keyword
MENU ▼
Read by QxMD icon Read
search

chemical neurotoxicity

keyword
https://www.readbyqxmd.com/read/28913719/green-garden-snail-cantareus-apertus-as-biomonitor-and-sentinel-for-integrative-metal-pollution-assessment-in-roadside-soils
#1
Anwar Mleiki, Ionan Marigómez, Najoua Trigui El Menif
The present investigation was conceived to study, in a small scale field study, the potential of the green garden snail, Cantareus apertus, as biomonitor and sentinel for integrative metal pollution assessment in soils. For this purpose, we investigated the association between the trace metal (Cd, Pb, As, Fe, Cr, Cu, Ni, and Zn) concentrations in soil, plants (Trifolium repens), and C. apertus depending on the distance (20, 150, and 700 m) from a main roadside in Tunisia as well as between metal concentrations and biomarkers of oxidative stress, oxidative damage, and neurotoxicity in C...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28905488/genetically-engineering-better-fungal-biopesticides
#2
REVIEW
Brian Lovett, Raymond John St Leger
Microbial insect pathogens offer an alternative means of pest control with potential to wean our heavy reliance on chemical pesticides. Insect pathogenic fungi play an important natural role in controlling disease vectors and agricultural pests. Most commercial products employ Ascomycetes in the genera Metarhizium and Beauveria. However, their utilization has been limited by inconsistent field results due to sensitivity to abiotic stresses and naturally low virulence. Other naturally occurring biocontrol agents also face these hurdles to successful application, but the availability of complete genomes and recombinant DNA technologies have facilitated design of multiple fungal pathogens with enhanced virulence and stress resistance...
September 14, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28902461/behavioral-responses-of-pest-mole-crickets-neoscapteriscus-spp-orthoptera-gryllotalpidae-to-selected-insecticides
#3
Olga S Kostromytska, Michael E Scharf, Eileen A Buss
BACKGROUND: Mole crickets (Neoscapteriscus spp.) consume turfgrasses and pasture grasses and uproot plants by their tunneling, which decreases turf aesthetics and decreases forage quantity and quality. Insecticides are frequently used to prevent damage. In typical field trials, damage symptoms, not percent of mortality or achieved level of control, are used to assess treatment efficacy. Here however, we evaluated the direct effect of key insecticides on Neoscapteriscus mole cricket behavior...
September 13, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28900807/ecotoxicological-impact-assessment-of-the-brine-discharges-from-a-desalination-plant-in-the-marine-waters-of-the-algerian-west-coast-using-a-multibiomarker-approach-in-a-limpet-patella-rustica
#4
Meriem Benaissa, Omar Rouane-Hacene, Zitouni Boutiba, Marielle E Guibbolini-Sabatier, Christine Risso-De Faverney
The aim of our study is to evaluate the impact of Bousfer desalination plant brine discharges on the Algerian west coast, on a natural population of the marine gastropod mollusc Patella rustica. The effects of a chronic exposure to such discharges are complex to understand due to the combined effects of environmental physico-chemical parameters (e.g., high salinity) and different pollutants that can modulate the physiological responses of this species to stress. In this context, we assessed the biological effects in a marine species P...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28890316/iron-biochemistry-is-correlated-with-amyloid-plaque-morphology-in-an-established-mouse-model-of-alzheimer-s-disease
#5
Neil D Telling, James Everett, Joanna F Collingwood, Jon Dobson, Gerrit van der Laan, Joseph J Gallagher, Jian Wang, Adam P Hitchcock
A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aβ) fibrils in the brain. Nevertheless, the links between Aβ and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from aggregation of the Aβ1-42 peptide can in part be explained by metal ion binding interactions. Using advanced X-ray microscopy techniques at sub-micron resolution, we investigated relationships between iron biochemistry and AD pathology in intact cortex from an established mouse model over-producing Aβ...
