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Obstructive salivary gland disease

K Möller, N Kohles, D Eßer
Salivary gland surgery is a common procedure in otorhinolaryngology. Parotidectomy and submandibulectomy represent the treatment of choice in benign and malignant tumors of the salivary glands. However, as to this point there are no guidelines are concerning diagnostic and therapeutic approaches of benign and malignant tumors of the salivary gland. Since the introduction of sialendoscopy there are new diagnostic and therapeutic procedures available in treating obstructive sialadenitis. The present article provides an overview of anatomical principles, diagnostic approaches and the most important salivary gland surgeries for future otorhinolaryngologists under specialist training...
October 2016: Laryngo- Rhino- Otologie
Vinciane Saint-Criq, Michael A Gray
Salt and fluid absorption and secretion are two processes that are fundamental to epithelial function and whole body fluid homeostasis, and as such are tightly regulated in epithelial tissues. The CFTR anion channel plays a major role in regulating both secretion and absorption in a diverse range of epithelial tissues, including the airways, the GI and reproductive tracts, sweat and salivary glands. It is not surprising then that defects in CFTR function are linked to disease, including life-threatening secretory diarrhoeas, such as cholera, as well as the inherited disease, cystic fibrosis (CF), one of the most common life-limiting genetic diseases in Caucasian populations...
October 6, 2016: Cellular and Molecular Life Sciences: CMLS
Elise A Delagnes, Annick Aubin-Pouliot, Melissa Zheng, Jolie L Chang, William R Ryan
OBJECTIVES: To prospectively assess symptoms before and after sialendoscopy-assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis without sialolithiasis. STUDY DESIGN: Prospective cohort study. METHODS: Patients with chronic obstructive sialadenitis without sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS and 3 months postoperatively. RESULTS: Of 80 consecutive patients in a 20-month period, 20 surveyed patients underwent SASDS for COSWS in 37 symptomatic glands...
October 4, 2016: Laryngoscope
Kamichika Hayashi, Takeshi Onda, Hitoshi Ohata, Nobuo Takano, Takahiko Shibahara
Here we report a case of Kussmaul's disease, or sialodochitis fibrinosa. This rare disease is characterized by recurrent swelling of the salivary glands, which then discharge clots of fibrin into the oral cavity. An 80-year-old man with a history of allergic rhinitis visited our department with the chief complaint of pain in the bilateral parotid gland area on eating. An initial examination revealed mild swelling and tenderness in this region, and indurations could be felt around the bilateral parotid papillae...
2016: Bulletin of Tokyo Dental College
Mosaad Abdel-Aziz, Badawy Khalifa, Ahmed Nassar, Ahmed Kamel, Nader Naguib, Abdel-Rahman El-Tahan
OBJECTIVE: Mucus retention cyst of the hard palate may result from obstruction of the ducts of the minor salivary glands, and it was defined as a mucocele. Although, the disease is not common in the hard palate, it was previously reported by many authors in the soft palate. The aim of our study was to present pediatric patients who were diagnosed to have mucocele of the hard palate, and to evaluate the outcome of the surgical excision of this lesion. METHODS: This is a case series study included 8 pediatric patients who presented with cystic lesions on the hard palate which were removed surgically, and were diagnosed as mucoceles...
June 2016: International Journal of Pediatric Otorhinolaryngology
Tomasz Kopeć, Małgorzata Wierzbicka, Jarosław Kałużny, Anna Młodkowska, Witold Szyfter
We present the results of treatment of sialolithiasis of the submandibular and parotid glands using sialendoscopy and sialendoscopy-assisted surgery. Between 2009-2013, 397 consecutive patients (mean (range) age 48 (18-76) years) were treated for obstructive diseases of the major salivary glands (sialolithiasis n=239, 175 submandibular and 64 parotid). In a total of 175 patients with 191 stones in the submandibular gland treated by endoscopic retrieval or surgical release, 149 patients (85%) were rendered free of stones (by sialendoscopy alone n=82, and sialendoscopy with operation n=67) Twenty patients (11%) had residual stones and 6 patients (4%) required excisionof the gland...
September 2016: British Journal of Oral & Maxillofacial Surgery
B Hofauer, A Chaker, T Strenger, M Bas, N Mansour, A Knopf
Swelling of single or multiple major salivary glands can be caused by various local or systemic diseases. In differential diagnosis, congenital cystic or vascular malformations should be considered, as well as infectious or tumorous alterations. Salivary duct obstructions due to sialolithiasis or stenosis can cause salivary gland enlargement. Multiple systemic diseases can have manifestations in the parotid or submandibular glands. As therapy varies from cause to cause, knowledge of the different potential diagnoses is crucial...
