keyword
https://read.qxmd.com/read/38526915/treatment-of-unilateral-olfactory-neuroblastoma-appropriate-extent-of-surgical-resection-and-potential-for-olfactory-preservation
#1
JOURNAL ARTICLE
Harish Dharmarajan, Garret Choby, Ralph Abi Hachem, Edward C Kuan, Corinna G Levine, Olabisi Sanusi, Theodore Schuman, Dennis Tang, Michael Yim, Mathew Geltzeiler
Historically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a patient's quality of life without definitive added benefit in survival. The prevalence of occult intracranial disease is low, especially for Hyams grade I and II tumors. A unilateral approach sparing the contralateral cribriform plate and olfactory system can be considered for select cases of early stage, low-grade tumors when the disease does not cross midline to involve the contralateral olfactory cleft or septal mucosa and when midline dural margins can be cleared with frozen pathology...
March 25, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38520057/review-of-neoplasia-in-fish-at-a-large-display-aquarium-2005-2021
#2
JOURNAL ARTICLE
Sarah E Wright, Michael Pawlik, Heindrich N Snyman, Martin Haulena
Fish maintained in managed care may have longer lifespans as a result of advances in veterinary medicine and husbandry and reduced risk of predation. Neoplasia is of increasing interest in managed aquarium populations. However, few studies have systematically evaluated neoplasia in managed fish populations. Our objective in this retrospective study was to review and describe neoplasia diagnosed in fish at a large public display aquarium between 2005 and 2021. Any fish diagnosed with neoplasia on either antemortem or postmortem evaluation during the study period was included, and all medical records, biopsy, and autopsy reports were reviewed...
March 22, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38518294/patterns-of-recurrence-and-disease-progression-in-patients-with-positive-margin-olfactory-neuroblastoma-following-primary-resection
#3
JOURNAL ARTICLE
Megan M J Bauman, Jeffrey P Graves, Travis J Haller, Ryan A McMillan, David M Routman, Aditya Raghunathan, Janalee K Stokken, Michael J Link, Eric J Moore, Garret Choby, Jamie J Van Gompel
OBJECTIVE: Olfactory neuroblastoma (ONB) is a rare, malignant tumor of the sinonasal tract that arises from olfactory epithelium. Although surgery is the preferred first-line treatment, tumor involvement of adjacent structures may preclude the ability to achieve negative margins during initial resection. Herein, the authors examine the oncological outcomes of patients with positive margins after primary resection of ONB, with the aim of determining predictors of disease progression and patterns of recurrence...
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38463937/ectopic-olfactory-neuroblastoma-systematic-review-of-a-rare-clinical-entity-among-sinonasal-tumors
#4
JOURNAL ARTICLE
Christopher G Lui, Ido Badash, Liyang Tang, Michelle E Mark, Pete S Batra, Bozena B Wrobel
Objectives  Ectopic olfactory neuroblastoma is an uncommon manifestation of an already rare neoplasm. We aimed to systematically review the literature for cases of ectopic olfactory neuroblastoma to better characterize this rare disease entity and to present two new case reports. Methods  A search of the PubMed and Embase databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify English-language articles reporting cases of ectopic olfactory neuroblastoma, published from 1955 through November 2021...
April 2024: Journal of Neurological Surgery. Part B, Skull Base
https://read.qxmd.com/read/38440439/to-study-the-efficacy-of-coblation-in-the-endoscopic-surgery-of-sinonasal-and-skull-base-masses
#5
JOURNAL ARTICLE
Arushi Bhardwaj, Tarun Ojha, Nikhil Soni, Manan Balhara, Nishant Gour
OBJECTIVE: To study the efficacy of coblation in the endoscopic surgery of sinonasal and skull base masses. STUDY DESIGN: Prospective Interventional Study. METHOD: 100 patients with signs and symptoms of nasal obstruction were enrolled for 14 months. On the basis of diagnosis they underwent endoscopic sinus surgery using coblator and their intra-operative blood loss, operation time, post-operative pain threshold using VAS(Visual analogue scale) were enlisted...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38404243/treatment-outcome-of-olfactory-neuroblastoma-a-multicenter-study-by-the-korean-sinonasal-tumor-and-skull-base-surgery-study-group
#6
JOURNAL ARTICLE
Sang Duk Hong, Song I Park, Ji Heui Kim, Sung Jae Heo, Sung-Woo Cho, Tae-Bin Won, Hyun-Jin Cho, Dong Hoon Lee, Sue Jean Mun, Soo Kyoung Park, Yong-Wan Kim, Dong-Young Kim
OBJECTIVES: Due to the rarity of olfactory neuroblastoma (ONB), there is an ongoing debate about optimal treatment strategies, especially for early staged or locally advanced cases. Therefore, our study aims to explore experiences from multiple centers, focusing on factors that influence the oncological outcomes of ONB. METHODS: We retrospectively analyzed 195 ONB patients treated at nine tertiary hospitals in South Korea between December 1992 and December 2019...
