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https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#1
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29217830/patient-reported-quality-of-life-progression-in-men-with-prostate-cancer-following-primary-cryotherapy-cyberknife-or-active-holistic-surveillance
#2
Glenn T Werneburg, Michael Kongnyuy, Daniel M Halpern, Jose M Salcedo, Kaitlin E Kosinski, Jonathan A Haas, Jeffrey T Schiff, Anthony T Corcoran, Aaron E Katz
BACKGROUND: Technological advancements have led to the success of minimally invasive treatment modalities for prostate cancer such as CyberKnife and Cryotherapy. Here, we investigate patient-reported urinary function, bowel habits, and sexual function in patients following CyberKnife (CK) or Cryotherapy treatment, and compare them with active holistic surveillance (AHS) patients. METHODS: An IRB-approved institutional database was retrospectively reviewed for patients who underwent CK, Cryotherapy, or AHS...
December 7, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29217241/myocardial-protection-in-mitral-valve-surgery-comparison-between-minimally-invasive-approach-and-standard-sternotomy
#3
Jean-Sébastien Lebon, Pierre Couture, Annik Fortier, Antoine G Rochon, Christian Ayoub, Claudia Viens, Éric Laliberté, Denis Bouchard, Michel Pellerin, Alain Deschamps
OBJECTIVE: To compare antegrade and retrograde cardioplegia administration in minimally invasive mitral valve surgery (MIMS) and open mitral valve surgery (OMS) for myocardial protection. DESIGN: Retrospective study. SETTING: Tertiary care university hospital. PARTICIPANTS: The study comprised 118 patients undergoing MIMS and 118 patients undergoing OMS. INTERVENTIONS: The data of patients admitted for MIMS from 2006 to 2010 were reviewed...
August 30, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29214418/choice-of-desflurane-or-propofol-for-the-maintenance-of-general-anesthesia-does-not-affect-the-risk-of-periprocedural-myocardial-damage-in-patients-undergoing-transfemoral-transcatheter-aortic-valve-implantation
#4
Kenta Okitsu, Takeshi Iritakenishi, Tatsuyuki Imada, Michioki Kuri, Sho Carl Shibata, Yuji Fujino
PURPOSE: This study aimed to reveal whether the occurrence of periprocedural myocardial damage (PMD) decreases in patients who received volatile anesthetics to maintain general anesthesia compared with those who received propofol during transcatheter aortic valve implantation (TAVI). METHODS: We included one hundred and forty adult patients who underwent transfemoral TAVI under general anesthesia from January 2015 to March 2017 in this single-center retrospective review...
December 6, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29212219/microrna-126a-5p-enhances-myocardial-ischemia-reperfusion-injury-through-suppressing-hspb8-expression
#5
Bimei Jiang, Yanjuan Liu, Pengfei Liang, Yuanbin Li, Zhenguo Liu, Zhongyi Tong, Qinglan Lv, Meidong Liu, Xianzhong Xiao
Previously, we found several genes are involved in myocardial ischemia-reperfusion (M-I/R) injury. In this report, we first developed a mouse model of M-I/R injury and demonstrated microRNA-126a-5p was associated with the M-I/R injury by using high-throughput microRNA expression analysis. We further investigated the expression and function of microRNA-126a-5p during mouse M-I/R injury. We observed high expression of microRNA-126a-5p in the M-I/R mice and increased levels of LDH and CK-MB (damage markers) in the serum...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209878/cell-type-specific-spatiotemporal-expression-of-creatine-biosynthetic-enzyme-s-adenosylmethionine-guanidinoacetate-n-methyltransferase-in-developing-mouse-brain
#6
Masanori Tachikawa, Masahiko Watanabe, Masahiro Fukaya, Kazuhisa Sakai, Tetsuya Terasaki, Ken-Ichi Hosoya
Creatine is synthesized by S-adenosylmethionine:guanidinoacetate N-methyltransferase (GAMT), and the creatine/phosphocreatine shuttle system mediated by creatine kinase (CK) is essential for storage and regeneration of high-energy phosphates in cells. Although the importance of this system in brain development is evidenced by the hereditary nature of creatine deficiency syndrome, the spatiotemporal cellular expression patterns of GAMT in developing brain remain unknown. Here we show that two waves of high GAMT expression occur in developing mouse brain...
December 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29209666/novel-duplication-mutation-of-the-dysf-gene-in-a-pakistani-family-with-miyoshi-myopathy
#7
Muhammad I Ullah, Arsalan Ahmad, Milena Zarkovic, Syed S Shah, Abdul Nasir, Saqib Mahmood, Wasim Ahmad, Christian A Hubner, Muhammad J Hassan
To identify the underlying gene mutation in a large consanguineous Pakistani family.  Methods: This is an observational descriptive study carried out at the Department of Biochemistry, Shifa International Hospital, Quaid-i-Azam University, and Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan from 2013-2016. Genomic DNA of all recruited family members was extracted and the Trusight one sequencing panel was used to assess genes associated with a neuro-muscular phenotype...
