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https://www.readbyqxmd.com/read/29785894/developmental-and-molecular-responses-of-buffalo-bubalus-bubalis-cumulus-oocyte-complex-matured-in-vitro-under-heat-shock-conditions
#1
Ashraf El-Sayed, Rehab Nagy, Amal K El-Asheeri, Liala N Eid
SummaryTo investigate the effects of physiologically relevant heat shock during oocyte maturation, buffalo cumulus-oocyte complexes (COCs) were cultured at 38.5°C (control) or were exposed to 39.5°C (T1) or 40.5°C (T2) for the first 6 h of in vitro maturation (IVM), followed by 38.5°C through the next 18 h/IVM and early embryonic development up to the blastocyst stage. Gene expression analysis was performed on selected target genes (HSF-1, HSF-2, HSP-70, HSP-90, BAX, p53, SOD1, COX1, MAPK14) in denuded oocytes and their isolated cumulus cells resulting from control COCs as well as from COCs exposed to a temperature of 39...
May 22, 2018: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29780262/high-mortality-due-to-cutaneous-melanoma-in-norway-a-study-of-prognostic-factors-in-a-nationwide-cancer-registry
#2
Trude Eid Robsahm, Per Helsing, Yngvar Nilssen, Linda Vos, Syed Mohammad H Rizvi, Lars A Akslen, Marit B Veierød
Purpose: The purpose of this study was to examine why Norway has the highest rate of mortality due to cutaneous melanoma (CM) in Europe. The Norwegian Malignant Melanoma Registry (NMMR) enables the study of clinical and histopathological characteristics of patients who die due to CM. Results: The NMMR and the Norwegian Cause of Death Registry provided data on the clinical and histopathological factors as well as the date and cause of death, through June 2015 for all first invasive CMs diagnosed in 2008-2012 (n=8087)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29775992/from-breaking-point-to-breakthrough-during-the-icu-stay-a-qualitative-study-of-family-members-experiences-of-long-term-intensive-care-patients-pathways-towards-survival
#3
Hege S Haugdahl, Regina Eide, Ingeborg Alexandersen, Tove Engan Paulsby, Berit Stjern, Stine Borgen Lund, Gørill Haugan
AIMS AND OBJECTIVES: To explore family members' experiences of long-term intensive care unit (ICU) patients' pathways towards survival and to highlight family members' efforts to promote the patient's health during the ICU stay. BACKGROUND: Although considerable research has been devoted to the substantial burden of long-term ICU patients, less attention has been paid to health promoting factors that facilitate patients' health and survival during ICU stays. Support from family members can improve patient outcome...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29773306/factors-associated-with-timing-and-adverse-outcomes-in-patients-with-biliary-atresia-undergoing-kasai-hepatoportoenterostomy
#4
Michael Ross Townsend, Adeeb Jaber, Hanina Abi Nader, Shaker M Eid, Kathleen Schwarz
OBJECTIVE: To assess factors associated with timing of hepatoportoenterostomy (HPE) and adverse perioperative outcomes in patients with biliary atresia in the US. STUDY DESIGN: We examined hospitalizations in infants aged <1 year using the National Inpatient Sample database for 2000-2011. We identified cases using the International Classification of Diseases, Ninth Revision, Clinical Modification codes for biliary atresia and HPE. Multivariable logistic regression models were used to examine association between select factors and age at HPE, as well as adverse perioperative outcomes...
May 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29770133/peripheral-blood-stem-cell-mobilization-in-healthy-donors-by-granulocyte-colony-stimulating-factor-causes-preferential-mobilization-of-lymphocyte-subsets
#5
Guro Kristin Melve, Elisabeth Ersvaer, Geir Egil Eide, Einar K Kristoffersen, Øystein Bruserud
Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible strategy to reduce this risk without reducing antileukemic immune reactivity. Study design and methods: We investigated the effect of hematopoietic stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) on peripheral blood and stem cell graft levels of various T, B, and NK cell subsets in healthy donors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29770047/emerging-infectious-diseases-prediction-and-detection
#6
N H Ogden, P AbdelMalik, Jrc Pulliam
Emerging infectious diseases (EIDs), including West Nile virus, severe acute respiratory syndrome (SARS) and Lyme disease, have had a direct effect within Canada, while many more EIDs such as Zika, chikungunya and Ebola are a threat to Canadians while travelling. Over 75% of EIDs affecting humans are, or were originally, zoonoses (infectious diseases transmitted from animals to humans). There are two main ways by which infectious diseases can emerge: by changes in their geographical ranges and by adaptive emergence, a genetic change in a microorganism that results in it becoming capable of invading a new niche, often by jumping to a new host species such as humans...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29767558/molecular-basis-of-the-counteraction-by-calcium-channel-blockers-of-cyclosporine-nephrotoxicity
#7
Safaa Hicham Hammoud, Sahar Alkhansa, Neamah Mahjoub, Amal Galal Omar, Mahmoud M El-Mas, Assaad A Eid
Nephrotoxicity is a serious side effect for the immunosuppressant drug cyclosporine (CSA). In this study, we tested the hypothesis that administration of calcium channel blockers such as verapamil or nifedipine ameliorate renal CSA-induced renal dysfunction. Furthermore, our study investigates the roles of inflammatory, oxidative, and fibrotic pathways in CSA-induced renal dysfunction. Six groups of male rats (n=6/group) were used and received one of the following treatments for 7 consecutive days: vehicle (cremophor EL, i...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29766191/palladium-mediated-deallylation-in-fully-aqueous-conditions-for-native-chemical-ligation-at-aspartic-and-glutamic-acid-sites
#8
Muhammad Jbara, Emad Eid, Ashraf Brik
An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.
