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https://www.readbyqxmd.com/read/27920586/the-relation-between-sleep-and-weight-in-a-suburban-sleep-center-observations-and-speculations-on-apnea-and-weight
#1
Robert G Hooper
STUDY OBJECTIVES: The relationship between obstructive sleep apnea (OSA) and body weight is not clearly established. In order to describe the relationship of weight and OSA severity seen in a suburban sleep center, an observational review was performed of initial diagnostic polysomnograms (PSGs) ordered on patients with American Academy of Sleep Medicine (AASM) symptomatic indications. METHODOLOGY/PRINCIPLE FINDINGS: Initial, full-night diagnostic or initial split-night (diagnostic portion) PSGs performed for any indication on patients >18 years old were retrospectively reviewed for a two year period...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27919349/familial-combined-hyperlipidemia-and-hyperlipoprotein-a-as-phenotypic-mimics-of-familial-hypercholesterolemia-frequencies-associations-and-predictions
#2
Katrina L Ellis, Jing Pang, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Gerald F Watts
BACKGROUND: A significant proportion of index cases presenting with phenotypic familial hypercholesterolemia (FH) are not found to have a pathogenic mutation and may have other inherited conditions. OBJECTIVES: Familial combined hyperlipidemia (FCHL) and elevated lipoprotein(a) [Lp(a)] may mimic FH, but the frequency and correlates of these disorders among mutation-negative FH patients have yet to be established. METHODS: The frequency of FCHL and elevated Lp(a) was investigated in 206 FH mutation-negative index cases attending a specialist lipid clinic...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27900165/evaluation-of-cardiovascular-risk-lowering-health-benefits-accruing-from-laboratory-based-community-based-and-exercise-referral-exercise-programmes
#3
R Webb, J E S Thompson, J-S Ruffino, N A Davies, L Watkeys, S Hooper, P M Jones, G Walters, D Clayton, A W Thomas, K Morris, D H Llewellyn, M Ward, J Wyatt-Williams, B J McDonnell
BACKGROUND: To evaluate the ability of community-based exercise programmes to facilitate public participation in exercise and hence improved cardiovascular health, we assessed the respective impacts of: a continuously monitored exercise programme based within our university (study 1); a Valleys Regional Park-facilitated community-based outdoor exercise programme (study 2); a Wales National Exercise Referral Scheme-delivered exercise-referral programme (study 3). METHODS: Biomolecular (monocytic PPARγ target gene expression), vascular haemodynamic (central/peripheral blood pressure, arterial stiffness), clinical (insulin sensitivity, blood lipids) and anthropometric (body mass index, waist circumference, heart rate) parameters were investigated using RT-PCR, applanation tonometry, chemical analysis and standard anthropometric techniques...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27825992/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-adults-with-inhaled-corticosteroid-treated-asthma-in-london-uk
#4
REVIEW
David A Jolliffe, Kate Kilpin, Beverley D MacLaughlin, Claire L Greiller, Richard L Hooper, Neil C Barnes, Peter M Timms, Raj K Rajakulasingam, Angshu Bhowmik, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Christopher J Corrigan, Robert T Walton, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigating the prevalence, determinants and clinical correlates of vitamin D deficiency in adults with asthma are lacking. We conducted a multi-centre cross-sectional study in 297 adults with a medical record diagnosis of ICS-treated asthma living in London, UK. Details of potential environmental determinants of vitamin D status, asthma control and medication use were collected by questionnaire; blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction, and participants underwent measurement of weight, height and fractional exhaled nitric oxide concentration (FeNO), spirometry and sputum induction for determination of lower airway eosinophil counts (n=35 sub-group)...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27514941/adolescent-femoroacetabular-impingement-gender-differences-in-hip-morphology
#5
Perry Hooper, Sameer R Oak, T Sean Lynch, Gehan Ibrahim, Ryan Goodwin, James Rosneck
PURPOSE: To compare the hip morphology of adolescent male patients and female patients who underwent hip arthroscopy for femoroacetabular impingement (FAI) and determine if gender differences exist. METHODS: We retrospectively reviewed the records of 177 adolescents, aged 13 to 18 years, who were treated for FAI with hip arthroscopy. We examined and analyzed preoperative magnetic resonance imaging (MRI) scans and plain radiographs, measuring the lateral center-edge angle, Tönnis angle, and alpha angle...