December 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29209343/vermicompost-improves-tomato-yield-and-quality-and-the-biochemical-properties-of-soils-with-different-tomato-planting-history-in-a-greenhouse-study
#8
Xin-Xin Wang, Fengyan Zhao, Guoxian Zhang, Yongyong Zhang, Lijuan Yang
A greenhouse pot test was conducted to study the impacts of replacing mineral fertilizer with organic fertilizers for one full growing period on soil fertility, tomato yield and quality using soils with different tomato planting history. Four types of fertilization regimes were compared: (1) conventional fertilizer with urea, (2) chicken manure compost, (3) vermicompost, and (4) no fertilizer. The effects on plant growth, yield and fruit quality and soil properties (including microbial biomass carbon and nitrogen, [Formula: see text]-N, [Formula: see text]-N, soil water-soluble organic carbon, soil pH and electrical conductivity) were investigated in samples collected from the experimental soils at different tomato growth stages...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29208505/toxicological-analysis-of-roast-duck-flavor-components
#9
Yiming Zhou, Beibei Yan, Shen Zhao, Xiaoli Zhou, Ying Xiao
The aim of the study was to investigate toxicity of the synthesized roast duck flavor through animal experiment (mice feeding with the flavor for 35 days), and the major toxic compounds (acrylamide and 3,4-benzopyrene) were detected by high performance liquid chromatography. Compared with the control group, the blood biochemical indexes including protein content, bilirubin content, activity of alkaline phosphatase, activity of aspartate transaminase (AST) and alanine transaminase (ALT), cholesterol content, high density lipoprotein (HDL) and low density lipoprotein (LDL) content, triglycerides content, activity of creatine kinase (CK) and CK-MB, activity of cholinesterase (CHE) and lactate dehydrogenase (LDH), total bile acid (TBA) in high dose feeding group were significantly different...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29208215/plasma-potassium-concentrations-in-neonatal-diarrhoeic-calves-are-correlated-with-serum-aldosterone-concentrations-but-not-with-insulin-concentrations
#10
Florian M Trefz, Ingrid Lorenz
Hyperkalaemia is a clinically relevant electrolyte imbalance in neonatal diarrhoeic calves which was previously associated with severe dehydration and acidaemia. The present study assessed the association of plasma potassium (cK) with serum aldosterone and insulin concentrations, since these hormones are involved in the regulation of potassium homeostasis. Serum aldosterone (rs=0.62), but not insulin concentrations (rs=0.22) were closely correlated to cK in 123 hospitalised neonatal diarrhoeic calves. Median values for serum aldosterone concentrations in 38 hyperkalaemic calves (cK>5...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29207777/an-aggressive-primary-retroperitoneal-diffuse-large-b-cell-lymphoma-mimicking-a-pancreatic-neoplasm-presenting-as-duodenal-stenosis
#11
Bharadhwaj Ravindhran, Clement Prakash, Sridar Govindharaj, Noor Mohammed Shawnaz Bahnou, B Pavithra
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's Lymphoma (NHL). Primary retroperitoneal DLBCL is uncommon and has seldom been reported. Extrinsic compression of the duodenum due to lesions originating from the retroperitoneum is also rare. We present a case of a 39-year-old man who presented with inability to tolerate oral intake, abdominal pain, an upper abdominal mass and postprandial bilious vomiting caused by a large DLBCL arising from the retroperitoneum causing extrinsic compression of the duodenum...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207388/resveratrol-does-not-protect-from-ischemia-induced-acute-kidney-injury-in-an-in-vivo-rat-model
#12
Anja Bienholz, Rahel Mae Pang, Hana Guberina, Ursula Rauen, Oliver Witzke, Benjamin Wilde, Frank Petrat, Thorsten Feldkamp, Andreas Kribben
BACKGROUND/AIMS: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. METHODS: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping...
December 5, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29204944/comparison-of-culture-media-indicates-a-role-for-autologous-serum-in-enhancing-phenotypic-preservation-of-rabbit-limbal-stem-cells-in-explant-culture
#13
Mehmet Gürdal, Özlem Barut Selver, Kemal Baysal, İsmet Durak
In this study, we aimed to compare the effects of six different cell culture media and autologous serum (AS) on the phenotypic characteristics of rabbit limbal epithelial stem cells (LESC) cultivated on porous polyethylene terephthalate (PET) membranes. Limbal explants from rabbit corneas were grown on PET membrane inserts in five different media: DMEM-F12 with fetal bovine serum (FBS) (DMEM-F12-FBS), with pluripotin (DMEM-F12-pluripotin) and with autologous serum (DMEM-F12-AS), Epilife, Keratinocyte Serum Free Medium (KSFM) and Defined-Keratinocyte Serum Free Medium...
