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https://www.readbyqxmd.com/read/28326199/predictors-of-recovery-from-traumatic-brain-injury-induced-prolonged-consciousness-disorder
#1
Hiroaki Abe, Keigo Shimoji, Yoshihide Nagamine, Satoru Fujiwara, Shin-Ichi Izumi
We investigated the clinical predictors of the degree of recovery in patients with prolonged disorders of consciousness (PDC) caused by traumatic brain injury. Fourteen patients with PDC underwent two diffusion tensor imaging (DTI) studies; the first and second scans were performed at 345.6 ± 192.6 and 689.1 ± 272.2 days after the injury, respectively. In addition to the temporal changes in each of these diffusion parameters, fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity were assessed over a 1-year period...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28322622/central-nervous-system-changes-induced-by-underbody-blast-induced-hyperacceleration-an-in-vivo-diffusion-tensor-imaging-and-magnetic-resonance-spectroscopy-study
#2
Shiyu Tang, Su Xu, William L Fourney, Ulrich H Leiste, Julie L Proctor, Gary Fiskum, Rao P Gullapalli
Blast-related traumatic brain injury (bTBI) resulting from improvised explosive devices is the hallmark injury of recent wars, and affects many returning veterans who experienced either direct or indirect exposure. Many of these veterans have long-term neurocognitive symptoms. However, there is very little evidence to show whether blast-induced acceleration alone, in the absence of secondary impacts, can cause mild TBI. In this study, we examine the effect of under-vehicle blast-induced hyperacceleration (uBIH) of ∼1700 g on the biochemical and microstrucutral changes in the brain using diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS)...
March 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28318507/usefulness-of-diffusion-tensor-mri-in-the-diagnosis-of-parkinson-variant-of-multiple-system-atrophy-and-parkinson-s-disease-a-valuable-tool-to-differentiate-between-them
#3
B Chen, G Fan, W Sun, X Shang, S Shi, S Wang, G Lv, C Wu
AIM: To evaluate the differences between patients with Parkinson's disease (PD) and Parkinson variant of multiple system atrophy (MSAp) at fractional anisotropy (FA) in the white matter when using the tract-based spatial statistics (TBSS) algorithm to provide objective markers for a differential diagnosis. MATERIALS AND METHODS: Diffusion-tensor imaging (DTI) data were acquired from 18 PD patients, 20 MSAp patients, and 24 healthy controls using a GE 3 T Signa HDx magnetic resonance imaging (MRI) system...
March 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28316255/a-bayesian-double-fusion-model-for-resting-state-brain-connectivity-using-joint-functional-and-structural-data
#4
Hakmook Kang, Hernando Ombao, Christopher Fonnesbeck, Zhaohua Ding, Victoria L Morgan
Current approaches separately analyze concurrently acquired diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) data. The primary limitation of these approaches is that they do not take advantage of the information from DTI that could potentially enhance estimation of resting state functional connectivity (FC) between brain regions. To overcome this limitation, we develop a Bayesian hierarchical spatio-temporal model that incorporates structural connectivity into estimating FC. In our proposed approach, structural connectivity (SC) based on DTI data is used to construct an informative prior for functional connectivity based on resting state fMRI data via the Cholesky decomposition...
March 19, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28315740/population-based-mri-and-dti-templates-of-the-adult-ferret-brain-and-tools-for-voxelwise-analysis
#5
E B Hutchinson, S C Schwerin, K L Radomski, N Sadeghi, J Jenkins, M E Komlosh, M O Irfanoglu, S L Juliano, C Pierpaoli
Non-invasive imaging has the potential to play a crucial role in the characterization and translation of experimental animal models to investigate human brain development and disorders, especially when employed to study animal models that more accurately represent features of human neuroanatomy. The purpose of this study was to build and make available MRI and DTI templates and analysis tools for the ferret brain as the ferret is a well-suited species for pre-clinical MRI studies with folded cortical surface, relatively high white matter volume and body dimensions that allow imaging with pre-clinical MRI scanners...
