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https://www.readbyqxmd.com/read/29241169/imaging-of-intracranial-gliomas
#1
Yuko Ono, Mikhail F Chernov, Yoshihiro Muragaki, Takashi Maruyama, Kayoko Abe, Hiroshi Iseki
Combined use of contemporary radiological modalities, particularly integration of structural, metabolic, and functional imaging, provides optimal multifaceted information for detailed characterization of intracranial gliomas. It allows differentiation of the tumor from non-neoplastic pathology, its non-invasive histopathological typing and grading, prediction of patient prognosis and clinical course of the disease, detailed planning of surgical resection or biopsy, critical postoperative assessment of the residual lesion, effective surveillance during follow-up with evaluation of effectiveness of the adjuvant therapy and timely identification of recurrence, and even insights into molecular signatures of the neoplasms...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29240905/coronary-autoregulation-and-assessment-of-stenosis-severity-without-pharmacological-vasodilation
#2
Guus A de Waard, Christopher M Cook, Niels van Royen, Justin E Davies
For identification of myocardial ischaemia by non-invasive imaging or invasive physiological assessment, administration of a vasodilating or positive inotropic agent is often considered indispensable to exhaust the cardiac compensation mechanisms. Indeed, microcirculatory dilatation is needed for assessment of myocardial perfusion or coronary blood flow. However, three different modalities exist that quantify myocardial ischaemia without recourse to pharmacological stress agents, using either myocardial contrast echocardiography, imaging of myocardial blood volume or invasive coronary pressure measurement with the instantaneous wave-free ratio (iFR)...
December 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29240862/-deep-heating-noninvasive-skin-tightening-devices-review-of-efectiveness-and-patient-satisfaction
#3
Suneel Chilukuri, Jason Lupton
<p>Non-surgical aesthetic devices intended for treatment of lax and loose skin have gained popularity due to their ability to non-invasively improve patient's aesthetic condition and its low side effect profle. This study is intended to review available peer reviewed literature about Ultherapy, ThermaCool, and Exilis Ultra 360 non-invasive skin tightening devices to compare their treatment effcacy and patient subjective satisfaction.</p> <p><em>J Drugs Dermatol. 2017;16(12):1262-1266...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240457/urinary-peptidomics-in-kidney-disease-and-drug-research
#4
Magdalena Krochmal, Joost P Schanstra, Harald Mischak
Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases...
December 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29239860/reference-intervals-for-the-evoked-tympanic-membrane-displacement-measurement-a-non-invasive-measure-of-intracranial-pressure
#5
Cherith M Campbell-Bell, Anthony A Birch, Dario Vignali, Diederik O Bulters, Robert J Marchbanks
OBJECTIVE Evoked tympanic membrane displacement (TMD) is a non-invasive technique for assessing intracranial pressure (ICP). The aim of this study was to define reference intervals (RIs) in the healthy population. Approach Measurements were made in 154 healthy adults. Results were quantified by Vm which is the most frequently described TMD measurement. Distributions were determined for sitting and supine posture. Differences between right and left ears were explored using a Wilcoxon signed-rank test...
December 14, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29239850/small-bowel-capsule-endoscopy-may-we-delegate-it-to-nurses
#6
Johann Dreanic, Maximilien Barret, Marion Dhooge, Marianne Gaudric, Sarah Leblanc, Vered Abitbol, Frederic Prat, Stanislas Chaussade, Romain Coriat
AIM: Small bowel capsule endoscopy (CE) is a non-invasive and validated technique allowing the visualization of the small intestine mucosa. It generated more than 40,000 images per examination and induced a long median time of medical reading that may exceed 1 hour. In a transfer of skills' program, the CE reading might be transferred to nurses. We herein evaluate and present a feasibility study of the CE to nurses. METHODS: Nurses experienced in endoscopy were trained for small bowel CE reading, selection and interpretation of pathological images...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29239844/selected-high-risk-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy-for-adjuvant-chemotherapy-a-multi-institutional-retrospective-study
#7
Masaomi Ikeda, Kazumasa Matsumoto, Takahiro Hirayama, Dai Koguchi, Yasukiyo Murakami, Daisuke Matsuda, Norihiko Okuno, Takuji Utsunomiya, Yoshinori Taoka, Akira Irie, Masatsugu Iwamura
BACKGROUND: No definitive evidence exists regarding use of adjuvant chemotherapy (AC) for high-risk cases after radical nephroureterectomy (RNU), and the benefit of AC remains controversial. The aims of this study were to evaluate the efficacy of AC in patients with upper tract urothelial carcinoma (UTUC) and to determine those who qualified for AC. PATIENTS AND METHODS: From 1990 to 2015, 449 patients with nonmetastatic UTUC underwent RNU at 6 Kitasato University-affiliated hospitals...