May 16, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29765491/interplay-of-oxidative-stress-inflammation-and-autophagy-their-role-in-tissue-injury-of-the-heart-liver-and-kidney
#9
EDITORIAL
Partha Mukhopadhyay, Nabil Eid, Mohamed A Abdelmegeed, Aditya Sen
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29759049/klinefelter-s-syndrome-with-lupus-encephalitis-and-retroperitoneal-teratoma
#10
C Ng Wq, S E Eide, Huang J, Khor Ym
We report a case of a middle-aged male who presented with pyrexia of unknown origin, oral ulcers, rash and bicytopenia. His past medical history included unexplained proteinuria, infertility and joint pain. Initial workup showed a large retroperitoneal soft tissue mass, which has appeared stable for 10 years. He subsequently developed neuropsychiatric symptoms with imaging findings of meningoencephalitis. Concurrent investigations showed elevated ANA, anti-double-stranded DNA (dsDNA) and ESR levels, as well as low complement levels...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29755036/pregnancy-related-risk-factors-are-associated-with-a-significant-burden-of-treated-hypertension-within-10-years-of-delivery-findings-from-a-population-based-norwegian-cohort
#11
Grace M Egeland, Svetlana Skurtveit, Anne Cathrine Staff, Geir Egil Eide, Anne-Kjersti Daltveit, Kari Klungsøyr, Lill Trogstad, Per M Magnus, Anne Lise Brantsæter, Margaretha Haugen
BACKGROUND: The association between pregnancy complications and women's later cardiovascular disease has, primarily, been evaluated in studies lacking information on important covariates. This report evaluates the prospective associations between pregnancy-related risk factors (preeclampsia/eclampsia, gestational hypertension, pregestational and gestational diabetes mellitus, preterm delivery, and fetal growth restriction) and pharmacologically treated hypertension within 10 years after pregnancy, while adjusting for a wide range of covariates...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29753540/risk-factors-for-early-dialysis-dependency-in-autosomal-recessive-polycystic-kidney-disease
#12
Kathrin Burgmaier, Kevin Kunzmann, Gema Ariceta, Carsten Bergmann, Anja Katrin Buescher, Mathias Burgmaier, Ismail Dursun, Ali Duzova, Loai Eid, Florian Erger, Markus Feldkoetter, Matthias Galiano, Michaela Geßner, Heike Goebel, Ibrahim Gokce, Dieter Haffner, Nakysa Hooman, Bernd Hoppe, Augustina Jankauskiene, Guenter Klaus, Jens König, Mieczyslaw Litwin, Laura Massella, Djalila Mekahli, Engin Melek, Sevgi Mir, Lars Pape, Larisa Prikhodina, Bruno Ranchin, Raphael Schild, Tomas Seeman, Lale Sever, Rukshana Shroff, Neveen A Soliman, Stella Stabouli, Malgorzata Stanczyk, Yilmaz Tabel, Katarzyna Taranta-Janusz, Sara Testa, Julia Thumfart, Rezan Topaloglu, Lutz Thorsten Weber, Dorota Wicher, Elke Wühl, Simone Wygoda, Alev Yilmaz, Katarzyna Zachwieja, Ilona Zagozdzon, Klaus Zerres, Jörg Dötsch, Franz Schaefer, Max Christoph Liebau
OBJECTIVE: To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. STUDY DESIGN: A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. RESULTS: Thirty-six out of 385 children (9...