August 24, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28889263/chemical-speciation-of-selenium-and-mercury-as-determinant-of-their-neurotoxicity
#6
C S Oliveira, B C Piccoli, M Aschner, J B T Rocha
The antagonism of mercury toxicity by selenium has been well documented. Mercury is a toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or brain) of mercury vary depending on its chemical forms (inorganic or organic). Selenium is a semimetal essential to mammalian life as part of the amino acid selenocysteine, which is required to the synthesis of the selenoproteins. This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se(-2) or HSe(-)) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg(2+) and MeHg)...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28886427/tolerance-to-dichloroacetonitrile-induced-neurotoxicity-in-streptozotocin-induced-diabetic-rats
#7
Fang Li, Ying Dong, Haijun Shen, Rongzhu Lu, Siqi Yin, Weihong Tian, Suhua Wang, Guangwei Xing
Diabetes mellitus has potential to alter the toxicity of hazardous chemicals. Dichloroacetonitrile (DCAN) is one of high-risk nitrogenous disinfection by-products. This study evaluated the neurotoxicity of DCAN (11, 44 and 88mg/kg) in normoglycaemic and streptozotocin (STZ)-induced diabetic rats via orally for 28days. STZ diabetes prolonged the median survival time and total lethal time after DCAN (88mg/kg) exposure when compared with that observed in normoglycaemic rats. DCAN altered motor activity and induced anxiety behaviour in normoglycaemic rats; but it did not exaggerate behavioural changes in STZ diabetic rats...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28880749/exposure-to-decabromodiphenyl-ether-bde-209-produces-mitochondrial-dysfunction-in-rat-liver-and-cell-death
#8
Lilian C Pereira, Alecsandra O Souza, Maria J Tasso, Alana M C Oliveira, Filipe V Duarte, Carlos M Palmeira, Daniel J Dorta
Polybrominated diphenyl ethers (PBDE) are ubiquitous environmental pollutants. Exposure to these chemicals has been associated with developmental neurotoxicity, endocrine dysfunctions, reproductive disorders, and hepatotoxicity. The widespread use of PBDE as flame retardants has culminated in daily exposure of humans and wildlife to these contaminants and resulted in their banned use. Thus assessment of the potential effects of each PBDE congener on living organisms has become cause for concern. The aim of this study was to (1) examine the effects of decabromodiphenyl ether (BDE)-209 on different functions of HepG2 cells and (2) investigate whether this congener is involved in mitochondrial toxicity...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28875469/a-panel-of-autoantibodies-against-neural-proteins-as-peripheral-biomarker-for-pesticide-induced-neurotoxicity
#9
Heba Allah Abd El Rahman, Mohamed Salama, Seham A Gad El-Hak, Mona A El-Harouny, Passent ElKafrawy, Mohamed B Abou-Donia
In the present study, we screened the sera of subjects chronically exposed to mixtures of pesticides (composed mainly of organophosphorus compounds (OPs) and others) and developed neurological symptoms for the presence of autoantibodies against cytoskeletal neural proteins. OPs have a well-characterized clinical profile resulting from acute cholinergic crisis. However, some of these compounds cause neuronal degeneration and demyelination known as organophosphorus compound-induced delayed neurotoxicity (OPIDN) and/or organophosphorus compound-induced chronic neurotoxicity (OPICN)...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28869331/synthesis-and-structure-activity-relationships-of-carbohydrazides-and-1-3-4-oxadiazole-derivatives-bearing-imidazolidine-moiety-against-the-yellow-fever-and-dengue-vector-aedes-aegypti
#10
Fatih Tok, Bedia Kocyigit-Kaymakcioglu, Nurhayat Tabanca, Alden S Estep, Aaron D Gross, Werner J Geldenhuys, James J Becnel, Jeffrey R Bloomquist
BACKGROUND: 1,3,4-oxadiazole and imidazolidine rings are important heterocyclic compounds exhibiting a variety of biological activities. In this study, novel compounds with oxadiazole and imidazolidine rings were synthesized from 3-(methylsulfonyl)-2-oxoimidazolidine-1-carbonyl chloride and screened for insecticidal activities. The proposed structures of the 17 synthesized compounds were confirmed using elemental analysis, IR, (1) H-NMR, and mass spectroscopy. RESULTS: None of the compounds showed larvicidal activity at the tested concentrations against 1(st) instar Aedes aegypti larvae...
