keyword
MENU ▼
Read by QxMD icon Read
search

pH homeostasis

keyword
https://www.readbyqxmd.com/read/28546124/stressor-driven-extracellular-acidosis-as-tumor-inducer-via-aberrant-enzyme-activation-a-review-on-the-mechanisms-and-possible-prophylaxis
#1
REVIEW
Seema Patel
When the extracellular pH of the human body vacillates in either direction, tissue homeostasis is compromised. Fluctuations in acidosis have been linked to a wide variety of pathological conditions, including bone loss, cancer, allergies, and auto-immune diseases. Stress conditions may affect oxygen tension and hypoxia modulates the expression and/or activity of membrane tethered transporters/pumps, transcription factors, enzymes and intercellular junctions. These modifications provoke erratic gene expression, aberrant tissue remodeling and oncogenesis...
May 22, 2017: Gene
https://www.readbyqxmd.com/read/28536975/a-new-hope-for-a-devastating-disease-hydrogen-sulfide-in-parkinson-s-disease
#2
REVIEW
Xu Cao, Lei Cao, Lei Ding, Jin-Song Bian
Hydrogen sulfide (H2S) has been regarded as the third gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). In mammalian brain, H2S is produced redundantly by four enzymatic pathways, implying its abundance in the organ. In physiological conditions, H2S has been found to induce the formation of long-term potential in neuronal cells by augmenting the activity of N-methyl-D-aspartate (NMDA) receptor. Likewise, it also actively takes part in the regulation of intracellular Ca(2+) and pH homeostasis in both neuronal cells and glia cells...
May 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28536480/generation-and-characterization-of-acid-tolerant-fibrobacter-succinogenes-s85
#3
Chia-Wei Wu, Thomas Spike, Dawn M Klingeman, Miguel Rodriguez, Virgil R Bremer, Steven D Brown
Microorganisms are key components for plant biomass breakdown within rumen environments. Fibrobacter succinogenes have been identified as being active and dominant cellulolytic members of the rumen. In this study, F. succinogenes type strain S85 was adapted for steady state growth in continuous culture at pH 5.75 and confirmed to grow in the range of pH 5.60-5.65, which is lower than has been reported previously. Wild type and acid tolerant strains digested corn stover with equal efficiency in batch culture at low pH...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536287/kisameet-glacial-clay-an-unexpected-source-of-bacterial-diversity
#4
Sarah L Svensson, Shekooh Behroozian, Wanjing Xu, Michael G Surette, Loretta Li, Julian Davies
Widespread antibiotic resistance among bacterial pathogens is providing the impetus to explore novel sources of antimicrobial agents. Recently, the potent antibacterial activity of certain clay minerals has stimulated scientific interest in these materials. One such example is Kisameet glacial clay (KC), an antibacterial clay from a deposit on the central coast of British Columbia, Canada. However, our understanding of the active principles of these complex natural substances is incomplete. Like soils, clays may possess complex mixtures of bacterial taxa, including the Actinobacteria, a clade known to be rich in antibiotic-producing organisms...
May 23, 2017: MBio
https://www.readbyqxmd.com/read/28530543/using-properties-of-tumor-microenvironments-for-controlling-local-on-demand-delivery-from-biopolymer-based-nanocarriers
#5
Abdullah K Alshememry, Suleiman S El-Tokhy, Larry D Unsworth
BACKGROUND: The 'tumor microenvironment' comprised of tumor cells, non-malignant stromal tissues, signaling molecules and the extracellular matrix. Tumor microenvironment has unique physical and physiological characteristics including vascular abnormalities, hypoxia, acidic pH, specific enzymes and growth factors upregulation and high reducing potential. It is these endogenous properties of the tumor environment that can be used to trigger the release of cancer therapeutics both locally and as a function of disease state...
May 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28514187/diphenhydramine-inhibits-voltage-gated-proton-channels-hv1-and-induces-acidification-in-leukemic-jurkat-t-cells-new-insights-into-the-pro-apoptotic-effects-of-antihistaminic-drugs
#6
Agustín Asuaje, Pedro Martín, Nicolás Enrique, Leandro Agustín Díaz Zegarra, Paola Smaldini, Guillermo Docena, Verónica Milesi
An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellular acidification and apoptosis induction...
May 17, 2017: Channels
https://www.readbyqxmd.com/read/28510784/effects-of-acute-and-chronic-hypoxia-on-acid-base-regulation-hematology-ion-and-osmoregulation-of-juvenile-american-paddlefish
#7
Daniel L Aboagye, Peter J Allen
Despite the increasing prevalence of hypoxia in natural habitats occupied by the American paddlefish, basal bony fish, and ram ventilator, information about its response to hypoxia is scarce. To understand the physiological and biochemical responses of juvenile paddlefish (~150 g) to acute (<24 h) and chronic hypoxia (≥24 h), blood oxygen transport, blood acid-base balance, and metabolic stress were evaluated under four different partial pressures of oxygen [pO2; normoxia (148 mmHg), mild hypoxia (89 mmHg), moderate hypoxia (59 mmHg), and extreme hypoxia (36 mmHg)], all at 21 °C...
