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https://www.readbyqxmd.com/read/28917252/stereotactic-radiosurgery-of-the-brain-a-review-of-common-indications
#1
Philip Gilbo, Isabella Zhang, Jonathan Knisely
Over the past half-century since Lars Leksell first utilized radiation to address deep and difficult to treat lesions of the central nervous system (CNS), intracranial stereotactic radiosurgery (SRS) has become an increasingly valued tool in the hands of neurosurgeons and radiation oncologists. Following developments in medical imaging and radiation technology, radiosurgery has evolved from its first application in movement disorders to widespread use for a varied range of malignant and benign conditions. SRS remains a powerful, minimally invasive instrument that offers additional options for intervention to a diverse patient population...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28914868/-combination-treatment-of-cerebral-arteriovenous-malformations-using-endovascular-and-microsurgical-techniques
#2
D M Galaktionov, A V Dubovoy, V S Kiselev, A O Sosnov, K S Ovsyannikov, A M Perfil'ev, A V Cherepanov
MATERIAL AND METHODS: The study included 40 patients with cerebral AVMs. In the study group, 14 (35%) patients underwent microsurgical resection without preliminary embolization (1st group), and 26 (65%) patients underwent combined treatment (endovascular embolization and microsurgical intervention, 2nd group). The first group included patients with S&M grade I-III AVMs, and the second group included patients with S&M grade II-V AVMs. Treatment outcomes were evaluated with allowance for completeness of AVM resection, operative blood loss, duration of surgery, changes in clinical and neurological impairments according to the modified Rankin scale, and rate of neurological and surgical complications...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28906387/a-nearly-full-recovery-from-avm-hemorrhagic-stroke-17-years-after-insult-using-a-new-integrated-neurodevelopmental-approach-a-case-report
#3
Alberto J Friedmann
RATIONAL: With the prevalence of stroke increasing in the USA and the world along with increased survival and longevity due to medical advancements, it has become increasingly necessary to look at the chronic phase of stroke recovery. Previous paradigms of stroke treatment have proven ineffective when looking at 10, 15, or 20 years of survival post insult. PATIENT CONCERNS: The patient, being a young man just out of high school, was concerned with his overall morbidity...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28901210/does-working-memory-impact-functional-outcomes-in-individuals-with-adhd-a-qualitative-and-comprehensive-literature-review
#4
Ronna Fried, Jessica Abrams, Anna Hall, Leah Feinberg, Amanda Pope, Joseph Biederman
OBJECTIVE: Working Memory (WM) is a domain of executive functioning often impaired in individuals with ADHD. Although assumed to cause difficulties across functioning, the scope of impairments from WM deficits in ADHD has not been investigated. The aim of this study was to examine outcomes associated with WM deficits in ADHD. METHOD: We conducted a search of the scientific literature on WM deficits, and Freedom From Distractibility (FFD), in ADHD using PubMed and PsycInfo databases...
September 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28894970/timing-of-surgery-for-ruptured-supratentorial-arteriovenous-malformations
#5
Ahmad Hafez, Elias Oulasvirta, Päivi Koroknay-Pál, Mika Niemelä, Juha Hernesniemi, Aki Laakso
BACKGROUND: There are conflicting opinions regarding the optimal waiting time to perform surgery after rupture of supratentorial arteriovenous malformations (AVMs) to achieve the best possible outcome. OBJECTIVE: To analyze factors influencing outcomes for ruptured supratentorial AVMs after surgery, paying particular attention to the timing of the surgery. METHODS: We retrospectively investigated 59 patients admitted to our center between 2000 and 2014 for surgical treatment of ruptured supratentorial AVMs...
