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https://www.readbyqxmd.com/read/28110471/depletion-of-mitofusin-2-causes-mitochondrial-damage-in-cisplatin-induced-neuropathy
#1
Ilja Bobylev, Abhijeet R Joshi, Mohammed Barham, Wolfram F Neiss, Helmar C Lehmann
Sensory neuropathy is a relevant side effect of the antineoplastic agent cisplatin. Mitochondrial damage is assumed to play a critical role in cisplatin-induced peripheral neuropathy, but the pathomechanisms underlying cisplatin-induced mitotoxicity and neurodegeneration are incompletely understood. In an animal model of cisplatin-induced neuropathy, we determined in detail the extent and spatial distribution of mitochondrial damage during cisplatin treatment. Changes in the total number of axonal mitochondria during cisplatin treatment were assessed in intercostal nerves from transgenic mice that express cyan fluorescent protein...
January 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28110419/patients-trust-in-physician-patient-enablement-and-health-related-quality-of-life-during-colon-cancer-treatment
#2
Nicole Ernstmann, Markus Wirtz, Anika Nitzsche, Sophie E Gross, Lena Ansmann, Tristan D Gloede, Julia Jung, Holger Pfaff, Walter Baumann, Stephan Schmitz, Melanie Neumann
In cancer care, where patients and their families experience significant emotional distress and patients have to deal with complex medical information, patient centeredness is an important aspect of quality of care. The aim of this study is to examine the impact of patients' trust in their oncologists and patients' enablement on changes in health-related quality of life of colon cancer patients during follow-up care. We conducted a prospective study in a representative sample of private practices of German oncologists (N = 44)...
January 21, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28110377/sulfasalazine-in-prevention-of-pouchitis-after-proctocolectomy-with-ileal-pouch-anal-anastomosis-for-ulcerative-colitis
#3
Eleonora Scaioli, Alessandro Sartini, Elisa Liverani, Richard John Digby, Giampaolo Ugolini, Giancarlo Rosati, Gilberto Poggioli, Davide Festi, Franco Bazzoli, Andrea Belluzzi
BACKGROUND: Pouchitis is the most frequent complication after ileal pouch-anal anastomosis for refractory ulcerative colitis. A non-standardized preventative treatment exists. Sulfasalazine has proved effective in acute pouchitis therapy. AIMS: The aim of this study was to retrospectively evaluate the effect of sulfasalazine in primary prophylaxis of pouchitis after proctocolectomy with ileal pouch-anal anastomosis. METHODS: Data files of patients who underwent total proctocolectomy with ileal pouch-anal anastomosis for refractory ulcerative colitis and/or dysplasia from January 2007 to December 2014, with a follow-up until August 2015, were analyzed...
January 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28110265/comparative-effectiveness-of-two-disparate-policies-on-child-health-experimental-evidence-from-the-philippines
#4
John W Peabody, Stella Quimbo, Jhiedon Florentino, Riti Shimkhada, Xylee Javier, David Paculdo, Dean Jamison, Orville Solon
BACKGROUND  : Should health systems invest more in access to care by expanding insurance coverage or in health care services including improving the quality of care? Comparing these options experimentally would shed light on the impact and cost-effectiveness of these strategies. METHODS  : The Quality Improvement Demonstration Study (QIDS) was a randomized policy experiment conducted across 30 districts in the Philippines. The study had a control group and two policy intervention groups intended to improve the health of young children...
January 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28110176/the-management-of-hiv-in-pregnancy-a-10-year-experience
#5
Sonia F Raffe, Charlotte Savage, Louisa A Perry, Amie Patel, Tricia Keith, Richard Howell, Robert Bradley, Rob Bomont, Katy Fidler, Yvonne Gilleece
OBJECTIVE: The package of care to reduce HIV mother to child transmission (MTCT) has evolved significantly since trials of ante and intrapartum antiretroviral therapy (ART) in 1994. In the UK MTCT rate has fallen from 25.6% in the 1990s to 0.46%. We review the management of HIV in pregnancy in Brighton in the context of evolving guidelines. STUDY DESIGN: HIV, obstetric and neonatal notes of all HIV positive women, pregnant between 2003 and 2014, were reviewed. RESULTS: 97 pregnancies in 75 women were identified, resulting in 79 live births...
January 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28110175/ketogenic-diet-therapy-for-epilepsy-during-pregnancy-a-case-series
#6
Elles J T M van der Louw, Tanya J Williams, Bobbie J Henry-Barron, Joanne F Olieman, Johannes J Duvekot, Marijn J Vermeulen, Natalja Bannink, Monique Williams, Rinze F Neuteboom, Eric H Kossoff, Coriene E Catsman-Berrevoets, Mackenzie C Cervenka
PURPOSE: Evaluation of ketogenic diet (KD) therapies for seizure control during pregnancy when safety and appropriate management become considerations. Until now, no information has been available on seizure reduction and human pregnancy related outcomes in women treated with KD therapies. METHOD: We describe two cases of pregnant women with epilepsy treated with KD therapy either as monotherapy (Case 1) or as adjunctive therapy (Case 2). RESULTS: Case 1: A 27 year old woman, gravida1, started the classic KD with medium chain triglyceride (MCT) emulsion and 75g carbohydrate-restriction, later reduced to 47g...
