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https://www.readbyqxmd.com/read/28229466/insight-into-calculated-risk-an-application-to-the-prioritization-of-emerging-infectious-diseases-for-blood-transfusion-safety
#1
R E J Neslo, W Oei, M P Janssen
Increasing identification of transmissions of emerging infectious diseases (EIDs) by blood transfusion raised the question which of these EIDs poses the highest risk to blood safety. For a number of the EIDs that are perceived to be a threat to blood safety, evidence on actual disease or transmission characteristics is lacking, which might render measures against such EIDs disputable. On the other hand, the fact that we call them "emerging" implies almost by definition that we are uncertain about at least some of their characteristics...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28216184/vaccine-development-for-emerging-virulent-infectious-diseases
#2
Joel N Maslow
The recent outbreak of Zaire Ebola virus in West Africa altered the classical paradigm of vaccine development and that for emerging infectious diseases (EIDs) in general. In this paper, the precepts of vaccine discovery and advancement through pre-clinical and clinical assessment are discussed in the context of the recent Ebola virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Zika virus outbreaks. Clinical trial design for diseases with high mortality rates and/or high morbidity in the face of a global perception of immediate need and the factors that drive design in the face of a changing epidemiology are presented...
February 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28211758/life-cycle-host-utilization-and-ecological-fitting-for-invasive-lancet-liver-fluke-dicrocoelium-dendriticum-emerging-in-southern-alberta-canada
#3
Bradley van Paridon, John S Gilleard, Douglas D Colwell, Cameron P Goater
The expansion of parasite distributions outside of their native host and geographical ranges has occurred repeatedly over evolutionary time. Contemporary examples include emerging infectious diseases (EID's), many of which pose threats to human, domestic animal, and wildlife populations. Theory predicts that parasites with complex life cycles will be rare as EID's due to constraints imposed by host specialization at each life-cycle stage. In contrast to predictions of this theory, we report 2 new intermediate hosts in the 3-host life cycle of the liver fluke Dicrocoelium dendriticum in Cypress Hills Provincial Park, Alberta, Canada...
February 17, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28201806/derivation-and-evaluation-of-putative-adverse-outcome-pathways-for-the-effects-of-cyclooxygenase-inhibitors-on-reproductive-processes-in-female-fish
#4
Dalma Martinović-Weigelt, Alvine C Mehinto, Gerald T Ankley, Jason P Berninger, Timothy W Collette, John M Davis, Nancy D Denslow, Elizabeth J Durhan, Evan Eid, Drew R Ekman, Kathleen M Jensen, Mike D Kahl, Carlie A LaLone, Quincy Teng, Daniel L Villeneuve
No abstract text is available yet for this article.
February 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28196862/mtorc1-activity-is-required-to-maintain-canonical-endocytic-recycling-pathway-against-lysosomal-delivery
#5
Kristin Dauner, Walaa Eid, Riya Raghupathy, John Presley, Xiaohui Zha
The plasma membrane of mammalian cells undergoes constitutive endocytosis, endocytic sorting and recycling, which delivers nutrients to the lysosomes. The receptors, along with membrane lipids, are normally returned to the plasma membrane to sustain this action. It is not known, however, whether this process is influenced by metabolic conditions. Here we report that endocytic recycling requires active mTORC1, a master metabolic sensor. Upon mTORC1 inactivation, either by starvation or by inhibitors, plasma membrane lipids and recycling receptors, such as sphingomyelin and transferrin receptors, are delivered to the lysosomes...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28192979/structural-characterization-of-native-proteins-and-protein-complexes-by-electron-ionization-dissociation-mass-spectrometry
#6
Huilin Li, Yuewei Sheng, William McGee, Michael Cammarata, Dustin Holden, Joseph A Loo
Mass spectrometry (MS) has played an increasingly important role in the identification and structural and functional characterization of proteins. In particular, the use of tandem mass spectrometry has afforded one of the most versatile methods to acquire structural information for proteins and protein complexes. The unique nature of electron capture dissociation (ECD) for cleaving protein backbone bonds while preserving noncovalent interactions has made it especially suitable for the study of native protein structures...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28189073/lower-levels-of-persistent-organic-pollutants-metals-and-the-marine-omega-3-fatty-acid-dha-in-farmed-compared-to-wild-atlantic-salmon-salmo-salar
#7
Anne-Katrine Lundebye, Erik-Jan Lock, Josef D Rasinger, Ole Jakob Nøstbakken, Rita Hannisdal, Egil Karlsbakk, Vidar Wennevik, Abdullah S Madhun, Lise Madsen, Ingvild Eide Graff, Robin Ørnsrud
Contaminants and fatty acid levels in farmed- versus wild Atlantic salmon have been a hot topic of debate in terms of food safety. The present study determined dioxins (polychlorinated dibenzo-p-dioxin and dibenzofuran), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs), metals and fatty acids in wild and farmed Atlantic salmon. Contaminant levels of dioxins, PCBs, OCPs (DDT, dieldrin, lindane, chlordane, Mirex, and toxaphene), and mercury were higher in wild salmon than in farmed salmon, as were the concentrations of the essential elements selenium, copper, zinc and iron, and the marine omega-3 fatty acid docosahexaenoic acid (DHA)...