September 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28893128/urticarial-reaction-following-endovascular-embolization-of-an-orbital-arteriovenous-malformation-avm-with-n-butyl-cyanoacrylate-nbca-glue
#6
Kunal R Sinha, Gary Duckwiler, Daniel B Rootman
Orbital arteriovenous malformations (AVMs) are rare vascular lesions that may be managed with endovascular embolization followed by surgical resection. Embolization is often accomplished with n-butyl-2-cyanoacrylate (nBCA), which is considered to be a safe and effective liquid occlusive agent. Localized vascular inflammation has been associated with endovascular nBCA use in histopathologic studies, but reports of systemic hypersensitivity reactions following endovascular embolization with nBCA are rare. We present a case of a 26-year-old male who developed an intermittent systemic urticarial reaction without cardiopulmonary compromise beginning four weeks after nBCA embolization of an orbital AVM...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28893127/successful-presurgical-endovascular-management-of-venous-sinus-thrombosis-associated-with-high-grade-cerebral-arteriovenous-malformation-a-case-report
#7
Yoshinari Osada, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Toshiki Endo, Miki Fujimura, Teiji Tominaga
We report a case of a 39-year-old man presenting with a high-grade left parieto-occipital arteriovenous malformation (AVM) complicated by superior sagittal sinus (SSS) stenosis, seven years after the first presentation. Magnetic resonance imaging revealed a newly developed perilesional edema. Venous sinus stenosis acutely progressed to occlusion and induced multiple intracerebral hemorrhages. An emergent balloon venoplasty of the SSS successfully recanalized the thrombosed sinus. Further, multistage transarterial nidus embolization was performed followed by surgical resection, resulting in a complete eradication of the large AVM...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28890056/giant-chest-wall-arteriovenous-malformation-a-case-report-and-literature-review
#8
Cullen McCarthy, Subrato Deb, Suhair Maqusi, Joshua Gierman
INTRODUCTION: We present an interesting case of a 55 year-old male with a large left chest mass after significant cutaneous bleeding. CT angiogram of the chest revealed arteriovenous malformation with blood supply from subbranches of the left subclavian artery, left internal mammary artery and left external carotid artery. Measuring 5.0x14.0x10.8cm, the mass extended superior to the clavicle and inferior to the third rib with medial and lateral borders at the level of the clavicular head and coracoid, respectively...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28890009/impact-of-onyx%C3%A2-embolization-on-radiosurgical-management-of-cerebral-avm-treatment-and-outcome
#9
Ido Strauss, Oz Haim, Daniel Umansky, Benjamin W Corn, Vladimir Frolov, Natan Shtraus, Shimon Maimon, Andrew A Kanner
BACKGROUND: Stereotactic radiosurgery (SRS) is a well-established treatment modality for cerebral arterio-venous malformations (AVMs). The main limiting factor in the radiosurgical treatment of AVMs is the volume of the nidus with high-grade lesions often requiring combined treatment to reduce the SRS target volume. To overcome this limitation, we have been using a combined treatment approach consisting of endovascular embolization with ONYX followed by SRS. OBJECTIVE: To evaluate our clinical experience for safety and feasibility of this multimodality treatment approach...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28885203/vascular-malformations-of-upper-and-lower-extremity-from-radiological-interventional-therapy-to-surgical-soft-tissue-reconstruction-an-interdisciplinary-treatment
#10
M Ranieri, W Wohlgemuth, R Müller-Wille, L Prantl, A Kehrer, S Geis, S Klein, P Lamby, D Schiltz, W Uller, T Aung, J H Dolderer
This article presents our experience in managing peripheral vascular malformations over a 4-years period in a series of 46 patients treated in our Interdisciplinary Center of Vascular Anomalies at University of Regensburg. The patients presented vascular malformations of upper and lower extremity and were selected from our prospective vascular anomalies file archive from 2012 to 2016.The purpose of this study was to review combined embolotherapy, sclerotherapy (embolo/sclerotherapy), and surgical procedures (surgical excision and soft tissue reconstruction) to manage vascular malformations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28885118/stereotactic-radiosurgery-for-spetzler-martin-grade-iv-and-v-arteriovenous-malformations-an-international-multicenter-study