March 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28314375/inter-subject-variability-of-axonal-injury-in-diffuse-traumatic-brain-injury
#6
Jeffrey B Ware, Tessa Hart, John Whyte, Amanda Rabinowitz, John A Detre, Junghoon Kim
Traumatic brain injury (TBI) is a leading cause of cognitive morbidity worldwide, for which reliable biomarkers are needed. Diffusion tensor imaging (DTI) is a promising biomarker of traumatic axonal injury (TAI), however existing studies have been limited by a primary reliance upon group-level analytic methods not well-suited to account for inter-subject variability. In this study, 42 adults with TBI of at least moderate severity were examined 3 months following injury and compared to 35 healthy controls. DTI data was used for both traditional group-level comparison as well as subject-specific analysis using the distribution-corrected Z-score (DisCo-Z) approach...
March 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28301102/neural-correlates-of-language-variability-in-preschool-aged-boys-with-autism-spectrum-disorder
#7
Letitia R Naigles, Ryan Johnson, Ann Mastergeorge, Sally Ozonoff, Sally J Rogers, David G Amaral, Christine Wu Nordahl
Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL)...
March 16, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28298891/white-matter-deterioration-may-foreshadow-impairment-of-emotional-valence-determination-in-early-stage-dementia-of-the-alzheimer-type
#8
Ravi Rajmohan, Ronald C Anderson, Dan Fang, Austin G Meyer, Pavis Laengvejkal, Parunyou Julayanont, Greg Hannabas, Kitten Linton, John Culberson, Hafiz M R Khan, John De Toledo, P Hemachandra Reddy, Michael O'Boyle
In Alzheimer Disease (AD), non-verbal skills often remain intact for far longer than verbally mediated processes. Four (1 female, 3 males) participants with early-stage Clinically Diagnosed Dementia of the Alzheimer Type (CDDAT) and eight neurotypicals (NTs; 4 females, 4 males) completed the emotional valence determination test (EVDT) while undergoing BOLD functional magnetic resonance imaging (fMRI). We expected CDDAT participants to perform just as well as NTs on the EVDT, and to display increased activity within the bilateral amygdala and right anterior cingulate cortex (r-ACC)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28298033/diffusion-tractography-imaging-guided-frameless-linear-accelerator-stereotactic-radiosurgical-thalamotomy-for-tremor-case-report
#9
Won Kim, Justin Sharim, Stephen Tenn, Tania Kaprealian, Yvette Bordelon, Nzhde Agazaryan, Nader Pouratian
Essential tremor and Parkinson's disease-associated tremor are extremely prevalent within the field of movement disorders. The ventral intermediate (VIM) nucleus of the thalamus has been commonly used as both a neuromodulatory and neuroablative target for the treatment of these forms of tremor. With both deep brain stimulation and Gamma Knife radiosurgery, there is an abundance of literature regarding the surgical planning, targeting, and outcomes of these methodologies. To date, there have been no reports of frameless, linear accelerator (LINAC)-based thalomotomies for tremor...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28294462/disruption-of-white-matter-structural-integrity-and-connectivity-in-posttraumatic-stress-disorder-a-tbss-and-tractography-study
#10
Elizabeth A Olson, Jiaolong Cui, Rena Fukunaga, Lisa D Nickerson, Scott L Rauch, Isabelle M Rosso
BACKGROUND: Most studies of brain white matter (WM) in posttraumatic stress disorder (PTSD) have focused on combat trauma, and often were confounded by neurological and substance dependence comorbidity. This study used tract-based spatial statistics (TBSS) and probabilistic tractography to characterize WM microstructure in a mixed-sex community sample of PTSD patients exposed to diverse and multiple traumas, and in trauma-exposed normal comparison (TENC) subjects. METHODS: TBSS compared diffusion measures between 20 adults with DSM-IV PTSD and 17 TENC, using a whole-brain voxel-wise approach...