December 26, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28110173/tuning-physical-properties-and-bmp-2-release-rates-of-injectable-hydrogel-systems-for-an-optimal-bone-regeneration-effect
#7
Bo-Bae Seo, Jeong-Tae Koh, Soo-Chang Song
For a substance to be used as a drug delivery carrier and tissue inducible material for a target disease, its drug release rate and physical properties should be optimized to facilitate the healing process. We developed multi-tunable hydrogel systems with various physical properties and release behaviors to determine the optimal conditions for bone regeneration. Five injectable poly(phosphazene) hydrogels were developed with different types and amounts of anionic side-chains. The five polymer hydrogels showed considerably different in vitro and in vivo performances for sol-gel phase transition, dissolution/degradation, water uptake, and pore size...
January 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28110165/pulling-a-school-trolley-a-good-kinematic-option-for-children
#8
Eva Orantes-Gonzalez, Jose Heredia-Jimenez
This study analyzed the kinematic gait parameters associated with pulling a school trolley with different loads and the effects of the type of packing device user (backpack vs. trolley) and body side (loadedunloaded). Methods Fifty-three elementary subjects walked at a selfselected speed under four experimental conditions: without a trolley and pulling a trolley with 10%, 15% and 20% of the subject́s body weight (BW). Averages and standard deviations of spatiotemporal gait parameters and 3D kinematics of the lower limbs and thorax were obtained for the loaded and unloaded sides of the body...
January 15, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28110150/enhanced-degradation-of-iopamidol-by-peroxymonosulfate-catalyzed-by-two-pipe-corrosion-products-cuo-and-%C3%AE-mno2
#9
Jun Hu, Huiyu Dong, Jiuhui Qu, Zhimin Qiang
Peroxymonosulfate (PMS) is a promising alternative for drinking water disinfection; also many organic micropollutants may be present in drinking water sources nowadays. However, pipe corrosion products (PCPs) may impact the reactions between a disinfectant and organic micropollutants in water distribution systems. This study investigated iopamidol (IPM) degradation by PMS under catalysis of two PCPs (i.e., CuO and δ-MnO2). The pseudo-first-order rate constant of IPM degradation in the CuO/PMS system (CuPS) was 3...
January 16, 2017: Water Research
https://www.readbyqxmd.com/read/28110055/adverse-and-hypersensitivity-reactions-to-prescription-nonsteroidal-anti-inflammatory-agents-in-a-large-health-care-system
#10
Kimberly G Blumenthal, Kenneth H Lai, Mingshu Huang, Zachary S Wallace, Paige G Wickner, Li Zhou
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medications in the United States. NSAID use can be limited by adverse drug reactions (ADRs), including hypersensitivity reactions (HSRs). OBJECTIVE: We aimed to use electronic health record data to determine the incidence and predictors of HSRs to prescription NSAIDs. METHODS: We performed a retrospective cohort study of all adult outpatients in a large health care system prescribed diclofenac, indomethacin, nabumetone, or piroxicam between January 1, 2004, and September 30, 2012...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28110025/do-the-complications-increased-in-the-anterolateral-right-side-approach-to-treat-the-cervical-degenerative-disorders
#11
Zhaoyu Ba, Fumin Pan, Xiaoming Liu, Jianguang Zhu, Desheng Wu
The dysphagia and recurrent laryngeal nerve (RLN) palsy are the most common complications of the patients who underwent anterior cervical surgery in the current literature. These morbidities have led to the study of the impact of sidedness in anterior cervical spine surgery. However, many reports documented the left-side was more effective and safe than right-side based on the anatomy. So the right-side approach is more challenging. We retrospectively study 503 patients with cervical degenerative diseases who underwent cervical spinal surgery using anterolateral right-side approach in our spine center from September 1999 to December 2012 and evaluate the efficient and safety of the anterolateral right-side approach to treat the cervical degenerative diseases...
January 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28109989/low-glycemic-index-treatment-for-seizure-control-in-angelman-syndrome-a-case-series-from-the-center-for-dietary-therapy-of-epilepsy-at-the-massachusetts-general-hospital
#12
Olivia R Grocott, Katherine S Herrington, Heidi H Pfeifer, Elizabeth A Thiele, Ronald L Thibert
The low glycemic index treatment, a dietary therapy that focuses on glycemic index and reduced carbohydrate intake, has been successful in reducing seizure frequency in the general epilepsy population. Epilepsy is a common feature of Angelman syndrome and seizures are often refractory to multiple medications, especially in those with maternal deletions. Dietary therapy has become a more frequently used option for treating epilepsy, often in combination with other antiepileptic drugs, due to its efficacy and favorable side effect profile...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109949/positional-isomers-of-bispyridine-benzene-derivatives-induce-efficacy-changes-on-mglu5-negative-allosteric-modulation
#13
Xavier Gómez-Santacana, James A R Dalton, Xavier Rovira, Jean Philippe Pin, Cyril Goudet, Pau Gorostiza, Jesús Giraldo, Amadeu Llebaria
Modulation of metabotropic glutamate receptor 5 (mGlu5) with partial allosteric antagonists has received increased interest due to their favourable in vivo activity profiles compared to the unfavourable side-effects of full inverse agonists. Here we report on a series of bispyridine benzene derivatives with a functional molecular switch affecting antagonistic efficacy, shifting from inverse agonism to partial antagonism with only a single change in the substitution pattern of the benzene ring. These efficacy changes are explained through computational docking, revealing two different receptor conformations of different energetic stability and different positional isomer binding preferences...