May 16, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28507572/transient-dilutional-acidosis-but-no-lactic-acidosis-upon-cardiopulmonary-bypass-in-patients-undergoing-coronary-artery-bypass-grafting
#8
Johanna Katharina Teloh, Daniel-Sebastian Dohle, Serhat Sönmez, Konstantinos Tsagakis, Rabea Verhaegh, Miriam Petersen, Heinz Jakob, Herbert de Groot
INTRODUCTION: Dilutional acidosis may result from the introduction of a large fluid volume into the patients' systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial pressure. Its significance or even existence, however, has been strongly questioned. Blood gas samples of patients operated on with standard cardiopulmonary bypass (CPB) were analyzed in order to provide further evidence for the existence of dilutional acidosis...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28502056/overexpression-of-the-nitrate-transporter-osnrt2-3b-improves-rice-phosphorus-uptake-and-translocation
#9
Huimin Feng, Bin Li, Yang Zhi, Jingguang Chen, Ran Li, Xiudong Xia, Guohua Xu, Xiaorong Fan
Overexpression of OsNRT2.3b in rice can increase Pi uptake and accumulation through advanced root system, enhanced OsPT and OsPHR genes expression, and the phloem pH homeostasis. Nitrogen (N) and phosphorus (P) are two essential macronutrients for plants. Overexpression of the rice nitrate transporter, OsNRT2.3b, can improve rice grain yield and nitrogen use efficiency (NUE). Here, OsNRT2.3b overexpression resulted in increased grain yield, straw yield, and grain:straw ratio, accompanied by increased P concentrations in the leaf blade, leaf sheath, culm, and unfilled rice hulls...
May 13, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28500239/vacuolar-and-plasma-membrane-proton-pumps-collaborate-to-achieve-cytosolic-ph-homeostasis-in-yeast
#10
Gloria A Martínez-Muñoz, Patricia Kane
No abstract text is available yet for this article.
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28495450/rho-guanine-nucleotide-exchange-factor-rgnef-is-a-prosurvival-factor-under-stress-conditions
#11
Kevin Cheung, Cristian A Droppelmann, Adam MacLellan, Ian Cameron, Benjamin Withers, Danae Campos-Melo, Kathryn Volkening, Michael J Strong
Rho guanine nucleotide exchange factor (RGNEF) is a 190kDa RNA binding protein (RBP) that also contains a Dbl/PH domain capable of RhoA activation. Consistent with a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS), RGNEF forms pathological neuronal cytoplasmic inclusions in degenerating spinal motor neurons. To further understand the role of RGNEF in the stress response, we first observed that the expression of RGNEF is upregulated in murine spinal motor neurons following distal sciatic nerve injury...
May 8, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28492555/acidic-ph-is-essential-for-maintaining-mast-cell-secretory-granule-homeostasis
#12
Gunnar Pejler, Jun Mei Hu Frisk, Daniel Sjöström, Aida Paivandy, Helena Öhrvik
It has been recognized for a long time that the secretory granules of mast cells are acidic, but the functional importance of maintaining an acidic pH in the mast cell granules is not fully understood. Here we addressed this issue by examining the effects of raising the pH of the mast cell secretory granules. Mast cells were incubated with bafilomycin A1, an inhibitor of the vacuolar-type ATPase proton pump. Supporting a role of vacuolar-type ATPase in mast cell granule acidification, bafilomycin A1 treatment caused a robust increase in granule pH...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28490422/cftr-mediated-anion-secretion-across-intestinal-epithelium-like-caco-2-monolayer-under-pth-stimulation-is-dependent-on-intermediate-conductance-k-channels
#13
Walailak Jantarajit, Kornkamon Lertsuwan, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, Narattaphol Charoenphandhu
Parathyroid hormone (PTH), a pleiotropic hormone that maintains mineral homeostasis, is also essential for controlling pH balance and ion transport across renal and intestinal epithelia. Optimization of luminal pH is important for absorption of trace elements, e.g., calcium and phosphorus. We have previously demonstrated that PTH rapidly stimulated electrogenic HCO3(-) secretion in intestinal epithelial-like Caco-2 monolayer, but the underlying cellular mechanism, contributions of other ions, particularly Cl(-) and K(+), and long-lasting responses are not completely understood...
May 10, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28488569/gene-expression-in-the-liver-remnant-is-significantly-affected-by-the-size-of-partial-hepatectomy-an-experimental-rat-study
#14
Michelle Meier, Anders Riegels Knudsen, Kasper Jarlhelt Andersen, Niels Christian Bjerregaard, Uffe Birk Jensen, Frank Viborg Mortensen
<p>Background Extended hepatectomies may result in post-hepatectomy liver failure, a conditionwith a high mortality. The main purpose of the present study was to investigate and compare the gene expression profiles in rats subjected to increasing size of partial hepatectomy.</p><p>Methods 30 Wistar rats were subjected to 30%, 70%, or 90% partial hepatectomy, sham operation or no operation. 24 hours following resection liver tissue was harvested and genome wide expression analysis was performed...