February 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28187337/brain-morphology-in-school-aged-children-with-prenatal-opioid-exposure-a-structural-mri-study
#8
Eivind Sirnes, Leif Oltedal, Hauke Bartsch, Geir Egil Eide, Irene B Elgen, Stein Magnus Aukland
BACKGROUND: Both animal and human studies have suggested that prenatal opioid exposure may be detrimental to the developing fetal brain. However, results are somewhat conflicting. Structural brain changes in children with prenatal opioid exposure have been reported in a few studies, and such changes may contribute to neuropsychological impairments observed in exposed children. AIM: To investigate the association between prenatal opioid exposure and brain morphology in school-aged children...
February 7, 2017: Early Human Development
https://www.readbyqxmd.com/read/28186983/differentiation-status-of-primary-chronic-myeloid-leukemia-cells-affects-sensitivity-to-bcr-abl1-inhibitors
#9
Paavo O Pietarinen, Christopher A Eide, Pilar Ayuda-Durán, Swapnil Potdar, Heikki Kuusanmäki, Emma I Andersson, John P Mpindi, Tea Pemovska, Mika Kontro, Caroline A Heckman, Olli Kallioniemi, Krister Wennerberg, Henrik Hjorth-Hansen, Brian J Druker, Jorrit M Enserink, Jeffrey W Tyner, Satu Mustjoki, Kimmo Porkka
Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond to TKI therapy. However, there is limited information on the cellular mechanisms of response and particularly on the effect of cell differentiation state to TKI sensitivity in vivo and ex vivo/in vitro. We used multiple, independent high-throughput drug sensitivity and resistance testing platforms that collectively evaluated 295 oncology compounds to characterize ex vivo drug response profiles of primary cells freshly collected from newly-diagnosed patients with BCR-ABL1-positive leukemia (n = 40) and healthy controls (n = 12)...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28181674/population-based-study-on-resection-rates-and-survival-in-patients-with-colorectal-liver-metastasis-in-norway
#10
J-H Angelsen, A Horn, H Sorbye, G E Eide, I M Løes, A Viste
BACKGROUND: Detailed knowledge about the proportion of patients with colorectal liver metastases (CLM) undergoing resection is sparse. The aim of this study was to analyse cumulative resection rates and survival in patients with CLM. METHODS: For this population-based study of patients developing CLM during 2011-2013, data were extracted from the Norwegian Patient Registry and the Cancer Registry of Norway. RESULTS: A total of 2960 patients had CLM; their median overall survival was 10·9 months...
February 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28179591/correction-mtdna-depleted-pc3-cells-exhibit-warburg-effect-and-cancer-stem-cell-features
#11
Xiaoran Li, Yali Zhong, Jie Lu, Karol Axcrona, Lars Eide, Randi G Syljuåsen, Qian Peng, Junbai Wang, Hongquan Zhang, Mariusz Adam Goscinski, Gunnar Kvalheim, Jahn M Nesland, Zhenhe Suo
No abstract text is available yet for this article.
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28166750/erratum-to-does-occupational-therapy-reduce-the-need-for-surgery-in-carpometacarpal-osteoarthritis-protocol-for-a-randomized-controlled-trial
#12
Ingvild Kjeken, Ruth Else Mehl Eide, Åse Klokkeide, Karin Hoegh Matre, Monika Olsen, Petter Mowinckel, Øyvor Andreassen, Siri Darre, Randi Nossum
No abstract text is available yet for this article.
