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https://www.readbyqxmd.com/read/29768673/the-use-of-complementary-and-alternative-medicines-during-breastfeeding-results-from-the-herbal-supplements-in-breastfeeding-investigation-habit
#1
Alessandra Bettiol, Niccolò Lombardi, Ettore Marconi, Giada Crescioli, Roberto Bonaiuti, Valentina Maggini, Eugenia Gallo, Alessandro Mugelli, Fabio Firenzuoli, Claudia Ravaldi, Alfredo Vannacci
AIMS: Use of complementary and alternative medicines (CAMs) during breastfeeding is commonly increasing, mainly due to their presumed higher safety compared to conventional medications. Indeed, CAMs can cause serious adverse effects, and high-quality evidence supporting their use during lactation is limited. In Italy, specific investigations on the attitude of lactating women towards CAMs are lacking. The Herbal supplements in Breastfeeding InvesTigation (HaBIT) aimed to explore the attitudes and knowledge on CAMs among lactating women...
May 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29761830/itc-commentary-on-metformin-clinical-drug-drug-interaction-study-design-that-enables-an-efficacy-and-safety-based-dose-adjustment-decision
#2
Maciej J Zamek-Gliszczynski, Xiaoyan Chu, Jack A Cook, Joseph M Custodio, Aleksandra Galetin, Kathleen M Giacomini, Caroline A Lee, Mary F Paine, Adrian S Ray, Joseph A Ware, Matthias B Wittwer, Lei Zhang
Metformin drug-drug interaction (DDI) studies are conducted during development of drugs that inhibit organic cation transporters and/or multidrug and toxin extrusion proteins (OCTs/MATEs). Monitoring solely changes in systemic exposure, the typical DDI study endpoint appears inadequate for metformin, which is metabolically stable, has poor passive membrane permeability, and undergoes transporter-mediated tissue distribution and clearance. Evaluation of renal clearance, antihyperglycemic effects, and potentially lactate as an exploratory safety marker, can support rational metformin dose adjustment...
May 15, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29753454/response-of-a-local-hospital-to-a-burn-disaster-contributory-factors-leading-to-zero-mortality-outcomes
#3
Eng-Kean Yeong, Ciaran P O'Boyle, Hui-Fu Huang, Hao-Chih Tai, Yen-Chun Hsu, Shu-Yang Chuang, Yu-Feng Wu, Che-Wei Chang, Tom J Liu, Hong-Shiee Lai
OBJECTIVE: To investigate the outcomes of a local healthcare system in managing a burn mass casualty incident (BMCI). METHODS: Thirty-three victims admitted to the National Taiwan University Hospital within 96h of the explosion were included in the study. Data were recorded on: patient demographics, Baux score, laboratory data, management response, treatment strategies, and outcomes. Case notes from June 27, 2015 to November 2015 were reviewed with a focus on fluid resuscitation, ventilation support, nutrition, infection control, sepsis treatment, and wound closure plan...
May 9, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29753318/successful-pregnancy-in-maple-syrup-urine-disease-a-case-report-and-review-of-the-literature
#4
Sarah Catharina Grünert, Stefanie Rosenbaum-Fabian, Anke Schumann, Karl Otfried Schwab, Nadja Mingirulli, Ute Spiekerkoetter
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive disorder of branched-chain amino acid metabolism. Patients with MSUD are at risk of life-threatening metabolic decompensations with ketoacidosis and encephalopathy. These episodes are often triggered by physiological stress. Only few cases of pregnancies in MSUD mothers have been reported so far. CASE PRESENTATION: We present the favorable outcome of a pregnancy in a woman with classical MSUD...
May 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29751949/platelet-storage-lesions-what-more-do-we-know-now
#5
REVIEW
Monica Suet Ying Ng, John-Paul Tung, John Francis Fraser
Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage...
April 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29743860/ameliorative-effects-of-spirulina-platensis-against-lead-induced-nephrotoxicity-in-newborn-rats-modulation-of-oxidative-stress-and-histopathological-changes
#6
Manel Gargouri, Ahlem Soussi, Amel Akrouti, Christian Magné, Abdelfattah El Feki
Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive control, S) received a diet enriched with spirulina , group III received only lead through drinking water (Pb), and group IV received both a diet enriched with spirulina and lead contaminated water (S Pb)...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29732332/case-report-of-a-pustular-dermatitis-outbreak-in-sheep-clinical-and-food-safety-considerations
#7
Mariana Roccaro, Silvia Piva, Alessandra Scagliarini, Federica Giacometti, Andrea Serraino, Giuseppe Merialdi, Matteo Frasnelli, Angelo Romano, Alberto Bellio, Lucia Decastelli, Angelo Peli
The objective of this report is to describe an outbreak of pustular dermatitis in a flock of about 200 sheep, its clinical evolution and food safety implications. The onset of the symptoms was sudden and the lesions spread very quickly from ewe to ewe, so that in about 3 days almost all of the lactating sheep were stricken. Pustules from 5 different animals, six milk samples, two cheese samples, teat cup samples from the milking machine and farmer's hands were analysed. A pure culture of Staphylococcus aureus , producing staphylococcal enterotoxin (SE) C, was isolated from pustules...
