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Cardiac function in lvh

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https://www.readbyqxmd.com/read/27884234/the-hypertensive-myocardium-from-microscopic-lesions-to-clinical-complications-and-outcomes
#1
REVIEW
María U Moreno, Rocío Eiros, Juan J Gavira, Catalina Gallego, Arantxa González, Susana Ravassa, Begoña López, Javier Beaumont, Gorka San José, Javier Díez
The chronic hemodynamic load imposed by hypertension on the left ventricle leads to lesions in the myocardium that result in structural remodeling, which provides support for alterations in cardiac function, perfusion, and electrical activity that adversely influence the clinical evolution of hypertensive heart disease. Management must include detecting, reducing, and reversing left ventricular hypertrophy, as well as the detection and repair of microscopic lesions responsible for myocardial remodeling. Reducing the burden associated with hypertensive heart disease can be targeted using personalized treatment...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27882404/reduced-trans-mitral-a-wave-velocity-predicts-the-presence-of-wild-type-transthyretin-amyloidosis-in-elderly-patients-with-left-ventricular-hypertrophy
#2
Satoru Yamamura, Yasuhiro Izumiya, Toshifumi Ishida, Yoshiro Onoue, Yuichi Kimura, Shinsuke Hanatani, Satoshi Araki, Koichiro Fujisue, Daisuke Sueta, Hisanori Kanazawa, Seiji Takashio, Hiroki Usuku, Koichi Sugamura, Kenji Sakamoto, Eiichiro Yamamoto, Megumi Yamamuro, Hisayo Yasuda, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa, Kenichi Tsujita
Wild-type transthyretin amyloidosis (ATTRwt) is often overlooked in elderly patients with left ventricular hypertrophy (LVH). Impaired atrial function, in addition to ventricular diastolic dysfunction, is one of the hallmarks of cardiac amyloidosis. Here, we assessed the hypothesis that atrial function evaluated by A-velocity in pulse Doppler echocardiography is useful to differentiate ATTRwt in elderly patients with LVH. We analyzed 133 consecutive patients who underwent tissue biopsy to rule out infiltrative cardiomyopathy in our institute...
November 23, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27881564/heart-failure-stages-among-older-adults-in-the-community-the-atherosclerosis-risk-in-communities-study
#3
Amil M Shah, Brian Claggett, Laura R Loehr, Patricia P Chang, Kunihiro Matsushita, Dalane Kitzman, Suma H Konety, Anna Kucharska-Newton, Carla A Sueta, Thomas H Mosley, Jacqueline D Wright, Josef Coresh, Gerardo Heiss, Aaron R Folsom, Scott D Solomon
BACKGROUND: -Although HF disproportionately affects older adults, little data exist regarding the prevalence of American College of Cardiology/American Heart Association heart failure (HF) stages among older individuals in the community. Additionally, the role of contemporary measures of longitudinal strain (LS) and diastolic dysfunction in defining HF stages is unclear. METHODS: -HF stages were classified in 6,118 participants in the Atherosclerosis Risk in Communities study (age 67 - 91 years) at the fifth study visit as follows: stage A (asymptomatic with HF risk factors but no cardiac structural or functional abnormalities), B (asymptomatic with structural abnormalities, defined as left ventricular hypertrophy, dilation or dysfunction, or significant valvular disease), C1 (clinical HF without prior hospitalization), and C2 (clinical HF with prior hospitalization)...
