keyword
MENU ▼
Read by QxMD icon Read
search

metastatic testicular cancer

keyword
https://www.readbyqxmd.com/read/29736376/a-rare-case-of-isolated-castrate-resistant-bilateral-testicular-metastases-in-advanced-prostate-cancer
#1
Jiarui Su, Edwin Jonathan Aslim, Hakan Aydin, Puay Hoon Tan, Henry Sun Sien Ho
Testicular metastasis is rare with the prostate being the most common site of primary cancer. We report a case of a 72-year-old man with castration-resistant prostate cancer (CRPC) and known metastases to bone and lymph nodes, who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate cancer. He had first presented with lower urinary tract symptoms (LUTS) with suspicious findings on digital rectal examination of the prostate, and an elevated serum prostate specific antigen (PSA) level of 129 ng/mL...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29703969/role-of-one-two-and-three-doses-of-high-dose-chemotherapy-with-autologous-transplantation-in-the-treatment-of-high-risk-or-relapsed-testicular-cancer-a-systematic-review
#2
Irbaz Bin Riaz, Muhammad Umar, Umar Zahid, Muhammad Husnain, Ahmad Iftikhar, Ali McBride, Jawad Bilal, Asad Javed, Sara Akbar, Parminder Singh, Zeeshan Ali, Qurat Ul Ain Riaz Sipra, Farva Razia Gondal, Frederick Ahman, Faiz Anwer
Approximately 20-30% of patients with metastatic germ cell cancers (GCCs) can develop relapsed or refractory (RR) disease, about 40-50% of patients who relapse after salvage chemotherapy may reach long-term remission. The goal of this review was to identify patients who appear to benefit from high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT). To access this, we performed a systematic medical literature review to evaluate the effectiveness of HDCT in the frontline setting, as well as in patients with RR testicular cancer...
April 27, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29615170/disease-characteristics-and-treatment-outcome-of-testicular-germ-cell-tumors-treated-with-platinum-based-regimens
#3
Amir Sattar, Misbah Masood, Hasan Nisar, Ismat Fatima, Abu Baker Shahid
OBJECTIVE: To determine the disease characteristics of testicular germ cell tumor, biochemical/radiological response to chemotherapy and common toxicity profile. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2010 to December 2013. METHODOLOGY: Fifty-one patients with histologically proven testicular germ cell tumor, who fulfilled the pre-defined eligibility criteria, were selected...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29593471/rare-metastatic-testicular-cancer-in-a-veteran
#4
Umar Karaman, Faye B Serkin, Jennifer M Taylor, Michael Constantinescu
Testicular yolk sac tumor (YST) is a nonseminomatous germ cell tumor that predominantly affects prepubescent boys. Pure endometrioid variant YST is rare, with only 1 report in the literature. We present the first reported case of en-dometrioid variant YST with mature teratoma in the retro-peritoneal specimen.
February 2018: Current Urology
https://www.readbyqxmd.com/read/29557197/dose-intense-chemotherapy-in-the-management-of-poor-prognosis-and-relapsed-testicular-cancer-experiences-and-controversies
#5
Kenrick Ng, Sarah Duncan, Jonathan Shamash, Constantine Alifrangis
The treatment of poor prognosis chemotherapy naïve or relapsed testicular cancer is challenging. In poor prognosis treatment naïve disease, the outlook for patients with standard approaches utilising three weekly cisplatin based regimens, most commonly bleomycin, etoposide and cisplatin (BEP) is suboptimal, and one can expect more than half of patients to relapse or progress and need salvage treatment. Recent randomised studies have lent weight to the use of dose intensified treatments in these selected patient groups...
March 21, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29552115/usefulness-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-lymphadenopathy
#6
Yuki Tanisaka, Shomei Ryozawa, Masanori Kobayashi, Maiko Harada, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Shin Arai, Kouichi Nonaka, Yumi Mashimo
Lymphadenopathy may be difficult to diagnose using imaging results alone. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) may help to diagnose and determine the appropriate management of lymphadenopathy. EUS-FNA has been used as a safe and less invasive method for obtaining pathologic specimens from extraluminal lesions using endoscopic ultrasound. The present study evaluated the usefulness of EUS-FNA for lymphadenopathy. Between July 2013 and December 2016, 72 patients undergoing EUS-FNA for lymphadenopathy that could not be diagnosed solely using imaging were included...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29519246/prostate-cancer-involving-bilateral-seminal-vesicles-along-with-bone-and-testicular-metastases-a-case-report
#7
Qingqiang Gao, Jianhuai Chen, Yutian Dai
BACKGROUND: In the past 20 years, the incidence of prostate cancer has risen rapidly. It has been ranked as the third most common malignant tumor of the male genitourinary system. Testicular metastasis is uncommon in prostate cancer. Most cases are incidentally found in the treatment of prostate cancer with orchiectomy. Therefore, we believed it was necessary to report the case of our patient with this disease. CASE PRESENTATION: We present a case of a 69-year-old Han Chinese man with a high total prostate-specific antigen level...
