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esthesioneuroblastoma

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https://www.readbyqxmd.com/read/28815831/prognostic-significance-of-kadish-staging-in-esthesioneuroblastoma-an-analysis-of-the-national-cancer-database
#1
Neeraja Konuthula, Alfred M Iloreta, Brett Miles, Ryan Rhome, Umut Ozbek, Eric M Genden, Marshall Posner, Krzysztof Misiukiewicz, Satish Govindaraj, Raj Shrivastava, Vishal Gupta, Richard L Bakst
BACKGROUND: Given the rarity of esthesioneuroblastoma, it is difficult to validate a staging system. The purpose of this study was to investigate the utility of the Kadish staging system in esthesioneuroblastoma using the National Cancer Database (NCDB). METHODS: One thousand one hundred sixty-seven patients with esthesioneuroblastoma were identified from the NCDB. RESULTS: Five-year survival was 80.0% for Kadish A, 87.7% for Kadish B, 77...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#2
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan R Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR) based DNA next generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n=16), mxPCR based RNA NGS of 108 target genes (n=15), and two ONBs profiled by comprehensive hybrid-capture based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28620574/complications-of-advanced-kadish-stage-esthesioneuroblastoma-single-institution-experience-and-literature-review
#3
Sheri K Palejwala, Saurabh Sharma, Christopher H Le, Eugene Chang, Michael Lemole
INTRODUCTION: In esthesioneuroblastoma, greater disease extent and Kadish staging correlate with greater recurrence, complications, and mortality. These advanced stage malignancies require extensive resections and aggressive adjuvant therapy. This increases the risk of complications such as cerebrospinal fluid leak, neurologic deficits, and osteomyelitis. We present our case series and then analyze the literature to ascertain whether advanced stage tumors corresponds to greater rates of complications...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28607817/a-rare-case-report-of-mixed-olfactory-neuroblastoma-carcinoma-with-review-of-literature
#4
Charandeep S Gandhoke, Aditi Dewan, Divya Gupta, Simran K Syal, Anita Jagetia, Ravindra K Saran, Ravi Meher, Arvind K Srivastava, Daljit Singh
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor of the nasal cavity. Mixed olfactory neuroblastoma which contains areas of divergent differentiation is even rare. Till date, only 4 cases of mixed olfactory neuroblastomas have been reported. CASE DESCRIPTION: We report the case of a 46-year-old male who presented with the chief complaints of nasal bleeding and nasal obstruction since 4 months. Radiological imaging was suggestive of a large heterogeneous mass in the left superior nasal cavity with extensions into bilateral maxillary, ethmoidal, and sphenoidal sinuses, as well as into the anterior cranial fossa...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28595773/endoscopic-endonasal-management-of-esthesioneuroblastoma-a-retrospective-multicenter-study
#5
Takayuki Nakagawa, Satoru Kodama, Masayoshi Kobayashi, Tetsuji Sanuki, Shuho Tanaka, Nobuhiro Hanai, Toyoyuki Hanazawa, Hiroko Monobe, Hidenori Yokoi, Motohiko Suzuki, Masaru Yamashita, Koichi Omori
OBJECTIVE: The aim of the present study was to illustrate the safety and utility of the endoscopic endonasal approach (EEA) for the treatment of esthesioneuroblastomas (ENB). METHODS: We retrospectively reviewed patients with a diagnosis of ENB between March 2008 and February 2016 at 10 tertiary referral hospitals in Japan, and assessed demographic data, stage of disease, surgical approach, outcomes and postoperative complications. RESULTS: A total of 22 patients (10 males and 12 females; mean age at presentation, 49...
