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https://www.readbyqxmd.com/read/29688184/-psychotropic-drugs-in-pregnancy
#1
Zsuzsa Valasinyovszki, Alexander Kancsev
According to the statistics, there is an increased number of pregnant women taking psychotropic medication. For each clinical decision, or change in therapy that affect women of reproductive age, one has to consider the available information on the reproductive safety of psychiatric drugs. Due to ethical considerations, there are no randomized, double-blind, placebo-controlled studies, hence no unequivocal evidence addressing this topic. When used during pregnancy, there might be potential adverse effects of psychotropic drugs in regards to the following: teratogenicity, pregnancy outcome, obstetrical complications, neonatal toxicity and withdrawal syndrome, breastfeeding, and the offspring's long-term intellectual, behavioral, emotional development...
2018: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/29686956/management-of-primary-mediastinal-b-cell-lymphoma-in-pregnancy
#2
Sidra Khalid, Aariez Khalid, Hamed Daw, Praful Maroo
Primary mediastinal B-cell lymphoma (PMBCL) is a subtype of non-Hodgkin's lymphoma, which occurs rarely in pregnancy. We present a case of a pregnant 22-year-old female who presented with syncope and dyspnea. Computed tomography (CT) chest showed an anterior mediastinal mass, and its biopsy showed PMBCL. Since she was in her second trimester, we decided to treat her with rituximab-cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP). Our case emphasizes the safety of chemotherapy in the second and third trimesters, with good maternal and fetal outcomes...
February 21, 2018: Curēus
https://www.readbyqxmd.com/read/29684258/reduction-of-peripartum-racial-and-ethnic-disparities-a-conceptual-framework-and-maternal-safety-consensus-bundle
#3
Elizabeth A Howell, Haywood Brown, Jessica Brumley, Allison S Bryant, Aaron B Caughey, Andria M Cornell, Jacqueline H Grant, Kimberly D Gregory, Susan M Gullo, Katy B Kozhimannil, Jill M Mhyre, Paloma Toledo, Robyn D'Oria, Martha Ngoh, William A Grobman
Racial and ethnic disparities exist in both perinatal outcomes and health care quality. For example, black women are 3 to 4 times more likely to die from pregnancy-related causes and have more than a 2-fold greater risk of severe maternal morbidity than white women. In an effort to achieve health equity in maternal morbidity and mortality, a multidisciplinary workgroup of the National Partnership for Maternal Safety, within the Council on Patient Safety in Women's Health Care, developed a concept article for the bundle on reduction of peripartum disparities...
April 23, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29684104/maternal-vitamin-d-supplementation-during-pregnancy
#4
Elizabeth M Curtis, Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
Introduction: Maternal vitamin D status in pregnancy has been linked to many health outcomes in mother and offspring. A wealth of observational studies have reported on both obstetric outcomes and complications, including pre-eclampsia, gestational diabetes, mode and timing of delivery. Many foetal and childhood outcomes are also linked to vitamin D status, including measures of foetal size, body composition and skeletal mineralization, in addition to later childhood outcomes, such as asthma...
April 19, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29683910/acog-committee-opinion-no-735-adolescents-and-long-acting-reversible-contraception-implants-and-intrauterine-devices
#5
(no author information available yet)
The phenomenon of adolescent childbearing is complex and far reaching, affecting not only the adolescents but also their children and their community. The prevalence and public health effect of adolescent pregnancy reflect complex structural social problems and an unmet need for acceptable and effective contraceptive methods in this population. In 2006-2010, 82% of adolescents at risk of unintended pregnancy were currently using contraception, but only 59% used a highly effective method, including any hormonal method or intrauterine device...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683905/acog-committee-opinion-no-735-summary-adolescents-and-long-acting-reversible-contraception-implants-and-intrauterine-devices
#6
(no author information available yet)
The phenomenon of adolescent childbearing is complex and far reaching, affecting not only the adolescents but also their children and their community. The prevalence and public health effect of adolescent pregnancy reflect complex structural social problems and an unmet need for acceptable and effective contraceptive methods in this population. In 2006-2010, 82% of adolescents at risk of unintended pregnancy were currently using contraception, but only 59% used a highly effective method, including any hormonal method or intrauterine device...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683895/reduction-of-peripartum-racial-and-ethnic-disparities-a-conceptual-framework-and-maternal-safety-consensus-bundle
