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https://www.readbyqxmd.com/read/29665648/ischemia-reperfusion-injury-in-male-guinea-pigs-an-efficient-model-to-investigate-myocardial-damage-in-cardiovascular-complications
#1
Divya Dasagrandhi, Arul Salomee Kamalabai R, Anusuyadevi Muthuswamy, Angela Marie Lennox, Tamilselvan Jayavelu, Vasudharani Devanathan, Jayachandran Kesavan Swaminathan
Myocardial ischemia/reperfusion (I/R) injury is the major problem that aggravates cardiac damage. Several established animal models fail to explain the similarity in disease mechanism and progression as seen in humans; whereas guinea pig shows high similarity in cardiovascular parameters. Hence, current study is aimed to develop an animal model using guinea pigs that may best correlate with disease mechanism of human myocardial I/R injury. Male guinea pigs were randomized into three groups: normal diet (ND), high fat diet (HFD) and sham; fed with respective diets for 90 days...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664002/-research-of-the-heart-protective-effect-of-exercise-precondition-mediated-by-calcitonin-gene-related-peptide-on-acute-exhaustion-rats
#2
Zhao Zhang, Yang Wang, Peng Xu, Yingkai Cui, Wang Li, Xuebin Cao
OBJECTIVE: To observe the heart protective effect of exercise preconditioning (EP) in the acute exhaustion exercise (EE) rats, and explore its action mechanism further. METHODS: Eighty healthy male Sprague-Dawley (SD) rats were divided into control group (C group), EP group, EE group, and EP+EE group randomly, with 20 rats in each group. The rats in EP and EP+EE groups were trained for 3 weeks according to the daily swimming for 60 minutes (swimming 15 minutes, resting 5 minutes, repeating 3 times) with 6 days each week...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29664001/-protective-effect-of-mild-hypothermia-at-different-starting-times-on-organ-function-in-patient-with-exertional-heat-stroke
#3
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To investigate the protective effect of mild hypothermia at different starting times on the physiological functions of the viscera of exertional heat stroke (EHS). METHODS: A prospective randomized controlled trial was conducted. EHS patients admitted to intensive care unit of the 159th Hospital of People's Liberation Army and the First Affiliated Hospital of Zhengzhou University from June 2015 to June 2017 were enrolled. The patients were divided into 2, 4, 6 hours start hypothermia treatment groups according to the random number table method, the mild hypothermia was initiated at 2, 4 and 6 hours after the disease onset respectively, and the methods were the same in each group...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663994/-predictive-value-of-early-phrase-echocardiography-and-cardiac-biological-markers-in-patients-with-severe-sepsis-a-five-year-single-center-retrospective-study
#4
Xuefeng Zang, Wei Chen, Bo Sheng, Lei Zhao, Xuyun Gu, Jie Zhen, Ping Liu
OBJECTIVE: To assess the predictive value of early phrase echocardiography and cardiac biomarkers in patients with severe sepsis. METHODS: A retrospective analysis of severe septic patients (patients with acute coronary syndrome and end stage renal disease were excluded) in department of intensive care unit of Capital Medical University Affiliated Beijing Shijitan Hospital from January 2013 to December 2017 was conducted. The acute physiology and chronic health evaluation II (APACHE II) score, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), myoglobin (MYO), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB) within 6 hours after admission, and bedside echocardiography indexes [left ventricular ejection fraction (LVEF), the ratio of the peak blood flow velocity in the early stage of the mitral valve and the peak blood flow rate of the mitral valve (E/A ratio)] within 6 hours after diagnosis were recorded...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29662456/dynamic-regulation-of-circulating-micrornas-during-acute-exercise-and-long-term-exercise-training-in-basketball-athletes
#5
Yongqin Li, Mengchao Yao, Qiulian Zhou, Yan Cheng, Lin Che, Jiahong Xu, Junjie Xiao, Zhongming Shen, Yihua Bei
Emerging evidence indicates the beneficial effects of physical exercise on human health, which depends on the intensity, training time, exercise type, environmental factors, and the personal health status. Conventional biomarkers provide limited insight into the exercise-induced adaptive processes. Circulating microRNAs (miRNAs, miRs) are dynamically regulated in response to acute exhaustive exercise and sustained rowing, running and cycling exercises. However, circulating miRNAs in response to long-term basketball exercise remains unknown...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29659931/shade-compromises-the-photosynthetic-efficiency-of-nadp-me-less-than-pep-ck-and-nad-me-c4-grasses
#6
Balasaheb V Sonawane, Robert E Sharwood, Spencer Whitney, Oula Ghannoum
The high-energy cost and apparently low plasticity of C4 photosynthesis, compared to C3 photosynthesis, may limit the productivity and distribution of C4 plants in low light (LL) environments. C4 photosynthesis evolved numerous times but it remains unclear how different biochemical subtypes perform under LL. We grew eight C4 grasses belonging to three biochemical subtypes (NADP-ME, NAD-ME and PEP-CK) under shade (16% sunlight) or control (full sunlight) conditions and measured their photosynthetic characteristics at both low and high light...
