keyword
MENU ▼
Read by QxMD icon Read
search

chemical neurotoxicity

keyword
https://www.readbyqxmd.com/read/28326551/cyclic-imine-toxins-from-dinoflagellates-a-growing-family-of-potent-antagonists-of-the-nicotinic-acetylcholine-receptors
#1
REVIEW
Jordi Molgó, Pascale Marchot, Rómulo Aráoz, Evelyne Benoit, Bogdan I Iorga, Armen Zakarian, Palmer Taylor, Yves Bourne, Denis Servent
We present an overview of the toxicological profile of the fast-acting, lipophilic macrocyclic imine toxins, an emerging family of organic compounds associated with algal blooms, shellfish contamination and neurotoxicity. Worldwide, shellfish contamination incidents are expanding; therefore, the significance of these toxins for the shellfish food industry deserves further study. Emphasis is directed to the dinoflagellate species involved in their production, their chemical structures, and their specific mode of interaction with their principal natural molecular targets, the nicotinic acetylcholine receptors, or with the soluble acetylcholine-binding protein, used as a surrogate receptor model...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28295317/applications-of-natural-zeolites-on-agriculture-and-food-production
#2
REVIEW
Nazife Eroglu, Mevlut Emekci, Christos Athanassiou
Zeolites are crystalline hydrated aluminosilicates with remarkable physical and chemical properties including losing and receiving water in a reverse way, adsorbing molecules that act as molecular sieves, and replacing their constituent cations without structural change. Commercial production of natural zeolites has accelerated during last fifty years. The Structure Commission of the International Zeolite Association recorded more than 200 zeolites which currently include more than 40 naturally occurring zeolites...
March 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28294544/identification-of-acetylcholinesterase-inhibitors-using-homogenous-cell-based-assays-in-quantitative-high-throughput-screening-platforms
#3
Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F Santillo, Menghang Xia
Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. Inhibition of AChE activity can serve as a therapeutic mechanism, but also cause adverse health effects and neurotoxicity. In order to efficiently identify AChE inhibitors from large compound libraries, homogenous cell-based assays in high-throughput screening platforms are needed. In this study, a fluorescent method using Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine) and the Ellman absorbance method were both developed in a homogenous format using a human neuroblastoma cell line (SH-SY5Y)...
March 14, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28270159/a-path-analysis-of-multiple-neurotoxic-chemicals-and-cognitive-functioning-in-older-us-adults-nhanes-1999-2002
#4
Jennifer Przybyla, E Andres Houseman, Ellen Smit, Molly L Kile
BACKGROUND: Polychlorinated biphenyls (PCBs) and metals (lead and cadmium) are neurotoxic and affect neurobehavioral performance. Yet little is known about the association between exposure to multiple neurotoxic compounds and cognitive functioning in older adults. METHODS: Using data from two consecutive cycles of the National Health and Nutrition and Examination Survey (1999-2002), path analysis was used to simultaneously evaluate the association between whole blood concentrations of 14 neurotoxic compounds and cognitive functioning measured by the Digit Symbol Coding Test of the Weschler Adult Intelligence Scale, 3(rd) Edition in participants 60-84 years of age (N = 498)...
March 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28267745/disturbed-sensorimotor-and-electrophysiological-patterns-in-lead-intoxicated-rats-during-development-are-restored-by-curcumin-i
#5
Hind Benammi, Hasna Erazi, Omar El Hiba, Laurent Vinay, Hélène Bras, Jean-Charles Viemari, Halima Gamrani
Lead poisoning is one of the most significant health problem of environmental origin. It is known to cause different damages in the central and peripheral nervous system which could be represented by several neurophysiological and behavioral symptoms. In this study we firstly investigated the effect of lead prenatal exposure in rats to (3g/L), from neonatal to young age, on the motor/sensory performances, excitability of the spinal cord and gaits during development. Then we evaluated neuroprotective effects of curcumin I (Cur I) against lead neurotoxicity, by means of grasping and cliff avoidance tests to reveal the impairment of the sensorimotor functions in neonatal rats exposed prenatally to lead...