March 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28293162/ensemble-classification-of-alzheimer-s-disease-and-mild-cognitive-impairment-based-on-complex-graph-measures-from-diffusion-tensor-images
#11
Ashkan Ebadi, Josué L Dalboni da Rocha, Dushyanth B Nagaraju, Fernanda Tovar-Moll, Ivanei Bramati, Gabriel Coutinho, Ranganatha Sitaram, Parisa Rashidi
The human brain is a complex network of interacting regions. The gray matter regions of brain are interconnected by white matter tracts, together forming one integrative complex network. In this article, we report our investigation about the potential of applying brain connectivity patterns as an aid in diagnosing Alzheimer's disease and Mild Cognitive Impairment (MCI). We performed pattern analysis of graph theoretical measures derived from Diffusion Tensor Imaging (DTI) data representing structural brain networks of 45 subjects, consisting of 15 patients of Alzheimer's disease (AD), 15 patients of MCI, and 15 healthy subjects (CT)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28291839/microstructural-white-matter-alterations-in-preclinical-alzheimer-s-disease-detected-using-free-water-elimination-diffusion-tensor-imaging
#12
Andrew R Hoy, Martina Ly, Cynthia M Carlsson, Ozioma C Okonkwo, Henrik Zetterberg, Kaj Blennow, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Andrew L Alexander, Barbara B Bendlin
Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and synaptic pathology are closely related to the cognitive dysfunction. Brain imaging methods that are tuned to assess degeneration of myelinated nerve fibers in the brain (collectively called white matter) include diffusion tensor imaging (DTI) and related techniques, and are expected to shed light on disease-related loss of structural connectivity...
2017: PloS One
https://www.readbyqxmd.com/read/28290074/abnormal-brain-white-matter-network-in-young-smokers-a-graph-theory-analysis-study
#13
Yajuan Zhang, Min Li, Ruonan Wang, Yanzhi Bi, Yangding Li, Zhang Yi, Jixin Liu, Dahua Yu, Kai Yuan
Previous diffusion tensor imaging (DTI) studies had investigated the white matter (WM) integrity abnormalities in some specific fiber bundles in smokers. However, little is known about the changes in topological organization of WM structural network in young smokers. In current study, we acquired DTI datasets from 58 male young smokers and 51 matched nonsmokers and constructed the WM networks by the deterministic fiber tracking approach. Graph theoretical analysis was used to compare the topological parameters of WM network (global and nodal) and the inter-regional fractional anisotropy (FA) weighted WM connections between groups...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28290072/changes-in-brain-white-matter-integrity-after-systemic-treatment-for-breast-cancer-a-prospective-longitudinal-study
#14
Sanne Menning, Michiel B de Ruiter, Dick J Veltman, Willem Boogerd, Hester S A Oldenburg, Liesbeth Reneman, Sanne B Schagen
An increasing number of studies suggest chemotherapy for breast cancer may be neurotoxic. Cross-sectional MRI diffusion tensor imaging (DTI) studies suggest a vulnerability of brain white matter to various chemotherapeutic regimens. Up till now, this was confirmed in one prospective DTI study: Deprez et al. (2012) showed a widespread decline in fractional anisotropy (FA) of breast cancer patients after chemotherapy consisting of 5-fluorouracil (5-FU), epirubicin and cyclophosphamide (FEC) +/- taxanes +/- endocrine treatment...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28289648/diagnostic-challenge-of-diffusion-tensor-imaging-in-a-patient-with-hemiplegia-after-traumatic-brain-injury
#15
Hye Eun Shin, Hoon Chang Suh, Si Hyun Kang, Kyung Mook Seo, Don-Kyu Kim, Hae-Won Shin
A 51-year-old man showed hemiplegia on his right side after a traumatic brain injury (TBI). On initial brain computed tomography (CT) scan, an acute subdural hemorrhage in the right cerebral convexity and severe degrees of midline shifting and subfalcine herniation to the left side were evident. On follow-up brain magnetic resonance imaging (MRI), there were multiple microhemorrhages in the left parietal and occipital subcortical regions. To explain the occurrence of right hemiplegia after brain damage which dominantly on the right side of brain, we used diffusion tensor imaging (DTI) to reconstruct the corticospinal tract (CST), which showed nearly complete injury on the left CST...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28286008/compound-heterozygous-variants-in-robo1-cause-a-neurodevelopmental-disorder-with-absence-of-transverse-pontine-fibers-and-thinning-of-the-anterior-commissure-and-corpus-callosum
#16
Sonia F Calloni, Julie S Cohen, Avner Meoded, Jane Juusola, Fabio M Triulzi, Thierry A G M Huisman, Andrea Poretti, Ali Fatemi
BACKGROUND: Axonal guidance disorders are characterized by white matter tracts with an anomalous course, failure to cross the midline, or presence of anomalous white matter tracts. Diffusion tensor imaging (DTI) is a suitable noninvasive, in vivo neuroimaging tool to study axonal guidance disorders. We describe a novel disorder in a boy with compound heterozygous variants in the ROBO1 gene. PATIENT DESCRIPTION: The child was referred at age 13 months because of developmental delay...
