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https://www.readbyqxmd.com/read/28550466/schizophrenia-symptomatic-associations-with-diffusion-tensor-imaging-measured-fractional-anisotropy-of-brain-a-meta-analysis
#1
Xu Yang, Ding Cao, Xiumei Liang, Jiannong Zhao
PURPOSE: Several studies have examined the relationships between diffusion tensor imaging (DTI)-measured fractional anisotropy (FA) and the symptoms of schizophrenia, but results vary across the studies. The aim of this study was to carry out a meta-analysis of correlation coefficients reported by relevant studies to evaluate the correlative relationships between FA of various parts of the brain and schizophrenia symptomatic assessments. METHODS: Literature was searched in several electronic databases, and study selection was based on précised eligibility criteria...
May 26, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28546311/evidence-for-functional-networks-within-the-human-brain-s-white-matter
#2
Michael Peer, Mor Nitzan, Atira S Bick, Netta Levin, Shahar Arzy
Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. While numerous studies have identified networks of interacting functional modules in the grey-matter, limited research was directed to the functional organization of the white-matter. Recent studies have demonstrated that the white-matter exhibits blood oxygen level dependent (BOLD) signal fluctuations similar to those of the grey-matter. Here we used these signal fluctuations to investigate whether the white-matter is organized as functional networks by applying a clustering analysis on resting-state functional MRI (RSfMRI) data from white-matter voxels, in 176 subjects (of both sexes)...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28543952/structural-signature-of-classical-versus-late-onset-friedreich-s-ataxia-by-multimodality-brain-mri
#3
Thiago Junqueira R Rezende, Alberto Rolim M Martinez, Ingrid Faber, Karen Girotto, José Luiz Pedroso, Orlando G Barsottini, Iscia Lopes-Cendes, Fernando Cendes, Andreia V Faria, Marcondes C França
INTRODUCTION: Friedreich's ataxia (FRDA) is the most common autosomal-recessive ataxia worldwide. It is characterized by early onset, sensory abnormalities, and slowly progressive ataxia. However, some individuals manifest the disease after the age of 25 years and are classified as late-onset FRDA (LOFA). Therefore, we propose a transversal multimodal MRI-based study to investigate which anatomical substrates are involved in classical (cFRDA) and LOFA. METHODS: We enrolled 36 patients (13 with LOFA) and 29 healthy controls...
May 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28522663/the-use-of-noncontrast-quantitative-mri-to-detect-gadolinium-enhancing-multiple-sclerosis-brain-lesions-a-systematic-review-and-meta-analysis
#4
A Gupta, K Al-Dasuqi, F Xia, G Askin, Y Zhao, D Delgado, Y Wang
BACKGROUND: Concerns have arisen about the long-term health effects of repeat gadolinium injections in patients with multiple sclerosis and the incomplete characterization of MS lesion pathophysiology that results from relying on enhancement characteristics alone. PURPOSE: Our aim was to perform a systematic review and meta-analysis analyzing whether noncontrast MR imaging biomarkers can distinguish enhancing and nonenhancing brain MS lesions. DATA SOURCES: Our sources were Ovid MEDLINE, Ovid Embase, and the Cochrane data base from inception to August 2016...
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28520647/altered-brain-structure-and-function-associated-with-sensory-and-affective-components-of-classic-trigeminal-neuralgia
#5
Yuan Wang, Dong-Yuan Cao, Bethany Remeniuk, Samuel Krimmel, David A Seminowicz, Ming Zhang
Classic trigeminal neuralgia (CTN) is a chronic neuropathic pain state characterized by intense, piercing spasms of the orofacial region, and may be attributable to abnormal pain processing in the central nervous system. Our study investigated neuronal alterations using voxel-based morphometry (VBM), diffuse tensor imaging (DTI), and resting state functional connectivity in 38 CTN patients and 38 matched healthy controls. For VBM analyses, CTN patients displayed gray matter volume (GMV) reductions in the anterior and mid cingulate cortex (ACC and MCC), insula, secondary somatosensory cortex (S2), primary motor cortex (M1), premotor area (PMA), and several regions in the temporal lobe...
