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https://www.readbyqxmd.com/read/29166696/-fluorescence-cholangiography-in-comparison-to-radiographic-cholangiography-during-laparoscopic-cholecystectomy
#1
Viktoria Pax, Sylke Schneider-Koriath, Martin Scholz, Reiko Wießner, Kaja Ludwig
Background The reported incidence rate of bile duct injury (BDI) during laparoscopic cholecystectomy (LC) is 0.3%. However, routine use of intraoperative cholangiography (IOC) is a controversial, due to the additional cost and radiation exposure. The aim of this study was to assess the application of fluorescence cholangiography (FC) in comparison to IOC and to LC without any intraoperative imaging. Materials and Methods This prospective study included 230 patients undergoing LC in our institution. The subjects were divided into two groups...
November 22, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29166549/depolymerization-of-poly-phosphinoboranes-from-polymers-to-lewis-base-stabilized-monomers
#2
Manfred Scheer, Christian Marquardt, Oliver Hegen, Ariane Vogel, Andreas Stauber, Michael Bodensteiner, Alexey Timoshkin
We report on depolymerization reactions of poly(phosphinoboranes). The cleavage of the polymers [H2PBH2]n (2a), [tBuHPBH2]n (2c), [PhHPBH2]n (2e) and the oligomer [Ph2PBH2]n (2b), with strong Lewis bases, in particular with NHCs, leads to the corresponding monomeric phosphanylboranes R1R2PBH2LB. It is observed that the depolymerization depends on the strength and stability of the LBs as well as on the substitution pattern of the poly(phosphinoboranes). The solid state structures of the monomeric phosphinoboranes H2PBH2NHCMe (NHC = N heterocyclic carbene) (4a), H2PBH2NHCdipp (5a) and tBuHPBH2NHCMe (4c) were determined...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29166493/dystrophic-calcification-of-maxillary-sinus-in-pediatric-patients-with-liver-transplantation-and-pigmentation-of-dental-organ
#3
Adriana Furtado de Macedo, Claudio Costa, Regina Helena Guedes da Motta Mattar, Ramiro Anthero de Azevedo
OBJECTIVE: To report a case of severe dystrophic calcification in maxillary sinus of a child with liver transplantation and dental organs pigmented by hyperbilirubinemia. CASE DESCRIPTION: female patient, 12 years old, with liver transplantation performed at the age of 7 due to extrahepatic biliary atresia (EHBA). The patient was receiving the immunosuppressant tacrolimus (2 mg daily). Intraoral clinical exam showed tooth green pigmentation by bilirubin. Cone-beam volumetric computed tomography (CT) was performed to verify radiographic density of pigmented dental elements...
November 17, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29166468/lafora-and-tr%C3%A3-tiakoff-the-naming-of-the-inclusion-bodies-discovered-by-lewy
#4
Eliasz Engelhardt
Fritz Heinrich Jakob Lewy described, for the first time, in 1912, novel peculiar inclusions in neurons of certain brain nuclei in patients with Paralysis agitans, and compared his finding to the amyloid bodies described by Lafora one year before. Gonzalo Rodriguez Lafora studied one patient with Paralysis agitans, in 1913, and recognized, described, and depicted structures identical to those previously reported by Lewy. He was the first to acknowledge Lewy's finding, and also the first to name such inclusions after the discoverer - cuerpos intracelulares de Lewy (Lewy bodies)...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166102/testing-the-limits-of-the-maxwell-distribution-of-velocities-for-atoms-flying-nearly-parallel-to-the-walls-of-a-thin-cell
#5
Petko Todorov, Daniel Bloch
For a gas at thermal equilibrium, it is usually assumed that the velocity distribution follows an isotropic 3-dimensional Maxwell-Boltzmann (M-B) law. This assumption classically implies the assumption of a "cos θ" law for the flux of atoms leaving the surface. Actually, such a law has no grounds in surface physics, and experimental tests of this assumption have remained very few. In a variety of recently developed sub-Doppler laser spectroscopy techniques for gases one-dimensionally confined in a thin cell, the specific contribution of atoms moving nearly parallel to the boundary of the vapor container becomes essential...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166074/low-lying-vibronic-level-structure-of-the-ground-state-of-the-methoxy-radical-slow-electron-velocity-map-imaging-sevi-spectra-and-k%C3%A3-ppel-domcke-cederbaum-kdc-vibronic-hamiltonian-calculations
#6
Marissa L Weichman, Lan Cheng, Jongjin B Kim, John F Stanton, Daniel M Neumark
A joint experimental and theoretical study is reported on the low-lying vibronic level structure of the ground state of the methoxy radical using slow photoelectron velocity-map imaging spectroscopy of cryogenically cooled, mass-selected anions (cryo-SEVI) and Köppel-Domcke-Cederbaum (KDC) vibronic Hamiltonian calculations. The KDC vibronic model Hamiltonian in the present study was parametrized using high-level quantum chemistry, allowing the assignment of the cryo-SEVI spectra for vibronic levels of CH3O up to 2000 cm(-1) and of CD3O up to 1500 cm(-1) above the vibrational origin, using calculated vibronic wave functions...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166046/fcc-hcp-coexistence-in-dense-thermo-responsive-microgel-crystals