May 2016: HNO
Patrick J Bradley, Robert L Ferris
Malignant sublingual gland neoplasms are rare, early-stage neoplasms presenting as painless non-ulcerated masses in the antero-lateral floor of the mouth. The majority of patients present with advanced disease, with symptoms of pain or anaesthesia of the tongue. Malignant minor salivary gland neoplasms are more common, the majority (>80%) of which present in the oral cavity, most frequently in the palatal area, as painless masses or as obstructive symptoms in the head and neck region. The most frequent pathologies are adenoid cystic carcinoma and mucoepidermoid carcinoma (>85%), with the majority presenting at an advanced stage (III/IV)...
2016: Advances in Oto-rhino-laryngology
Annick Aubin-Pouliot, Elise A Delagnes, Jolie L Chang, William R Ryan
OBJECTIVES/HYPOTHESIS: To prospectively assess symptoms of obstructive sialadenitis before and after sialendoscopy-assisted salivary duct surgery (SASDS) using the chronic obstructive sialadenitis symptoms (COSS) questionnaire to determine and predict impact of interventions. STUDY DESIGN: Prospective cohort study. METHODS: Adult patients with chronic obstructive sialadenitis who underwent SASDS were asked to complete the COSS questionnaire and the Short-Form-8 (SF-8) quality-of-life (QOL) survey prior to surgery and 3 months postoperatively...
June 2016: Laryngoscope
Xiaoxia Ying, Jianan Kang, Fuyin Zhang, Hui Dong
Sialolithiasis is a common disease that is characterized by the obstruction of the salivary gland. Sialolithiasis mainly affects the submandibular glands and the Wharton's duct. However, bilateral sialolithiasis is a rare condition. In addition, recurrence of sialoliths subsequent to surgical excision of the submandibular gland for the treatment of sialolithiasis has been rarely reported. The present study reported a case presenting with recurrent sialoliths with sialadenitis in the residual Wharton's duct following the excision of bilateral submandibular glands...
January 2016: Experimental and Therapeutic Medicine
Takayoshi Yamamoto, Takahiro Nakajima, Hidemi Suzuki, Tetsuzo Tagawa, Takekazu Iwata, Teruaki Mizobuchi, Shigetoshi Yoshida, Yukio Nakatani, Ichiro Yoshino
BACKGROUND: Pulmonary mucoepidermoid carcinoma is a rare salivary gland-type neoplasm. We aimed to elucidate the optimal management of this rare condition by reviewing the treatment outcomes of patients at our institution with mucoepidermoid carcinoma of the lung. METHODS: We performed a retrospective review of all patients with pulmonary mucoepidermoid carcinoma who underwent surgical treatment between January 1993 and December 2012. We reviewed the patients' clinical characteristics and the therapeutic interventions undertaken...
March 2016: Asian Cardiovascular & Thoracic Annals
P Farneti, G Macrì, G Gramellini, M Ghirelli, F Tesei, E Pasquini
Sialendoscopy is a new diagnostic and surgical tool for management of salivary gland diseases that offers the opportunity to treat selected pathologies less invasively and with better results compared to previous techniques. As with any new technique, an adequate training programme involving a gradual learning curve is mandatory to quickly obtain results similar to those reported in the literature. This includes an appropriate diagnostic programme, correct patient selection and knowledge of possible pitfalls...
October 2015: Acta Otorhinolaryngologica Italica
Hideoki Yokouchi, Masaki Miyazaki, Takeaki Miyamoto, Takafumi Minami, Fumio Tsuji, Kohei Murata, Kazuhito Ohishi
Mucoepidermoid carcinoma (MEC) of the lungs is a rare type of lung cancer, mainly arising from the submucosal salivary type mucous glands of the large bronchi. MEC is classified into low- and high-grade subtypes based on its cytological and histological features, and this classification correlates well with prognosis. We report the case of a 36-year-old man diagnosed after an initial episode of obstructive pneumonia. CT and bronchoscopy revealed an endobronchial mass in the right S3 bronchus and distal atelectasis...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Gaurav Kataria, Aditi Saxena, Sanjeev Bhagat, Baldev Singh, Manpreet Kaur, Gurpreet Kaur
INTRODUCTION: Deep neck space infections (DNSI) are serious diseases that involve several spaces in the neck. The common primary sources of DNSI are dental infections, tonsillar and salivary gland infections, malignancies, and foreign bodies. With widespread use of antibiotics, the prevalence of DNSI has been reduced. Common complications of DNSI include airway obstruction, jugular vein thrombosis, and sepsis. Treatment principally comprises airway management, antibiotic therapy, and surgical intervention...