August 8, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27436412/health-costs-of-reproduction-are-minimal-despite-high-fertility-mortality-and-subsistence-lifestyle
#6
Michael Gurven, Megan Costa, Ben Trumble, Jonathan Stieglitz, Bret Beheim, Daniel Eid Rodriguez, Paul L Hooper, Hillard Kaplan
Women exhibit greater morbidity than men despite higher life expectancy. An evolutionary life history framework predicts that energy invested in reproduction trades-off against investments in maintenance and survival. Direct costs of reproduction may therefore contribute to higher morbidity, especially for women given their greater direct energetic contributions to reproduction. We explore multiple indicators of somatic condition among Tsimane forager-horticulturalist women (Total Fertility Rate = 9.1; n =  592 aged 15-44 years, n = 277 aged 45+)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27344098/failure-of-antibiotics-in-cellulitis-trials-a-systematic-review-and-meta-analysis
#7
Itegbemie Obaitan, Richard Dwyer, Adam D Lipworth, Thomas S Kupper, Carlos A Camargo, David C Hooper, George F Murphy, Daniel J Pallin
OBJECTIVES: The objectives of the study are to quantify trial-to-trial variability in antibiotic failure rates, in randomized clinical trials of cellulitis treatment and to provide a point estimate for the treatment failure rate across trials. METHODS: We conducted a structured search for clinical trials evaluating antibiotic treatment of cellulitis, indexed in PubMed by August 2015. We included studies published in English and excluded studies conducted wholly outside of developed countries because the pathophysiology of cellulitis is likely to be different in such settings...
August 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27225436/water-loss-intracellular-dehydration-assessed-using-urinary-tests-how-well-do-they-work-diagnostic-accuracy-in-older-people
#8
Lee Hooper, Diane K Bunn, Asmaa Abdelhamid, Rachel Gillings, Amy Jennings, Katie Maas, Sophie Millar, Elizabeth Twomlow, Paul R Hunter, Lee Shepstone, John F Potter, Susan J Fairweather-Tait
BACKGROUND: Water-loss dehydration (hypertonic, hyperosmotic, or intracellular dehydration) is due to insufficient fluid intake and is distinct from hypovolemia due to excess fluid losses. Water-loss dehydration is associated with poor health outcomes such as disability and mortality in older people. Urine specific gravity (USG), urine color, and urine osmolality have been widely advocated for screening for dehydration in older adults. OBJECTIVE: We assessed the diagnostic accuracy of urinary measures to screen for water-loss dehydration in older people...
July 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27199287/progress-in-the-care-of-common-inherited-atherogenic-disorders-of-apolipoprotein-b-metabolism
#9
REVIEW
Katrina L Ellis, Amanda J Hooper, John R Burnett, Gerald F Watts
Familial hypercholesterolaemia, familial combined hyperlipidaemia (FCH) and elevated lipoprotein(a) are common, inherited disorders of apolipoprotein B metabolism that markedly accelerate the onset of atherosclerotic cardiovascular disease (ASCVD). These disorders are frequently encountered in clinical lipidology and need to be accurately identified and treated in both index patients and their family members, to prevent the development of premature ASCVD. The optimal screening strategies depend on the patterns of heritability for each condition...
August 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/26985134/impact-of-ramadan-intermittent-fasting-on-cognitive-function-in-trained-cyclists-a-pilot-study
#10
K Chamari, W Briki, A Farooq, T Patrick, T Belfekih, C P Herrera
This study assessed selected measures of cognitive function in trained cyclists who observed daylight fasting during Ramadan. Eleven cyclists volunteered to participate (age: 21.6±4.8 years, VO2max: 57.7±5.6 ml kg(-1)·min(-1)) and were followed for 2 months. Cognitive function (Cambridge Neuropsychological Test Automated Battery (CANTAB), Reaction Time index (RTI) and Rapid Visual Information Processing (RVP) tests) and sleep architecture (ambulatory EEG) were assessed: before Ramadan (BR), in the 1st week (RA1) and 4th week of Ramadan (RA4), and 2 weeks post-Ramadan (PR)...