2017: PloS One
https://www.readbyqxmd.com/read/28263526/bioindicators-of-wastewater-ecotoxicity
#6
Gabriela Jirova, Zdenka Wittlingerova, Magdalena Zimova, Alena Vlkova, Martina Wittlerova, Marketa Dvorakova, Dagmar Jirova
Wastewater, especially containing hospital effluents, exhibits high chemical complexity and specificity since it includes various chemicals, biocides, pharmaceuticals, surfactants, radionuclides, disinfectants and pathogens. Biological tests provide true evidence of the wastewater quality and unlike chemical analytical tests show comprehensive pollution effects on the environment and human health. Normalized conventional bioassays are not sensitive enough for ecotoxicological evaluation of wastewater and there is a great need for the development of suitable sensitive bioassays in order to characterize properly the residual toxicity of treated effluents...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28242563/pesticides-polychlorinated-biphenyls-and-polycyclic-aromatic-hydrocarbons-in-cerebrospinal-fluid-of-amyotrophic-lateral-sclerosis-patients-a-case-control-study
#7
Marco Vinceti, Federica Violi, Manolis Tzatzarakis, Jessica Mandrioli, Carlotta Malagoli, Elizabeth E Hatch, Nicola Fini, Antonio Fasano, Valerii N Rakitskii, Olga-Ioanna Kalantzi, Aristides Tsatsakis
Neurotoxic chemicals including several pesticides have been suggested to play a role in the etiology of amyotrophic lateral sclerosis (ALS). We investigated the relation between organochlorine pesticides and their metabolites (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in the etiology of sporadic ALS, determining for the first time their levels in cerebrospinal fluid as indicator of antecedent exposure. We recruited 38 ALS patients and 38 controls referred to an Italian clinical center for ALS care, who underwent a lumbar puncture for diagnostic purposes between 1994-2013, and had 1mL of cerebrospinal fluid available for the determination of OCPs, PCBs and PAHs...
February 24, 2017: Environmental Research
https://www.readbyqxmd.com/read/28237517/characterization-of-manganese-bearing-particles-in-the-vicinities-of-a-manganese-alloy-plant
#8
Ana Hernández-Pellón, Ignacio Fernández-Olmo, Frédéric Ledoux, Lucie Courcot, Dominique Courcot
Numerous studies have associated air manganese (Mn) exposure with negative health effects, primarily neurotoxic disorders. Despite there is not a specific European regulation, institutions such as the World Health Organization (WHO) have proposed an annual average guideline value of 150 ng/m(3). Bioaccessibility and toxicity mechanisms of Mn remain unclear, however it is generally agreed that adverse health effects are strongly linked to particle size and morphology, chemical composition and oxidation state...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28237474/neuroprotective-activity-of-two-active-chemical-constituents-from-tinospora-hainanensis
#9
Dao-Rui Yu, Li-Ping Ji, Tao Wang, Xi-Nan Yi, Guo-Hui Yi, Tong He, Yong-Xiao Cao, En-Wu Long, Qi-Bing Liu
OBJECTIVE: To determine the chemical structure of the new compound and investigate the protective effects of Tinosporaic acid A and B towards in-vitro neuro. METHODS: The structures of two new compounds were established by analyzing its 1D and 2D NMR spectra as well as HRESIMS. Their neuroprotective effects with respect to the antioxidant properties were evaluated by radical scavenging tests and hydrogen peroxide-injured oxidative stress model in PC12 cell lines...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28214749/impairment-in-the-mesohippocampal-dopamine-circuit-following-exposure-to-the-brominated-flame-retardant-hbcdd
#10
Camille Pham-Lake, Elizabeth B Aronoff, Chad R Camp, Aimee Vester, Sam J Peters, W Michael Caudle
Many chemicals have been used to increase the safety of consumer products by reducing their flammability and risk for ignition. Recent focus on brominated flame retardants, such as polybrominated diphenyl ethers (PBDEs) has shown them to contribute to neurobehavioral deficits in children, including learning and memory. As the manufacture and use of PBDEs have been reduced, replacement chemicals, such as hexabromocyclododecane (HBCDD) have been substituted. Our current study evaluated the neurotoxicity of HBCDD, concentrating on dopaminergic innervation to the hippocampus...
