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https://www.readbyqxmd.com/read/29777889/endovascular-management-of-a-ruptured-basilar-perforator-artery-aneurysm-associated-with-a-pontine-arteriovenous-malformation-a-case-report-and-review-of-the-literature
#1
Joseph Lockwood, Tyler Scullen, Mansour Mathkour, Ascher Kaufmann, Ricky Medel, Aaron S Dumont, Peter S Amenta
BACKGROUND: Arteriovenous malformation (AVM)-associated aneurysms are common, being reported in 15% of cases. In regards to ruptured posterior fossa AVMs, associated aneurysms are present in 48% of cases and are the etiology of the bleed in 37%. We present a 75 year-old female who presented with a subarachnoid hemorrhage (SAH) secondary to a ruptured aneurysm arising from a flow-related basilar perforator artery feeder of an anterior pontine AVM. We report the successful treatment of the aneurysm with coil embolization...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29772363/a-comprehensive-study-of-symptomatic-late-radiation-induced-complications-after-radiosurgery-for-brain-arteriovenous-malformation-incidence-risk-factors-and-clinical-outcomes
#2
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Takehiro Sugiyama, Mariko Kawashima, Wataru Takahashi, Masaaki Shojima, Osamu Ishikawa, Hirofumi Nakatomi, Nobuhito Saito
OBJECT: Stereotactic radiosurgery (SRS) is widely used to treat brain arteriovenous malformation (AVM); however, detailed information on late radiation-induced complications (LRICs) is scarce. The goal of the present study was to characterize the incidence, risk factors, and clinical outcomes of LRICs based on our long-term follow-up data. METHODS: The outcomes of consecutive patients who underwent SRS for AVMs at our institution in 1990-2010 were analyzed. Cyst formation/encapsulated hematoma (CF/EH) and radiation-induced tumor (RIT) were defined as LRICs...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29769453/comparison-of-the-long-term-efficacy-and-safety-of-gamma-knife-radiosurgery-for-arteriovenous-malformations-in-pediatric-and-adult-patients
#3
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Mariko Kawashima, Wataru Takahashi, Osamu Ishikawa, Satoshi Koizumi, Hirofumi Nakatomi, Nobuhito Saito
It is debated whether the efficacy and long-term safety of gamma knife radiosurgery (GKRS) for arteriovenous malformations (AVMs) differs between adult and pediatric patients. We aimed to clarify the long-term outcomes of GKRS in pediatric patients and how they compare to those in adult patients. We collected data for 736 consecutive patients with AVMs treated with GKRS between 1990 and 2014 and divided the patients into pediatric (age < 20 years, n = 144) and adult (age ≥ 20 years, n = 592) cohorts. The mean follow-up period in the pediatric cohort was 130 months...
May 17, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29762746/microsurgery-versus-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-matched-cohort-study
#4
Ching-Jen Chen, Dale Ding, Tony R Wang, Thomas J Buell, Adeel Ilyas, Natasha Ironside, Cheng-Chia Lee, M Yashar Kalani, Min S Park, Kenneth C Liu, Jason P Sheehan
BACKGROUND: Microsurgery (MS) and stereotactic radiosurgery (SRS) remain the preferred interventions for the curative treatment of brain arteriovenous malformations (AVM), but their relative efficacy remains incompletely defined. OBJECTIVE: To compare the outcomes of MS to SRS for AVMs through a retrospective, matched cohort study. METHODS: We evaluated institutional databases of AVM patients who underwent MS and SRS. MS-treated patients were matched, in a 1:1 ratio based on patient and AVM characteristics, to SRS-treated patients...