March 2016: Biology of Sport
https://www.readbyqxmd.com/read/26903284/direct-observation-of-negative-index-microwave-surface-waves
#11
J A Dockrey, S A R Horsley, I R Hooper, J R Sambles, A P Hibbins
Waves propagating in a negative-index material have wave-front propagation (wavevector, k) opposite in direction to that of energy flow (Poynting vector, S). Here we present an experimental realisation at microwave frequencies of an analogous surface wave phenomenon whereby a metasurface supports a surface mode that has two possible wavevector eigenstates within a narrow band of frequencies: one that supports surface waves with positive mode index, and another that supports surface waves with negative mode index...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26556615/normocaloric-versus-hypocaloric-feeding-on-the-outcomes-of-icu-patients-a-systematic-review-and-meta-analysis
#12
Paul E Marik, Michael H Hooper
INTRODUCTION: Current clinical practice guidelines recommend providing ICU patients a daily caloric intake estimated to match 80-100 % of energy expenditure (normocaloric goals). However, recent clinical trials of intentional hypocaloric feeding question this approach. METHODS: We performed a systematic review and meta-analysis to compare the outcomes of ICU patients randomized to intentional hypocaloric or normocaloric goals. We included randomized controlled trials that enrolled ICU patients and compared intentional hypocaloric with normocaloric nutritional goals...
March 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26468938/executive-functioning-in-children-adolescents-and-young-adults-with-chronic-kidney-disease
#13
Stephen R Hooper, Nina Laney, Jerilynn Radcliffe, Divya Moodalbail, Erum A Hartung, Rebecca L Ruebner, Abbas F Jawad, Susan L Furth
OBJECTIVE: To compare behavior ratings of executive functioning in individuals with chronic kidney disease (CKD), using the Behavior Rating Inventory for Executive Functions (BRIEF), with a typically developing comparison group and to examine the correlation between disease severity and ratings of executive functioning. METHODS: Participants included 92 individuals with CKD (eGFR < 90 mL/min per 1.73 m), aged 8 to 25 years, recruited from nephrology clinics in both hospital and community settings...
November 2015: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/26373851/does-a-titanium-coated-polyethylene-press-fit-cup-give-reliable-midterm-results
#14
Nikki Hooper, Harry Sargeant, Chris Frampton, Gary Hooper
BACKGROUND: Uncemented acetabular components have demonstrated low revision rates and high patient satisfaction but with concerns regarding increased costs compared with monoblock cups. Some newer lower-cost uncemented monoblock options have become available in the last decade, but limited data are available on their performance. QUESTIONS/PURPOSES: (1) Does an uncemented, titanium-backed all-polyethylene acetabular cup provide reliable fixation? (2) What is the frequency and what are the causes for revision with this cup? METHODS: Between 2004 and 2008, we elected to use an uncemented, titanium-backed all-polyethylene acetabular cup in older patients with limited physical demands...
December 2015: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26278276/increase-in-pulmonary-blood-flow-at-birth-role-of-oxygen-and-lung-aeration
#15
Justin A R Lang, James T Pearson, Corinna Binder-Heschl, Megan J Wallace, Melissa L Siew, Marcus J Kitchen, Arjan B te Pas, Andreas Fouras, Robert A Lewis, Graeme R Polglase, Mikiyasu Shirai, Stuart B Hooper
Lung aeration stimulates the increase in pulmonary blood flow (PBF) at birth, but the spatial relationships between PBF and lung aeration and the role of increased oxygenation remain unclear. Using simultaneous phase-contrast X-ray imaging and angiography, we have investigated the separate roles of lung aeration and increased oxygenation in PBF changes at birth using near-term (30 days of gestation) rabbit kits (n = 18). Rabbits were imaged before ventilation, then the right lung was ventilated with 100% nitrogen (N2), air or 100% O2 (oxygen), before all kits were switched to ventilation in air, followed by ventilation of both lungs using air...