#7
D Karthickeyan, R G Joshi, B V R Tata
Analogous to hard-sphere suspensions, monodisperse thermo-responsive poly (N-isopropyl acrylamide) (PNIPAM) microgel particles beyond a volume fraction (ϕ) of 0.5 freeze into face centered cubic (FCC)-hexagonal close packed (HCP) coexistence under as prepared conditions and into an FCC structure upon annealing. We report here FCC-HCP coexistence to be stable in dense PNIPAM microgel crystals (ϕ > 0.74) with particles in their deswollen state (referred to as osmotically compressed microgel crystals) and the FCC structure with particles in their swollen state by performing annealing studies with different cooling rates...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166002/structure-and-affinity-of-cu-i-bound-to-human-serum-albumin
#8
Madison Sendzik, M Jake Pushie, Ewelina Stefaniak, Kathryn L Haas
Human serum albumin (HSA) is a major Cu carrier in human blood and in cerebrospinal fluid. A major assumption is that Cu bound to HSA is in the Cu(II) oxidation state; thus, interactions between HSA and Cu(II) have been intensely investigated for over four decades. HSA has been reported previously to support the reduction of Cu(II) to the Cu(I) oxidation state in the presence of the weak reductant, ascorbate; however, the interactions between HSA and Cu(I) have not been explicitly investigated. Here, we characterize both the apparent affinity of HSA for Cu(I) using solution competition experiments and the coordination structure of Cu(I) bound to HSA using X-ray absorption spectroscopy and in silico modeling...
November 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29165980/controlled-insertion-of-planar-defect-in-inverse-opals-for-anti-counterfeiting-applications
#9
Yongjoon Heo, Su Yeon Lee, Ji-Won Kim, Tae Yoon Jeon, Shin-Hyun Kim
Inverse opals have been used for structural coloration and photonic applications owing to their photonic bandgap properties. When the photonic structures contain planar defects, they provide defect modes, which are useful for lasing, sensing, and waveguiding. However, it remains a challenge to insert a planar defect into inverse opals in a reproducible manner. Here, we report a new method for producing planar-defect-inserted inverse opals using sequential capillary wetting of colloidal crystals and creating micropatterns through photolithography...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165915/development-and-implementation-of-a-radiation-therapy-incident-learning-system-compatible-with-local-workflow-and-a-national-taxonomy
#10
Logan Montgomery, Palma Fava, Carolyn R Freeman, Tarek Hijal, Ciro Maietta, William Parker, John Kildea
PURPOSE: Collaborative incident learning initiatives in radiation therapy promise to improve and standardize the quality of care provided by participating institutions. However, the software interfaces provided with such initiatives must accommodate all participants and thus are not optimized for the workflows of individual radiation therapy centers. This article describes the development and implementation of a radiation therapy incident learning system that is optimized for a clinical workflow and uses the taxonomy of the Canadian National System for Incident Reporting - Radiation Treatment (NSIR-RT)...
November 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29165911/defects-and-interfaces-on-ptpb-nanoplates-boost-fuel-cell-electrocatalysis
#11
Yingjun Sun, Yanxia Liang, Mingchuan Luo, Fan Lv, Yingnan Qin, Lei Wang, Chuan Xu, Engang Fu, Shaojun Guo
Nanostructured Pt is the most efficient single-metal catalyst for fuel cell technology. Great efforts have been devoted to optimizing the Pt-based alloy nanocrystals with desired structure, composition, and shape for boosting the electrocatalytic activity. However, these well-known controls still show the limited ability in maximizing the Pt utilization efficiency for achieving more efficient fuel cell catalysis. Herein, a new strategy for maximizing the fuel cell catalysis by controlling/tuning the defects and interfaces of PtPb nanoplates using ion irradiation technique is reported...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29165869/canagliflozin-stability-study-and-eco-friendly-chromatographic-determination-of-its-degradation-product-a-comparative-study
#12
Aml A Emam
Canagliflozin is a newly approved drug for type II diabetes mellitus. A full stability study of Canagliflozin was performed following international conference on harmonization strategies. The drug was stable against all conditions except oxidation where only one degradation product was separated and structurally elucidated using mass spectrometry and IR spectroscopy. A green high-performance thin-layer chromatographic densitometric determination was developed and validated for the accurate quantification of Canagliflozin and its main oxidative degradation product...
