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metastatic esthesioneuroblastoma

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https://www.readbyqxmd.com/read/27256979/genetic-and-molecular-alterations-in-olfactory-neuroblastoma-implications-for-pathogenesis-prognosis-and-treatment
#1
Piotr Czapiewski, Michał Kunc, Johannes Haybaeck
Olfactory neuroblastoma (ONB, Esthesioneuroblastoma) is an infrequent neoplasm of the head and neck area derived from olfactory neuroepithelium. Despite relatively good prognosis a subset of patients shows recurrence, progression and/or metastatic disease, which requires additional treatment. However, neither prognostic nor predictive factors are well specified. Thus, we performed a literature search for the currently available data on disturbances in molecular pathways, cytogenetic changes and results gained by next generation sequencing (NGS) approaches in ONB in order to gain an overview of genetic alterations which might be useful for treating patients with ONB...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/26865537/patterns-of-regional-and-distant-metastasis-in-esthesioneuroblastoma
#2
Victoria E Banuchi, Laura Dooley, Nancy Y Lee, David G Pfister, Sean McBride, Nadeem Riaz, Mark H Bilsky, Ian Ganly, Jatin P Shah, Dennis H Kraus, Luc G T Morris
OBJECTIVES/HYPOTHESIS: To define the incidence and risk factors of metastatic disease and the effectiveness of salvage therapy in esthesioneuroblastoma (ENB). STUDY DESIGN: Retrospective analysis of 57 patients presenting from 1979 through 2009. METHODS: Cumulative incidence of neck failure, distant failure, and survival were assessed using the Kaplan-Meier method. RESULTS: Overall survival for all patients was 85% at 5 years and 75% at 10 years...
July 2016: Laryngoscope
https://www.readbyqxmd.com/read/26682087/cranial-and-spinal-leptomeningeal-dissemination-in-esthesioneuroblastoma-two-reports-of-distant-central-nervous-system-metastasis-and-rationale-for-treatment
#3
Walavan Sivakumar, Nathan Oh, Aaron Cutler, Howard Colman, William T Couldwell
BACKGROUND: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. CASE DESCRIPTION: The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/25674857/esthesioneuroblastoma-olfactory-neuroblastoma-treated-with-111in-octreotide-and-177lu-dotatate-prrt
#4
William Makis, Karey McCann, Alexander J B McEwan
A 51-year-old man with a recurrent metastatic esthesioneuroblastoma (olfactory neuroblastoma) was referred for peptide receptor radionuclide therapy (PRRT). He received 4 treatments of 111In-octreotide over 8 months and 3 treatments of 177Lu-DOTATATE over 4 months, which helped alleviate his symptoms and improved his quality of life; however, the tumor ultimately progressed and he passed away shortly thereafter. PRRT with 111In-octreotide or 177Lu-DOTATATE could play a role in the management of esthesioneuroblastoma...
April 2015: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/25452899/radiosurgery-is-an-effective-treatment-for-recurrent-esthesioneuroblastoma-a-multicenter-study
#5
Jamie J Van Gompel, Michael J Link, Jason P Sheehan, Zhiyuan Xu, David Mathieu, Hideyuki Kano, L Dade Lunsford
Objective Esthesioneuroblastoma (ENB) is a rare malignant neuroendocrine neoplasm that is prone to both local and metastatic recurrence. Local recurrence may often be treated with repeat resection. However, stereotactic radiosurgery (SRS) offers a noninvasive option. Design Prospective database review. Participants Gamma knife prospective databases were queried at all institutions within the North American Gamma Knife Consortium, 16 at the time of this report. All patients who had undergone SRS for ENB were included...
December 2014: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/25202357/esthesioneuroblastoma-metastasis-to-the-breast-a-case-report-and-review-of-the-literature
#6
Noppadol Larbcharoensub, Wasana Kanoksil, Wichit Cheewaruangroj, Cholatip Wiratkapun, Chomporn Sitathanee, Ekaphop Sirachainan
Metastasis to the breast from an extramammary malignant neoplasm, including esthesioneuroblastoma, is uncommon. The present study describes a rare case of sinonasal esthesioneuroblastoma, Hyams' histologic grade 2, Kadish's stage C, T4N0M0, in a 30-year-old female. The patient underwent a radical ethmoidectomy with external beam radiotherapy, followed by chemotherapy including five cycles of cisplatin and etoposide. One year after the initial diagnosis, the patient presented to the hospital with the chief complaint of a rapidly enlarging lump in the right breast...
October 2014: Oncology Letters
https://www.readbyqxmd.com/read/24806334/prognostic-utility-of-hyams-histological-grading-and-kadish-morita-staging-systems-for-esthesioneuroblastoma-outcomes
#7
Diana Bell, Rami Saade, Dianna Roberts, Thomas J Ow, Michael Kupferman, Franco DeMonte, Ehab Y Hanna
Esthesioneuroblastoma (ENB) is derived from the specialized olfactory neuroepithelium. Hyams grading and Kadish staging have been used to prognosticate and to guide treatment decisions. In this study, we sought to validate the prognostic utility of these systems in a large ENB cohort. We retrospectively analyzed the records of patients with ENB who had been evaluated and treated at our institution. The association of grade and stage with prognostic outcome was assessed; the Kaplan-Meier estimator was used to generate 5-year OS and DFS curves...