March 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26250104/effects-of-total-fat-intake-on-body-weight
#16
REVIEW
Lee Hooper, Asmaa Abdelhamid, Diane Bunn, Tracey Brown, Carolyn D Summerbell, C Murray Skeaff
BACKGROUND: In order to prevent overweight and obesity in the general population we need to understand the relationship between the proportion of energy from fat and resulting weight and body fatness in the general population. OBJECTIVES: To assess the effects of proportion of energy intake from fat on measures of weight and body fatness (including obesity, waist circumference and body mass index) in people not aiming to lose weight, using all appropriate randomised controlled trials (RCTs) and cohort studies in adults, children and young people SEARCH METHODS: We searched CENTRAL to March 2014 and MEDLINE, EMBASE and CINAHL to November 2014...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26068734/evaluating-quality-of-life-outcomes-following-joint-replacement-psychometric-evaluation-of-a-short-form-of-the-whoqol-bref
#17
Deborah L Snell, Richard J Siegert, Lois J Surgenor, Jennifer A Dunn, Gary J Hooper
PURPOSE: Reducing participant burden is important in health research and clinical assessment. We examined the psychometric properties of the EUROHIS-QOL 8-item index, a short version of the 26-item World Health Organisation Quality of Life questionnaire (WHOQOL-Bref), in a sample of people receiving joint replacement surgery. METHODS: Participants (n = 1008) completed the WHOQOL-Bref at either 6, 12, 24 or 60 months after hip or knee replacement. The factor structure, differential item functioning (DIF) and unidimensionality of the EUROHIS-QOL 8-item index were examined using exploratory and confirmatory factor analyses and Rasch analyses...
January 2016: Quality of Life Research
https://www.readbyqxmd.com/read/26067492/intensity-recovery-kinetics-and-well-being-indices-are-not-altered-during-an-official-fifa-futsal-tournament-in-oceanian-players
#18
Keyne Charlot, Paul Zongo, Anthony Scott Leicht, Olivier Hue, Olivier Galy
Physiological responses (intensity and recovery kinetics) and well-being indices were examined during a 4-day FIFA international tournament. Ten outfield New Caledonian players (age: 25.5 ± 3.8 years; height: 170 ± 7 cm; weight: 70.7 ± 8.6 kg) were assessed during the four matches. Players' aerobic and anaerobic capacities were measured before the tournament while heart rate (HR), intra-matches recovery and well-being indices (Hooper index) were measured throughout the tournament. HR (168 ± 8 bpm), exercise intensity (83...
2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/25924806/clinical-symptoms-signs-and-tests-for-identification-of-impending-and-current-water-loss-dehydration-in-older-people
#19
REVIEW
Lee Hooper, Asmaa Abdelhamid, Natalie J Attreed, Wayne W Campbell, Adam M Channell, Philippe Chassagne, Kennith R Culp, Stephen J Fletcher, Matthew B Fortes, Nigel Fuller, Phyllis M Gaspar, Daniel J Gilbert, Adam C Heathcote, Mohannad W Kafri, Fumiko Kajii, Gregor Lindner, Gary W Mack, Janet C Mentes, Paolo Merlani, Rowan A Needham, Marcel G M Olde Rikkert, Andreas Perren, James Powers, Sheila C Ranson, Patrick Ritz, Anne M Rowat, Fredrik Sjöstrand, Alexandra C Smith, Jodi J D Stookey, Nancy A Stotts, David R Thomas, Angela Vivanti, Bonnie J Wakefield, Nana Waldréus, Neil P Walsh, Sean Ward, John F Potter, Paul Hunter
BACKGROUND: There is evidence that water-loss dehydration is common in older people and associated with many causes of morbidity and mortality. However, it is unclear what clinical symptoms, signs and tests may be used to identify early dehydration in older people, so that support can be mobilised to improve hydration before health and well-being are compromised. OBJECTIVES: To determine the diagnostic accuracy of state (one time), minimally invasive clinical symptoms, signs and tests to be used as screening tests for detecting water-loss dehydration in older people by systematically reviewing studies that have measured a reference standard and at least one index test in people aged 65 years and over...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25871427/social-cognitive-training-in-adolescents-with-chromosome-22q11-2-deletion-syndrome-feasibility-and-preliminary-effects-of-the-intervention
#20
V Shashi, W Harrell, S Eack, C Sanders, A McConkie-Rosell, M S Keshavan, M J Bonner, K Schoch, S R Hooper
BACKGROUND: Children with chromosome 22q11.2 deletion syndrome (22q11DS) often have deficits in social cognition and social skills that contribute to poor adaptive functioning. These deficits may be of relevance to the later occurrence of serious psychiatric illnesses such as schizophrenia. Yet, there are no evidence-based interventions to improve social cognitive functioning in children with 22q11DS. METHODS: Using a customised social cognitive curriculum, we conducted a pilot small-group-based social cognitive training (SCT) programme in 13 adolescents with 22q11DS, relative to a control group of nine age- and gender-matched adolescents with 22q11DS...
October 2015: Journal of Intellectual Disability Research: JIDR
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