April 5, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29659040/the-prognostic-value-of-monosomal-karyotype-mk-in-higher-risk-patients-with-myelodysplastic-syndromes-treated-with-5-azacitidine-a-retrospective-analysis-of-the-hellenic-greek-mds-study-group
#7
Sotirios G Papageorgiou, Diamantina Vasilatou, Christos K Kontos, Ioannis Kotsianidis, Argiris Symeonidis, Athanasios G Galanopoulos, Eleftheria Hatzimichael, Aekaterini Megalakaki, Elias Poulakidas, Panagiotis Diamantopoulos, Theodoros Vassilakopoulos, Panagiotis Zikos, Helen Papadaki, Despoina Mparmparousi, Eleni Bouronikou, Panayiotis Panayiotidis, Nora-Athina Viniou, Vassiliki Pappa
In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk MDS patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytogenetic risk defined according to IPSS-R, as well as with high-risk disease, according to IPSS (P=0.029), IPSS-R (P<0.001), and WPSS (P<0.001) classification systems. The overall response rate (ORR) was not different between MK+ and MK- patients (46...
April 16, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29655978/sitagliptin-prevents-isoproterenol-induced-myocardial-infarction-in-rats-by-modulating-nitric-oxide-synthase-enzymes
#8
Mohamed Abdellah Ibrahim, Ayman Geddawy, Soha Abdel-Wahab
Ischemic heart disease is a common cause of mortality worldwide. Sitagliptin is a new anti-diabetic drug acting as dipeptidyl peptidase-4 (DPP-4) inhibitor. The study investigated the ability of sitagliptin to prevent pathological changes of isoproterenol- (ISO-) induced myocardial injury in rats. The role of nitric oxide (NO) was also reported. Rats were assorted into six groups (n = 7) and treated for 12 days. Group 1: normal control, received normal saline. Group 2, sitagliptin control, received sitagliptin (10mg/kg, orally)...
April 12, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29652189/a-review-and-update-on-papillary-immature-metaplasia-of-the-uterine-cervix-a-distinct-subset-of-low-grade-squamous-intraepithelial-lesion-proposing-a-possible-cell-of-origin
#9
Soon Auck Hong, Su Hyun Yoo, Jene Choi, Stanley J Robboy, Kyu-Rae Kim
CONTEXT: - Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papilloma virus (LR-HPV). OBJECTIVE: - To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumptive cell of origin. DESIGN: - A total of 26 PIM cases were evaluated by p16INK4a , cytokeratin (CK) 7, and CK17 immunohistochemical stainings. Human papilloma virus genotyping was performed, by using HPV DNA Chip, HPV polymerase chain reaction (PCR), and real-time PCR...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29651216/linear-analysis-of-autonomic-activity-and-its-correlation-with-creatine-kinase-mb-in-overt-thyroid-dysfunctions
#10
Manisha Mavai, Yogendra Raj Singh, R C Gupta, Sandeep K Mathur, Bharti Bhandari
Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29648903/cardiotoxicity-of-anthracycline-ant-treatment-in-children-with-malignant-tumors
#11
Huimin Hu, Weiling Zhang, Dongsheng Huang, Qingmiao Yang, Jing Li, Yanan Gao
OBJECTIVE: To investigate the cardiotoxicity indexes in children with malignant tumors after the administration of anthracycline (ANT) chemotherapy. MATERIALS AND METHODS: Data from 131 children with malignant tumors who were treated using ANT chemotherapy at our hospital from January 2011 to December 2015 were collected to analyze the serologic indexes (such as N-terminal pro-brain natriuretic peptide [NT-proBNP] and isoenzyme of creatine kinase [CK-MB]) and changes in corrected QT interval(QT-c) and left ventricular ejection fraction (LVEF) before and after treatment with different ANT cumulative doses...
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29648463/protective-effect-of-thymoquinone-the-main-component-of-nigella-sativa-against-diazinon-cardio-toxicity-in-rats
#12
Gholam Hassan Danaei, Bahram Memar, Ramin Ataee, Mohammad Karami
Several studies have shown that oxidative stress and cell damage can occur at very early stages of diazinon (DZN) exposure. The present study was designed to determine the beneficial effect of thymoquinone (Thy), the main component of Nigella sativa (black seed or black cumin), against DZN cardio-toxicity in rats. In the present experimental study, 48 male Wistar rats were randomly divided into six groups: control (corn oil gavages), DZN gavages (20 mg/kg/day), Thy gavages (10 mg/kg/day) and Thy + DVN gavages (2...
April 12, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29643136/orbital-metastasis-from-an-occult-breast-carcinoma-t0-n1-m1
#13
Rita Pinto Proença, Júlia Fernandes, Miguel N Burnier, Rui Proença
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour...