November 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29165709/structural-basis-for-the-gtp-specificity-of-the-rna-kinase-domain-of-fungal-trna-ligase
#13
Barbara S Remus, Yehuda Goldgur, Stewart Shuman
Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2',3'-cyclic-PO4 and 5'-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase domains that heal the broken ends to generate the 3'-OH,2'-PO4 and 5'-PO4 termini required for sealing by an N-terminal ligase domain. Trl1 enzymes are found in all human fungal pathogens and are promising targets for antifungal drug discovery because their domain compositions and biochemical mechanisms are unique compared to the mammalian RtcB-type tRNA splicing enzyme...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165680/a-thermus-phage-protein-inhibits-host-rna-polymerase-by-preventing-template-dna-strand-loading-during-open-promoter-complex-formation
#14
Wei-Yang Ooi, Yuko Murayama, Vladimir Mekler, Leonid Minakhin, Konstantin Severinov, Shigeyuki Yokoyama, Shun-Ichi Sekine
RNA polymerase (RNAP) is a major target of gene regulation. Thermus thermophilus bacteriophage P23-45 encodes two RNAP binding proteins, gp39 and gp76, which shut off host gene transcription while allowing orderly transcription of phage genes. We previously reported the structure of the T. thermophilus RNAP•σA holoenzyme complexed with gp39. Here, we solved the structure of the RNAP•σA holoenzyme bound with both gp39 and gp76, which revealed an unprecedented inhibition mechanism by gp76. The acidic protein gp76 binds within the RNAP cleft and occupies the path of the template DNA strand at positions -11 to -4, relative to the transcription start site at +1...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165412/-stabilizing-effectiveness-of-orthokeratology-and-long-term-minute-concentration-atropine-therapy-in-myopia-draft-report
#15
T Yu Verzhanskaya, E P Tarutta
The rational for the study was the high prevalence of myopia in the world. According to the World Health Organization (WHO), myopia is one of the five leading causes of blindness and low vision. Of recent reports on conservative measures for the stabilization of myopia, two areas of investigation deserve attention: methods of optical correction that affect peripheral refraction, orthokeratology lenses (OKL) in particular, and pharmacotherapy. The aim of the study was to evaluate the effectiveness and safety of myopia control in pediatric patients by combining two methods - OKL wearing and instillation of extra low doses of atropine (0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165244/the-aaa-atpase-vps4-binds-escrt-iii-substrates-through-a-repeating-array-of-dipeptide-binding-pockets
#16
Han Han, Nicole Monroe, Wesley I Sundquist, Peter S Shen, Christopher P Hill
The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM structure (Monroe, Han et al. 2017), we now report a 3.2 Å structure of Vps4 bound to an ESCRT-III peptide substrate. The new structure reveals that the peptide approximates a b-strand conformation whose helical symmetry matches that of the five Vps4 subunits it contacts directly. Adjacent Vps4 subunits make equivalent interactions with successive substrate dipeptides through two distinct classes of side chain binding pockets formed primarily by Vps4 pore loop 1...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29165111/population-profile-and-residential-environment-of-an-urban-poor-community-in-dhaka-bangladesh
#17
Md Khalequzzaman, Chifa Chiang, Bilqis Amin Hoque, Sohel Reza Choudhury, Saika Nizam, Hiroshi Yatsuya, Akiko Matsuyama, Yoshihisa Hirakawa, Syed Shariful Islam, Hiroyasu Iso, Atsuko Aoyama
OBJECTIVES: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor. METHODS: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member...
March 14, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165099/recent-patents-and-formulation-of-nanopharmaceuticals-using-ultrasonication-technique
#18
Nidhi Saiwal, Mandeep Dahiya, Harish Dureja
BACKGROUND: Ultrasound (US) has the ever-rising role in the delivery of therapeutic agents that includes chemotherapeutic agents, proteins, and genetic material. The microbubbles are the cavitating gas bodies that act as the mediators through which the energy of relatively non-interactive pressure waves is accumulated to produce forces that can permeabilize cell membranes and disrupt the vesicles that carry the therapeutic agent. This shows that the microbubbles greatly enhance the delivery of smaller chemical agents, proteins and genetic material...
November 19, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/29165067/optimized-virtual-screening-workflow-towards-target-based-polynomial-scoring-functions-for-hiv-1-protease
#19
Val Oliveira Pintro, Walter F Azevedo
BACKGROUND: One key step in the development of inhibitors for an enzyme is the application of computational methodologies to predict protein-ligand interactions. The abundance of structural and ligand-binding information for HIV-1 protease opens up the possibility to apply computational methods to develop scoring functions targeted to this enzyme. OBJECTIVE: Our goal here is to develop an integrated molecular docking approach to investigate protein-ligand interactions with focus on the HIV-1 protease...
November 20, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29165051/a-structure-function-analysis-in-patients-with-prekallikrein-deficiency
#20
Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, Anna Maria Lombardi
OBJECTIVE: To investigate the structure-function relation in prekallikrein (PK) deficiency. PK is one of the proteins of the contact phase of blood coagulation which at the present time is the object of a revival of interest. METHODS: All patients with PK deficiency who had been investigated by molecular biology techniques are the object of the present investigation. Details of patients were obtained from personal files and a time-unlimited PubMed search. Only cases with a molecular-biology-based diagnosis were included...
November 22, 2017: Hematology (Amsterdam, Netherlands)
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