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metastatic esthesioneuroblastoma

Salma Moalla, Salma Gharbi, Chaouki Mbarki, Hajer Chennoufi, Saousen Melliti, Sana Mezghani Boussetta
No abstract text is available yet for this article.
May 20, 2018: Breast Journal
John P Marinelli, Jeffrey R Janus, Jamie J Van Gompel, Michael J Link, Robert L Foote, Christine M Lohse, Katharine A Price, Ashish V Chintakuntlawar
BACKGROUND: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. METHODS: We conducted a systematic review and meta-analysis. RESULTS: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P < .001). However, most patients (66%) received either monotherapy or no therapy...
May 13, 2018: Head & Neck
Yohji Matsusaka, Tadaki Nakahara, Isao Kurihara, Yu Iwabuchi, Masahiro Jinzaki
A 53-year-old woman with metastatic esthesioneuroblastoma was referred for FDG PET/CT imaging. FDG PET/CT showed symmetrical uptake in bilaterally enlarged adrenal glands, in addition to abnormal uptake in bone and lymph node metastases. In-pentetreotide scintigraphy was further performed and revealed the lack of adrenal uptake. The patient's serum adrenocorticotropic hormone (ACTH) level was extremely high, suggesting that hyperplastic condition in the adrenal glands due to ACTH stimulation from the metastatic esthesioneuroblastoma was responsible for increased FDG uptake...
June 2018: Clinical Nuclear Medicine
Sameer Alvi, Omar Karadaghy, Michelle Manalang, Robert Weatherly
OBJECTIVE: The purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms. STUDY DESIGN: Retrospective chart review of electronic medical record. SETTING: An academic, tertiary care pediatric hospital. SUBJECTS AND METHODS: IRB approval from the Office of Research Integrity at Children's Mercy Hospital was obtained...
June 2017: International Journal of Pediatric Otorhinolaryngology
Hee Cheol Jo, Seong Wook Lee, Hyun Joo Jung, Jun Eun Park
Neuroblastomas are sometimes associated with abnormal constitutional karyotypes, but the XYY karyotype has been rarely described in neuroblastomas. Here, we report a case of an esthesioneuroblastoma in a boy with a 47, XYY karyotype. A 6-year-old boy was admitted to our hospital because of nasal obstruction and palpable cervical lymph node, which he first noticed several days previously. A polypoid mass in the right nasal cavity was detected through sinuscopy. Biopsy of the right nasal polyp was performed. Based on the result, the patient was diagnosed with a high-grade esthesioneuroblastoma...
November 2016: Korean Journal of Pediatrics
Piotr Czapiewski, Michał Kunc, Johannes Haybaeck
Olfactory neuroblastoma (ONB, Esthesioneuroblastoma) is an infrequent neoplasm of the head and neck area derived from olfactory neuroepithelium. Despite relatively good prognosis a subset of patients shows recurrence, progression and/or metastatic disease, which requires additional treatment. However, neither prognostic nor predictive factors are well specified. Thus, we performed a literature search for the currently available data on disturbances in molecular pathways, cytogenetic changes and results gained by next generation sequencing (NGS) approaches in ONB in order to gain an overview of genetic alterations which might be useful for treating patients with ONB...
August 9, 2016: Oncotarget
Victoria E Banuchi, Laura Dooley, Nancy Y Lee, David G Pfister, Sean McBride, Nadeem Riaz, Mark H Bilsky, Ian Ganly, Jatin P Shah, Dennis H Kraus, Luc G T Morris
OBJECTIVES/HYPOTHESIS: To define the incidence and risk factors of metastatic disease and the effectiveness of salvage therapy in esthesioneuroblastoma (ENB). STUDY DESIGN: Retrospective analysis of 57 patients presenting from 1979 through 2009. METHODS: Cumulative incidence of neck failure, distant failure, and survival were assessed using the Kaplan-Meier method. RESULTS: Overall survival for all patients was 85% at 5 years and 75% at 10 years...
July 2016: Laryngoscope
Walavan Sivakumar, Nathan Oh, Aaron Cutler, Howard Colman, William T Couldwell
BACKGROUND: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. CASE DESCRIPTION: The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success...
2015: Surgical Neurology International
William Makis, Karey McCann, Alexander J B McEwan
A 51-year-old man with a recurrent metastatic esthesioneuroblastoma (olfactory neuroblastoma) was referred for peptide receptor radionuclide therapy (PRRT). He received 4 treatments of 111In-octreotide over 8 months and 3 treatments of 177Lu-DOTATATE over 4 months, which helped alleviate his symptoms and improved his quality of life; however, the tumor ultimately progressed and he passed away shortly thereafter. PRRT with 111In-octreotide or 177Lu-DOTATATE could play a role in the management of esthesioneuroblastoma...
April 2015: Clinical Nuclear Medicine
Jamie J Van Gompel, Michael J Link, Jason P Sheehan, Zhiyuan Xu, David Mathieu, Hideyuki Kano, L Dade Lunsford
Objective Esthesioneuroblastoma (ENB) is a rare malignant neuroendocrine neoplasm that is prone to both local and metastatic recurrence. Local recurrence may often be treated with repeat resection. However, stereotactic radiosurgery (SRS) offers a noninvasive option. Design Prospective database review. Participants Gamma knife prospective databases were queried at all institutions within the North American Gamma Knife Consortium, 16 at the time of this report. All patients who had undergone SRS for ENB were included...