April 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29630131/butorphanol-attenuates-myocardial-ischemia-reperfusion-injury-through-inhibiting-mitochondria-mediated-apoptosis-in-mice
#14
L-H Huang, J Li, J-P Gu, M-X Qu, J Yu, Z-Y Wang
OBJECTIVE: To investigate the role of the opioid receptors agonist butorphanol on mice myocardial ischemia reperfusion (I/R) injury. MATERIALS AND METHODS: The left anterior descending of coronary artery was ligatured for 30 min and then reperfusion for 6 h was performed to mimic the mouse myocardial I/R injury. All mice were randomly divided into three groups: sham group, I/R group and I/R + butorphanol group. Blood samples were collected for the measurement of cardiac troponin I (CTnI) and creatine kinase MB (CK-MB) levels...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630122/analysis-of-the-correlation-between-the-neutrophil-lymphocyte-ratio-in-peripheral-blood-and-perioperative-myocardial-damage-in-pediatric-patients-with-frequent-ventricular-premature-beat
#15
J Tian, X-J An, L Niu
OBJECTIVE: The objective of the present study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR) in peripheral blood and myocardial damage in pediatric patients with frequent ventricular premature beat (FVPB), and provide a reference for myocardial preservation in these patients. PATIENTS AND METHODS: A total of 212 pediatric patients who were treated in the Department of Cardiology, Xuzhou Children's Hospital between December 2014 and March 2016 for FVPB, were selected...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629646/fibroblastic-osteosarcoma-with-epithelioid-and-squamous-differentiation-in-a-dog
#16
Tiffany L Jenkins, Dalen Agnew, Daniel R Rissi
A fibroblastic osteosarcoma with epithelioid and squamous differentiation in the distal femur of a 9-y-old spayed female Greyhound dog is described. Grossly, the tumor consisted of a pale-white, firm-to-hard mass that replaced the medullary and cortical areas of the distal end of the right femur. Histologically, the mass was composed predominantly of spindle cells admixed with areas of mineralized and non-mineralized osteoid matrix that were surrounded by stellate osteoblasts and scattered multinucleate giant cells, consistent with the diagnosis of a fibroblastic osteosarcoma...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29629570/modulatory-effects-of-rosemary-leaves-aqueous-extraction-against-oxidative-stress-and-related-damages-in-experimental-model-of-ccl4-induced-cardiac-toxicity-in-mice
#17
Houda Hamed, Khaled Bellassoued, Noura Brahmi, Ahmed Gargouri, Zied Ghannoudi, Abdelfattah El Feki
Rosmarinus officialis L., Lamiaceae, has been traditionally used in Tunisia to treat several diseases. The aim of the present study is to analyze the cardiopreventive effect of Aqueous Extract of Rosemary (Rosmarinus officinalis) Leaves (AERL) against oxidative stress induced by carbon tetrachloride in experimental mice. The current study was performed on female Wistar mice divided into four groups of seven animals each. Cardiotoxity was induced by a single intraperitoneal injection of CCl4 (10ml/kg in 0.3 % olive oil) in mice which were gavaged daily with 100 mg of AERL for 15 days...
April 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29629513/postoperative-radiotherapy-is-dispensable-for-oscc-patients-with-micrometastases-in-lymph-nodes
#18
Y M Pu, Y Yang, Y J Wang, L Ding, X F Huang, Z Y Wang, Y H Ni, Q G Hu
Lymph node metastasis is a decisive factor for performing postoperative radiotherapy for oral squamous cell carcinoma (OSCC). However, whether OSCC patients with only micrometastasis need postoperative radiotherapy is unclear. In this study, OSCC patients (n = 311) with negative (n = 247), only micrometastasis (n = 44) and macrometastasis (n = 20) were detected and selected by HE staining. Micrometastasis was re-assessed using immunohistochemical staining of cytokeratin (CK) in HE-negative patients to find out the false negative cases...
April 9, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29628087/effect-of-trichoderma-viride-biofertilizer-on-ammonia-volatilization-from-an-alkaline-soil-in-northern-china
#19
Xia Wang, Shengjun Xu, Shanghua Wu, Shugeng Feng, Zhihui Bai, Guoqiang Zhuang, Xuliang Zhuang
Ammonia (NH3 ) volatilization is one of the primary pathways of nitrogen (N) loss from soils after chemical fertilizer is applied, especially from the alkaline soils in Northern China, which results in lower efficiency for chemical fertilizers. Therefore, we conducted an incubation experiment using an alkaline soil from Tianjin (pH8.37-8.43) to evaluate the suppression effect of Trichoderma viride (T. viride) biofertilizer on NH3 volatilization, and compared the differences in microbial community structure among all samples...
April 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29626517/eiris-eigen-analysis-approach-for-improved-spine-multi-shot-diffusion-mri
#20
Li Guo, Feng Huang, Zhongbiao Xu, Yingjie Mei, Wenxing Fang, Xiaodong Ma, Erpeng Dai, Hua Guo, Qianjin Feng, Wufan Chen, Yanqiu Feng
Image reconstruction using image-space sampling function (IRIS) corrects motion-induced inter-shot phase variations using phase maps from navigator-echo for multi-shot diffusion MRI. However, the bandwidth along the phase-encoding direction of navigator-echo is usually lower than that of image-echo, and thus their geometric distortions may be different. This geometric mismatch is corrected in IRIS by using the B0 map from an additional scan. In this paper, we present an enhanced IRIS (eIRIS) method that remove the requirement of B0 map...
April 4, 2018: Magnetic Resonance Imaging
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