July 2015: Iranian Journal of Otorhinolaryngology
Hossein Shahoon, Sareh Farhadi, Roya Hamedi
Sialolithiasis is a common disease of the major salivary glands, characterized by the obstruction of a salivary gland or its excretory duct due to the formation of calcareous concretions. Sialoliths usually measure from 1 mm to <10 mm. They rarely measure more than 15 mm, and infrequently giant salivary gland calculi >15 mm have been reported in the literature. The submandibular gland and its duct appear to be the most susceptible sites for this disease. In this article, we report two unique cases, including a giant bilateral case, measuring 50 mm in length and 5 mm in width on the right side and one, 30 mm in length, and 5 mm in width on the left side; and another case, measuring 83 mm in length...
September 2015: Dental Research Journal
Nobuyuki Itoh
The FGF family comprises 22 members with diverse functions in development and health. FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor. FGF10and FGFR2b are preferentially expressed in the mesenchyme and epithelium, respectively. FGF10 is a mesenchymal signaling molecule in the epithelium. FGF10 knockout mice die shortly after birth due to the complete absence of lungs as well as fore- and hindlimbs. FGF10 is also essential for the development of multiple organs. The phenotypes of Fgf10 knockout mice are very similar to those of FGFR2b knockout mice, indicating that FGF10 acts as a ligand that is specific to FGFR2b in mouse multi-organ development...
April 2016: Cytokine & Growth Factor Reviews
Niraj Jani, James Buxbaum
Autoimmune pancreatitis (AIP) is part of a systemic fibrosclerotic process characterized by lymphoplasmacytic infiltrate with immunoglobulin G subtype-4 (IgG4) positive cells. It characteristically presents with biliary obstruction due to mass-like swelling of the pancreas. Frequently AIP is accompanied by extra-pancreatic manifestations including retroperitoneal fibrosis, thyroid disease, and salivary gland involvement. Auto-antibodies, hypergammaglobulemia, and prompt resolution of pancreatic and extrapancreatic findings with steroids signify its autoimmune nature...
November 6, 2015: World Journal of Gastrointestinal Pharmacology and Therapeutics
Hiroki Takahashi, Chisako Suzuki, Motohisa Yamamoto
IgG4-related disease (IgG4-RD) is a systemic chronic disease characterized by tumefactive lesions, elevated levels of serum IgG4, and prominent infiltration of IgG4-positive plasma cells with fibrosis. Both lacrimal and salivary glands and the pancreas are the most affected organs during the clinical course of IgG4-RD. The existence of common characteristics associated with IgG4 and frequent overlapping of both diseases has contributed to the establishment of IgG4-RD as a systemic entity. Patients with IgG4-RD are often asymptomatic in the early stage and constitutional symptoms are rarely observed...
May 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
Robert Cordesmeyer, Jan Winterhoff, Philipp Kauffmann, Rainer Laskawi
OBJECTIVES: The diagnosis and therapy of obstructive inflammatory disorders of the salivary glands have changed in the past decades following the introduction of sialoendoscopy. The aims of the present study were to analyze the relevance of sialoendoscopy using our own data and to compare the results to those of other studies. PATIENTS AND METHODS: A retrospective analysis of 70 patients was performed, who were treated for obstructive disorders of the parotid and/or submandibular gland in whom sialoendoscopy was indicated...
June 2016: Clinical Oral Investigations
Eva Rye Rasmussen, Eva Lykke, Niels Wagner, Troels Nielsen, Stian Waersted, Helge Arndal
Excision has been the treatment of choice in benign non-tumorous obstructive disorders of the major salivary glands, when symptoms persisted in spite of conservative measures. Unfortunately surgical resection has been associated with a relatively high rate of adverse effects. To meet the need for a less invasive treatment modality for benign obstructive non-tumorous disorders (i.e., salivary stones or stenosis), sialendoscopy has been developed and implemented in several countries here among Denmark. This study is a 13-year retrospective registry-based study using The Danish National Patient Register...
August 2016: European Archives of Oto-rhino-laryngology
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