May 9, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29751643/the-effect-of-lean-seafood-and-non-seafood-diets-on-fasting-and-postprandial-serum-metabolites-and-lipid-species-results-from-a-randomized-crossover-intervention-study-in-healthy-adults
#13
Mette Schmedes, Claudia Balderas, Eli Kristin Aadland, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Ulrik Kræmer Sundekilde, Bjørn Liaset, Hanne Christine Bertram
The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults ( n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29750654/initial-presentations-and-associated-clinical-findings-in-patients-with-classical-congenital-adrenal-hyperplasia
#14
Asmaa Adel Milyani, Abdulmoein Eid Al-Agha, Mashael Al-Zanbagi
BACKGROUND: The objective of this study was to investigate the initial presenting features of children with classical congenital adrenal hyperplasia (CAH). METHODS: This is a descriptive retrospective study over a period of 5 years. Data analysis was performed using Statistical Package for Social Science. RESULTS: Ambiguous genitalia (AG) was the commonest initial presentation marking 50.7% of the patients. On the other hand, 33.3% presented with a salt-losing crisis, 4...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29746776/from-cancer-to-pain-target-by-automated-selectivity-inversion-of-a-clinical-candidate
#15
Samo Turk, Benjamin Merget, Sameh Eid, Simone Fulle
Elimination of inadvertent binding is crucial for inhibitor design targeting conserved protein classes like kinases. Compounds in clinical trials provide a rich source for initiating drug design efforts by exploiting such secondary binding events. Considering both aspects, we shifted the selectivity of tozasertib, originally developed against AurA as cancer target, towards the pain target TrkA. First, selectivity-determining features in binding pockets were identified by fusing interaction-grids of several key and off-target conformations...
May 10, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29744690/predicting-the-origins-of-next-forest-based-emerging-infectious-disease
#16
Vishal Shah, Anand Shah, Varoon Joshi
Land use change near dense forests is the single major cause of emergence of forest-based emerging infectious diseases (EIDs) among humans. In an attempt to predict where the next EID would originate from, we are hypothesizing that future EIDs would originate from a region having high population density, excessive poverty, and is located near dense vegetation. Using ArcGIS, we identified forest regions in ten countries across the globe that meet all the three conditions identified in the hypothesis. We further narrowed down the locations using Global Forest Watch data, which eliminates locations next to protected forests and fragmented forests...
May 9, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29744234/levels-of-essential-elements-in-different-medicinal-plants-determined-by-using-inductively-coupled-plasma-mass-spectrometry
#17
Eid I Brima
The objective of this study was to investigate the content of essential elements in medicinal plants in the Kingdom of Saudi Arabia (KSA). Five different medical plants (mahareeb (Cymbopogon schoenanthus) , sheeh (Artemisia vulgaris) , harjal (Cynanchum argel delile) , nabipoot (Equisetum arvense) , and cafmariam (Vitex agnus-castus) ) were collected from Madina city in the KSA. Five elements Fe, Mn, Zn, Cu, and Se were determined by using inductively coupled plasma mass spectrometry (ICP-MS). Fe levels were the highest and Se levels were the lowest in all plants...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29741960/ecological-interface-design-for-computer-network-defense
#18
Kevin B Bennett, Adam Bryant, Christen Sushereba
OBJECTIVE: A prototype ecological interface for computer network defense (CND) was developed. BACKGROUND: Concerns about CND run high. Although there is a vast literature on CND, there is some indication that this research is not being translated into operational contexts. Part of the reason may be that CND has historically been treated as a strictly technical problem, rather than as a socio-technical problem. METHODS: The cognitive systems engineering (CSE)/ecological interface design (EID) framework was used in the analysis and design of the prototype interface...
May 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29740121/magnetic-resonance-imaging-provides-evidence-of-glymphatic-drainage-from-human-brain-to-cervical-lymph-nodes
#19
Per Kristian Eide, Svein Are Sirirud Vatnehol, Kyrre Eeg Emblem, Geir Ringstad
Pre-clinical research in rodents provides evidence that the central nervous system (CNS) has functional lymphatic vessels. In-vivo observations in humans, however, are not demonstrated. We here show data on CNS lymphatic drainage to cervical lymph nodes in-vivo by magnetic resonance imaging (MRI) enhanced with an intrathecal contrast agent as a cerebrospinal fluid (CSF) tracer. Standardized MRI of the intracranial compartment and the neck were acquired before and up to 24-48 hours following intrathecal contrast agent administration in 19 individuals...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734121/factors-associated-with-obstetric-anal-sphincter-injuries-in-midwife-led-birth-a-cross-sectional-study
#20
Jorunn Wik Tunestveit, Elham Baghestan, Gerd Karin Natvig, Geir Egil Eide, Anne Britt Vika Nilsen
INTRODUCTION: Obstetric anal sphincter injurie (OASI) in vaginal births are a serious complication, and are associated with maternal morbidity. Focus on modifiable factors in midwives clinical skills and competences contributing to prevent the occurrence of OASI are essential. The objective of this study was to investigate the association between OASI and factors related to midwife-led birth such as manual support of perineum, active delivery of baby's shoulders, maternal birth position, and pushing and breathing techniques in second stage of labour...
April 21, 2018: Midwifery
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