January 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28109665/a-randomized-double-blind-comparison-of-the-efficacy-and-safety-of-low-dose-olanzapine-plus-low-dose-trifluoperazine-versus-full-dose-olanzapine-in-the-acute-treatment-of-schizophrenia
#14
Ching-Hua Lin, Fu-Chiang Wang, Shih-Chi Lin, Yu-Hui Huang, Cheng-Chung Chen
OBJECTIVE: Antipsychotic polypharmacy is common in clinical practice, but not recommended in guidelines for treating schizophrenia patients. This study aimed to compare the efficacy and safety of low-dose olanzapine plus low-dose trifluoperazine (a first-generation antipsychotic [FGA]) to full-dose olanzapine (a second-generation antipsychotic [SGA]) in the treatment of acute schizophrenia. METHOD: In this 6-week, double-blind, fixed-dose study, patients were randomized to receive 5mg/day of olanzapine plus 5mg/day of trifluoperazine or 10mg/day of olanzapine for 6weeks...
January 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28109591/udder-firmness-as-a-possible-indicator-for-clinical-mastitis
#15
A Rees, C Fischer-Tenhagen, W Heuwieser
Swelling of the mammary gland is an important sign to detect clinical mastitis (CM) in dairy cows. The overall objective of this study was to evaluate if udder firmness can be used as a cow-side indicator for mastitis and to evaluate how CM affects firmness within 14 d after diagnosis. A dynamometer was used to objectively determine udder firmness before and after milking in 45 cows with CM and 95 healthy cows. Udder firmness of both hind quarters was measured daily on 3 locations (upper, middle, lower measuring point) from the day of mastitis diagnosis until d 7 and again on d 14...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109570/osteopathic-manipulative-treatment-improves-heart-surgery-outcomes-a-randomized-controlled-trial
#16
Vittorio Racca, Bruno Bordoni, Paolo Castiglioni, Maddalena Modica, Maurizio Ferratini
BACKGROUND: Controlling sternal pain after heart surgery is important to reduce the risk of postoperative complications, but pain is often undertreated because of contraindications and side effects of analgesic drugs. Recently, osteopathic manipulative treatment (OMT) was demonstrated to reduce pain in different clinical contexts, suggesting its potential utility after cardiac surgery. The aim of this open-label, controlled study is to assess whether OMT contributes to sternal pain relief and improves postoperative outcomes...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109267/the-use-of-physical-restraints-in-long-term-care-in-spain-a-multi-center-cross-sectional-study
#17
Gabriel J Estévez-Guerra, Emilio Fariña-López, Eduardo Núñez-González, Manuel Gandoy-Crego, Fernando Calvo-Francés, Elizabeth A Capezuti
BACKGROUND: Physical restraint is a procedure used frequently in long-term care. It is a controversial practice because its use is associated with numerous complications and also affects freedom and individual autonomy. The objective of this study was to examine the use of physical restraint of long-term care residents with the ability to move voluntarily. METHODS: We conducted a cross-sectional observational and correlational multi-center study. Nine centers agreed to participate...
January 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28109247/effectiveness-and-cost-effectiveness-of-a-guided-internet-and-mobile-based-intervention-for-the-indicated-prevention-of-major-depression-in-patients-with-chronic-back-pain-study-protocol-of-the-prod-bp-multicenter-pragmatic-rct
#18
L Sander, S Paganini, J Lin, S Schlicker, D D Ebert, C Buntrock, H Baumeister
BACKGROUND: Reducing the disease burden of major depressive disorder (MDD) is of major public health relevance. The prevention of depression is regarded as one possible approach to reach this goal. People with multiple risk factors for MDD such as chronic back pain and subthreshold depressive symptoms may benefit most from preventive measures. The Internet as intervention setting allows for scaling up preventive interventions on a public mental health level. METHODS: This study is a multicenter pragmatic randomized controlled trial (RCT) of parallel design aiming to investigate the (cost-) effectiveness of an Internet- and mobile-based intervention (IMI) for the prevention of depression in chronic back pain patients (PROD-BP) with subthreshold depressive symptoms...
January 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28109192/prevalence-of-oral-manifestations-in-children-and-adolescents-with-cancer-submitted-to-chemotherapy
#19
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
January 20, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#20
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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