June 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28495808/comprehensive-genomic-profiling-of-esthesioneuroblastoma-reveals-additional-treatment-options
#6
Laurie M Gay, Sungeun Kim, Kyle Fedorchak, Madappa Kundranda, Yazmin Odia, Chaitali Nangia, James Battiste, Gerardo Colon-Otero, Steven Powell, Jeffery Russell, Julia A Elvin, Jo-Anne Vergilio, James Suh, Siraj M Ali, Philip J Stephens, Vincent A Miller, Jeffrey S Ross
BACKGROUND: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant neoplasm of the olfactory mucosa. Despite surgical resection combined with radiotherapy and adjuvant chemotherapy, ENB often relapses with rapid progression. Current multimodality, nontargeted therapy for relapsed ENB is of limited clinical benefit. MATERIALS AND METHODS: We queried whether comprehensive genomic profiling (CGP) of relapsed or refractory ENB can uncover genomic alterations (GA) that could identify potential targeted therapies for these patients...
July 2017: Oncologist
https://www.readbyqxmd.com/read/28483228/clinical-manifestations-of-neuroblastoma-with-head-and-neck-involvement-in-children
#7
Sameer Alvi, Omar Karadaghy, Michelle Manalang, Robert Weatherly
OBJECTIVE: The purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms. STUDY DESIGN: Retrospective chart review of electronic medical record. SETTING: An academic, tertiary care pediatric hospital. SUBJECTS AND METHODS: IRB approval from the Office of Research Integrity at Children's Mercy Hospital was obtained...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28480156/complex-skull-base-reconstructions-in-kadish-d-esthesioneuroblastoma-case-report
#8
Sheri K Palejwala, Saurabh Sharma, Christopher H Le, Eugene Chang, Audrey B Erman, G Michael Lemole
Introduction Advanced Kadish stage esthesioneuroblastoma requires more extensive resections and aggressive adjuvant therapy to obtain adequate disease-free control, which can lead to higher complication rates. We describe the case of a patient with Kadish D esthesioneuroblastoma who underwent multiple surgeries for infectious, neurologic, and wound complications, highlighting potential preventative and salvage techniques. Case Presentation A 61-year-old man who presented with a large left-sided esthesioneuroblastoma, extending into the orbit, frontal lobe, and parapharyngeal nodes...
April 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28399835/optimal-treatment-and-prognostic-factors-for-esthesioneuroblastoma-retrospective-analysis-of-187-chinese-patients
#9
Le Xiong, Xiao-Li Zeng, Chang-Kuo Guo, An-Wen Liu, Long Huang
BACKGROUND: The standard treatment for esthesioneuroblastoma, a rare malignant nasal vault neoplasm, is not established. METHODS: We retrospectively assessed the clinicopathological features, prognostic factors and treatment methods for 187 patients with esthesioneuroblastoma treated in China between 1981 and 2015. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method and log-rank tests. RESULTS: Twenty-three (12...
April 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28362545/remote-orbital-recurrence-of-olfactory-neuroblastoma-esthesioneuroblastoma
#10
Mark P Breazzano, James S Lewis, Lola B Chambless, Sarah L Rohde, Rachel K Sobel
Olfactory neuroblastoma is a rare and often locally aggressive malignancy that invades the orbit via local destruction. It is known to recur in a delayed fashion, particularly to the neck lymph nodes. This is a case of a 65-year-old gentleman who presents with recurrence in the orbit and a neck lymph node 19 years after treatment for his initial disease. This report describes the longest known interval in orbital recurrence and should alert the monitoring physician that extreme delays in recurrence can occur...
