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https://www.readbyqxmd.com/read/28725550/dti-measures-identify-mild-and-moderate-tbi-cases-among-patients-with-complex-health-problems-a-receiver-operating-characteristic-analysis-of-u-s-veterans
#1
Keith L Main, Salil Soman, Franco Pestilli, Ansgar Furst, Art Noda, Beatriz Hernandez, Jennifer Kong, Jauhtai Cheng, Jennifer K Fairchild, Joy Taylor, Jerome Yesavage, J Wesson Ashford, Helena Kraemer, Maheen M Adamson
Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts are most pertinent to TBI diagnosis. This study ranked fiber tracts on their ability to discriminate patients with and without TBI. We acquired diffusion tensor imaging data from military veterans admitted to a polytrauma clinic (Overall n = 109; Age: M = 47...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28720778/visualization-of-kidney-fibrosis-in-diabetic-nephropathy-by-long-diffusion-tensor-imaging-mri-with-spin-echo-sequence
#2
Jun-Ya Kaimori, Yoshitaka Isaka, Masaki Hatanaka, Satoko Yamamoto, Naotsugu Ichimaru, Akihiko Fujikawa, Hiroshi Shibata, Akira Fujimori, Sosuke Miyoshi, Takashi Yokawa, Kagayaki Kuroda, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara
Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a special kidney attachment was developed for long-term stabilization...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717361/research-of-hubs-location-method-for-weighted-brain-network-based-on-nos-fa
#3
Zhengkui Weng, Bin Wang, Jie Xue, Baojie Yang, Hui Liu, Xin Xiong
As a complex network of many interlinked brain regions, there are some central hub regions which play key roles in the structural human brain network based on T1 and diffusion tensor imaging (DTI) technology. Since most studies about hubs location method in the whole human brain network are mainly concerned with the local properties of each single node but not the global properties of all the directly connected nodes, a novel hubs location method based on global importance contribution evaluation index is proposed in this study...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28713258/relationship-of-topology-multiscale-phase-synchronization-and-state-transitions-in-human-brain-networks
#4
Minkyung Kim, Seunghwan Kim, George A Mashour, UnCheol Lee
How the brain reconstitutes consciousness and cognition after a major perturbation like general anesthesia is an important question with significant neuroscientific and clinical implications. Recent empirical studies in animals and humans suggest that the recovery of consciousness after anesthesia is not random but ordered. Emergence patterns have been classified as progressive and abrupt transitions from anesthesia to consciousness, with associated differences in duration and electroencephalogram (EEG) properties...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28712716/differentiation-of-glioma-malignancy-grade-using-diffusion-mri
#5
Ivan I Maximov, Aram S Tonoyan, Igor N Pronin
Modern diffusion MR protocols allow one to acquire the multi-shell diffusion data with high diffusion weightings in a clinically feasible time. In the present work we assessed three diffusion approaches based on diffusion and kurtosis tensor imaging (DTI, DKI), and neurite orientation dispersion and density imaging (NODDI) as possible biomarkers for human brain glioma grade differentiation based on the one diffusion protocol. We used three diffusion weightings (so called b-values) equal to 0, 1000, and 2500s/mm(2) with 60 non-coplanar diffusion directions in the case of non-zero b-values...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28712330/the-role-of-abnormalities-in-the-corpus-callosum-in-social-cognition-deficits-after-traumatic-brain-injury
#6
Skye McDonald, Jacqueline A Rushby, Katie I Dalton, Samantha K Allen, Nicklas Parks
The corpus callosum (CC) is vulnerable to severe traumatic brain injury (TBI). Social cognition requires integration of non-verbal and verbal information in order to understand social behaviour and may be compromised if the CC is damaged. 17 adults with severe, chronic TBI and 17 control participants underwent structural MRI and Diffusion Tensor Imaging. A region of interest analysis examined fractional anisotropy (FA) and mean diffusivity (MD) across regions of the CC. Performance on The Awareness of Social Inference Test (TASIT): part 1 (emotion recognition) and parts 2 and 3 (social inference), was examined in relation to FA and MD...