May 16, 2017: Pain
https://www.readbyqxmd.com/read/28516143/change-point-analysis-data-of-neonatal-diffusion-tensor-mri-in-preterm-and-term-born-infants
#6
Dan Wu, Linda Chang, Kentaro Akazawa, Kumiko Oishi, Jon Skranes, Thomas Ernst, Kenichi Oishi
The data presented in this article are related to the research article entitled "Mapping the Critical Gestational Age at Birth that Alters Brain Development in Preterm-born Infants using Multi-Modal MRI" (Wu et al., 2017) [1]. Brain immaturity at birth poses critical neurological risks in the preterm-born infants. We used a novel change-point model to analyze the critical gestational age at birth (GAB) that could affect postnatal development, based on diffusion tensor MRI (DTI) acquired from 43 preterm and 43 term-born infants in 126 brain regions...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28505976/in-vivo-detection-of-gray-matter-neuropathology-in-the-3xtg-mouse-model-of-alzheimer-s-disease-with-diffusion-tensor-imaging
#7
Wanda M Snow, Ryan Dale, Zoe O'Brien-Moran, Richard Buist, Danial Peirson, Melanie Martin, Benedict C Albensi
A diagnosis of Alzheimer's disease (AD), a neurodegenerative disorder accompanied by severe functional and cognitive decline, is based on clinical findings, with final confirmation of the disease at autopsy by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles. Given that microstructural brain alterations occur years prior to clinical symptoms, efforts to detect brain changes early could significantly enhance our ability to diagnose AD sooner. Diffusion tensor imaging (DTI), a type of MRI that characterizes the magnitude, orientation, and anisotropy of the diffusion of water in tissues, has been used to infer neuropathological changes in vivo...
May 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28502079/microstructure-alterations-in-the-hypothalamus-in-cranially-radiated-childhood-leukemia-survivors-but-not-in-craniopharyngioma-patients-unaffected-by-hypothalamic-damage
#8
Cecilia Follin, Sigridur Fjalldal, Daniel Svärd, Danielle van Westen, Sanaz Gabery, Åsa Petersén, Jimmy Lätt, Lars Rylander, Eva Marie Erfurth
OBJECTIVE: Metabolic complications are frequent in childhood leukemia (ALL) survivors treated with cranial radiotherapy (CRT). These complications are potentially mediated by damage to the hypothalamus (HT), as childhood onset (CO) craniopharyngioma (CP) survivors without HT involvement are spared overt obesity. Diffusion tensor imaging (DTI) shows brain tissue microstructure alterations, by fractional anisotrophy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)...
May 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28501904/relationship-between-perisylvian-essential-language-sites-and-arcuate-fasciculus-in-the-left-hemisphere-of-healthy-adults
#9
Yu Lin, Kai Zhang, Shuai Li, Song Li, Jingna Jin, Fang Jin, Wen Qin, Long Hai, Meng Zhu, Chunshui Yu, Zhipeng Liu, Tao Yin, Xuejun Yang
Essential language sites and the arcuate fasciculus (AF) have been extensively researched. However, the relationship between them remains insufficiently studied, especially in healthy people. Navigated transcranial magnetic stimulation (nTMS) is increasingly used in language mapping. While enjoying the advantage of non-invasiveness, it is also capable of inducing a virtual lesion in the brain. Thus, it offers the possibility of using the virtual-lesion method to study the healthy brain. This study combined nTMS and diffusion tensor imaging (DTI) tractography to investigate the relationship between essential language sites and the AF in 30 healthy right-handed volunteers...