March 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28210952/two-dechlorinated-chlordecone-derivatives-formed-by-in-situ-chemical-reduction-are-devoid-of-genotoxicity-and-mutagenicity-and-have-lower-proangiogenic-properties-compared-to-the-parent-compound
#11
Samuel Legeay, Pierre-André Billat, Nicolas Clere, Fabrice Nesslany, Sébastien Bristeau, Sébastien Faure, Christophe Mouvet
Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by CLD. In the present study, the objectives were (i) to evaluate the genotoxicity and the mutagenicity of two CLD metabolites formed by ISCR, CLD-5a-hydro, or CLD-5-hydro (5a- or 5- according to CAS nomenclature; CLD-1Cl) and tri-hydroCLD (CLD-3Cl), and (ii) to explore the angiogenic properties of these molecules...
February 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28204887/determination-of-monoamine-neurotransmitters-in-zebrafish-danio-rerio-by-gas-chromatography-coupled-to-mass-spectrometry-with-a-two-step-derivatization
#12
Alvaro Aragon, Jessica Legradi, Ana Ballesteros-Gómez, Juliette Legler, Martin van Velzen, Jacob de Boer, Pim Leonards
A sensitive analytical method for the determination of monoamine neurotransmitters (MNTs) in zebrafish larvae was developed using gas chromatography coupled to mass spectrometry. Six MNTs were selected as target compounds for neurotoxicity testing. MNTs underwent a two-step derivatization with hexamethyldisilazane (HDMS) for O-silylation followed by N-methyl-bis-heptafluorobutyramide (MBHFBA) for N-perfluoroacylation. Derivatization conditions were optimized by an experimental design approach. Method validation showed linear calibration curves (r (2) > 0...
February 15, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28185030/detrimental-effect-of-deltamethrin-on-the-central-nervous-system-synganglion-of-rhipicephalus-sanguineus-ticks
#13
Melissa Carolina Pereira, Ana Elisa Gasparotto, Juliana Paneczko Jurgilas, Letícia Aurora Coelho da Silva, Mayara Cristina Pereira, Samantha Santos Silveira, Thays Neigri Silva, André Arnosti, Maria Izabel Camargo-Mathias
Ticks are ectoparasites of medical and veterinary importance, which transmit many infectious agents, causing significant damage to the hosts. The "dog tick" Rhipicephalus sanguineus is responsible for transmitting several pathogens to dogs, motivating researchers to investigate efficient and sustainable control methods. Currently, chemical acaricides currently in use target the central nervous system (synganglion), which is responsible for controlling all the systemic functions of the ticks. Here, the neurotoxic potential of deltamethrin on the synganglion of unfed R...
February 9, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28183673/attenuation-of-the-in-vitro-neurotoxicity-of-316l-ss-by-graphene-oxide-surface-coating
#14
Nishat Tasnim, Alok Kumar, Binata Joddar
A persistent theme in biomaterials research comprises of surface engineering and modification of bare metallic substrates for improved cellular response and biocompatibility. Graphene Oxide (GO), a derivative of graphene, has outstanding chemical and mechanical properties; its large surface to volume ratio, ease of surface modification and processing make GO an attractive coating material. GO-coatings have been extensively studied as biosensors. Further owing to its surface nano-architecture, GO-coated surfaces promote cell adhesion and growth, making it suitable for tissue engineering applications...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28179120/novel-therapeutic-approaches-for-disease-modification-of-epileptogenesis-for-curing-epilepsy
#15
REVIEW
Bryan L Clossen, Doodipala Samba Reddy
This article describes the recent advances in epileptogenesis and novel therapeutic approaches for the prevention of epilepsy, with a special emphasis on the pharmacological basis of disease-modification of epileptogenesis for curing epilepsy. Here we assess animal studies and human clinical trials of epilepsy spanning 1982-2016. Epilepsy arises from a number of neuronal factors that trigger epileptogenesis, which is the process by which a brain shifts from a normal physiologic state to an epileptic condition...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28174116/comparative-study-of-human-neuronal-and-glial-cell-sensitivity-for-in%C3%A2-vitro-neurogenotoxicity-testing
#16
Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Eduardo Pásaro, Vanessa Valdiglesias
Cell cultures from neuronal and glial origin have proven to be powerful tools for elucidating cellular and molecular mechanisms of nervous system development and physiology, and as neurotoxicity models to evaluate in vitro the possible effects of chemicals. But cellular heterogeneity of nervous system is considerable and these cells have been shown to respond diversely to neurotoxic insults, leading to disparate results from different studies. To shed more light on suitability of cellular models of nervous origin for neurotoxicity screening, the objective of this study was to compare the sensitivity to genetic damage induction of two nervous cell lines...