#11
Mohana Rao Patibandla, Dale Ding, Hideyuki Kano, Zhiyuan Xu, John Y K Lee, David Mathieu, Jamie Whitesell, John T Pierce, Paul P Huang, Douglas Kondziolka, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Symeon Missios, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Due to the complexity of Spetzler-Martin (SM) Grade IV-V arteriovenous malformations (AVMs), the management of these lesions remains controversial. The aims of this multicenter, retrospective cohort study were to evaluate the outcomes after single-session stereotactic radiosurgery (SRS) for SM Grade IV-V AVMs and determine predictive factors. METHODS The authors retrospectively pooled data from 233 patients (mean age 33 years) with SM Grade IV (94.4%) or V AVMs (5.6%) treated with single-session SRS at 8 participating centers in the International Gamma Knife Research Foundation...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28881037/comparison-of-vessel-enhancement-algorithms-applied-to-time-of-flight-mra-images-for-cerebrovascular-segmentation
#12
Renzo Phellan, Nils D Forkert
PURPOSE: Vessel enhancement algorithms are often used as a preprocessing step for vessel segmentation in medical images to improve the overall segmentation accuracy. Each algorithm uses different characteristics to enhance vessels, such that the most suitable algorithm may vary for different applications. This paper presents a comparative analysis of the accuracy gains in vessel segmentation generated by the use of nine vessel enhancement algorithms: Multiscale vesselness using the formulas described by Erdt (MSE), Frangi (MSF), and Sato (MSS), optimally oriented ux (OOF), ranking orientations responses path operator (RORPO), the regularized Perona-Malik approach (RPM), vessel enhanced diffusion (VED), hybrid diffusion with continuous switch (HDCS), and the white top hat algorithm (WTH)...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28878048/functional-impairments-for-outcomes-in-a-randomized-trial-of-unruptured-brain-avms
#13
J P Mohr, Jessica R Overbey, Ruediger von Kummer, Marco A Stefani, Richard Libman, Christian Stapf, Michael K Parides, John Pile-Spellman, Ellen Moquete, Claudia S Moy, Eric Vicaut, Alan J Moskowitz, Kirsty Harkness, Charlotte Cordonnier, Alessandra Biondi, Emmanuel Houdart, Joachim Berkefeld, Karin J M Klijn, Xavier Barreau, Helen Kim, Andreas Hartmann
OBJECTIVE: To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA). METHODS: We used the initial results of a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years of age with an unruptured brain arteriovenous malformation (AVM) to compare the effects of medical management (MM) with or without interventional therapy (IT) on functional impairment, defined by a primary outcome of death or symptomatic stroke causing modified Rankin Scale (mRS) score ≥2...
September 6, 2017: Neurology
https://www.readbyqxmd.com/read/28871374/clinical-outcomes-and-radiosurgical-considerations-for-pediatric-arteriovenous-malformation-influence-of-clinical-features-on-obliteration-rate
#14
Chang Kyu Park, Seok Keun Choi, Sung Ho Lee, Man Kyu Choi, Young Jin Lim
PURPOSE: Gamma knife radiosurgery (GKRS) is an established treatment modality for brain arteriovenous malformation (AVM), but there have been few published studies examining the relationship between clinical features of AVM and successful obliteration with GKRS in pediatric patients. In the current study, we investigate the outcomes of GKRS for pediatric patients with brain AVM and analyze the variables that influence obliteration. METHODS: We analyzed 68 pediatric patients (≤ 18 years) with a mean follow-up period of 61...
September 4, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28871312/alk1-signaling-in-development-and-disease-new-paradigms
#15
REVIEW
Beth L Roman, Andrew P Hinck
Activin A receptor like type 1 (ALK1) is a transmembrane serine/threonine receptor kinase in the transforming growth factor-beta receptor family that is expressed on endothelial cells. Defects in ALK1 signaling cause the autosomal dominant vascular disorder, hereditary hemorrhagic telangiectasia (HHT), which is characterized by development of direct connections between arteries and veins, or arteriovenous malformations (AVMs). Although previous studies have implicated ALK1 in various aspects of sprouting angiogenesis, including tip/stalk cell selection, migration, and proliferation, recent work suggests an intriguing role for ALK1 in transducing a flow-based signal that governs directed endothelial cell migration within patent, perfused vessels...