February 2, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28283867/postoperative-neuroimaging-analysis-of-drt-deep-brain-stimulation-revision-surgery-for-complicated-essential-tremor
#17
Volker Arnd Coenen, Balint Varkuti, Yaroslav Parpaley, Sabine Skodda, Thomas Prokop, Horst Urbach, Meng Li, Peter Christoph Reinacher
BACKGROUND: We report a patient who received conventional bilateral deep brain stimulation of the ventral intermediate nucleus of thalamus (Vim) for the treatment of medication refractory essential tremor (ET). After initial beneficial effects, therapeutic efficacy was lost due to a loss of control of his proximal trunkal and extremity tremor. The patient received successful diffusion tensor magnetic resonance imaging fiber tractographic (DTI FT)-assisted DBS revision surgery targeting the dentato-rubro-thalamic tract (DRT) in the subthalamic region (STR)...
March 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28283747/magnetic-resonance-diffusion-tensor-imaging-for-the-pedunculopontine-nucleus-proof-of-concept-and-histological-correlation
#18
A T D L Alho, C Hamani, E J L Alho, R E da Silva, G A B Santos, R C Neves, L L Carreira, C M M Araújo, G Magalhães, D B Coelho, M C Alegro, M G M Martin, L T Grinberg, C A Pasqualucci, H Heinsen, E T Fonoff, E Amaro
The pedunculopontine nucleus (PPN) has been proposed as target for deep brain stimulation (DBS) in patients with postural instability and gait disorders due to its involvement in muscle tonus adjustments and control of locomotion. However, it is a deep-seated brainstem nucleus without clear imaging or electrophysiological markers. Some studies suggested that diffusion tensor imaging (DTI) may help guiding electrode placement in the PPN by showing the surrounding fiber bundles, but none have provided a direct histological correlation...
March 10, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28274963/mri-based-comparative-study-of-different-mild-cognitive-impairment-subtypes-protocol-for-an-observational-case-control-study
#19
Yang Yu, Weina Zhao, Siou Li, Changhao Yin
INTRODUCTION: Amnestic mild cognitive impairment (aMCI) and vascular mild cognitive impairment (VaMCI) comprise the 2 main types of mild cognitive impairment (MCI). The first condition generally progresses to Alzheimer's disease, whereas the second is likely to develop into vascular dementia (VD). The brain structure and function of patients with MCI differ from those of normal elderly individuals. However, whether brain structures or functions differ between these 2 MCI subtypes has not been studied...
March 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28271440/global-white-matter-microstructural-abnormalities-associated-with-addiction-liability-score-in-drug-na%C3%A3-ve-youth
#20
Leslie Hulvershorn, Tom Hummer, Yu-Chien Wu, Ralph Tarter, Parker Rea, Amit Anand, R Andrew Chambers, Peter Finn
Abnormalities in brain white matter (WM) structure have been reported in youths having a family history of substance use disorders (SUDs). It was hypothesized that these abnormalities constitute features of the liability for SUDs transmitted across generations. The association between severity of intergenerational risk for SUD, measured by the Transmissible Liability Index (TLI), and white matter microstructure was examined. Diffusion tensor imaging (DTI) measured WM microstructure in forty-four drug-naïve 10-14 year-olds (N = 19 with parental SUD)...
March 7, 2017: Brain Imaging and Behavior
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