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Natural health product regulation

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https://www.readbyqxmd.com/read/28430357/reactive-oxygen-species-key-regulators-in-vascular-health-and-diseases
#1
REVIEW
Qishan Chen, Qiwen Wang, Jianhua Zhu, Qingzhong Xiao, Li Zhang
Reactive oxygen species (ROS) are a group of small reactive molecules that play critical roles in the regulation of various cell functions and biological processes. In the vascular system, physiological levels of ROS are essential for normal vascular functions including endothelial homeostasis and smooth muscle cell contraction. In contrast, uncontrolled overproduction of ROS resulted from imbalance of ROS generation and elimination, leads to the development of vascular diseases. Excessive ROS cause vascular cell damages, recruitment of inflammatory cells, lipid peroxidation, activation of metalloproteinases, and deposition of extracellular matrix, collectively leading to vascular remodeling...
April 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28411721/ergonomic-analysis-of-construction-worker-s-body-postures-using-wearable-mobile-sensors
#2
Nipun D Nath, Reza Akhavian, Amir H Behzadan
Construction jobs are more labor-intensive compared to other industries. As such, construction workers are often required to exceed their natural physical capability to cope with the increasing complexity and challenges in this industry. Over long periods of time, this sustained physical labor causes bodily injuries to the workers which in turn, conveys huge losses to the industry in terms of money, time, and productivity. Various safety and health organizations have established rules and regulations that limit the amount and intensity of workers' physical movements to mitigate work-related bodily injuries...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28389979/species-adulteration-in-the-herbal-trade-causes-consequences-and-mitigation
#3
REVIEW
Ramanujam Srirama, J U Santhosh Kumar, G S Seethapathy, Steven G Newmaster, S Ragupathy, K N Ganeshaiah, R Uma Shaanker, Gudasalamani Ravikanth
The global economy of the international trade of herbal products has been increasing by 15% annually, with the raw material for most herbal products being sourced from South and Southeast Asian countries. In India, of the 8000 species of medicinal plants harvested from the wild, approximately 960 are in the active trade. With increasing international trade in herbal medicinal products, there is also increasing concern about the widespread adulteration and species admixtures in the raw herbal trade. The adverse consequences of such species adulteration on the health and safety of consumers have only recently begun to be recognised and documented...
April 8, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28362806/evolved-genetic-and-phenotypic-differences-due-to-mitochondrial-nuclear-interactions
#4
Tara Z Baris, Dominique N Wagner, David I Dayan, Xiao Du, Pierre U Blier, Nicolas Pichaud, Marjorie F Oleksiak, Douglas L Crawford
The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only pathway with both nuclear and mitochondrial encoded proteins. The importance of the interactions between these two genomes has recently received more attention because of their potential evolutionary effects and how they may affect human health and disease. In many different organisms, healthy nuclear and mitochondrial genome hybrids between species or among distant populations within a species affect fitness and OxPhos functions...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28351344/why-do-women-choose-an-unregulated-birth-worker-to-birth-at-home-in-australia-a-qualitative-study
#5
Elizabeth Christine Rigg, Virginia Schmied, Kath Peters, Hannah Grace Dahlen
BACKGROUND: In Australia the choice to birth at home is not well supported and only 0.4% of women give birth at home with a registered midwife. Recent changes to regulatory requirements for midwives have become more restrictive and there is no insurance product that covers private midwives for intrapartum care at home. Freebirth (planned birth at home with no registered health professional) with an unregulated birth worker who is not a registered midwife or doctor (e.g. Doula, ex-midwife, lay midwife etc...
March 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28319389/potential-antiosteoporotic-natural-product-lead-compounds-that-inhibit-17%C3%AE-hydroxysteroid-dehydrogenase-type-2
#6
Anna Vuorinen, Roger T Engeli, Susanne Leugger, Fabio Bachmann, Muhammad Akram, Atanas G Atanasov, Birgit Waltenberger, Veronika Temml, Hermann Stuppner, Liselotte Krenn, Sylvin B Ateba, Dieudonné Njamen, Rohan A Davis, Alex Odermatt, Daniela Schuster
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the active steroid hormones estradiol, testosterone, and 5α-dihydrotestosterone into their weakly active forms estrone, Δ(4)-androstene-3,17-dione, and 5α-androstane-3,17-dione, respectively, thereby regulating cell- and tissue-specific steroid action. As reduced levels of active steroids are associated with compromised bone health and onset of osteoporosis, 17β-HSD2 is considered a target for antiosteoporotic treatment. In this study, a pharmacophore model based on 17β-HSD2 inhibitors was applied to a virtual screening of various databases containing natural products in order to discover new lead structures from nature...