May 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28500983/night-sleep-influences-white-matter-microstructure-in-bipolar-depression
#10
Francesco Benedetti, Elisa M T Melloni, Sara Dallaspezia, Irene Bollettini, Clara Locatelli, Sara Poletti, Cristina Colombo
BACKGROUND: Alteration of circadian rhythms and sleep disruption are prominent trait-like features of bipolar disorder (BD). Diffusion tensor imaging (DTI) measures suggest a widespread alteration of white matter (WM) microstructure in patients with BD. Sleep promotes myelination and oligodendrocyte precursor cells proliferation. We hypothesized a possible association between DTI measures of WM microstructure and sleep quantity measures in BD. METHODS: We studied 69 inpatients affected by a depressive episode in course of type I BD...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28498501/ppar-gamma-agonist-pioglitazone-modifies-craving-intensity-and-brain-white-matter-integrity-in-patients-with-primary-cocaine-use-disorder-a-double-blind-randomized-controlled-pilot-trial
#11
Joy M Schmitz, Charles E Green, Khader M Hasan, Jessica Vincent, Robert Suchting, Michael F Weaver, F Gerard Moeller, Ponnada A Narayana, Kathryn A Cunningham, Kelly T Dineley, Scott D Lane
BACKGROUND AND AIMS: Pioglitazone (PIO), a potent agonist of PPAR-gamma, is a promising candidate treatment for cocaine use disorder (CUD). We tested the effects of PIO on targeted mechanisms relevant to CUD: cocaine craving and brain white matter (WM) integrity. Feasibility, medication compliance, and tolerability were evaluated. DESIGN: Two-arm double-blind randomized controlled proof-of-concept pilot trial of PIO or placebo (PLC). SETTING: Single-site outpatient treatment research clinic in Houston, Texas, USA...
May 12, 2017: Addiction
https://www.readbyqxmd.com/read/28498274/fornix-structural-connectivity-and-allostatic-load-empirical-evidence-from-schizophrenia-patients-and-healthy-controls
#12
Anya Savransky, Joshua Chiappelli, Laura M Rowland, Krista Wisner, Dinesh K Shukla, Peter Kochunov, L Elliot Hong
OBJECTIVE: The fornix is a white matter tract carrying the fibers connecting the hippocampus and the hypothalamus, two essential stress-regulatory structures of the brain. We tested the hypothesis that allostatic load (AL), derived from a battery of peripheral biomarkers indexing the cumulative effects of stress, is associated with abnormalities in brain white matter microstructure, especially the fornix; and that higher AL may help explain the white matter abnormalities in schizophrenia...
May 12, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28496398/growth-of-thalamocortical-fibers-to-the-somatosensory-cortex-in-the-human-fetal-brain
#13
Željka Krsnik, Visnja Majić, Lana Vasung, Hao Huang, Ivica Kostović
Thalamocortical (TH-C) fiber growth begins during the embryonic period and is completed by the third trimester of gestation in humans. Here we determined the timing and trajectories of somatosensory TH-C fibers in the developing human brain. We analyzed the periods of TH-C fiber outgrowth, path-finding, "waiting" in the subplate (SP), target selection, and ingrowth in the cortical plate (CP) using histological sections from post-mortem fetal brain [from 7 to 34 postconceptional weeks (PCW)] that were processed with acetylcholinesterase (AChE) histochemistry and immunohistochemical methods...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28487471/using-dti-to-assess-white-matter-microstructure-in-cerebral-small-vessel-disease-svd-in-multi-centre-studies
#14
Iain David Croall, Valerie Lohner, Barry Moynihan, Usman Khan, Ahamad Hassan, John T O'Brien, Robin G Morris, Daniel J Tozer, Victoria C Cambridge, Kirsty Harkness, David Werring, Andrew M Blamire, Gary A Ford, Thomas R Barrick, Hugh S Markus
Diffusion tensor imaging (DTI) metrics such as Fractional Anisotropy (FA) and Mean Diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease due to their associations with outcomes such as cognition. However, studies investigating this have been predominantly single-centre. As clinical trials are likely to be multi-site, further studies are required to determine whether associations with cognition of similar strength can be detected in a multi-centre setting. 109 patients (mean age=68) with symptomatic lacunar infarction and confluent white matter hyperintensities (WMH) on MRI was recruited across 6 sites as part of the PRESERVE DTI sub-study...