February 26, 2024: Clinical and Experimental Otorhinolaryngology
https://read.qxmd.com/read/38386106/update-on-olfactory-neuroblastoma
#7
REVIEW
Fernando Lopez, Abbas Agaimy, Alessandro Franchi, Carlos Suárez, Vincent Vander Poorten, Antti A Mäkitie, Akihiro Homma, Avraham Eisbruch, Kerry D Olsen, Nabil F Saba, Sandra Nuyts, Carl Snyderman, Jonathan J Beitler, June Corry, Ehab Hanna, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
Olfactory neuroblastomas are uncommon malignancies that arise from olfactory receptor cells located high in the nasal cavity. Accurate diagnosis plays a crucial role in determining clinical results and guiding treatment decisions. Diagnosis can be a major challenge for pathologists, especially when dealing with tumours with poor differentiation. The discovery of several molecular and immunohistochemical markers would help to overcome classification difficulties. Due to the paucity of large-scale studies, standardisation of diagnosis, treatment and prediction of outcome remains a challenge...
February 22, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38372441/snot-22-subdomain-outcomes-following-treatment-for-sinonasal-malignancy-a-prospective-multicenter-study
#8
JOURNAL ARTICLE
David R Grimm, Daniel M Beswick, Sabrina L Maoz, Eric W Wang, Garret W Choby, Edward C Kuan, Erik P Chan, Nithin D Adappa, Mathew Geltzeiler, Anne E Getz, Ian M Humphreys, Christopher H Le, Waleed M Abuzeid, Eugene H Chang, Aria Jafari, Todd T Kingdom, Michael A Kohanski, Jivianne K Lee, Jayakar V Nayak, James N Palmer, Zara M Patel, Carlos D Pinheiro-Neto, Adam C Resnick, Myung S Sim, Timothy L Smith, Carl H Snyderman, Maie A John, Phillip Storm, Jeffrey D Suh, Marilene B Wang, Peter H Hwang
BACKGROUND: Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22-item Sinonasal Outcomes Test (SNOT-22) has been shown to improve with treatment. This study aims to characterize SNOT-22 subdomain outcomes in SNM. METHODS: Patients diagnosed with SNM were prospectively enrolled in a multi-center patient registry. SNOT-22 scores were collected at the time of diagnosis and through the post-treatment period for up to 5 years...
February 19, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38352894/upright-proton-therapy-for-esthesioneuroblastoma-a-single-institution-experience
#9
JOURNAL ARTICLE
Konstantin Gordon, Igor Gulidov, Daniil Smyk, Alexey Semenov, Kirill Golubev, Alyona Lemaeva, Sergey Koryakin, Enar Jumaniyazova, Polina Vishnyakova, Irina Eremina, Timur Fatkhudinov, Andrey Kaprin
AIM: This study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position. BACKGROUND: Esthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximity to vital structures. Proton therapy (PT) is often considered the optimal radiation treatment for head-and-neck tumors, although of limited availability. Upright PT delivered using fixed pencil beamline and rotating chair is a fairly promising option...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38246527/characterizing-immune-infiltration-in-esthesioneuroblastoma-subtypes-through-gene-expression-deconvolution
#10
JOURNAL ARTICLE
Sai Batchu, Amarbir S Gill, Michael Karsy
BACKGROUND: Esthesioneuroblastoma (ENB) is a rare cancer deriving from the olfactory mucosa. Among the basal or neural genomic subtypes, the basal subtype is associated with poorer survival, poor differentiation, and higher levels of tumor-infiltrating immune cells (TIICs). The immune microenvironment of these ENB subtypes remains unclear. We used an established machine learning algorithm on ENB transcriptomic profiles. METHODS: The authors characterized 22 immune cell populations using the CIBERSORTx deconvolutional machine learning pipeline on RNA sequencing data from 18 ENB cases...