May 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29759670/systemic-octreotide-therapy-in-prevention-of-gastrointestinal-bleeds-related-to-arteriovenous-malformations-and-obscure-etiology-in-atrial-fibrillation
#5
Venkat Vuddanda, Mohammad-Ali Jazayeri, Mohit K Turagam, Madhav Lavu, Valay Parikh, Donita Atkins, Sudharani Bommana, Madhu Reddy Yeruva, Luigi Di Biase, Jie Cheng, Vijay Swarup, Rakesh Gopinathannair, Mojtaba Olyaee, Vijay Ivaturi, Andrea Natale, Dhanunjaya Lakkireddy
OBJECTIVES: The present study describes the use of octreotide (OCT) in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) who have gastrointestinal (GI) bleeding related to arteriovenous malformations (AVMs), as well as its effect on OAC tolerance and subsequent rebleeding. BACKGROUND: AVMs cause significant GI bleeding, especially in patients with AF who are receiving OAC for stroke prevention. OCT has been shown to minimize recurrent GI bleeds related to AVMs...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29752992/radiosurgery-reduces-plasma-levels-of-angiogenic-factors-in-brain-arteriovenous-malformation-patients
#6
Ming Xu, Xiaoxia Liu, Guanghai Mei, Junjie Zhang, Weixing Wang, Hongzhi Xu
PURPOSE: Aberrant expression of angiogenic factors has been anecdotally documented in brain arteriovenous malformation (AVM) nidus vessels; however, no data is available on the effect of radiosurgery on the levels of angiogenic factors in AVM patients. We sought to determine the plasma contents of VEGF, TGF-β, Ang-2 and bFGF in 28 brain AVM patients at baseline and post radiosurgery and further analyzed the relationship between plasma contents of these angiogenic factors with clinicopathologic variables of these patients...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29752186/midterm-and-long-term-results-of-ethanol-embolization-of-auricular-arteriovenous-malformations-as-first-line-therapy
#7
Chen Hua, Yunbo Jin, Xi Yang, Yun Zou, Tianyou Wang, Hao Gu, Congzhen Qiao, Zimin Zhang, Xiaoxi Lin
OBJECTIVE: The objective of this study was to assess the midterm and long-term results of patients with auricular arteriovenous malformations (AVMs) treated by ethanol embolization. METHODS: Medical records of 35 patients (20 male, 15 female; age range, 10-59 years) with auricular AVMs between 2006 and 2016 were reviewed. The short-term results of 4 of the 35 patients were reported in 2009. They were included in this study with updated follow-up data. The data from the 31 new included patients have not been reported previously...
May 8, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29751183/onyx-embolization-before-the-surgical-treatment-of-grade-iii-spetzler-martin-brain-arteriovenous-malformations-single-center-experience-and-technical-nuances
#8
S Luzzi, M Del Maestro, D Bongetta, C Zoia, A V Giordano, D Trovarelli, Dehcordi S Raysi, R J Galzio
BACKGROUND: grade-III Spetzler-Martin (SM) brain arteriovenous malformations (AVMs) are a specific set of AVMs with a high variability in terms of site, size, angioarchitecture, flow dynamics and involvement of eloquent areas. Surgery preceded by pre-operative embolization has been reported as a useful treatment option for these lesions. The aim of this study is to report outcomes and personal experience of combined pre-operative Onyx embolization and surgical resection on a consecutive series of grade-III brain AVMs...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29750912/ras-signalling-in-energy-metabolism-and-rare-human-diseases
#9
REVIEW
L Dard, N Bellance, D Lacombe, R Rossignol
The RAS pathway is a highly conserved cascade of protein-protein interactions and phosphorylation that is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Recent findings indicate that the RAS pathway plays a role in the regulation of energy metabolism via the control of mitochondrial form and function but little is known on the participation of this effect in RAS-related rare human genetic diseases. Germline mutations that hyperactivate the RAS pathway have been discovered and linked to human developmental disorders that are known as RASopathies...