November 23, 2016: Circulation
https://www.readbyqxmd.com/read/27866432/maternal-cardiac-haemodynamics-in-severe-pre-eclampsia-complicated-by-acute-pulmonary-oedema-a-review
#4
I Bhorat, D P Naidoo, J Moodley
AIM: To establish alterations in maternal cardiac haemodynamics and function using electrocardiography and echocardiography in severe pre-eclampsia complicated by acute pulmonary oedema. METHODS: An extensive literature search including any research articles, randomised control trials, observational study, case report or expert or consensus statement pertaining to severe pre-eclampsia, eclampsia, hypertensive crises of pregnancy, pulmonary oedema, maternal cardiac haemodynamics, Holter monitoring and maternal echocardiography was done...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27822774/-cardiovascular-manifestations-in-systemic-lupus-erythematosus-in-dakar-descriptive-study-about-50-cases
#5
A A Ngaïdé, F Ly, K Ly, M Diao, Ad Kane, A Mbaye, M Lèye, F Aw, S A Sarr, M Dioum, C T Ndao, N D Gaye, M B Ndiaye, M Bodian, M B Bah, M Ndiaye, A F Cissé, I Kouamé, A Tabane, J S Mingou, P Thiombiano, A Kane, S A Bâ
Systemic lupus erythematosus is a non-specific inflammatory disorder of an organ of unknown cause and autoimmune origin. Visceral injuries, including those cardiovascular, determine the prognosis of this disease primarily affecting women. The objectives of this study were to determine the frequency and describe the cardiovascular manifestations in systemic lupus erythematosus in a lupus population of the Dakar region. This is a multicenter prospective study descriptive and analytical conducted in the region of Dakar (Senegal) from 14 February 2011 to 2 July 2012...
November 7, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27807682/dilated-cardiomyopathy-as-the-only-clinical-manifestation-of-carnitine-transporter-deficiency
#6
Kyriaki Papadopoulou-Legbelou, Maria Gogou, Vaia Dokousli, Maria Eboriadou, Athanasios Evangeliou
The authors present a case of carnitine transporter deficiency, which was unmasked after an episode of respiratory distress resistant to treatment with bronchodilators. Chest radiograph showed cardiomegaly; electrocardiogram showed left ventricular hypertrophy and echocardiography revealed dilated cardiomyopathy. Heart failure therapy was initiated and metabolic screening was requested, as family history was indicative of inborn errors of metabolism. Very low levels of free carnitine and carnitine esters in blood were found and genetic testing confirmed the diagnosis of carnitine transporter deficiency...
November 3, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27789290/ablation-of-biglycan-attenuates-cardiac-hypertrophy-and-fibrosis-after-left-ventricular-pressure-overload
#7
Nadine Beetz, Carolin Rommel, Tilman Schnick, Elena Neumann, Achim Lother, Elsa Beatriz Monroy-Ordonez, Martin Zeeb, Sebastian Preissl, Ralf Gilsbach, Ariane Melchior-Becker, Bartosz Rylski, Monika Stoll, Liliana Schaefer, Friedhelm Beyersdorf, Brigitte Stiller, Lutz Hein
AIMS: Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of biglycan in the development and regression of cardiomyocyte hypertrophy and fibrosis during cardiac pressure overload and unloading remains elusive. Thus, the aim of the present study was to assess the effect of biglycan on cardiac remodeling in a mouse model of left ventricular pressure overload and unloading...
October 24, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27754254/os-36-05-tetrahydrobiopterin-reverse-left-ventricular-hypertrophy-and-diastolic-dysfunction-through-the-pi3k-p-akt-pathway-in-spontaneously-hypertensive-rats
#8
Qiongying Wang, Peng Chang, Han Xu, Feng Bai, Jing Yu
OBJECTIVE: Hypertension induced hypertrophy and diastolic dysfunction and is associated with cardiac oxidation and reduced NO production. We hypothesized that tetrahydrobiopterin (BH4) can regulate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and reverse cardiac hypertrophy and diastolic dysfunction in spontaneously hypertensive rats. DESIGN AND METHOD: Ten-week-old male spontaneously hypertensive rats (SHR) and age-matched normotensive control Wistar-Kyoto (WKY) rats were divided into five groups, WKY,WKY + BH4, SHR, SHR + BH4 and SHR + VAL...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754253/os-36-04-kruppel-like-factor-15-is-associated-with-cardiac-hypertrophy-in-an-experimental-model-of-kidney-disease