March 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/24758683/use-of-transoral-sonography-with-an-endocavitary-transducer-in-diagnosis-fine-needle-aspiration-biopsy-and-intraoperative-localization-of-retropharyngeal-masses
#8
Bruno D Fornage, Beth S Edeiken, Gary L Clayman
OBJECTIVE: The purpose of this article is to describe the use of transoral sonography in the diagnosis, fine-needle aspiration (FNA) biopsy, and intraoperative localization of retropharyngeal masses. MATERIALS AND METHODS: We reviewed images and data for eight patients with a retropharyngeal mass identified on CT, MRI, or PET/CT as being suspicious for a metastatic Rouviere node. Transoral ultrasound was performed using a commercially available endorectal or endovaginal transducer...
May 2014: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/24662664/a-case-of-olfactory-neuroblastoma-detected-by-18-f-fdg-pet-ct
#9
Kenichi Tanaka, Yuka Yamamoto, Hiroshi Hoshikawa, Yoshihiro Nishiyama
Olfactory neuroblastoma is an uncommon malignant neoplasm of the superior nasal cavity. We report a case of a 78-year-old woman who presented with frontal headache and proptosis of the right eye. CT revealed a nasoethmoid mass with diffuse calcifications. FDG PET/CT demonstrated intense FDG uptake by a main nasoethmoid tumor and metastatic lesions in the cervical lymph nodes. Histologic examination confirmed olfactory neuroblastoma.
July 2014: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/23913758/fibroblast-growth-factor-receptor-1-as-a-potential-therapeutic-target-in-sinonasal-cancer
#10
Andreas Schröck, Friederike Göke, Patrick Wagner, Maike Bode, Alina Franzen, Sebastian Huss, Abbas Agaimy, Stephan Ihrler, Robert Kirsten, Glen Kristiansen, Friedrich Bootz, Claudia Lengerke, Sven Perner
BACKGROUND: Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. METHODS: One hundred twelve primary tumors (including squamous cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number status...
September 2014: Head & Neck
https://www.readbyqxmd.com/read/23533909/vertebral-column-metastases-from-an-esthesioneuroblastoma-chemotherapy-radiation-and-resection-for-recurrence-with-15-year-followup
#11
Ali S Shirzadi, Doniel G Drazin, Allison S Strickland, Serguei I Bannykh, J Patrick Johnson
Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient's disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection...
2013: Case Reports in Surgery
https://www.readbyqxmd.com/read/23210016/fine-needle-aspiration-cytology-of-primary-sphenoid-sinus-esthesioneuroblastoma-metastatic-to-the-skin
#12
Josephine Akinfolarin, Tarek Jazaerly, Kia Jones, Maher Abu-Hamdan, Fulvio Lonardo, Adam Folbe, Tamar Giorgadze
Esthesioneuroblastoma (ENB) is a rare tumor derived from olfactory neuroepithelium. ENB in a site outside of where olfactory epithelium exists is exceedingly rare with only five cases of ENB isolated to the sphenoid sinuses described in the literature to date. To the best of our knowledge, a skin metastasis of ENB outside the head and neck region has not been reported. We present an unusual case of a 33-year-old male diagnosed with primary sphenoid sinus ENB, who underwent surgical resection of the tumor followed by chemoradiation...
January 2012: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/23022763/-esthesioneuroblastoma
#13
REVIEW
Fatma Elloumi, Noureddine Boujelbene, Lilia Ghorbal, Nadia Boujelbene, Khaouthar Khanfir, René-Olivier Mirimanoff, Jamel Daoud
Esthesioneuroblastoma is an uncommon malignancy originating from olfactive epithelium. Men are more frequently affected than women. Nasal symptoms are the most common revealing signs. Immunohistochemistry helps diagnosis. There is no randomized trial evaluating treatment due to the low incidence of this tumor. Radiotherapy and surgery are the standard of care. Radiotherapy is benefic even in early stage disease. Chemotherapy is indicated in case of locally advanced or metastatic disease.
December 2012: Bulletin du Cancer
https://www.readbyqxmd.com/read/22728262/the-added-value-of-18f-fdg-pet-ct-for-evaluation-of-patients-with-esthesioneuroblastoma
#14
Stephen M Broski, Christopher H Hunt, Geoffrey B Johnson, Ratham M Subramaniam, Patrick J Peller
UNLABELLED: The purpose of this study was to evaluate the clinical utility of (18)F-FDG PET/CT in esthesioneuroblastoma staging and restaging and quantify the additional benefit of PET/CT to conventional imaging. METHODS: A retrospective review was performed with institutional review board approval for patients with a diagnosis of esthesioneuroblastoma who underwent PET/CT from 2000 to 2010. PET/CT results were retrospectively reviewed by 2 radiologists who were unaware of the clinical and imaging data...