May 8, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29747435/the-use-of-transarterial-approaches-in-peripheral-arteriovenous-malformations-avms
#10
REVIEW
Aditya Khurana, Patrick T Hangge, Hassan Albadawi, M-Grace Knuttinen, Sadeer J Alzubaidi, Sailendra G Naidu, J Scott Kriegshauser, Rahmi Oklu, Brian W Chong
Arteriovenous malformations (AVMs) are a subset of congenital vascular malformations (CVMs). They comprise abnormal connections between arterial and venous circulation; treatment approaches are dependent on the angioarchitecture of the AVM, specifically the number and arrangement of the feeder arteries and outflow veins. Various imaging modalities can be used to diagnose and plan treatment. Here we will review the use of transarterial approaches to treat AVMs.
May 9, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29733392/the-application-of-the-novel-grading-scale-lawton-young-grading-system-to-predict-the-outcome-of-brain-arteriovenous-malformation
#11
Ahmad Hafez, Päivi Koroknay-Pál, Elias Oulasvirta, Ahmed Abou Elseoud, Michael T Lawton, Mika Niemelä, Aki Laakso
BACKGROUND: A supplementary grading scale (Supplemented Spetzler-Martin grade, Supp-SM) was introduced in 2010 as a refinement of the SM system to improve preoperative risk prediction of brain arteriovenous malformations (AVMs). OBJECTIVE: To determine the ability to predict surgical outcomes using the Supp-SM grading scale. METHODS: This retrospective study was conducted on 200 patients admitted to the Helsinki University Hospital between 2000 and 2014...
May 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29726773/letter-to-the-editor-volume-staged-vs-dose-staged-srs-for-large-brain-avms
#12
Zengpanpan Ye, Xiaolin Ai, Chao You
No abstract text is available yet for this article.
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29719554/pipeline-flex-embolization-of-flow-related-aneurysms-associated-with-arteriovenous-malformations-a-case-report
#13
Narlin B Beaty, Jessica K Campos, Geoffrey P Colby, Li-Mei Lin, Matthew T Bender, Risheng Xu, Alexander L Coon
Background: An estimated 0.1% of the population harbors brain arteriovenous malformations (AVMs). Diagnosis and workup of AVMs include thorough evaluation for characterization of AVM angioarchitecture and careful assessment for concomitant aneurysms. The presence of coexisting aneurysms is associated with an increased risk of intracranial hemorrhage, with a published risk of 7% per year compared to patients with AVMs alone with a risk of 3%. Comprehensive AVM management requires recognition of concomitant aneurysms and prioritizes treatment strategies to mitigate the aggregate risk of intracranial hemorrhage associated with AVM rupture in patients with coexisting aneurysms...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29718388/the-use-of-hypofractionated-radiosurgery-for-the-treatment-of-intracranial-lesions-unsuitable-for-single-fraction-radiosurgery
#14
Jim Zhong, Robert H Press, Jeffrey J Olson, Nelson M Oyesiku, Hui-Kuo G Shu, Bree R Eaton
Stereotactic radiosurgery (SRS) is commonly used in the treatment of brain metastases, benign tumors, and arteriovenous malformations (AVM). Single-fraction radiosurgery, though ubiquitous, is limited by lesion size and location. In these cases, hypofractionated radiosurgery (hfSRS) offers comparable efficacy and toxicity. We review the recent literature concerning hfSRS in the treatment of brain metastases, benign tumors, and AVMs that are poorly suited for single-fraction SRS. Published retrospective analyses suggest that local control rates for brain metastases and benign tumors, as well as the rates of AVM obliteration, following hfSRS treatment are comparable to those reported for single-fraction SRS...