December 4, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29204057/novel-d-galactosamine-induced-cynomolgus-monkey-model-of-acute-liver-failure
#14
Lei Feng, Lei Cai, Guo-Lin He, Jun Weng, Yang Li, Ming-Xin Pan, Ze-Sheng Jiang, Qing Peng, Yi Gao
AIM: To establish a simplified, reproducible D-galactosamine-induced cynomolgus monkey model of acute liver failure having an appropriate treatment window. METHODS: Sixteen cynomolgus monkeys were randomly divided into four groups (A, B, C and D) after intracranial pressure (ICP) sensor implantation. D-galactosamine at 0.3, 0.25, 0.20 + 0.05 (24 h interval), and 0.20 g/kg body weight, respectively, was injected via the small saphenous vein. Vital signs, ICP, biochemical indices, and inflammatory factors were recorded at 0, 12, 24, 36, 48, 72, 96, and 120 h after D-galactosamine administration...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29204018/role-of-biomarkers-in-differentiating-new-onset-seizures-from-psychogenic-nonepileptic-seizures
#15
Mahendra Javali, Purushottam Acharya, Shripal Shah, Rohan Mahale, Pushparaja Shetty, Srinivasa Rangasetty
Introduction: Review of literature revealed very limited studies considering a combination of serum prolactin (PRL) and serum creatine kinase (CK) as markers for differentiating epileptic and psychogenic nonepileptic seizures (PNES). Therefore, in the present study, we analyzed the role of serum PRL and serum CK, individually and in combination. Methodology: This prospective study was conducted in a tertiary care medical teaching hospital over a period of 18 months...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29201152/myocardial-injury-in-diabetic-patients-with-multivessel-coronary-artery-disease-after-revascularization-interventions
#16
Paulo Cury Rezende, Whady Hueb, Rosa Maria Rahmi, Thiago Luis Scudeler, Diogo Freitas Cardoso de Azevedo, Cibele Larrosa Garzillo, Carlos Alexandre Wainrober Segre, Jose Antonio Franchini Ramires, Roberto Kalil Filho
Background: Diabetic patients may be more susceptible to myocardial injury after coronary interventions. Thus, the aim of this study was to assess the release of cardiac biomarkers, CK-MB and troponin, and the findings of new late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in patients with type 2 diabetes mellitus after elective revascularization procedures for multivessel coronary artery disease (CAD). Methods: Patients with multivessel CAD and preserved systolic ventricular function underwent either elective percutaneous coronary intervention (PCI), off-pump or on-pump bypass surgery (CABG)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29200983/the-short-term-effect-of-high-versus-moderate-protein-intake-on-recovery-after-strength-training-in-resistance-trained-individuals
#17
Justin Roberts, Anastasia Zinchenko, Craig Suckling, Lee Smith, James Johnstone, Menno Henselmans
Background: Dietary protein intakes up to 2.9 g.kg-1.d-1 and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29200908/ursolic-acid-supplementation-decreases-markers-of-skeletal-muscle-damage-during-resistance-training-in-resistance-trained-men-a-pilot-study
#18
Hyun Seok Bang, Dae Yun Seo, Young Min Chung, Do Hyung Kim, Sam-Jun Lee, Sung Ryul Lee, Hyo-Bum Kwak, Tae Nyun Kim, Min Kim, Kyoung-Mo Oh, Young Jin Son, Sanghyun Kim, Jin Han
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200889/mesenchymal-phenotype-of-circulating-tumor-cells-is-associated-with-distant-metastasis-in-breast-cancer-patients
#19
Shirong Zhang, Tiecheng Wu, Xinguo Peng, Jian Liu, Fang Liu, Shiyang Wu, Suyan Liu, Yan Dong, Shujun Xie, Shenglin Ma
In this study, we investigated the relationship between the epithelial-mesenchymal transition phenotype of circulating tumor cells (CTCs) and distant metastasis in breast cancer patients. We analyzed the expression of epithelial (epithelial cell adhesion molecule, cytokeratin [CK]8, CK18 and CK19) and mesenchymal (vimentin and TWIST1) markers in CTCs from a large cohort of Chinese breast cancer patients (N=1083) using Canpatrol™ CTC assays. We identified CTCs in 84.9% (920/1083) of the breast cancer patients enrolled in this study...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29197450/obesity-may-be-a-risk-factor-for-progression-of-periodontal-attachment-loss-in-women
#20
Mishali Alsharief, Eman Aljoghaiman
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Effect of obesity on periodontal attachment loss progression: a 5-year population-based prospective study. Gaio EJ, Haas AN, Rösing CK, Opermann RV, Albandar JM, Susin C. J Clin Periodontol 2016;43(7): 557-65. SOURCE OF FUNDING: Foundation for Post-Graduate Education (CAPES), Brasilia, Brazil (grant #1614/99-1) Foundation for Research of Rio Grande do Sul, Porto Alegre, Brazil (grant #PPSUS-0700481) TYPE OF STUDY/DESIGN: Cohort Study...
December 2017: Journal of Evidence-based Dental Practice
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