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esthesioneuroblastoma

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https://www.readbyqxmd.com/read/29456962/neuroectodermally-derived-neoplasm-of-tonsil-difficulty-in-histomorphological-diagnosis
#1
Albina Venus, Sangita Sharma Mehta
Esthesioneuroblastomas are rare neuroectodermally derived neoplasms occurring in the upper nasal septum or cribriform plate. They have been rarely reported in other sites, when they are called ectopic esthesioneuroblastomas. Due to the scarcity of reports, publications and molecular/genetic studies of these tumours, their diagnosis is likely to be missed when they are ectopic. Similar to the case report in this journal by Zahedi et al., we had a case of neuroectodermally derived neoplasm of the tonsil, which was difficult to diagnose, due to the site of occurrence being unknown for these tumours...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29444558/limitations-of-the-endoscopic-endonasal-transcribriform-approach
#2
Neil Majmundar, Naveed Kamal, Renuka Reddy, Jean A Eloy, James K Liu
The endoscopic endonasal transcribriform approach (EETA) has become a useful strategy in the treatment of various anterior skull base pathology, including meningoencephaloceles, olfactory groove meningiomas, schwannomas, esthesioneuroblastomas, and other sinonasal malignancies. However, not all pathologies are optimally treated through this approach due to tumor size, extent of the lesion, vascular involvement, and the presence of intact olfaction. One must be prepared to use a transcranial approach if the EETA is not favorable...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29427378/dural-recurrence-among-esthesioneuroblastoma-patients-presenting-with-intracranial-extension
#3
Yao Yu, Ivan H El-Sayed, Michael W McDermott, Philip V Theodosopoulos, Annemieke van Zante, Norbert Kased, Christine M Glastonbury, Adam A Garsa, Sue S Yom
OBJECTIVE: To quantify the rate of late intracranial recurrences among esthesioneuroblastoma patients treated with surgical resection and postoperative radiation. STUDY DESIGN: Retrospective review. METHODS: All patients receiving definitive-intent therapy for esthesioneuroblastoma between March 1995 and September 2015 were reviewed. Presenting disease extent was categorized based on radiologic, operative, and pathologic findings. Between-group survival differences were assessed using Kaplan-Meier method and log-rank test...
February 10, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29342907/an-uncommon-case-of-pediatric-esthesioneuroblastoma-presenting-as-siadh-18f-fdg-pet-ct-in-staging-and-post-therapeutic-assessment
#4
Marie Øbro Fosbøl, Anders Bilde, Jeppe Friborg, Eric von Benzon, Andreas Kjær, Christian von Buchwald, Lise Borgwardt
Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients...
January 14, 2018: Diagnostics
https://www.readbyqxmd.com/read/29341337/endoscopic-endonasal-approach-for-sinonasal-and-anterior-skull-base-malignancies-in-the-elderly
#5
Davide Lepera, Federico Leone, Luca Volpi, Maurizio Bignami, Apostolos Karligkiotis, Alessia Lambertoni, Andrea Pistochini, Remo Accorona, Piero Nicolai, Paolo Castelnuovo
BACKGROUND: The purpose of this study was to report the outcomes of endoscopic transnasal resection for sinonasal and anterior skull-base cancers in elderly patients. METHODS: A retrospective review was performed. The patients were divided into 2 groups, <70 years old and ≥70 years old and compared by univariate analysis. Prognostic factors were evaluated with a multivariate analysis. Survival rates were also calculated. RESULTS: Two hundred three elderly patients and 397 younger patients were enrolled in this study...
January 17, 2018: Head & Neck
https://www.readbyqxmd.com/read/29290783/exploration-of-the-optimal-treatment-regimes-for-esthesioneuroblastoma-a-single-center-experience-in-china
#6
Yujie Yuan, Jinning Ye, Huizhi Qiu, Shaoqing Niu, Bixiu Wen, Dongping Wang, Xinping Cao, Yufeng Ren
BACKGROUND: Esthesioneuroblastoma (ENB) is an uncommon neoplasm arising from the olfactory mucosa. The optimal treatment regimen for ENB remains unclear. This study aims to evaluate its clinical features, long-term outcomes and explore optimal treatment patterns. METHODS: Clinical data of consecutive 44 ENB patients were reviewed retrospectively. The correlation between clinical features and treatment approaches were analyzed, with several prognostic factors explored meanwhile. RESULTS: The age of onset of ENB showed a bimodal distribution, with peaks at 10~20 and 50~60 years...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29277853/endoscopic-endonasal-resection-of-sinonasal-anterior-skull-base-malignancy-kadish-c-esthesioneuroblastoma
#7
Gautam U Mehta, Ehab Y Hanna, Franco DeMonte, Shaan M Raza
BACKGROUND: The surgical management of anterior skull base malignancies requires the full complement of open and endoscopic skull base approaches. Due to the evolution of endoscopic techniques, endoscopic approaches are now being employed for complex skull base tumors. METHODS: We present our technique for endoscopic management for an advanced (T4) anterior skull base malignancy that provides a systematic approach to resection, margin assessment, and reconstruction...