August 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/22649506/paired-tumor-and-normal-whole-genome-sequencing-of-metastatic-olfactory-neuroblastoma
#15
Glen J Weiss, Winnie S Liang, Tyler Izatt, Shilpi Arora, Irene Cherni, Robert N Raju, Galen Hostetter, Ahmet Kurdoglu, Alexis Christoforides, Shripad Sinari, Angela S Baker, Raghu Metpally, Waibhav D Tembe, Lori Phillips, Daniel D Von Hoff, David W Craig, John D Carpten
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal tract with little molecular characterization. We performed whole genome sequencing (WGS) on paired normal and tumor DNA from a patient with metastatic-ONB to identify the somatic alterations that might be drivers of tumorigenesis and/or metastatic progression. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA was isolated from fresh frozen tissue from a metastatic lesion and whole blood, followed by WGS at >30X depth, alignment and mapping, and mutation analyses...
2012: PloS One
https://www.readbyqxmd.com/read/22441001/bilateral-adrenalectomy-lifesaving-procedure-in-severe-cushing-syndrome
#16
Jennifer Y Han, Leili Mirsadraei, Michael W Yeh, Jeffrey D Suh, William H Yong, Marvin Bergsneider, Anthony P Heaney
OBJECTIVE: To discuss the role of bilateral adrenalectomy in Cushing syndrome, as illustrated in a case of severe hypercortisolism that was unresponsive to combination agent medical therapy. METHODS: We report the clinical, laboratory, imaging, and pathologic findings in a patient with ectopic Cushing syndrome attributable to an adrenocorticotropic hormone (ACTH)-secreting neuroblastoma. In addition, we provide a literature review regarding olfactory neuroblastoma and discuss current and emerging therapeutic options for Cushing syndrome...
July 2012: Endocrine Practice
https://www.readbyqxmd.com/read/21959469/metastatic-esthesioneuroblastoma-secreting-adrenocorticotropic-hormone-in-pediatric-patients
#17
REVIEW
Silvestre Galioto, Alessandro Di Petrillo, Mauro Pastori, Alberto Arecchi
The purpose of this article was to report a pediatric case of secondary cervical esthesioneuroblastoma involving the parapharyngeal lymph nodes. A 3-year-old boy came to our clinical observation because of a right lymphonodal mass evidenced by nuclear magnetic resonance and a diagnosis of Cushing syndrome associated with ectopic adrenocorticotropic hormone secretion, moon face, central obesity, asthenia, and hirsutism. At the age of 10 months, the patient underwent endoscopic surgery for asportation of the World Health Organization stage IV esthesioneuroblastoma...
September 2011: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/21913034/a-phase-i-study-of-daily-everolimus-plus-low-dose-weekly-cisplatin-for-patients-with-advanced-solid-tumors
#18
Matthew G Fury, Eric Sherman, Sofia Haque, Susan Korte, Donna Lisa, Ronglai Shen, Nian Wu, David Pfister
PURPOSE: Preclinical studies demonstrate synergistic anti-tumor activity with the combination of everolimus and cisplatin. We conducted a phase I study to establish the recommended phase II of oral everolimus to be given with low-dose weekly intravenous cisplatin. METHODS: Part A used a standard 3 + 3 dose escalation scheme. There were 4 planned dose levels of everolimus: 2.5, 5, 7.5, and 10 mg/day. Subjects received oral everolimus during days 1-21 and cisplatin 20 mg/m(2) intravenously (fixed dose) on days 1, 8, and 15 of a 28-day cycle...
March 2012: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/21752653/metastatic-olfactory-neuroblastoma-invading-a-radiation-induced-meningioma
#19
James Dimou, Ruth A Mitchell, Alpha Tsui, Bhadu Kavar, Andrew H Kaye
Olfactory neuroblastomas are malignant, neuroectodermal nasal tumours. We describe a 62-year-old patient with a recurrent olfactory neuroblastoma invading a radiation-induced meningioma. Given the temporal and spatial relationship between the primary lesion and the described recurrence, this was due to metastatic rather than direct contiguous spread, fulfilling all the criteria for true tumour-to-tumour metastasis. To our knowledge, this is the first description of an olfactory neuroblastoma metastasising to a meningioma...
September 2011: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/21519157/pathological-features-of-olfactory-neuroblastoma-in-an-axolotl-ambystoma-mexicanum
#20
Chieko Shioda, Kazuyuki Uchida, Hiroyuki Nakayama
A one-year-old, female Mexican axolotl (Ambystoma mexicanum) had a rough-surfaced, polypoid, pink tumor mass of approximately 10 mm in diameter in the oral cavity. Histologically, the tumor extended from the ethmoturbinate region and into the oral cavity and had replaced some of the maxillary bone tissue. The tumor mass was composed of a lobular architecture of small round-shaped tumor cells with occasional Flexner-Wintersteiner-like rosette formation. There were no metastatic lesions in the other organs. Immunohistochemically, the tumor cells were partly positive for several neural markers (class III beta-tubulin, S-100 protein, and doublecortin) and intensely positive for an epithelial marker (cytokeratin AE1/AE3)...
August 2011: Journal of Veterinary Medical Science
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