#9
Sheila Patel, Elena Velkoska, Louise Burrell
OBJECTIVE: Left ventricular hypertrophy (LVH) is prevalent in chronic kidney disease (CKD) and a major cause of cardiovascular morbidity and mortality. Treatment of LVH in CKD is based on blood pressure control. The Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy and fibrosis. The role of cardiac KLF15 in the development of LVH in rats with CKD secondary to subtotal nephrectomy (STNx) or the effects of ACE inhibition on KLF15 levels has not been addressed previously...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754142/os-27-06-independent-prognostic-value-of-left-ventricular-mass-diastolic-function-and-fasting-plasma-glucose-a-population-based-cohort-study
#10
Manan Pareek, Mette Lundgren Nielsen, Margrét Leósdóttir, Peter M Nilsson, Michael Hecht Olsen
OBJECTIVE: To explore the independent prognostic value of left ventricular (LV) mass, diastolic function, and fasting plasma glucose (FPG) for the prediction of incident cardiac events in a random population sample. DESIGN AND METHOD: 415 women and 999 men aged 56-79 years, included between 2002-2006, underwent echocardiography based on groups defined by FPG, i.e. normal (NFG): FPG ≤ 6.0 mmol/L; impaired (IFG): FPG 6.1-6.9 mmol/L; and diabetes mellitus (DM): FPG ≥ 7...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754139/os-27-03-impaired-diastolic-recovery-before-discharge-is-associated-with-re-hospitalization-with-hypertensive-heart-failure
#11
Hyun Ju Yoon
OBJECTIVE: The aim of this study was to investigate the impact of diastolic functional recovery on pre-discharge echocardiography on future adverse events in the patients with hypertensive heart failure (HHF). DESIGN AND METHOD: A total of 136 hospitalized patients with HHF were divided into 2 groups according to the change of diastolic function on pre-discharge echocardiography; the improving group (n = 65, 47.9 ± 14.4years, 49 males) vs non-improving group (n = 71, 52...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754118/os-23-05-left-ventricular-hypertrophy-and-significant-coronary-arterial-stenosis-interaction-in-hypertensive-women
#12
Mi-Seung Shin, Seong-Mi Park, Mi-Na Kim, Hack-Lyoung Kim, Kyung-Soon Hong, Myung-A Kim, Gil-Ja Shin, Wan-Joo Shim
OBJECTIVE: Left ventricular hypertrophy (LVH) and coronary atherosclerosis are common cardiac complications of hypertension. Previous studies have shown that LVH is associated with increased cardiovascular mortality, regardless of coronary artery disease. The purpose of this study was to evaluate the relationship between LVH and significant coronary arterial stenosis in hypertensive women with chest pain. DESIGN AND METHOD: One hundred ninety four hypertensive women with eligible data from the Korean women's chest pain registry (KoROSE) study were included...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#13
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753855/hw-01-3-cardiac-and-vascular-mri-in-hypertension-evaluation
#14
Sang-Chol Lee
Chronic hypertension can result in deleterious effects on various vascular organs including the heart and vessels. Cardiovascular magnetic resonance (CMR) has the unique advantage of the ability to assess ventricular volumes and function, valvular abnormalities, vascular pathology, myocardial perfusion and tissue characterization with high accuracy and reproducibility and also avoid the risk of radiation. As this is the case, CMR seems to be an ideal method for comprehensive assessment of patients with systemic hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751193/the-role-of-echocardiography-in-the-evaluation-of-cardiac-re-modelling-and-differentiation-between-physiological-and-pathological-hypertrophy-in-teenagers-engaged-in-competitive-amateur-sports
#15
Ljiljana S Sulovic, Meho Mahmutovic, Snezana Lazic, Nenad Sulovic
: Aims "Athlete's heart" is a cardiac adaptation to long-term intensive training. The aims of this study were to show the prevalence of left ventricular hypertrophy in teenagers who participate in sports, to define the different types of cardiac re-modelling, and to differentiate between physiological and pathological hypertrophy. METHOD: Echocardiographic measurements were obtained by M-mode, two dimensional, and Doppler techniques of participants from sports and control groups...