March 31, 2018: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29719401/a-restrictive-dose-of-crystalloids-in-patients-during-laparoscopic-cholecystectomy-is-safe-and-cost-effective-prospective-two-arm-parallel-randomized-controlled-trial
#8
Matija Belavić, Vlatka Sotošek Tokmadžić, Antonija Brozović Krijan, Ines Kvaternik, Kristina Matijaš, Nedjeljko Strikić, Josip Žunić
Purpose: There are no evidence-based guidelines for volume replacement during surgical procedures such as laparoscopic cholecystectomy. However, the administration of a restrictive volume of crystalloids could be more cost-effective and safe. This trial aimed to determine the effectiveness and safety of a restrictive regimen of crystalloids in patients during laparoscopic cholecystectomy by analyzing its cost-effectiveness and 1-year morbidity rate. Patients and methods: In this randomized, prospective study, patients were assigned to one of three groups based on the volume of fluid administered: the restrictive group received 1 mL/kg/hr, the low liberal group received 5 mL/kg/hr, and the high liberal group received 15 mL/kg/hr of Ringer's solution intraoperatively...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29719312/contrast-agents-and-observing-patient-safety-programs-in-radiology-departments-in-kermanshah-province-hospitals-in-west-of-iran
#9
Fatemhe Amiri, Mohammad Rasoul Tohidnia, Somayeh Haydarizadi, Rasool Azmoonfar
Introduction: Contrast agents play an important role in increasing the efficiency of diagnostic imaging techniques in the evaluation of vascular lesions, infections and tumors. Annually more than 70 million radiology tests performed using contrast agent materials in the world. Side effects of contrast agent can belief-threaten, so that observing safety guideline prescribed a key role in the patient's health. Aim: The aim of this study was evaluation of compliance with the instructions in the use of contrast agent materials in Kermanshah province Hospitals, West in Iran...
2018: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29708295/the-safety-of-st-john-s-wort-hypericum-perforatum-in-pregnancy-and-lactation-a-systematic-review-of-rodent-studies
#10
REVIEW
Catharine Avila, Dawn Whitten, Sue Evans
Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Hence, animal studies often inform clinical decisions. The objective of this study is to systematically review rodent studies assessing the safety of SJW during the perinatal period. A literature search to November 10, 2017, identified 10 rodent studies that met a priori inclusion criteria...
April 30, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29688087/modification-of-translationally-controlled-tumor-protein-derived-protein-transduction-domain-for-improved-intranasal-delivery-of-insulin
#11
Hae-Duck Bae, Joohyun Lee, Kyu-Yeon Jun, Youngjoo Kwon, Kyunglim Lee
Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor protein (TCTP-PTD 13, MIIFRALISHKK) was reported to provide enhanced intranasal delivery of insulin. In this study, we tested whether its efficiency could be further improved by replacing amino acids in TCTP-PTD 13 or changing the amino acids in the carrier peptides from the l- to the d-form. We assessed the pharmacokinetics of PTD-mediated transmucosal delivery of insulin in normal rats and the activity of insulin in alloxan-induced diabetic rats...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29659371/real-world-use-safety-and-survival-of-ipilimumab-in-metastatic-cutaneous-melanoma-in-the-netherlands
#12
Anouk Jochems, Brenda Leeneman, Margreet G Franken, Maartje G Schouwenburg, Maureen J B Aarts, Alexander C J van Akkooi, Franchette W P J van den Berkmortel, Alfonsus J M van den Eertwegh, Gerard Groenewegen, Jan Willem B de Groot, John B A G Haanen, Geke A P Hospers, Ellen Kapiteijn, Rutger H Koornstra, Wim H J Kruit, Marieke W J Louwman, Djura Piersma, Rozemarijn S van Rijn, Albert J Ten Tije, Gerard Vreugdenhil, Michel W J M Wouters, Carin A Uyl-de Groot, Koos J M van der Hoeven
Phase III trials with ipilimumab showed an improved survival in patients with metastatic melanoma. We evaluated the use and safety of ipilimumab, and the survival of all patients with metastatic cutaneous melanoma (N=807) receiving ipilimumab in real-world clinical practice in The Netherlands using data from the Dutch Melanoma Treatment Registry. Patients who were registered between July 2012 and July 2015 were included and analyzed according to their treatment status: treatment-naive (N=344) versus previously-treated (N=463)...