#7
Elizabeth A Howell, Haywood Brown, Jessica Brumley, Allison S Bryant, Aaron B Caughey, Andria M Cornell, Jacqueline H Grant, Kimberly D Gregory, Susan M Gullo, Katy B Kozhimannil, Jill M Mhyre, Paloma Toledo, Robyn DʼOria, Martha Ngoh, William A Grobman
Racial and ethnic disparities exist in both perinatal outcomes and health care quality. For example, black women are three to four times more likely to die from pregnancy-related causes and have more than a twofold greater risk of severe maternal morbidity than white women. In an effort to achieve health equity in maternal morbidity and mortality, a multidisciplinary workgroup of the National Partnership for Maternal Safety, within the Council on Patient Safety in Women's Health Care, developed a concept article for the bundle on reduction of peripartum disparities...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29682297/safety-and-pharmacokinetics-of-dolutegravir-in-hiv-positive-pregnant-women-a-systematic-review
#8
EDITORIAL
Andrew Hill, Polly Clayden, Claire Thorne, Rachel Christie, Rebecca Zash
Background: The integrase strand transfer inhibitor dolutegravir (DTG) is being introduced into low- and middle-income countries (LMICs) as an alternative to first-line treatment with non-nucleoside reverse transcriptase inhibitors. However, DTG is not yet widely recommended for use in pregnant women. The aim of this systematic review was to analyse all available data on birth outcomes and congenital anomalies in the infants of pregnant women treated with DTG. Methods: A PubMed and Embase search was conducted using the terms "dolutegravir" or "DTG" and "pregnancy" or "pregnant" from the earliest available date on the database to 26 July 2017...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681712/effectiveness-of-anti-mullerian-hormone-tailored-protocol-compared-to-conventional-protocol-in-women-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#9
Sumi Thomas, Mousumi Acharya, K Muthukumar, Achamma Chandy, Mohan S Kamath, T K Aleyamma
Background: Assessment of ovarian reserve before an in vitro fertilization cycle (IVF) is one among the many factors that predicts a successful cycle. Individualized protocol based on ovarian reserve is designed to optimize the pregnancy outcome without compromising the patient safety. Although authors have shown that anti-Mullerian hormone-tailored (AMH) protocols have reduced the treatment burden and improved pregnancy rates, a few others have questioned its efficacy. Aims: The aim of this study was to decide whether the AMH-tailored protocol or the conventional protocol better decides IVF outcomes...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29679622/pharmacotherapy-for-hyperglycemia-in-pregnancy-do-oral-agents-have-a-place
#10
REVIEW
Rosa Corcoy, Montserrat Balsells, Apolonia García-Patterson, Anat Shmueli, Eran Hadar
Diabetes is a frequent condition in pregnancy and achieving adequate glycemic control is of paramount importance. Insulin treatment is the gold standard, oral agents are more attractive, but their safety and efficiency should be a prerequisite for their use. We have more information regarding treatment of women with gestational diabetes mellitus where glyburide can induce a picture of fetal hyperinsulinism (higher birthweight and more neonatal hypoglycemia) whereas metformin requires supplemental insulin in a larger proportion of women but achieves satisfactory perinatal outcomes with the exception of preterm birth...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679590/phase-i-ii-pharmacokinetic-and-pharmacodynamic-evaluation-of-two-levonorgestrel-only-contraceptive-patches-in-a-multicenter-randomized-trial
#11
Carolyn L Westhoff, Beatrice A Chen, Jeffrey T Jensen, Kurt Barnhart, Michael Thomas, Stephanie Teal, Diana Blithe
OBJECTIVES: To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN: This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; randomization was stratified by body mass index (BMI) <32 or 32-40kg/m2 . Evaluations occurred twice weekly for 5weeks, then once weekly with supplemental visits for participants reporting a urinary LH surge...
April 18, 2018: Contraception
https://www.readbyqxmd.com/read/29676935/current-and-emerging-two-drug-approaches-for-hiv-1-therapy-in-art-na%C3%A3-ve-and-art-experienced-virologically-suppressed-patients
#12
Barbara Rossetti, Francesca Montagnani, Andrea De Luca
Current guidelines recommend a 2-drug antiretroviral regimen as an alternative to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and costs. Areas covered: This review is intended to provide insight into the efficacy, safety and tolerability of 2-drug versus 3-drug ART in naïve and in treatment-experienced virologically-suppressed patients. Expert opinion: Dual therapy regimens are not feasible in HBV-coinfected individuals and should not be applied during pregnancy. Positive data on 2-drug ART in drug naïve patients are still limited, while, in virologically-suppressed individuals, several regimens have shown non-inferiority as compared to 3-drug regimens...