September 4, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28852095/amyloid-precursor-protein-drives-down-regulation-of-mitochondrial-oxidative-phosphorylation-independent-of-amyloid-beta
#11
M Isabel G Lopez Sanchez, Hayley S Waugh, Andrew Tsatsanis, Bruce X Wong, Jonathan G Crowston, James A Duce, Ian A Trounce
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer's disease are associated with mutations in APP that increase toxic amyloidogenic cleavage of APP and produce amyloid beta (Aβ) at the expense of sAPPα and other non-amyloidogenic fragments. Although mitochondrial dysfunction has become an established hallmark of neurotoxicity, the link between Aβ and mitochondrial function is unclear...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851615/assessing-the-role-of-dopamine-in-the-differential-neurotoxicity-patterns-of-methamphetamine-mephedrone-methcathinone-and-4-methylmethamphetamine
#12
REVIEW
John H Anneken, Mariana Angoa-Perez, Girish C Sati, David Crich, Donald M Kuhn
Methamphetamine and mephedrone are designer drugs with high abuse liability and they share extensive similarities in their chemical structures and neuropharmacological effects. However, these drugs differ in one significant regard: methamphetamine elicits dopamine neurotoxicity and mephedrone does not. From a structural perspective, mephedrone has a β-keto group and a 4-methyl ring addition, both of which are lacking in methamphetamine. Our previous studies found that methcathinone, which contains only the β-keto substituent, is neurotoxic, while 4-methylmethamphetamine, which contains only the 4-methyl ring substituent, elicits minimal neurotoxicity...
August 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28845027/dibutyl-phthalate-rather-than-monobutyl-phthalate-facilitates-contact-hypersensitivity-to-fluorescein-isothiocyanate-in-a-mouse-model
#13
Kohta Kurohane, Kota Sekiguchi, Erina Ogawa, Masato Tsutsumi, Yasuyuki Imai
Dibutyl phthalate (DBP) is a plasticizer used for many consumer products including cosmetics. Potential health concerns regarding DBP include reproductive and developmental toxicity, endocrine disruption and neurotoxicity. DBP is a high priority chemical as to reduction of exposure of children to it. Through reproductive toxicity studies, monobutyl phthalate (MBP) has been proposed to be the active metabolite derived from DBP. We previously demonstrated that DBP activates transient receptor potential ankyrin 1 (TRPA1) cation channels expressed on sensory neurons...
August 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28844784/dieldrin-induced-neurotoxicity-involves-impaired-mitochondrial-bioenergetics-and-an-endoplasmic-reticulum-stress-response-in-rat-dopaminergic-cells
#14
Jordan T Schmidt, Anna Rushin, Jonna Boyda, Christopher Laurence Souders, Christopher J Martyniuk
Mitochondria are sensitive targets of environmental chemicals. Dieldrin (DLD) is an organochlorine pesticide that remains a human health concern due to high lipid bioaccumulation, and it has been epidemiologically associated to an increased risk for Parkinson's disease (PD). As mitochondrial dysfunction is involved in the etiology of PD, this study aimed to determine whether DLD impaired mitochondrial bioenergetics in dopaminergic cells. Rat immortalized dopaminergic N27 cells were treated for 24 or 48h with one dose of either a solvent control, 2...
August 24, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28841302/molecular-mechanism-for-the-epigallocatechin-gallate-induced-toxic-to-nontoxic-remodeling-of-a%C3%AE-oligomers
#15
Rashik Ahmed, Bryan VanSchouwen, Naeimeh Jafari, Xiaodan Ni, Joaquin Ortega, Giuseppe Melacini
(-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer's disease β-amyloid peptide (Aβ) by remodeling seeding-competent Aβ oligomers into off-pathway seeding-incompetent Aβ assemblies. However, the mechanism of EGCG-induced remodeling is not fully understood. Here we combine (15)N and (1)H dark-state exchange saturation transfer (DEST), relaxation, and chemical shift projection NMR analyses with fluorescence, dynamic light scattering, and electron microscopy to elucidate how EGCG remodels Aβ oligomers...