March 9, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29515971/the-expression-and-prognostic-impact-of-immune-cytolytic-activity-related-markers-in-human-malignancies-a-comprehensive-meta-analysis
#8
Constantinos Roufas, Dimitrios Chasiotis, Anestis Makris, Christodoulos Efstathiades, Christos Dimopoulos, Apostolos Zaravinos
Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). These levels are significantly elevated upon CD8+ T-cell activation as well as during a productive clinical response against immune-checkpoint blockade therapies...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29487620/retroperitoneal-lymph-node-dissection-as-primary-treatment-for-metastatic-seminoma
#9
REVIEW
Brian Hu, Siamak Daneshmand
Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-line treatment for seminoma with isolated lymph node metastasis to the retroperitoneum...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29485982/systemic-inflammatory-markers-have-independent-prognostic-value-in-patients-with-metastatic-testicular-germ-cell-tumours-undergoing-first-line-chemotherapy
#10
Christian Daniel Fankhauser, Sophia Sander, Lisa Roth, Oliver Gross, Daniel Eberli, Tullio Sulser, Burkhardt Seifert, Joerg Beyer, Thomas Hermanns
BACKGROUND: The prognostic utility of systemic inflammatory markers has so far not been investigated in patients with metastatic testicular germ cell tumours (GCTs). METHODS: International Germ Cell Cancer Cooperative Group (IGCCCG) risk groups and blood-based systemic inflammatory markers (haemoglobin, leukocytes, platelets (P), neutrophils (N), lymphocytes (L), C-reactive protein (CRP) and albumin) of 146 patients undergoing first-line chemotherapy for GCT were retrieved...
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29428550/a-new-model-to-predict-benign-histology-in-residual-retroperitoneal-masses-after-chemotherapy-in-nonseminoma
#11
Ricardo Leão, Madhur Nayan, Nahid Punjani, Michael A S Jewett, Kamel Fadaak, Juan Garisto, Jeremy Lewin, Eshetu G Atenafu, Joan Sweet, Lynn Anson-Cartwright, Peter Boström, Peter Chung, Padraig Warde, Philippe L Bedard, Aditya Bagrodia, Yuval Freifeld, Nicholas Power, Eric Winquist, Robert J Hamilton
BACKGROUND: Postchemotherapy retroperitoneal lymph node dissection (pcRPLND) is indicated in testicular cancer patients with normalised or plateaued serum tumour markers and residual retroperitoneal lesions >1cm. Challenges remain in predicting postchemotherapy residual mass (pcRM) histology, which may lead to unnecessary surgery. OBJECTIVE: To develop an accurate model to predict pcRM histology in patients with nonseminomatous germ cell tumours (NSGCTs). DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of 335 patients undergoing pcRPLND for metastatic NSGCTs to develop a model to predict benign histology in retroperitoneal pcRM...
February 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29405722/late-relapse-in-stage-i-of-nonseminomatous-germ-cell-testicular-cancer-on-surveillance
#12
M Ondrusova, M Suchansky, M Psota, T Zeleny, D Ondrus
OBJECTIVE: Primary aim was to assess relapse‑free survival (RFS) in patients with clinical stage I (CS I) of non-seminomatous germ cell testicular tumors (NSGCTT) undergoing surveillance after orchiectomy. The secondary aim was to examine differences in risk factors in patients with early relapse (ER 2 years) and very late relapse (VLR > 5 years). METHODS: Cross-sectional study analyzed 25‑year single‑center experiences with 198 CS I NSGCTT patients according the time to relapse...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29382456/a-contemporary-population-based-study-of-testicular-sex-cord-stromal-tumours-presentation-treatment-patterns-and-predictors-of-outcome
#13
Lindsay M Yuh, Primo N Lara, Rebecca M Wagenaar, Christopher P Evans, Marc A Dall'era, Rosemary Cress, Stanley A Yap
INTRODUCTION: We aimed to characterize demographic distribution, patient outcomes, and prognostic features of testicular sex cord stromal tumours (SCST) using a large statewide database. METHODS: Adult male patients diagnosed with SCST between 1988 and 2010 were identified within the California Cancer Registry (CCR). Baseline demographic variables and disease characteristics were reported. Primary outcome measures were cancer-specific survival (CSS) and overall survival (OS)...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29334543/seminoma-metastatic-to-the-orbit
#14
Jonathan J Dutton, Alan D Proia
PURPOSE: Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man. METHODS: A literature search was performed on the MEDLINE database using keywords "seminoma," "testicular germ-cell tumors," "testicular cancer," "testicular neoplasm," "orbital metastasis," and "germ-cell neoplasms...