September 4, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28862547/the-treatment-of-brain-avms-study-tobas-an-all-inclusive-framework-to-integrate-clinical-care-and-research
#16
Elsa Magro, Jean-Christophe Gentric, André Lima Batista, Marc Kotowski, Chiraz Chaalala, David Roberge, Alain Weill, Christian Stapf, Daniel Roy, Michel W Bojanowski, Tim E Darsaut, Ruby Klink, Jean Raymond
OBJECTIVE The management of brain arteriovenous malformations (bAVMs) remains controversial. The Treatment of Brain AVMs Study (TOBAS) was designed to manage patients with bAVMs within a clinical research framework. The objective of this study was to study trial feasibility, recruitment rates, patient allocation to the various management groups, and compliance with treatment allocation. METHODS TOBAS combines two randomized care trials (RCTs) and a registry. Designed to be all-inclusive, the study offers randomized allocation of interventional versus conservative management to patients eligible for both options (first RCT), a second RCT testing the role of preembolization as an adjunct to surgery or radiotherapy, and a registry of patients managed using clinical judgment alone...
September 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28857995/transarterial-embolization-and-transmucosal-sclerotherapy-that-led-to-successful-deliveries-in-a-patient-with-symptomatic-arteriovenous-malformation-of-the-tongue
#17
Munezumi Fujita, Yuhei Yamamoto, Satoru Sasaki, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa
Patients with arteriovenous malformations (AVMs) are at risk of significant hemorrhage and AVMs are especially difficult to manage in those desiring future pregnancy. Few patients with successful deliveries have been previously reported.The authors report an unusual case of AVM of the tongue in a pregnant woman who presented with massive pulsatile bleeding from a ruptured artery in the tongue in late gestation, this was thought to be caused by the changes in hormonal balance and the increase in cardiac output...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28855391/higher-flow-is-present-in-unruptured-arteriovenous-malformations-with-silent-intralesional-microhemorrhages
#18
Xiaolin Chen, Daniel L Cooke, David Saloner, Jeffrey Nelson, Hua Su, Michael T Lawton, Christopher Hess, Tarik Tihan, Yuanli Zhao, Helen Kim
BACKGROUND AND PURPOSE: Silent microhemorrhage (hemosiderin) has been observed in resected brain arteriovenous malformations (bAVM) tissue and may represent a subgroup at increased risk for clinical hemorrhage. Previous studies suggest that ruptured bAVMs have faster flow and shorter mean transit time of contrast in blood vessels than unruptured bAVMs. We hypothesized that flow would be faster in unruptured AVMs with hemosiderin compared with those without hemosiderin. METHODS: We selected unruptured, supratentorial bAVMs >3...
August 30, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28840423/hdlive-flow-silhouette-mode-for-the-diagnosis-of-uterine-enhanced-myometrial-vascularity-arteriovenous-malformations
#19
Chiaki Tenkumo, Kenji Kanenishi, Mohamed Ahmed Mostafa AboEllail, Kenta Yamamoto, Megumi Ishibashi, Nobuhiro Mori, Hirokazu Tanaka, Toshiyuki Hata
We present our initial experience of using the HDlive Flow silhouette mode to construct images of two cases of uterine enhanced myometrial vascularity/arteriovenous malformations (EMV/AVMs). In the first case, the HDlive Flow silhouette mode clearly depicted a fused vascular tumor with irregular contour in the posterior myometrium. In the second case, a large hypervascular mass occupying the entire fundal lesion of the uterus was clearly identified using the HDlive Flow silhouette mode. Moreover, spatial relationships among the hypervascular mass, intrauterine blood collection, and dilated, spiral-shaped right uterine artery enabled the clear localization of the mass...
August 24, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28840086/de-novo-arteriovenous-malformation-after-aneurysm-clipping
#20
Satoka Shidoh, Masahito Kobayashi, Kazunori Akaji, Tadashige Kano, Yoshio Tanizaki, Ban Mihara
We report a 73-year-old woman with de novo arteriovenous malformations (AVMs) that developed in the ipsilateral parietal lobe after craniotomy and aneurysm clipping. While intracerebral AVMs are considered to be congenital lesions, there have been several reported cases of acquired AVM arising after ischemic or traumatic episodes. We summarize previously reported cases of such acquired 'de novo' AVMs with a discussion of some pathophysiological responses or factors suggested to promote their development.
July 2017: NMC Case Rep J
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