July 17, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28706473/short-term-internet-search-training-is-associated-with-increased-fractional-anisotropy-in-the-superior-longitudinal-fasciculus-in-the-parietal-lobe
#7
Guangheng Dong, Hui Li, Marc N Potenza
The Internet search engine has become an indispensable tool for many people, yet the ways in which Internet searching may alter brain structure and function is poorly understood. In this study, we investigated the influence of short-term Internet-search "training" on white matter microstructure using diffusion tensor imaging (DTI). Fifty-nine valid subjects (Experimental group, 43; Control group, 16) completed the whole procedure: pre- DTI scan, 6-day's training and post- DTI scan. Using track-based spatial statistics, we found increased fractional anisotropy in the right superior longitudinal fasciculus at post-test as compared to pre-test in experimental group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28700727/longitudinal-increases-of-brain-metabolite-levels-in-5-10-year-old-children
#8
Martha J Holmes, Frances C Robertson, Francesca Little, Steven R Randall, Mark F Cotton, Andre J W van der Kouwe, Barbara Laughton, Ernesta M Meintjes
Longitudinal magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) studies reveal significant changes in brain structure and structural networks that occur together with cognitive and behavioral maturation in childhood. However, the underlying cellular changes accompanying brain maturation are less understood. Examining regional age-related changes in metabolite levels provides insight into the physiology of neurodevelopment. Magnetic resonance spectroscopy (MRS) measures localize brain metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28698090/the-superior-frontal-transsulcal-approach-to-the-anterior-ventricular-system-exploring-the-sulcal-and-subcortical-anatomy-using-anatomic-dissections-and-dti-tractography
#9
Christos Koutsarnakis, Faidon Liakos, Aristotelis V Kalyvas, Georgios P Skandalakis, Spyros Komaitis, Fotini Christidi, Efstratios Karavasilis, Evangellia Liouta, George Stranjalis
OBJECTIVE: To explore the superior frontal sulcus morphology, trajectory of the applied surgical corridor and white matter bundles that are traversed during the superior frontal transsulcal transventricular approach METHODS: Twenty (20) normal, adult, formalin-fixed cerebral hemispheres and two (2) cadaveric heads were included in the study. The superior frontal sulcus (SFS) topography, morphology and dimensions were recorded in all specimens. Fourteen (14) hemispheres were investigated through the fiber dissection technique while the remaining six (6) were explored using coronal cuts...
July 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28695759/diffusion-tensor-imaging-findings-suggestive-of-white-matter-alterations-in-a-canine-model-of-mucopolysaccharidosis-type-i
#10
Dana M Middleton, Jonathan Y Li, Steven D Chen, Leonard E White, Patricia Dickson, N Matthew Ellinwood, James M Provenzale
Purpose We investigated fractional anisotropy (FA) and radial diffusivity (RD) in a canine model of mucopolysaccharidosis (MPS). We hypothesized that canines affected with MPS would exhibit decreased FA and increased RD values when compared to unaffected canines, a trend that has been previously described in humans with white matter diseases. Methods Four unaffected canines and two canines with MPS were euthanized at 18 weeks of age. Their brains were imaged using high-resolution diffusion tensor imaging (DTI) on a 7T small-animal magnetic resonance imaging system...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28688263/white-matter-correlates-of-impaired-attention-control-in-major-depressive-disorder-and-healthy-volunteers
#11
Mina M Rizk, Harry Rubin-Falcone, John Keilp, Jeffrey M Miller, M Elizabeth Sublette, Ainsley Burke, Maria A Oquendo, Ahmed M Kamal, Mohamed A Abdelhameed, J John Mann
BACKGROUND: Major depressive disorder (MDD) is associated with impaired attention control and alterations in frontal-subcortical connectivity. We hypothesized that attention control as assessed by Stroop task interference depends on white matter integrity in fronto-cingulate regions and assessed this relationship using diffusion tensor imaging (DTI) in MDD and healthy volunteers (HV). METHODS: DTI images and Stroop task were acquired in 29 unmedicated MDD patients and 16 HVs, aged 18-65 years...
June 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28684860/neuroinflammation-in-obesity-circulating-lipopolysaccharide-binding-protein-associates-with-brain-structure-and-cognitive-performance
#12
J M Moreno-Navarrete, G Blasco, J Puig, C Biarnés, M Rivero, J Gich, F Fernández-Aranda, J Garre-Olmo, L Ramió-Torrentà, Á Alberich-Bayarri, F G Castro, S Pedraza, W Ricart, J M Fernández-Real
BACKGROUND/OBJECTIVES: Growing evidence implicates neuroinflammation in the pathogenesis of diet-induced obesity and cognitive dysfunction in rodent models. Obesity is associated with reduced white matter integrity and cognitive decline. Circulating lipopolysaccharide binding protein (LBP) concentration is known to be increased in patients with obesity. Here, we aimed to evaluate whether circulating LBP is associated longitudinally with white matter structure and cognitive performance according to obesity status...
July 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28681960/the-anatomical-scaffold-underlying-the-functional-centrality-of-known-cortical-hubs
#13
Francesco de Pasquale, Stefania Della Penna, Umberto Sabatini, Chiara Caravasso Falletta, Patrice Peran
Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously reshape structural and functional connections. Thus, if hubs are expected to exhibit a large number of direct anatomical connections with the rest of the brain, such a dense wiring is extremely inefficient in energetic terms...