January 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29295694/molecular-mechanisms-of-resistance-in-testicular-germ-cell-tumors-clinical-implications
#15
Katarina Kalavska, Vincenza Conteduca, Ugo De Giorgi, Michal Mego
Testicular germ cell tumors (TGCTs) represent the most common malignancy in men aged 15-35. Due to these tumors' biological and clinical characteristics, they can serve as an appropriate system for studying molecular mechanisms associated with cisplatin-based treatment resistance. This review describes treatment resistance from clinical and molecular viewpoints. Cisplatin resistance is determined by various biological mechanisms, including the modulation of the DNA repair capacity of cancer cells, alterations to apoptotic cell death pathways, deregulation of gene expression pathways, epigenetic alterations and insufficient DNA binding...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29250197/antiangiogenic-therapies-in-urogenital-malignancies-fiction-or-fact
#16
REVIEW
Friederike Haidl, David Pfister, Axel Heidenreich, Isabel Heidegger
The use of antiangiogenic agents in cancer therapy has become an attractive target in oncological research. However, concerning the uro-oncological field, current guidelines only recommend the use of antiangiogenic agents in metastatic renal cell cancer. Yet in recent years, several approaches for sequential treatment with angiogenesis inhibitors in other urogenital malignancies apart from renal cell cancer are ongoing. Thus, the present review article aims to provide an overview about clinical studies with antiangiogenic agents in prostate-, bladder-, testicular-, as well as penile cancer patients...
2017: Memo
https://www.readbyqxmd.com/read/29222199/treatment-of-cd30-expressing-germ-cell-tumors-and-sex-cord-stromal-tumors-with-brentuximab-vedotin-identification-and-report-of-seven-cases
#17
Costantine Albany, Lawrence Einhorn, Lawrence Garbo, Thomas Boyd, Neil Josephson, Darren R Feldman
BACKGROUND: Cytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates. Expression of CD30 has been observed in testicular cancers, and patients with CD30-expressing embryonal carcinomas have worse progression-free survival and overall survival than those with CD30-negative tumors. The objective of this study (NCT01461538) was to characterize the antitumor activity of brentuximab vedotin in patients with CD30-expressing nonlymphomatous malignancies...
March 2018: Oncologist
https://www.readbyqxmd.com/read/29173266/case-testicular-oligometastasis-from-prostate-cancer-report-of-rare-isolated-recurrence-after-radiotherapy-and-intermittent-androgen-deprivation-therapy
#18
Chan-Kyung J Cho, Samantha Sigurdson, Christopher M Davidson, Michael Leveridge, Aamer Mahmud
No abstract text is available yet for this article.
January 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29147133/allopurinol-in-combination-with-thiopurine-induces-mucosal-healing-and-improves-clinical-and-metabolic-outcomes-in-ibd
#19
Brigitte Moreau, Pierre Clement, Yves Theoret, Ernest G Seidman
Background: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine (6-MMP) while enhancing 6-thioguanine (6-TGN) levels. The aim of this study was to evaluate clinical, metabolic and endoscopic impact of allopurinol in combination with low-dose thiopurine in IBD...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29141221/chemotherapy-induced-depletion-of-oct4-positive-cancer-stem-cells-in-a-mouse-model-of-malignant-testicular-cancer
#20
Timothy M Pierpont, Amy M Lyndaker, Claire M Anderson, Qiming Jin, Elizabeth S Moore, Jamie L Roden, Alicia Braxton, Lina Bagepalli, Nandita Kataria, Hilary Zhaoxu Hu, Jason Garness, Matthew S Cook, Blanche Capel, Donald H Schlafer, Teresa Southard, Robert S Weiss
Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to conventional chemotherapy. To elucidate the underlying mechanisms, we developed a mouse TGCT model featuring germ cell-specific Kras activation and Pten inactivation. The resulting mice developed malignant, metastatic TGCTs composed of teratoma and embryonal carcinoma, the latter of which exhibited stem cell characteristics, including expression of the pluripotency factor OCT4. Consistent with epidemiological data linking human testicular cancer risk to in utero exposures, embryonic germ cells were susceptible to malignant transformation, whereas adult germ cells underwent apoptosis in response to the same oncogenic events...
November 14, 2017: Cell Reports
keyword
keyword
76461
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"