November 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29239827/factors-affecting-body-composition-in-preterm-infants-assessment-techniques-and-nutritional-interventions
#8
REVIEW
K Strydom, E Van Niekerk, M A Dhansay
Limited research has been conducted that elucidates the growth and body composition of preterm infants. It is known that these infants do not necessarily achieve extra-utero growth rates and body composition similar to those of their term counterparts. Preterm infants, who have difficulty in achieving these growth rates, could suffer from growth failure. These infants display an increased intra-abdominal adiposity and abnormal body composition when they achieve catch-up growth. These factors affect the quality of weight gain, as these infants are not only shorter and lighter than term infants, they also have more fat mass (FM) and less fat-free mass (FFM), resulting in a higher total fat percentage...
October 28, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29239819/lncrna-hoxd-as1-promotes-epithelial-ovarian-cancer-cells-proliferation-and-invasion-by-targeting-mir-133a-3p-and-activating-wnt-%C3%AE-catenin-signaling-pathway
#9
Ying Zhang, Yanbing Dun, Shumin Zhou, Xiang-Hua Huang
BACKGROUND: Long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) functions as a crucial regulator in the progression and development of tumors. The aim of this study is to unravel the underlying mechanisms of HOXD-AS1 on epithelial ovarian cancer (EOC). METHODS: 43 paired EOC tissues and adjacent non-tumor tissues were collected postoperatively from patients. QRT-PCR was used to explore HOXD-AS1 expression in both EOC tissues and cell lines. Cell proliferation and invasion were monitored by MTT assay and transwell invasion assay...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29239816/mir-9-5p-promotes-cell-growth-and-metastasis-in-non-small-cell-lung-cancer-through-the-repression-of-tgfbr2
#10
Gang Li, Fang Wu, Han Yang, Xia Deng, Yawei Yuan
BACKGROUND: Increasing evidence indicates that the dysregulation of microRNAs (miRNAs) play critical roles tumor progression and metastasis, but very few papers had reported the function of miR-9-5p in lung cancer, especially in NSCLCs. METHODS: In this study, we investigated the role of miR-9-5p in non-small cell lung cancers (NSCLCs). MiR-9-5p level were analyzed in 62 clinical NSCLC lung tissue samples and adjacent normal lung tissues by RT-PCR. The target of miR-9-5p was predicted by TargetScan and luciferase reporter assay was used to verify the binding site of miR-9-5p on TGFBR2 mRNA...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29239502/insecticide-susceptibility-status-of-invasive-aedes-albopictus-across-dengue-endemic-districts-of-odisha-india
#11
Animesha Rath, Ipsita Mohanty, Rupenangshu K Hazra
BACKGROUND: Aedes albopictus is currently the most invasive mosquito species in the world. Keeping in view the wide emergence of insecticide resistance, it is imperative to focus on the current susceptibility status for various insecticides in Ae. albopictus. The present study is focused on understanding the insecticide resistance mechanism of Ae. albopictus collected from dengue endemic districts of Odisha. RESULTS: Insecticide resistance was evaluated by using standardized bioassay kits (WHO) and biochemical analysis...