April 13, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#13
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29623714/-herbs-for-increasing-breast-milk-production
#14
Zuzana Vargová, Jana Rudá Kučerová
Subjective perception of insufficient milk supply is one of the most common problems of nursing mothers. For centuries, herbs have been used to increase lactation and remain popular even today. There is only a limited number of studies proving their safety and effectivity, so their use is based primarily on previous experience. The use of certain herbs has shown that they could be effective and safe, but further research is needed to define terms of use. This paper describes preliminary findings on the mechanism of action, adverse effects and possible interactions observed in some herbs frequently used to promote lactation...
2018: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/29615835/the-effect-of-electronic-cigarette-and-tobacco-smoke-exposure-on-copd-bronchial-epithelial-cell-inflammatory-responses
#15
Andrew Higham, Declan Bostock, George Booth, Josiah V Dungwa, Dave Singh
Background: Electronic cigarettes (e-cigs) are used to help smoking cessation. However, these devices contain harmful chemicals, and there are safety concerns. We have investigated the effects of e-cigs on the inflammatory response and viability of COPD bronchial epithelial cells (BECs). Methods: BECs from COPD patients and controls were exposed to e-cig vapor extract (ECVE) and the levels of interleukin (IL)-6, C-X-C motif ligand 8 (CXCL8), and lactate dehydrogenase release were measured...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29603358/rapid-review-shows-that-probiotics-and-fermented-infant-formulas-do-not-cause-d-lactic-acidosis-in-healthy-children
#16
REVIEW
J Łukasik, S Salminen, H Szajewska
AIM: Extensive on-going research on probiotics and infant formulas raises a number of safety questions. One concern is the potential influence of D-lactic acid-containing preparations on the health of infants and children. The aim of this review was to summarise the available knowledge on the ingestion of D-lactic acid-producing bacteria, acidified infant formulas and fermented infant formulas as a potential cause of paediatric D-lactic acidosis. METHODS: A Medline database search was performed in July 2017, with no restrictions on the language, article type or publication date...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29601848/food-safety-using-nmr-based-metabolomics-assessment-of-the-atlantic-bluefin-tuna-thunnus-thynnus-from-the-mediterranean-sea
#17
Tiziana Cappello, Alessia Giannetto, Vincenzo Parrino, Giuseppe De Marco, Angela Mauceri, Maria Maisano
Seafood is a valuable component of human diet because of its nutritional properties. The Atlantic bluefin tuna Thunnus thynnus is a scombroid fish highly appreciated as seafood worldwide. Being a top pelagic predator, concerns have been raised over human health risks due to its consumption. Therefore, herein it was comprehensively evaluated the health status and potential metabolite shifts between sexes of bluefin tuna from the Mediterranean Sea, proved to bioaccumulate environmental obesogens, namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) at hepatic level...
March 27, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29597125/the-anti-inflammatory-effect-of-exogenous-lactoferrin-on-breeding-induced-endometritis-in-susceptible-mares-when-administered-post-breeding-in-susceptible-mares
#18
C E Fedorka, K E Scoggin, Y L Boakari, N E Hoppe, E L Squires, B A Ball, M H T Troedsson
The deposition of semen into the uterus of the horse induces a transient innate immune response that lasts 24-36 h in the normal mare. There exists a subset of mares that are unable to resolve this inflammation in a timely manner, and are classified as susceptible to the disease of persistent breeding-induced endometritis (PBIE). Lactoferrin is a protein of interest as a potential therapeutic for this persistent inflammation due to its anti-inflammatory and bactericidal properties. The addition of human recombinant lactoferrin (hrLF) to the insemination dose was previously shown to suppress mRNA expression of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α at 6 h after insemination, but no studies have shown the effect of lactoferrin when infused post-breeding...
March 22, 2018: Theriogenology
https://www.readbyqxmd.com/read/29572667/use-of-therapeutics-in-pregnancy-and-lactation
#19
EDITORIAL
Sara Eyal
This theme issue of Pharmaceutical Research is dedicated to drug research and therapy in pregnant and breastfeeding woman. Enthusiasm for studying drug safety and toxicity in these patients (and in their children) has risen over the past decade. Yet, the accumulation of data is slow. A combined effort of industry, regulators, academia and clinicians can promote the treatment of these populations, as discussed in detail in this issue.
March 23, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29552858/-effect-of-ophiopogonin-d-in-resisting-vascular-endothelial-cell-apoptosis-induced-by-ang%C3%A2-through-up-regulating-cyp2j2-eets
#20
Xiao-Yan Huang, Yu-Guang Wang, Yi Wang, Yue Gao
This study aimed to investigate the effect and mechanism of ophiopogonin D (OP-D) on Ang Ⅱ-induced HUVECs apoptosis, in order to provide a reliable basis for the safety and efficacy of traditional Chinese medicines. The effect of Ang Ⅱ on survival and total proteins content of HUVECs were measured by MTT and Western blotting. The effect of OP-D on Ang Ⅱ-induced lactate dehydrogenase (LDH) release rate in HUVECs was measured by enzyme standard instrument. The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang Ⅱ were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH)...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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