December 26, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29217745/intranasal-esthesioneuroblastoma-ct-patterns-aid-in-preventing-routine-nasal-polypectomy
#8
M E Peckham, R H Wiggins, R R Orlandi, Y Anzai, W Finke, H R Harnsberger
BACKGROUND AND PURPOSE: Esthesioneuroblastoma is a neuroectodermal tumor that commonly arises in the nasal cavity olfactory recess and, when isolated to the intranasal cavity, can be indistinguishable from benign processes. Because lesional aggressiveness requires a more invasive operation for resection than polypectomy, patients with isolated intranasal lesions were studied to define distinguishing CT characteristics. MATERIALS AND METHODS: Patients with intranasal esthesioneuroblastoma and controls without esthesioneuroblastoma with olfactory recess involvement were identified by using a report search tool...
February 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29045018/patient-disease-and-treatment-factors-associated-with-overall-survival-in-esthesioneuroblastoma
#9
Ryan M Carey, Joseph Godovchik, Alan D Workman, Edward C Kuan, Arjun K Parasher, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant
BACKGROUND: Esthesioneuroblastomas (ENB) are uncommon and data regarding outcomes are often limited to single-institution series. The National Cancer Database (NCDB), which contains outcomes information from treatment centers across the United States, represents an opportunity to evaluate outcomes for rare diseases such as ENB across multiple institutions. METHODS: The NCDB was queried for location codes corresponding to the nasal cavity and paranasal sinuses and the histology code for ENB...
October 17, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28969258/esthesioneuroblastoma-presenting-with-bilateral-proptosis-and-blindness-in-a-child-a-case-report
#10
Mahdi Shahriari, Nader Shakibazad, Mehrpour Moradi
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-month-old girl with esthesioneuroblastoma in sphenoid and ethmoid sinus in a child presenting with bilateral proptosis, blindness, and irritability. The diagnosis was confirmed by histopathology.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28882714/combined-minimally-invasive-supraciliary-and-transfacial-approach-for-large-tumors-with-skull-base-and-sinonasal-involvement
#11
Pal Barzo, Zsolt Zador, Mihaly Bodosi, Zsolt Bella, Daniel Jambor, Bela Fulop, Jeno Czigner
BACKGROUND: Tumors invading both the anterior skull base and the sinonasal area have been traditionally accessed via largely invasive open craniofacial approaches. Minimally invasive extended endoscopic endonasal approaches have recently become increasingly available, but have anatomical limitations and require incremental experience and thus high patient volume. Our objective was to assess the applicability of a novel combination of the minimally invasive supraciliary incision and the limited maxillofacial osteotomy as a combined surgical approach for large tumors invading both the anterior skull base and the sinonasal area...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28815831/prognostic-significance-of-kadish-staging-in-esthesioneuroblastoma-an-analysis-of-the-national-cancer-database
#12
Neeraja Konuthula, Alfred M Iloreta, Brett Miles, Ryan Rhome, Umut Ozbek, Eric M Genden, Marshall Posner, Krzysztof Misiukiewicz, Satish Govindaraj, Raj Shrivastava, Vishal Gupta, Richard L Bakst
BACKGROUND: Given the rarity of esthesioneuroblastoma, it is difficult to validate a staging system. The purpose of this study was to investigate the utility of the Kadish staging system in esthesioneuroblastoma using the National Cancer Database (NCDB). METHODS: One thousand one hundred sixty-seven patients with esthesioneuroblastoma were identified from the NCDB. RESULTS: Five-year survival was 80.0% for Kadish A, 87.7% for Kadish B, 77...