January 19, 2024: World Neurosurgery
https://read.qxmd.com/read/38134571/the-medial-transorbital-approach-in-cranioendoscopic-skull-base-tumor-resections-for-locally-advanced-tumors
#11
JOURNAL ARTICLE
Daniel W Scholfield, Helena Levyn, Viviane S Tabar, Ian Ganly, David Della Rocca, Marc A Cohen
BACKGROUND: Orbital structure preservation and avoidance of facial incisions without compromising oncological outcome are key to maintaining function and quality of life in locally advanced sinonasal tumor surgery. A transorbital approach at our institution has proven invaluable during cranioendoscopic skull base tumor resections and there are few descriptions of this in the literature. METHODS: An IRB-approved retrospective chart review was conducted at a tertiary cancer center for patients between 2020 and 2022 undergoing cranioendoscopic tumor resections utilizing a transorbital approach...
January 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38116847/oncology-for-the-rhinologist
#12
REVIEW
Kenric Tam, Lara A Dunn, Marc A Cohen
PURPOSE OF REVIEW: The purpose of this review is to summarize current evidence regarding the use of induction chemotherapy for a variety of histopathologies of sinonasal malignancy (SNMs) and to review the potential adverse effects of cytotoxic agents. RECENT FINDINGS: Historically, patients with locally advanced SNMs have had relatively poor prognoses and high morbidity from treatment. The available retrospective data suggests that induction chemotherapy may improve outcomes for patients with sinonasal undifferentiated carcinoma (SNUC), neuroendocrine carcinoma, squamous cell carcinoma (SSCC), and esthesioneuroblastoma...
February 1, 2024: Current Opinion in Otolaryngology & Head and Neck Surgery
https://read.qxmd.com/read/38098697/rare-case-of-mortality-after-hemorrhagic-property-of-esthesioneuroblastoma
#13
Todd Furr, Brandon Grodman, Jeremy Heffernan
Esthesioneuroblastoma is a tumor arising from olfactory neuroepithelium with an incidence of four per million. This case presents a rare nasal cavity neoplasm with hemorrhagic properties that may lead to significant sequelae. We present a 69-year-old male patient who presented with worsening altered mental status over the past 6-7 months. His Glasgow coma scale was a nine, showing a large mass centered at the cribriform plate with extension intracranially, sinonasal cavity, and bilateral orbits on diagnostics...
2023: Archive of clinical cases
https://read.qxmd.com/read/38085897/skull-base-tumors
#14
REVIEW
Deborah A Forst, Pamela S Jones
OBJECTIVE: This article reviews the presenting features, molecular characteristics, diagnosis, and management of selected skull base tumors, including meningiomas, vestibular schwannomas, pituitary neuroendocrine tumors, craniopharyngiomas, chordomas, ecchordosis physaliphora, chondrosarcomas, esthesioneuroblastomas, and paragangliomas. LATEST DEVELOPMENTS: Skull base tumors pose a management challenge given their complex location and, as a result, the tumors and treatment can result in significant morbidity...
December 1, 2023: Continuum: Lifelong Learning in Neurology
https://read.qxmd.com/read/38048560/genomic-characterization-of-an-esthesioneuroblastoma-with-spinal-metastases-illustrative-case
#15
JOURNAL ARTICLE
Bianca M Marin, Nathan K Leclair, Erica Shen, Avery Buehler, Upendra P Hegde, Qian Wu, Kevin Becker, Lei Li, Seth Brown, Leo J Wolansky, Hilary Onyiuke, David Choi, Ketan R Bulsara
BACKGROUND: Esthesioneuroblastoma (ENB) is a rare neoplasm of the sinonasal tract. Currently, the optimal treatment includes maximal resection combined with radiotherapy and/or chemotherapy. Although ENBs often recur and have an aggressive clinical course, spinal metastases are extremely rare and the underlying molecular mechanisms are poorly understood. OBSERVATIONS: Here, the authors describe a 50-year-old male with an aggressive ENB, initially treated with resection and chemotherapy/radiation, who developed multiple thoracic and lumbar spinal metastases...