December 2014: Journal of Neurological Surgery. Part B, Skull Base
Noppadol Larbcharoensub, Wasana Kanoksil, Wichit Cheewaruangroj, Cholatip Wiratkapun, Chomporn Sitathanee, Ekaphop Sirachainan
Metastasis to the breast from an extramammary malignant neoplasm, including esthesioneuroblastoma, is uncommon. The present study describes a rare case of sinonasal esthesioneuroblastoma, Hyams' histologic grade 2, Kadish's stage C, T4N0M0, in a 30-year-old female. The patient underwent a radical ethmoidectomy with external beam radiotherapy, followed by chemotherapy including five cycles of cisplatin and etoposide. One year after the initial diagnosis, the patient presented to the hospital with the chief complaint of a rapidly enlarging lump in the right breast...
October 2014: Oncology Letters
Diana Bell, Rami Saade, Dianna Roberts, Thomas J Ow, Michael Kupferman, Franco DeMonte, Ehab Y Hanna
Esthesioneuroblastoma (ENB) is derived from the specialized olfactory neuroepithelium. Hyams grading and Kadish staging have been used to prognosticate and to guide treatment decisions. In this study, we sought to validate the prognostic utility of these systems in a large ENB cohort. We retrospectively analyzed the records of patients with ENB who had been evaluated and treated at our institution. The association of grade and stage with prognostic outcome was assessed; the Kaplan-Meier estimator was used to generate 5-year OS and DFS curves...
March 2015: Head and Neck Pathology
Bruno D Fornage, Beth S Edeiken, Gary L Clayman
OBJECTIVE: The purpose of this article is to describe the use of transoral sonography in the diagnosis, fine-needle aspiration (FNA) biopsy, and intraoperative localization of retropharyngeal masses. MATERIALS AND METHODS: We reviewed images and data for eight patients with a retropharyngeal mass identified on CT, MRI, or PET/CT as being suspicious for a metastatic Rouviere node. Transoral ultrasound was performed using a commercially available endorectal or endovaginal transducer...
May 2014: AJR. American Journal of Roentgenology
Kenichi Tanaka, Yuka Yamamoto, Hiroshi Hoshikawa, Yoshihiro Nishiyama
Olfactory neuroblastoma is an uncommon malignant neoplasm of the superior nasal cavity. We report a case of a 78-year-old woman who presented with frontal headache and proptosis of the right eye. CT revealed a nasoethmoid mass with diffuse calcifications. FDG PET/CT demonstrated intense FDG uptake by a main nasoethmoid tumor and metastatic lesions in the cervical lymph nodes. Histologic examination confirmed olfactory neuroblastoma.
July 2014: Clinical Nuclear Medicine
Andreas Schröck, Friederike Göke, Patrick Wagner, Maike Bode, Alina Franzen, Sebastian Huss, Abbas Agaimy, Stephan Ihrler, Robert Kirsten, Glen Kristiansen, Friedrich Bootz, Claudia Lengerke, Sven Perner
BACKGROUND: Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. METHODS: One hundred twelve primary tumors (including squamous cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number status...
September 2014: Head & Neck
Ali S Shirzadi, Doniel G Drazin, Allison S Strickland, Serguei I Bannykh, J Patrick Johnson
Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient's disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection...
2013: Case Reports in Surgery
Josephine Akinfolarin, Tarek Jazaerly, Kia Jones, Maher Abu-Hamdan, Fulvio Lonardo, Adam Folbe, Tamar Giorgadze
Esthesioneuroblastoma (ENB) is a rare tumor derived from olfactory neuroepithelium. ENB in a site outside of where olfactory epithelium exists is exceedingly rare with only five cases of ENB isolated to the sphenoid sinuses described in the literature to date. To the best of our knowledge, a skin metastasis of ENB outside the head and neck region has not been reported. We present an unusual case of a 33-year-old male diagnosed with primary sphenoid sinus ENB, who underwent surgical resection of the tumor followed by chemoradiation...
January 2012: Avicenna Journal of Medicine
Fatma Elloumi, Noureddine Boujelbene, Lilia Ghorbal, Nadia Boujelbene, Khaouthar Khanfir, René-Olivier Mirimanoff, Jamel Daoud
Esthesioneuroblastoma is an uncommon malignancy originating from olfactive epithelium. Men are more frequently affected than women. Nasal symptoms are the most common revealing signs. Immunohistochemistry helps diagnosis. There is no randomized trial evaluating treatment due to the low incidence of this tumor. Radiotherapy and surgery are the standard of care. Radiotherapy is benefic even in early stage disease. Chemotherapy is indicated in case of locally advanced or metastatic disease.
December 2012: Bulletin du Cancer
Stephen M Broski, Christopher H Hunt, Geoffrey B Johnson, Ratham M Subramaniam, Patrick J Peller
UNLABELLED: The purpose of this study was to evaluate the clinical utility of (18)F-FDG PET/CT in esthesioneuroblastoma staging and restaging and quantify the additional benefit of PET/CT to conventional imaging. METHODS: A retrospective review was performed with institutional review board approval for patients with a diagnosis of esthesioneuroblastoma who underwent PET/CT from 2000 to 2010. PET/CT results were retrospectively reviewed by 2 radiologists who were unaware of the clinical and imaging data...
August 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Glen J Weiss, Winnie S Liang, Tyler Izatt, Shilpi Arora, Irene Cherni, Robert N Raju, Galen Hostetter, Ahmet Kurdoglu, Alexis Christoforides, Shripad Sinari, Angela S Baker, Raghu Metpally, Waibhav D Tembe, Lori Phillips, Daniel D Von Hoff, David W Craig, John D Carpten
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal tract with little molecular characterization. We performed whole genome sequencing (WGS) on paired normal and tumor DNA from a patient with metastatic-ONB to identify the somatic alterations that might be drivers of tumorigenesis and/or metastatic progression. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA was isolated from fresh frozen tissue from a metastatic lesion and whole blood, followed by WGS at >30X depth, alignment and mapping, and mutation analyses...
2012: PloS One
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