March 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28289384/theabrownin-inhibits-cell-cycle-progression-and-tumor-growth-of-lung-carcinoma-through-c-myc-related-mechanism
#7
Li Zhou, Feifei Wu, Wangdong Jin, Bo Yan, Xin Chen, Yingfei He, Weiji Yang, Wenlin Du, Qiang Zhang, Yonghua Guo, Qiang Yuan, Xiaoqiao Dong, Wenhua Yu, Jin Zhang, Luwei Xiao, Peijian Tong, Letian Shan, Thomas Efferth
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage but also a traditional Chinese medicine used for prevention or treatment of cancer, such as lung cancer. Theabrownin (TB) is the main fraction responsible for the medicinal effects of green tea, but whether it possesses anti-cancer effect is unknown yet. This study aimed to determine the in vitro and in vivo anti-lung cancer effect of TB and explore the underlying molecular mechanism, by using A549 cell line and Lewis lung carcinoma-bearing mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28273266/-the-right-to-food-in-obesogenic-environments-reflections-on-the-role-of-health-professionals
#8
Laura Raquel Piaggio
Faced with the current obesity epidemic, this article problematizes the way the right to food is often circumscribed to situations of nutritional deficit. It is argued that the right to adequate food is violated in obesogenic environments and that protection of the right requires the establishment of measures to regulate advertising and marketing practices regarding ultra-processed products. The work suggests that the main barriers to the implementation of such measures are the strategies employed by Big Food; among these, strategies that have the scientific community as a target and/or means are highlighted...
October 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28262114/micrornas-mediate-therapeutic-and-preventive-effects-of-natural-agents-in-breast-cancer
#9
REVIEW
Zhipin Liang, Yaguang Xi
MicroRNAs (miRNAs) are a set of non-coding small RNA molecules that play a critical role in regulation of protein coding genes in cells. MiRNAs have been extensively studied as novel biomarkers, therapeutic targets, and new drugs in various human diseases. Breast cancer is a one of the leading tumor types significantly affecting women health worldwide. Over the past decade, a number of natural agents, such as paclitaxel and curcumin, have been applied for treatment and prevention of breast cancer due to their relatively low toxicity...
December 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28244671/prebiotic-inulin-type-fructans-and-galacto-oligosaccharides-definition-specificity-function-and-application-in-gastrointestinal-disorders
#10
REVIEW
Bridgette Wilson, Kevin Whelan
Prebiotics are non-digestible selectively fermented dietary fibers that specifically promote the growth of one or more bacterial genera in the gastrointestinal tract and thus provide health benefit to the host. The two most investigated prebiotics being the inulin-type fructans and galacto-oligosaccharides. Prebiotic specificity is mediated through species-specific gene clusters within saccharolytic bacteria controlled by signaling sensors for various substrates. Prebiotic health benefits are attributed to immune regulation and bacterial metabolite production...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28242592/perceptions-of-menthol-cigarettes-among-twitter-users-content-and-sentiment-analysis
#11
Shyanika W Rose, Catherine L Jo, Steven Binns, Melissa Buenger, Sherry Emery, Kurt M Ribisl
BACKGROUND: Menthol cigarettes are used disproportionately by African American, female, and adolescent smokers. Twitter is also used disproportionately by minority and younger populations, providing a unique window into conversations reflecting social norms, behavioral intentions, and sentiment toward menthol cigarettes. OBJECTIVE: Our purpose was to identify the content and frequency of conversations about menthol cigarettes, including themes, populations, user smoking status, other tobacco or substances, tweet characteristics, and sentiment...
February 27, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28216605/an-overview-of-stress-induced-resveratrol-synthesis-in-grapes-perspectives-for-resveratrol-enriched-grape-products
#12
REVIEW
Mohidul Hasan, Hanhong Bae
Resveratrol is the most important stilbene phytoalexin synthesized naturally or induced in plants, as a part of their defense mechanism. Grapes and their derivative products, including juice and wine, are the most important natural sources of resveratrol, consisting of notably higher amounts than other natural sources like peanuts. Consumption of red wine with its presence of resveratrol explained the "French Paradox". Hence, the demand of resveratrol from grapes is increasing. Moreover, as a natural source of resveratrol, grapes became very important in the nutraceutical industry for their benefits to human health...
February 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28216385/the-role-of-mitochondria-in-cardiac-development-and-protection
#13
REVIEW
Jaakko L Pohjoismäki, Steffi Goffart
Mitochondria are essential for the development as well as maintenance of the myocardium, the most energy consuming tissue in the human body. Mitochondria are not only a source of ATP energy but also generators of reactive oxygen species (ROS), that cause oxidative damage, but also regulate physiological processes such as the switch from hyperplastic to hypertrophic growth after birth. As excess ROS production and oxidative damage are associated with cardiac pathology, it is not surprising that much of the research focused on the deleterious aspects of free radicals...