December 4, 2023: J Neurosurg Case Lessons
https://read.qxmd.com/read/38041523/simple-and-safe-resection-of-the-crista-galli
#16
JOURNAL ARTICLE
Kazuhiro Omura, Kazuhiro Nomura, Satoshi Aoki, Teppei Takeda, Teru Ebihara, Adam J Kimple, Brian D Thorp, Abdullah L Zeatoun, Nobuyoshi Otori, Brent A Senior
A critical procedure in the transcribriform approach is the resection of the crista galli. However, the standard technique for crista galli resection has several disadvantages. We reviewed the cases of patients with olfactory neuroblastomas who underwent an endoscopic endonasal transcribriform approach using a newly developed technique for crista galli resection. We performed a cadaveric study to measure the superior accessibility limits using the proposed method. We included 38 patients with olfactory neuroblastomas in this study...
December 2, 2023: Head & Neck
https://read.qxmd.com/read/38018357/outcomes-following-proton-therapy-for-pediatric-esthesioneuroblastoma
#17
JOURNAL ARTICLE
Nicolette R Drescher, Daniel J Indelicato, Roi Dagan, Julie A Bradley, Adam L Holtzman, Raymond B Mailhot Vega, Philipp R Aldana, Eric S Sandler, Christopher G Morris, William M Mendenhall
BACKGROUND: Pediatric esthesioneuroblastoma (EN) can infiltrate skull base anatomy, presenting challenges due to high radiation doses and pediatric tissue sensitivity. This study reports outcomes of pediatric EN treated with proton radiotherapy (PT). PROCEDURE: Using an IRB-approved prospective outcomes registry, we evaluated patient, tumor, and treatment-related variables impacting disease control and toxicity in pediatric nonmetastatic EN treated with modern multimodality therapy, including PT...
February 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/37927675/failure-patterns-of-recurrence-in-patients-with-localized-esthesioneuroblastoma-following-surgery-and-adjuvant-radiotherapy-without-elective-nodal-irradiation
#18
JOURNAL ARTICLE
Atsuto Katano, Masanari Minamitani, Shingo Ohira, Hideomi Yamashita
BACKGROUND: Esthesioneuroblastoma (ENB), a rare malignancy arising from the olfactory epithelium, poses clinical challenges owing to its propensity for local invasion and recurrence. Its management typically involves surgical resection and adjuvant radiotherapy. However, debate persists regarding the optimal treatment strategy, particularly the use of elective nodal irradiation (ENI). This study aimed to investigate recurrence patterns in patients with localized ENB treated with surgery and adjuvant radiotherapy without ENI...
October 2023: Curēus
https://read.qxmd.com/read/37909011/olfactory-neuroblastoma-diagnosis-management-and-current-treatment-options
#19
REVIEW
Alicia Tosoni, Vincenzo Di Nunno, Lidia Gatto, Giacomo Corradi, Stefania Bartolini, Lucia Ranieri, Enrico Franceschi
Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37908997/primary-sellar-neuroblastoma-masquerading-as-a-pituitary-macroadenoma
#20
Nandini Seshan, Simon Hanft, Gayotri Goswami, Arjun Syal
Olfactory neuroblastomas, or esthesioneuroblastomas, are rare and aggressive malignant tumors that typically arise from the olfactory neuroepithelium in the upper nasal cavity. In rare instances, they can be ectopic originating from areas outside the upper nasal cavity such as the sellar region. These tumors, also known as primary sellar neuroblastomas, may be mistaken for pituitary macroadenomas. We present a rare case of a primary sellar neuroblastoma in a 30-year-old woman with a prior diagnosis of presumed prolactinoma, status post transsphenoidal resection, with residual visual deficits, who presented with worsening vision and headaches...
July 2023: JCEM Case Rep
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