February 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28155925/an-enzyme-induced-au-ag-core-shell-nanostructure-used-for-an-ultrasensitive-surface-enhanced-raman-scattering-immunoassay-of-cancer-biomarkers
#13
Lin Yang, Ming Xuan Gao, Lei Zhan, Min Gong, Shu Jun Zhen, Cheng Zhi Huang
Early detection of cancer is helpful for the control and prevention of diseases. Due to the low content of cancer biomarkers in the early disease phases, however, an ultrasensitive and selective method is critical. In this contribution, an ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay is newly developed with the principle of introducing a common enzyme-induced deposition (EID) reaction to coat a silver layer on the surface of gold nanoparticles and to form a core-shell nanostructure of Au@Ag...
February 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28152278/oligohydramnios-compromises-lung-cells-size-and-interferes-with-epithelial-endothelial-development
#14
Tanbir Najrana, Lauren M Ramos, Rasha Abu Eid, Juan Sanchez-Esteban
BACKGROUND AND OBJECTIVE: Severe oligohydramnios can induce pulmonary hypoplasia. However, the mechanisms by which leaking of fluids cause lung hypoplasia are not well defined. The objective of this study was to characterize a mouse model of pulmonary hypoplasia induced by oligohydramnios. METHODS: Amniotic sacs were punctured on E14.5 of gestation. Untouched fetuses were used as control. Pregnancy was allowed to continue until E18.5 in which lung tissue was collected and evaluated for morphometry, proliferation, differentiation, apoptosis, and angiogenesis...
February 2, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28146249/coronary-angiography-and-percutaneous-coronary-intervention-after-out-of-hospital-cardiac-arrest
#15
Shaker M Eid, Aiham Albaeni, Nisha Chandra-Strobos
No abstract text is available yet for this article.
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28146007/effect-of-isokinetic-training-on-muscle-strength-and-postural-balance-in-children-with-down-s-syndrome
#16
Mohamed A Eid, Sobhy M Aly, Mohamed A Huneif, Dina K Ismail
Children with Down's syndrome (DS) often have greater postural sway and delay in motor development. Muscle weakness and hypotonia, particularly of the lower extremities, are theorized to impair their overall physical health and ability to perform daily activities. Therefore, the aim of this study was to investigate the effects of isokinetic training on muscle strength and postural balance in children with DS. Thirty-one children with DS ranging in age from 9 to 12 years were assigned randomly into two groups...
January 31, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28143568/factors-predicting-training-transfer-in-health-professionals-participating-in-quality-improvement-educational-interventions
#17
Ahmed Eid, Doris Quinn
BACKGROUND: Predictors of quality improvement (QI) training transfer are needed. This study aimed to identify these predictors among health professionals who participated in a QI training program held at a large hospital in the United States between 2005 and 2014. It also aimed to determine how these predictive factors facilitated or impeded QI training transfer. METHODS: Following the Success Case Method, we used a screening survey to identify trainees with high and low levels of training transfer...
January 31, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28143436/erratum-to-typologies-in-gps-referral-practice
#18
Olav Thorsen, Miriam Hartveit, Jan Olav Johannessen, Lars Fosse, Geir Egil Eide, Jörn Schulz, Anders Bærheim
No abstract text is available yet for this article.
January 31, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28138947/energy-sensitive-photon-counting-detector-based-x-ray-computed-tomography
#19
REVIEW
Katsuyuki Taguchi
Energy-sensitive photon counting detectors (PCDs) have recently been developed for medical X-ray computed tomography (CT) imaging and a handful of prototype PCD-CT systems have been built and evaluated. PCDs detect X-rays by using mechanisms that are completely different from the current CT detectors (i.e., energy integrating detectors or EIDs); PCDs count photons and obtain the information of the object tissues (i.e., the effective atomic numbers and mass densities) to be imaged. Therefore, these PCDs have the potential not only for evolution-to improve the current CT images such as providing dose reduction-but also for a revolution-to enable novel applications with a new concept such as molecular CT imaging...
January 30, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28129409/justice-is-the-missing-link-in-one-health-results-of-a-mixed-methods-study-in-an-urban-city-state
#20
Tamra Lysaght, Benjamin Capps, Michele Bailey, David Bickford, Richard Coker, Zohar Lederman, Sangeetha Watson, Paul Anantharajah Tambyah
BACKGROUND: One Health (OH) is an interdisciplinary collaborative approach to human and animal health that aims to break down conventional research and policy 'silos'. OH has been used to develop strategies for zoonotic Emerging Infectious Diseases (EID). However, the ethical case for OH as an alternative to more traditional public health approaches is largely absent from the discourse. To study the ethics of OH, we examined perceptions of the human health and ecological priorities for the management of zoonotic EID in the Southeast Asia country of Singapore...
2017: PloS One
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