October 2017: Head & Neck
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#13
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR)-based DNA next-generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n = 16), mxPCR-based RNA NGS of 108 target genes (n = 15), and 2 ONBs profiled by comprehensive hybrid-capture-based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28620574/complications-of-advanced-kadish-stage-esthesioneuroblastoma-single-institution-experience-and-literature-review
#14
Sheri K Palejwala, Saurabh Sharma, Christopher H Le, Eugene Chang, Michael Lemole
INTRODUCTION: In esthesioneuroblastoma, greater disease extent and Kadish staging correlate with greater recurrence, complications, and mortality. These advanced stage malignancies require extensive resections and aggressive adjuvant therapy. This increases the risk of complications such as cerebrospinal fluid leak, neurologic deficits, and osteomyelitis. We present our case series and then analyze the literature to ascertain whether advanced stage tumors corresponds to greater rates of complications...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28607817/a-rare-case-report-of-mixed-olfactory-neuroblastoma-carcinoma-with-review-of-literature
#15
Charandeep S Gandhoke, Aditi Dewan, Divya Gupta, Simran K Syal, Anita Jagetia, Ravindra K Saran, Ravi Meher, Arvind K Srivastava, Daljit Singh
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor of the nasal cavity. Mixed olfactory neuroblastoma which contains areas of divergent differentiation is even rare. Till date, only 4 cases of mixed olfactory neuroblastomas have been reported. CASE DESCRIPTION: We report the case of a 46-year-old male who presented with the chief complaints of nasal bleeding and nasal obstruction since 4 months. Radiological imaging was suggestive of a large heterogeneous mass in the left superior nasal cavity with extensions into bilateral maxillary, ethmoidal, and sphenoidal sinuses, as well as into the anterior cranial fossa...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28595773/endoscopic-endonasal-management-of-esthesioneuroblastoma-a-retrospective-multicenter-study
#16
Takayuki Nakagawa, Satoru Kodama, Masayoshi Kobayashi, Tetsuji Sanuki, Shuho Tanaka, Nobuhiro Hanai, Toyoyuki Hanazawa, Hiroko Monobe, Hidenori Yokoi, Motohiko Suzuki, Masaru Yamashita, Koichi Omori
OBJECTIVE: The aim of the present study was to illustrate the safety and utility of the endoscopic endonasal approach (EEA) for the treatment of esthesioneuroblastomas (ENB). METHODS: We retrospectively reviewed patients with a diagnosis of ENB between March 2008 and February 2016 at 10 tertiary referral hospitals in Japan, and assessed demographic data, stage of disease, surgical approach, outcomes and postoperative complications. RESULTS: A total of 22 patients (10 males and 12 females; mean age at presentation, 49...
June 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28495808/comprehensive-genomic-profiling-of-esthesioneuroblastoma-reveals-additional-treatment-options
#17
Laurie M Gay, Sungeun Kim, Kyle Fedorchak, Madappa Kundranda, Yazmin Odia, Chaitali Nangia, James Battiste, Gerardo Colon-Otero, Steven Powell, Jeffery Russell, Julia A Elvin, Jo-Anne Vergilio, James Suh, Siraj M Ali, Philip J Stephens, Vincent A Miller, Jeffrey S Ross
BACKGROUND: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant neoplasm of the olfactory mucosa. Despite surgical resection combined with radiotherapy and adjuvant chemotherapy, ENB often relapses with rapid progression. Current multimodality, nontargeted therapy for relapsed ENB is of limited clinical benefit. MATERIALS AND METHODS: We queried whether comprehensive genomic profiling (CGP) of relapsed or refractory ENB can uncover genomic alterations (GA) that could identify potential targeted therapies for these patients...
July 2017: Oncologist
https://www.readbyqxmd.com/read/28483228/clinical-manifestations-of-neuroblastoma-with-head-and-neck-involvement-in-children
#18
Sameer Alvi, Omar Karadaghy, Michelle Manalang, Robert Weatherly
OBJECTIVE: The purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms. STUDY DESIGN: Retrospective chart review of electronic medical record. SETTING: An academic, tertiary care pediatric hospital. SUBJECTS AND METHODS: IRB approval from the Office of Research Integrity at Children's Mercy Hospital was obtained...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28480156/complex-skull-base-reconstructions-in-kadish-d-esthesioneuroblastoma-case-report
#19
Sheri K Palejwala, Saurabh Sharma, Christopher H Le, Eugene Chang, Audrey B Erman, G Michael Lemole
Introduction Advanced Kadish stage esthesioneuroblastoma requires more extensive resections and aggressive adjuvant therapy to obtain adequate disease-free control, which can lead to higher complication rates. We describe the case of a patient with Kadish D esthesioneuroblastoma who underwent multiple surgeries for infectious, neurologic, and wound complications, highlighting potential preventative and salvage techniques. Case Presentation A 61-year-old man who presented with a large left-sided esthesioneuroblastoma, extending into the orbit, frontal lobe, and parapharyngeal nodes...
April 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28399835/optimal-treatment-and-prognostic-factors-for-esthesioneuroblastoma-retrospective-analysis-of-187-chinese-patients
#20
Le Xiong, Xiao-Li Zeng, Chang-Kuo Guo, An-Wen Liu, Long Huang
BACKGROUND: The standard treatment for esthesioneuroblastoma, a rare malignant nasal vault neoplasm, is not established. METHODS: We retrospectively assessed the clinicopathological features, prognostic factors and treatment methods for 187 patients with esthesioneuroblastoma treated in China between 1981 and 2015. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method and log-rank tests. RESULTS: Twenty-three (12...
April 11, 2017: BMC Cancer
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