February 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28193870/disruption-of-quercetin-metabolism-by-fungicide-affects-energy-production-in-honey-bees-apis-mellifera
#14
Wenfu Mao, Mary A Schuler, May R Berenbaum
Cytochrome P450 monooxygenases (P450) in the honey bee, Apis mellifera, detoxify phytochemicals in honey and pollen. The flavonol quercetin is found ubiquitously and abundantly in pollen and frequently at lower concentrations in honey. Worker jelly consumed during the first 3 d of larval development typically contains flavonols at very low levels, however. RNA-Seq analysis of gene expression in neonates reared for three days on diets with and without quercetin revealed that, in addition to up-regulating multiple detoxifying P450 genes, quercetin is a negative transcriptional regulator of mitochondrion-related nuclear genes and genes encoding subunits of complexes I, III, IV, and V in the oxidative phosphorylation pathway...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28186077/designing-a-surveillance-system-in-canada-to-detect-adverse-interactions-between-traditional-chinese-medicine-and-western-medicine-issues-and-considerations
#15
Jingfei Zhang, Kendall Ho
The use of Chinese medicinal materials (CMM) in the context of Traditional Chinese Medicine (TCM) is increasingly prevalent in Canada and worldwide. Self-medication with CMM and concurrent usage with Western medicine are also common. While taking CMM carries recognized risk of adverse effects on their own, their interactions with Western medicine can further generate additional adverse effects but are largely underestimated and undetected due to under-reporting. This is especially true in Canada and other Western countries where CMM is regulated as natural products...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28152355/what-risks-do-herbal-products-pose-to-the-australian-community
#16
Roger W Byard, Ian Musgrave, Garth Maker, Michael Bunce
Traditional herbal products are widely used in Australia to treat a broad range of conditions and diseases. It is popularly believed that these products are safer than prescribed drugs. While many may be safe, it is worrying that the specific effects and harmful interactions of a number of their components with prescription medications is not well understood. Some traditional herbal preparations contain heavy metals and toxic chemicals, as well as naturally occurring organic toxins. The effects of these substances can be dire, including acute hepatic and renal failure, exacerbation of pre-existing conditions and diseases, and even death...
February 6, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28110066/bioactive-nutrients-time-for-tolerable-upper-intake-levels-to-address-safety
#17
REVIEW
Allison A Yates, John W Erdman, Andrew Shao, Laurie C Dolan, James C Griffiths
There is increasing interest by consumers, researchers, and regulators into the roles that certain bioactive compounds, derived from plants and other natural sources, can play in health maintenance and promotion, and even prolonging a productive quality of life. Research has rapidly emerged suggesting that a wide range of compounds and mixtures in and from plants (such as fruits and vegetables, tea and cocoa) and animals (such as fish and probiotics) may exert substantial health benefits. There is interest in exploring the possibility of establishing recommended intakes or dietary guidance for certain bioactive substances to help educate consumers...
March 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#18
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28081361/microbial-transformation-of-multiwalled-carbon-nanotubes-by-mycobacterium-vanbaalenii-pyr-1
#19
Yaqi You, Kamol K Das, Huiyuan Guo, Che-Wei Chang, Maria Navas-Moreno, James W Chan, Paul Verburg, Simon R Poulson, Xilong Wang, Baoshan Xing, Yu Yang
Carbonaceous nanomaterials are widely used in industry and consumer products, but concerns have been raised regarding their release into the environment and subsequent impacts on ecosystems and human health. Although many efforts have been devoted to understanding the environmental fate of carbonaceous nanomaterials, information about their microbial transformation is still rare. In this study, we found that within 1 month a polycyclic aromatic hydrocarbon-degrading bacterium, Mycobacterium vanbaalenii PYR-1, was able to degrade both pristine and carboxyl-functionalized multiwalled carbon nanotubes (p-MWCNT and c-MWCNT), as demonstrated by consistent results from high resolution transmission electron microscopy, Raman spectroscopy, and confocal Raman microspectroscopy...
February 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28075542/considering-marijuana-legalization-carefully-insights-for-other-jurisdictions-from-analysis-for-vermont
#20
Jonathan P Caulkins, Beau Kilmer
BACKGROUND AND AIMS: In 2014 the legislature of Vermont, USA passed a law requiring the Secretary of Administration to report on the consequences of legalizing marijuana. The RAND Corporation was commissioned to write that report. This paper summarizes insights from that analysis that are germane to other jurisdictions. METHOD: Translation of key findings from the RAND Corporation report to the broader policy debate. RESULTS: Marijuana legalization encompasses a wide range of possible regimes, distinguished along at least four dimensions: which organizations are allowed to produce and supply the drug, the regulations under which they operate, the nature of the products that can be distributed and taxes and prices...
December 2016: Addiction
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