December 14, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29239468/the-importance-of-risk-factors-for-the-prediction-of-patients-with-invasive-pulmonary-aspergillosis
#12
Selçuk Kaya, Eda Gençalioğlu, Mehmet Sönmez, Iftihar Köksal
OBJECTIVE: Invasive pulmonary aspergillosis (IPA) is a major challenge in the management of immunocompromised patients. Despite all the advances in diagnosis, it remains a problem. The purpose of our study was to investigate the risk factors associated with IPA seen in patients with hematological malignancies. METHOD: A total of 152 febrile neutropenia (FEN) patients with hematological malignancies aged over 18 years and receiving high-dose chemotherapy or stem cell transplant between January 1, 2010, and December 31, 2012 were included in the study...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29239467/the-impact-of-anemia-and-body-mass-index-bmi-on-neuromotor-development-of-preschool-children
#13
Selen Ozakar Akca, Mehmet Ömer Bostanci
OBJECTIVE: According to data from the World Health Organization (WHO), anemia is a prevalent health problem that leads to increased morbidity and mortality, especially in preschool children. Anemia is recognized as a major health problem due to its negative effects on the mental and physical development during childhood. The aim of our study was to determine the levels of anemia of children in a kindergarten affiliated to the Directorate of National Education using a non-invasive method, and to investigate the effects of anemia on the physical, mental and neuromotor development of children...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29239149/agreement-between-ccnexfin-co-trek-cardiac-output-and-intermittent-cold-bolus-pulmonary-thermodilution-in-a-prospective-multi-centre-study
#14
Nicolaas H Sperna Weiland, Jim W de Wever, Yoni van Duivenvoorde, Christa Boer, Ludmil Mitrev, Muhammad Muntazar, Kinjal Patel, Markus W Hollmann, Benedikt Preckel
BACKGROUND: The ccNexfin system uses the CO-trek algorithm to analyse a non-invasively obtained arterial pressure waveform and calculate cardiac output (NEXCO). It remains matter of debate whether NEXCO can replace invasive, pulmonary artery catheter derived, cold-bolus pulmonary thermodilution cardiac output measurement (PACCO). This study aimed at testing NEXCO-PACCO agreement in a large sample size, multi-centre study. We hypothesized that agreement between NEXCO and PACCO would be demonstrated by a mean accuracy (bias) < 0...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29239068/estimating-chronic-hepatitis-c-prognosis-using-transient-elastography-based-liver-stiffness-a-systematic-review-and-meta-analysis
#15
Aysegul Erman, Abhinay Sathya, Austin Nam, Joanna M Bielecki, Jordan J Feld, Hla-Hla Thein, William W L Wong, Paul Grootendorst, Murray D Krahn
Chronic hepatitis C (CHC) is a leading cause of hepatic fibrosis and cirrhosis. The level of fibrosis is traditionally established by histology and prognosis is estimated using fibrosis progression rates (FPRs; annual probability of progressing across histological stages). However, newer non-invasive alternatives are quickly replacing biopsy. One alternative, transient elastography (TE), quantifies fibrosis by measuring liver stiffness (LSM). Given these developments, the purpose of this study was (1) to estimate prognosis in treatment-naïve CHC patients using TE-based liver stiffness progression rates (LSPR) as an alternative to FPRs and (2) to compare consistency between LSPRs and FPRs...
December 14, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#16
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239040/molecular-pathology-of-thyroid-tumours-of-follicular-cells-a-review-of-genetic-alterations-and-their-clinicopathological-relevance
#17
REVIEW
Giorgia Acquaviva, Michela Visani, Andrea Repaci, Kerry J Rhoden, Dario de Biase, Annalisa Pession, Tallini Giovanni
Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical example), have been, respectively, associated with conventional papillary carcinoma, follicular-patterned tumours (follicular adenoma, follicular carcinoma, and the follicular variant of papillary carcinoma/non-invasive follicular thyroid neoplasm with papillary-like nuclear features), and with papillary carcinomas from young patients and arising after exposure to ionising radiation, respectively...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239036/a-user-s-guide-to-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#18
REVIEW
Yin P Hung, Justine A Barletta
The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently introduced to replace a subset of follicular variant of papillary thyroid carcinoma (FVPTC). The goal of this change was to promote more conservative management of these tumours and spare patients the psychological burden of a cancer diagnosis. The histological diagnosis of NIFTP is stringent: the tumour needs to demonstrate encapsulation or circumscription, a purely follicular architecture and the presence of nuclear features of papillary thyroid carcinoma, while lacking capsular and vascular invasion, a significant component of solid growth and high-grade features (increased mitotic activity and necrosis)...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238923/endoscopic-therapy-and-curative-effect-in-pituitary-adenoma-patients-complicated-by-acromegalic-cardiomyopathy
#19
Heping Zhou, Zhengjiang Zha, Xiangdong Li, Xinsheng Chen, Jing Wang, Zhongzhou Su
The study aimed to retrospectively analyze the clinical characteristics of patients with pituitary adenomas complicated by acromegalic cardiomyopathy and to evaluate the effect of endoscopic surgery. Eighty-six pituitary adenoma patients complicated by acromegalic cardiomyopathy who were treated with endoscopic surgery in the First Affiliated Hospital of Soochow University from January 2010 to December 2016 were enrolled. We noted patient clinical characteristics and explored the relationships with surgical treatment...
December 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29238879/the-small-vesicular-culprits-the-investigation-of-extracellular-vesicles-as-new-targets-for-cancer-treatment
#20
REVIEW
Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa, Takahiro Ochiya
Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and proteins, from one cell to another, affecting the target cells. Emerging evidence suggests that reciprocal interactions between cancer cells and the cells in their microenvironment via EVs drive disease progression and therapy resistance. Therefore, understanding the roles of EVs in cancer biology will provide us with new opportunities to treat patients...
December 13, 2017: Clinical and Translational Medicine
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