July 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28677058/structural-changes-in-parkinson-s-disease-voxel-based-morphometry-and-diffusion-tensor-imaging-analyses-based-on-123-i-mibg-uptake
#14
Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryo Somehara, Ryotaro Kamei, Shingo Baba, Hiroo Yamaguchi, Jun-Ichi Kira, Hiroshi Honda
OBJECTIVE: Patients with Parkinson's disease (PD) may exhibit symptoms of sympathetic dysfunction that can be measured using (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. We investigated the relationship between microstructural brain changes and (123)I-MIBG uptake in patients with PD using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) analyses. METHODS: This retrospective study included 24 patients with PD who underwent 3 T magnetic resonance imaging and (123)I-MIBG scintigraphy...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28676987/white-matter-abnormalities-in-mild-traumatic-brain-injury-with-and-without-post-traumatic-stress-disorder-a-subject-specific-diffusion-tensor-imaging-study
#15
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28671333/diffusion-tensor-imaging-studies-of-attention-deficit-hyperactivity-disorder-meta-analyses-and-reflections-on-head-motion
#16
Yuta Aoki, Samuele Cortese, Francisco Xavier Castellanos
BACKGROUND: Diffusion tensor imaging studies have shown atypical fractional anisotropy (FA) in individuals with attention-deficit/hyperactivity disorder (ADHD), albeit with conflicting results. We performed meta-analyses of whole-brain voxel-based analyses (WBVBA) and tract-based spatial statistics (TBSS) studies in ADHD, along with a qualitative review of TBSS studies addressing the issue of head motion, which may bias results. METHODS: We conducted a systematic literature search (last search on April 1st, 2016) to identify studies comparing FA values between individuals with ADHD and typically developing (TD) participants...
July 3, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28670621/changes-in-dti-diffusivity-and-fmri-connectivity-cluster-coefficients-for-students-with-and-without-specific-learning-disabilities-in-written-language-brain-s-response-to-writing-instruction
#17
Todd L Richards, Virginia W Berninger, Kevin J Yagle, Robert D Abbott, Daniel J Peterson
Before and after computerized writing instruction, participants completed assessment with normed measures and DTI and fMRI connectivity scanning. Evidence-based differential diagnosis was used at time 1 to assign them to diagnostic groups: typical oral and written language (n=6), dysgraphia (impaired handwriting, n=10), dyslexia (impaired word spelling and reading, n=20), and OWL LD (impaired syntax construction, n=6). The instruction was aimed at subword letter writing, word spelling, and syntax composing...
April 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28666248/white-matter-abnormalities-in-treatment-naive-adolescents-at-the-earliest-stages-of-anorexia-nervosa-a-diffusion-tensor-imaging-study
#18
Santino Gaudio, Carlo Cosimo Quattrocchi, Claudia Piervincenzi, Bruno Beomonte Zobel, Francesca Romana Montecchi, Antonios Dakanalis, Giuseppe Riva, Filippo Carducci
Few studies have examined white matter (WM) integrity in long-lasting Anorexia Nervosa (AN) patients using Diffusion Tensor Imaging (DTI). In this paper, we investigated WM integrity at the earliest stages of AN (i.e. less than 6 months duration). Fourteen treatment-naive female adolescents with AN restrictive type (AN-r) in its earliest stages and 15 age-matched healthy females received brain MRI. Fractional Anisotropy (FA), Axial Diffusivity (AD), Radial diffusivity (RD), and Mean Diffusivity (MD) maps were computed from DTI data using Tract-Based Spatial Statistics analysis...
June 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28665045/extraction-of-dynamic-functional-connectivity-from-brain-grey-matter-and-white-matter-for-mci-classification
#19
Xiaobo Chen, Han Zhang, Lichi Zhang, Celina Shen, Seong-Whan Lee, Dinggang Shen
Brain functional connectivity (FC) extracted from resting-state fMRI (RS-fMRI) has become a popular approach for diagnosing various neurodegenerative diseases, including Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). Current studies mainly construct the FC networks between grey matter (GM) regions of the brain based on temporal co-variations of the blood oxygenation level-dependent (BOLD) signals, which reflects the synchronized neural activities. However, it was rarely investigated whether the FC detected within the white matter (WM) could provide useful information for diagnosis...
June 30, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28663738/cerebral-microstructural-alterations-after-radiation-therapy-in-high-grade-glioma-a-diffusion-tensor-imaging-based-study
#20
Rebecca Kassubek, Martin Gorges, Mike-Andrew Westhoff, Albert C Ludolph, Jan Kassubek, Hans-Peter Müller
OBJECTIVE: To investigate radiation therapy-induced microstructural damage of white matter in patients with high-grade glioma by diffusion tensor imaging (DTI). METHODS: DTI was performed in 18 patients with high-grade glioma (WHO grades III and IV) and 13 healthy controls. DTI images were cross-sectionally aligned for the calculation of baseline fractional anisotropy (FA). Interhemispheric FA values in patients with high-grade glioma before or without brain radiation therapy were compared with the interhemispheric FA values in patients after radiation therapy and in healthy controls...
2017: Frontiers in Neurology
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