August 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28836188/heme-oxygenase-1-inducing-activity-of-4-methoxydalbergione-and-4-hydroxy-4-methoxydalbergione-from-dalbergia-odorifera-and-their-anti-inflammatory-and-cytoprotective-effects-in-murine-hippocampal-and-bv2-microglial-cell-line-and-primary-rat-microglial-cells
#16
Dong-Cheol Kim, Dong-Sung Lee, Wonmin Ko, Kwan-Woo Kim, Hye Jin Kim, Chi-Su Yoon, Hyuncheol Oh, Youn-Chul Kim
Dalbergia odorifera T. Chen (Leguminosae) grows in Central and South America, Africa, Madagascar, and Southern Asia. D. odorifera possesses many useful pharmacological properties, such as antioxidative and anti-inflammatory activities in various cell types. 4-Methoxydalbergione (MTD) and 4'-hydroxy-4-methoxydalbergione (HMTD) were isolated from the EtOH extract of D. odorifera by several chromatography methods. The chemical structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrum (MS)...
August 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28821675/synergistic-toxicity-of-polyglutamine-expanded-tbp-in-glia-and-neuronal-cells-therapeutic-implications-for-sca17
#17
Yang Yang, Su Yang, Jifeng Guo, Yiting Cui, Baisha Tang, Xiao-Jiang Li, Shihua Li
Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. Although previous studies have demonstrated that expression of polyQ-expanded proteins in glial cells can cause neuronal injury via non-cell-autonomous mechanisms, these studies investigated animal models that overexpress transgenic mutant proteins. Since glial cells are particularly reactive to overexpressed mutant proteins, it is important to investigate the in vivo role of glial dysfunction in neurodegeneration when mutant polyQ proteins are endogenously expressed...
August 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28818579/developing-integrated-pbpk-pd-coupled-mechanistic-pathway-model-mirna-bdnf-an-approach-towards-system-toxicology
#18
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model. This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both - the chemicals and - biomolecules, help us to understand the dynamic and steady-state behaviors of molecular pathways under perturbed condition...
August 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28797629/molecular-and-morphological-survey-of-saxitoxin-producing-cyanobacterium-dolichospermum-circinale-anabaena-circinalis-isolated-from-geographically-distinct-regions-of-australia
#19
Joao P A Pereyra, Paul M D'Agostino, Rabia Mazmouz, Jason N Woodhouse, Russell Pickford, Ian Jameson, Brett A Neilan
The cyanobacterium Dolichospermum circinale (formerly Anabaena circinalis) is responsible for neurotoxic saxitoxin-producing blooms in Australia. Previous studies have reported distinct isolates of toxic D. circinale producing different saxitoxin analogues at varying amounts, but the mechanisms responsible remain poorly understood. To assess the characteristics that may be responsible for this variance, a morphological, molecular and chemical survey of 28 Anabaena isolates was conducted. Morphological characteristics, presence or absence of saxitoxin biosynthetic genes and toxin amount and profile were assessed...
August 7, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28792214/aggregation-and-fibril-structure-of-a%C3%AE-m01-42-and-a%C3%AE-1-42
#20
Robert Silvers, Michael T Colvin, Kendra K Frederick, Angela C Jacavone, Susan Lindquist, Sara Linse, Robert G Griffin
A mechanistic understanding of Aβ aggregation and high-resolution structures of Aβ fibrils and oligomers are vital to elucidating relevant details of neurodegeneration in Alzheimer's disease, which will facilitate the rational design of diagnostic and therapeutic protocols. The most detailed and reproducible insights into structure and kinetics have been achieved using Aβ peptides produced by recombinant expression, which results in an additional methionine at the N-terminus. While the length of the C-terminus is well established to have a profound impact on the peptide's aggregation propensity, structure, and neurotoxicity, the impact of the N-terminal methionine on the aggregation pathways and structure is unclear...
August 30, 2017: Biochemistry
keyword
keyword
76500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"