February 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28174047/gammarus-fossarum-as-a-sensitive-tool-to-reveal-residual-toxicity-of-treated-wastewater-effluents
#17
Adriana Wigh, Olivier Geffard, Khedidja Abbaci, Adeline Francois, Patrice Noury, Alexandre Bergé, Emmanuelle Vulliet, Bruno Domenjoud, Adriana Gonzalez-Ospina, Sylvie Bony, Alain Devaux
Wastewater treatment plants (WWTPs) are one of the main sources of freshwater pollution eventually resulting in adverse effects in aquatic organisms. Treated effluents can contain many micropollutants at concentrations often below the limit of chemical quantification. On a regulatory basis, WWTP effluents have to be non-toxic to the aquatic environment, wherefore not only chemical abatement but also ecotoxicological evaluation through relevant bioassays is required. Standardized bioassays currently used are often not sensitive enough to reveal a residual toxicity in treated effluents...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28174041/occurrence-origin-and-toxicity-of-disinfection-byproducts-in-chlorinated-swimming-pools-an-overview
#18
REVIEW
Tarek Manasfi, Bruno Coulomb, Jean-Luc Boudenne
Disinfection treatments are critical to conserve the microbiological quality of swimming pool water and to prevent water-borne infections. The formation of disinfection byproducts (DBPs) in swimming pools is an undesirable consequence resulting from reactions of disinfectants (e.g. chlorine) with organic and inorganic matter present in pool water, mainly brought by bathers. A considerable body of occurrence studies has identified several classes of DBPs in swimming pools with more than 100 compounds detected, mainly in chlorinated freshwater pools...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28163087/l-%C3%AE-n-methylamino-l-alanine-bmaa-nitrosation-generates-a-cytotoxic-dna-damaging-alkylating-agent-an-unexplored-mechanism-for-neurodegenerative-disease
#19
G Potjewyd, P J Day, S Shangula, G P Margison, A C Povey
BACKGROUND: L-β-N-methylamino-l-alanine (BMAA) is a non-proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC) on Guam. Given that natural amino acids can be N-nitrosated to form toxic alkylating agents and the structural similarity of BMAA to other amino acids, our hypothesis was that N-nitrosation of BMAA might result in a toxic alkylating agent, providing a novel mechanistic hypothesis for BMAA action...
February 3, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28160812/noise-and-neurotoxic-chemical-exposure-relationship-to-workplace-traumatic-injuries-a-review
#20
Cheryl Fairfield Estill, Carol H Rice, Thais Morata, Amit Bhattacharya
INTRODUCTION: More than 5,000 fatalities and eight million injuries occurred in the workplace in 2007 at a cost of $6 billion and $186 billion, respectively. Neurotoxic chemicals are known to affect central nervous system functions among workers, which include balance and hearing disorders. However, it is not known if there is an association between exposure to noise and solvents and acute injuries. METHOD: A thorough review was conducted of the literature on the relationship between noise or solvent exposures and hearing loss with various health outcomes...
February 2017: Journal of Safety Research
keyword
keyword
76500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"