stéphane Mortaud
Accumulating evidence suggests that developmental exposure to environmental chemicals may modify the course of brain development, ultimately leading to neuropsychiatric / neurodegenerative disorders later in life. In the present study, we assessed the impact of one of the most frequently used pesticides in both residential and agricultural applications - the synthetic pyrethroid cypermethrin (CYP) - on developmental neurotoxicity (DNT). Female mice were perinatally exposed to low doses of CYP (5 and 20 mg/kg body weight) from gestation to postnatal day 15...
2017: PloS One
https://www.readbyqxmd.com/read/28993860/lanthanum-damages-learning-and-memory-and-suppresses-astrocyte-neuron-lactate-shuttle-in-rat-hippocampus
#20
Cuihong Jin, Liang Gao, Yingqi Li, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Yuan Cai
Rare-earth elements (REEs) are applied in various fields by virtue of their superior physical and chemical properties. Surveys have reported that REEs can impair learning and memory in children and induce neurobehavioral abnormalities in animals. However, the mechanism underlying this neurotoxicity is still unclear. Lanthanum (La) is often chosen to study the effects of REEs. Here, we investigated the role of astrocyte-neuron lactate shuttle (ANLS) in spatial learning and memory impairment induced by LaCl3 in hippocampus, an important spatial memory-related brain region...
December 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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