October 18, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27741021/left-atrial-performance-in-the-course-of-hypertrophic-cardiomyopathy-relation-to-left-ventricular-hypertrophy-and-fibrosis
#16
Johannes T Kowallick, Miguel Silva Vieira, Shelby Kutty, Joachim Lotz, Gerd Hasenfu, Amedeo Chiribiri, Andreas Schuster
OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is associated with left atrial (LA) functional abnormalities. The determinants and the degree of LA dysfunction in the course of HCM are not fully understood. We aimed to characterize LA mechanics in HCM, according to the extent of left ventricular (LV) hypertrophy and fibrosis. METHODS AND RESULTS: Seventy-three HCM patients and 23 age- and sex-matched controls underwent cardiovascular magnetic resonance imaging including late gadolinium enhancement (LGE)...
October 12, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27733425/cardiovascular-dysfunction-and-frailty-among-older-adults-in-the-community-the-aric-study
#17
Wilson Nadruz, Dalane Kitzman, Beverly Gwen Windham, Anna Kucharska-Newton, Kenneth Butler, Priya Palta, Michael E Griswold, Lynne E Wagenknecht, Gerardo Heiss, Scott D Solomon, Hicham Skali, Amil M Shah
BACKGROUND: The contribution of cardiovascular dysfunction to frailty in older adults is uncertain. This study aimed to define the relationship between frailty and cardiovascular structure and function, and determine whether these associations are independent of coexisting abnormalities in other organ systems. METHODS: We studied 3,991 older adults (mean age 75.6±5.0 years; 59% female) from the Atherosclerosis Risk in Communities (ARIC) Study in whom the following six organ systems were uniformly assessed: cardiac (by echocardiography), vascular (by ankle-brachial-index and pulse-wave-velocity), pulmonary (by spirometry), renal (by estimated glomerular filtration rate), hematologic (by hemoglobin), and adipose (by body mass index and bioimpedance)...
October 12, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27730776/cardiac-diastolic-dysfunction-and-regional-body-fat-distribution-in-insulin-resistant-peripubertal-obese-males
#18
A V Sahasrabuddhe, S U Pitale, Dhoble, J Shivalkar, M M Sagdeo
BACKGROUND: To evaluate presence of diastolic dysfunction in obese peripubertal males (8-18 years of age). To correlate diastolic dysfunction with insulin resistance, insulin levels and omental and epicardial fat. METHODS: Obese males (n=46) and age matched healthy lean controls (n=50) in the age group of 8-18 years were included in this study. Anthropometric measurements were recorded. Investigations done: Fasting blood sugar and serum insulin levels, lipid profile, 2-D Echocardiography to assess left ventricular diastolic function and epicardial fat, abdominal CT scan to measure omental fat and ultrasound for NAFLD...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27711172/nt-probnp-predicts-cardiovascular-death-in-the-general-population-independent-of-left-ventricular-mass-and-function-insights-from-a-large-population-based-study-with-long-term-follow-up
#19
Alexander Dietl, Klaus Stark, Martina E Zimmermann, Christa Meisinger, Heribert Schunkert, Christoph Birner, Lars S Maier, Annette Peters, Iris M Heid, Andreas Luchner
AIMS: B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) predict cardiovascular endpoints in patients and all-cause death in the general population. This was assigned to their association with clinical cardiac remodelling defined as changes in size, shape and function of the heart. The aim of this study was to evaluate whether NT-proBNP and BNP were associated with cardiovascular and overall death independent of clinical cardiac remodelling measured by echocardiography as left ventricular hypertrophy (LVH), diastolic dysfunction and left ventricular ejection fraction (EF)...
2016: PloS One
https://www.readbyqxmd.com/read/27701488/xanthine-oxidase-inhibitors-in-ischaemic-heart-disease
#20
Mihnea Zdrenghea, Adela Sitar-Tăut, Gabriel Cismaru, Dumitru Zdrenghea, Dana Pop
Increased uric acid levels are correlated with cardiovascular disease, particularly with ischaemic heart disease. Xanthine oxidase inhibitors, especially allopurinol, lower the risk of ischaemic heart disease due to their effects on reactive oxygen species and endothelial function. In chronic stable angina pectoris, allopurinol increases the median time to ST depression, time to chest pain, and total exercise time. On the other hand, it has been reported that allopurinol has a beneficial effect on ischaemic patients referred for angioplasty, but there are insufficient data regarding its effect on acute myocardial infarction patients...
September 9, 2016: Cardiovascular Journal of Africa
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