May 9, 2017: Gene Expression
https://www.readbyqxmd.com/read/28486080/arginine-improves-ph-homeostasis-via-metabolism-and-microbiome-modulation
#15
M Agnello, L Cen, N C Tran, W Shi, J S McLean, X He
Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in maintaining plaque pH homeostasis. There is evidence that the use of arginine in dentifrices helps protect against caries. The aim of the current study was to investigate the mechanistic and ecological effect of arginine treatment on the oral microbiome and its regulation of pH dynamics, using an in vitro multispecies oral biofilm model that was previously shown to be highly reflective of the in vivo oral microbiome...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28476673/soluble-adenylyl-cyclase-mediates-mitochondrial-pathway-of-apoptosis-and-atp-metabolism-in-oyster-crassostrea-gigas-exposed-to-elevated-co2
#16
Xiudan Wang, Mengqiang Wang, Jiachao Xu, Zhihao Jia, Zhaoqun Liu, Lingling Wang, Linsheng Song
Ocean acidification (OA) has deleterious impacts on immune response and energy homeostasis status of Mollusca. In the present study, the apoptosis ratio of hemocytes and the adenosine triphosphate (ATP) allocation in gill tissues were determined after Pacific oysters Crassostrea gigas were exposed to elevated CO2 environment (pH = 7.50) for 16 days.The apoptosis ratio in CO2 exposure group (35.2%) was significantly higher (p < 0.05) than that in the control group, and the increased apoptosis ratio induced by elevated CO2 could be significantly inhibited (p < 0...
May 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28474871/effects-of-hydrogen-rich-water-on-prolonged-intermittent-exercise
#17
Alessandro DA Ponte, Nicola Giovanelli, Daniele Nigris, Stefano Lazzer
BACKGROUND: Recent studies showed a positive effect of Hydrogen Rich Water (HRW) intake on acid-basic homeostasis at rest. We investigated 2-weeks of HRW intake on repeated sprint performance and acid-base status during prolonged intermittent cycling exercise. METHODS: In a cross over single-blind protocol, eight trained male cyclists (age [mean ± SD] 41±7 years, body mass 72.3±4.4 kg, height 1.77±0.04 m, maximal oxygen uptake [V̇ O2max] 52.6±4.4 ml·kg-1·min-1) were provided daily with 2 liters of placebo normal water (PLA, pH 7...
April 26, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28466911/stepwise-copper-i-binding-to-metallothionein-a-mixed-cooperative-and-non-cooperative-mechanism-for-all-20-copper-ions
#18
Judith S Scheller, Gordon W Irvine, Daisy L Wong, Andrea Hartwig, Martin J Stillman
Copper is a ubiquitous trace metal of vital importance in that it serves as a cofactor in many metalloenzymes. Excess copper becomes harmful if not sequestered appropriately in the cell. As a metal ion chaperone, metallothionein (MT) has been proposed as a key player in zinc and copper homeostasis within the cell. The underlying mechanisms by which MT sequesters and transfers copper ions, and subsequently achieves its proposed biological function remain unknown. Using a combination of electrospray ionization mass spectrometry (ESI-MS), circular dichroism (CD), and emission spectroscopy, we report that the Cu(i) to human apo-MT1a binding mechanism is highly pH-dependent...
May 24, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28466262/observation-of-parkin-mediated-mitophagy-in-pancreatic-%C3%AE-cells
#19
Atsushi Hoshino, Satoaki Matoba
Mitophagy is a cellular process of autophagy-based mitochondrial degradation that eliminates dysfunctional mitochondria and ensures cellular homeostasis. In pancreatic islet β-cells, mitochondria play a pivotal role in glucose-stimulated insulin secretion through ATP production from glucose oxidation. Recent studies have shown that impaired mitophagy and the subsequent mitochondrial compromise contribute to β-cell dysfunction and glucose intolerance. In this chapter, we describe a protocol to monitor Parkin-mediated mitophagy in pancreatic MIN6 β-cells using flow cytometry and a pH-sensitive fluorophore, mKeima...
May 3, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28445245/ectopic-expression-of-innate-immune-protein-lipocalin-2-in-lactococcus-lactis-protects-against-gut-and-environmental-stressors
#20
Piu Saha, Benoit Chassaing, Beng San Yeoh, Emilie Viennois, Xia Xiao, Mary J Kennett, Vishal Singh, Matam Vijay-Kumar
BACKGROUND: Lipocalin-2 (Lcn2) is a multifunctional innate immune protein that exhibits antimicrobial activity by the sequestration of bacterial siderophores, regulates iron homeostasis, and augments cellular tolerance to oxidative stress. Studies in the murine model of colitis have demonstrated that Lcn2 deficiency exacerbates colitogenesis; however, the therapeutic potential of Lcn2 supplementation has yet to be elucidated. In light of its potential mucoprotective functions, we, herein, investigated whether expression of Lcn2 in the probiotic bacterium can be exploited to alleviate experimental colitis...
April 25, 2017: Inflammatory Bowel Diseases
keyword
keyword
76484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"