April 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29685412/posterior-fossa-avms-increased-risk-of-bleeding-and-worse-outcome-compared-to-supratentorial-avms
#15
Nazife Dinc, Johannes Platz, Stephanie Tritt, Johanna Quick-Weller, Michael Eibach, Robert Wolff, Joachim Berkefeld, Volker Seifert, Gerhard Marquardt
Infratentorial AVMs are often considered as potentially hazardous as they are thought to present more often with hemorrhage, may harbor AVM-associated aneurysms more frequently and to be associated with poor outcome. The aim of our study is to compare features of supratentorial and infratentorial AVMs. We retrospectively analyzed 316 consecutive patients with cerebral AVM presenting to our neurovascular center between 2005 and 2015. Location and angioarchitecture of the AVM including AVM-associated aneurysms, bleeding events, and outcome during follow up were analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29680750/complete-resection-of-hypervascularised-extraventricular-neurocytoma-after-preoperative-embolisation
#16
Majed Katati, Isabel García, Clara Isabel Chamorro, Ángel Horcajadas, Alicia Hurtado, Carlos Sánchez, Benjamín Iañez, Enrique Saura, Ernesto García, Heriberto Busquier
A 13-year-old female arrived at the Emergency Department with a two-week history of headache, and bilateral papilloedema on examination. The initial study with CT and MRI showed a large multicystic left frontal mass with calcification surrounded by peripheral oedema, subacute intralesional bleeding and association of multiple large vessels. She was initially operated on in another centre where a subacute haematoma was found, evacuating to multiple vessels and arteriolised veins. Despite the earlier neuroimaging findings, arteriovenous malformation (AVM) was suspected, so she was referred to our centre for further treatment...
April 18, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29676692/letter-to-the-editor-cyst-formation-after-stereotactic-radiosurgery-for-brain-avms
#17
Zengpanpan Ye, Xiaolin Ai, Chao You
No abstract text is available yet for this article.
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675895/at-vessel-mortality-of-skates-rajidae-taken-in-coastal-fisheries-and-evidence-of-longer-term-survival
#18
J R Ellis, G J Burt, G Grilli, S R McCully Phillips, T L Catchpole, D L Maxwell
Data on the vigour and at-vessel mortality (AVM) of 6798 skates (comprising Raja clavata n = 6295; R. brachyura n = 208; R. undulata n = 185, R. montagui n = 98 and R. microocellata n = 12) captured by commercial fishing vessels in the inshore waters of the southern North Sea and English Channel were recorded. AVM in longline fisheries averaged 0·44% across five vessels (0-1·47%), although skates were usually unhooked manually and did not usually pass through a bait-stripper. AVM in otter trawls averaged 0·76% (0-2·35%), from four vessels fishing with tow durations of <1·5 h (southern North Sea) or 1-4 h (English Channel)...
April 19, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29675718/ultrasound-guided-brain-surgery-echographic-visibility-of-different-pathologies-and-surgical-applications-in-neurosurgical-routine
#19
Domenico Policicchio, Artan Doda, Enrico Sgaramella, Stefano Ticca, Filippo Veneziani Santonio, Riccardo Boccaletti
BACKGROUND: The use of intraoperative ultrasound (iUS) has increased in the last 15 years becoming a standard tool in many neurosurgical centers. Our aim was to assess the utility of routine use of iUS during various types of intracranial surgery. We reviewed our series to assess ultrasound visibility of different pathologies and iUS applications during the course of surgery. MATERIALS AND METHODS: This is a retrospective review of 162 patients who underwent intracranial surgery with assistance of the iUS guidance system (SonoWand)...
April 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29660051/resection-of-right-frontal-arteriovenous-malformation-3-dimensional-operative-video
#20
William T Couldwell
The video demonstrates resection of a Grade II Spetzler-Martin unruptured, medium-sized arteriovenous malformation (AVM). A young woman presented with headaches and seizures. The right frontal lesion measured 4.5 cm in largest dimension and had superficial venous drainage. Partial Onyx embolization, primarily of the anterior cerebral feeding arteries, was performed. Bone removal for exposure allowed identification of indentation from the large superficial draining vein. The video demonstrates careful microsurgical dissection on the AVM/brain interface, with selective interruption of feeding arteries circumferentially...
April 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
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