April 20, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29676634/impact-of-seasonal-winter-air-pollution-on-health-across-the-lifespan-in-mongolia-and-some-putative-solutions
#13
David Warburton, Nicole Warburton, Clarence Wigfall, Ochir Chimedsuren, Delgerzul Lodoisamba, Sereeter Lodoysamba, Badarch Jargalsaikhan
Environmental pollution of the air, water, and soil comprise an increasingly urgent challenge to global health, well-being, and productivity. The impact of environmental pollution arguably has its greatest impact across the lifespan on children, women of childbearing age, and pregnant women and their unborn children, not only because of their vulnerability during development, but also because of their subsequent longevity. Ulaanbaatar, Mongolia, is a highly instructive, perhaps extreme, example of what happens with recent, rapid urbanization...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29674762/current-multidisciplinary-approach-to-fertility-preservation-for-breast-cancer-patients
#14
Yuko Takahashi, Tadahiko Shien, Ai Sakamoto, Yuko Tsuyumu, Ryo Yoshioka, Maya Uno, Minami Hatono, Mariko Kochi, Kengo Kawada, Takahiro Tsukioki, Takayuki Iwamoto, Hirokuni Ikeda, Naruto Taira, Junji Matsuoka, Mikiya Nakatsuka, Hiroyoshi Doihara
Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674237/eslicarbazepine-acetate-exposure-in-pregnant-women-with-epilepsy
#15
Raquel Costa, Luís M Magalhães, Joana Graça, Mariana Vieira, Helena Gama, Joana Moreira, José F Rocha, Patrício Soares-da-Silva
PURPOSE: Epilepsy is a common neurologic disorder requiring continued treatment during pregnancy. Treatment with antiepileptic drugs (AEDs) is needed for seizure control, but the risk of adverse events has to be minimized for both mother and foetus. Available data on pregnancy and foetal/postnatal outcomes following eslicarbazepine acetate (ESL) exposure via parent is herein presented for the first time. METHODS: ESL's global safety database was reviewed to identify pregnancy cases with exposure to ESL reported up to October 21st, 2017...
April 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29673659/effect-of-epidural-anesthesia-in-labor-pregnancy-with-cardiovascular-disease
#16
Hiroaki Tanaka, Chizuko Kamiya, Shinji Katsuragi, Kayo Tanaka, Jun Yoshimatsu, Tomoaki Ikeda
OBJECTIVE: We studied the effect and safety of epidural anesthesia during labor in pregnant women with cardiovascular disease. MATERIALS AND METHODS: In the pregnant women with cardiovascular disease, we compared maternal outcome and suppressive effect on blood pressure retrospectively between the epidural group (anesthetized epidurally during labor) and the no-epidural group (not anesthetized epidurally during labor). RESULTS: A total of 277 patients were included in the analyses...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673302/disjunctures-in-experiences-of-support-during-the-transition-to-fatherhood-of-men-who-have-used-intimate-partner-violence
#17
Juliana Carlson, Erin Casey
The transition to fatherhood has been shown to be a stressful time for men, and their experiences of identifying and accessing formal and informal support are mixed. However, research on the experience of men who use intimate partner violence (IPV) during the transition to fatherhood is limited. The evidence documenting the prevalence and short- and long-term impact of violence perpetrated by men against women during pregnancy and postpartum demonstrates the seriousness of this public health issue. To understand the mechanisms of interrupting IPV by engaging men, the gap between what is known about experiences of identifying the need for and access to support during the transition to fatherhood of men with past and current histories of using IPV must be bridged...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29669596/misoprostol-administered-sublingually-at-a-dose-of-12-5-%C3%AE-g-versus-vaginally-at-a-dose-of-25-%C3%AE-g-for-the-induction-of-full-term-labor-a-randomized-controlled-trial-protocol
#18
Daniele Sofia Moraes Barros Gattás, José Roberto da Silva Junior, Alex Sandro Rolland Souza, Francisco Edson Feitosa, Melania Maria Ramos de Amorim
BACKGROUND: Various methods are currently used for the induction of labor. Nevertheless, the most effective method with the fewest side effects remains to be established. Misoprostol, administered vaginally, has been routinely used for this purpose; however, other forms of administration are being proposed, including the use of sublingual tablets. No studies have yet compared the effectiveness and safety of 12.5-μg misoprostol administered sublingually compared to a 25-μg vaginal dose of the drug for the induction of labor...
April 18, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29669335/antenatal-corticosteroid-exposure-disrupts-myelination-in-the-auditory-nerve-of-preterm-sheep
#19
Judith Rittenschober-Böhm, Jennifer Rodger, Alan H Jobe, Suhas G Kallapur, Dorota A Doherty, Boris W Kramer, Matthew S Payne, Michael Archer, Christian Rittenschober, John P Newnham, Yuichiro Miura, Angelika Berger, Stephen G Matthews, Matthew W Kemp
BACKGROUND: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for the developing fetus, particularly its neurosensory development. OBJECTIVES: We investigated the effect of single and multiple ACS exposures on auditory nerve development in an ovine model of pregnancy. METHODS: Ewes with a single fetus (gestational age [GA] 100 days) received an intramuscular injection of 150 mg medroxyprogesterone-acetate, followed by intramuscular (i) betamethasone (0...
April 17, 2018: Neonatology
https://www.readbyqxmd.com/read/29664907/what-matters-to-women-during-childbirth-a-systematic-qualitative-review
#20
Soo Downe, Kenneth Finlayson, Olufemi Oladapo, Mercedes Bonet, A Metin Gülmezoglu
INTRODUCTION: Design and provision of good quality maternity care should incorporate what matters to childbearing women. This qualitative systematic review was undertaken to inform WHO intrapartum guidelines. METHODS: Using a pre-determined search strategy, we searched Medline, CINAHL, PsycINFO, AMED, EMBASE, LILACS, AJOL, and reference lists of eligible studies published 1996-August 2016 (updated to January 2018), reporting qualitative data on womens' childbirth beliefs, expectations, and values...
2018: PloS One
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