May 9, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28484386/the-integrity-of-the-corpus-callosum-mitigates-the-impact-of-blood-pressure-on-the-ventral-attention-network-and-information-processing-speed-in-healthy-adults
#15
Nichol M L Wong, Ernie Po-Wing Ma, Tatia M C Lee
Hypertension is a risk factor for cognitive impairment in older age. However, evidence of the neural basis of the relationship between the deterioration of cognitive function and elevated blood pressure is sparse. Based on previous research, we speculate that variations in brain connectivity are closely related to elevated blood pressure even before the onset of clinical conditions and apparent cognitive decline in individuals over 60 years of age. Forty cognitively healthy adults were recruited. Each received a blood pressure test before and after the cognitive assessment in various domains...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28484382/structural-alterations-in-the-corpus-callosum-are-associated-with-suicidal-behavior-in-women-with-borderline-personality-disorder
#16
Alexander Lischke, Martin Domin, Harald J Freyberger, Hans J Grabe, Renate Mentel, Dorothee Bernheim, Martin Lotze
Structural alterations in the corpus callosum (CC), the major white matter tract connecting functionally related brain regions in the two hemispheres, have been shown to be associated with emotional instability, impulsivity and suicidality in various mental disorders. To explore whether structural alterations of the CC would be similarly associated with emotional instability, impulsivity and suicidality in borderline personality disorder (BPD), we used diffusion tensor imaging (DTI) to assess the structural integrity of the CC in 21 BPD and 20 healthy control (HC) participants...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28482644/olfactory-impairment-in-parkinson-s-disease-studied-with-diffusion-tensor-and%C3%A2-magnetization-transfer-imaging
#17
Charalampos Georgiopoulos, Marcel Warntjes, Nil Dizdar, Helene Zachrisson, Maria Engström, Sven Haller, Elna-Marie Larsson
BACKGROUND: Olfactory impairment is an early manifestation of Parkinson's disease (PD). Diffusion Tensor Imaging (DTI) and Magnetization Transfer (MT) are two imaging techniques that allow noninvasive detection of microstructural changes in the cerebral white matter. OBJECTIVE: To assess white matter alterations associated with olfactory impairment in PD, using a binary imaging approach with DTI and MT. METHODS: 22 PD patients and 13 healthy controls were examined with DTI, MT and an odor discrimination test...
May 5, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28474309/preoperative-prediction-of-language-function-by-diffusion-tensor-imaging
#18
C F Freyschlag, J Kerschbaumer, D Pinggera, T Bodner, A E Grams, C Thomé
For surgery of eloquent tumors in language areas, the accepted gold standard is functional mapping through direct cortical stimulation (DCS) in awake patients. Ever since, neuroscientists are searching for reliable noninvasive detection of function in the human brain, with variable success. The potential of diffusion tensor imaging (DTI) in combination with computational cortical parcellation to predict functional areas in language eloquent tumors has not been assessed so far. We present a proof-of-concept report involving awake surgery for a temporodorsal tumor...
May 4, 2017: Brain Informatics
https://www.readbyqxmd.com/read/28470928/longitudinal-differences-in-white-matter-integrity-in-youth-at-high-familial-risk-for-bipolar-disorder
#19
Rossana Ganzola, Thomas Nickson, Mark E Bastin, Stephen Giles, Alix Macdonald, Jessika Sussmann, Andrew M McIntosh, Heather C Whalley, Simon Duchesne
OBJECTIVES: Previous neuroimaging studies have reported abnormalities in white matter (WM) pathways in subjects at high familial risk of mood disorders. In the current study, we examined the trajectory of these abnormalities during the early stages of illness development using longitudinal diffusion tensor imaging (DTI) data. METHODS: Subjects (16-28 years old) were recruited in the Scottish Bipolar Family Study, a prospective longitudinal study that has examined individuals at familial risk of mood disorder on three occasions, 2 years apart...
May 3, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28470878/gray-matter-abnormalities-in-idiopathic-parkinson-s-disease-evaluation-by-diffusional-kurtosis-imaging-and-neurite-orientation-dispersion-and-density-imaging
#20
Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques is essential to facilitate early diagnosis and assessment of disease severity. GM microstructure was assessed with GM-based spatial statistics applied to diffusion kurtosis imaging (DKI) and neurite orientation dispersion imaging (NODDI) in 30 participants with PD and 28 age- and gender-matched controls. These were compared with currently used assessment methods such as diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based cortical thickness analysis...
May 4, 2017: Human Brain Mapping
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