August 2017: Orbit
https://www.readbyqxmd.com/read/28239593/ectopic-esthesioneuroblastoma-of-the-sphenoclivus-a-rare-entity
#11
Farah Dayana Zahedi, Balwant Singh Gendeh, Salina Husain, Ramesh Kumar, Thean Yean Kew
Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management, We report a rare case of ectopic esthesioneuroblastoma of the sphenoclivus with the presentation of intermittent unilateral epistaxis, intermittent intractable headache without anosmia. Nasal endoscopy findings showed a pulsatile mass at the anterior face of the sphenoid sinus with extension posteriorly towards the clivus region and occupying the floor of the sphenoid sinus...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28180046/risk-of-delayed-lymph-node-metastasis-in-clinically-n0-esthesioneuroblastoma
#12
Justin G Peacock, William S Harmsen, Michael J Link, Jamie J Van Gompel, Caterina Giannini, Kerry D Olsen, Yolanda I Garces, Michelle A Neben Wittich, Daniel J Ma, Sean S Park, Robert L Foote
Objective To determine both the rate of delayed cervical lymph node metastasis in patients with esthesioneuroblastoma (ENB) and a clinically N0 untreated neck and the effectiveness of salvage treatment. Design Retrospective review. Setting Tertiary academic medical center. Participants All patients from January 1, 1965, to December 31, 2010, who received definitive treatment for ENB. Main Outcome Measures The study involved 52 patients: 27 (52%) patients underwent surgery and adjuvant radiotherapy (SART) to the primary site only and 25 (48%) underwent surgery alone (SA) as treatment of the primary site, without elective neck dissection...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28060373/small-round-blue-cell-tumors-of-the-sinonasal-tract-a-differential-diagnosis-approach
#13
Lester Dr Thompson
One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#14
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
March 2017: Head & Neck
https://www.readbyqxmd.com/read/28018456/esthesioneuroblastoma-in-a-boy-with-47-xyy-karyotype
#15
Hee Cheol Jo, Seong Wook Lee, Hyun Joo Jung, Jun Eun Park
Neuroblastomas are sometimes associated with abnormal constitutional karyotypes, but the XYY karyotype has been rarely described in neuroblastomas. Here, we report a case of an esthesioneuroblastoma in a boy with a 47, XYY karyotype. A 6-year-old boy was admitted to our hospital because of nasal obstruction and palpable cervical lymph node, which he first noticed several days previously. A polypoid mass in the right nasal cavity was detected through sinuscopy. Biopsy of the right nasal polyp was performed. Based on the result, the patient was diagnosed with a high-grade esthesioneuroblastoma...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27938977/staged-endonasal-external-resection-of-esthesioneuroblastoma-involving-the-nasolacrimal-duct-and-lacrimal-sac
#16
Michel J Belliveau, James C M Wang, Navdeep Nijhawan, Eleanor K Latta, John M Lee
No abstract text is available yet for this article.
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27882120/lutetium-177-dota-tate-therapy-for-esthesioneuroblastoma-a-case-report
#17
Juliano Guerra Sabongi, Mônica Carboni Pereira Gonçalves, Cira Danielle Casado Alves, João Alves, Cristovam Scapulatempo-Neto, Sonia Marta Moriguchi
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27715372/aggressive-esthesioneuroblastoma-with-divergent-differentiation-a-taxonomic-dilemma
#18
Norman C Charles, Carisa K Petris, Eleanore T Kim
The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histopathology showed a high-grade neuroepithelial tumor with positive immunohistochemical markers for neuroendocrine and epithelial components, an unusual combination raising issues concerning taxonomy.
December 2016: Orbit
https://www.readbyqxmd.com/read/27674510/definitive-radiation-in-the-treatment-of-locally-advanced-esthesioneuroblastoma-an-analysis-of-the-national-cancer-data-base
#19
N Konuthula, A M Iloreta, R M Rhome, M Posner, K Misiukiewicz, V Gupta, R L Bakst
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27630897/esthesioneuroblastomas-reservations-and-recommendations
#20
Rajesh Nair, Bhavna Nayal, Vinod Kumar, Padmapriya Jaiprakash
Neuroectodermal tumour has a wide range of biological activity that ranges from an indolent course to local recurrence and rapid widespread metastasis. We describe, herewith, 2 patients with Esthesioneuroblastomas (ENB) who had varied atypical clinical presentation. The first case presented with Intracranial Pressure (ICP) headache and acute visual deterioration with radiology revealing an extra axial lesion with extension into the nasal cavity while the second case presented with nasal congestion and progressive headache of long duration...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
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